WO2022132087A1 - Solution and skin care product enabling to reduce water loss from the skin surface and increase humidity of the skin - Google Patents

Solution and skin care product enabling to reduce water loss from the skin surface and increase humidity of the skin Download PDF

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Publication number
WO2022132087A1
WO2022132087A1 PCT/TR2021/051253 TR2021051253W WO2022132087A1 WO 2022132087 A1 WO2022132087 A1 WO 2022132087A1 TR 2021051253 W TR2021051253 W TR 2021051253W WO 2022132087 A1 WO2022132087 A1 WO 2022132087A1
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WIPO (PCT)
Prior art keywords
vitamin
solution
weight
skin
acid
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PCT/TR2021/051253
Other languages
French (fr)
Inventor
Gulcin Almina FIDANLIK
Urun Kandemirer
Original Assignee
Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi
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Publication of WO2022132087A1 publication Critical patent/WO2022132087A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E

Definitions

  • the subject of the invention relates to a solution for reducing the transepidermal water loss from the skin surface and for increasing the humidity of the skin by preserving the natural balance of the skin, and to a skin care product in which said solution is employed.
  • the skin surface is the part of the body that is in continuous contact with the external environment and in interaction with numerous environmental factors and is thus exposed to numerous microbial agents in the environments contacted.
  • the skin is the part of the body that protects the internal organs from the external mechanical, chemical and biological effects by separating the same from the external environment, assists with the regulation of the body temperature and water balance and is capable of self-repair by performing the production of collagen and protein. Therefore, it is of importance to cleanse the skin without disrupting the skin barrier and the moisture balance.
  • the need to clean our hands or face is today commonly satisfied still by the use of wet wipes.
  • the wet wipes are required to cleanse the skin without damaging the skin surface where they contact and by protecting the natural skin barrier and to provide the proper conditions of hygiene. Because of their practical use, the wet wipes are today frequently used even in the restaurants, schools and hospitals, on the surfaces as well as on various body parts such as hands, face, etc. for the purposes of cleaning and hygiene. Because of their practical use, the mothers also make use of the wet wipes for cleansing the skin of their babies.
  • the wet wipes being used are expected to cleanse the skin surface and achieve the hygienic conditions while at the same time preserving the skin barrier and the moisture balance of the skin.
  • Stratum corneum is the outermost layer of epidermis of the skin, with the skin having the characteristics of a wall that separates the body from the external environment and protects the body from the external mechanical, chemical and biological effects and regulating the water balance and temperature of the body.
  • the primary duty of the stratum corneum layer being in a state of permanent contact with the external environment is to enable the skin to preserve its natural flexible and elastic structure by maintaining the water content of the skin above 10%.
  • the water loss is prevented by means of the natural moisturizing factors such as free amino acids, carboxylic acid, sugars, urea, ammonia, uric acid, keratin, calcium, magnesium, phosphate, citrate and chloride that constitute 20-30% of the total dry weight of the stratum corneum, draw from the atmosphere the water in a quantity that is 3-4 times their weight and are present in a state dissolved in said water. Due to the presence of high alcohol content or cleansing agents in the products used especially for the hand hygiene, the frequent use of such products causes a decrease in the natural moisturizing factors in the stratum corneum, and thus a decrease in the water content of the same, the loss of function of the stratum corneum and the disruption of the natural structure of the skin.
  • the natural moisturizing factors such as free amino acids, carboxylic acid, sugars, urea, ammonia, uric acid, keratin, calcium, magnesium, phosphate, citrate and chloride that constitute 20-30% of the total dry weight of the strat
  • the disruption of the skin structure also leads to a decrease in the production of the lipids with moisturizing action and it becomes impossible to provide the skin's need for moisture from the lipids either.
  • the loss of water causes the skin to dry, the itching, exfoliation and cracks develop on the dry skin, the cracks provide a favorable environment as a host for the pathogenic microorganisms that are intended to be removed and the microorganisms accumulate in these cracks having the characteristics of an open wound and thus cause infection in the course of time.
  • the conventional care products with moisturizing action comprise the compounds having moisturizing action such as polyhydric alcohols, sodium lactate, urea, propylene glycol, sorbitol, carboxylic acid, hyaluronic acid, inorganic salts, vitamins and proteins.
  • These compounds enable the stratum corneum to be moisturized by drawing water from the external environment when the humidity in the atmosphere is greater than the humidity of the skin and by drawing water from the epidermis and dermis layers of the skin when the humidity in the atmosphere is lower than the humidity of the skin.
  • additional products with moisturizing action after ensuring the skin hygiene, which brings about the necessity for the users to apply two separate products and further involves the discomfort on the side of the users resulting from contacting the different agents with the skin surface successively.
  • Table 1 Ingredients of the exemplary solutions prepared to demonstrate the effect of the solution according to the invention
  • Table 2 Effect of the applied samples on the humidity increase and transepidermal water loss as compared to the values prior to the application of the samples on the users
  • An object of the invention is to develop a solution enabling to reduce the transepidermal water loss from the skin surface and increase the humidity of the skin.
  • Another object of the invention is to develop a skin care product, which is to be used for cleansing the skin surface and which is to enable an increase in the humidity of the skin by preserving the skin barrier.
  • Another object of the invention is to develop a skin care product, which is to be used for cleansing the skin surface, wherein the transepidermal water loss from the skin surface is reduced by way of preservation of the skin barrier.
  • Another object of the invention is to develop a wet wipe as the skin care product.
  • the subject of the invention relates to a solution for reducing the transepidermal water loss from the skin surface and for increasing the humidity of the skin by preserving the natural balance of the skin, and to a skin care product in which said solution is employed.
  • the products used for ensuring the cleanliness of the skin cause the disruption of the moisture balance of the skin and development of dry skin, due to their high alcohol or cleansing agent contents.
  • the dryness problem developing in the skin in addition to adversely affecting the skin health and thus leading to many skin diseases, also causes the ageing of the skin. Accordingly, it is rather important to ensure that the products used for cleansing the skin and providing the hygiene at the same time preserve the moisture balance of the skin.
  • the wet wipes are among the leading products used for cleansing the skin.
  • the wet wipes are obtained by impregnating a carrier fabric (nonwoven fabric) with a liquid solution, which is formulated differently for different applications.
  • ingredients of the wet wipe solutions used for cleaning the babies and for performing the cleansing intended for personal care mostly comprise the water, a preservative and a cleansing agent
  • the use of pH regulating agents and moisturizing agents is also possible. It is further possible to incorporate in the solution the additional agents such as the soothing agents, minerals, antioxidants, additives of vegetable nature and perfumes.
  • the use of the topically-applied vitamin-containing cosmetic products in the skin care is becoming gradually common. Vitamin B, vitamin E and vitamin C are among the vitamins the use of which is frequently encountered in the cosmetic products.
  • Vitamin E is a fat-soluble vitamin. It provides benefits for the health of eyes and heart as it reduces the lipid peroxide. When applied topically, it increases the moisture capacity of the skin, triggers the cell development and is a strong antioxidant. It may be said to reduce the tumor development risk and the wrinkle formation in the skin and provide anti-aging action. It further enables the protection of the vitamins such as vitamin A and vitamin C.
  • Vitamin B has various forms. Although calcium pantothenate is sometimes used in the cosmetic products, the use of provitamin (D-panthenol), which features ready penetration, is usually preferred. In the skin, D-panthenol is oxidized and turns into pantothenic acid. It has benefits such as increasing the skin hydration, therapeutic effects in the inflammatory process, cell development and epithelization after the skin lesions.
  • provitamin D-panthenol
  • Niacinamide a form of niacin (vitamin B3), was observed to exhibit anti-inflammatory action when applied to the skin. For this reason, it is used against acnes. Further, there are studies suggesting its ability to reduce the transepidermal water loss and mitigate the ageing of the skin. The topical niacinamide administration was observed to provide benefits against the diseases involving the skin eruption and rosacea. Further, as is the case with the other topically applied vitamins, the vitamin B3 is effective in preventing the skin cancer associated with the UV rays.
  • vitamin C Ascorbate (vitamin C) is an important vitamin that is water-soluble. Its antioxidant character and its use as a cofactor in the hydroxylation reaction required for the collagen production make vitamin C important. Since vitamin C is not produced in the body, it must be taken externally. The reasons for the use of vitamin C in the cosmetic products may be mentioned as its abilities to suppress the free radicals originating from the UV (antioxidant action), regenerate vitamin E, which is another important antioxidant, provide the slowing down action on the ageing process by triggering the collagen production and prevent hyperpigmentation.
  • the vitamin C has three forms preferred for use in the cosmetic products; namely ascorbyl palmitate, magnesium ascorbyl phosphate and L-ascorbic acid. All said forms, in addition to having the antioxidant property, serve other functions such as anti-inflammatory action and protective action against lipid peroxide.
  • L-ascorbic acid is the most bioactive form of vitamin C. It is quite beneficial for the skin. It is water-soluble and needs to be used at low pH values so that it can be stable in the formulation. It increases type 1 and type 3 procollagen MRNA levels in the human skin fibroblasts and stimulates the collagen synthesis in the collagen matrix. It exhibits antioxidant action.
  • the solution developed within the scope of the invention contains vitamin B, vitamin C and vitamin E in the form of a complex in order to ensure the greatest extent of benefit from the known actions of the vitamins on the skin. In this way, the action on the skin is enhanced by achieving a synergistic action among different vitamins while optimizing the amount of use. It has been further made possible that no separate antioxidant for the vitamins is added to the formulation developed within the scope of the invention.
  • vitamins are used in the cosmetic products according to the state of the art. However, the vitamins are not used in their effective ratios and in a way generating a synergistic action together.
  • the solution developed within the scope of the invention comprises at least one vitamin complex, preferably a vitamin complex including vitamin C, vitamin B and vitamin E.
  • the invention further encompasses a skin care product in which the developed vitamin complex-including solution is applied.
  • Said skin care product is preferably a wet wipe.
  • the solutions containing said vitamins separately and the solution comprising the vitamin complex according to the invention were compared and the effect of the developed solution on the increase in the humidity and on the decrease in the transepidermal water loss was demonstrated.
  • the solution according to the invention additionally comprises at least one pH regulating agent.
  • the use of at least one acid and the conjugate base of the acid was preferred as the pH regulating agent.
  • the solution developed within the scope of the invention comprises the pH regulating agent preferably at a ratio of 2-4% by weight.
  • An alternative embodiment of the invention comprises as the pH regulating agent at least one acid at a ratio of 1-2% by weight and the conjugate base of the acid at a ratio of 1-2% by weight.
  • the solution according to the invention additionally comprises at least one preservative agent.
  • the solution comprises said preservative agent preferably at a ratio of 1-5.5% by weight.
  • components selected from but not limited to benzoic acid and/or pentylene glycol as the preservative agent.
  • An alternative embodiment of the invention comprises 0.1-1% by weight vitamin E, 0.1-1% by weight vitamin B and 0.1-0.5% by weight vitamin C.
  • tocopheryl acetate is used as vitamin E
  • panthenol is used as vitamin B
  • ascorbic acid is used as vitamin C.
  • Said embodiment additionally comprises 1-5.5% by weight at least one preservative agent and 2-4% by weight at least one pH regulating agent.
  • the use of benzoic acid at a ratio of 0.1-0.5% by weight and/or pentylene glycol at a ratio of 1-5% by weight was preferred as the preservative agent.
  • the pH regulating agent the use of citric acid at a ratio of 1-2% by weight and sodium citrate at a ratio of 1-2% by weight was preferred.
  • Another alternative embodiment of the invention comprises 0.1-0.5% by weight vitamin E, 0.1-0.5% by weight vitamin B and 0.1-0.25% by weight vitamin C.
  • tocopheryl acetate is used as vitamin E
  • panthenol is used as vitamin B
  • ascorbic acid is used as vitamin C.
  • Said embodiment additionally comprises 1-5.5% by weight at least one preservative agent and 2-4% by weight at least one pH regulating agent.
  • the use of benzoic acid at a ratio of 0.1-0.5% by weight and/or pentylene glycol at a ratio of 1-5% by weight was preferred as the preservative agent.
  • the pH regulating agent the use of citric acid at a ratio of 1-2% by weight and sodium citrate at a ratio of 1-2% by weight was preferred.
  • the solution developed within the scope of the invention additionally comprises water. It is possible to add water in a quantity sufficient to complement the solution to 100% by weight depending on the quantities of the agents employed.
  • the skin care product comprising the vitamin complex was obtained by way of application of the solution developed within the scope of the invention to a nonwoven fabric.
  • Said skin care product is preferably a wet wipe.
  • the solutions containing said vitamins separately and the solution comprising the vitamin complex according to the invention were compared and the effect of the developed solution on the increase in the humidity and on the decrease in the transepidermal water loss was demonstrated.
  • the solution comprising the vitamin complex according to the invention as well as the solutions comprising, alone or in binary combinations, the vitamins mentioned in the following table were applied on the arms of the participants, and the values of humidity and transepidermal water loss were examined in the users subjected to application and the users without the application of the solution.
  • the samples obtained from the application regions of the participants by means of the probes Corneometer CM 825 and Tewameter TM 300 were examined. By means of these probes, the humidity in the skin and the TEWL (transepidermal water loss) in the skin were measured. These measurements were compared to the results obtained prior to application. The measurement results are shown in Table 2.
  • the solutions developed within the scope of the invention were numbered as Examples 6 and 7, and the other solutions intended for comparison to demonstrate the effects of these solutions were numbered Examples 1-5, respectively.
  • the solutions of Examples 1-5 comprise the employed vitamins either alone or in binary combinations.
  • Table 1 Ingredients of the exemplary solutions prepared to demonstrate the effect of the solution according to the invention
  • Table 2 Effect of the applied samples on the humidity increase and transepidermal water loss as compared to the values prior to the application of the samples on the users
  • Example 6 The solutions according to the invention were numbered as Examples 6 and 7 for the comparative study.
  • vitamin E, vitamin B and vitamin C were used in combination in Example 6 as disclosed within the scope of the invention and the effect of the combined vitamins on the skin humidity was observed to almost double as compared to the previous Examples 1-5.
  • Example 7 is another alternative solution according to the invention and also comprises vitamin E, vitamin B and vitamin C in combination. In this alternative embodiment, the quantities of the vitamins used were reduced as compared to those in Example 6 and the vitamins were observed to exert almost the same effect when compared to Example 6.

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Abstract

The subject of the invention relates to a solution for reducing the transepidermal water loss from the skin surface and for increasing the humidity of the skin by preserving the natural balance of the skin, and to a skin care product in which said solution is employed. The solution developed within the scope of the invention comprises different vitamin ingredients in the form of a complex. The solution comprises a vitamin complex preferably containing vitamin C, vitamin B and vitamin E.

Description

SOLUTION AND SKIN CARE PRODUCT ENABLING TO REDUCE WATER LOSS FROM THE SKIN SURFACE AND INCREASE HUMIDITY OF THE SKIN
Subject of the Invention
The subject of the invention relates to a solution for reducing the transepidermal water loss from the skin surface and for increasing the humidity of the skin by preserving the natural balance of the skin, and to a skin care product in which said solution is employed.
State of the Art
The skin surface is the part of the body that is in continuous contact with the external environment and in interaction with numerous environmental factors and is thus exposed to numerous microbial agents in the environments contacted. Besides, the skin is the part of the body that protects the internal organs from the external mechanical, chemical and biological effects by separating the same from the external environment, assists with the regulation of the body temperature and water balance and is capable of self-repair by performing the production of collagen and protein. Therefore, it is of importance to cleanse the skin without disrupting the skin barrier and the moisture balance.
In the ambiences such as travel ambience where to make use of water is not immediately possible or in the ambiences such as public transport where the hygienic conditions are not appropriate, the need to clean our hands or face is today commonly satisfied still by the use of wet wipes. The wet wipes, the use of which has become quite widespread, are required to cleanse the skin without damaging the skin surface where they contact and by protecting the natural skin barrier and to provide the proper conditions of hygiene. Because of their practical use, the wet wipes are today frequently used even in the restaurants, schools and hospitals, on the surfaces as well as on various body parts such as hands, face, etc. for the purposes of cleaning and hygiene. Because of their practical use, the mothers also make use of the wet wipes for cleansing the skin of their babies.
The wet wipes being used are expected to cleanse the skin surface and achieve the hygienic conditions while at the same time preserving the skin barrier and the moisture balance of the skin.
Stratum corneum is the outermost layer of epidermis of the skin, with the skin having the characteristics of a wall that separates the body from the external environment and protects the body from the external mechanical, chemical and biological effects and regulating the water balance and temperature of the body. The primary duty of the stratum corneum layer being in a state of permanent contact with the external environment is to enable the skin to preserve its natural flexible and elastic structure by maintaining the water content of the skin above 10%. The water loss is prevented by means of the natural moisturizing factors such as free amino acids, carboxylic acid, sugars, urea, ammonia, uric acid, keratin, calcium, magnesium, phosphate, citrate and chloride that constitute 20-30% of the total dry weight of the stratum corneum, draw from the atmosphere the water in a quantity that is 3-4 times their weight and are present in a state dissolved in said water. Due to the presence of high alcohol content or cleansing agents in the products used especially for the hand hygiene, the frequent use of such products causes a decrease in the natural moisturizing factors in the stratum corneum, and thus a decrease in the water content of the same, the loss of function of the stratum corneum and the disruption of the natural structure of the skin. The disruption of the skin structure also leads to a decrease in the production of the lipids with moisturizing action and it becomes impossible to provide the skin's need for moisture from the lipids either. The loss of water causes the skin to dry, the itching, exfoliation and cracks develop on the dry skin, the cracks provide a favorable environment as a host for the pathogenic microorganisms that are intended to be removed and the microorganisms accumulate in these cracks having the characteristics of an open wound and thus cause infection in the course of time.
Consequently, it is necessary to frequently moisturize the skin by means of the care products with moisturizing action that are to be applied externally following the use of the products intended for cleansing the skin. The conventional care products with moisturizing action comprise the compounds having moisturizing action such as polyhydric alcohols, sodium lactate, urea, propylene glycol, sorbitol, carboxylic acid, hyaluronic acid, inorganic salts, vitamins and proteins. These compounds enable the stratum corneum to be moisturized by drawing water from the external environment when the humidity in the atmosphere is greater than the humidity of the skin and by drawing water from the epidermis and dermis layers of the skin when the humidity in the atmosphere is lower than the humidity of the skin. In this case, it becomes necessary to use additional products with moisturizing action after ensuring the skin hygiene, which brings about the necessity for the users to apply two separate products and further involves the discomfort on the side of the users resulting from contacting the different agents with the skin surface successively.
In an effort to provide a solution to said problem, it is aimed within the scope of the invention to reduce the transepidermal water loss from the skin surface and increase the humidity of the skin by way of enriching the contents of a product, such as a wet wipe, used for the skin cleansing.
In order to satisfy the above-mentioned need and resolve the above-mentioned problems of the state of the art, a solution enabling to reduce the transepidermal water loss from the skin surface and increase the humidity of the skin and a skin care product in which said solution is employed have been developed within the scope of the invention. Description of the Tables
Table 1: Ingredients of the exemplary solutions prepared to demonstrate the effect of the solution according to the invention
Table 2: Effect of the applied samples on the humidity increase and transepidermal water loss as compared to the values prior to the application of the samples on the users
Object of the Invention
An object of the invention is to develop a solution enabling to reduce the transepidermal water loss from the skin surface and increase the humidity of the skin.
Another object of the invention is to develop a skin care product, which is to be used for cleansing the skin surface and which is to enable an increase in the humidity of the skin by preserving the skin barrier.
Another object of the invention is to develop a skin care product, which is to be used for cleansing the skin surface, wherein the transepidermal water loss from the skin surface is reduced by way of preservation of the skin barrier.
Another object of the invention is to develop a wet wipe as the skin care product.
Description of the Invention
The subject of the invention relates to a solution for reducing the transepidermal water loss from the skin surface and for increasing the humidity of the skin by preserving the natural balance of the skin, and to a skin care product in which said solution is employed.
The products used for ensuring the cleanliness of the skin cause the disruption of the moisture balance of the skin and development of dry skin, due to their high alcohol or cleansing agent contents. The dryness problem developing in the skin, in addition to adversely affecting the skin health and thus leading to many skin diseases, also causes the ageing of the skin. Accordingly, it is rather important to ensure that the products used for cleansing the skin and providing the hygiene at the same time preserve the moisture balance of the skin.
Owing to their practical use, the wet wipes are among the leading products used for cleansing the skin. The wet wipes are obtained by impregnating a carrier fabric (nonwoven fabric) with a liquid solution, which is formulated differently for different applications.
While the ingredients of the wet wipe solutions used for cleaning the babies and for performing the cleansing intended for personal care mostly comprise the water, a preservative and a cleansing agent, the use of pH regulating agents and moisturizing agents is also possible. It is further possible to incorporate in the solution the additional agents such as the soothing agents, minerals, antioxidants, additives of vegetable nature and perfumes. The use of the topically-applied vitamin-containing cosmetic products in the skin care is becoming gradually common. Vitamin B, vitamin E and vitamin C are among the vitamins the use of which is frequently encountered in the cosmetic products.
Vitamin E is a fat-soluble vitamin. It provides benefits for the health of eyes and heart as it reduces the lipid peroxide. When applied topically, it increases the moisture capacity of the skin, triggers the cell development and is a strong antioxidant. It may be said to reduce the tumor development risk and the wrinkle formation in the skin and provide anti-aging action. It further enables the protection of the vitamins such as vitamin A and vitamin C.
Vitamin B has various forms. Although calcium pantothenate is sometimes used in the cosmetic products, the use of provitamin (D-panthenol), which features ready penetration, is usually preferred. In the skin, D-panthenol is oxidized and turns into pantothenic acid. It has benefits such as increasing the skin hydration, therapeutic effects in the inflammatory process, cell development and epithelization after the skin lesions.
Niacinamide, a form of niacin (vitamin B3), was observed to exhibit anti-inflammatory action when applied to the skin. For this reason, it is used against acnes. Further, there are studies suggesting its ability to reduce the transepidermal water loss and mitigate the ageing of the skin. The topical niacinamide administration was observed to provide benefits against the diseases involving the skin eruption and rosacea. Further, as is the case with the other topically applied vitamins, the vitamin B3 is effective in preventing the skin cancer associated with the UV rays.
Ascorbate (vitamin C) is an important vitamin that is water-soluble. Its antioxidant character and its use as a cofactor in the hydroxylation reaction required for the collagen production make vitamin C important. Since vitamin C is not produced in the body, it must be taken externally. The reasons for the use of vitamin C in the cosmetic products may be mentioned as its abilities to suppress the free radicals originating from the UV (antioxidant action), regenerate vitamin E, which is another important antioxidant, provide the slowing down action on the ageing process by triggering the collagen production and prevent hyperpigmentation.
The vitamin C has three forms preferred for use in the cosmetic products; namely ascorbyl palmitate, magnesium ascorbyl phosphate and L-ascorbic acid. All said forms, in addition to having the antioxidant property, serve other functions such as anti-inflammatory action and protective action against lipid peroxide.
L-ascorbic acid is the most bioactive form of vitamin C. It is quite beneficial for the skin. It is water-soluble and needs to be used at low pH values so that it can be stable in the formulation. It increases type 1 and type 3 procollagen MRNA levels in the human skin fibroblasts and stimulates the collagen synthesis in the collagen matrix. It exhibits antioxidant action. The solution developed within the scope of the invention contains vitamin B, vitamin C and vitamin E in the form of a complex in order to ensure the greatest extent of benefit from the known actions of the vitamins on the skin. In this way, the action on the skin is enhanced by achieving a synergistic action among different vitamins while optimizing the amount of use. It has been further made possible that no separate antioxidant for the vitamins is added to the formulation developed within the scope of the invention.
Various vitamins are used in the cosmetic products according to the state of the art. However, the vitamins are not used in their effective ratios and in a way generating a synergistic action together.
It was determined that, owing to the synergistic action provided by means of the vitamins that are to be used in combination as a vitamin complex in the solution according to the invention, the vitamins exhibit greater activity on the skin even when used in small quantities.
The solution developed within the scope of the invention comprises at least one vitamin complex, preferably a vitamin complex including vitamin C, vitamin B and vitamin E.
The invention further encompasses a skin care product in which the developed vitamin complex-including solution is applied. Said skin care product is preferably a wet wipe.
Further, within the scope of the invention, the solutions containing said vitamins separately and the solution comprising the vitamin complex according to the invention were compared and the effect of the developed solution on the increase in the humidity and on the decrease in the transepidermal water loss was demonstrated.
In an alternative embodiment, the solution according to the invention additionally comprises at least one pH regulating agent. The use of at least one acid and the conjugate base of the acid was preferred as the pH regulating agent.
The solution developed within the scope of the invention comprises the pH regulating agent preferably at a ratio of 2-4% by weight.
An alternative embodiment of the invention comprises as the pH regulating agent at least one acid at a ratio of 1-2% by weight and the conjugate base of the acid at a ratio of 1-2% by weight.
The use of at least one conjugated acid-base pair selected from but not limited to citric acid and sodium citrate conjugated acid-base pair, lactic acid-sodium lactate conjugated acidbase pair and acetic acid-sodium acetate conjugated acid-base pair was preferred as said pH regulating agent. In an alternative embodiment, the solution according to the invention additionally comprises at least one preservative agent. The solution comprises said preservative agent preferably at a ratio of 1-5.5% by weight.
Within the scope of the invention, it is possible to use components selected from but not limited to benzoic acid and/or pentylene glycol as the preservative agent.
An alternative embodiment of the invention comprises 0.1-1% by weight vitamin E, 0.1-1% by weight vitamin B and 0.1-0.5% by weight vitamin C. In said embodiment, tocopheryl acetate is used as vitamin E, panthenol is used as vitamin B and ascorbic acid is used as vitamin C. Said embodiment additionally comprises 1-5.5% by weight at least one preservative agent and 2-4% by weight at least one pH regulating agent. In said embodiment, the use of benzoic acid at a ratio of 0.1-0.5% by weight and/or pentylene glycol at a ratio of 1-5% by weight was preferred as the preservative agent. As the pH regulating agent, the use of citric acid at a ratio of 1-2% by weight and sodium citrate at a ratio of 1-2% by weight was preferred.
Another alternative embodiment of the invention comprises 0.1-0.5% by weight vitamin E, 0.1-0.5% by weight vitamin B and 0.1-0.25% by weight vitamin C. In said embodiment, tocopheryl acetate is used as vitamin E, panthenol is used as vitamin B and ascorbic acid is used as vitamin C. Said embodiment additionally comprises 1-5.5% by weight at least one preservative agent and 2-4% by weight at least one pH regulating agent. In said embodiment, the use of benzoic acid at a ratio of 0.1-0.5% by weight and/or pentylene glycol at a ratio of 1-5% by weight was preferred as the preservative agent. As the pH regulating agent, the use of citric acid at a ratio of 1-2% by weight and sodium citrate at a ratio of 1-2% by weight was preferred.
The solution developed within the scope of the invention additionally comprises water. It is possible to add water in a quantity sufficient to complement the solution to 100% by weight depending on the quantities of the agents employed.
The skin care product comprising the vitamin complex was obtained by way of application of the solution developed within the scope of the invention to a nonwoven fabric. Said skin care product is preferably a wet wipe.
Further, within the scope of the invention, the solutions containing said vitamins separately and the solution comprising the vitamin complex according to the invention were compared and the effect of the developed solution on the increase in the humidity and on the decrease in the transepidermal water loss was demonstrated. In the study conducted in this regard, the solution comprising the vitamin complex according to the invention as well as the solutions comprising, alone or in binary combinations, the vitamins mentioned in the following table were applied on the arms of the participants, and the values of humidity and transepidermal water loss were examined in the users subjected to application and the users without the application of the solution. For the analysis, the samples obtained from the application regions of the participants by means of the probes Corneometer CM 825 and Tewameter TM 300 were examined. By means of these probes, the humidity in the skin and the TEWL (transepidermal water loss) in the skin were measured. These measurements were compared to the results obtained prior to application. The measurement results are shown in Table 2.
The solutions developed within the scope of the invention were numbered as Examples 6 and 7, and the other solutions intended for comparison to demonstrate the effects of these solutions were numbered Examples 1-5, respectively. The solutions of Examples 1-5 comprise the employed vitamins either alone or in binary combinations. Table 1: Ingredients of the exemplary solutions prepared to demonstrate the effect of the solution according to the invention
Figure imgf000008_0001
Table 2: Effect of the applied samples on the humidity increase and transepidermal water loss as compared to the values prior to the application of the samples on the users
Figure imgf000009_0001
In the study conducted, vitamin E, vitamin B and vitamin C were used alone in Examples 1, 2 and 3, and in binary combinations in Examples 4 and 5. As can be seen from Table 2, the binary combinations of the vitamins were observed to be more effective in increasing the skin humidity and preventing the transepidermal water loss as compared to the singular uses of the vitamins.
The solutions according to the invention were numbered as Examples 6 and 7 for the comparative study. As can be seen from Table 2, vitamin E, vitamin B and vitamin C were used in combination in Example 6 as disclosed within the scope of the invention and the effect of the combined vitamins on the skin humidity was observed to almost double as compared to the previous Examples 1-5. Example 7 is another alternative solution according to the invention and also comprises vitamin E, vitamin B and vitamin C in combination. In this alternative embodiment, the quantities of the vitamins used were reduced as compared to those in Example 6 and the vitamins were observed to exert almost the same effect when compared to Example 6.
Although different vitamins in combination were used in lower quantities than those in case of said vitamins being each used alone, they were observed to be much more effective in terms of increasing the humidity of the skin and reducing the water loss from the skin surface, owing to the synergistic action resulting from the combined use of said vitamins.

Claims

1. A solution developed for enabling an increase in the humidity of the skin and a reduction in the transepidermal water loss characterized in that the solution comprises a vitamin complex containing vitamin C, vitamin E and vitamin B in combination.
2. A solution according to Claim 1 characterized in that the solution comprises tocopheryl acetate as vitamin E, ascorbic acid as vitamin C, and panthenol as vitamin B.
3. A solution according to Claim 2 characterized in that the solution comprises 0.1-1% by weight vitamin E, 0.1-1% by weight vitamin B, and 0.1-0.5% by weight vitamin C.
4. A solution according to Claim 2 characterized in that the solution comprises 0.1-0.5% by weight vitamin E, 0.1-0.5% by weight vitamin B, and 0.1-0.25% by weight vitamin C.
5. A solution according to any one of Claims 1-4 characterized in that the solution additionally comprises at least one pH regulating agent.
6. A solution according to Claim 5 characterized in that the solution comprises said pH regulating agent at a ratio of 2-4% by weight.
7. A solution according to Claim 5 characterized in that said pH regulating agent is at least one acid and the conjugate base of the said acid.
8. A solution according to Claim 7 characterized in that the solution comprises citric acid and its conjugate base sodium citrate as said pH regulating agent.
9. A solution according to Claim 7 characterized in that the solution comprises at least one conjugated acid-base pair selected from lactic acid-sodium lactate or acetic acid-sodium acetate as said pH regulating agent.
10. A solution according to Claim 8 characterized in that the solution comprises citric acid at a ratio of 1-2% by weight and sodium citrate at a ratio of 1-2% by weight as said pH regulating agent.
11. A solution according to any one of the preceding claims characterized in that the solution additionally comprises at least one preservative agent.
12. A solution according to Claim 11 characterized in that the solution comprises said preservative agent at a ratio of 1-5.5% by weight.
13. A solution according to Claim 11 characterized in that the solution comprises benzoic acid at a ratio of 0.1-0.5% by weight and/or pentylene glycol at a ratio of 1-5% by weight as said preservative agent.
14. A solution according to any one of the preceding claims characterized in that the solution additionally comprises water.
9
15. A solution according to Claim 1 characterized in that the solution comprises
• 0.1-1% by weight vitamin E, 0.1-1% by weight vitamin B and 0.1-0.5% by weight vitamin C, or 0.1-0.5% by weight vitamin E, 0.1-0.5% by weight vitamin B and 0.1- 0.25% by weight vitamin C, and additionally, • a pH regulating agent consisting of 1-2% by weight acid and 1-2% by weight the conjugate base of the acid, and additionally,
• a preservative agent consisting of benzoic acid at a ratio of 0.1-0.5% by weight and/or pentylene glycol at a ratio of 1-5% by weight.
16. A solution according to Claim 15 characterized in that said pH regulating agent comprises citric acid and sodium citrate, conjugate base of the acid.
17. A skin care product characterized in that the skin care product comprises a solution according to any one of the preceding claims.
18. A skin care product according to Claim 17 characterized in that the skin care product is wet wipe.
PCT/TR2021/051253 2020-12-18 2021-11-22 Solution and skin care product enabling to reduce water loss from the skin surface and increase humidity of the skin WO2022132087A1 (en)

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TR2020/20925A TR202020925A1 (en) 2020-12-18 2020-12-18 A SOLUTION AND A SKIN CARE PRODUCT THAT REDUCES WATER LOSS FROM THE SKIN SURFACE AND INCREASE THE MOISTURE OF THE SKIN
TR2020/20925 2020-12-18

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036946A (en) * 1997-12-24 2000-03-14 Shaklee Corporation Methods for protecting skin from damaging effects of ultraviolet light
US20060222689A1 (en) * 2003-05-16 2006-10-05 Lotus Pharmaceutical Co., Ltd. Skin care compositions and methods
EP1752132A2 (en) * 2005-08-08 2007-02-14 Lotus Pharmaceutical Co., Ltd. Skin cosmetic compositions
CN103356431A (en) * 2013-06-18 2013-10-23 沈阳创达技术交易市场有限公司 Moisturizing wet wipes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036946A (en) * 1997-12-24 2000-03-14 Shaklee Corporation Methods for protecting skin from damaging effects of ultraviolet light
US20060222689A1 (en) * 2003-05-16 2006-10-05 Lotus Pharmaceutical Co., Ltd. Skin care compositions and methods
EP1752132A2 (en) * 2005-08-08 2007-02-14 Lotus Pharmaceutical Co., Ltd. Skin cosmetic compositions
CN103356431A (en) * 2013-06-18 2013-10-23 沈阳创达技术交易市场有限公司 Moisturizing wet wipes

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