WO2022124753A1 - 전도성 피펫 장착용 어댑터, 시료튜브개폐장치 및 시료자동분석시스템 - Google Patents
전도성 피펫 장착용 어댑터, 시료튜브개폐장치 및 시료자동분석시스템 Download PDFInfo
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- WO2022124753A1 WO2022124753A1 PCT/KR2021/018433 KR2021018433W WO2022124753A1 WO 2022124753 A1 WO2022124753 A1 WO 2022124753A1 KR 2021018433 W KR2021018433 W KR 2021018433W WO 2022124753 A1 WO2022124753 A1 WO 2022124753A1
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- sample
- dispensing
- sample tube
- pipette
- unit
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Images
Classifications
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- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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- G01N2035/1069—Multiple transfer devices for transfer to or from containers having different spacing by adjusting the spacing between multiple probes of a single transferring head
Definitions
- the present invention relates to an adapter for mounting a conductive pipette, a sample tube opening/closing device, and an automatic sample analysis system, and more particularly, to an adapter for mounting a conductive pipette in which liquid sample dispensing, nucleic acid extraction, amplification and testing are performed integrally; It relates to a sample tube opening/closing device and an automatic sample analysis system.
- the gene amplification test method is an in vitro diagnostic testing (IVD testing) technology that amplifies a specific sequence of genes to determine the presence or absence of a gene. It is used in various fields such as inspection and GMO inspection.
- IVD testing in vitro diagnostic testing
- the target nucleic acid extracted in this way is mixed with a gene amplification solution to perform a gene amplification reaction, and then the DNA corresponding to the length of the DNA of the gene amplification product is checked or the fluorescence generated from the gene amplification product is checked to complete the gene amplification test.
- the gene amplification test is a method for amplifying a target nucleic acid, and various methods such as PCR, nested PCR, RT/PCR, and isothermal nucleic acid amplification have been developed.
- a preparation step of preparing a gene amplification reactant by mixing and a reaction step of proceeding the reaction may be performed.
- a dispensing device for dispensing a biological sample for dispensing a biological sample
- a purification extraction device for purifying and extracting a target material from the dispensed biological sample for purifying and extracting a target material from the dispensed biological sample
- an amplification testing device for amplifying and measuring the extracted target material for amplifying and measuring the extracted target material are separated, respectively, for dispensing, extraction and Amplification was performed respectively.
- An object of the present invention is to open and close the sample container in the equipment to eliminate the risk of infection of the user, prevent contamination, and open and close the cap of the sample tube to significantly reduce the time required for dispensing the biological sample in order to solve the above problems and to provide an adapter for mounting a conductive pipette, a sample tube opening/closing device, and an automatic sample analysis system in which dispensing, extraction, purification, and amplification tests are performed continuously and automatically.
- the present invention was created to achieve the object of the present invention as described above, and the present invention forms an internal space isolated from the outside, and a biological sample having a plurality of sample tubes 10 in which the biological sample is accommodated.
- a housing 110 including a door 120 for introducing and taking out the multi-well plate 20;
- a sample tube opening/closing device that is spaced apart from the multi-well plate (20) for biological samples and installed in the inner space, and includes a sample tube opening/closing unit that automatically opens and closes the sample tube (10).
- the sample tube opening and closing unit includes at least one lower gripper 200 for gripping the lower portion of the sample tube 10 and at least one upper gripper 300 for gripping the upper portion of the sample tube 10 . can do.
- the lower gripper 200 and the upper gripper 300 may be provided to correspond to each other in parallel by three each.
- the upper grippers 300 may be linearly movable in the X-direction, Y-direction, and Z-direction, respectively.
- the upper gripper 300 includes an upper gripping part 310 for gripping the upper portion of the sample tube 10; an upper gripper front-back driving unit 320 for moving the upper gripping unit 310 in a front-rear direction, which is a process processing direction; an upper gripper left and right driving unit 330 for moving the upper gripping unit 310 in a left and right direction with respect to a process processing direction; An upper gripper vertical drive unit 340 for moving the upper gripping unit 310 in the vertical direction may be included.
- the upper gripper 200 raises the sample by gripping the sealing member 12 sealing the sample tube 10 while the lower gripper 300 grips the lower portion of the sample tube 10 .
- the tube 10 may be opened.
- the upper gripper 200 and the lower gripper 300 may be rotated relative to each other to open the sample tube 10.
- the lower gripper 200 includes a lower gripping part 210 on which the sample tube 10 is seated and gripping the lower portion of the sample tube 10; It may include a lower gripper rotation driving unit 220 that rotates the lower gripping unit 210 around an imaginary center line passing through the center in the vertical direction of the sample tube 10 as an axis.
- the lower gripper 200 is disposed adjacent to the lower gripping unit 210 and recognizes the identification code 13 attached to the sample tube 10, thereby identifying the biological sample. (230) may be included.
- the housing 110 may include a UV lamp unit 130 provided on at least one of a lower surface of the inner space S and an upper portion of the door 120 .
- the housing 110 may include an ozone sensor 140 installed in the inner space S to detect ozone generated by the UV lamp unit 130 .
- the housing 110 may include a negative pressure forming unit 150 for performing exhaust in one direction from the inner space S to the outer space so that the inner space S maintains a negative pressure state.
- the negative pressure forming part 150 is provided on one side of the housing 110 and provided in front of the exhaust fan 151 for discharging the air of the internal space S, and is provided in front of the internal space (S). It may include an ozone filter 152 for filtering ozone present in S).
- the sample tube opening and closing device for automatically opening and closing the sealing member 12 of the sample tube 10 containing the biological sample; a dispensing device (1) for dispensing the biological sample from the sample tube (10); an automatic purification extraction device (2) for purifying and extracting a target material from the biological sample obtained from the dispensing device (1); Disclosed is an automatic sample analysis system including a nucleic acid amplification test device (3) for amplifying and measuring the target material obtained from the automatic purification and extraction device (2).
- the sample tube opening/closing device, the dispensing device 1, and the automatic stagnant extraction device 2 form a first internal space S1 isolated from the outside, and the nucleic acid amplification test device 3 is connected to the outside
- An isolated second inner space (S2) is formed, and the first inner space (S1) and the second inner space (S2) may communicate with each other.
- the target material is a target nucleic acid contained in the biological sample, and by amplifying the target nucleic acid, a quantitative or qualitative test may be performed.
- the target nucleic acid may be an aptamer nucleic acid or a nucleic acid of an antigen-nucleic acid conjugate selectively attached to the antigen or antibody among the antigens or antibodies included in the biological sample.
- Each of the nucleic acids, antigens and antibodies contained in the biological sample may be simultaneously quantitatively or qualitatively tested.
- the dispensing device (1), the automatic purification extraction device (2), and the nucleic acid amplification test device (3) may each have a door that is separated from each other.
- the dispensing device 1 moves between the sample tube opening and closing part, the pipette tip rack 80 and the multi-well plate 30 for dispensing, and sucks the biological sample in the sample tube 10 positioned at the sample tube opening and closing part.
- it may include a biological sample dispensing unit 400 for dispensing to the multi-well plate 30 for dispensing.
- the biological sample dispensing unit 400 includes a dispensing pipette 410 for sucking the biological sample in the sample tube 10 and dispensing the biological sample sucked into the dispensing multi-well plate 30; a dispensing pipette sensor unit 420 for controlling the amount of suction and dispensing for the biological sample of the dispensing pipette 410;
- the dispensing pipette 410 may include a dispensing pipette driver 430 for driving to move between the dispensing multi-well plate 30 from the sample tube 10 located in the first inner space. .
- the dispensing pipette sensor unit 420 may include a pressure sensor 421 for measuring a pressure level for detecting clogging of the dispensing pipette 410 at all times.
- the dispensing pipette sensor unit 420 is mounted on the dispensing pipette 410 and a level sensor 422 for detecting that the dispensing pipette tip 411 in which the biological sample is accommodated is in contact with the biological sample liquid level.
- a level sensor 422 for detecting that the dispensing pipette tip 411 in which the biological sample is accommodated is in contact with the biological sample liquid level.
- the nucleic acid amplification test apparatus 3 includes: a test housing forming a test space isolated from the outside; It may include a multi-well plate inserting unit into which a multi-well plate provided with a plurality of reaction tubes containing the target material extracted through the automatic purification extraction device (2) is inserted.
- the multi-well plate insertion part includes a support part for supporting the edge of the multi-well plate provided with a plurality of the reaction tubes, and the support part between the dispensing position of the automatic tablet extraction device 3 and the amplification position in the test housing. It may include a multi-well plate driver for driving.
- the inspection housing may be provided with a shutter for carrying in and out of the multi-well plate insertion unit.
- the present invention provides an adapter for mounting a conductive pipette for connecting the conductive pipette tip 1000 to the pipette device 1100, comprising: a cylinder body 1200 installed by being coupled to the pipette device 1100; Disclosed is an adapter for mounting a conductive pipette, which is coupled to the outer circumferential surface of the cylinder body (1200) and includes a cylindrical plate spring part (1300) into which the conductive pipette tip (1000) is fitted.
- the cylinder body 1200 and the plate spring part 1300 may be formed of a metal and a conductive polymer.
- the cylinder body 1200 includes an upper coupling part 1210 inserted and coupled to the pipette device 1100, a lower coupling part 1220 exposed to the outside and connected to the conductive pipette tip 1000; It connects between the upper coupling part 1210 and the lower coupling part 1220 and may include a central part 1230 formed with a smaller radius than the upper coupling part 1210 and the lower coupling part 1220 .
- the upper coupling portion 1210 includes a first upper stepped portion 1211 formed at an upper end and a smaller radius than the first upper stepped portion 1211 extending from a lower side of the first upper stepped portion 1211 . It may include a second upper step portion 1212 formed of.
- the lower coupling portion 1220 may include a plurality of lower step portions 1221 formed to be spaced apart from each other by a predetermined interval.
- the conductive pipette tip 1000 may further include an elastic member 1400 installed in the lower step portion 1221 to prevent leakage of the solution.
- the leaf spring part 1300 includes an annular part 1310 coupled to the upper coupling part 1210 side, and a plurality of wing parts 1320 having elasticity downward along the annular part 1310. can do.
- the plate spring part 1300 is provided such that the wing part 1320 is installed to be spaced apart from the outer peripheral surface of the central part 1230 so that it can be deformed by elasticity according to the coupling of the conductive pipette tip 1000.
- the annular part 1310 may be installed on the outer peripheral surface of the second upper step portion 1212 .
- the plate spring unit 1300 may have one end in contact with the PCB unit 1500 installed in the pipette device 1100 to check energization, and the other end connected to the conductive pipette tip 1000 .
- the adapter for mounting a conductive pipette, the sample tube opening/closing device, and the automatic sample analysis system according to the present invention have an advantage in that dispensing, extraction and purification of a biological sample, amplification and testing can be continuously and automatically performed.
- the adapter for mounting a conductive pipette, the sample tube opening/closing device, and the automatic sample analysis system according to the present invention automatically and continuously perform from dispensing to testing without user intervention, thereby shortening the testing time and contamination of the sample during intermediate movement. This has the advantage of avoiding problems.
- the adapter for mounting a conductive pipette, the sample tube opening/closing device, and the automatic sample analysis system according to the present invention automatically open and dispense the sample tube in which the biological sample is accommodated in a sealed state, thereby contaminating the biological sample. has the advantage of preventing
- the adapter for mounting a conductive pipette, the sample tube opening/closing device, and the automatic sample analysis system according to the present invention are capable of simultaneously performing tests on a plurality of biological samples or performing a plurality of heterogeneous tests on one biological sample at the same time.
- the adapter for mounting a conductive pipette, the sample tube opening/closing device, and the automatic sample analysis system according to the present invention are components that can be operated independently in parallel, and perform three different types of tests on one biological sample at the same time, or There is an advantage in that the examination time can be significantly shortened, such as simultaneously performing the examination on biological samples.
- the adapter for mounting a conductive pipette, the sample tube opening/closing device, and the automatic sample analysis system according to the present invention improve the conventional problem of being able to perform tests only in a negative pressure facility due to the risk of external leakage of harmful substances during virus testing, thereby eliminating spatial restrictions. There are advantages to overcoming.
- FIG. 1 is a perspective view schematically showing a state of an automatic sample analysis system according to the present invention.
- FIG. 2 is a plan view showing various trays inserted into the automatic sample analysis system of FIG. 1 .
- FIG. 3 is a side view showing an upper gripper, a biological sample dispensing unit, and a target material dispensing unit in the automatic sample analysis system of FIG. 1 .
- FIG. 4 is a perspective view showing an upper gripper of the sample tube opening/closing device in the automatic sample analysis system of FIG. 1 .
- FIG. 5 is an enlarged view showing a part of the upper gripper of the sample tube opening/closing device in the automatic sample analysis system of FIG. 4 .
- FIG. 6 is a front view showing the state of the biological sample dispensing unit in the automatic sample analysis system of FIG. 1 .
- FIG. 7 is a side view showing a lower gripper of the sample tube opening/closing device of the automatic sample analysis system of FIG. 1 .
- FIG. 8 is an enlarged view showing a partial state of the lower gripper of the sample tube opening and closing device of the automatic sample analysis system of FIG. 7 .
- FIG. 9 is a perspective view showing a lower gripper of the sample tube opening and closing device of the automatic sample analysis system of FIG. 1 .
- FIG. 10 is a view showing the state of the negative pressure forming unit of the automatic sample analysis system of FIG. 1 .
- FIG. 11 is a view showing an adapter for mounting a conductive pipette according to the present invention.
- FIG. 12 is a cross-sectional view illustrating an adapter for mounting a conductive pipette according to FIG. 11 .
- FIG. 13 is an exploded perspective view showing an adapter for mounting a conductive pipette according to FIG. 11 .
- FIG. 14 is a perspective view illustrating a state of a target material delivery unit in the automatic sample analysis system of FIG. 1 .
- FIG. 15 is a cross-sectional view showing a state of a target material transfer driver in the automatic sample analysis system of FIG. 14 .
- the automatic sample analysis system includes: a sample tube opening/closing device for automatically opening and closing the sealing member 12 of a sample tube 10 containing a biological sample; An automatic dispensing device (1) for dispensing a biological sample from a sample tube containing a biological sample in liquid form, and an automatic purification and extraction device (2) for purifying and extracting a target material from the biological sample obtained from the automatic dispensing device (1) and a nucleic acid amplification test device (3) for amplifying and measuring the target material obtained from the automatic purification and extraction device (2).
- any conventionally disclosed tube can be used without a separate limitation.
- the automatic tablet extraction device 2 is a configuration for purifying and extracting a target material from the biological sample obtained from the automatic dispensing device 1, and various configurations are possible.
- the automatic tablet extraction device 2 includes a second housing 500 forming a first internal space S1, and an automatic dispensing device 1 provided in the second housing 500 to be described later.
- An extraction unit 600 for purifying and extracting a target material from a biological sample received from It may include a target material delivery unit 700 to deliver to the nucleic acid amplification test device (3).
- the second housing 500 is a configuration that forms the first internal space S1, and may communicate with the housing part 100 of the automatic dispensing device 1 to be described later, and in more detail, the housing part 100 ) may be connected to the first internal space S1 to form the same space.
- a plurality of wells are formed to receive the biological sample through the target material delivery unit 700, the biological sample is dispensed in a specific column, and one or more reagents for purification and extraction of the target material Alternatively, the multi-well plate 40 for extraction in which the sample is embedded may be disposed.
- the second housing 500 is mounted on the target material delivery unit 700 as well as the multi-well plate 40 for extraction in the first internal space S1 and is extracted from the multi-well plate 30 for dispensing.
- Extraction pipette supplied with a disposable pipette tip for extraction to move the biological sample to the multi-well plate 40 for extraction and to move the target material extracted from the multi-well plate 40 for extraction to the nucleic acid amplification test device 3
- the tip rack 50 and the waste unit 60 may be additionally disposed.
- the multi-well plate 40 for extraction, the pipette tip rack 50 for extraction, and the waste unit 60 are respectively arranged on the second tray that can slide between the first internal space S1 and the external space.
- the second housing 500 may include a second door unit 510 so that the second tray can move between the outside and the outside, and through the second door unit 510, each accessory for extraction
- the well plate 40 , the pipette tip rack 50 for extraction, the waste unit 60 , etc. may move between the outside and the first internal space S1 .
- the second housing 500 is an extraction unit ( 600) may be further included.
- the extraction unit 600 any conventionally disclosed configuration for extracting a target material from a biological sample is applicable, and more specifically, a magnetic field in a specific column of the multi-well plate 40 for extraction including a magnet. It may include a magnetic field applying unit to apply, and a heating unit formed adjacent to the magnetic field applying unit to heat the same specific heat.
- the target material delivery unit 700 moves between the extraction unit 600 and the nucleic acid amplification testing device 3 and sucks the target material located in the extraction unit 600 and supplies it to the nucleic acid amplification testing device 3 .
- the configuration various configurations are possible.
- the target material delivery unit 700 may suck a biological sample from the multi-well plate 30 for dispensing, and supply the biological sample to the multi-well plate 40 for extraction.
- the target material delivery unit 700 is equipped with a plurality of pipette tips for extraction provided in the aforementioned extraction pipette tip rack 50, and the target material dispensed from the multi-well plate 30 for dispensing is sucked and extracted. It can be supplied to the multi-well plate 40 for extraction, and the target material extracted through the multi-well plate 40 for extraction can be supplied to the nucleic acid amplification device 3 in the same way.
- the target material delivery unit 700 may be provided in parallel to correspond to the multi-well plate 20 for a biological sample, and may be individually driven in the X-axis, Y-axis, and Z-axis, respectively.
- the target material transfer unit 700 includes a target material transfer pipette mounting unit 710 that is equipped with a plurality of extraction pipette tips at the same time and sucks and discharges a biological sample or a target material through the mounted extraction pipette tips; It may include a target material transfer pipette driver for individually driving the target material transfer pipette mounting unit 710 in the X-axis, Y-axis, and Z-axis, respectively.
- the target material transfer unit 700 includes a plurality of target material transfer pipette mounting units 710 and a target material transfer pipette mounting unit 710 in which the target material transfer pipette mounting units 710 are installed. It may include a plate 720 and a target material transfer driver 730 for driving the target material transfer plate 720 in the left-right direction, that is, in the Y-direction.
- the target material transfer unit 700 includes a target material transfer support unit 740 in which the target material transfer driving unit 730 is installed, and the target material transfer unit 700 for driving the target material transfer unit 700 forward and backward, that is, in the X direction. It may include a target material transfer driving pulley 750 and a driving pulley 760 for driving the target material transfer pipette mounting unit 710 .
- the target material transfer plate 720 and the target material transfer pipette mounting unit 710 through the target material transfer driver 730 among the target material transfer unit 700 will be described.
- the target material transfer plate 720 is integrally formed with the transfer plate 721 on which the target material transfer pipette mounting parts 710 are installed, and the transfer plate 721, and is in contact with a target material transfer driver 730 to be described later. It may include a moving contact 722 .
- the target material transfer driving unit 730 includes a cam portion 731 that moves the target material transfer plate 720 in the Y direction, that is, in the left and right direction through pressurized contact with the contact portion 722, and the cam portion 731.
- a rotation motor 732 connected to rotate the cam part 731, a rotation bearing 733 installed on a part of the cam part 731, and a guide part 741 installed below the contact part 722 to be described later It may include a guide moving unit 734 for guiding the left and right movement of the target material transfer plate 720 by moving through the.
- the target material transfer support unit 740 is installed on one side of the target material transfer plate 720 to support the target material transfer driver 730 , and the above-described guide moving unit 734 is installed to be movable to transfer the target material. It may include a guide part 741 for guiding the movement of the plate 720 , and a guide support part 742 integrally formed with the guide part 741 .
- the nucleic acid amplification test device 3 is a configuration for amplifying and measuring the target material obtained from the automatic purification extraction device 2, and various configurations are possible.
- the nucleic acid amplification test apparatus 3 may receive a target material from the target material delivery unit 700, amplify it and test it.
- the nucleic acid amplification test apparatus 3 may receive the target material from the target material delivery unit 700 to the test multi-well plate 70 in which a plurality of wells are formed to perform amplification and test.
- the nucleic acid amplification test apparatus 3 may include a third housing 800 forming a second inner space S2, and a second inner space formed by the third housing 800 at this time ( S2) may also be formed to communicate with the first internal space (S1).
- the first internal space (S1) for dispensing the biological sample and extracting the target material from the biological sample, and the second internal space (S2) for amplifying the extracted target material and performing the test are in communication with each other to form one space
- efficient automatic analysis of biological samples may be possible without user intervention.
- the nucleic acid amplification test apparatus 3 includes: a test housing forming a test space isolated from the outside; It may include a multi-well plate inserting unit into which a multi-well plate provided with a plurality of reaction tubes containing the target material extracted through the automatic purification extraction device (2) is inserted.
- the multi-well plate inserting part includes a support part for supporting the edge of the multi-well plate provided with a plurality of the reaction tubes, and the support part at the dispensing position of the automatic tablet extraction device 3 and the amplification position in the test housing It may include a multi-well plate driver driven between.
- the inspection housing may be provided with a shutter for carrying in and out of the multi-well plate insertion unit.
- the automatic dispensing device 1 moves between the sample tube opening and closing part, the pipette tip rack 80 and the multi-well plate 30 for dispensing, and sucks the biological sample in the sample tube 10 located in the sample tube opening and closing part.
- it may include a biological sample dispensing unit 400 for dispensing to the multi-well plate 30 for dispensing.
- the biological sample dispensing unit 400 moves between the lower gripper 200 , the pipette tip rack 80 and the multi-well plate 30 for dispensing, and the living body in the sample tube 10 positioned in the lower gripper 200 . It may be configured to suck a sample and dispense it to the multi-well plate 30 for dispensing.
- the biological sample dispensing unit 400 corresponding to the lower gripper 200, the upper gripper 300, and the multi-well plate 20 for a biological sample may be provided with at least three independently operable in parallel.
- the biological sample dispensing unit 400 can be individually driven in the X-axis, Y-axis, and Z-axis, respectively, and each driving unit can be applied in the same manner as each driving unit of the upper gripper 300 described above. .
- the biological sample dispensing unit 400 is moved in the front-rear direction from the original position through the front-rear movement guide 900 installed in the first inner space (S1) and the second inner space (S2) so as to move therethrough.
- the biological sample dispensing unit 400 is configured to move the biological sample from the multi-well plate 30 for dispensing located in the first internal space S1 to the multi-well plate 40 for extraction, so the first internal space You can move back and forth within (S1).
- the dispensing pipette 410 is equipped with disposable pipette tips from the pipette tip rack 80, sucks the biological sample in the sample tube 10, and dispenses the suctioned biological sample into the multi-well plate 30 for dispensing. It can be configuration.
- the dispensing pipette 410 is equipped with a disposable pipette tip supplied through the pipette tip rack 80, and is seated on the lower gripping part 310 in the mounted state to the sample tube in which the tube cap 12 is opened.
- the biological sample in (10) can be sucked and moved to be dispensed into the multi-well plate for dispensing (30).
- the dispensing pipette sensor unit 420 may be configured to control the amount of suction and dispensing of the dispensing pipette 410 for a biological sample.
- the dispensing pipette sensor unit 420 may include a pressure sensor 421 for measuring a pressure level for detecting clogging of the dispensing pipette 410 , and more specifically, the dispensing pipette 410 .
- the degree of pressure applied to the dispensing pipette 410 is measured to determine the clogging of the pipette tip, and it can be determined whether dispensing is complete.
- the pressure for dispensing the biological sample through the pipette tip can be equalized to maintain the same dispensing amount.
- the dispensing pipette sensor unit 420 may include a level sensor 422 that is mounted on the dispensing pipette 410 and detects that the dispensing pipette tip 411 accommodating the biological sample comes into contact with the biological sample liquid level.
- the biological sample dispensing unit 400 is equipped with disposable pipette tips from the pipette tip rack 80 to dispense the suctioned biological sample to the multi-well plate 30 for dispensing, in this process conductive pipette tips can be used
- the level sensor 422 senses the liquid level of the biological sample dispensed through the conductive pipette tip, so that quantitative dispensing can be performed.
- the biological sample dispensing unit 400 the dispensing pipette 410 is dispensing driven to move between the dispensing multi-well plate 30 from the sample tube 10 located in the first internal space (S1) It may include a pipette driving unit 430 for use.
- the dispensing pipette driving unit 430 may apply the same driving method as the above-described upper gripper driving unit 320 , and for guiding the driving in the process processing direction of the biological sample dispensing unit 400 , in the front-rear direction It may be driven through the movement guide 900 .
- the sample tube opening/closing device includes a housing 110 that forms a first internal space S1 isolated from the outside, and is provided in the housing 110 to accommodate a biological sample.
- a housing part 100 including a door part 120 for introducing and taking out the multi-well plate 20 for a biological sample provided with a plurality of sample tubes 10; It is spaced apart from the multi-well plate 20 for the biological sample and installed in the inner space, and includes a sample tube opening and closing part that automatically opens and closes the sample tube 10 .
- the sample tube opening/closing unit includes at least one lower gripper 200 for gripping the lower portion of the sample tube 10 and at least one upper gripper 300 for gripping the upper portion of the sample tube 10 .
- the biological sample to be extracted and tested according to the present invention includes a target material to be tested, and various configurations are possible.
- a biological sample may mean blood, urine, tissue, saliva, sputum, etc. containing a target material obtained from a living organism, and may further include a crushed suspension of animals and plants, a culture solution of microorganisms, and a suspension. have.
- the target material is a target nucleic acid contained in a biological sample
- the automatic sample analysis system according to the present invention may amplify the target nucleic acid to perform a quantitative or qualitative test.
- the target material may be an antigen or antibody contained in a biological sample.
- the amplified nucleic acid may be an aptimeric nucleic acid or a nucleic acid of an antigen-nucleic acid conjugate selectively attached to an antigen or antibody included in the kit.
- the automatic sample analysis system can simultaneously quantitatively or qualitatively test each of the nucleic acids, antigens, and antibodies contained in a biological sample.
- the sample tube 10 according to the present invention is a configuration in which a biological sample extracted from a human body is accommodated, and any type of sample tube 10 disclosed in the prior art is applicable.
- the sample tube 10 is coupled to the tube body 11 in which the biological sample is accommodated and the upper part is opened, and the upper part of the tube body 11 is coupled through pressurization to seal the upper part of the tube body 11 .
- It includes a tube cap (12).
- the sample tube 10 may include a tube cap 12 coupled to the upper portion of the tube body 11 in order to seal the biological sample accommodated in the tube body 11 , at this time the tube cap (12), the tube body 11 and the screw type or may be a snap type coupled through simple pressure.
- the multi-well plate 20 for a biological sample is composed of a plurality of rows and columns in which the plurality of sample tubes 10 are seated, so that a plurality of wells can be formed.
- multi-well plate 20 for a biological sample three unit multi-wells in which 32 wells of 8 ⁇ 4 are formed are provided in parallel to form a total of 96 wells.
- the multi-well plate 20 for a biological sample like the above-described second tray, is seated on the first tray and can move between the external space and the internal space through the door part 120 to be described later.
- the multi-well plate 20 for a biological sample may be slidably moved while seated on the first tray, introduced into the inner space through the door unit 120 and taken out from the inner space.
- the dispensing multi-well plate 30 is disposed on the processing direction side from the biological sample multi-well plate 20 to the lower gripper 200 to be described later, and is passed through the biological sample dispensing unit 400 to the sample tube ( It may be configured to dispense and receive a biological sample from 1).
- the multi-well plate 30 for dispensing includes a plurality of multi-wells for dispensing and receiving a biological sample through the biological sample dispensing unit 400, and other necessary reagents or samples and extra biological samples for sample testing. It may include a buffer unit for positioning the back, and may include a pipette tip rack 80 mounted on the biological sample dispensing unit 400 to supply and discharge disposable pipette tips for moving a biological sample.
- the housing part 100 is a configuration that forms an internal space, and various configurations are possible.
- the housing unit 100 includes a housing 110 forming an internal space isolated from the outside, and a living body provided in the housing 110 and provided with a plurality of sample tubes 10 in which a biological sample is accommodated. It may include a door unit 120 for introducing and taking out the multi-well plate 20 for the sample.
- the housing unit 100 may include a UV lamp unit 130 provided on at least one of a lower surface of the inner space or an upper portion of the door unit 120 in the inner space.
- the housing unit 100 may include an ozone sensor 140 installed in the inner space to detect ozone generated by the UV lamp unit 130 .
- the housing unit 100 may include a negative pressure forming unit 150 for performing exhaust in one direction from the inner space to the outer space so that the inner space maintains a negative pressure state.
- the door unit 120 may be configured to introduce and take out the multi-well plate 20 for a biological sample provided in the housing 110 and provided with a plurality of sample tubes 10 in which the biological sample is accommodated.
- the door unit 120 may be configured to rotate a hinge so as to open and close the opening of the housing 110 , so that the first tray including the multi-well plate 20 for a biological sample is carried into the inner space. can do.
- the UV lamp unit 130 is provided on at least one of the lower surface of the inner space or the upper portion of the door unit 120 in the inner space, and various configurations are possible.
- the UV lamp unit 130 is provided on the lower surface of the inner space and the upper portion of the door unit 120, respectively, to sterilize and disinfect the multi-well plate 20 of the first tray brought in and out.
- the UV lamp unit 130 may be provided in at least one of the upper and lower surfaces of the second door unit 510 of the second housing 500 as well as the internal space.
- the ozone sensor 140 is installed in the inner space to detect ozone generated by the UV lamp unit 130 , and various configurations are possible.
- the ozone sensor 140 may detect ozone generated by being installed adjacent to the inner wall surface of the housing 110 constituting the inner space, in particular, at a position where the UV lamp unit 130 is provided.
- the negative pressure forming unit 150 may be configured to perform exhaust in one direction from the inner space to the outer space so that the inner space maintains a negative pressure state.
- the negative pressure forming part 150 is provided on one side of the housing part 100 and provided in front of the exhaust fan 151 for discharging air in the internal space and the exhaust fan 151 to the internal space. It may include an ozone filter 152 for filtering ozone present in the.
- the negative pressure forming unit 150 may be provided in the exhaust port 111 formed on one side of the housing 110 , and the exhaust fan 151 is located at the exhaust port 111 so as to be outside from the internal space. Air can be exhausted in one direction.
- the exhaust fan 151 discharges the air of the inner space, the first inner space S1, and the second inner space S2 communicating therewith to the outside, thereby forming a negative pressure in the inner space to form a door unit 120, Even when the first tray, the second tray, and the like are drawn in and out through the opening of the second door unit 520 , it is possible to prevent internal leakage of contaminants or materials to be analyzed.
- the ozone filter 152 may be provided in front of the exhaust fan 151 to filter ozone existing in the internal space.
- the ozone filter 152 may be provided in front of the inner space side of the exhaust fan 151 to allow air exhausted from the inner space through the exhaust fan 151 to pass therethrough.
- the ozone filter 152 can prevent ozone generated from the UV lamp unit 130 from being discharged to the outside and filter the ozone.
- the housing part 100 may further include an exhaust guide part 160 installed in the internal space to guide an air exhaust path from the internal space to the outside.
- the exhaust guide part 160 is vertically installed on one side opposite to the door part 120 of the first tray and the second tray of the internal space so that the air in the first internal space (S1) and the second internal space (S2) is discharged. It may guide so as to face the exhaust port 111 .
- the housing part 100 may include an outdoor air intake filter 190 installed on the upper surface to form an airflow in the inner space.
- the outdoor air intake filter 190 may be installed on the upper surface of the housing 110 to induce outdoor air to be supplied to the inner space, and a filter for filtering the passing outdoor air may be provided together.
- the outdoor air intake filter 190 can induce the formation of airflow in the internal space together with the internal circulation fan 180 to be described later, so that the airflow in the internal space is smoothly exhausted through the exhaust fan 151 . can induce
- the housing part 100 may include an internal circulation fan 180 provided on one end surface of the internal space to induce airflow in the internal space.
- the internal circulation fan 180 is provided on one end surface of the internal space and can form an air flow therein by driving, and through this, the external air filtered from the outside through the external air intake filter 190 and supplied is circulated in the internal space. , it may induce exhaust to be performed toward the exhaust fan 151 described above.
- the lower gripper 200 is spaced apart from the multi-well plate 20 for a biological sample and installed in the inner space, and is configured to grip the lower portion of the sample tube 10 by receiving the sample tube 10 .
- the lower gripper 200 corresponds to the multi-well plate 20 for a biological sample described above and is provided in parallel to grip the sample tube 10 so that the three tests are independently performed. have.
- the lower gripper 200 may include a lower gripping part 210 on which the sample tube 10 is seated and gripping the lower portion of the sample tube 10 ; It may include a lower gripper rotation driving unit 220 that rotates the lower gripping unit 210 around an imaginary center line passing through the center in the vertical direction of the sample tube 10 as an axis.
- the lower gripper 200 may include an identification code recognition unit 230 disposed adjacent to the lower gripping unit 210 to identify the biological sample by recognizing the identification code 13 . .
- the lower gripping part 210 is disposed adjacent to the multi-well plate 20 for a biological sample in the inner space, the sample tube 10 moving through the upper gripper 300 is seated, and the sample tube 10 is It may be configured to grip the lower part of the
- the lower gripping part 210 includes a plurality of lower gripping members 211 provided in the circumferential direction on the outer circumferential surface of the sample tube 10 based on the seating position of the sample tube 10 , and the lower gripping member.
- the 211 may include a lower gripping member driving unit 212 for driving the lower gripping member 211 to move in a radial direction based on the seating position of the sample tube 10 .
- the lower gripping part 210 is in close contact with the sample tube 10 to be gripped and a rubber fixing member 213 installed on the lower gripping member 211 to fix the sample tube 10 .
- a rubber fixing member 213 installed on the lower gripping member 211 to fix the sample tube 10 .
- the lower gripping part 210 horizontally moves the lower gripping member 211 in the direction of the sample tube 10 in a state where the sample tube 10 is seated at the seating position.
- the lower part can be gripped.
- the lower gripping member driving unit 212 is applicable to any type of driving disclosed in the prior art, for example, driving using an electric motor, a magnetic motor, and a gear, driving using a pulley and a belt, moving using electromagnetic It is possible to linearly move the lower holding member 211 through the back.
- the lower gripper rotation driving unit 220 may be configured to rotate an imaginary center line passing through the center in the vertical direction of the sample tube 10 as an axis.
- the lower gripper rotation driving unit 220 rotates the lower gripping unit 210 around an imaginary center line passing through the center in the vertical direction of the sample tube 10, thereby rotating the sample tube 10 in place. can make it
- the lower gripper rotation driving unit 220 rotates the tube body 11 of the sample tube 10 relative to the tube cap 12 gripped by the upper gripper 300 , thereby causing the sample tube 10 to rotate.
- the tube cap 12 can be separated from the tube body 11 .
- the tube body 11 can be automatically opened from the inside, which will be described in detail below.
- the lower gripper rotation driving unit 220 includes a lower gripper rotation driving source 221 providing a driving force according to rotation, one connected to the lower gripper rotation driving source 221 and the other connected to the lower gripper rotation driving source 210 . It may include a pair of lower gripper rotating pulleys 222 connected to each of which is coupled by a belt.
- the lower gripper rotation driving unit 220 when the lower gripper rotation driving source 221 provides rotational force to one lower gripper rotation pulley 222, the other lower gripper rotation pulley 222 connected through the belt is activated. It rotates, and the lower gripping part 210 coupled thereto can be rotated.
- the lower gripper 200 may further include an identification code recognition unit 230 for recognizing an identification code 13 for identifying a biological sample that is attached to the tube body 11 and accommodated therein.
- the identification code recognition unit 230 may be disposed adjacent to the lower green skin 210 , and identify the biological sample by recognizing the identification code 13 .
- the identification code recognition unit 230 is installed adjacent to the lower gripping unit, irradiates light toward the identification code 13, and receives the emitted light to recognize the identification code 13 ( 232 , and a reading unit 231 installed adjacent to the recognition unit 232 to read the identification code 13 recognized through the recognition unit 232 .
- the identification code recognition unit 230 may be configured to be rotatable about the lower gripping unit 210 and the seated sample tube 10 as a central axis, whereby the identification code attached to the tube body 11 . Regardless of the location of (13), it can be reliably identified.
- the identification code recognition unit 230 may be fixedly installed. In this case, when the upper gripper 300 moves the sample tube 10 from the multi-well plate 20 for a biological sample, the By aligning the positions to be positioned at the correct positions, it is possible to stably recognize the identification code.
- the identification code 13 any configuration is applicable as long as it is a configuration that can be identified through scanning, for example, a barcode, a QR code, etc. may be applied.
- the upper gripper 300 grips the upper part of the sample tube 10, and moves between the multi-well plate 20 for a biological sample and the lower gripper 200 to deliver the sample tube 10, respectively. It may be a configuration that
- the upper gripper 300 may be provided in parallel to correspond to the above-described multi-well plate 20 for a biological sample and the lower gripper 200 so that three can be individually driven.
- the upper gripper 300 may be linearly movable in the X-direction, Y-direction, and Z-direction, and each of the three upper grippers 300 may be independently driven individually.
- the upper gripper 300 includes an upper gripping part 310 for gripping the upper part of the sample tube 10 and moving the upper gripping part 310 along a front-back direction that is a process direction.
- An upper gripper vertical drive unit 340 for moving the upper gripping unit 310 in the vertical direction may be included.
- the upper gripping part 310 may be configured to grip the upper part of the sample tube 10 .
- the upper gripping part 310 holds the tube body 11 or the tube cap 12 of the sample tube 10, and in the same manner as the lower gripping member 211 described above, the sample tube 10 ), an upper gripping member 311 provided in plurality at positions corresponding to the outer circumferential surface of the sample tube 10, and an upper gripping member driving unit for driving the upper gripping member 311 in the radial direction of the sample tube 10 ( 312) may be included.
- the upper holding member 311 can stably hold the sample tube 10 by forming the friction part 313 on the contact surface of the sample tube 10 .
- the upper gripping part 310 is provided in a plurality of positions corresponding to the outer circumferential surface of the sample tube 1 and moves in the radial direction while adjacent to the sample tube 10 . can be grasped.
- the upper gripping member driving unit 312 may grip the sample tube 10 by horizontally moving the upper gripping member 311 through various methods disclosed in the prior art, such as the above-described lower gripping member driving unit 212 , or the sample tube 10 . ) can be released.
- the upper gripper front-rear driving unit 320 may be configured to move the upper gripping unit 310 in the front-rear direction, which is the process processing direction.
- the upper gripper front-rear driving unit 320 drives the upper gripping unit 310 in the front-rear direction through a belt connected to the upper gripping unit 310 and a pair of upper gripper front-rear driving pulleys connected through the belt.
- the upper gripper front and rear driving unit 320 includes a forward and backward movement guide 900 installed in the first inner space S1 and the second inner space S2 so that the upper gripping unit 310 passes through and moves. It can be driven in the forward and backward directions from the correct position.
- the upper gripper left and right driving unit 330 may be configured to move the upper gripping unit 310 in a left and right direction with respect to a process direction.
- the upper gripper left and right driving unit 330 may be a pair of pulleys and belts connected to the upper gripping unit 310 as described above, and as another example, may be driven left and right through a rotating screw.
- the upper gripper up-down driving unit 340 is configured to move the upper gripping unit 310 in the up-down direction, and may be driven by using the pulley and belt described above or, as another example, by using a rotating screw. .
- the sample tube 10 may be of a snap type in which the tube cap 12 is coupled to the tube body 11 in a screw type or by simply pressing.
- the lower gripping part 210 is held while the tube cap 12 is gripped through the upper gripping part 310 . ) can grip the lower portion of the tube body 11 seated through the.
- the tube cap 12 is in a state of being gripped by the upper gripping unit 310 .
- the tube cap 12 can rotate relative to the tube body 11 , whereby the tube cap 12 can be separated from the tube body 11 .
- the tube cap 12 can be opened by rotating the upper gripping part 310 in a state in which the tube body 11 is fixed and gripped through the lower gripping part 210 .
- the tube cap 12 when the tube cap 12 is coupled to the tube body 11 in a simple pressing manner, the tube cap 12 is gripped through the upper gripping part 310 as described above, and the lower gripping part ( The tube cap 12 can be opened by moving the upper gripping part 310 upward or moving the lower gripping part 210 downward while gripping the lower part of the tube body 11 through 210). have.
- the adapter for mounting a conductive pipette described below can be applied to various configurations for mounting a conductive pipette in an automatic sample analysis system. More specifically, it is installed in the biological sample dispensing unit 400 so that the mounting of the conductive pipette tip is stable. and can be induced to be easily implemented.
- the conductive pipette mounting adapter is a conductive pipette mounting adapter for connecting the conductive pipette tip 1000 to the pipette device 1100, and the pipette device 1100.
- a cylinder body 1200 that is coupled to and installed; It is coupled to the outer circumferential surface of the cylinder body 1200, and includes a cylindrical plate spring part 1300 into which the conductive pipette tip 1000 is fitted.
- the pipette device 1100 may be configured to move or dispense a solution accommodated in the conductive pipette tip 100 by coupling the conductive pipette tip 1000 .
- the pipette device 1100 may include a conductive element capable of confirming whether the conductive pipette tip 1000 is coupled, and for example, a PCB unit 1500 to be described later may be provided to enable energization.
- the cylinder body 1200 is a configuration that is installed by being coupled to the pipette device 1100, and various configurations are possible.
- the cylinder body 1200 includes an upper coupling part 1210 inserted and coupled to the pipette device 1100 , and a lower coupling part 1220 exposed to the outside and connected to the conductive pipette tip 1000 , and , it connects between the upper coupling part 1210 and the lower coupling part 1220 and may include a central part 1230 formed with a smaller radius than the upper coupling part 1210 and the lower coupling part 1220 .
- the upper coupling part 1210 is formed to extend from the lower side of the first upper stepped part 1211 formed at the upper end and the first upper stepped part 1211 and is higher than the first upper stepped part 1211 .
- a second upper step portion 1212 formed with a small radius may be included.
- the lower coupling portion 1220 may include a plurality of lower step portions 1221 formed to be spaced apart from each other at regular intervals in the vertical direction.
- the plate spring part 1300 may be coupled to the outer circumferential surface of the cylinder body 1200 and may have a cylindrical configuration in which the conductive pipette tip 1000 is fitted and coupled.
- the leaf spring part 1300 includes an annular part 1310 coupled to the upper coupling part 1210 side, and a wing part ( 1320) may be included.
- the plate spring part 1300 has a wing part 1320 installed to be spaced apart from the outer peripheral surface of the central part 1230 so that the annular part 1310 can be deformed by elasticity according to the coupling of the conductive pipette tip 1000 . ) may be installed on the outer peripheral surface of the second upper stepped portion 1212 .
- the plate spring part 1300 can induce the conductive pipette tip 1000 to be elastically and closely adhere to the position where the wing part 1320 is installed to enable stable coupling.
- the plate spring unit 1300 may have one end in contact with the PCB unit 1500 installed in the pipette device 1100 to check energization, and the other end connected to the conductive pipette tip 1000 .
- the cylinder body 1200 and the plate spring part 1300 may be formed of a metal and a conductive polymer.
- the adapter for mounting a conductive pipette according to the present invention may further include an elastic member 1400 installed on the lower step 1221 to prevent solution leakage in the conductive pipette tip 1000 .
- the elastic member 1400 is installed on the outer diameter of the lower step portion 1221 and is in close contact with the inner diameter of the conductive pipette tip 1000 , thereby preventing the solution contained in the conductive pipette tip 1000 from leaking.
- the elastic member 1400 may be additionally provided in the upper step portion 1211 .
- the adapter for mounting the conductive pipette may further include an adapter plate 1600 bolted to the lower end of the pipette device 1100 to easily remove the conductive pipette tip 1000 from the pipette device 1100 .
- the adapter plate 1600 is bolted to the lower end of the pipette device 1100, and when the adapter plate 1600 is removed in a state where the upper end of the conductive pipette tip 1000 is interfered with, the conductive pipette tip 1000 is induced to be removed together. can do.
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Abstract
Description
Claims (35)
- 외부와 격리된 내부공간을 형성하고, 생체시료가 수용되는 복수의 시료튜브(10)가 구비되는 생체시료용 멀티웰플레이트(20)를 도입 및 반출하기 위한 도어(120)를 포함하는 하우징(110)과;상기 생체시료용 멀티웰플레이트(20)로부터 이격되어 상기 내부공간에 설치되며, 상기 시료튜브(10)를 자동으로 열고 닫는 시료튜브개폐부를 포함하는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 1에 있어서,상기 시료튜브개폐부는,상기 시료튜브(10)의 하부를 그리핑하는 적어도 하나 이상의 하부그리퍼(200)와, 상기 시료튜브(10)의 상부를 그리핑하는 적어도 하나 이상의 상부그리퍼(300)를 포함하는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 2에 있어서,3개의 상기 시료튜브(10)에 대한 개폐를 동시에 수행하도록, 상기 하부그리퍼(200) 및 상기 상부그리퍼(300)는 각각 3개씩 병렬로 서로 대응되어 구비되는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 3에 있어서,상기 상부그리퍼(300)들은,각각 독립적으로 X방향, Y방향 및 Z방향으로 선형이동 가능한 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 4에 있어서,상기 상부그리퍼(300)는,상기 시료튜브(10)의 상부를 그리핑하는 상부그리핑부(310)와;상기 상부그리핑부(310)를 프로세스 처리방향인 전후 방향을 따라서 이동시키기 위한 상부그리퍼전후구동부(320)와;상기 상부그리핑부(310)를 프로세스 처리방향에 대하여 좌우 방향을 따라서 이동시키기 위한 상부그리퍼좌우구동부(330)와;상기 상부그리핑부(310)를 상하방향을 따라서 이동시키기 위한 상부그리퍼상하구동부(340)를 포함하는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 2에 있어서,상기 상부그리퍼(200)는,상기 하부그리퍼(300)가 상기 시료튜브(10) 하부를 그리핑한 상태에서, 시료튜브(10)를 밀폐하는 밀폐부재(12)를 그리핑하여 상승함으로써 상기 시료튜브(10)를 개방하는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 2에 있어서,상기 상부그리퍼(200)가 상기 시료튜브(10)를 밀폐하는 밀폐부재(12)를 그리핑하고 상기 하부그리퍼(300)가 상기 시료튜브(10) 하부를 그리핑한 상태에서, 상기 상부그리퍼(200)와 상기 하부그리퍼(300)의 상대회전을 통해 상기 시료튜브(10)를 개방하는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 2에 있어서,상기 하부그리퍼(200)는,상기 시료튜브(10)가 안착되고, 상기 시료튜브(10) 하부를 그리핑하는 하부그리핑부(210)와;상기 하부그리핑부(210)를 상기 시료튜브(10) 수직방향으로 중심을 지나는 가상의 중심선을 축으로 회전시키는 하부그리퍼회전구동부(220)를 포함하는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 8에 있어서,상기 하부그리퍼(200)는,상기 하부그리핑부(210)에 인접하도록 배치되어, 상기 시료튜브(10)에 부착된 식별코드(13)를 인식함으로써, 상기 생체시료를 식별하는 식별코드인식부(230)를 포함하는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 1에 있어서,상기 하우징(110)은,상기 내부공간(S)의 하부면 및 상기 도어(120) 상부 중 적어도 하나에 구비되는 UV램프부(130)를 포함하는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 10에 있어서,상기 하우징(110)은,상기 내부공간(S)에 설치되어 상기 UV램프부(130)에 의해 발생되는 오존을 감지하는 오존센서(140)를 포함하는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 1에 있어서,상기 하우징(110)은,상기 내부공간(S)이 음압상태를 유지하도록, 상기 내부공간(S)으로부터 외부공간 일방향으로 배기를 수행하는 음압형성부(150)를 포함하는 것을 특징으로 하는 시료튜브개폐장치.
- 청구항 12에 있어서,상기 음압형성부(150)는,상기 하우징(110) 일측면에 구비되어 상기 내부공간(S)의 공기를 배출하는 배출팬(151)과, 상기 배출팬(151) 전방에 구비되어 내부공간(S)에 존재하는 오존을 필터링하는 오존필터(152)를 포함하는 것을 특징으로 하는 시료튜브개폐장치.
- 생체시료가 포함된 시료튜브(10)의 밀폐부재(12)를 자동으로 열고 닫는 청구항 제1항 내지 제13항 중 어느 하나의 항에 따른 시료튜브개폐장치와;상기 시료튜브(10)로부터 상기 생체시료를 분주하는 분주장치(1)와;상기 분주장치(1)로부터 수득한 상기 생체시료로부터 타겟물질을 정제 및 추출하는 자동정제추출장치(2)와;상기 자동정제추출장치(2)로부터 수득한 상기 타겟물질을 증폭하여 측정하는 핵산증폭검사장치(3)를 포함하는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 14에 있어서,상기 시료튜브개폐장치, 상기 분주장치(1) 및 상기 자동정체추출장치(2)는, 외부와 격리되는 제1내부공간(S1)을 형성하고,상기 핵산증폭검사장치(3)는, 외부와 격리되는 제2내부공간(S2)을 형성하며,상기 제1내부공간(S1) 및 상기 제2내부공간(S2)은,서로 연통되는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 14에 있어서,상기 타겟물질은,상기 생체시료에 포함되어 있는 타겟핵산이며,상기 타겟핵산을 증폭하여 정량 또는 정성 검사를 수행하는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 16에 있어서,상기 타겟핵산은,상기 생체시료에 포함되어 있는 항원 또는 항체 중 상기 항원 또는 항체에 선택적으로 부착되는 압타머핵산 또는 항원-핵산 결합체의 핵산인 것을 특징으로 하는 시료자동분석시스템.
- 청구항 14에 있어서,상기 생체시료에 포함되어 있는 핵산, 항원 및 항체 각각을 동시에 정량 또는 정성 검사하는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 14에 있어서,상기 분주장치(1), 상기 자동정제추출장치(2) 및 상기 핵산증폭검사장치(3)는 서로 분리되어 구분되는 도어를 각각 구비하는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 14에 있어서,상기 분주장치(1)는,상기 시료튜브개폐부, 피펫팁랙(80) 및 분주용 멀티웰플레이트(30) 사이를 이동하며, 상기 시료튜브개폐부에 위치하는 상기 시료튜브(10) 내 생체시료를 흡입하여 상기 분주용 멀티웰플레이트(30)에 분주하는 생체시료분주부(400)를 포함하는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 20에 있어서,상기 생체시료분주부(400)는,상기 시료튜브(10) 내 상기 생체시료를 흡입하고, 상기 분주용 멀티웰플레이트(30)에 흡입된 상기 생체시료를 분주하는 분주용피펫(410)과;상기 분주용피펫(410)의 상기 생체시료에 대한 흡입 및 분주 양을 조절하기 위한 분주용피펫센서부(420)와;상기 분주용피펫(410)이 상기 제1내부공간에 위치하는 상기 시료튜브(10)로부터 상기 분주용 멀티웰플레이트(30) 사이를 이동하도록 구동하는 분주용피펫구동부(430)를 포함하는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 21에 있어서,상기 분주용피펫센서부(420)는,상시 분주용피펫(410)의 막힘을 감지하기 위한 압력정도를 측정하기 위한 압력센서(421)를 포함하는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 21에 있어서,상기 분주용피펫센서부(420)는,상기 분주용피펫(410)에 장착되어 상기 생체시료가 수용되는 분주용피펫팁(411)이 상기 생체시료 액면에 접촉하는 것을 감지하는 레벨센서(422)를 포함하는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 14에 있어서,상기 핵산증폭검사장치(3)는,외부와 격리된 검사공간을 형성하는 검사하우징과;상기 자동정제추출장치(2)를 통해 추출된 타겟물질이 수용된 복수의 반응튜브들이 구비되는 멀티웰플레이트가 삽입되는 멀티웰플레이트삽입부를 포함하는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 24에 있어서,상기 멀티웰플레이트삽입부는,복수의 상기 반응튜브들이 구비되는 상기 멀티웰플레이트의 가장자리를 지지하는 지지부와, 상기 지지부를 상기 자동정제추출장치(3)의 분주위치와 상기 검사하우징 내 증폭위치 사이에 구동하는 멀티웰플레이트구동부를 포함하는 것을 특징으로 하는 시료자동분석시스템.
- 청구항 24에 있어서,상기 검사하우징은,상기 멀티웰플레이트삽입부의 반입반출을 위한 셔터가 구비되는 것을 특징으로 하는 시료자동분석시스템.
- 전도성피펫팁(1000)을 피펫장치(1100)에 연결하기 위한 전도성피펫 장착용 어댑터로서,상기 피펫장치(1100)에 결합하여 설치되는 실린더몸체(1200)와;상기 실린더몸체(1200) 외주면에 결합하며, 상기 전도성피펫팁(1000)이 끼워져 결합하는 원주형 판스프링부(1300)를 포함하는 것을 특징으로 하는 전도성피펫 장착용 어댑터.
- 청구항 27에 있어서,상기 실린더몸체(1200) 및 상기 판스프링부(1300)는,금속 및 전도성 고분자로 형성되는 것을 특징으로 하는 전도성피펫 장착용 어댑터.
- 청구항 27에 있어서,상기 실린더몸체(1200)는,상기 피펫장치(1100)에 삽입되어 결합하는 상부결합부(1210)와, 외부로 노출되며 상기 전도성피펫팁(1000)에 연결되는 하부결합부(1220)와, 상기 상부결합부(1210)와 상기 하부결합부(1220) 사이를 연결하며 상기 상부결합부(1210) 및 상기 하부결합부(1220)보다 작은 반경으로 형성되는 중심부(1230)를 포함하는 것을 특징으로 하는 전도성피펫 장착용 어댑터.
- 청구항 29에 있어서,상기 상부결합부(1210)는,상단에 형성되는 제1상부단차부(1211)와, 상기 제1상부단차부(1211)의 하측에서 연장 형성되며 상기 제1상부단차부(1211)보다 작은 반경으로 형성되는 제2상부단차부(1212)를 포함하는 것을 특징으로 하는 전도성피펫 장착용 어댑터.
- 청구항 29에 있어서,상기 하부결합부(1220)는,상호 일정간격 이격되어 형성되는 복수의 하부단차부(1221)를 포함하는 것을 특징으로 하는 전도성피펫 장착용 어댑터.
- 청구항 31에 있어서,상기 전도성피펫팁(1000) 내 용액 누수 방지를 위하여 상기 하부단차부(1221)에 설치되는 탄성부재(1400)를 추가로 포함하는 것을 특징으로 하는 전도성피펫 장착용 어댑터.
- 청구항 30에 있어서,상기 판스프링부(1300)는,상기 상부결합부(1210) 측에 결합하는 환형부(1310)와, 상기 환형부(1310)를 따라서 하측으로 탄성을 가지고 복수개 구비되는 날개부(1320)를 포함하는 것을 특징으로 하는 전도성피펫 장착용 어댑터.
- 청구항 33에 있어서,상기 판스프링부(1300)는,상기 날개부(1320)가 상기 중심부(1230) 외주면으로부터 이격되어 설치되어 상기 전도성피펫팁(1000) 결합에 따른 탄성에 의한 변형이 가능하도록 상기 환형부(1310)가 상기 제2상부단차부(1212) 외주면에 설치되는 것을 특징으로 하는 전도성피펫 장착용 어댑터.
- 청구항 27에 있어서,상기 판스프링부(1300)는,일단이 통전을 확인하기 위하여 상기 피펫장치(1100) 내에 설치되는 PCB부(1500)에 접촉하고, 타단이 상기 전도성피펫팁(1000)에 연결되는 것을 특징으로 하는 전도성피펫 장착용 어댑터.
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CN202180082398.6A CN116568402A (zh) | 2020-12-07 | 2021-12-07 | 导电性移液管安装用适配器、样品管开闭装置及样品自动分析系统 |
JP2023534306A JP2023553039A (ja) | 2020-12-07 | 2021-12-07 | 導電性ピペット装着用アダプタ、試料チューブ開閉装置及び試料自動分析システム |
CA3201537A CA3201537A1 (en) | 2020-12-07 | 2021-12-07 | Adapter for mounting conductive pipette, sample tube opening/closing device, and automatic sample analysis system |
EP21903799.1A EP4252908A1 (en) | 2020-12-07 | 2021-12-07 | Adapter for mounting conductive pipette, sample tube opening/closing device, and automatic sample analysis system |
US18/256,119 US20240053374A1 (en) | 2020-12-07 | 2021-12-07 | Adapter for mounting conductive pipette, sample tube opening/closing device, and automatic sample analysis system |
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CN117165401A (zh) * | 2023-11-02 | 2023-12-05 | 浙江正合谷生物科技有限公司 | 一种生物芯片多态操作设备、系统以及方法 |
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KR20090027671A (ko) * | 2006-05-29 | 2009-03-17 | 키아겐 게엠베하 | 피펫 팁 장착용 장치, 피펫 팁, 및 피펫팅 장치 |
KR20100061377A (ko) * | 2008-11-28 | 2010-06-07 | 에프. 호프만-라 로슈 아게 | 액체 샘플의 처리 시스템 및 처리 방법 |
KR20130092185A (ko) * | 2012-02-10 | 2013-08-20 | (주)바이오니아 | 생체시료의 자동 분석 장치 및 방법 |
KR102087861B1 (ko) * | 2019-09-20 | 2020-03-12 | (주)에스티아이 | 뚜껑 개폐 장치 및 이를 포함하는 케미컬 샘플링 장치 |
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2021
- 2021-12-07 KR KR1020210173561A patent/KR20220080722A/ko not_active Application Discontinuation
- 2021-12-07 CN CN202180082398.6A patent/CN116568402A/zh active Pending
- 2021-12-07 JP JP2023534306A patent/JP2023553039A/ja active Pending
- 2021-12-07 WO PCT/KR2021/018433 patent/WO2022124753A1/ko active Application Filing
- 2021-12-07 CA CA3201537A patent/CA3201537A1/en active Pending
- 2021-12-07 EP EP21903799.1A patent/EP4252908A1/en active Pending
- 2021-12-07 US US18/256,119 patent/US20240053374A1/en active Pending
Patent Citations (5)
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KR20010032485A (ko) * | 1997-11-26 | 2001-04-25 | 싸이버랩 인크. | 다채널 피펫팅 장치 |
KR20090027671A (ko) * | 2006-05-29 | 2009-03-17 | 키아겐 게엠베하 | 피펫 팁 장착용 장치, 피펫 팁, 및 피펫팅 장치 |
KR20100061377A (ko) * | 2008-11-28 | 2010-06-07 | 에프. 호프만-라 로슈 아게 | 액체 샘플의 처리 시스템 및 처리 방법 |
KR20130092185A (ko) * | 2012-02-10 | 2013-08-20 | (주)바이오니아 | 생체시료의 자동 분석 장치 및 방법 |
KR102087861B1 (ko) * | 2019-09-20 | 2020-03-12 | (주)에스티아이 | 뚜껑 개폐 장치 및 이를 포함하는 케미컬 샘플링 장치 |
Cited By (2)
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CN117165401A (zh) * | 2023-11-02 | 2023-12-05 | 浙江正合谷生物科技有限公司 | 一种生物芯片多态操作设备、系统以及方法 |
CN117165401B (zh) * | 2023-11-02 | 2024-01-26 | 浙江正合谷生物科技有限公司 | 一种生物芯片多态操作设备、系统以及方法 |
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US20240053374A1 (en) | 2024-02-15 |
CA3201537A1 (en) | 2022-06-16 |
CN116568402A (zh) | 2023-08-08 |
EP4252908A1 (en) | 2023-10-04 |
JP2023553039A (ja) | 2023-12-20 |
KR20220080722A (ko) | 2022-06-14 |
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