WO2022122489A1 - Ensemble de pistons d'injection pour un système d'analyse microfluidique, et procédé et outil de moulage par injection à cavités multiples pour la production de celui-ci - Google Patents

Ensemble de pistons d'injection pour un système d'analyse microfluidique, et procédé et outil de moulage par injection à cavités multiples pour la production de celui-ci Download PDF

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Publication number
WO2022122489A1
WO2022122489A1 PCT/EP2021/083672 EP2021083672W WO2022122489A1 WO 2022122489 A1 WO2022122489 A1 WO 2022122489A1 EP 2021083672 W EP2021083672 W EP 2021083672W WO 2022122489 A1 WO2022122489 A1 WO 2022122489A1
Authority
WO
WIPO (PCT)
Prior art keywords
injection
ram
carrier plate
cavity
plunger
Prior art date
Application number
PCT/EP2021/083672
Other languages
German (de)
English (en)
Inventor
Maxim Forst-Gill
Stephan Geise
Original Assignee
Robert Bosch Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102020215515.1A external-priority patent/DE102020215515A1/de
Priority claimed from DE102021212515.8A external-priority patent/DE102021212515A1/de
Application filed by Robert Bosch Gmbh filed Critical Robert Bosch Gmbh
Publication of WO2022122489A1 publication Critical patent/WO2022122489A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers

Definitions

  • Injection plunger package for a microfluidic analysis system and method and multi-cavity injection mold for its manufacture
  • the present invention relates to an injection plunger pack for emptying reagent bar chambers in a microfluidic analysis system and a microfluidic analysis system which has the injection plunger pack.
  • the present invention relates to a method and a multi-cavity injection mold for producing the injection ram assembly.
  • cartridges with differently filled reagent bars are used behind an elastic plastic membrane.
  • several injection rams drive against the plastic membrane with a defined force and speed and deform it with a certain amount of friction. This depends on the surface roughness of the respective injection ram surface.
  • they break open the seals of the different reagent bar chambers and the reagent liquids contained therein are injected into the intended analysis areas of the cartridge.
  • the injection plungers are usually manufactured from a metal part with a specially machined contour for different chamber geometries. They are then mounted in a specific position on a metal support plate using a screw connection.
  • DE 10 2019 200 109 A1 describes a microfluidic device and an analysis device for the microfluidic device.
  • An elastic membrane delimits a cavity in which an insert element is arranged.
  • the insert element is in the form of a reagent bar in which reagents for processing the microfluidic device are stored or pre-stored.
  • the membrane can be deformed by pressing an injection plunger in the form of a metal core against it by means of a moving element.
  • the injection plunger pack for emptying reagent bar chambers in a microfluidic analysis system has a plurality of injection plungers, also called reaction plungers, which are arranged on a support plate.
  • the injection rams each have a ram head with an arithmetic mean roughness value of less than 10.0 ⁇ m, preferably less than 4.0 ⁇ m, very preferably less than 1.0 ⁇ m and, according to a special embodiment, less than 0.1 ⁇ m (i.e less than 100 nm).
  • the arithmetic mean roughness value Ra is a measure of the roughness of the surface of the injection ram and can be measured according to the DIN EN ISO 4287:2010 standard.
  • the low surface roughness of the ram heads which is well below the surface roughness of injection rams made of metal by machining, causes very low friction losses when they come into contact with the membrane of a microfluidic analysis system. Deformation of the membrane without friction loss or adhesion allows for reliable injection of the contents of the reagent bar chambers into a designated analysis area of the microfluidic analysis system with constant force and velocity.
  • injection rams comprise a ram shaft and a ram head, the ram head being connected to the ram shaft. All the ram shafts are preferably manufactured in one piece with the carrier plate.
  • the injection ram package comprises a plurality of injection rams, ie at least two injection rams, the injection rams having a ram shank manufactured in one piece with the carrier plate, and at least one further injection ram, the ram shaft also having Injection plunger is not integrally connected to the support plate.
  • the one-piece connection of the plunger shafts to the carrier plate prevents the occurrence of tolerances that could occur when the injection plungers are subsequently attached to the carrier plate, so that simultaneous and uniform emptying of all reagent bar chambers is ensured.
  • the injection rams are manufactured in one piece with the carrier plate, in particular the injection rams are manufactured or formed completely in one piece with the carrier plate.
  • the one-piece connection of the injection plunger to the carrier plate prevents the occurrence of tolerances that could occur when the injection plunger is subsequently attached to the carrier plate, so that simultaneous and uniform emptying of all reagent bar chambers is ensured.
  • the subject matter of the invention is therefore also an injection plunger pack for emptying reagent bar chambers in a microfluidic analysis system, the injection plunger pack having a plurality of reaction plungers which are arranged on a support plate, and the reaction plungers having an arithmetic mean roughness value of less than 100 nm and being in one piece with the Carrier plate are made.
  • the carrier plate preferably has an arithmetic average roughness value of more than 0.2 ⁇ m, ie more than 200 nm, and particularly preferably an arithmetic average roughness value of more than 1.0 ⁇ m.
  • the ram heads are preferably made of a fluoropolymer, such as in particular polytetrafluoroethylene (PTFE), which in particular contains no fillers could be abrasive.
  • PTFE polytetrafluoroethylene
  • Thermoplastic fluoropolymers can also be easily processed by injection molding.
  • the injection ram package consists of a fluoropolymer, such as in particular polytetrafluoroethylene (PTFE), in particular when the injection ram is manufactured in one piece with the carrier plate.
  • PTFE polytetrafluoroethylene
  • the ram shafts and backing plate preferably comprise a plastic selected from the group consisting of polyamides, polyolefins, polybutylene terephthalate and polyoxymethylene. Furthermore, it is preferred that the ram shafts and the support plate have at least one filler selected from the group consisting of glass fibers, carbon fibers and mineral powder.
  • the material of the ram shafts and the carrier plate is therefore cheaper than the material of the ram heads. At the same time, it gives the injection ram assembly high mechanical stability, as it can exhibit less elasticity than the material of the ram heads.
  • the materials used for the ram heads, the ram shafts and the carrier plate also result in an injection ram pack that has a significantly reduced mass compared to conventional injection ram packs.
  • Each ram shank is preferably arranged partially in a cavity in a ram head and enters into a form fit with the ram head, preferably via a form fit with at least one, preferably several, undercuts of the ram head.
  • the undercuts can be produced, for example, by forced demolding or by rotary thread forming cores, which are used, for example, in the mass production of plastic lids for beverage bottles.
  • the tappet heads When worn, the tappet heads can later also be damaged by the Rotary thread and the elastic deformation of the anti-rotation device are exchanged if they are made of an elastic plastic without fillers, such as a fluoropolymer in particular.
  • each ram head has at least one anti-twist device, which is in engagement with a ram shank. In this way, twisting of the ram heads relative to the ram shafts is prevented if the plastic component of the ram heads does not adhere to the plastic component of the ram shafts.
  • two bores or domes per ram head can be provided as anti-twist protection.
  • the carrier plate has a plurality of connection openings. Screws, for example, can be passed through these connection openings, which are in particular circular-cylindrical and run parallel to the injection plungers, in order to connect the carrier plate to the actuating element.
  • the carrier plate has a plurality of engagement openings, each of which extends through the carrier plate into a ram shaft. Engagement elements of the actuating element can then be arranged in such a way that they extend into the engagement openings of the carrier plate.
  • the microfluidic analysis system has a number of cavities, each of which is set up to accommodate a reagent bar.
  • the cavities are each delimited by a membrane.
  • the injection plunger pack is arranged in the microfluidic analysis system such that each injection plunger faces a membrane. This allows him to deform the membrane to drain reagent bar chambers.
  • the microfluidic analysis system preferably has an actuating element for moving the injection plunger.
  • the carrier plate is connected to the actuating element by means of connection openings in order to be able to transfer its movement to the injection plunger.
  • engagement elements of Actuating elements are preferably arranged so that they extend into the engagement openings of the carrier plate.
  • the ram heads are produced by means of injection molding, in particular a first plastic mass. This process enables the ram heads to be manufactured quickly and with good reproducibility of the desired surface roughness.
  • the production preferably takes place in a first multi-cavity injection mold.
  • four or more ram heads can be manufactured in one cycle, which significantly reduces the cost per component.
  • the ram heads are then preferably used in a second multi-cavity injection mold.
  • the ram shafts and the carrier plate are then produced by introducing a second plastic mass into the second multi-cavity injection mold by means of injection molding in such a way that it fills a cavity in each ram head.
  • the ram heads and ram shafts can already be connected to one another during the manufacture of the ram shafts.
  • this procedure can be carried out without any problems for a large number of tappet shaft materials because of the thermal resistance of the fluoropolymer.
  • the ram heads are preferably fixed in the second multi-cavity injection mold by means of a negative pressure in order to hold them in their position.
  • the vacuum can be applied from the side of the ram heads that faces away from the ram shafts.
  • a first multi-cavity injection mold and a second multi-cavity injection mold adapted for use in the method are each further objects of this invention.
  • the entire injection ram package is alternatively produced by means of injection molding.
  • production preferably takes place in a multi-cavity injection mold.
  • Injection molds have a nozzle side that is firmly connected to a plasticizing unit of the injection molding machine, and an ejector side that can be separated from the nozzle side by means of ejector bolts in order to remove finished molded parts from the injection mold.
  • the injection rams are molded in the nozzle side of the multi-cavity injection mold and the carrier plate is molded in the ejector side of the multi-cavity injection mold.
  • FIG. 1 shows an isometric representation of an injection ram assembly according to an exemplary embodiment of the invention.
  • FIG. 2 shows a schematic sectional illustration of a microfluidic analysis system according to an exemplary embodiment of the invention.
  • FIGS. 3a-c show sectional views of ram heads according to different exemplary embodiments of the invention.
  • FIG. 4 shows a schematic sectional illustration of a multi-cavity injection mold according to an exemplary embodiment of the invention.
  • FIGS. 5a, b each show a schematic sectional illustration of further multi-cavity injection molds according to an exemplary embodiment of the invention.
  • FIG. 6 shows a schematic sectional illustration of a microfluidic analysis system according to an exemplary embodiment of the invention.
  • an injection ram package 10 which consists of a fluoropolymer, in the present embodiment of PTFE. It has nine injection rams 11, each with a ram head 12 and a ram shaft 13, as shown in FIG.
  • the injection rams 11 are arranged in three rows and three columns on a support plate 14 and their ram shanks 13, or alternatively the injection rams 11, are integrally connected thereto.
  • the carrier plate 14 has six connection openings 15 in order to be able to connect it to an actuating element of a microfluidic analysis system.
  • the arithmetic mean roughness value of the surface of the ram heads 12, or alternatively the injection ram 11, is less than 0.1 ⁇ m and the arithmetic mean roughness value of the surface of the ram shafts 13 and/or the carrier plate 14 is more than 1.0 ⁇ m or alternatively more than 200 nm .
  • FIG. 2 shows how the injection plunger package 10 can be installed in a microfluidic analysis system 20.
  • a substrate 21 delimits three cavities 22a-22c in the microfluidic analysis system 20, which is designed as a lab-on-chip.
  • the cavities 22a - 22c are further delimited on their underside by an elastic plastic membrane 23 .
  • a reagent bar with three reagent bar chambers is arranged in each of the cavities 22a-22c.
  • the foremost reagent bar chamber 30a-30c in each of the cavities 22a-22c is shown in FIG.
  • Below the membrane 23, the support plate 14 of the injection ram assembly 10 is arranged on an actuating element 24 that can be moved vertically.
  • the connection openings 15 of the carrier plate 14 are each arranged above recesses in the actuating element 24 .
  • connection openings 15a, 15b and two of the recesses 25a, 25b This is shown in FIG. 2 for two of the connection openings 15a, 15b and two of the recesses 25a, 25b.
  • screws, not shown which run through the connection openings 15a, 15b in the recesses 25a, 25b and engage there in a thread in the recesses 25a, 25b, is the Support plate firmly connected to the actuating element 24. If the actuating element 24 is moved upwards from a rest position in which the membrane 23 is not deflected, the injection plungers 11 deform the membrane 23 so that the situation shown in FIG. 2 results.
  • injection plunger 11a - 11c From each of the three rows of injection plungers 11, only the frontmost injection plunger 11a - 11c is shown, which deforms the membrane 23 in such a way that it pierces a seal in the frontmost reagent bar chamber 30a - 30c of each reagent bar and its contents so into an analysis area of the microfluidic analysis system injected.
  • the other injection plungers which cannot be seen in the section according to FIG. 2, simultaneously pierce the two other reagent bar chambers of each reagent bar and also inject their contents into the analysis area.
  • FIG. 3a shows an embodiment of undercuts 41 that were produced by forced demolding.
  • FIG. 3b shows an embodiment of undercuts 42 as rotary threads.
  • the ram head 11 shown also has two anti-rotation devices 43 in the form of domes.
  • FIG. 3c shows a further embodiment of undercuts 42 as rotary threads.
  • the ram head 11 shown also has two anti-rotation devices 44 in the form of bores.
  • the injection ram package 10 is produced in an injection molding process, in particular a production of an injection ram package 10 in which the injection rams (11, 11a-c) are manufactured in one piece with the carrier plate (12).
  • PTFE is melted in the plasticizing unit of an injection molding machine and injected through a nozzle into a temperature-controlled multi-cavity injection mold 70 by means of a screw.
  • the multi-cavity injection mold 70 is shown in FIG. In its nozzle side 71 it has nine cavities which correspond to the shape of the injection ram 11 . Its ejector side 72 has a cavity in the form of the carrier plate 14 on.
  • the ejector side 72 is separated from the nozzle side by means of ejector bolts and the injection ram package is ejected from the multi-cavity injection mold 70 by means of ejectors in the ejector side 72 of the latter.
  • the injection ram package 10 After the injection ram package 10 has completely cooled down, it can be installed in the microfluidic analysis system 20 without further processing.
  • the desired surface roughness of the injection ram 11 and the desired surface roughness of the support plate 14 is produced by the surface finish of the cavities of the multi-cavity injection mold 70 .
  • ram heads 12 are produced in their design according to FIG. 3c.
  • PTFE is melted in the plasticizing unit of an injection molding machine and injected through a nozzle into a first temperature-controlled multi-cavity injection mold 50 by means of a screw.
  • the first multi-cavity injection mold 50 is shown in FIG. 5a. It has an ejector side 51 and a nozzle side 52 .
  • Nine cavities 53 which correspond to the shape of the ram heads 12 are arranged in the ejector side 51 .
  • the desired surface roughness of the ram heads 12 is produced by the surface quality of the cavities 53 .
  • the ejector side 51 has an ejector 54 .
  • the nozzle side 52 has nine rotary thread forming cores 55 which each extend into one of the cavities 53 of the ejector side 51 .
  • the molten PTFE reaches the cavities 53 via a sprue 56 in the nozzle side 52.
  • the ejector side 51 is separated from the nozzle side 52 and the ram heads 12 are removed from the first multi-cavity injection mold 50 by means of the ejector 54 in the ejector side 51 ejected. After the ram heads 12 have completely cooled down, they are separated by removing the runners.
  • a second multi-cavity injection mold 60 is used to complete the injection ram pack 10 .
  • This is shown in FIG. 5b. It also has an ejector side 61 and a nozzle side 62 on.
  • a cavity in the form of the injection ram assembly 10 is formed in the ejector side 61 .
  • This has nine partial cavities, the shapes of which correspond to the individual injection plungers 11 .
  • one of the ram heads 12 is arranged in such a way that its cavity faces the nozzle side 62 .
  • Each ram head 12 contacts a channel 63 in the ejector side 61 in which an ejector 64 is arranged. The ejectors 64 do not fill the channels 63 completely.
  • a negative pressure is created in the channels 63, which can therefore hold the ram heads 12 in their position.
  • the cavity is then filled with a plastic melt through a hot runner 65 with needle valve 66 .
  • the plastic melt is produced, for example, by melting glass fiber reinforced PA6 in the plasticizing unit of an injection molding machine and feeding it through a nozzle into the hot runner using a screw.
  • the desired surface roughness of the ram shafts 13 and the carrier plate 14 is produced by the surface finish of the cavity. Projections on the nozzle side protrude into the partial cavities in such a way that an engagement opening 17 is formed in each ram shaft 13 and extends through the carrier plate 14 in each case.
  • the ejector side 62 is separated from the nozzle side 61 and the injection ram assembly 10 is ejected from the second multi-cavity injection mold 60 by means of the ejectors 64 in the ejector side 61 of the latter. After it has completely cooled down, the injection ram package 10 is assembled with the actuating element 24 .
  • connection openings 15a, 15b of the carrier plate 14 are each arranged above recesses 25a, 25b in the actuating element 24 in order to connect the carrier plate 14 to the actuating element 24.
  • the operating element 24 has nine engaging elements.
  • Three engagement elements 26a-26c are shown extending into the ram shafts 13a-13c. It is also shown that two projections 17a - 17c were formed on each of the ram shafts 13a - 13c during injection molding, which engage in the anti-rotation locks 44 of the ram heads 12 .

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)

Abstract

L'invention concerne un ensemble de pistons d'injection (10) pour vider des chambres à barre de réactif dans un système d'analyse microfluidique, comprenant une pluralité de plongeurs d'injection (11) qui sont disposés sur une plaque de support (14). Les pistons d'injection (11) ont chacun une tête de piston (12) ayant une valeur de rugosité moyenne arithmétique inférieure à 1,0 µm et un arbre de piston (13) formé d'un seul tenant avec la plaque de support (14). L'invention concerne également un système d'analyse microfluidique comprenant une pluralité de cavités qui sont chacune conçues pour recevoir une barre de réactif et qui sont chacune délimitées par une membrane. L'ensemble de pistons d'injection (10) est agencé de telle sorte que chaque piston d'injection (11) fait face à une membrane. Dans un procédé de production de l'ensemble de pistons d'injection (10), les têtes de piston (12) et/ou l'ensemble de pistons d'injection (10) sont produits au moyen d'un moulage par injection. L'outil de moulage par injection à cavités multiples est conçu pour être utilisé dans le procédé.
PCT/EP2021/083672 2020-12-09 2021-12-01 Ensemble de pistons d'injection pour un système d'analyse microfluidique, et procédé et outil de moulage par injection à cavités multiples pour la production de celui-ci WO2022122489A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102020215515.1 2020-12-09
DE102020215515.1A DE102020215515A1 (de) 2020-12-09 2020-12-09 Injektionsstößelpaket für ein Mikrofluidik-Analysesystem sowie Verfahren und Mehrkavitäten-Spritzgießwerkzeug zu seiner Herstellung
DE102021212515.8 2021-11-08
DE102021212515.8A DE102021212515A1 (de) 2021-11-08 2021-11-08 Injektionsstößelpaket für ein Mikrofluidik-Analysesystem sowie Verfahren und Mehrkavitäten-Spritzgießwerkzeug zu seiner Herstellung

Publications (1)

Publication Number Publication Date
WO2022122489A1 true WO2022122489A1 (fr) 2022-06-16

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102022207833A1 (de) 2022-07-29 2024-02-01 Robert Bosch Gesellschaft mit beschränkter Haftung Injektionsstößel, Injektionsstößelpaket und Verfahren zu seiner Herstellung, sowie Mikrofluidik-Analysesystem

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170058243A1 (en) * 2015-08-26 2017-03-02 EMULATE, Inc. Droplet fluid connections
WO2018102783A1 (fr) * 2016-12-01 2018-06-07 Novel Microdevices, Llc Dispositifs de point de soins automatisés pour le traitement d'échantillons complexes et leurs procédés d'utilisation
DE102019200109A1 (de) 2019-01-08 2020-07-09 Robert Bosch Gmbh Mikrofluidische Vorrichtung und Analysegerät für eine mikrofluidische Vorrichtung
WO2021018111A1 (fr) * 2019-07-29 2021-02-04 Bgi Shenzhen Co., Ltd. Cartouches de réactif pour dispositifs in vitro

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170058243A1 (en) * 2015-08-26 2017-03-02 EMULATE, Inc. Droplet fluid connections
WO2018102783A1 (fr) * 2016-12-01 2018-06-07 Novel Microdevices, Llc Dispositifs de point de soins automatisés pour le traitement d'échantillons complexes et leurs procédés d'utilisation
DE102019200109A1 (de) 2019-01-08 2020-07-09 Robert Bosch Gmbh Mikrofluidische Vorrichtung und Analysegerät für eine mikrofluidische Vorrichtung
WO2021018111A1 (fr) * 2019-07-29 2021-02-04 Bgi Shenzhen Co., Ltd. Cartouches de réactif pour dispositifs in vitro

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102022207833A1 (de) 2022-07-29 2024-02-01 Robert Bosch Gesellschaft mit beschränkter Haftung Injektionsstößel, Injektionsstößelpaket und Verfahren zu seiner Herstellung, sowie Mikrofluidik-Analysesystem

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