WO2022117835A3 - Vorrichtung zur aufnahme von mikroskopie-bildern - Google Patents

Vorrichtung zur aufnahme von mikroskopie-bildern Download PDF

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Publication number
WO2022117835A3
WO2022117835A3 PCT/EP2021/084206 EP2021084206W WO2022117835A3 WO 2022117835 A3 WO2022117835 A3 WO 2022117835A3 EP 2021084206 W EP2021084206 W EP 2021084206W WO 2022117835 A3 WO2022117835 A3 WO 2022117835A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
capturing
light source
microscopy images
sensor head
Prior art date
Application number
PCT/EP2021/084206
Other languages
English (en)
French (fr)
Other versions
WO2022117835A2 (de
Inventor
Philipp PAULITSCHKE
Original Assignee
Ludwig-Maximilians-Universität München
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102020132312.3A external-priority patent/DE102020132312A1/de
Application filed by Ludwig-Maximilians-Universität München filed Critical Ludwig-Maximilians-Universität München
Priority to US18/255,824 priority Critical patent/US20240111140A1/en
Priority to EP21830415.2A priority patent/EP4256388A2/de
Publication of WO2022117835A2 publication Critical patent/WO2022117835A2/de
Publication of WO2022117835A3 publication Critical patent/WO2022117835A3/de

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/0008—Microscopes having a simple construction, e.g. portable microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/086—Condensers for transillumination only
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/361—Optical details, e.g. image relay to the camera or image sensor
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/08—Synthesising holograms, i.e. holograms synthesized from objects or objects from holograms
    • G03H1/0866—Digital holographic imaging, i.e. synthesizing holobjects from holograms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Multimedia (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Computing Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Microscoopes, Condenser (AREA)

Abstract

Die Offenbarung betrifft Vorrichtungen zur Aufnahme von Mikroskopie-Bildern einer Probe, welche eine partiell kohärente Lichtquelle und einen Bildsensor mit Sensorkopf und Sensorausleseeinrichtung umfassen. Der Sensorkopf und die Lichtquelle sind derart angeordnet, dass der Sensorkopf und die Lichtquelle einen dazwischenliegenden Probenraum zur Aufnahme eines Substrats mit einer Probe definieren und dass eine optische Abbildung einer Probe in dem Probenraum durch die partiell kohärente Lichtquelle auf den Sensorkopf ein Intensitätsmuster darstellt. Des Weiteren betrifft die Offenbarung Systeme zur Überwachung einer Probe mit mehreren derartigen Vorrichtungen zur Aufnahme von Mikroskopie-Bildern.
PCT/EP2021/084206 2020-12-04 2021-12-03 Vorrichtung zur aufnahme von mikroskopie-bildern WO2022117835A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US18/255,824 US20240111140A1 (en) 2020-12-04 2021-12-03 Device for capturing microscopy images
EP21830415.2A EP4256388A2 (de) 2020-12-04 2021-12-03 Vorrichtung zur aufnahme von mikroskopie-bildern

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102020132312.3 2020-12-04
DE102020132312.3A DE102020132312A1 (de) 2020-12-04 2020-12-04 Vorrichtung zur Aufnahme von Mikroskopie-Bildern
DE102020132308.5 2020-12-04
DE102020132308 2020-12-04

Publications (2)

Publication Number Publication Date
WO2022117835A2 WO2022117835A2 (de) 2022-06-09
WO2022117835A3 true WO2022117835A3 (de) 2022-07-28

Family

ID=81853855

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2021/084206 WO2022117835A2 (de) 2020-12-04 2021-12-03 Vorrichtung zur aufnahme von mikroskopie-bildern

Country Status (3)

Country Link
US (1) US20240111140A1 (de)
EP (1) EP4256388A2 (de)
WO (1) WO2022117835A2 (de)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020102546A1 (en) * 2018-11-15 2020-05-22 The Regents Of The University Of California System and method for transforming holographic microscopy images to microscopy images of various modalities
DE102018129981A1 (de) * 2018-11-27 2020-05-28 Basler Ag Verarbeitung eines digitalen Intensitätsbildes: Verfahren, Speichermedium und Bildgebungssystem
WO2020117864A1 (en) * 2018-12-04 2020-06-11 The Regents Of The University Of California Portable uv holographic microscope for high-contrast protein crystal imaging
US20200232969A1 (en) * 2017-10-11 2020-07-23 Nanjing University Detection device based on shadow imaging of platelets, and method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200232969A1 (en) * 2017-10-11 2020-07-23 Nanjing University Detection device based on shadow imaging of platelets, and method thereof
WO2020102546A1 (en) * 2018-11-15 2020-05-22 The Regents Of The University Of California System and method for transforming holographic microscopy images to microscopy images of various modalities
DE102018129981A1 (de) * 2018-11-27 2020-05-28 Basler Ag Verarbeitung eines digitalen Intensitätsbildes: Verfahren, Speichermedium und Bildgebungssystem
WO2020117864A1 (en) * 2018-12-04 2020-06-11 The Regents Of The University Of California Portable uv holographic microscope for high-contrast protein crystal imaging

Also Published As

Publication number Publication date
WO2022117835A2 (de) 2022-06-09
US20240111140A1 (en) 2024-04-04
EP4256388A2 (de) 2023-10-11

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