WO2022053083A1 - Prothèse de valvule à deux valves ayant des volets de valvule - Google Patents

Prothèse de valvule à deux valves ayant des volets de valvule Download PDF

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Publication number
WO2022053083A1
WO2022053083A1 PCT/CN2021/129981 CN2021129981W WO2022053083A1 WO 2022053083 A1 WO2022053083 A1 WO 2022053083A1 CN 2021129981 W CN2021129981 W CN 2021129981W WO 2022053083 A1 WO2022053083 A1 WO 2022053083A1
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WO
WIPO (PCT)
Prior art keywords
valve
leaflets
prosthesis
ears
leaflet
Prior art date
Application number
PCT/CN2021/129981
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English (en)
Chinese (zh)
Inventor
钟生平
靳永富
Original Assignee
金仕生物科技（常熟）有限公司
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Publication of WO2022053083A1 publication Critical patent/WO2022053083A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/246—Devices for obstructing a leak through a native valve in a closed condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2463—Implants forming part of the valve leaflets

Definitions

  • the present application relates to the technical field of medical devices, and in particular, to a bicuspid valve prosthesis with valve ears.
  • the orifice of the heart valve will present a non-circular shape, and the ratio of its major diameter to its minor diameter will change within a certain range.
  • the shape of the mitral valve annulus is naturally non-circular, and the ratio of long and short diameters further increases during systole.
  • the traditional tri-leaflet valve prosthesis has a non-circular orifice, when the ratio of length to diameter varies within a certain range, the leaflets of the valve can still maintain a certain coaptation when the valve is closed, and no regurgitation occurs. However, when the ratio changes greatly, the valve leaflet will become abnormal due to excessive deformation of the valve frame, resulting in regurgitation.
  • the length-to-diameter ratio of the valve frame changes greatly, and the tricuspid valve cannot adapt to this change and causes severe regurgitation.
  • the present application relates to a bicuspid valve prosthesis with valve ears to solve the problem of regurgitation when the tricuspid valve prosthesis is closed in a non-circular state.
  • the purpose of this application is to provide a bicuspid valve prosthesis with valve ears, which includes:
  • valve frame wherein the valve frame is fixedly provided with a valve skirt
  • Two valve leaflets are arranged in the valve frame and are connected with the valve skirt;
  • Two flap ears are arranged in the flap holder, and the flap ear is protruded from the inner wall of the flap holder to the interior of the flap holder;
  • the bi-leaflet valve prosthesis with valve ears has an open state and a closed state, and in the closed state, between the two valve leaflets and the two valve leaflets are respectively connected with the two valve ears The passage of the bi-leaflet valve prosthesis is blocked after the abutment between them. In the open state, the two valve leaflets are separated from each other in the direction of approaching the valve frame, so as to open the passage.
  • the valve ear is away from the One end of the valve holder is formed with a bent portion.
  • the ratio between the length occupied by the valve ear in the circumferential direction of the valve holder and the length of the valve leaflet in the circumferential direction of the valve holder is in the range of 0.1 to 0.6.
  • the cross section of the valve holder is a non-circular structure, and has a long diameter and a short diameter, and the ratio of the long diameter to the short diameter is 1.05-1.50.
  • the cross section of the valve holder is a D-shaped or elliptical structure
  • the cross section of the valve holder has a long diameter and a short diameter, the two valve leaflets are respectively arranged on both sides of the long diameter, and the two valve ears are respectively arranged on both ends of the long diameter.
  • valve leaflet has a first free end
  • valve ear has a second free end
  • the second free end is flush with the first free end
  • the second free end The free end protrudes from the first free end.
  • the thickness of the leaflet is 0.25mm ⁇ 0.65mm.
  • the valve frame can make the two valve leaflets and the valve leaflets and the valve ears meet each other through the pushing action of blood in the flow during the systolic and diastolic process of the heart. Close the passage of the valve prosthesis, or drive the two valve leaflets and the valve leaflets and the valve ear to separate from each other to open the passage; wherein, when the valve prosthesis is in the closed state, the two valve leaflets can be maintained by the pushing force of the blood. In the closed state, at the same time, the length of the free edge of the valve leaflet required in the open and closed state is consistent through the matching design of the valve leaflet and the valve ear, thereby improving the closing performance of the valve prosthesis and preventing blood leakage.
  • FIG. 1 is a schematic structural diagram of a bicuspid valve prosthesis with valve ears provided in an embodiment of the present application
  • FIG. 2 is a state diagram of the bicuspid valve prosthesis with valve ears provided in an embodiment of the application in an open state
  • FIG. 3 is a state diagram of the bicuspid valve prosthesis with valve ears provided in an embodiment of the present application in a closed state;
  • FIG. 4 is a state diagram of the valve ear set in the valve holder.
  • connection can be a fixed connection, a detachable connection, or an integral Connection, or electrical connection; either directly or indirectly through an intermediary.
  • the embodiments of the present application provide a bi-leaflet valve prosthesis with valve ears, which includes a valve frame 1, a valve skirt, two valve leaflets 2 and two valve ears 3; wherein , the valve skirt is fixedly arranged in the interior of the valve frame 1, and specifically can be fixed and covered on the inner wall of the valve frame 1, two valve leaflets 2 are arranged in the valve frame 1, and are connected with the valve skirt; two valve ears 3 are arranged on the valve frame 1 In the frame 1, and the valve ear 3 protrudes from the inner wall of the valve frame 1 to the interior of the valve frame 1; wherein, the bicuspid valve prosthesis with the valve ear has an open state and a closed state, and in the closed state, the two flaps Between the leaflets 2 and between the two leaflets 2 and the two valve ears 3 respectively, the passage of the bi-leaflet valve prosthesis is blocked, and in the open state, the two leaflets 2 can move toward the direction close to the valve frame 1 separated from each other
  • the valve holder 1 has an inlet 11 and an outlet 12.
  • the valve leaflet 2 When the blood is flowing forward, it can enter from the inlet 11, and under the action of the blood flow, the valve leaflet 2 is opened, that is, the passage between the inlet 11 and the outlet 12 is opened, The blood can be discharged from the outlet 12, at this time, the valve prosthesis is in an open state; when the blood flows in the reverse direction, the valve leaflet 2 cooperates with the valve ear 3 to close the valve prosthesis, that is, the passage between the inlet 11 and the outlet 12 Closing, preventing blood from passing through the valve leaflets 2, at this time, the valve prosthesis is in a closed state.
  • the valve leaflet 2 is made of flexible material, and the edge of one end of the valve leaflet 2 away from the valve skirt forms a free edge, and the free edge can close or open the passage of the valve prosthesis after being pushed by the blood.
  • the valve leaflet 2 when the valve prosthesis is in the open state, the valve leaflet 2 can be close to the side wall of the valve frame 1 after deployment, and the passage of the valve prosthesis is opened after the two valve leaflets 2 are separated from each other;
  • Fig. 3 when the valve prosthesis is in a closed state, the passage of the valve prosthesis can be closed after the two valve leaflets 2 are abutted at the position between the two valve ears 3.
  • the two valve ears 3 can be symmetrically arranged at both ends of the long diameter of the valve prosthesis, the valve leaflets 2 can be connected with the valve skirt at the positions on both sides of the valve ears 3, and in the closed state, the valve leaflets 2 can be connected with the valve
  • the abutment of the ears 3 can make the valve leaflet 2 fully expand in the closed state, so that the length of the free side of the valve leaflet 2 in the open and closed states is consistent, thereby effectively improving the sealing effect of the valve prosthesis, avoiding the need for the problem of blood return.
  • valve leaflet 2 can be sewn on the valve skirt at the positions on both sides of the valve ear 3, without making the valve leaflet 2 sewn on the valve skirt and aligned with the long diameter Therefore, the length of the valve leaflet 2 is reduced, so that the valve leaflet 2 can be fully unfolded in the open or closed state, and the effective alignment between the two valve leaflets 2 and between the valve leaflet 2 and the valve ear 3 is ensured. It can improve the closing effect of the passage.
  • the leaflets of the valve can still maintain a certain coaptation when the valve is closed, and no regurgitation occurs.
  • the ratio changes greatly, the valve leaflet will become abnormal due to excessive deformation of the valve frame, resulting in regurgitation.
  • the length-to-diameter ratio of the valve frame also changes greatly, and the tri-leaflet valve cannot adapt to this change, causing severe regurgitation.
  • one way in the prior art is to increase the stiffness of the stent to resist deformation.
  • the tricuspid valve prosthesis may squeeze the aortic valve and make the aorta abnormal.
  • Another way is to solve the problem of regurgitation caused by the deformation of the tri-leaflet valve prosthesis by setting a double-layer stent.
  • Its structure is: the inner stent with a circular cross-section is connected with the outer stent, and three leaflets are fixed to the inner stent.
  • the diameter of the outer stent is larger than that of the inner stent, so that the outer stent can follow the
  • the heart is deformed by contraction and relaxation, and the deformation of the outer stent will not affect the inner stent during the deformation process, so that the cross section of the inner stent is always circular, ensuring that the trileaflet valve prosthesis has good closing performance.
  • the bicuspid valve prosthesis with valve ears provided by the present application, by setting two valve leaflets 2 and two valve ears 3, makes the valve frame 1 in the process of systole and diastole of the heart, and through the flow of blood
  • the pushing action can push the two valve leaflets 2 to match each other and the valve leaflets 2 and the valve ear 3 to match each other, so as to close the passage of the valve prosthesis, or drive the two valve leaflets 2 to separate from each other and the valve leaflets 2 and the valve ear 3 are separated from each other to open access.
  • the pushing force of blood can maintain the closed state between the two valve leaflets 2 and between the valve leaflets 2 and the valve ear 3, thereby improving the closure of the valve prosthesis performance, preventing blood leakage; that is, the two valve leaflets 2 and valve ears 3 in this application can achieve effective closure under any degree of deformation of the valve holder 1 to prevent blood backflow.
  • the single-layer valve stent 1 in this embodiment is convenient for implantation into the human body, and at the same time, the effective opening area of the valve prosthesis can be increased.
  • a bent portion 32 is formed at one end away from the valve holder 1.
  • the bending portion 32 can be an edge formed on the flap ear 3, the flap ear 3 is a flexible structure, and after the flap ear 3 is bent at a certain angle at the position of the bending portion 32, the flap ear 3 Both sides of 3 can be fixedly connected with the flap skirt, so that the two flap ears 3 are gathered from one side of the flap skirt to the bending portion 32 away from the flap skirt.
  • the valve ear 3 occupies a certain connection length on the valve holder 1, and the bent portion 32 at the end of the valve ear 3 away from the valve holder 1 can be formed on the long diameter of the valve prosthesis.
  • the above-mentioned valve holder 1 may be made of a shape memory alloy material, or may also be made of other elastic materials.
  • the valve holder 1 made of this material can be deformed, and can be deformed during the process of implanting the valve prosthesis into the human body, so that the valve prosthesis can be easily implanted into the human body through the input device. After entering the human body, the valve holder 1 of this material can be restored It is deformed and has a certain rigidity, so that it can be used to support the leaflet 2 .
  • valve leaflet 2 and the valve ear 3 are both flexible materials, the valve ear 3 can be pushed towards the valve leaflet 2 by the pushing force of the blood, and the valve leaflet 2 can be pushed towards the valve leaflet 2 by the pushing force of the blood.
  • the valve ear 3 can make the valve leaflet 2 and the valve ear 3 butt against each other, so as to realize the sealing of the passage.
  • the valve ear 3 basically maintains the same posture, and does not participate in the same opening and closing action as the valve leaflet 2 .
  • the ratio between the length occupied by the valve ear 3 in the circumferential direction of the valve holder 1 and the length of the valve leaflet 2 in the circumferential direction of the valve holder 1 is in the range of 0.1-0.6.
  • the length occupied by the valve ear 3 in the circumferential direction of the valve holder 1 is the connection length between the valve ear 3 and the valve holder 1
  • the length of the valve leaflet 2 in the circumferential direction of the valve holder 1 refers to the open state of the valve prosthesis, The cross-sectional length of the valve leaflet 2 when it is close to the valve frame 1 after it is fully deployed.
  • the specific ratio between the length occupied by the valve ear 3 in the circumferential direction of the valve holder 1 and the length of the valve leaflet 2 in the circumferential direction of the valve holder 1 may be 0.2, 0.3, 0.4 or 0.5.
  • a gap 31 is maintained between the two flaps 2 and the two flap ears 3 respectively.
  • the gap 31 can absorb the deformation along the long diameter direction of the valve prosthesis after the two valve leaflets 2 are pressed against each other, so as to ensure the effective closure of the valve prosthesis passage.
  • the cross section of the valve holder 1 can be a non-circular structure, and has a long The ratio of the major diameter to the minor diameter is 1.05-1.50.
  • the ratio of the long diameter to the short diameter may specifically be 1.1, 1.2, 1.3, 1.4, and the like.
  • the ratio of the long diameter to the short diameter of the valve holder 1 can be selected according to specific working conditions, as long as the long diameter and the short diameter of the valve holder 1 can be kept well sealed within this ratio range. Therefore, within this ratio range, the valve leaflet 2 can be maintained in a wide range of changes in the ratio of long and short diameters, which increases the fault tolerance of the valve prosthesis for the use environment, and better adapts to various long and short diameter ratios.
  • the cross section of the valve holder 1 can be a D-shaped or elliptical structure; the cross section of the valve holder 1 has a long diameter and a short diameter, and the two valve leaflets 2 are respectively arranged on both sides of the long diameter, The two flap ears 3 are respectively arranged at both ends of the long diameter.
  • each flap ear 3 is connected with the flap skirt, the bending portion 32 of the other end of each flap ear 3 can be formed on the straight line where the long diameter is located, and the flap ear 3 is located at two sides of the bending portion 32.
  • the side parts that match with the leaflets 2 can be located on both sides of the long diameter respectively.
  • the valve prosthesis is arranged at the mitral valve of the human body, and the valve prosthesis and the human aortic valve are opened and closed alternately, that is, when the aortic valve is opened, the valve prosthesis is closed, and the present
  • the cross-sectional area of the valve holder 1 is D-shape or ellipse, so that the valve prosthesis with D-shape or ellipse can avoid blocking the aortic valve when the valve prosthesis is deformed to the greatest extent.
  • the stability of the valve prosthesis implantation is improved due to the strong anti-deformation capability of the elliptical or D-shaped structure in the longitudinal direction.
  • the elliptical or D-shaped stent 1 structure can make the valve prosthesis work better, resulting in less regurgitation. It should be noted that, when the tri-leaflet valve prosthesis in the prior art includes three valve leaflets, the stent cannot be set to a non-circular structure, otherwise the tri-leaflet valve prosthesis cannot be closed.
  • valve leaflets 2 and two valve ears 3 are respectively disposed at opposite positions, so that the cross-section of the valve frame 1 can be a non-circular structure such as an oval or D-shaped structure, and The valve prosthesis can close normally.
  • the leaflet 2 has a first free end 21 , the above-mentioned free edge is formed at the edge of the first free end 21 , and the valve ear 3 has a second free end 33 , the second free end 33 is flush with the first free end 21 , or the second free end 33 protrudes from the first free end 21 .
  • first free end 21 is the end of the valve leaflet 2 that can close or open the passage by the pushing action of blood
  • second free end 33 is the end of the valve ear 3 that matches the first free end 21 .
  • the part of the valve leaflet 2 that is coinciding with the valve ear 3 can be completely fitted to the valve ear 3 .
  • making the second free end 33 protrude from the first free end 21 can prevent the valve leaflet 2 and the valve valve from being caused by the material characteristics or manufacturing errors of the valve leaflet 2 and the valve ear 3 during the manufacturing process of the valve prosthesis.
  • the fitting precision of the ear 3 is reduced, which affects the sealing effect of the valve prosthesis passage.
  • the cross section of the valve holder 1 when the cross section of the valve holder 1 is D-shaped or elliptical, the cross section of the valve holder 1 has a long diameter and a short diameter.
  • the valve holder 1 is located at the outlet 12
  • the ratio between the length of the minor axis at 2 and the height of the leaflet 2 is less than 2.1.
  • the height of the valve leaflet 2 refers to the height dimension of the valve leaflet 2 in the axial direction of the valve holder 1 .
  • the connection length between the valve leaflet 2 and the valve holder 1 in the axial direction is short, which leads to the valve leaflet 2 being easily leaked when it is compressed during the valve prosthesis closing process. , or the valve leaflet 2 is prone to inversion when being compressed, resulting in failure of the valve prosthesis.
  • the ratio between the length of the short diameter at the outlet 12 on the valve holder 1 and the height of the valve leaflet 2 is reduced, the force of the valve leaflet 2 is better, and the liquid is not easily leaked during the closing process, thereby further improving the The performance of valve prostheses.
  • the side wall of the valve frame 1 can be a grid structure or a wire frame structure such as a wire frame structure, and the valve frame 1 of the grid structure or wire frame structure is more easily deformed, so that it is more convenient to implant the valve prosthesis human body.
  • the valve skirt since the valve skirt is fixedly covered on the inner side of the valve holder 1, the grid structure or the wire frame structure of the valve holder 1 can be blocked, thereby preventing the blood entering the accommodating cavity from leaking from the grid structure.
  • the valve skirt can be a biological material or a flexible cloth.
  • the thickness of the leaflet 2 may be 0.25mm ⁇ 0.65mm. Specifically, the thickness of the leaflet 2 may be 0.3 mm, 0.4 mm, 0.5 mm, or the like. Of course, the actual thickness of the leaflet 2 can be set according to specific working conditions.
  • the two valve leaflets 2 and the two valve ears 3 can be arranged symmetrically or asymmetrically in the valve frame 1, and the two valve leaflets 2 can be of the same size and shape, or can be of the same size and shape. Structures with different shapes.
  • the material of the valve leaflet 2 may include biological material or artificial flexible material, for example, the artificial flexible material may be a plastic composite material or a material such as cloth, and the biological material may be a processed animal pericardium or the like.
  • the application can be used for aortic, pulmonary, tricuspid, and mitral valves. Its characteristics are especially suitable for interventional mitral valve.

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  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

La présente demande concerne une prothèse de valvule à deux valves ayant des volets de valvule (3), comprenant un cadre de valvule (1), une jupe de valvule (2), deux valves de valvule (3) et deux volets de valvule (3). Les deux valves de valvule (2) sont disposées à l'intérieur du cadre de valvule (1) et sont reliées à la jupe de valvule. Les deux volets de valvule (3) sont disposés à l'intérieur du cadre de valvule (1), et les volets de valvule (3) font saillie à partir de la paroi intérieure du cadre de valvule vers l'intérieur du cadre de valvule. Lorsque la présente prothèse de valvule est à l'état fermé, l'apposition entre les deux valves de valvule (2) et l'apposition respectivement entre les deux valves de valvule (2) et les deux volets de valvule (3) bloquent un passage de la prothèse de valvule, de façon à obtenir une étanchéité efficace du passage. À l'état ouvert, les deux valves de valvule (2) sont séparées l'une de l'autre dans une direction vers le cadre de valvule (1), de façon à permettre l'ouverture suffisante du passage. Pendant l'ouverture et la fermeture périodiques de la valvule, les volets de valvule (3) ne participent pas aux actions d'ouverture et de fermeture comme le font les valves de valvule (2). La conception de correspondance des valves de valvule (2) et des volets de valvule (3) permet de garantir la longueur du bord libre des valves de valvule (2) requise pour les états ouvert et fermé, de telle sorte que les valves de valvule (2) peuvent être complètement étirées lorsqu'elles sont ouvertes et fermées, et pendant ce temps, de bons effets d'ouverture et de fermeture peuvent être obtenus lorsque la valvule est en grande partie déformée.
PCT/CN2021/129981 2020-09-14 2021-11-11 Prothèse de valvule à deux valves ayant des volets de valvule WO2022053083A1 (fr)

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CN202010959505.6 2020-09-14
CN202010959505.6A CN111991119B (zh) 2020-09-14 2020-09-14 带瓣耳的二叶瓣瓣膜假体

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WO2022053083A1 true WO2022053083A1 (fr) 2022-03-17

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111991119B (zh) * 2020-09-14 2022-10-21 金仕生物科技（常熟）有限公司 带瓣耳的二叶瓣瓣膜假体

Citations (5)

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Publication number Priority date Publication date Assignee Title
US5147390A (en) * 1989-10-25 1992-09-15 Carbomedics, Inc. Heart valve prosthesis with improved bi-leaflet pivot design
US20050149181A1 (en) * 2004-01-07 2005-07-07 Medtronic, Inc. Bileaflet prosthetic valve and method of manufacture
CN101262833A (zh) * 2005-08-25 2008-09-10 爱德华兹生命科学公司 四叶带支架的二尖瓣心脏瓣膜
CN103687574A (zh) * 2011-02-25 2014-03-26 康涅狄格州大学 人工心脏瓣膜
CN111991119A (zh) * 2020-09-14 2020-11-27 金仕生物科技（常熟）有限公司 带瓣耳的二叶瓣瓣膜假体

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Publication number Priority date Publication date Assignee Title
DE19625202A1 (de) * 1996-06-24 1998-01-02 Adiam Medizintechnik Gmbh & Co Prothetische Mitral-Herzklappe
CN1160029C (zh) * 2002-03-29 2004-08-04 中南大学湘雅二医院 弹性瓣环心包二尖瓣
US9101467B2 (en) * 2012-03-30 2015-08-11 Medtronic CV Luxembourg S.a.r.l. Valve prosthesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147390A (en) * 1989-10-25 1992-09-15 Carbomedics, Inc. Heart valve prosthesis with improved bi-leaflet pivot design
US20050149181A1 (en) * 2004-01-07 2005-07-07 Medtronic, Inc. Bileaflet prosthetic valve and method of manufacture
CN101262833A (zh) * 2005-08-25 2008-09-10 爱德华兹生命科学公司 四叶带支架的二尖瓣心脏瓣膜
CN103687574A (zh) * 2011-02-25 2014-03-26 康涅狄格州大学 人工心脏瓣膜
CN111991119A (zh) * 2020-09-14 2020-11-27 金仕生物科技（常熟）有限公司 带瓣耳的二叶瓣瓣膜假体

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CN111991119B (zh) 2022-10-21

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