WO2022037646A1 - Detection system for immunodiagnostic analysis - Google Patents

Detection system for immunodiagnostic analysis Download PDF

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Publication number
WO2022037646A1
WO2022037646A1 PCT/CN2021/113525 CN2021113525W WO2022037646A1 WO 2022037646 A1 WO2022037646 A1 WO 2022037646A1 CN 2021113525 W CN2021113525 W CN 2021113525W WO 2022037646 A1 WO2022037646 A1 WO 2022037646A1
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Prior art keywords
module
reagent
cuvette
carrying
sample
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PCT/CN2021/113525
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French (fr)
Chinese (zh)
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吴栋杨
练子富
李临
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科美诊断技术股份有限公司
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Publication of WO2022037646A1 publication Critical patent/WO2022037646A1/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system

Definitions

  • the invention relates to the technical field of medical equipment, in particular to a detection system for immunodiagnostic analysis.
  • Chemiluminescence immunoassay is a non-radioactive immunoassay technology that has developed rapidly in recent years. This method has become one of the important directions of immunological detection. With the development of chemiluminescence immunoassay technology, the method of the reaction cup and the turntable mechanism has gradually replaced the method of the test strip, and the detection efficiency can be improved by the turntable mechanism.
  • the existing detection systems for immunodiagnostic analysis are complex in structure and difficult to meet high flexibility requirements in terms of timing scheduling and control.
  • the prior art incubation tray (or called a carrier tray) has a complicated design, resulting in a high degree of control crossover of each module and a long reaction process time, which cannot meet the needs of small users.
  • the incubation tray used by dade company please refer to Chinese patent CN1826218B
  • dade company includes double-layer test tube turntables 14, 16 and double-layer reagent turntables 26a, 26b, with three different reagent loading arms 60, 61, 62. Therefore, it is difficult to miniaturize the existing detection systems for immunodiagnostic analysis.
  • the present invention provides a detection system for immunodiagnostic analysis, which is used to solve the technical problems of complex structure and large volume of the detection system for immunodiagnosis analysis existing in the prior art.
  • the detection system for immunodiagnostic analysis of the present invention includes a carrying module for carrying a cuvette and an operating system, wherein the operating system includes a cuvette loading module and a sample-moving arm module that are sequentially arranged in the circumferential direction of the carrying module , light detection module, cuvette removal module and reagent arm;
  • the cuvette loading module, the sample transfer arm module, the reagent arm, the light detection module and the cuvette removal module respectively perform corresponding operations on the cuvette in the carrying module, thereby The chemical light reflection reaction is completed at the carrying module.
  • one side of the carrying module is provided with a reagent tray module for carrying reagents, and the reagent arm is disposed between the carrying module and the reagent tray module, so as to connect the reagent tray module
  • the reagents in the carrier module are transferred to the cuvette in the carrier module.
  • the resource station further includes a resource station corresponding to the movement range of the sample transfer arm module, the resource station includes a sample rack for carrying samples and a accommodating bin for carrying a sample needle, the sample rack
  • the accommodating compartment is arranged on the side of the carrying module away from the reagent tray in parallel with the accommodating compartment, and the accommodating compartment is arranged between the sample rack and the carrying module.
  • the cuvette loading module includes a reservoir for storing cuvettes, and the central axis of the reservoir is parallel to the center line connecting the carrier module and the reagent tray module.
  • the cuvette loading module includes a storage for storing the cuvette, and the central axis of the storage is perpendicular to the center line connecting the carrier module and the reagent tray module.
  • the light detection module and the cuvette removal module are both disposed on a side of the carrier module away from the cuvette loading module, and the light detection module is close to the sample holder, and The cuvette removal module is adjacent to the reagent tray module.
  • the number of the reagent arms is two, and the route of each of the reagent arms to transfer the reagent is an arc.
  • a cleaning tank is further provided between the carrying module and the reagent disk module, the cleaning tank is used for cleaning the reagent needles in the reagent arm, and the cleaning tank is provided in two of the on the transfer route of the reagent arm.
  • the detection system is a detection system for a chemiluminescence analyzer. That is, the detection system forms part of a chemiluminescence analyzer.
  • the detection system for immunodiagnostic analysis of the present invention has the advantages that: since a corresponding operating system is provided around the circumference of the carrier module, the operations of the reaction cup (such as adding samples, adding reagents and Incubation, etc.) can be completed on the carrier module, thus greatly simplifying the structure of the detection system for immunodiagnostic analysis, enabling the detection system for immunodiagnostic analysis to achieve the purpose of miniaturization; and making the detection process smoother and more concise .
  • FIG. 1 is a top view of a chemical immunoassay analyzer according to an embodiment of the present invention
  • Fig. 2 is the top view of the carrier module shown in Fig. 1;
  • Fig. 3 is the top view of the sample transfer arm module shown in Fig. 1;
  • FIG. 4 is a top view of a chemical immunoassay analyzer in another embodiment of the present invention.
  • each reference sign indicates:
  • 100-carrying module 110-operation position, 120-reaction cup; 130-rack; 140-housing; 150-application software; 121-reaction cup placing slot;
  • 200-Sampling arm module 202-Sampling arm; 203-Three-axis motion components;
  • 210-sample rack 220-emergency sample rack; 230-tip storage compartment; 231-discard tip area;
  • 600-light detection module 700-liquid circuit system; 800-control system; 900-reaction cup removal module.
  • Left side refers to the side along the negative direction of the X-axis shown in Figure 1
  • right side refers to the side along the positive direction of the X-axis shown in Figure 1
  • Front side refers to the side along the Y-axis shown in Figure 1
  • Rear side refers to the side along the negative direction of the Y-axis shown in Figure 1
  • upper side refers to the side along the Z-axis (not shown) orthogonal to the X-axis and the Y-axis, respectively. positive side.
  • the analyzer of the present invention includes a carrying module 100 for carrying the cuvette 120 and a reagent tray module 500 arranged on one side of the carrying module 100 , and the reagent tray module 500 carries a chemiluminescence reaction in the reagent tray module 500 .
  • reagent a chemiluminescence reaction in the reagent tray module 500 .
  • the number of the carrying module 100 and the reagent tray module 500 is one. Compared with the existing luminescence analyzer, all the steps of the chemiluminescence reaction test can be integrated in one incubation tray, so that the analyzer of the present invention can be completed.
  • the structure is simpler and more compact, enabling it to achieve the purpose of miniaturization.
  • the operations for the cuvette 120 include: the operation of pushing the cuvette 120 into the carrying module 100 , the operation of adding a sample to the cuvette 120 , and the operation of adding a diluent to the cuvette 120 One or more of the operations of adding reagents to the cuvette 120 , incubating and reading the cuvette 120 , optically detecting the cuvette 120 , and pushing the cuvette 120 out of the carrier module 100 .
  • the analyzer of the present invention is further provided with various operation units for realizing chemiluminescence reaction detection at positions corresponding to the operation positions around the carrier module 100 .
  • the operation unit includes a cuvette loading module 400 , a sample transfer arm module 200 , a light detection module 600 , a cuvette removal module 900 and a reagent arm 300 , which are sequentially arranged along the circumferential direction of the carrier module 100 .
  • the cuvette loading module 400 is used for arranging the disordered cuvette 120 neatly and then pushing it into the carrying module 100
  • the sample transfer arm module 200 is used for adding a sample to the cuvette 120 or sucking the diluted sample from the cuvette 120 .
  • the optical detection module 600 is used for optical detection of the substance in the cuvette 120
  • the cuvette removal module 900 is used to push the detection cuvette 120 on the carrier module 100 out of the carrier module 100
  • the reagent arm 300 is used to remove the reagent
  • the reagents in the disk module 500 are transferred to the cuvette 120 of the carrier module 100 .
  • the cuvette 120 rotates with the carrying module 100 to a position corresponding to each of the above-mentioned operation modules.
  • the number of the carrier module 100 is one. By arranging each component around its circumference to perform corresponding operations, the entire chemiluminescence reaction can be completed on one carrier module 100, thereby realizing the miniaturization of the analyzer and simplifying the scheduling control of the remaining components.
  • the bearing module 100 will be described in detail below.
  • the carrying module 100 includes a carrying plate with a disc-shaped structure, which can rotate around its axis.
  • a groove for carrying the cuvette 120 ie, the cuvette placement groove 121 described below
  • a plurality of grooves are provided along the circumference of the carrier disc.
  • the carrier module 100 also includes a housing that does not rotate with the carrier disk.
  • the casing of the carrying module 100 is provided with an operation position 110, so the position of the operation position is fixed relative to the main body of the analyzer.
  • An operation unit is provided at a position corresponding to the operation position 110, and the carrier module 100 makes the cuvette 120 in the cuvette placement groove 121 located at the operation position 110 through the rotation of the carrying plate, so that the operation unit corresponding to the operation position 110 can be used for the cuvette. 120 performs corresponding operations.
  • Different cuvette 120 can be located in different operation positions 110 at the same time through the rotation of the carrier plate, so that different cuvette 120 can be operated at the same time.
  • the operation positions 110 in the present invention include but are not limited to cup feeding position 1, first sample position 12, second sample position 16, detection position 30, cup discard position 41, first reagent position 56, second reagent position 69 and the third reagent position 72.
  • the numbers of these operation bits are for illustration only, and should not be construed as limiting the scope of protection of the present invention. Since the present invention starts from the cup feeding operation, the cup feeding position will be described first.
  • the cup feeding position 1 is located at the quarter quadrant point of the carrier module 100, and the cuvette loading module 400 is correspondingly provided at the cup feeding position 1.
  • the cuvette loading module 400 includes a cuvette storage module for storing cuvette 120 of the storage, as shown in FIG. 1 , the central axis of the storage is parallel to the line connecting the center of the carrier module 100 and the center of the reagent tray module 500 .
  • the cuvette loading module 400 makes the cuvette 120 in the cuvette enter the cuvette entry position 1 .
  • the sample position corresponds to the sample transfer arm module 200, and the sample transfer arm module 200 may be assigned to a plurality of sample loading positions.
  • the sample transfer arm module 200 is disposed between the cuvette loading module 400 and the sample holder 210 described below.
  • the number of sample bits is two, that is, a first sample bit (sample bit 12 as shown in FIG. 1 ) and a second sample bit 16 .
  • a first sample position may be used to add a sample
  • a second sample position may correspond to a diluted sample and aspirate the diluted sample.
  • the original sample in the first sample position is diluted by the instrument by a predetermined factor (eg, 20 times, 100 times, etc.) and then sent to the second sample position.
  • a predetermined factor e.g. 20 times, 100 times, etc.
  • the sample transfer arm can draw a certain amount of diluted sample from the second sample position and transfer it to the empty cuvette in the first sample position, so as to complete the subsequent reaction process.
  • the analyzer of the present invention saves components for diluting samples in conventional analyzers.
  • conventional analyzers there is generally a dedicated sample dilution area. Since the dilution of the sample generally requires a large dilution, additional dilution equipment is required to accommodate the large dilution of the sample volume.
  • the present application by using multiple sample positions on the carrier module to integrate the functions of sample addition and dilution at the same time, the component space is greatly saved.
  • sample bits can also be set. For example, set four sample bits.
  • the first and second sample positions are used to set the sample, and the third and fourth sample positions are used to accommodate the diluted sample.
  • the second to fourth sample positions are used to accommodate the diluted sample.
  • the reagent position is located at the intersection of the virtual arc with the fulcrum of the reagent arm 300 as the center and the carrier module 100 .
  • the virtual arc takes the fulcrum of the reagent arm as the center and the cantilever of the reagent arm as the radius.
  • the intersection of the virtual arc and the carrier module is the intersection of the virtual arc and the circular contour formed by the plurality of grooves. Therefore, the intersection with the carrier module corresponds to the groove.
  • the first reagent can be added to the reaction cup 120 at the first reagent position 56 .
  • the second reagent can be added to the cuvette 120 at the second reagent position 69, and the second reagent or the third reagent can be added to the cuvette 120 at the third reagent position 72.
  • the first reagent described in the present invention is not only one reagent, but may include a variety of different reagents.
  • it includes a first reagent R1, a first reagent R2, a first reagent R3, a diluent, and the like.
  • the reagent added to the second reagent position and the third reagent position is different from the reagent added to the first reagent position.
  • the second reagent position and the third reagent position can be used to add the same second reagent to the cuvette.
  • the analyzer selects the second reagent position or the third reagent position to add the same second reagent according to the time of the detection item.
  • the second reagent position is used for reagent additions for routine items.
  • the third reagent position is used for adding reagents for rapid detection items.
  • the second reagent described in the present invention is not only one reagent, but may include multiple reagents.
  • the second reagent R4 (such as a general reagent) and the second reagent R are included.
  • the reagents added to the second reagent site and the third reagent site are different from each other.
  • the third reagent position can be set for adding diluent, so that the first reagent position can provide more reagent.
  • the timing of the quick diagnosis item can be matched by the scheduling of the reaction vessel by the mechanical gripper.
  • the detection bit 30 corresponds to the light detection module.
  • the light detection module is arranged on the side of the carrying module away from the cuvette loading module, and the light detection module is close to the sample rack.
  • the light detection module 600 detects the luminescence signal of the cuvette 120 located at the detection position 30 (the cuvette 120 to which the corresponding reagent has been added).
  • the light detection module 600 is directly located on the detection position, so the light-emitting signal of the cuvette 120 directly enters the light detection module 600 for detection.
  • the light detection module 600 is not directly located on the detection position, but the luminescence signal of the cuvette 120 is collected and sent to the light detection module 600 by other means.
  • the cuvette removal module 900 on the carrier module 100 is disposed on the side of the carrier module away from the cuvette loading module, and the cuvette removal module is close to the reagent tray module.
  • the cuvette removal module enables the cuvette 120 located at the discarding position 41 to leave the carrier module 100 .
  • the cup feeding position, the first sample sample position 12 , the second sample position 16 , the detection position 30 , the cup discard position 41 , the first reagent position 56 , the second reagent position 69 and the third reagent in the operation position 110 Bit 72 is set sequentially in a counter-clockwise direction.
  • the operating position 110 can also be set in a clockwise direction, and it is only necessary to adjust the settings of other components of the instrument.
  • the second side (the right side as shown in FIG. 2 ) of the carrying module 100 is provided with a reagent disk module 500 for carrying reagents, and the number of reagent arms 300 is multiple. As shown in FIG. 1 , the route of each reagent arm 300 for transferring the reagent is an arc.
  • the number of intersections of the plurality of virtual arcs with each reagent arm as the center of the fulcrum and the carrier module 100 are different from each other.
  • the number of intersections of the plurality of virtual arcs centered on the fulcrum of each reagent arm and the reagent disk module 500 are different from each other.
  • the virtual arc takes the fulcrum of the reagent arm as the center and the cantilever of the reagent arm as the radius.
  • a virtual arc centered on the fulcrum of one of the reagent arms has two intersections with the carrier module 100 and one intersection with the reagent disk module
  • a virtual arc centered on the fulcrum of the other reagent arm has two intersections with the carrier module 100 One intersection and three intersections with the reagent disc module 500 .
  • the reagent suction position is located at the intersection of the virtual arc with the reagent arm 300 as the center and the reagent disk module 500 .
  • the sample transfer arm module 200 includes an interconnected sample transfer arm 202 and a drive system.
  • the drive system defines a translation range of the sample transfer arm 202, and the translation range can cover the sample loading position,
  • the sample rack 210 and the tip accommodating chamber 230 arranged in parallel with the sample rack 210 .
  • the drive system may be a three-axis motion assembly 203 .
  • the three-axis motion assembly 203 includes a Y-axis plane motion mechanism 205, an X-axis plane motion mechanism 204 connected with the Y-axis plane motion mechanism 205, and a Z-axis up-and-down motion mechanism 206 connected with the X-axis plane motion mechanism 204.
  • 202 is connected to the Z-axis up and down movement mechanism 206 .
  • the sample-moving arm 202 moves along the Z-axis under the driving of the Z-axis up-and-down movement mechanism 206 , and the sample-moving arm 202 and the Z-axis up-and-down movement mechanism 206 move along the X-axis under the driving of the X-axis plane movement mechanism 204 .
  • the arm 202 , the Z-axis up-and-down motion mechanism 206 and the X-axis plane motion mechanism 204 move along the Y-axis on the Y-axis plane motion mechanism 205 .
  • One of the columns (the right side as shown in FIG. 2 ) or one of the rows of the sample racks 210 can be set as the emergency sample racks 220 for carrying emergency sample test tubes, and other columns or other rows of the sample racks 210 can be set as the emergency sample racks 220 for carrying ordinary sample tubes.
  • the emergency sample in the emergency sample test tube can be transferred to the cuvette 120 in the carrying module 100 by the sample transfer arm module 200 in preference to the common sample in the common sample test tube.
  • the sample rack 210 and the tip accommodating chamber 230 utilize the space occupied by the three-axis motion assembly 203 in the XY plane, so that the volume of the analyzer can be further reduced.
  • the first reagent arm 310 and the second reagent arm 320 are respectively connected to the fluid circuit system 700 .
  • the liquid circuit system 700 can also provide washing liquid for the reagent arm 300, wherein the washing liquid is clean water and acid washing liquid.
  • the hydraulic system is also connected to the cleaning tank.
  • the cleaning tank includes a first needle washing tank for cleaning the reagent needles in the first reagent arm 310 and a second needle washing tank for cleaning the reagent needles in the second reagent arm 320 .
  • the analyzer further includes a control system 800, and the control system 800 is disposed on the left side of the rack 130 shown below.
  • the control system 800 is respectively connected with the sample rack 210 , the emergency sample rack 220 , the cuvette loading module 400 , the sample transfer arm module 200 , the tip storage compartment 230 , the carrying module 100 , the reagent tray module 500 , the first reagent arm 310 , and the second reagent
  • the arm 320 , the cup discarding module 900 , the liquid circuit system 700 and the light detection module 600 are electrically and communicatively connected, and are used to control the cooperation between the modules to perform corresponding operations.
  • the analyzer of the present invention further includes a rack 130 and a casing 140 disposed outside the rack 130 , the carrying module 100 and the operating unit are both disposed on the rack 130 , and the carrying module 100 is disposed in the middle of the rack 130 place.
  • the analyzer of the present invention also includes input and output components. Input and output components are provided on the housing 140 .
  • a reagent disk button is also provided at the lower right of the reagent disk module 500 to facilitate the operation of the reagent disk module 500 .
  • a second embodiment of the analyzer of the present invention which includes a carrier module 100 for carrying the cuvette 120 and a reagent tray module 500 arranged on one side of the carrier module 100 , wherein the carrier module The number of 100 and the reagent disk module 500 is the same.
  • the memory for storing the cuvette of the cuvette loading module 400 in this embodiment is arranged above the carrying module 100 and is perpendicular to the center line connecting the carrying module 100 and the reagent tray module. extend.
  • a reagent disk button 501 is also provided at the lower right of the reagent disk module 500 to facilitate the operation of the reagent disk module 500 .
  • the left side (or right side) of the rack 130 is further provided with a bracket 160 for supporting an all-in-one computer or an input and output device (not shown).
  • the control system 800 is also provided on the left side (or right side) of the rack 130 .

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Abstract

A detection system for immunodiagnostic analysis relating to the technical field of medical devices and used for solving the technical problems of complex structure and large volume of detection systems for immunodiagnostic analysis in the prior art. In the detection system for immunodiagnostic analysis, since a carrying module (100) is circumferentially provided with corresponding operating systems, operations with regard to a reaction cuvette (120) (for example, sampling adding, reagent adding and incubation, etc.) can be performed on the carrying module (100). Thus the structure of the detection system for immunodiagnostic analysis is significantly simplified, the detection system for immunodiagnostic analysis can be miniaturized, and the detection process is streamlined and simplified.

Description

一种用于免疫诊断分析的检测系统A detection system for immunodiagnostic analysis
相关申请的交叉引用CROSS-REFERENCE TO RELATED APPLICATIONS
本申请要求享有于2020年08月20日提交的中国专利申请CN202010842969.9以及于2020年12月15日提交的中国专利CN202011480106.8的优先权,上述申请的全部内容通过引用并入本文中。This application claims priority to Chinese patent application CN202010842969.9 filed on August 20, 2020 and Chinese patent CN202011480106.8 filed on December 15, 2020, the entire contents of which are incorporated herein by reference.
技术领域technical field
本发明涉及医疗设备技术领域,具体地说是一种用于免疫诊断分析的检测系统。The invention relates to the technical field of medical equipment, in particular to a detection system for immunodiagnostic analysis.
背景技术Background technique
化学发光免疫分析则是近年来发展较迅速的非放射性免疫检测技术,其原理是通过被测物与所添加的试剂发生的化学发光反应,采集被测物所发射的光并根据其发光强度测定待测物的浓度,该法已成为免疫学检测的重要方向之一。随着化学发光免疫分析技术的发展,反应杯以及转盘机构的方式已经逐渐替代了试验板条的方式,通过转盘机构能够提高检测的效率。Chemiluminescence immunoassay is a non-radioactive immunoassay technology that has developed rapidly in recent years. This method has become one of the important directions of immunological detection. With the development of chemiluminescence immunoassay technology, the method of the reaction cup and the turntable mechanism has gradually replaced the method of the test strip, and the detection efficiency can be improved by the turntable mechanism.
但是现有的用于免疫诊断分析的检测系统结构复杂,在时序调度和控制方面难以满足高灵活性要求。尤其是现有技术的孵育盘(或称为承载盘),其设计繁复,导致各个模块的控制交叉度高,反应过程时间较长,不能满足小型用户的需要。例如dade公司采用的孵育盘(请参考中国专利CN1826218B)包括双层试管转盘14、16和双层试剂转盘26a、26b,设有三个不同的试剂加载臂60、61、62。因此现有的用于免疫诊断分析的检测系统难以实现小型化。However, the existing detection systems for immunodiagnostic analysis are complex in structure and difficult to meet high flexibility requirements in terms of timing scheduling and control. In particular, the prior art incubation tray (or called a carrier tray) has a complicated design, resulting in a high degree of control crossover of each module and a long reaction process time, which cannot meet the needs of small users. For example, the incubation tray used by dade company (please refer to Chinese patent CN1826218B) includes double-layer test tube turntables 14, 16 and double-layer reagent turntables 26a, 26b, with three different reagent loading arms 60, 61, 62. Therefore, it is difficult to miniaturize the existing detection systems for immunodiagnostic analysis.
发明内容SUMMARY OF THE INVENTION
本发明提供一种用于免疫诊断分析的检测系统,用于解决现有技术中存在的用于免疫诊断分析的检测系统的结构复杂、体积较大的技术问题。The present invention provides a detection system for immunodiagnostic analysis, which is used to solve the technical problems of complex structure and large volume of the detection system for immunodiagnosis analysis existing in the prior art.
本发明的用于免疫诊断分析的检测系统,包括用于承载反应杯的承载模块以及操作系统,所述操作系统包括在所述承载模块的周向上依次设置的反应杯加载 模块、移样臂模块、光检测模块、反应杯移除模块和试剂臂;The detection system for immunodiagnostic analysis of the present invention includes a carrying module for carrying a cuvette and an operating system, wherein the operating system includes a cuvette loading module and a sample-moving arm module that are sequentially arranged in the circumferential direction of the carrying module , light detection module, cuvette removal module and reagent arm;
其中,所述反应杯加载模块、所述移样臂模块、所述试剂臂、所述光检测模块和所述反应杯移除模块分别对所述承载模块中的反应杯进行相应的操作,从而在所述承载模块处完成化学反光反应。Wherein, the cuvette loading module, the sample transfer arm module, the reagent arm, the light detection module and the cuvette removal module respectively perform corresponding operations on the cuvette in the carrying module, thereby The chemical light reflection reaction is completed at the carrying module.
在一个实施方式中,所述承载模块的其中一侧设置有用于承载试剂的试剂盘模块,所述试剂臂设置在所述承载模块和所述试剂盘模块之间,从而将所述试剂盘模块中的试剂转移至所述承载模块中的反应杯中。In one embodiment, one side of the carrying module is provided with a reagent tray module for carrying reagents, and the reagent arm is disposed between the carrying module and the reagent tray module, so as to connect the reagent tray module The reagents in the carrier module are transferred to the cuvette in the carrier module.
在一个实施方式中,还包括与所述移样臂模块的运动范围对应的资源站,所述资源站包括用于承载样本的样本架和用于承载加样针的容纳仓,所述样本架和所述容纳仓并列地设置在所述承载模块远离所述试剂盘的一侧,且所述容纳仓设置在所述样本架和所述承载模块之间。In one embodiment, it further includes a resource station corresponding to the movement range of the sample transfer arm module, the resource station includes a sample rack for carrying samples and a accommodating bin for carrying a sample needle, the sample rack The accommodating compartment is arranged on the side of the carrying module away from the reagent tray in parallel with the accommodating compartment, and the accommodating compartment is arranged between the sample rack and the carrying module.
在一个实施方式中,所述反应杯加载模块包括用于存储反应杯的存储器,所述存储器的中心轴线平行于所述承载模块与所述试剂盘模块的中心连线。In one embodiment, the cuvette loading module includes a reservoir for storing cuvettes, and the central axis of the reservoir is parallel to the center line connecting the carrier module and the reagent tray module.
在一个实施方式中,所述反应杯加载模块包括用于存储反应杯的存储器,所述存储器的中心轴线垂直于所述承载模块与所述试剂盘模块的中心连线。In one embodiment, the cuvette loading module includes a storage for storing the cuvette, and the central axis of the storage is perpendicular to the center line connecting the carrier module and the reagent tray module.
在一个实施方式中,所述光检测模块和所述反应杯移除模块均设置在所述承载模块远离所述反应杯加载模块的一侧,且所述光检测模块靠近所述样本架,而所述反应杯移除模块靠近所述试剂盘模块。In one embodiment, the light detection module and the cuvette removal module are both disposed on a side of the carrier module away from the cuvette loading module, and the light detection module is close to the sample holder, and The cuvette removal module is adjacent to the reagent tray module.
在一个实施方式中,所述试剂臂的数量为两个,每个所述试剂臂转移所述试剂的路线均为弧线。In one embodiment, the number of the reagent arms is two, and the route of each of the reagent arms to transfer the reagent is an arc.
在一个实施方式中,所述承载模块与所述试剂盘模块之间还设置有清洗槽,所述清洗槽用于清洗所述试剂臂中的试剂针,所述清洗槽设置在两个所述试剂臂的转移路线上。In one embodiment, a cleaning tank is further provided between the carrying module and the reagent disk module, the cleaning tank is used for cleaning the reagent needles in the reagent arm, and the cleaning tank is provided in two of the on the transfer route of the reagent arm.
在一个实施方式中,所述检测系统是用于化学发光分析仪的检测系统。也就是说,该检测系统构成化学发光分析仪的一部分。In one embodiment, the detection system is a detection system for a chemiluminescence analyzer. That is, the detection system forms part of a chemiluminescence analyzer.
与现有技术相比,本发明的用于免疫诊断分析的检测系统,其优点在于:由于环绕承载模块周向设置有相应的操作系统,因此针对反应杯的操作(例如加样本、加试剂以及温育等)均能够在承载模块上完成,从而大大简化了用于免疫诊断分析的检测系统的结构,使用于免疫诊断分析的检测系统能够实现小型化的目 的;并使检测过程更流畅、简洁。Compared with the prior art, the detection system for immunodiagnostic analysis of the present invention has the advantages that: since a corresponding operating system is provided around the circumference of the carrier module, the operations of the reaction cup (such as adding samples, adding reagents and Incubation, etc.) can be completed on the carrier module, thus greatly simplifying the structure of the detection system for immunodiagnostic analysis, enabling the detection system for immunodiagnostic analysis to achieve the purpose of miniaturization; and making the detection process smoother and more concise .
上述技术特征可以各种适合的方式组合或由等效的技术特征来替代,只要能达到本发明的目的。The above technical features can be combined in various suitable ways or replaced by equivalent technical features, as long as the purpose of the present invention can be achieved.
附图说明Description of drawings
在下文中将基于仅为非限定性的实施例并参考附图来对本发明进行更详细的描述。其中:In the following the invention will be described in more detail on the basis of merely non-limiting examples and with reference to the accompanying drawings. in:
图1是本发明的一个实施例中化学免疫分析仪的俯视图;1 is a top view of a chemical immunoassay analyzer according to an embodiment of the present invention;
图2是图1所示的承载模块的俯视图;Fig. 2 is the top view of the carrier module shown in Fig. 1;
图3是图1所示的移样臂模块的俯视图;Fig. 3 is the top view of the sample transfer arm module shown in Fig. 1;
图4是本发明的另一个实施例中化学免疫分析仪的俯视图。4 is a top view of a chemical immunoassay analyzer in another embodiment of the present invention.
在图中,相同的构件由相同的附图标记标示。附图并未按照实际的比例绘制。In the figures, the same components are designated by the same reference numerals. The drawings are not drawn to actual scale.
图中,各附图标记表示:In the figure, each reference sign indicates:
100-承载模块;110-操作位、120-反应杯;130-机架;140-外壳;150-应用软件;121-反应杯放置槽;100-carrying module; 110-operation position, 120-reaction cup; 130-rack; 140-housing; 150-application software; 121-reaction cup placing slot;
1-进杯位;12-样本位;16-稀释位;22-第一读数位;25-第二读数位;30-检测位;41-弃杯位;56-第一试剂位;69-第二试剂位;72-第三读数位;1-Intake position; 12-Sample position; 16-Dilution position; 22-First reading position; 25-Second reading position; 30-Detection position; 41-Discard cup position; 56-First reagent position; 69- The second reagent position; 72- the third reading position;
200-移样臂模块;202-移样臂;203-三轴运动组件;200-Sampling arm module; 202-Sampling arm; 203-Three-axis motion components;
204-X轴平面运动机构;205-Y轴平面运动机构;206-Z轴上下运动机构;204-X-axis plane motion mechanism; 205-Y-axis plane motion mechanism; 206-Z-axis up and down motion mechanism;
210-样本架;220-急诊样本架;230-吸头容纳仓;231-弃吸头区;210-sample rack; 220-emergency sample rack; 230-tip storage compartment; 231-discard tip area;
300-试剂臂;310-第一试剂臂;320-第二试剂臂;330-清洗槽;300-reagent arm; 310-first reagent arm; 320-second reagent arm; 330-washing tank;
400-反应杯加载模块;400- reaction cup loading module;
500-试剂盘模块;501-试剂盘按钮;500-reagent tray module; 501-reagent tray button;
600-光检测模块;700-液路系统;800-控制系统;900-反应杯移除模块。600-light detection module; 700-liquid circuit system; 800-control system; 900-reaction cup removal module.
具体实施方式detailed description
以下将结合说明书附图和具体实施例对本发明做进一步详细说明。需要说明的是,只要不构成冲突,本发明中的各个实施例以及各实施例中的各个特征可以 相互结合,所形成的技术方案均在本发明的保护范围之内。The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. It should be noted that, as long as no conflict is formed, each embodiment of the present invention and each feature of each embodiment can be combined with each other, and the formed technical solutions are all within the protection scope of the present invention.
首先对本发明所述的方位术语进行定义。First, the orientation terms used in the present invention are defined.
“左侧”是指沿图1所示X轴负方向的一侧,“右侧”是指沿图1所示X轴正方向一侧;“前侧”是指沿图1所示Y轴正方向的一侧,“后侧”是指沿图1所示Y轴负方向的一侧;“上侧”是指沿与X轴和Y轴分别正交的Z轴(未示出)的正方向一侧。"Left side" refers to the side along the negative direction of the X-axis shown in Figure 1, "right side" refers to the side along the positive direction of the X-axis shown in Figure 1; "Front side" refers to the side along the Y-axis shown in Figure 1 One side in the positive direction, "rear side" refers to the side along the negative direction of the Y-axis shown in Figure 1; "upper side" refers to the side along the Z-axis (not shown) orthogonal to the X-axis and the Y-axis, respectively. positive side.
上述方位术语的定义均是以承载模块100作为参照而进行定义的。The definitions of the above-mentioned orientation terms are all defined with reference to the carrying module 100 .
可以理解地,上述方位术语的定义是基于附图所示的方位或位置关系,仅是为了便于描述本发明和简化描述,而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作,当被描述对象的绝对位置改变后,则该相对位置关系也可能相应地改变,因此不能理解为对本发明的限制。It can be understood that the definitions of the above-mentioned orientation terms are based on the orientation or positional relationship shown in the accompanying drawings, which are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, so as to For specific orientation structures and operations, when the absolute position of the described object is changed, the relative positional relationship may also be changed accordingly, so it should not be construed as a limitation on the present invention.
实施例1Example 1
如图1和2所示,本发明的分析仪包括用于承载反应杯120的承载模块100以及设置在承载模块100一侧的试剂盘模块500,试剂盘模块500中承载有用于实现化学发光反应的试剂。其中,承载模块100和试剂盘模块500的数量均为一个,与现有的发光分析仪相比,可以将化学发光反应测试的所有步骤集成在一个孵育盘处完成,从而使本发明的分析仪的结构更简单紧凑,使其实现小型化的目的。As shown in FIGS. 1 and 2 , the analyzer of the present invention includes a carrying module 100 for carrying the cuvette 120 and a reagent tray module 500 arranged on one side of the carrying module 100 , and the reagent tray module 500 carries a chemiluminescence reaction in the reagent tray module 500 . reagent. Wherein, the number of the carrying module 100 and the reagent tray module 500 is one. Compared with the existing luminescence analyzer, all the steps of the chemiluminescence reaction test can be integrated in one incubation tray, so that the analyzer of the present invention can be completed. The structure is simpler and more compact, enabling it to achieve the purpose of miniaturization.
需要说明的是,本发明所述的针对反应杯120的操作包括:将反应杯120推入承载模块100的操作、向反应杯120中加样本的操作、向反应杯120中加稀释液的操作、向反应杯120中加试剂的操作、对反应杯120进行温育和读数的操作、对反应杯120进行光学检测的操作以及将反应杯120推出承载模块100的操作中的一个或多个。It should be noted that the operations for the cuvette 120 according to the present invention include: the operation of pushing the cuvette 120 into the carrying module 100 , the operation of adding a sample to the cuvette 120 , and the operation of adding a diluent to the cuvette 120 One or more of the operations of adding reagents to the cuvette 120 , incubating and reading the cuvette 120 , optically detecting the cuvette 120 , and pushing the cuvette 120 out of the carrier module 100 .
在一个实施例中,本发明的分析仪还围绕承载模块100在与操作位对应的位置处设置有用于实现化学发光反应检测的各个操作单元。具体来说,操作单元包括沿承载模块100的周向方向依次设置的反应杯加载模块400、移样臂模块200、光检测模块600、反应杯移除模块900和试剂臂300。In one embodiment, the analyzer of the present invention is further provided with various operation units for realizing chemiluminescence reaction detection at positions corresponding to the operation positions around the carrier module 100 . Specifically, the operation unit includes a cuvette loading module 400 , a sample transfer arm module 200 , a light detection module 600 , a cuvette removal module 900 and a reagent arm 300 , which are sequentially arranged along the circumferential direction of the carrier module 100 .
其中,反应杯加载模块400用于将杂乱无序的反应杯120排列整齐后推入承载模块100中,移样臂模块200用于向反应杯120中添加样本或者从反应杯中吸 取稀释后的样本,光检测模块600用于对反应杯120中的物质进行光学检测,反应杯移除模块900用于将承载模块100上完成检测的反应杯120推出承载模块100,试剂臂300用于将试剂盘模块500中的试剂转移至承载模块100的反应杯120中。在本实施例中,反应杯120随承载模块100旋转到与上述各个操作模块所对应的位置处。Among them, the cuvette loading module 400 is used for arranging the disordered cuvette 120 neatly and then pushing it into the carrying module 100 , and the sample transfer arm module 200 is used for adding a sample to the cuvette 120 or sucking the diluted sample from the cuvette 120 . Sample, the optical detection module 600 is used for optical detection of the substance in the cuvette 120, the cuvette removal module 900 is used to push the detection cuvette 120 on the carrier module 100 out of the carrier module 100, and the reagent arm 300 is used to remove the reagent The reagents in the disk module 500 are transferred to the cuvette 120 of the carrier module 100 . In this embodiment, the cuvette 120 rotates with the carrying module 100 to a position corresponding to each of the above-mentioned operation modules.
当然也可以设想,通过机械抓手将反应杯移动至承载模块上的与上述各个操作模块对应的位置处,以实现化学发光反应。Of course, it is also conceivable to move the cuvette to a position on the carrying module corresponding to each of the above-mentioned operation modules by using a mechanical gripper, so as to realize the chemiluminescence reaction.
承载模块100的数量为一个。通过环绕其周向设置各部件执行相应操作,能够在一个承载模块100上完成整个化学发光反应,从而实现分析仪的小型化,以及简化其余部件的调度控制。The number of the carrier module 100 is one. By arranging each component around its circumference to perform corresponding operations, the entire chemiluminescence reaction can be completed on one carrier module 100, thereby realizing the miniaturization of the analyzer and simplifying the scheduling control of the remaining components.
下面对承载模块100进行具体的说明。The bearing module 100 will be described in detail below.
以图2所示的承载模块100为例来进行说明,在本实施例中,承载模块100包括圆盘状结构的承载盘,其能够绕其轴线进行旋转。承载盘上设置有承载反应杯120的凹槽(即下文所述的反应杯放置槽121)。多个凹槽沿承载盘的环周设置。此外,承载模块100还包括外壳,该外壳不随承载盘进行旋转。Taking the carrying module 100 shown in FIG. 2 as an example for illustration, in this embodiment, the carrying module 100 includes a carrying plate with a disc-shaped structure, which can rotate around its axis. A groove for carrying the cuvette 120 (ie, the cuvette placement groove 121 described below) is provided on the carrier plate. A plurality of grooves are provided along the circumference of the carrier disc. In addition, the carrier module 100 also includes a housing that does not rotate with the carrier disk.
承载模块100的外壳上设置有操作位110,因此操作位相对于分析仪的主体是位置固定的。与操作位110对应的位置处设置有操作单元,承载模块100通过承载盘的旋转使反应杯放置槽121中的反应杯120位于操作位110,以便使与操作位110对应的操作单元对反应杯120进行相应的操作。通过承载盘的旋转可使不同的反应杯120在同一时刻位于不同的操作位110,这样针对不同的反应杯120就可同时进行不同的操作。The casing of the carrying module 100 is provided with an operation position 110, so the position of the operation position is fixed relative to the main body of the analyzer. An operation unit is provided at a position corresponding to the operation position 110, and the carrier module 100 makes the cuvette 120 in the cuvette placement groove 121 located at the operation position 110 through the rotation of the carrying plate, so that the operation unit corresponding to the operation position 110 can be used for the cuvette. 120 performs corresponding operations. Different cuvette 120 can be located in different operation positions 110 at the same time through the rotation of the carrier plate, so that different cuvette 120 can be operated at the same time.
本发明所述的操作位110包括但不限于进杯位1、第一样本位12、第二样本位位16、检测位30、弃杯位41、第一试剂位56、第二试剂位69和第三试剂位72。这些操作位的编号仅用于举例说明,其不应被理解为对本发明的保护范围的限制。由于本发明是从进杯的操作开始,因此先从进杯位进行说明。The operation positions 110 in the present invention include but are not limited to cup feeding position 1, first sample position 12, second sample position 16, detection position 30, cup discard position 41, first reagent position 56, second reagent position 69 and the third reagent position 72. The numbers of these operation bits are for illustration only, and should not be construed as limiting the scope of protection of the present invention. Since the present invention starts from the cup feeding operation, the cup feeding position will be described first.
一、进杯位1。1. Into the cup position 1.
如图2所示,进杯位1位于承载模块100的四分之一象限点处,在进杯位1处对应地设置有反应杯加载模块400,反应杯加载模块400包括用于存储反应杯120的存储器,如图1所示,该存储器的中心轴线平行于承载模块100的中心与 试剂盘模块500的中心的连线。反应杯加载模块400使其中的反应杯120进入进杯位1。As shown in FIG. 2, the cup feeding position 1 is located at the quarter quadrant point of the carrier module 100, and the cuvette loading module 400 is correspondingly provided at the cup feeding position 1. The cuvette loading module 400 includes a cuvette storage module for storing cuvette 120 of the storage, as shown in FIG. 1 , the central axis of the storage is parallel to the line connecting the center of the carrier module 100 and the center of the reagent tray module 500 . The cuvette loading module 400 makes the cuvette 120 in the cuvette enter the cuvette entry position 1 .
二、样本位。Second, the sample position.
样本位与移样臂模块200相对应,移样臂模块200可以配属有多个加样位。移样臂模块200设置在反应杯加载模块400和下文所述的样本架210之间。The sample position corresponds to the sample transfer arm module 200, and the sample transfer arm module 200 may be assigned to a plurality of sample loading positions. The sample transfer arm module 200 is disposed between the cuvette loading module 400 and the sample holder 210 described below.
在具体实施中,样本位的数量为两个,即第一样本位(如图1所示的样本位12)和第二样本位16。例如,第一样本位可以用于添加样本,第二样本位可以对应于稀释后的样本并吸取该已稀释样本。In a specific implementation, the number of sample bits is two, that is, a first sample bit (sample bit 12 as shown in FIG. 1 ) and a second sample bit 16 . For example, a first sample position may be used to add a sample, and a second sample position may correspond to a diluted sample and aspirate the diluted sample.
在样本需要稀释的情况下,第一样本位中的原始样本被仪器稀释预定倍数(例如20倍、100倍等)并随后送至第二样本位。移样臂此时可以从第二样本位吸取一定量已稀释的样本并将其移送到第一样本位的空反应杯中,以完成后续反应过程。In the event that the sample needs to be diluted, the original sample in the first sample position is diluted by the instrument by a predetermined factor (eg, 20 times, 100 times, etc.) and then sent to the second sample position. At this time, the sample transfer arm can draw a certain amount of diluted sample from the second sample position and transfer it to the empty cuvette in the first sample position, so as to complete the subsequent reaction process.
由此,本发明的分析仪节省了常规分析仪中用于稀释样本的组件。在常规分析仪中,一般设有专用的样本稀释区。因为样本的稀释一般需要大倍数稀释,由此需要额外的稀释设备,以用于容纳大倍数稀释后的样本体积。在样本需要稀释时,要首先将样本移动至稀释区进行稀释。完成稀释后的样本才被传送至承载盘进行后续步骤。而在本申请中,通过使用多个样本位在承载模块上同时集成了加样和稀释功能,大大节约了部件空间。Thus, the analyzer of the present invention saves components for diluting samples in conventional analyzers. In conventional analyzers, there is generally a dedicated sample dilution area. Since the dilution of the sample generally requires a large dilution, additional dilution equipment is required to accommodate the large dilution of the sample volume. When the sample needs to be diluted, first move the sample to the dilution area for dilution. The diluted sample is then transferred to the carrier tray for subsequent steps. However, in the present application, by using multiple sample positions on the carrier module to integrate the functions of sample addition and dilution at the same time, the component space is greatly saved.
当然,根据实际需要,还可以设置多于两个样本位。例如,设置四个样本位。此时,第一和第二样本位用于设置样本,第三和第四样本位用于容纳稀释后的样本。或者,如果所需的稀释倍数较大,也可以提出,第二至第四样本位均用于容纳稀释后的样本。Of course, according to actual needs, more than two sample bits can also be set. For example, set four sample bits. At this time, the first and second sample positions are used to set the sample, and the third and fourth sample positions are used to accommodate the diluted sample. Alternatively, if the required dilution factor is larger, it can also be proposed that the second to fourth sample positions are used to accommodate the diluted sample.
三、试剂位。3. Reagent position.
试剂位位于以试剂臂300的支点为圆心的虚拟圆弧与承载模块100的交点处。The reagent position is located at the intersection of the virtual arc with the fulcrum of the reagent arm 300 as the center and the carrier module 100 .
该虚拟圆弧以试剂臂的支点为圆心,以试剂臂的悬臂为半径。具体来说,该虚拟圆弧与承载模块的交点是其与多个凹槽所形成的圆形轮廓的交点。因此,与承载模块的交点即与凹槽对应。The virtual arc takes the fulcrum of the reagent arm as the center and the cantilever of the reagent arm as the radius. Specifically, the intersection of the virtual arc and the carrier module is the intersection of the virtual arc and the circular contour formed by the plurality of grooves. Therefore, the intersection with the carrier module corresponds to the groove.
其中,在第一试剂位56可向反应杯120添加第一试剂。在第二试剂位69可向反应杯120添加第二试剂,在第三试剂位72可向反应杯120添加第二试剂 或第三试剂。The first reagent can be added to the reaction cup 120 at the first reagent position 56 . The second reagent can be added to the cuvette 120 at the second reagent position 69, and the second reagent or the third reagent can be added to the cuvette 120 at the third reagent position 72.
本发明所述的第一试剂不仅仅是一种试剂,可能包括多种不同试剂。例如包括第一试剂R1、第一试剂R2、第一试剂R3、稀释液等等。The first reagent described in the present invention is not only one reagent, but may include a variety of different reagents. For example, it includes a first reagent R1, a first reagent R2, a first reagent R3, a diluent, and the like.
在此示例性地提出,第二试剂位和第三试剂位所添加的试剂不同于在第一试剂位添加的试剂。第二试剂位和第三试剂位可以用于向反应杯添加相同的第二试剂。Here, it is exemplarily proposed that the reagent added to the second reagent position and the third reagent position is different from the reagent added to the first reagent position. The second reagent position and the third reagent position can be used to add the same second reagent to the cuvette.
根据反应杯中的待测物所要进行的检测项目的不同,分析仪对应于检测项目时间选择第二试剂位或者第三试剂位来添加相同的第二试剂。例如,第二试剂位用于常规项目的试剂添加。而第三试剂位用于快速检测项目的试剂添加。由此,避免了不同项目之间的反应杯位置冲突,从而实现了不同检测项目时长的灵活匹配。According to the different detection items to be performed on the object to be tested in the reaction cup, the analyzer selects the second reagent position or the third reagent position to add the same second reagent according to the time of the detection item. For example, the second reagent position is used for reagent additions for routine items. The third reagent position is used for adding reagents for rapid detection items. As a result, the position conflict of the cuvette between different items is avoided, thereby realizing flexible matching of the duration of different detection items.
需要说明的是,本发明所述的第二试剂不仅仅是一种试剂,可能包括多种试剂。例如包括第二试剂R4(如通用试剂)、第二试剂R。It should be noted that the second reagent described in the present invention is not only one reagent, but may include multiple reagents. For example, the second reagent R4 (such as a general reagent) and the second reagent R are included.
也可以设想,第二试剂位与第三试剂位所添加的试剂彼此不同。此时,例如第三试剂位可以被设置用于添加稀释液,从而第一试剂位可以提供更多的试剂。在此情况下,快速诊断项目的时间可以通过机械抓手对反应容器的调度来实现匹配。It is also conceivable that the reagents added to the second reagent site and the third reagent site are different from each other. At this point, for example, the third reagent position can be set for adding diluent, so that the first reagent position can provide more reagent. In this case, the timing of the quick diagnosis item can be matched by the scheduling of the reaction vessel by the mechanical gripper.
四、检测位30。Fourth, the detection bit 30.
检测位30与光检测模块相对应。光检测模块设置在承载模块远离反应杯加载模块的一侧,且光检测模块靠近样本架。光检测模块600检测位于检测位30的反应杯120(已经添加有相应试剂的该反应杯120)的发光信号。The detection bit 30 corresponds to the light detection module. The light detection module is arranged on the side of the carrying module away from the cuvette loading module, and the light detection module is close to the sample rack. The light detection module 600 detects the luminescence signal of the cuvette 120 located at the detection position 30 (the cuvette 120 to which the corresponding reagent has been added).
需要说明的是,在一些实施方式中(如图1所示)光检测模块600直接位于检测位上,因此反应杯120的发光信号直接进入该光检测模块600中进行检测。It should be noted that, in some embodiments (as shown in FIG. 1 ), the light detection module 600 is directly located on the detection position, so the light-emitting signal of the cuvette 120 directly enters the light detection module 600 for detection.
可以理解地,在另一些实施方式中,光检测模块600并非直接位于检测位上,而是反应杯120的发光信号通过其他方式被采集且输送给光检测模块600。It can be understood that, in other embodiments, the light detection module 600 is not directly located on the detection position, but the luminescence signal of the cuvette 120 is collected and sent to the light detection module 600 by other means.
五、弃杯位41。5. Abandoned cup position 41.
承载模块100上的反应杯移除模块900设置在承载模块远离反应杯加载模块的一侧,且反应杯移除模块靠近试剂盘模块。反应杯移除模块使位于弃杯位41的反应杯120离开承载模块100。The cuvette removal module 900 on the carrier module 100 is disposed on the side of the carrier module away from the cuvette loading module, and the cuvette removal module is close to the reagent tray module. The cuvette removal module enables the cuvette 120 located at the discarding position 41 to leave the carrier module 100 .
在此,操作位110中的进杯位、第一样本样本位12、第二样本位16、检测位30、弃杯位41、第一试剂位56、第二试剂位69和第三试剂位72沿逆时针方向依次设置。Here, the cup feeding position, the first sample sample position 12 , the second sample position 16 , the detection position 30 , the cup discard position 41 , the first reagent position 56 , the second reagent position 69 and the third reagent in the operation position 110 Bit 72 is set sequentially in a counter-clockwise direction.
当然,操作位110也可沿顺时针方向设置,只需要调整仪器的其他部件设置即可。Of course, the operating position 110 can also be set in a clockwise direction, and it is only necessary to adjust the settings of other components of the instrument.
承载模块100的第二侧(如图2所示的右侧)设置有用于承载试剂的试剂盘模块500,试剂臂300的数量为多个。如图1所示,每个试剂臂300转移试剂的路线均为弧线。The second side (the right side as shown in FIG. 2 ) of the carrying module 100 is provided with a reagent disk module 500 for carrying reagents, and the number of reagent arms 300 is multiple. As shown in FIG. 1 , the route of each reagent arm 300 for transferring the reagent is an arc.
具体地,以每个试剂臂为的支点圆心的多个虚拟圆弧与承载模块100的交点数量彼此不同。此外,以每个试剂臂的支点为圆心的多个虚拟圆弧与试剂盘模块500的交点数量彼此不同。该虚拟圆弧以试剂臂的支点为圆心,以试剂臂的悬臂为半径。多个交点实现了仪器与不同检测项目时间的灵活匹配。仪器可以根据检测项目所需时间选择所需要的交点。Specifically, the number of intersections of the plurality of virtual arcs with each reagent arm as the center of the fulcrum and the carrier module 100 are different from each other. In addition, the number of intersections of the plurality of virtual arcs centered on the fulcrum of each reagent arm and the reagent disk module 500 are different from each other. The virtual arc takes the fulcrum of the reagent arm as the center and the cantilever of the reagent arm as the radius. Multiple intersection points realize the flexible matching of the instrument and the time of different inspection items. The instrument can select the required intersection point according to the time required for the inspection item.
例如,以其中一个试剂臂的支点为圆心的虚拟圆弧与承载模块100有两个交点并且与试剂盘模块有一个交点,以另一个试剂臂的支点为圆心的虚拟圆弧与承载模块100有一个交点并且与试剂盘模块500有三个交点。For example, a virtual arc centered on the fulcrum of one of the reagent arms has two intersections with the carrier module 100 and one intersection with the reagent disk module, and a virtual arc centered on the fulcrum of the other reagent arm has two intersections with the carrier module 100 One intersection and three intersections with the reagent disc module 500 .
试剂吸取位位于以试剂臂300为圆心的虚拟圆弧与试剂盘模块500的交点处。The reagent suction position is located at the intersection of the virtual arc with the reagent arm 300 as the center and the reagent disk module 500 .
在一个实施例中,如图3所示,移样臂模块200包括相互连接的移样臂202和驱动系统,驱动系统限定了移样臂202的平移范围,该平移范围能够覆盖加样位、样本架210和与样本架210并列设置的吸头容纳仓230。In one embodiment, as shown in FIG. 3 , the sample transfer arm module 200 includes an interconnected sample transfer arm 202 and a drive system. The drive system defines a translation range of the sample transfer arm 202, and the translation range can cover the sample loading position, The sample rack 210 and the tip accommodating chamber 230 arranged in parallel with the sample rack 210 .
驱动系统可以是三轴运动组件203。其中,三轴运动组件203包括Y轴平面运动机构205、与Y轴平面运动机构205相连的X轴平面运动机构204以及与X轴平面运动机构204相连的Z轴上下运动机构206,移样臂202设与Z轴上下运动机构206相连。The drive system may be a three-axis motion assembly 203 . The three-axis motion assembly 203 includes a Y-axis plane motion mechanism 205, an X-axis plane motion mechanism 204 connected with the Y-axis plane motion mechanism 205, and a Z-axis up-and-down motion mechanism 206 connected with the X-axis plane motion mechanism 204. 202 is connected to the Z-axis up and down movement mechanism 206 .
其中,移样臂202在Z轴上下运动机构206的驱动下沿Z轴方向运动,移样臂202和Z轴上下运动机构206在X轴平面运动机构204的驱动下沿X轴运动,移样臂202、Z轴上下运动机构206和X轴平面运动机构204在Y轴平面运动机构205沿Y轴运动。The sample-moving arm 202 moves along the Z-axis under the driving of the Z-axis up-and-down movement mechanism 206 , and the sample-moving arm 202 and the Z-axis up-and-down movement mechanism 206 move along the X-axis under the driving of the X-axis plane movement mechanism 204 . The arm 202 , the Z-axis up-and-down motion mechanism 206 and the X-axis plane motion mechanism 204 move along the Y-axis on the Y-axis plane motion mechanism 205 .
样本架210的其中一列(如图2所示的右侧)或者其中一行可以设置为用于 承载急诊样本试管的急诊样本架220,样本架210的其它列或者其他行可以设置为用于承载普通样本试管的普通样本架。急诊样本试管中的急诊样本可优先于普通样本试管中的普通样本通过被移样臂模块200转移至承载模块100中的反应杯120。One of the columns (the right side as shown in FIG. 2 ) or one of the rows of the sample racks 210 can be set as the emergency sample racks 220 for carrying emergency sample test tubes, and other columns or other rows of the sample racks 210 can be set as the emergency sample racks 220 for carrying ordinary sample tubes. Common sample holder for sample tubes. The emergency sample in the emergency sample test tube can be transferred to the cuvette 120 in the carrying module 100 by the sample transfer arm module 200 in preference to the common sample in the common sample test tube.
样本架210和吸头容纳仓230利用了三轴运动组件203在XY平面内所占用的空间,因此能够进一步地减小分析仪的体积。The sample rack 210 and the tip accommodating chamber 230 utilize the space occupied by the three-axis motion assembly 203 in the XY plane, so that the volume of the analyzer can be further reduced.
在一个实施例中,第一试剂臂310和第二试剂臂320分别与液路系统700相连。液路系统700还可以为所述试剂臂300提供洗液,其中,洗液是清水和酸洗液。In one embodiment, the first reagent arm 310 and the second reagent arm 320 are respectively connected to the fluid circuit system 700 . The liquid circuit system 700 can also provide washing liquid for the reagent arm 300, wherein the washing liquid is clean water and acid washing liquid.
液路系统还与清洗槽相连。清洗槽包括用于清洗第一试剂臂310中的试剂针的第一洗针池和用于清洗第二试剂臂320中的试剂针的第二洗针池。The hydraulic system is also connected to the cleaning tank. The cleaning tank includes a first needle washing tank for cleaning the reagent needles in the first reagent arm 310 and a second needle washing tank for cleaning the reagent needles in the second reagent arm 320 .
在本发明的一个实施例中,分析仪还包括控制系统800,控制系统800设置在下文所示的机架130的左侧。控制系统800分别与样本架210、急诊样本架220、反应杯加载模块400、移样臂模块200、吸头容纳仓230、承载模块100、试剂盘模块500、第一试剂臂310、第二试剂臂320、弃杯模块900、液路系统700以及光检测模块600电连接且通信连接,用于控制各模块之间配合执行相应的操作。In one embodiment of the present invention, the analyzer further includes a control system 800, and the control system 800 is disposed on the left side of the rack 130 shown below. The control system 800 is respectively connected with the sample rack 210 , the emergency sample rack 220 , the cuvette loading module 400 , the sample transfer arm module 200 , the tip storage compartment 230 , the carrying module 100 , the reagent tray module 500 , the first reagent arm 310 , and the second reagent The arm 320 , the cup discarding module 900 , the liquid circuit system 700 and the light detection module 600 are electrically and communicatively connected, and are used to control the cooperation between the modules to perform corresponding operations.
进一步地,本发明的分析仪还包括机架130和设置在机架130外部的外壳140,承载模块100和操作单元均设置在机架130上,且承载模块100设置在机架130的中间部位处。Further, the analyzer of the present invention further includes a rack 130 and a casing 140 disposed outside the rack 130 , the carrying module 100 and the operating unit are both disposed on the rack 130 , and the carrying module 100 is disposed in the middle of the rack 130 place.
另外本发明的分析仪还包括输入和输出部件。输入和输出部件设置在外壳140上。在试剂盘模块500的右下方还设置有试剂盘按钮,以便于对试剂盘模块500进行操作。Additionally, the analyzer of the present invention also includes input and output components. Input and output components are provided on the housing 140 . A reagent disk button is also provided at the lower right of the reagent disk module 500 to facilitate the operation of the reagent disk module 500 .
实施例2Example 2
如图4所示,示出了本发明的分析仪第二种实施方式,其包括用于承载反应杯120的承载模块100以及设置在承载模块100一侧的试剂盘模块500,其中,承载模块100和试剂盘模块500的数量为均一个。As shown in FIG. 4 , a second embodiment of the analyzer of the present invention is shown, which includes a carrier module 100 for carrying the cuvette 120 and a reagent tray module 500 arranged on one side of the carrier module 100 , wherein the carrier module The number of 100 and the reagent disk module 500 is the same.
与上述实施例1所不同的是,本实施例中的反应杯加载模块400的用于存储反应杯的存储器设置在承载模块100的上方,且垂直于承载模块100与试剂盘模块的中心连线延伸。The difference from the above-mentioned Embodiment 1 is that the memory for storing the cuvette of the cuvette loading module 400 in this embodiment is arranged above the carrying module 100 and is perpendicular to the center line connecting the carrying module 100 and the reagent tray module. extend.
在试剂盘模块500的右下方还设置有试剂盘按钮501,以便于对试剂盘模块500进行操作。A reagent disk button 501 is also provided at the lower right of the reagent disk module 500 to facilitate the operation of the reagent disk module 500 .
如图4所示,机架130的左侧(或右侧)还设置有用于支撑计算机一体机或者输入和输出设备(未示出)的支架160。控制系统800也设置在机架130的左侧(或右侧)。As shown in FIG. 4 , the left side (or right side) of the rack 130 is further provided with a bracket 160 for supporting an all-in-one computer or an input and output device (not shown). The control system 800 is also provided on the left side (or right side) of the rack 130 .
需要说明的是,在本实施例中仅描述了与实施例1的不同之处,相同的部件以操作在此不再赘述。It should be noted that only the differences from Embodiment 1 are described in this embodiment, and the same components and operations will not be repeated here.
可以理解地,本实施例中其他并未详细描述的各部件的结构均可参照实施例1中相同的部件而毫无意义地获得,并且可与实施例1中的各部件相结合而不会造成技术障碍。It can be understood that the structures of other components that are not described in detail in this embodiment can be obtained meaninglessly by referring to the same components in Embodiment 1, and can be combined with the components in Embodiment 1 without cause technical obstacles.
虽然已经参考优选实施例对本发明进行了描述,但在不脱离本发明的范围的情况下,可以对其进行各种改进并且可以用等效物替换其中的部件。尤其是,只要不存在冲突,各个实施例中所提到的各项技术特征均可以任意方式组合起来。本发明并不局限于文中公开的特定实施例,而是包括落入权利要求的范围内的所有技术方案。While the present invention has been described with reference to the preferred embodiments, various modifications may be made and equivalents may be substituted for parts thereof without departing from the scope of the invention. In particular, as long as there is no conflict, each technical feature mentioned in each embodiment can be combined in any manner. The present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims (9)

  1. 一种用于免疫诊断分析的检测系统,其特征在于,包括用于承载反应杯的承载模块以及操作系统,所述操作系统包括在所述承载模块的周向上依次设置的反应杯加载模块、移样臂模块、光检测模块、反应杯移除模块和试剂臂;A detection system for immunodiagnostic analysis, characterized in that it includes a carrier module for carrying a reaction cup and an operating system, wherein the operating system includes a reaction cup loading module, a moving Sample arm module, light detection module, cuvette removal module and reagent arm;
    其中,所述反应杯加载模块、所述移样臂模块、所述试剂臂、所述光检测模块和所述反应杯移除模块分别对所述承载模块中的反应杯进行相应的操作,从而在所述承载模块处完成化学反光反应。Wherein, the cuvette loading module, the sample transfer arm module, the reagent arm, the light detection module and the cuvette removal module respectively perform corresponding operations on the cuvette in the carrying module, thereby The chemical light reflection reaction is completed at the carrying module.
  2. 根据权利要求1所述的检测系统,其特征在于,所述承载模块的其中一侧设置有用于承载试剂的试剂盘模块,所述试剂臂设置在所述承载模块和所述试剂盘模块之间,从而将所述试剂盘模块中的试剂转移至所述承载模块中的反应杯中。The detection system according to claim 1, wherein a reagent tray module for carrying reagents is disposed on one side of the carrying module, and the reagent arm is disposed between the carrying module and the reagent tray module , so that the reagents in the reagent tray module are transferred to the reaction cups in the carrier module.
  3. 根据权利要求2所述的检测系统,其特征在于,还包括与所述移样臂模块的运动范围对应的资源站,所述资源站包括用于承载样本的样本架和用于承载加样针的容纳仓,所述样本架和所述容纳仓并列地设置在所述承载模块远离所述试剂盘的一侧,且所述容纳仓设置在所述样本架和所述承载模块之间。The detection system according to claim 2, further comprising a resource station corresponding to the movement range of the sample transfer arm module, the resource station comprising a sample holder for carrying samples and a sample holder for carrying a sample needle The accommodating compartment is arranged side by side on the side of the carrying module away from the reagent tray, and the accommodating compartment is arranged between the sample rack and the carrying module.
  4. 根据权利要求2或3所述的检测系统,其特征在于,所述反应杯加载模块包括用于存储反应杯的存储器,所述存储器的中心轴线平行于所述承载模块与所述试剂盘模块的中心连线。The detection system according to claim 2 or 3, wherein the cuvette loading module comprises a storage for storing the cuvette, and the central axis of the storage is parallel to the distance between the loading module and the reagent tray module. Center connection.
  5. 根据权利要求2或3所述的检测系统,其特征在于,所述反应杯加载模块包括用于存储反应杯的存储器,所述存储器的中心轴线垂直于所述承载模块与所述试剂盘模块的中心连线。The detection system according to claim 2 or 3, wherein the cuvette loading module comprises a storage for storing the cuvette, and the central axis of the storage is perpendicular to the distance between the loading module and the reagent tray module. Center connection.
  6. 根据权利要求3所述的检测系统,其特征在于,所述光检测模块和所述反应杯移除模块均设置在所述承载模块远离所述反应杯加载模块的一侧,且所述光检测模块靠近所述样本架,而所述反应杯移除模块靠近所述试剂盘模块。The detection system according to claim 3, wherein the light detection module and the cuvette removal module are both arranged on a side of the carrying module away from the cuvette loading module, and the light detection module The module is adjacent to the sample rack, and the cuvette removal module is adjacent to the reagent tray module.
  7. 根据权利要求6所述的检测系统,其特征在于,所述试剂臂的数量为两个,每个所述试剂臂转移所述试剂的路线均为弧线。The detection system according to claim 6, wherein the number of the reagent arms is two, and the route for transferring the reagent by each of the reagent arms is an arc.
  8. 根据权利要求7所述的检测系统,其特征在于,所述承载模块与所述试剂盘模块之间还设置有清洗槽,所述清洗槽用于清洗所述试剂臂中的试剂针,所述清洗槽设置在两个所述试剂臂的转移路线上。The detection system according to claim 7, wherein a cleaning tank is further provided between the carrying module and the reagent disk module, the cleaning tank is used for cleaning the reagent needles in the reagent arm, and the A wash tank is provided on the transfer path of both of the reagent arms.
  9. 根据权利要求8所述的检测系统,其特征在于,所述检测系统是用于化学发光分析仪的检测系统。The detection system of claim 8, wherein the detection system is a detection system for a chemiluminescence analyzer.
PCT/CN2021/113525 2020-08-20 2021-08-19 Detection system for immunodiagnostic analysis WO2022037646A1 (en)

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