CN214427284U - Analyzer for chemiluminescence detection - Google Patents

Analyzer for chemiluminescence detection Download PDF

Info

Publication number
CN214427284U
CN214427284U CN202022940461.0U CN202022940461U CN214427284U CN 214427284 U CN214427284 U CN 214427284U CN 202022940461 U CN202022940461 U CN 202022940461U CN 214427284 U CN214427284 U CN 214427284U
Authority
CN
China
Prior art keywords
reagent
analyzer
sample
carrier
dispensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202022940461.0U
Other languages
Chinese (zh)
Inventor
吴栋杨
练子富
李临
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemclin Diagnostics Corp
Original Assignee
Chemclin Diagnostics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemclin Diagnostics Corp filed Critical Chemclin Diagnostics Corp
Application granted granted Critical
Publication of CN214427284U publication Critical patent/CN214427284U/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system

Abstract

The utility model provides an analysis appearance for chemiluminescence detects, the analysis appearance includes the bearing mechanism of discoid rotation type, and around reaction vessel distributor mechanism, sample distributor mechanism, reagent distributor mechanism, light detection mechanism and the reaction vessel removal mechanism that bearing mechanism set up, bearing mechanism and the part that reaction vessel distributor mechanism corresponds form reaction vessel distribution area, bearing mechanism and the part that sample distributor mechanism corresponds form sample distribution area, bearing mechanism and the part that reagent distributor mechanism corresponds form reagent distribution area, bearing mechanism and the part that light detection mechanism corresponds form luminous detection area, bearing mechanism and the part that reaction vessel removal mechanism corresponds form reaction vessel removal area, bearing mechanism is constructed with a plurality of positions that hold that are used for loading reaction vessel, the plurality of accommodating positions are arranged on the bearing mechanism at equal intervals along the circumferential direction.

Description

Analyzer for chemiluminescence detection
Technical Field
The utility model relates to a chemiluminescence detects technical field, especially relates to an analysis appearance for chemiluminescence detects.
Background
The light-activated chemiluminescence detection is a homogeneous immunoassay technology, and is beneficial to quickly and fully completing immunoreaction.
Currently, such detection is generally performed using a fully automatic light-activated chemiluminescent detection device. The full-automatic detection device has the advantages that the working process of the detection device does not need human intervention or external intervention, and the accuracy and the high efficiency of the detection process are favorably ensured.
Existing detection devices for fully automated light-activated chemiluminescence detection are designed specifically for large hospitals or medical facilities for detecting as many samples as possible (e.g., at least about 100) simultaneously in the detection device. However, this usually requires the detection device to be provided with a plurality of (at least 2) incubation trays, which are typically arranged on the table top, distributed over each other. Although this apparatus can handle a very large number of samples simultaneously, each sample is subjected to a very large number of rotational movements on 2 incubation plates and requires transfer between 2 incubation plates. This makes the processing time for each sample relatively long. In addition, the detector has many structural components, so that the detector is relatively complex to fit with each other and is easy to make mistakes. Thus, such meters are only suitable for use in large hospitals where large numbers of samples are required to be processed densely, whereas for small hospitals or other small medical facilities, the efficiency is less if relatively few samples (e.g. less than 50) are to be processed.
There are also solutions in the prior art where multiple reagent disks or incubation disks are arranged coaxially. However, in this solution, the outermost disks would have a very large diameter. This results in a relatively poor stability of its operation, for example, prone to inaccurate positioning. In this case, many structural components are more prone to scheduling problems when fully automated mating is performed.
SUMMERY OF THE UTILITY MODEL
The utility model provides an analysis appearance for chemiluminescence detects can solve or alleviate at least one problem among the above-mentioned prior art through this kind of analysis appearance at least.
According to the present invention, an analyzer for chemiluminescence detection comprises a disk-shaped rotary carrier, and a reaction container distribution mechanism, a sample distribution mechanism, a reagent distribution mechanism, a light detection mechanism and a reaction container removal mechanism, which are disposed around the carrier, wherein the carrier and the reaction container distribution mechanism form a reaction container distribution area, the carrier and the sample distribution mechanism form a sample distribution area, the carrier and the reagent distribution mechanism form a reagent distribution area, the carrier and the light detection mechanism form a light-emitting detection area, the carrier and the reaction container removal mechanism form a reaction container removal area, and the carrier is configured with a plurality of receiving positions for loading a reaction container, the plurality of accommodating positions are arranged on the bearing mechanism at equal intervals along the circumferential direction; the analyzer further comprises a reagent disk, a reagent disk shell covers the upper portion of the reagent disk, the reagent disk shell comprises a sliding door capable of being opened in a sliding mode, a rotating handle is arranged on the sliding door, and the sliding door can be made to slide and open in a rotating mode relative to the reagent disk shell by rotating the rotating handle so as to expose the reagent disk.
Through the utility model discloses an above-mentioned analysis appearance, in whole testing process, reaction vessel all is located a and bears the weight of the mechanism. The detection process is advanced by rotating the reaction vessel to a different position by the carrier mechanism. Alternatively, the reaction vessels on the carrier may be moved to different receiving positions by a mechanical gripper for different detection steps. Because the whole detection process can be carried out on one bearing mechanism, the structure of the analyzer can be effectively simplified, and the volume and the weight of the whole analyzer are allowed to be greatly reduced. In addition, the matching between the structural components can be simpler, and errors and mistakes in control are not easy to occur. Such an analyzer is well suited for fully automated chemiluminescent detection in small hospitals or small medical facilities where demand is low. The arrangement of the sliding door and the rotating handle allows a user to access the reagent tray and dispense reagents to be used into the reagent tray.
In one embodiment, the reaction container distribution area, the sample distribution area, the luminescence detection area and the reaction container removal area are sequentially arranged around the bearing mechanism and are separated from each other by a preset distance.
In one embodiment, the reagent distribution region is concentric with the carrier means.
In one embodiment, the reaction container distribution area, the sample distribution area, the luminescence detection area, the reaction container removal area, and the reagent distribution area are sequentially disposed around the carrier mechanism and spaced apart from each other by a predetermined distance.
In one embodiment, the sample dispensing mechanism is disposed on one side of the carrier mechanism and comprises a dispenser and a mobile carriage for moving the dispenser, the mobile carriage comprising a movable cantilever arm extending in a direction of a long side of the analyzer. The projection of the range of motion of the cantilever on the analyzer intersects the contour of the carrier with at least one sample position.
In one embodiment, the analyzer further comprises a sample rack located on the same side of the carrier as the sample dispensing mechanism and within a range of movement of the cantilever of the mobile rack within a range of projection on the analyzer.
In one embodiment, the sample holder is in communication with ambient air of the analyzer.
In one embodiment, the analyzer further comprises a tip rack for holding tips, the tip rack being within a projection range of a movement range of the cantilever of the moving rack on the analyzer.
In one embodiment, the analyzer further comprises a reagent tray disposed adjacent to and spaced apart from the carrier mechanism, the reagent tray being located on the other side of the carrier mechanism opposite the sample distribution region, the reagent dispensing mechanism being disposed between the carrier mechanism and the reagent tray.
In one embodiment, the analyser further comprises a reagent tray arranged concentrically with the carrier, the reagent tray being located inside the carrier, the reagent dispensing mechanism being arranged between the carrier and the reagent tray.
In one embodiment, the reagent dispensing mechanism comprises a first reagent dispensing mechanism and a second reagent dispensing mechanism, the first and second reagent dispensing mechanisms being located on either side of a central line connecting the carrier mechanism and the reagent tray, respectively.
In one embodiment, a first reagent dispensing site is formed in the region where the reagent dispensing path of the first reagent dispensing mechanism overlaps the carrier mechanism and a plurality of first reagent access sites are formed in the region where the reagent dispensing path of the first reagent dispensing mechanism overlaps the reagent tray.
In one embodiment, a plurality of second reagent dispensing sites are formed in the region where the reagent dispensing paths of the second reagent dispensing mechanism overlap the carrier mechanism and at least one second reagent access site is formed in the region where the reagent dispensing paths of the second reagent dispensing mechanism overlap the reagent tray.
In one embodiment, the analyzer further includes a flow path block disposed behind the reagent dispensing mechanism in a short side direction of the analyzer, the flow path block including a washing mechanism for washing the reagent dispensing mechanism, the washing mechanism communicating with a reagent dispensing path of the reagent dispensing mechanism.
In one embodiment, the reaction container dispensing mechanism is disposed between the sample dispensing mechanism and the flow path block in a longitudinal direction of the analyzer, and the reaction container storage portion of the reaction container dispensing mechanism is disposed in parallel with the longitudinal direction of the analyzer.
In one embodiment, the reaction container dispensing mechanism is disposed between the sample dispensing mechanism and the flow path block in a long side direction of the analyzer, and the reaction container storage portion of the reaction container dispensing mechanism is disposed in parallel with a short side direction of the analyzer.
Drawings
The invention is described in more detail hereinafter with reference to the accompanying drawings, in which:
FIG. 1 shows a schematic top view of one embodiment of an analyzer for chemiluminescence detection according to the present invention, including a load bearing mechanism;
fig. 2 shows a schematic top view of another embodiment of an analyzer for chemiluminescence detection according to the invention, comprising a carrying mechanism.
In the drawings, like parts are provided with like reference numerals. The figures are not drawn to scale.
Detailed Description
The present invention will be further explained with reference to the accompanying drawings.
Fig. 1 and 2 schematically show a chemiluminescence analyzer (hereinafter referred to as "analyzer") 1 according to the present invention, which is particularly useful for fully automatic photoexcited chemiluminescence detection.
As shown in fig. 1 and 2, analyzer 1 includes a frame 160 for supporting other structural components of analyzer 1. A rotatable support 70 is arranged on the machine frame 160, which support 70 can be configured, for example, in the form of a disk, so that it can rotate about its own center. The analyzer 1 may further include a sample dispensing mechanism 20, a reaction vessel dispensing mechanism 60, a reagent tray (e.g., one reagent tray 110) for holding a reagent to be used, at least one reagent dispensing mechanism (e.g., two reagent dispensing mechanisms 80 and 120), a light detecting mechanism 150, and a reaction vessel removing mechanism 140, which are located on the rack 160 and are disposed around the one carrier mechanism 70. By providing these structural parts to surround the support means 70, corresponding regions can be formed in different parts of the support means 70. For example, the portion of the carrier mechanism 70 corresponding to the reaction vessel dispensing mechanism 60 forms a reaction vessel dispensing region a 1. The portion of the carrier mechanism 70 corresponding to the sample dispensing mechanism 20 (and reagent tray 110) forms a sample dispensing zone a 2. The portions of the carrier mechanism 70 corresponding to the reagent dispensing mechanisms 80, 120 form a reagent dispensing zone a 3. The portion of the support mechanism 70 corresponding to the light detection mechanism 150 forms a light emission detection area a 4. The portion of the carrier mechanism 70 corresponding to the reaction vessel removal mechanism 140 forms a reaction vessel removal area a 5.
It should be understood that the various regions described above do not change with the rotation of the carrier 70.
It should also be understood that the carrier mechanism 70 may be configured as a robotic arm or the like, and may be operated in any suitable manner, including translation or a combination of translation and rotation, to deliver reaction vessels into the respective zones.
The sample dispensing mechanism 20 includes a dispenser 23 for sucking a liquid, and a first axially movable support 21 and a second axially movable support 22 for moving the dispenser in a horizontal direction. By a first axial movement bracket 21 and a second axial movement bracket 22 extending perpendicularly to each other. It is obviously possible to provide that the first axially mobile carriage 21 is a cantilever movable along the second axially mobile carriage 22, and that the distributor 23 is mounted at the end of the movable cantilever. Alternatively, the boom movable along the first axial direction moving the support 21 while moving the support 22 in the second axial direction, and the distributor 23 is installed at the end of the movable boom. Thereby allowing the dispenser 23 to move horizontally relatively freely within a certain range. Within this range, sample racks for placing samples, such as the general sample rack 30 and the preferential sample rack 40 in fig. 1, may be provided. Within this range, a tip holder 50 for holding disposable tips may also be provided. The tip rack 50 may also include a tip disposal area 51. In addition, the above-described sample distribution area a2 is also within this movement range of the dispenser.
Here, the sample holder may be in communication with the environment outside the analyzer 1. In particular, the housing of the analyzer is provided with a void that mates with the sample holder, so that the sample holder is directly exposed to the ambient air. This facilitates on the one hand the reception of the sample from the outside and on the other hand also allows the sample on the sample holder to be kept at ambient temperature (typically room temperature) for more accurate detection.
In the above-described sample distribution region, a plurality of sample bits, for example, 2 sample bits, i.e., a first sample bit and a second sample bit, may be set. The sample position is the intersection point of the projection of the movement range of the cantilever on the analyzer and the contour of the bearing mechanism. For example, the carrier mechanism 70 may be rotated to the first reaction vessel at the first sample position to add the pre-sample (i.e., undiluted sample) from the sample rack to the first reaction vessel via the sample dispensing mechanism 20. Then, the carrier mechanism is rotated until the first reaction container is located in the reagent dispensing area a3, so as to add a reagent as a diluent into the first reaction container, and obtain a diluted sample in the first reaction container. Thereafter, the carrier mechanism 70 may be rotated again until the first reaction container is located at the second sample position, and the diluted sample in the first reaction container is added to another reaction container located at the first sample position as the sample to be detected by the sample dispensing mechanism 20. Thereby, a separate sample dilution device may be omitted.
It will be appreciated that, if desired, multiple dilutions between the first and second sample positions may be performed to obtain the sample to be tested.
It will also be appreciated that more sample sites may be provided to perform multiple dilution operations between each sample site to obtain a sample to be tested.
The priority sample rack may be used, for example, to place emergency samples. Here, the priority sample rack may be a sample rack designated by a user among a plurality of general sample racks. It is of course also conceivable to provide a separate preferential sample holder 40 which is closer to the carrier 70 than the generic sample holder 30. When the sample is placed on the priority sample rack 40, the analyzer 1 can automatically select to test the sample on the priority sample rack 40 first, and then test the sample on the general sample rack 30.
The pipette holder 50 is disposed between the sample holder and the carrier mechanism 70. The tip disposal area 51 is in turn provided on the side of the tip holder 50 adjacent to the carrier mechanism 70.
By the above arrangement, it is advantageous to simplify and optimize the moving path of the dispenser 23 in the sample dispensing mechanism 20.
In addition, the sample dispensing mechanism 20 may further include a mechanism operable to control the elevation and lowering of the dispenser 23 in the vertical direction to achieve engagement of the dispenser 23 with the sample rack, tip rack, and the portion of the carrier mechanism in the sample dispensing zone A2.
As shown in fig. 1 and 2, the above-described reaction container dispensing mechanism 60 includes a conveyor 63 adjacent to the reaction container dispensing area a1 of the carrying mechanism 70, a finisher 62 located above the conveyor 63, and a storage 61 connected to the finisher 62. The storage 61 is used for storing reaction vessels to be used. The collator 62 may receive reaction vessels from the store 61 (e.g., by an additional conveyor) and position the reaction vessels in a particular orientation. The conveyor 63 can receive the reaction vessels from the collator 62 and move them into the receiving positions 71 on the carrier 70. As shown in fig. 1, a plurality of receiving positions 71 may be provided on the carrier 70. These receiving locations 71 are arranged equidistantly spaced apart from each other in the circumferential direction.
In the embodiment shown in fig. 1, the memory 61 is located on the left side of the finisher 62 in the top view. The memory 61 extends in the longitudinal direction, or is disposed parallel to the longitudinal direction.
In the embodiment shown in fig. 2, the storage 61 is located on the lower side of the finisher 62 in plan view, overlying the carrier mechanism 70. The memory 61 extends in the short side direction, or is disposed parallel to the short side direction. This arrangement is more compact.
The reagent disk 110 is adjacent to but spaced from the reagent dispensing region a3 of the carrier mechanism 70. A first reagent dispensing mechanism 120 and a second reagent dispensing mechanism 80 are provided spaced apart from each other in the space above the chassis 160 between the reagent disk 110 and the carrier mechanism 70. The first and second reagent dispensing mechanisms 120, 80 are respectively mounted on either side of a line connecting the carrier mechanism 70 and the centre of the reagent disk 110. The first and second reagent dispensing mechanisms 120, 80 may, for example, be configured with reagent arms extending laterally from a mounting point, with a liftable reagent dispenser (not shown) mounted at the extended end of the reagent arms. The reagent arm may be rotated about the mounting, forming a reagent dispensing path P of the reagent dispenser as shown in figure 1.
In the preferred embodiment shown in fig. 1, the first reagent dispensing mechanism 120 is upstream in the direction of rotation of the carrier mechanism relative to the second reagent dispensing mechanism. That is, the first reagent dispensing mechanism 120 is on the lower side of the top view in fig. 1, and the second dispensing mechanism 80 is on the upper side of the top view in fig. 1. The first reagent dispensing mechanism 120 may be used, for example, to dispense a reagent that is specific to a single test item, referred to herein as a first reagent. The second reagent dispensing mechanism 80 may be used, for example, to dispense a reagent, referred to herein as a second reagent, that is required for each test item. It is noted herein that the foregoing first and second reagents are merely illustrative of the role of the first and second reagent dispensing mechanisms and should not be construed as limiting the use of the first and second reagents themselves. The first and second reagents may be configured according to the needs of the user.
Referring to fig. 2, a first reagent dispensing location L1 is formed in an area where the carrier mechanism 70 overlaps the reagent dispensing path of the first reagent dispensing mechanism 120. Accordingly, a first reagent catch site is formed in a region where the reagent disk 110 overlaps with the reagent dispensing path of the first reagent dispensing mechanism 120, for example, there are a plurality of first reagent catch sites L4 and L5. When the carrier mechanism 70 is rotated to the position where the first reaction container is located at the first reagent dispensing position L1, the first reagent dispensing mechanism 120 takes the corresponding first reagent from at least one of the first reagent taking positions L4 and L5, moves it to the first reagent dispensing position L1, and adds the first reagent to the first reaction container.
In addition, a second reagent dispensing site is formed in a region where the carrier mechanism 70 overlaps with the reagent dispensing path of the second reagent dispensing mechanism 80, and there are a plurality of second reagent dispensing sites L2 and L3, for example. Accordingly, the second reagent acquisition site L6 is formed in a region where the reagent disk 110 overlaps with the reagent dispensing path of the second reagent dispensing mechanism 80. When the carrier mechanism 70 is rotated to the first reaction container at one of the second reagent dispensing positions L2 and L3, the second reagent dispensing mechanism 80 takes the corresponding second reagent from the second reagent take position L6 and moves it to the corresponding first reagent dispensing position to add the second reagent to the first reaction container.
In a preferred embodiment, a cleaning mechanism 130 for cleaning the reagent dispensers is provided between the reagent disk 110 and the carrier mechanism 70. The washing mechanism 130 is preferably located on the reagent dispensing path P. This arrangement advantageously simplifies the working trajectory of the reagent dispensing mechanism 80, 120.
In the plan view shown in fig. 1, the reaction vessel distribution mechanism 60 and the reaction vessel distribution region a1 are located on the upper side of the carrier mechanism 70. The sample dispensing mechanism 20 is located on the left side of the carrier mechanism 70, and the sample dispensing region a2 is correspondingly formed on the left side, preferably the upper left side, of the carrier mechanism 70. The reagent disk 110 is formed to the right of the carrier mechanism 70 with the reagent dispensing mechanisms 80, 120 and the corresponding reagent dispensing zone a 3. The photodetection mechanism 150 and the corresponding luminescence detection zone a4, and the reaction vessel removal mechanism 140 and the reaction vessel removal zone a5 are formed on the lower side of the carrying mechanism 70, wherein the photodetection mechanism 150 and the corresponding luminescence detection zone a4 are closer to the sample distribution zone a2 (i.e., on the lower left side), and the reaction vessel removal mechanism 140 and the reaction vessel removal zone a5 are closer to the reagent distribution zone A3 (i.e., on the lower right side as viewed in fig. 1 or as viewed in fig. 2). For the arrangement shown in fig. 1 and 2, the lower side of the top view is the side of the analyzer that is closer to the user. The above arrangement may also be changed in mirror image in the up-down or left-right direction in plan view, as necessary.
In an alternative embodiment, the reagent disk 110 may also be arranged concentrically with the carrier 70 inside the carrier 70. Thus, the bearing mechanism 70 is formed substantially in a ring shape. The reagent dispensing mechanisms 80, 120 are disposed between the reagent disk 110 and the carrier mechanism 70. Thus, reagent dispensing region A3 is concentric with carrier mechanism 70.
As shown in fig. 2, the reagent disk 110 is covered above with a reagent disk housing including a slide door 111 slidably opened. The sliding door 111 is configured substantially in the shape of a sector, occupying 1/4 the entire reagent disk housing. A rotary handle 112 is provided on the sliding door 111. The rotating handle 112 extends outside the housing of the entire analyzer 1 so that the user can access the rotating handle 112. For example, a user may cause the sliding door 111 to rotationally slide relative to the entire reagent disk housing, and thereby open, by rotating the rotating handle 112. This allows a portion of the reagent disk 110 that is originally covered with the slide door 111 to be exposed. The user may place a reagent to be used into a corresponding receptacle in the reagent tray 110, or place a reagent receptacle containing a reagent to be used into a corresponding reagent site in the reagent tray 110.
As also shown in fig. 2, a button 113 is provided on the housing of the analyzer 1. The button 113 is configured to drive the reagent disk 110 to rotate when pressed by a user. Thus, when a user adds a reagent to the reagent disk 110 by opening the formed opening through the sliding door 111, the reagent disk 110 can be rotated by pressing the button 113, thereby exposing a different container or a different reagent site in the reagent disk 110 for the user to add the reagent.
In addition, as shown in fig. 1 and 2, a control module 10 is disposed at the upper left of the entire analyzer 1. The control module 10 can be used to control the operation of the various structural components of the analyzer 1 to implement the overall detection method (described in detail below). For example, the user may control the control module 10 (the central computer) by another computer (the upper computer) to implement the above working process. After the computer receives the information of the project to be tested, the corresponding work task is sent to the control module 10. The control module 10 schedules the various operating mechanisms (e.g., the reaction vessel dispensing mechanism 60, the sample dispensing mechanism 20, the reagent dispensing mechanisms 80 and 120, the light detection mechanism 150, the reaction vessel removing mechanism 140, etc.) according to the items to be measured. In addition, after the computer receives the information on the item to be measured, the computer also transmits the required reagent information to the control module 10. The control module 10 performs calculation according to the received reagent information to obtain the time required for the reagent kit containing the corresponding reagent in the reagent tray 110 to be pushed to the corresponding reagent acquisition position. The control module 10 drives the corresponding motors of the reagent disk 110 to rotate according to the time, so that the reagent cartridges on the reagent disk 110 and the corresponding reaction containers on the carrying mechanism 70 are rotated to the corresponding positions at the preset time to add the reagents. The computer and control module 10 described above is included in the control system of the chemiluminescence analyzer 1.
The computer and control module 10 is provided with a storage medium for storing a computer program for executing the method of operation of the analyzer 1 and the carrier 70.
Alternatively, the user may directly operate the control module 10 to perform the above-mentioned operation.
In addition, as shown in fig. 1 and 2, a flow path block 90 is arranged at the upper right of the entire analyzer 1. The flow path module 90 may be used, for example, to supply a washing fluid to the washing mechanism 130 and discharge waste liquid in the washing mechanism 130, thereby ensuring the accuracy of detection.
In the embodiment shown in fig. 1 and 2, the sample dispensing mechanism 20 is disposed on one side of the carrier mechanism 70 along the long side direction of the analyzer 1, and the reagent dispensing mechanisms 80 and 120 and the reagent disk 110 are disposed on the other side of the carrier mechanism 70 along the long side direction of the analyzer 1. The flow path block 90 is disposed behind the reagent dispensing mechanisms 80 and 120 in the short side direction (or above the reagent dispensing mechanisms 80 and 120 in a plan view). Further, the reaction well dispensing mechanism 60 is provided between the sample dispensing mechanism 20 and the flow path block 90 in the longitudinal direction of the analyzer 1.
Further, a case 100 is surrounded on all the structural components described above. A closed and light-tight environment is formed through the shell, so that efficient and high-accuracy detection is facilitated in the shell.
By means of the arrangement described above, an analyzer 1 can be realized which is as simple in construction as possible and as compact in layout as possible. Such an analyzer 1 can effectively reduce the size of the analyzer without reducing the size of the carrying mechanism. This volume can be reduced by at least 1/3 compared to prior art detection devices. Such an analyzer 1 can be used effectively in small hospitals and small medical facilities to improve the cost-effectiveness of the test.
In this context, the reaction vessel may be, for example, a test tube or a reaction cup or the like.
While the invention has been described with reference to a preferred embodiment, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In particular, the technical features mentioned in the embodiments can be combined in any way as long as there is no structural conflict. The present invention is not limited to the particular embodiments disclosed herein, but encompasses all technical solutions falling within the scope of the claims.

Claims (16)

1. An analyzer for chemiluminescence detection, which comprises a disc-shaped rotary bearing mechanism, and a reaction container distribution mechanism, a sample distribution mechanism, a reagent distribution mechanism, a light detection mechanism and a reaction container removal mechanism which are arranged around the bearing mechanism, wherein the part of the bearing mechanism corresponding to the reaction container distribution mechanism forms a reaction container distribution area, the part of the bearing mechanism corresponding to the sample distribution mechanism forms a sample distribution area, the part of the bearing mechanism corresponding to the reagent distribution mechanism forms a reagent distribution area, the part of the bearing mechanism corresponding to the light detection mechanism forms a luminescence detection area, and the part of the bearing mechanism corresponding to the reaction container removal mechanism forms a reaction container removal area,
the carrying mechanism is configured with a plurality of accommodating positions for loading reaction containers, and the accommodating positions are arranged on the carrying mechanism at equal intervals along the circumferential direction;
the analyzer further comprises a reagent disk, a reagent disk shell covers the upper portion of the reagent disk, the reagent disk shell comprises a sliding door capable of being opened in a sliding mode, a rotating handle is arranged on the sliding door, and the sliding door can be made to slide and open in a rotating mode relative to the reagent disk shell by rotating the rotating handle so as to expose the reagent disk.
2. The analyzer for chemiluminescence detection according to claim 1, wherein the reaction vessel distribution region, the sample distribution region, the luminescence detection region, and the reaction vessel removal region are sequentially disposed around the carrier mechanism and spaced apart from each other by a predetermined distance.
3. The analyzer for chemiluminescent detection of claim 2 wherein the reagent dispensing region is concentric with the carrier mechanism.
4. The analyzer for chemiluminescence detection according to claim 1, wherein the reaction container distribution region, the sample distribution region, the luminescence detection region, the reaction container removal region, and the reagent distribution region are sequentially disposed around the carrier mechanism and spaced apart from each other by a predetermined distance.
5. The analyzer for chemiluminescence detection according to claim 1, wherein the sample dispensing mechanism is disposed on one side of the carrier mechanism, and the sample dispensing mechanism comprises a dispenser and a movable support for moving the dispenser, the movable support comprising a movable cantilever extending in a long side direction of the analyzer, a projection of a range of movement of the cantilever onto the analyzer intersecting a contour of the carrier mechanism with at least one sample position.
6. The analyzer for chemiluminescence detection according to claim 5, further comprising a sample holder located on the same side of the carrier as the sample dispensing mechanism and within a projected range of movement of the cantilever of the mobile carriage on the analyzer.
7. The analyzer for chemiluminescence detection of claim 6, wherein the sample holder is in communication with ambient air of the analyzer.
8. The analyzer for chemiluminescence detection according to claim 5, further comprising a tip holder for holding a tip, the tip holder being within a range of projection of a range of movement of the cantilever of the moving support on the analyzer.
9. The analyzer for chemiluminescence detection according to any one of claims 1 to 8, wherein the analyzer further comprises a reagent disk disposed adjacent to and spaced apart from the carrier mechanism, the reagent disk being located on the other side of the carrier mechanism opposite to the sample distribution region, the reagent dispensing mechanism being disposed between the carrier mechanism and the reagent disk.
10. An analyser for chemiluminescent detection according to any one of claims 1 to 8 further comprises a reagent tray concentrically disposed with the carrier, the reagent tray being located inside the carrier, the reagent dispensing mechanism being disposed between the carrier and the reagent tray.
11. An analyser for chemiluminescent detection according to claim 9 wherein the reagent dispensing mechanism comprises a first reagent dispensing mechanism and a second reagent dispensing mechanism located on either side of a central line connecting the carrier mechanism and reagent tray respectively.
12. The analyzer for chemiluminescence detection according to claim 11, wherein a first reagent dispensing site is formed in a region where the reagent dispensing path of the first reagent dispensing mechanism overlaps the carrier mechanism, and a plurality of first reagent acquisition sites are formed in a region where the reagent dispensing path of the first reagent dispensing mechanism overlaps the reagent disk.
13. The analyzer for chemiluminescence detection according to claim 12, wherein a plurality of second reagent dispensing sites are formed in a region where the reagent dispensing path of the second reagent dispensing mechanism overlaps the carrier mechanism, and at least one second reagent capture site is formed in a region where the reagent dispensing path of the second reagent dispensing mechanism overlaps the reagent tray.
14. The analyzer for chemiluminescence detection according to claim 1, further comprising a flow path block disposed after the reagent dispensing mechanism in a short side direction of the analyzer, the flow path block comprising a washing mechanism for washing the reagent dispensing mechanism, the washing mechanism being in communication with a reagent dispensing path of the reagent dispensing mechanism.
15. The analyzer for chemiluminescence detection according to claim 14, wherein the reaction vessel dispensing mechanism is provided between the sample dispensing mechanism and the flow path block in a longitudinal direction of the analyzer, and a reaction vessel storage portion of the reaction vessel dispensing mechanism is provided in parallel with the longitudinal direction of the analyzer.
16. The analyzer for chemiluminescence detection according to claim 14, wherein the reaction vessel dispensing mechanism is provided between the sample dispensing mechanism and the flow path block in a longitudinal direction of the analyzer, and a reaction vessel storage portion of the reaction vessel dispensing mechanism is provided in parallel with a short-side direction of the analyzer.
CN202022940461.0U 2020-08-20 2020-12-10 Analyzer for chemiluminescence detection Active CN214427284U (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010842969 2020-08-20
CN2020108429699 2020-08-20

Publications (1)

Publication Number Publication Date
CN214427284U true CN214427284U (en) 2021-10-19

Family

ID=78050842

Family Applications (6)

Application Number Title Priority Date Filing Date
CN202011436004.6A Pending CN114076757A (en) 2020-08-20 2020-12-10 Analyzer for chemiluminescence detection
CN202022933877.XU Active CN215263138U (en) 2020-08-20 2020-12-10 Analyzer for chemiluminescence detection
CN202011435987.1A Pending CN114076756A (en) 2020-08-20 2020-12-10 Analyzer for chemiluminescence detection
CN202022940461.0U Active CN214427284U (en) 2020-08-20 2020-12-10 Analyzer for chemiluminescence detection
CN202023026184.9U Active CN215641286U (en) 2020-08-20 2020-12-15 Detection system for immunodiagnosis analysis
CN202011480106.8A Pending CN114076822A (en) 2020-08-20 2020-12-15 Detection system for immunodiagnosis analysis

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CN202011436004.6A Pending CN114076757A (en) 2020-08-20 2020-12-10 Analyzer for chemiluminescence detection
CN202022933877.XU Active CN215263138U (en) 2020-08-20 2020-12-10 Analyzer for chemiluminescence detection
CN202011435987.1A Pending CN114076756A (en) 2020-08-20 2020-12-10 Analyzer for chemiluminescence detection

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202023026184.9U Active CN215641286U (en) 2020-08-20 2020-12-15 Detection system for immunodiagnosis analysis
CN202011480106.8A Pending CN114076822A (en) 2020-08-20 2020-12-15 Detection system for immunodiagnosis analysis

Country Status (2)

Country Link
CN (6) CN114076757A (en)
WO (1) WO2022037646A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022037646A1 (en) * 2020-08-20 2022-02-24 科美诊断技术股份有限公司 Detection system for immunodiagnostic analysis

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116297416B (en) * 2023-05-22 2023-11-10 科美诊断技术股份有限公司 Photo-excitation chemiluminescence detection device and detection method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0560765A (en) * 1991-09-04 1993-03-12 Kyowa Medetsukusu Kk Automatic analyzer
JPH10311837A (en) * 1997-05-13 1998-11-24 Horiba Ltd Chemiluminescence enzyme immunoassay device
CN110133314B (en) * 2018-02-08 2021-12-24 成都深迈瑞医疗电子技术研究院有限公司 Full-automatic chemiluminescence immunoassay analyzer
CN108593949B (en) * 2018-02-11 2024-01-26 金博特(北京)生物科技有限公司 Chemiluminescence immunity analyzer
CN109030809B (en) * 2018-10-31 2021-08-20 蓝怡科技集团股份有限公司 Allergen IgE antibody automatic analyzer
CN110412306A (en) * 2018-12-11 2019-11-05 宁波医杰生物科技有限公司 A kind of full-automatic detector
CN210090481U (en) * 2019-05-31 2020-02-18 艾特生物科技(深圳)有限公司 Chemiluminescence immunoassay appearance
CN114076757A (en) * 2020-08-20 2022-02-22 科美诊断技术股份有限公司 Analyzer for chemiluminescence detection

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022037646A1 (en) * 2020-08-20 2022-02-24 科美诊断技术股份有限公司 Detection system for immunodiagnostic analysis

Also Published As

Publication number Publication date
CN114076757A (en) 2022-02-22
CN114076822A (en) 2022-02-22
WO2022037646A1 (en) 2022-02-24
CN215641286U (en) 2022-01-25
CN114076756A (en) 2022-02-22
CN215263138U (en) 2021-12-21

Similar Documents

Publication Publication Date Title
JP4232982B2 (en) Sample automatic clinical analyzer
JP4243722B2 (en) How to perform verification with a multistage analyzer system
JP4033060B2 (en) Automatic analyzer
US10197585B2 (en) Automated diagnostic analyzers having vertically arranged carousels and related methods
CN214427284U (en) Analyzer for chemiluminescence detection
US4224032A (en) Method and apparatus for chemical analysis
US8048374B2 (en) Automatic analyzer
US8257650B2 (en) Automated analyzer
JP3830836B2 (en) Automatic analyzer
JP2004279357A (en) Autoanalyzer
WO2011037069A1 (en) Automatic analyzing device, information display method thereof, and information display system
US8066943B2 (en) Clinical analyzer having a variable cycle time and throughput
US20080020467A1 (en) Fluid metering in a metering zone
CN1534298B (en) Analysis instrument having fixed multifunction probe
US20050123444A1 (en) Analyzer having removable holders or a centrifuge
JPH01187461A (en) Automatic chemical analyzer
KR20040097953A (en) Analyzer having concentric rotors
JP3068253B2 (en) Automatic analyzer
WO2022037629A1 (en) Operating method for chemiluminescence analyzer
JP3377299B2 (en) Automatic blood analyzer
JP2014085150A (en) Automatic analyzer
CN113711054A (en) Automatic analyzer and method for designing automatic analyzer
JP3278523B2 (en) Automatic chemical analyzer
JPS5951359A (en) Reagent feeder for automatic biochemical analyzer
JPH0421140B2 (en)

Legal Events

Date Code Title Description
GR01 Patent grant
GR01 Patent grant