WO2022027746A1 - 降低药液损耗的灌装方法 - Google Patents

降低药液损耗的灌装方法 Download PDF

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Publication number
WO2022027746A1
WO2022027746A1 PCT/CN2020/111388 CN2020111388W WO2022027746A1 WO 2022027746 A1 WO2022027746 A1 WO 2022027746A1 CN 2020111388 W CN2020111388 W CN 2020111388W WO 2022027746 A1 WO2022027746 A1 WO 2022027746A1
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WO
WIPO (PCT)
Prior art keywords
filling
liquid
medicine
needle
medicinal
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PCT/CN2020/111388
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English (en)
French (fr)
Inventor
钱瞻
彭伟
易波
柏天桥
龙煌辉
Original Assignee
楚天科技股份有限公司
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Application filed by 楚天科技股份有限公司 filed Critical 楚天科技股份有限公司
Priority to EP20948362.7A priority Critical patent/EP4180341A4/en
Priority to KR1020237006853A priority patent/KR20230041812A/ko
Priority to US18/019,815 priority patent/US20230286682A1/en
Publication of WO2022027746A1 publication Critical patent/WO2022027746A1/zh

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/02—Machines characterised by the incorporation of means for making the containers or receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B65B3/10—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material
    • B65B3/12—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material mechanically, e.g. by pistons or pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/24—Topping-up containers or receptacles to ensure complete filling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/26—Methods or devices for controlling the quantity of the material fed or filled
    • B65B3/28—Methods or devices for controlling the quantity of the material fed or filled by weighing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B39/00—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers
    • B65B39/12—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers movable towards or away from container or wrapper during filling or depositing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices
    • B65B57/10—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged
    • B65B57/14—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged and operating to control, or stop, the feed of articles or material to be packaged
    • B65B57/145—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged and operating to control, or stop, the feed of articles or material to be packaged for fluent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B65/00—Details peculiar to packaging machines and not otherwise provided for; Arrangements of such details
    • B65B65/003—Packaging lines, e.g. general layout
    • B65B65/006—Multiple parallel packaging lines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
    • B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
    • B67C3/22—Details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
    • B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
    • B67C3/22—Details
    • B67C3/26—Filling-heads; Means for engaging filling-heads with bottle necks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01G—WEIGHING
    • G01G15/00—Arrangements for check-weighing of materials dispensed into removable containers
    • G01G15/04—Arrangements for check-weighing of materials dispensed into removable containers with provision for adding or removing a make-up quantity of material to obtain the desired gross weight
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01G—WEIGHING
    • G01G17/00—Apparatus for or methods of weighing material of special form or property
    • G01G17/04—Apparatus for or methods of weighing material of special form or property for weighing fluids, e.g. gases, pastes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B2210/00—Specific aspects of the packaging machine
    • B65B2210/06—Sterilising or cleaning machinery or conduits
    • B65B2210/08—Cleaning nozzles, funnels or guides through which articles are introduced into containers or wrappers

Definitions

  • the invention relates to the technical field of food and medicine packaging machinery and equipment, in particular to a filling method for reducing the loss of medicinal liquid.
  • the existing liquid medicine filling device includes a filling needle, a filling station, a pre-weighing station located in front of the filling station for weighing empty bottles, and a pre-weighing station located after the filling station for weighing the filled liquid.
  • the filling needle is fixed above the filling station, so that a liquid replenishing mechanism must be set up on the subsequent station of the filling station to replenish the bottle body that has not been filled with liquid up to the standard.
  • the manufacturing cost of the liquid medicine filling device is increased, and there are many stations, so that the work efficiency is low.
  • the existing fluid replenishment mechanism has low fluid replenishment efficiency, and it is difficult to fill the high-efficiency fluid replenishment requirements.
  • the general residual amount ranges from 500ml to 2000ml. If the residual liquid medicine is used well, according to the volume of medicine bottles of 2ml specification, one batch can produce more than 500-1000 bottles of qualified products. According to the market value of 100 yuan per bottle, one batch can produce more than one batch of qualified products. Products with a market value of 50,000-100,000 can be calculated in 100 batches a year, and more products with a market value of 5-10 million can be produced. For high value-added biological drugs and innovative drugs, the economic benefits generated are huge.
  • the technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a filling method that can reduce the loss of medicinal liquid.
  • the present invention adopts the following technical solutions:
  • a filling method for reducing the loss of medicinal liquid comprising a plurality of weighing stations and a liquid separation container, the liquid separation container is provided with a plurality of liquid outlets, and a plurality of side-by-side arrangements are correspondingly arranged above the plurality of weighing stations
  • Each of the liquid outlets is connected to each of the filling needles through pipes, and each of the pipes is provided with a filling pump to fill the remaining medicinal liquid in the pipeline.
  • the filling method includes: a medicine bottle It is transported to the weighing station, the first filling needle is used to fill the medicine bottle, and then the adjacent second filling needle is used for replenishment filling or the third filling needle is used for replenishment filling until the medicine bottle is filled with liquid medicine. If the quantity is qualified, the medicine bottles are filled one by one and the remaining medicine liquid in the pipeline is emptied.
  • the first filling needle is a filling needle
  • the second filling needle is a filling needle adjacent to the filling needle
  • the third filling needle is a filling needle that is not adjacent to the filling.
  • the filling method also includes quantitatively filling the medicine bottles at the weighing station, and replenishing liquid while weighing, so that the amount of medicine in each medicine bottle reaches the standard.
  • the filling method further comprises: weighing on a weighing station, and filling the bottles synchronously, and filling medicine liquid with a low-position filling needle for medicine bottles whose filling quantity does not meet the standard.
  • the lowest filling needle is used to fill the medicine liquid.
  • the liquid-separating container is arranged obliquely, and among the adjacent filling needles, the rear filling needle is connected with the high-level liquid outlet on the liquid-separating container, and the front filling needle is connected with the low-position liquid outlet on the liquid-separating container.
  • the inclination angle of the liquid separation container is a, 0° ⁇ a ⁇ 10°.
  • the liquid medicine filling device also includes a medicine supply device, a liquid inlet valve and a buffer tank.
  • the medicine supply device and the buffer tank are connected by a liquid inlet pipeline, and a liquid inlet valve is arranged on the liquid inlet pipeline.
  • the tank and the liquid separation container are connected by connecting pipes.
  • the top of the liquid separation container is provided with a liquid inlet, and the buffer tank is connected with the liquid inlet of the liquid separation container through a connecting pipeline.
  • the filling method for reducing the loss of medicinal liquid of the present invention includes a plurality of weighing stations and a liquid separation container, the liquid separation container is provided with a plurality of liquid outlets, and a plurality of filling needles arranged side by side are correspondingly arranged above the plurality of weighing stations , each liquid outlet and each filling needle are respectively connected by pipes, and each pipe is provided with a filling pump to fill the remaining liquid medicine in the pipeline.
  • the filling method includes: detecting that the amount of liquid medicine in the liquid separation container is insufficient, The medicine bottle is transported to the weighing station, and the first filling needle fills the medicine bottle, and then the adjacent second filling needle carries out liquid filling filling or the third filling needle carries out liquid filling filling until the medicine bottle is filled with liquid.
  • the filling volume is qualified, so that the medicine bottles are filled one by one and the remaining medicine liquid in the pipeline is emptied.
  • the filling method can fill and empty the remaining medicinal liquid in each pipeline one by one, thereby reducing the loss of medicinal liquid.
  • FIG. 1 is a schematic structural diagram of the liquid medicine filling device of the present invention.
  • FIG. 2 is a comparison diagram of the liquid medicine filling method of the present invention when the tail liquid is filled.
  • FIG. 3 is a schematic structural diagram of the liquid dispensing container of the liquid medicine filling device of the present invention.
  • the liquid dispensing container 4 is provided with a plurality of liquid outlets 41, and a plurality of filling needles 5 arranged side by side are correspondingly arranged above the plurality of weighing stations 1.
  • Each liquid outlet 41 and each filling needle 5 are respectively connected through pipes 6.
  • 6 is provided with a filling pump 61, and the filling method includes: filling the remaining medicinal liquid in the pipeline 6, and the specific method is as follows: the medicine bottle is transported to the weighing station 1, and the medicine bottle is carried out by the first filling needle 5.
  • the filling method can fill and empty the remaining medicinal liquid in each pipeline 6 one by one, thereby reducing the loss of medicinal liquid.
  • the first filling needle 5 is one filling needle 5
  • the second filling needle 5 is the filling needle 5 adjacent to the filled filling needle 5
  • the third filling needle 5 is the filling needle 5 that has been filled and not adjacent.
  • the medicine bottle is filled by one filling needle 5
  • the filling needle 5 adjacent to the filled medicine bottle is filled with liquid; alternatively, the medicine bottle is filled by one filling needle 5, Filling the non-adjacent filling needles 5 for liquid filling; if the filling is still not qualified, continue to use the other filling needles 5 that are not filled to carry out liquid filling; Fill the medicine bottles one by one to empty the remaining medicine liquid in the pipeline 6 .
  • the filling method further includes quantitatively filling the medicine bottles at the weighing station 1, and replenishing liquid while weighing, so that the amount of medicine in each medicine bottle reaches the standard.
  • each filling needle 5 can be used for both quantitative filling and supplementary filling, which improves the efficiency of fluid supplementation; for another example, normal filling is performed on weighing station 1. Production, filling and refilling are all carried out on weighing station 1, which improves production efficiency.
  • the filling method further includes: weighing on the weighing station 1, and filling synchronously, and filling the medicine bottle with the low-position filling needle 5 for filling the medicine bottle whose filling quantity does not meet the standard.
  • Synchronous filling means that all filling needles 5 are filled at the same time, and the filling is performed while filling. For example, when the tail liquid in the liquid dispensing container 4 is filled, each filling needle 5 is first filled synchronously, and then the low-level filling needle 5 is used to fill the medicine bottle that does not meet the standard, which improves the efficiency of tail liquid filling and also This reduces the waste of medicinal solution.
  • the medicine liquid is supplemented by the filling needle 5 at the lowest position for the medicine bottle whose filling amount is not up to the standard.
  • the lowest filling needle 5 is used for liquid replenishment, and other filling needles 5 are filled normally until no medicinal liquid flows out.
  • the number of movements of the medicine bottle is increased, the operation is simpler, and the work efficiency is improved.
  • the liquid dispensing container 4 is arranged obliquely.
  • the rear filling needle 5 is connected to the liquid outlet 41 at the upper position of the liquid separation container 4, and the front filling needle 5 is connected to the upper low position of the liquid separation container 4.
  • the liquid outlet 41 is connected.
  • the inclination angle of the liquid separation container 4 is a, 0° ⁇ a ⁇ 10°.
  • the liquid medicine filling device also includes a medicine supply device 7, a liquid inlet valve 8 and a buffer tank 9.
  • the medicine supply device 7 and the buffer tank 9 are connected by a liquid inlet pipeline.
  • the liquid inlet pipeline is provided with a liquid inlet valve 8 and a buffer tank 9. It is connected to the liquid separation container 4 through a connecting line.
  • the top of the liquid separation container 4 is provided with a liquid inlet 42, and the buffer tank 9 is connected with the liquid inlet 42 of the liquid separation container 4 through a connecting pipeline.
  • the specific filling steps of the liquid medicine filling device are as follows:
  • the first step Filling and emptying (take the number of filling needles 5 as 8 and the number of scales at weighing station 1 as 8 as an example, each filling needle 5 is labeled A1-A8 from front to back along the conveying direction F of the bottle , each scale is labeled B1-B8 from front to back, each filling needle 5 is aligned with each scale on weighing station 1)
  • the buffer tank 9 is intermittently supplied with liquid into the liquid separation container 4 to realize bubble-free filling in the liquid separation container 4;
  • each filling needle 5 is inserted into the bottle mouth (the whole group of 8 medicine bottles are labeled C1-C8 bottles from front to back);
  • the third step is. Tail liquid filling (the first method)
  • step c If it is qualified, the single-bottle filling will end, and the bottle will continue to be filled with the next bottle; if it is unqualified, jump to step c to continue filling, and the target filling amount at this time is the deviation value calculated last time;
  • the air in the pipeline is drained.
  • the filling volume of the medicine bottle does not meet the standard. cause waste of medicines.
  • the high-level filling needle 5 will be filled quantitatively first, and the low-level filling needle 5 will be filled one by one, so as to effectively utilize the tail liquid (remaining liquid medicine) and ensure that at most one bottle of liquid medicine is filled. Failed.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Basic Packing Technique (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)

Abstract

一种降低药液损耗的灌装方法，包括多个称重工位（1）和分液容器（4），分液容器（4）设有多个出液口（41），多个称重工位（1）上方对应设有多个并排布置的灌针（5），各出液口（41）与各灌针（5）分别通过管道（6）连接，各管道（6）上均设有灌装泵（61）；灌装方法包括：检测到分液容器（4）内药液量不足，药瓶输送至称重工位（1）上，由第一灌针（5）对药瓶进行灌装，再由相邻的第二灌针（5）进行补液灌装或再由第三灌针（5）进行补液灌装，直至药瓶药液灌装量合格，以此分别对药瓶进行逐一灌装，排空管道（6）内剩余药液。

Description

降低药液损耗的灌装方法 技术领域
本发明涉及食品、药品包装机械设备技术领域，尤其涉及一种降低药液损耗的灌装方法。
 背景技术
现有的药液灌装装置包括灌针、灌装工位、位于灌装工位前用于称重空瓶的前称重工位和位于灌装工位后用于称重灌有药液的总瓶的后称重工位，灌针固定设于灌装工位的上方，使得，在灌装工位的后续工位上必须设置补液机构，对未注液达标的瓶体进行补液，由此，增加了药液灌装装置的制造成本，且工位较多，以致工作效率低。而且，现有的补液机构，补液效率低，难以灌足高效的补液要求。并且，采用现有药液灌装装置灌装药液时，造成药液浪费量大。同时，药液灌装的装量需要严格控制，尤其在药品灌装的初始阶段，灌装装置的管道内有空气，灌装时很难精准定量灌装，对灌装后药瓶进行计量，如不符合装量标准就必须剔除，从而导致药品浪费。而且在一批次药液灌装工序末尾阶段，由于总的药液量不足，在对多个药瓶进行灌装药液时，很难保证药瓶内灌装的装量合格，对药液灌装量不合格的药瓶也必须剔除，再一次导致药品浪费。
灌装系统在生产准备阶段的排空、尾液灌装阶段，一般都采用人工干预的方式进行处理，效率低、污染的风险大、药液的残留多。根据不同的装量规格和灌装头数，一般的残留量在500ml-2000ml不等。如果把残留药液很好的利用起来，根据2ml规格的药瓶装量，一个批次可以多生产出500-1000瓶左右的合格品，按市场价值100元/支计算，一个批次可多生产出市值5-10万的产品，一年按100个批次计算，可多生产出市值500-1000万的产品。对于高附加值的生物药和创新药，那产生的经济效益巨大。
 技术问题
本发明要解决的技术问题是克服现有技术的不足，提供一种能够降低药液损耗的灌装方法。
 技术解决方案
为解决上述技术问题，本发明采用以下技术方案：
一种降低药液损耗的灌装方法，包括多个称重工位和分液容器，所述分液容器设有多个出液口，所述多个称重工位上方对应设有多个并排布置的灌针，各所述出液口与各灌针分别通过管道连接，各所述管道上均设有灌装泵，对管道内剩余药液的灌装，所述灌装方法包括：药瓶输送至称重工位上，由第一灌针对药瓶进行灌装，再由相邻的第二灌针进行补液灌装或再由第三灌针进行补液灌装，直至药瓶药液灌装量合格，以此分别对药瓶进行逐一灌装排空管道内剩余药液。
作为上述技术方案的进一步改进：
所述第一灌针为一个灌针，所述第二灌针为与已灌装相邻的灌针，所述第三灌针为已灌装不相邻的灌针。
所述灌装方法还包括在称重工位上对药瓶进行定量灌装，并边称重边补液，使各药瓶中的药量达标。
所述灌装方法还包括：在称重工位上进行称重，并同步灌装，对灌装量不达标的药瓶由低位灌针补灌药液。
对灌装量不达标的药瓶由最低位灌针补灌药液。
所述分液容器倾斜设置，相邻灌针中，后方的灌针与分液容器上高位的出液口连接，前方的灌针与分液容器上低位的出液口连接。
所述分液容器的倾斜角为ａ，0°＜ａ≤10°。
所述药液灌装装置还包括供药装置、进液阀和缓冲罐，所述供药装置和缓冲罐通过进液管路连接，所述进液管路上设有进液阀，所述缓冲罐与分液容器通过连接管路连接。
所述分液容器的顶部设有进液口，所述缓冲罐与分液容器的进液口通过连接管路连接。
 有益效果
与现有技术相比，本发明的优点在于：
本发明的降低药液损耗的灌装方法，包括多个称重工位和分液容器，分液容器设有多个出液口，多个称重工位上方对应设有多个并排布置的灌针，各出液口与各灌针分别通过管道连接，各管道上均设有灌装泵，对管道内剩余药液的灌装，灌装方法包括：检测到分液容器内药液量不足，药瓶输送至称重工位上，由第一灌针对药瓶进行灌装，再由相邻的第二灌针进行补液灌装或再由第三灌针进行补液灌装，直至药瓶药液灌装量合格，以此分别对药瓶进行逐一灌装排空管道内剩余药液。该灌装方法能够逐一灌装排空各管道内剩余的药液，从而降低药液损耗。
 附图说明
图1是本发明的药液灌装装置的结构示意图。
图2是本发明药液灌装方法在尾液灌装时的对比图。
图3是本发明的药液灌装装置的分液容器的结构示意图。
图中各标号表示：
1、称重工位；4、分液容器；41、出液口；42、进液口；5、灌针；6、管道；61、灌装泵；7、供药装置；8、进液阀；9、缓冲罐。
 本发明的实施方式
以下将结合说明书附图和具体实施例对本发明做进一步详细说明。
图1至图3示出了本发明降低药液损耗的灌装方法的一种实施例，采用药液灌装装置进行，药液灌装装置包括多个称重工位1和分液容器4，分液容器4设有多个出液口41，多个称重工位1上方对应设有多个并排布置的灌针5，各出液口41与各灌针5分别通过管道6连接，各管道6上均设有灌装泵61，灌装方法包括：对管道6内剩余药液的灌装，具体方法为：药瓶输送至称重工位1上，由第一灌针5对药瓶进行灌装，再由相邻的第二灌针5进行补液灌装或再由第三灌针5进行补液灌装，直至药瓶药液灌装量合格，以此分别对药瓶进行逐一灌装排空管道6内剩余药液。该灌装方法能够逐一灌装排空各管道6内剩余的药液，从而降低药液损耗。
本实施例中，第一灌针5为一个灌针5，第二灌针5为与已灌装相邻的灌针5，第三灌针5为已灌装不相邻的灌针5。具体为，由一个灌针5对药瓶进行灌装后，由与已灌装相邻的灌针5进行补液灌装；或者，由一个灌针5对药瓶进行灌装，再由与已灌装不相邻的灌针5进行补液灌装；如仍未灌装合格，则继续由未灌装的其它灌针5进行补液灌装；直至药瓶药液灌装量合格，以此分别对药瓶进行逐一灌装排空管道6内剩余药液。
本实施例中，灌装方法还包括在称重工位1上对药瓶进行定量灌装，并边称重边补液，使各药瓶中的药量达标。如，在称重工位1上进行尾液灌装，各灌针5均能用于定量灌装又能用于补灌，提高了补液效率；又如，在称重工位1上进行正常灌装生产，灌装和补灌均在称重工位1上进行，提高了生产效率。
本实施例中，灌装方法还包括：在称重工位1上进行称重，并同步灌装，对灌装量不达标的药瓶由低位灌针5补灌药液。同步灌装为，所有灌针5同时灌装，并进行边灌边称。如分液容器4内的尾液灌装时，各灌针5先同步灌装，然后，再通过低位灌针5对未达标的药瓶进行补灌，提高了尾液灌装的效率，也该减少了药液浪费量。
本实施例中，对灌装量不达标的药瓶由最低位灌针5补灌药液。具体为，在称重工位1上，只采用最低位灌针5补液，其他灌针5正常灌装，直到无药液流出，未达标的药瓶均通过最低位灌针5补液，从而，减少了药瓶的移动次数，使操作更加简单，提高了工作效率。
本实施例中，分液容器4倾斜设置，相邻灌针5中，后方的灌针5与分液容器4上高位的出液口41连接，前方的灌针5与分液容器4上低位的出液口41连接。分液容器4的倾斜角为ａ，0°＜ａ≤10°。药液灌装装置还包括供药装置7、进液阀8和缓冲罐9，供药装置7和缓冲罐9通过进液管路连接，进液管路上设有进液阀8，缓冲罐9与分液容器4通过连接管路连接。分液容器4的顶部设有进液口42，缓冲罐9与分液容器4的进液口42通过连接管路连接。
该药液灌装装置的具体灌装步骤如下：
第一步. 灌装排空（以，灌针5数为8个，称重工位1的秤数为8个为例，各灌针5沿药瓶输送方向F从前至后标号为A1-A8，各秤由前至后标号为B1-B8，各灌针5与称重工位1上各秤分别对准）
a)    缓冲罐9向分液容器4中间断进液，实现分液容器4内的无气泡填充；
b)    药瓶向前称动，单次走瓶个数为8个，向称重工位1上连续进3组瓶（依据扇形块周期）；
c)    待药瓶到达秤上方，灌针5插入瓶口；
d)    使用边灌边称，将各个管路分别排空；
e)    单次排空后继续走瓶，完成后续两组灌装；
f)    完成排空，进入装量校准模式。(如果有定量灌装则进入装量校准；无一直进行边灌边称则不进入装量校准)；
第二步. 装量校准
a)    单次走瓶个数为8个，连续进瓶；
b)    待整组8个药瓶到达各秤上方后，各灌针5插入瓶口（整组8个药瓶从前至后标号为C1-C8号瓶）；
c)    8个秤分别获取每个药瓶的空瓶重量，按照目标装量进行单次灌装；
d)    获取灌装后的总重，计算每个灌装泵61灌装的净重值；
e)    缓存单次灌装的净重值，用于判断是否进行装量校准；
f)    判断每瓶装量是否合格，如果合格，则继续下一组药瓶灌装；如果不合格，则跳转至c步骤，此时的目标装量为该药瓶上一轮得出的偏差值；
g)    连续判断2组药瓶单次灌装净重值，并内部比较偏差值，满足在一定范围之内（例如：内部偏差1%以内），计算平均值进行校准；
h)    继续灌装直到每个灌针5单次灌装合格，进行正常灌装生产。
第三步为.    尾液灌装（第一种方法）
a)    通过缓冲罐9称重传感器，检测缓冲罐9中药液低液位时，进行尾液灌装；
b)    单次走瓶个数为1个，连续进瓶，直到药瓶到达称重工位1上B8号秤上；
c)    获取药瓶皮重，按照目标装量灌装一次，获取灌装后的总重；
d)    计算偏差值，判断装量是否合格；
e)    如果合格，则结束单瓶灌装，走瓶继续下一瓶灌装；如果不合格，则跳转至c步骤继续灌装，此时的目标装量为上次计算的偏差值；
f)    继续灌装直到单瓶灌装合格，如果单瓶灌装超过n次（n为3、4、5……，n可设定）仍然不合格，则结束A8号灌针5的灌装，并向前走瓶；
g)    由A7号灌针5完成补液直至装量合格；
h)    继续走瓶，A7号灌针5灌装；
j)     重复c-h步流程直到A1号灌针5灌装完成。
或者第三步为.   尾液灌装（第二种方法）
a)    通过缓冲罐9称重传感器，检测缓冲罐9中药液低液位时，进行尾液灌装；
b)    单次走瓶个数为1个，连续进瓶，直到药瓶到达称重工位1上B2-B8号秤上；
c)    获取B2-B8号药瓶的皮重后灌装一次，继续单个走瓶；
d)    在B1号秤上逐一得出B2-B8号药瓶的偏差值，并逐一补液；
e)    完成一组药瓶后，继续称量接下来的B2-B8号药瓶皮重，灌装，单个走瓶；
f)    如果出现单个药瓶当中，某支灌装泵61出现装量低于20%时，停止该灌装泵61对应的灌装，并直接剔废；
g)    最后只进2号药瓶，A1号灌针5连接的灌装泵61运行超过30s装量仍未达到目标装量时，整个流程结束，停止生产。
前期灌装准备阶段，对管道中的空气进行排净，此时因受到管道中空气的影响，药瓶灌装量不达标，通过边称重边补液，从而使药瓶内装量合格，不会造成药品浪费。当分液容器4药量不足时，高位灌针5先定量灌装，低位灌针5再进行逐一补灌，从而对尾液（剩余药液）进行有效利用，确保最多一瓶药液量灌装不合格。
虽然本发明已以较佳实施例揭示如上，然而并非用以限定本发明。任何熟悉本领域的技术人员，在不脱离本发明技术方案范围的情况下，都可利用上述揭示的技术内容对本发明技术方案做出许多可能的变动和修饰，或修改为等同变化的等效实施例。因此，凡是未脱离本发明技术方案的内容，依据本发明技术实质对以上实施例所做的任何简单修改、等同变化及修饰，均应落在本发明技术方案保护的范围内。

Claims (9)

  1. 一种降低药液损耗的灌装方法，其特征在于：包括多个称重工位（1）和分液容器（4），所述分液容器（4）设有多个出液口（41），所述多个称重工位（1）上方对应设有多个并排布置的灌针（5），各所述出液口（41）与各灌针（5）分别通过管道（6）连接，各所述管道（6）上均设有灌装泵（61），对管道（6）内剩余药液的灌装，所述灌装方法包括：药瓶输送至称重工位（1）上，由第一灌针（5）对药瓶进行灌装，再由相邻的第二灌针（5）进行补液灌装或再由第三灌针（5）进行补液灌装，直至药瓶药液灌装量合格，以此分别对药瓶进行逐一灌装排空管道（6）内剩余药液。
  2. 根据权利要求1所述的降低药液损耗的灌装方法，其特征在于：所述第一灌针（5）为一个灌针（5），所述第二灌针（5）为与已灌装相邻的灌针（5），所述第三灌针（5）为已灌装不相邻的灌针（5）。
  3. 根据权利要求1所述的降低药液损耗的灌装方法，其特征在于：所述灌装方法还包括在称重工位（1）上对药瓶进行定量灌装，并边称重边补液，使各药瓶中的药量达标。
  4. 根据权利要求1所述的降低药液损耗的灌装方法，其特征在于：所述灌装方法还包括：在称重工位（1）上进行称重，并同步灌装，对灌装量不达标的药瓶由低位灌针（5）补灌药液。
  5. 根据权利要求4所述的降低药液损耗的灌装方法，其特征在于：对灌装量不达标的药瓶由最低位灌针（5）补灌药液。
  6. 根据权利要求1所述的降低药液损耗的灌装方法，其特征在于：所述分液容器（4）倾斜设置，相邻灌针（5）中，后方的灌针（5）与分液容器（4）上高位的出液口（41）连接，前方的灌针（5）与分液容器（4）上低位的出液口（41）连接。
  7. 根据权利要求6所述的降低药液损耗的灌装方法，其特征在于：所述分液容器（4）的倾斜角为ａ，0°＜ａ≤10°。
  8. 根据权利要求1至7中任一项所述的降低药液损耗的灌装方法，其特征在于：所述药液灌装装置还包括供药装置（7）、进液阀（8）和缓冲罐（9），所述供药装置（7）和缓冲罐（9）通过进液管路连接，所述进液管路上设有进液阀（8），所述缓冲罐（9）与分液容器（4）通过连接管路连接。
  9. 根据权利要求8所述的降低药液损耗的灌装方法，其特征在于：所述分液容器（4）的顶部设有进液口（42），所述缓冲罐（9）与分液容器（4）的进液口（42）通过连接管路连接。
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