WO2022016397A1 - 羟丙甲纤维素空心胶囊 - Google Patents

羟丙甲纤维素空心胶囊 Download PDF

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Publication number
WO2022016397A1
WO2022016397A1 PCT/CN2020/103380 CN2020103380W WO2022016397A1 WO 2022016397 A1 WO2022016397 A1 WO 2022016397A1 CN 2020103380 W CN2020103380 W CN 2020103380W WO 2022016397 A1 WO2022016397 A1 WO 2022016397A1
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Prior art keywords
shell
housing
hollow
hollow capsule
fixing ring
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PCT/CN2020/103380
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English (en)
French (fr)
Inventor
俞愈
俞栋
俞三愈
俞学文
王孟军
Original Assignee
绍兴康可胶囊有限公司
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Application filed by 绍兴康可胶囊有限公司 filed Critical 绍兴康可胶囊有限公司
Priority to CN202080006151.1A priority Critical patent/CN113164405B/zh
Priority to PCT/CN2020/103380 priority patent/WO2022016397A1/zh
Publication of WO2022016397A1 publication Critical patent/WO2022016397A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules

Definitions

  • the invention belongs to the technical field of hollow capsules, in particular to a hypromellose hollow capsule.
  • Drugs in capsules are generally powders or granules that are irritating to the esophagus and gastric mucosa, or drugs that have a bad taste, are easily volatile, are easily decomposed by saliva in the oral cavity, and are easily inhaled into the trachea. These medicines are packed into capsules, which not only protect the medicinal properties of the medicines from being destroyed, but also protect the digestive organs and respiratory tract.
  • Hypromellose hollow capsule is a kind of capsule, which is mostly used in the preparation of rheumatoid arthritis in medicine, and belongs to pharmaceutical excipients.
  • the hollow capsule includes two outer shells and the medicine inside, and the two outer shells are mostly stuck together by frictional force, and in this way, the outer shell is easy to loosen after a long time, which may cause the medicine to overflow, affecting the storage time and efficacy of the medicine. .
  • the purpose of the present invention is to provide a kind of hypromellose hollow capsule, through the hollow limit column arranged inside the through hole and the limit groove, so that the hollow limit column can fix the first shell and the second shell more firmly , which reduces the occurrence of the drug spillage caused by the unstable closure of the hollow capsule.
  • the chamfer provided at the drug inlet of the first shell can prevent the drug from being scattered due to shaking to a certain extent, thereby improving the The tightness of the capsule solves the existing technical problems.
  • a hypromellose hollow capsule comprising a first shell, a second shell is sleeved on the upper side of the first shell, a chamfer is provided on the upper side of the first shell, a fixing ring is installed on the surface of the first shell, and the The inside of the ring is provided with a first clamping groove, and the lower end of the second casing is clamped with the first clamping groove;
  • the inside of the fixing ring is provided with a through hole, the upper and lower sides of the through hole are provided with a second card slot, the outer surface of the second shell extending into the first card slot is provided with a limit groove, and the inside of the limit groove and the through hole are provided with
  • the hollow limiting column is provided with triangular clamping blocks on both sides of the hollow limiting column, and the triangular clamping blocks are clamped with the second clamping slot.
  • annular conical block is installed at the bottom of the first clamping slot, and the annular conical block is clamped between the first casing and the second casing.
  • a backing plate is installed on the top of the inner wall of the second housing, and the medicine inlet of the first housing is matched with the backing plate.
  • a plurality of annular inclined plane clamping blocks are installed on the surface of the first casing, a plurality of annular grooves are formed on the inner wall of the second casing, and the annular inclined plane clamping blocks are clamped in the annular grooves.
  • the corners of the fixing ring are provided with rounded corners.
  • a plurality of annular grooves are evenly distributed on the inner wall of the second housing.
  • the hollow limit post is provided inside the through hole and the limit groove, so that the hollow limit post can fix the first shell and the second shell more firmly, and reduces the problem of the hollow capsule caused by unstable closure.
  • the situation that the medicine is scattered in the first case can be prevented to a certain extent by the chamfer provided at the medicine inlet of the first shell, thereby improving the tightness of the capsule.
  • FIG. 1 is a schematic three-dimensional structure diagram of an embodiment of the present invention
  • FIG. 2 is a schematic cross-sectional structure diagram of an embodiment of the present invention.
  • Fig. 3 is the partial enlarged structural schematic diagram of Fig. 2;
  • FIG. 4 is a schematic diagram of the structure at A in FIG. 3 .
  • a hypromellose hollow capsule which includes a first shell 2, and a second shell 1 is sleeved on the upper side of the first shell 2.
  • the first shell The upper side of 2 is provided with a chamfer 3, a fixing ring 4 is installed on the surface of the first casing 2, a first clamping groove 5 is opened inside the fixing ring 4, and the lower end of the second casing 1 is clamped with the first clamping groove 5;
  • the inside of the fixing ring 4 is provided with a through hole 6, and the upper and lower sides of the through hole 6 are provided with a second slot 10.
  • the outer surface of the second shell 1 extending into the first slot is provided with a limit slot 7, and the limit slot 7
  • a hollow limit post 8 is arranged inside the through hole 6 , a triangular block 9 is installed on both sides of the hollow limit post 8 , and the triangular block 9 is clamped with the second slot 10 .
  • One aspect of the application of this embodiment is: after the medicine is loaded into the first shell 2, the second shell 1 is sleeved on the upper side of the first shell 2, so that the lower end of the second shell 1 is clamped in the first slot 5 , and then insert the hollow limit post 8 into the through hole 6, so that one end of the hollow limit post 8 is clamped in the limit slot 7, so as to drive the triangular block 9 into the second slot 10, thus completing the alignment Installation of the first housing 2 and the second housing 1 .
  • the hollow limit post 8 can fix the first shell 2 and the second shell 1 more firmly, and reduce the problem of the hollow capsule caused by unstable closure.
  • the chamfer 3 provided at the medicine inlet of the first shell 2 can prevent the medicine from being scattered due to shaking to a certain extent, thereby improving the tightness of the capsule.
  • annular cone block 11 is installed at the bottom of the first clamping slot 5 , and the annular cone block 11 is clamped between the first casing 2 and the second casing 1 .
  • the cone-shaped block 11 can reduce the occurrence of medicine spilling from between the first casing 2 and the second casing 1 .
  • a backing plate 14 is installed on the top of the inner wall of the second housing 1 , the medicine inlet of the first housing 2 is fitted on the backing plate 14 , and the backing plate 14 is arranged with the chamfering angle provided by the second housing.
  • the tightness of the closure of the first casing 2 and the second casing 1 can be increased, so that the medicine in the first casing 2 is less likely to be scattered.
  • a plurality of annular inclined plane blocks 13 are mounted on the surface of the first casing 2 , and a plurality of annular grooves 12 are formed on the inner wall of the second casing 1 , and the annular inclined plane blocks 13 are clamped in the annular groove 12 Inside.
  • the corners of the fixing ring 4 are all provided with rounded corners.
  • a plurality of annular grooves 12 are evenly distributed on the inner wall of the second housing 1 .

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

一种羟丙甲纤维素空心胶囊，包括第一外壳，第一外壳的上侧套接有第二外壳，第一外壳的上侧设置有倒角，第一外壳的表面安装有固定环，固定环的内部开设有第一卡槽，第二外壳的下端与第一卡槽卡接；固定环的内部开设有通孔，通孔的上下两侧均开设有第二卡槽。通过在通孔和限位槽的内部设置的空心限位柱，使空心限位柱可以将第一外壳与第二外壳固定更加牢固，降低了空心胶囊因闭合不稳导致的药物散出的情况发生，通过在第一外壳的进药口处设置的倒角，可以起到一定的防止药物因晃动散出的情况，从而提高了胶囊的严密性。

Description

羟丙甲纤维素空心胶囊 技术领域
本发明属于空心胶囊技术领域，特别是涉及一种羟丙甲纤维素空心胶囊。
 背景技术
用胶囊装的药物，一般都是对食道和胃粘膜有刺激性的粉末或颗粒，或口感不好、易于挥发、在口腔中易被唾液分解，以及易吸入气管的药。这些药装入胶囊，既保护了药物药性不被破坏，也保护了消化器官和呼吸道。羟丙甲纤维素空心胶囊是一种胶囊剂，其在医药方面多用于风湿性关节炎的配药中，属于药用辅料。
 技术问题
空心胶囊包括两个外壳和内部的药物，而两个外壳大多是直接通过摩擦力卡在一起，而这样设置，时间久了外壳容易松动，从而可能导致药物溢出，影响药物的存放时间和药效。
 技术解决方案
本发明的目的在于提供一种羟丙甲纤维素空心胶囊，通过在通孔和限位槽的内部设置的空心限位柱，使空心限位柱可以将第一外壳与第二外壳固定更加牢固，降低了空心胶囊因闭合不稳导致的药物散出的情况发生，通过在第一外壳的进药口处设置的倒角，可以起到一定的防止药物因晃动散出的情况，从而提高了胶囊的严密性，解决了现有的技术问题。
为解决上述技术问题，本发明是通过以下技术方案实现的：
一种羟丙甲纤维素空心胶囊，包括第一外壳，第一外壳的上侧套接有第二外壳，第一外壳的上侧设置有倒角，第一外壳的表面安装有固定环，固定环的内部开设有第一卡槽，第二外壳的下端与第一卡槽卡接；
固定环的内部开设有通孔，通孔的上下两侧均开设有第二卡槽，第二外壳伸入第一卡槽的外表面开设有限位槽，限位槽和通孔的内部设置有空心限位柱，空心限位柱的两侧安装有三角卡块，三角卡块与第二卡槽卡接。
可选的，第一卡槽的底部安装有环状锥形块，环状锥形块卡接在第一外壳与第二外壳之间。
可选的，第二外壳内壁的顶部安装有垫板，第一外壳的进药口配合在垫板上。
可选的，第一外壳的表面安装有多个环形斜面卡块，第二外壳的内壁开设有多个环形槽，环形斜面卡块卡接在环形槽内。
可选的，固定环的边角处均设置有圆角。
可选的，多个环形槽均布在第二外壳的内壁上。
 有益效果
本发明的一个实施例通过在通孔和限位槽的内部设置的空心限位柱，使空心限位柱可以将第一外壳与第二外壳固定更加牢固，降低了空心胶囊因闭合不稳导致的药物散出的情况发生，通过在第一外壳的进药口处设置的倒角，可以起到一定的防止药物因晃动散出的情况，从而提高了胶囊的严密性。
当然，实施本发明的任一产品并不一定需要同时达到以上所述的所有优点。
 附图说明
图1为本发明一实施例的立体结构示意图；
图2为本发明一实施例的剖面结构示意图；
图3为图2的局部放大结构示意图；
图4为图3中A处结构示意图。
 本发明的最佳实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
为了保持本发明实施例的以下说明清楚且简明，本发明省略了已知功能和已知部件的详细说明。
请参阅图1-4所示，在本实施例中提供了一种羟丙甲纤维素空心胶囊，包括第一外壳2，第一外壳2的上侧套接有第二外壳1，第一外壳2的上侧设置有倒角3，第一外壳2的表面安装有固定环4，固定环4的内部开设有第一卡槽5，第二外壳1的下端与第一卡槽5卡接；
固定环4的内部开设有通孔6，通孔6的上下两侧均开设有第二卡槽10，第二外壳1伸入第一卡槽的外表面开设有限位槽7，限位槽7和通孔6的内部设置有空心限位柱8，空心限位柱8的两侧安装有三角卡块9，三角卡块9与第二卡槽10卡接。
本实施例一个方面的应用为：把药物装入第一外壳2后，将第二外壳1套接在第一外壳2上侧，使第二外壳1的下端卡接在第一卡槽5内，然后将空心限位柱8插入通孔6内，使空心限位柱8的一端卡接在限位槽7内，从而带动三角卡块9卡入第二卡槽10内，从而完成了对第一外壳2和第二外壳1的安装。
通过在通孔6和限位槽7的内部设置的空心限位柱8，使空心限位柱8可以将第一外壳2与第二外壳1固定更加牢固，降低了空心胶囊因闭合不稳导致的药物散出的情况发生，通过在第一外壳2的进药口处设置的倒角3，可以起到一定的防止药物因晃动散出的情况，从而提高了胶囊的严密性。
在本实施例的一个方面中，第一卡槽5的底部安装有环状锥形块11，环状锥形块11卡接在第一外壳2与第二外壳1之间，设置的环状锥形块11，可以减少药物由第一外壳2和第二外壳1之间洒出的情况发生。
在本实施例的一个方面中，第二外壳1内壁的顶部安装有垫板14，第一外壳2的进药口配合在垫板14上，设置的垫板14与第二外壳设置的倒角相配合，可以增加第一外壳2与第二外壳1闭合的严密性，从而使第一外壳2内的药物更不容易散出。
在本实施例的一个方面中，第一外壳2的表面安装有多个环形斜面卡块13，第二外壳1的内壁开设有多个环形槽12，环形斜面卡块13卡接在环形槽12内。
在本实施例的一个方面中，固定环4的边角处均设置有圆角。
在本实施例的一个方面中，多个环形槽12均布在第二外壳1的内壁上。
需要说明的是，该装置中应用到的结构材质，均与胶囊的材质相同。
本说明书选取并具体描述这些实施例，是为了更好地解释本发明的原理和实际应用，从而使所属技术领域技术人员能很好地理解和利用本发明。本发明仅受权利要求书及其全部范围和等效物的限制。

Claims (6)

  1. 一种羟丙甲纤维素空心胶囊，其特征在于，包括：第一外壳（2），第一外壳（2）的上侧套接有第二外壳（1），第一外壳（2）的上侧设置有倒角（3），第一外壳（2）的表面安装有固定环（4），固定环（4）的内部开设有第一卡槽（5），第二外壳（1）的下端与第一卡槽（5）卡接；
    固定环（4）的内部开设有通孔（6），通孔（6）的上下两侧均开设有第二卡槽（10），第二外壳（1）伸入第一卡槽的外表面开设有限位槽（7），限位槽（7）和通孔（6）的内部设置有空心限位柱（8），空心限位柱（8）的两侧安装有三角卡块（9），三角卡块（9）与第二卡槽（10）卡接。
  2. 如权利要求1所述的一种羟丙甲纤维素空心胶囊，其特征在于，第一卡槽（5）的底部安装有环状锥形块（11），环状锥形块（11）卡接在第一外壳（2）与第二外壳（1）之间。
  3. 如权利要求1所述的一种羟丙甲纤维素空心胶囊，其特征在于，第二外壳（1）内壁的顶部安装有垫板（14），第一外壳（2）的进药口配合在垫板（14）上。
  4. 如权利要求1所述的一种羟丙甲纤维素空心胶囊，其特征在于，第一外壳（2）的表面安装有多个环形斜面卡块（13），第二外壳（1）的内壁开设有多个环形槽（12），环形斜面卡块（13）卡接在环形槽（12）内。
  5. 如权利要求1所述的一种羟丙甲纤维素空心胶囊，其特征在于，固定环（4）的边角处均设置有圆角。
  6. 如权利要求4所述的一种羟丙甲纤维素空心胶囊，其特征在于，多个环形槽（12）均布在第二外壳（1）的内壁上。
PCT/CN2020/103380 2020-07-22 2020-07-22 羟丙甲纤维素空心胶囊 WO2022016397A1 (zh)

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CN110115685A (zh) * 2019-06-19 2019-08-13 江苏力凡胶囊有限公司 一种充液用带锁合结构的空心硬胶囊
CN211050315U (zh) * 2019-08-13 2020-07-21 浙江华光胶囊股份有限公司 一种适用于中药胶囊制剂的空心胶囊
CN211050267U (zh) * 2019-08-15 2020-07-21 新昌县联通胶囊有限公司 一种植物空心胶囊

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