WO2022010683A1 - Topical vitamin c composition - Google Patents

Topical vitamin c composition Download PDF

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Publication number
WO2022010683A1
WO2022010683A1 PCT/US2021/039388 US2021039388W WO2022010683A1 WO 2022010683 A1 WO2022010683 A1 WO 2022010683A1 US 2021039388 W US2021039388 W US 2021039388W WO 2022010683 A1 WO2022010683 A1 WO 2022010683A1
Authority
WO
WIPO (PCT)
Prior art keywords
topical composition
skin
acid
total weight
topical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2021/039388
Other languages
English (en)
French (fr)
Inventor
Steven M. HERNANDEZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Topix Pharmaceuticals Inc
Original Assignee
Topix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Topix Pharmaceuticals Inc filed Critical Topix Pharmaceuticals Inc
Priority to EP21838714.0A priority Critical patent/EP4171537A4/en
Priority to JP2022581333A priority patent/JP7844362B2/ja
Priority to CN202180055869.4A priority patent/CN116075310A/zh
Publication of WO2022010683A1 publication Critical patent/WO2022010683A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Definitions

  • Each of the antioxidants in the antioxidant system may be present, individually or cumulatively, in a concentration of from any of above 0 wt.%, about 0.01 wt.%, about 0.05 wt.%, about 0.1 wt.%, about 0.15 wt.%, about 0.2 wt.%, about 0.25 wt.%, about 0.3 wt.%, about 0.35 wt.%, or about 0.4 wt.% to any of about 0.45 wt.%, about 0.5 wt.%, about 0.55 wt.%, about 0.6 wt.%, about 0.65 wt.%, about 0.7 wt.%, about 0.75 wt.%, about 0.8 wt.%, about 0.85 wt.%, about 0.9 wt.%, about 0.95 wt.%, about 1 wt.%, about 1.5 wt.%, about 2 wt.%, about 3 wt.%, about
  • the cosmetically acceptable excipient includes water in the topical composition in an amount of from about 5 wt.% to about 95 wt.%, about 10 wt.% to about 95 wt.%, about 20 wt.% to about 80 wt.%, from about 35 wt.% to about 70 wt.%, or from about 50 wt.% to about 60 wt.%, based on total weight of the topical composition.
  • the cosmetically acceptable excipient includes an emulsifier.
  • Suitable emulsifiers include, without limitations, PEG- 30 Dipolyhydroxystearate, PEG-4 Dilaurate, PEG-8 Dioleate, PEG-40 Sorbitan Peroleate, PEG-7 Glyceryl Cocoate, PEG-20 Almond Glycerides, PEG-25 Hydrogenated Castor Oil, Glyceryl Stearate (and) PEG-100 Stearate , PEG-7 Olivate, PEG-8 Oleate, PEG-8 Laurate, PEG-60 Almond Glycerides, PEG-20 Methyl Glucose Sesquistearate, PEG-40 Stearate, PEG- 100 Stearate, PEG-80 Sorbitan Laurate, Steareth-2, Steareth-12, Oleth-2, Ceteth-2, Laureth-4, Oleth-10, Oleth-10/Poly oxyl 10 Oleyl Ether, Ceteth-10,
  • the ethers include, for example, benzyl ethyl ether
  • the aldehydes include, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial and bourgeonal
  • the ketones include, for example, the ionones, a- isomethylionone and methyl cedryl ketone
  • the alcohols include anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol
  • the hydrocarbons include mainly the terpenes and balsams.
  • esters of linear C6-C24 fatty acids with linear C3-C24 alcohols esters of branched G,- C 13 carboxyl acids with linear C6-C24 fatty alcohols, esters of linear C6-C24 fatty acids with branched alcohols, especially 2-ethylhexanol, esters of hydroxycarboxylic acids with linear or branched C6-C22 fatty alcohols, especially dioctyl malates, esters of linear and/or branched fatty acids with polyhydric alcohols (for example propylene glycol, dimer diol or trimer triol) and/or Guerbet alcohols, for example caproic acid, caprylic acid, 2-ethylhexanoic acid, capric acid, lauric acid, isotridecanoic acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, elaidic acid, pet
  • diol esters such as ethylene glycol dioleate, ethylene glycol diisotridecanoate, propylene glycol di(2-ethylhexanoate), propylene glycol diisostearate, propylene glycol dipelargonate, butanediol diisostear
  • Suitable agents that absorb UV light, provide photo protection to the skin, and optionally provide sunless tanning may include a compound of formula I:
  • the two R 4 groups together form a — (C3-C8)alkyl-group, a — (C 2 -C 6 )alkyl-Y — (C 2 -C 6 )alkyl-group or a — (C 1 -C 6 )alkyl-Y' — (C 1 -C 6 )alkyl-group
  • the two R 1 groups together form a — (C 3 -C 8 )alkyl-group, a — (C 2 -C 6 )alkyl-Y — (C 2 -C 6 )alkyl-group or
  • R 2 is H, (C 1 -C 6 )alkyl or aryl, wherein aryl is optionally substituted with one or more Z 1 groups
  • R 3 is H, (C 1 -C 6 )alkyl or aryl, wherein aryl is optionally substituted with one or more Z 1 groups
  • each R n1 is independently selected from H and (C 1 -C 6 )alkyl, wherein any (C 1 -C 6 )alkyl of R n1 is optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) halogen; each R p1 is independently (C 1 -C 6 )alkyl; and
  • each R f is: each Z 1 is independently selected from (C 1 -C 6 )alkyl, halogen, — CN, — OR n1 , — NR q1 R r1 —, NR n1 CORp1, — NR n1 C0 2 R P1 , N0 2 , — C(0)R n1 , — C(0)0R n1 and — C(0)NR q1 R r1 , wherein any (C 1 -C 6 )alkyl of Z 1 is optionally substituted with one or more (e.g.
  • These substances can be selected, in particular, from cinnamic acid derivatives, salicylic acid derivatives, camphor derivatives, triazine derivatives, b,b-diphenylacrylate derivatives, p-aminobenzoic acid derivatives and polymeric filters and silicone filters, which are described in the WO93/04665. Further examples of organic filters are indicated in patent application EP-A 0 487 404.
  • Phenylbenzotriazole derivatives Drometrizole trisiloxane, for example marketed by Rhodia Chimie under the name “Silatrizole”,
  • the phrase “effective amount” refers to an amount of a topical composition of the present disclosure, or component thereof, effective to treat a skin condition as noted above, including a range of effects, from a detectable local improvement in an area of topical application to substantial relief of symptoms to an improvement in one or more aesthetic criteria, including, but not limited to, a perceived improvement in damage from free radicals from sunlight (UVB, UVA, Visible Light), HEV (blue) light, Infrared (IR), pollution, irritants, allergens, and various environmental toxins, skin wrinkles, appearance of fine lines, skin roughness, skin sagging, skin firmness, skin elasticity, age spots, hyperpigmentation, scars, skin surface irregularities, rosacea, acne, psoriasis, skin’s regenerative and renewal process, weather beaten appearance, yellowing, redness, dryness, ichthyosis, and other damaging skin conditions.
  • the instant disclosure is also directed to a method of preparing any of the topical compositions described herein.
  • the method includes producing any of the topical compositions described herein by combining an ascorbate component, above 0 wt.% to about 1 wt.% of an antioxidant system that includes green tea polyphenols, and a optionally at least one cosmetically acceptable excipient.
  • the topical composition may be formulated into a serum, gel, lotion, cream, pad applied formulation, and the like.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
PCT/US2021/039388 2020-06-29 2021-06-28 Topical vitamin c composition Ceased WO2022010683A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP21838714.0A EP4171537A4 (en) 2020-06-29 2021-06-28 Topical vitamin c composition
JP2022581333A JP7844362B2 (ja) 2020-06-29 2021-06-28 ビタミンｃ局所組成物
CN202180055869.4A CN116075310A (zh) 2020-06-29 2021-06-28 局部用维生素c组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063045409P 2020-06-29 2020-06-29
US63/045,409 2020-06-29

Publications (1)

Publication Number Publication Date
WO2022010683A1 true WO2022010683A1 (en) 2022-01-13

Family

ID=79032921

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/039388 Ceased WO2022010683A1 (en) 2020-06-29 2021-06-28 Topical vitamin c composition

Country Status (5)

Country Link
US (2) US12350351B2 (enExample)
EP (1) EP4171537A4 (enExample)
JP (1) JP7844362B2 (enExample)
CN (1) CN116075310A (enExample)
WO (1) WO2022010683A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022076834A1 (en) * 2020-10-09 2022-04-14 Topix Pharmaceuticals, Inc. Methods and compositions for therapeutic skin treatments in dermatological procedures affecting skin's barrier
JP2023112988A (ja) * 2022-02-02 2023-08-15 日光ケミカルズ株式会社 ポルフィリン産生抑制剤とそれを配合した化粧料および皮膚外用剤
KR102916081B1 (ko) * 2023-11-07 2026-01-22 주식회사 코스메카코리아 지용성 비타민 c 유도체 및 갈릭애씨드를 함유하는 지질나노입자, 이를 유효성분으로 함유하는 화장료 조성물, 및 그 제조방법

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US20220202671A1 (en) * 2020-12-17 2022-06-30 L'oreal Metal sequestering cosmetic composition
CA3206451A1 (en) * 2021-02-10 2022-08-18 Felipe A. Donate Solvent compositions with antioxidants
AU2023260846A1 (en) * 2022-04-28 2024-12-12 Kenvue Brands Llc Topical compositions containing vitamin c
KR102975102B1 (ko) * 2023-11-24 2026-06-09 (주) 비에스티 항노화 화장료 조성물 및 이의 제조 방법
WO2026120367A1 (en) * 2024-12-06 2026-06-11 Shiseido Company, Ltd. Facial oil compositions

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022076834A1 (en) * 2020-10-09 2022-04-14 Topix Pharmaceuticals, Inc. Methods and compositions for therapeutic skin treatments in dermatological procedures affecting skin's barrier
US11865138B2 (en) 2020-10-09 2024-01-09 Topix Pharmaceuticals, Inc. Methods and compositions for therapeutic skin treatments in dermatological procedures affecting skin's barrier
US12440508B2 (en) 2020-10-09 2025-10-14 Topix Pharmaceuticals, Inc. Methods and compositions for therapeutic skin treatments in dermatological procedures affecting skin's barrier
JP2023112988A (ja) * 2022-02-02 2023-08-15 日光ケミカルズ株式会社 ポルフィリン産生抑制剤とそれを配合した化粧料および皮膚外用剤
KR102916081B1 (ko) * 2023-11-07 2026-01-22 주식회사 코스메카코리아 지용성 비타민 c 유도체 및 갈릭애씨드를 함유하는 지질나노입자, 이를 유효성분으로 함유하는 화장료 조성물, 및 그 제조방법

Also Published As

Publication number Publication date
JP7844362B2 (ja) 2026-04-13
EP4171537A1 (en) 2023-05-03
US20210401682A1 (en) 2021-12-30
US12350351B2 (en) 2025-07-08
JP2023532111A (ja) 2023-07-26
US20250302705A1 (en) 2025-10-02
EP4171537A4 (en) 2024-10-23
CN116075310A (zh) 2023-05-05

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