WO2022009824A1 - Composition bactéricide - Google Patents

Composition bactéricide Download PDF

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Publication number
WO2022009824A1
WO2022009824A1 PCT/JP2021/025266 JP2021025266W WO2022009824A1 WO 2022009824 A1 WO2022009824 A1 WO 2022009824A1 JP 2021025266 W JP2021025266 W JP 2021025266W WO 2022009824 A1 WO2022009824 A1 WO 2022009824A1
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Prior art keywords
weakly acidic
aqueous solution
mass
concentration
liquid agent
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PCT/JP2021/025266
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English (en)
Japanese (ja)
Inventor
歩 高橋
美希 人見
秀樹 風間
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株式会社トクヤマデンタル
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Priority to JP2022535311A priority Critical patent/JPWO2022009824A1/ja
Publication of WO2022009824A1 publication Critical patent/WO2022009824A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/08—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/08—Liquid soap, e.g. for dispensers; capsuled
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Definitions

  • the present invention relates to a bactericidal composition. More specifically, the present invention relates to a weakly acidic hypochlorous acid aqueous bactericidal composition having an enhanced rust preventive effect.
  • hypochlorous acid in an aqueous solution changes depending on the pH. Specifically, most in weakly acidic region of pH of about 3 to 6 is present as a molecular form of hypochlorous acid (HClO), at pH9 or more basic region dissociated hypochlorite ion (OCl -) In the strongly acidic region (for example, less than pH 3), the generation of chlorine molecule (Cl 2) becomes predominant as the pH decreases.
  • molecular hypochlorous acid (HClO) has an extremely high bactericidal effect, and it is said that the bactericidal effect is about 80 times that of ionic hypochlorous acid (OCl ⁇ ).
  • chlorine-based disinfectants and fungicides are known to have metal corrosiveness, and the same applies to weakly acidic hypochlorous acid.
  • the weakly acidic hypochlorous acid water is more corrosive than the aqueous hypochlorite solution such as sodium hypochlorite having a high pH, and corrodes the metal at a lower concentration in a short time.
  • a sterilizing cleaning agent consisting of an organic acid and a salt thereof, a sterilizing cleaning agent to which an inorganic rust preventing agent is added, and a sterilizing cleaning agent to which a buffering agent is added have been proposed.
  • Patent Document 2 states that "one or more (A) selected from hypochloric acid and hypochlorite alkali metal salts, polyhydric alcohol derivative type surfactants, cationic surfactants and amphoteric surfactants.
  • Patent Document 3 describes that it is possible to effectively suppress metal corrosion by adding a buffering agent to a hypochlorous acid-based aqueous solution that has been conventionally used as a bactericidal agent.
  • a buffering agent an organic acid and a salt of an organic acid are preferable.
  • Japanese Unexamined Patent Publication No. 2019-20209 Japanese Unexamined Patent Publication No. 2002-161011 International Publication No. 2006/057311 Japanese Patent Laid-Open No. 2000-109887 Public Relations Japanese Patent Application Laid-Open No. 2010-138101
  • the inorganic rust preventives of phosphoric acid and polyphosphoric acid used in Patent Document 2 exert a rust preventive effect by depositing a metal salt on the surface of a metal and forming a film.
  • a rust preventive when such a rust preventive is used, there is only a problem that a part of rust is generated due to unevenness of the film and a problem that deposits remain on the metal surface even after washing with water.
  • the organic acid is immediately oxidized by hypochlorous acid, and hypochlorous acid is also reduced, deactivating the bactericidal ability, so that long-term storage is not possible, and even if it is mixed immediately before, it cannot be stored.
  • the buffering agent preferably used for imparting the rust preventive effect is an organic acid and a salt of an organic acid, and has the same problems as described above.
  • the present invention has a weakly acidic hypochlorous acid that is less corrosive to metals (has a rust preventive effect) and does not contain a component that reduces the bactericidal ability during storage or a component that easily remains on the surface of the substance to be sterilized after use. It is an object of the present invention to provide a bactericidal composition based on hypochlorous acid water.
  • the pH at which (A) molecular hypochlorous acid and (B) nonionic surfactant are dissolved is 3.
  • the nonionic surfactant of (B) is carbon-carbon in the molecule. It is preferably a compound having no multiple bonds, and more preferably at least one compound selected from the group consisting of a polyglycerin fatty acid ester and a fluorine-based nonionic surfactant.
  • the total concentration of the weakly acidic effective chlorine concentration in the hypochlorite aqueous solution (mass ppm) expressed as C A
  • B the non-ionic surfactant contained in the weakly acidic hypochlorite solution It represents (mass ppm) in C B, wherein the weakly acidic hypochlorite solution that can be incorporated into said (C) organic acids and the total concentration of the salt (mass ppm) expressed as C C, the weakly acidic hypochlorous said that may be included in the aqueous acid solution
  • D the total concentration of the ionic surfactant (mass ppm) expressed as C D
  • the weakly acidic total concentration cytoplasm of hypochlorite aqueous solution that can be incorporated into a metal ion (amount ppm) Is expressed by CE it is preferable that at least all the conditions represented by the following formulas (1) to (3) are satisfied, and all the conditions represented by the following formulas (1) to (4) are satisfied. More preferred.
  • the second form of the present invention is a bactericidal detergent comprising the bactericidal composition of the present invention.
  • the sterilizing detergent (hereinafter, also referred to as “the sterilizing detergent of the present invention") is preferably a sterilizing detergent for cleaning / or sterilizing an article whose surface is formed of metal at least in part. ..
  • the third embodiment of the present invention comprises a first liquid agent composed of a weakly acidic hypochlorous acid aqueous solution containing no component (B) and a second liquid agent composed of an aqueous solution of the component (B).
  • a two-component kit for preparing a bactericidal composition of the present invention by mixing a liquid agent and a second liquid agent in a predetermined ratio, wherein the first liquid agent is mixed with the predetermined ratio.
  • the ratio of the masses of the two liquid agents is (second liquid agent mass / first liquid mass) ratio: X, X is 0.01 or more and 10 or less, and the weakly acidic hypochlorous acid aqueous solution of the first liquid agent.
  • the effective chlorine concentration in the above is equivalent to the effective chlorine concentration obtained by multiplying the effective chlorine concentration of the bactericidal composition, which is the preparation target, by (1 + X), and the concentration of the component (B) in the aqueous solution of the second liquid agent.
  • the fourth aspect of the present invention comprises a first liquid agent composed of a weakly acidic hypochlorous acid aqueous solution containing no component (B) and a second liquid agent composed of an aqueous solution of the component (B).
  • a two-component kit for preparing a bactericidal composition of the present invention by mixing a liquid agent, a second liquid agent, and water supplied from the outside in a predetermined ratio, wherein the above-mentioned predetermined ratio is used.
  • the mass ratio of the second liquid agent and the water to the mass of the first liquid agent to be mixed is the ratio (second liquid agent mass / first liquid mass) ratio: Y and (water mass / first liquid mass): Z, respectively.
  • the effective chlorine concentration of the first liquid agent in the weakly acidic hypochlorous acid aqueous solution is the bactericidal property which is the preparation target.
  • the concentration of the component (B) in the aqueous solution of the second liquid is equivalent to the effective chlorine concentration obtained by multiplying the effective chlorine concentration of the composition by (1 + Y + Z).
  • the two-component kit is characterized in that it is equivalent to the concentration obtained by multiplying the concentration of the component by ⁇ (1 + Y + Z) / Y ⁇ .
  • the bactericidal composition of the present invention contains molecular hypochlorous acid (HClO) as an active ingredient, it has high bactericidal properties and its pH is similar to that of the conventional bactericidal composition composed of a weakly acidic hypochlorous acid aqueous solution. In addition, it has the feature that it is relatively safe for the human body. Furthermore, despite being a so-called chlorine-based substance, it has low metal corrosiveness (hard to rust metal), can be stored stably, and does not generate deposits on the surface of the substance to be sterilized after use. Has.
  • HEO molecular hypochlorous acid
  • the bactericidal composition of the present invention can be imparted with a rust preventive effect by adding a nonionic surfactant to the "weakly acidic hypochlorous acid water" obtained by the study of the present inventors. It was made based on the finding. Further studies based on these findings revealed that nonionic surfactants not only have a rust preventive effect, but are also specific in that they are less likely to decompose molecular hypochlorite than ionic surfactants. It was found that it has various properties. Therefore, the above-mentioned effect can be obtained by blending a non-ionic surfactant and substantially eliminating the organic acid and its salt and the ionic surfactant, which have been conventionally used as rust preventives. It was a success.
  • the nonionic surfactant functions as a rust preventive in the system of a weakly acidic hypochlorous acid aqueous solution, and as far as the present inventors know. , There is no report example showing that.
  • a basic hypochlorite aqueous solution such as an aqueous solution of sodium hypochlorite or an aqueous solution in which a buffer is added to make the solution neutral to acidic.
  • the purpose of adding a surfactant in such a system is not expected to have a rust preventive effect.
  • Patent Document 4 states that "a first agent containing a polyglycerin fatty acid ester and a pH adjuster, a second agent containing sodium hypochlorite or ozone as a main component, and water are mixed and mixed.
  • the composition of a sterilizing detergent for foods having a pH of 3 to 7 is described, and the polyglycerin fatty acid ester corresponds to a nonionic surfactant.
  • the purpose of the addition is said to be to enhance the cleaning effect.
  • the sterilizing detergent composition is stored separately in two agents, since it contains a pH adjuster such as phosphoric acid, the storage stability is low when both agents are mixed into one liquid. The problem of deposits is also a concern.
  • Patent Document 5 states that "a specific alcohol compound (A), a surfactant (B), hypochlorous acid, hypochlorite and a compound that releases hypochlorous acid in water are selected. "Antibacterial agent composition containing one or more compounds (C) and having a weight ratio of (A) to (B) of 2 or less: (A) / (B)” is described. However, here as well, the purpose of blending the surfactant and the like is to exert an antibacterial action against fungi adhering to the fibers of the textile product or relatively intricate parts of the product having a hard surface. ..
  • the preferable pH of the antibacterial agent composition is 6 to 14, and further 8 to 13.5, and a specific aqueous solution of sodium hypochlorite is used.
  • a buffer which may be added to adjust the pH. Therefore, it is considered that the weakly acidic hypochlorous acid aqueous solution system has the same problem as the sterilizing detergent composition of Patent Document 4.
  • the surfactant is added for the purpose of preventing deterioration of the bactericidal property due to the addition of the rust preventive agent, and can be used in combination with the rust preventive agent. It is a prerequisite.
  • the bactericidal composition of the present invention has an excellent feature that it exhibits a rust preventive effect substantially without containing an organic acid, a salt thereof and an ionic surfactant, and therefore, for example, at least one. It can be suitably used as a sterilizing detergent for cleaning and / or sterilizing an article whose surface is made of metal.
  • the bactericidal composition of the present invention and the bactericidal detergent of the present invention will be described in more detail, focusing on each component contained therein.
  • the expression of x to y means that it is a numerical value x or more and a numerical value y or less, and when a unit is attached only to y, x also has the same unit. Means that.
  • the effective chlorine concentration in the bactericidal composition of the present invention is preferably 2 ppm to 2000 ppm from the viewpoint of bactericidal effect and low corrosiveness to metals (rust preventive effect). If the effective chlorine concentration is less than 2 ppm, it tends to be difficult to obtain a sufficient bactericidal effect, and if it exceeds 2000 ppm, the bactericidal effect is saturated, and (B) a rust preventive effect due to the nonionic surfactant is obtained. It becomes difficult. From the viewpoint of sterilization efficiency, the effective chlorine concentration is preferably 10 ppm to 1500 ppm, more preferably 30 to 1000 ppm.
  • the effective chlorine concentration refers to chlorine molecules dissolved in an aqueous solution, an oxidizing chlorine compound (for example, molecular hypochlorous acid), and an oxidizing chlorine atom-containing ion (for example, ionic hypochlorous acid). It means the total chlorine equivalent concentration of hypochlorous acid), and more specifically, it means the concentration obtained by converting the mass-based concentration of each component into the mass-based chlorine concentration and then summing them up.
  • the effective chlorine concentration means the effective chlorine concentration derived from the molecular type hypochlorous acid in the pH range in which almost the entire amount of hypochlorous acid exists in the molecular type. It will be.
  • the concentration measured by the absorptiometry with an iodine reagent is adopted as the effective chlorine concentration, and the measurement is performed using, for example, the effective chlorine concentration measurement kit AQ-202 (Shibata Kagaku Co., Ltd.). Can be done.
  • Such weakly acidic hypochlorite water is, for example, an electrolytic method for electrolyzing an aqueous sodium chloride solution, a hydrochloric acid method for adding hydrochloric acid to a basic hypochlorite aqueous solution, and a raw material aqueous solution consisting of a hypochlorite aqueous solution.
  • An electrolytic method for electrolyzing an aqueous sodium chloride solution a hydrochloric acid method for adding hydrochloric acid to a basic hypochlorite aqueous solution
  • a raw material aqueous solution consisting of a hypochlorite aqueous solution can be produced by an ion exchange method in which is treated with an ion exchange resin.
  • the (B) nonionic surfactant contained in the weakly acidic hypochlorous acid aqueous solution constituting the bactericidal agent composition of the present invention has a hydrophilic portion in the molecule.
  • a surfactant consisting of a compound that has an oil-friendly portion and does not become an ion when dissolved in water, for example, polyglycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, and fatty acid polyethylene.
  • Glycol fatty acid polyoxyethylene sorbitan, polyglycerin alkyl ether, polyoxyethylene alkyl ether, fluorine-based nonionic surfactant and the like can be used. It is preferable to use a polyglycerin fatty acid ester or a fluorine-based nonionic surfactant from the viewpoint of material stability, and it is more preferable to use a polyglycerin fatty acid ester from the viewpoint of easy availability.
  • Nonionic surfactants that do not contain carbon-carbon multiple bonds in such molecules are commercially available, for example, polyglyceryl laurate-10 ⁇ C 12 H 24 O 2- (C 3 H 6 O). 2 ) 10 ⁇ , polyglyceryl-4 lauryl ether ⁇ C 12 H 26 O- (C 3 H 6 O 2 ) 4 ⁇ , polyoxyethylene (5) lauryl ether, perfluoroalkyl group-containing nonionic surfactant, etc. It can be suitably used.
  • the blending amount of the (B) nonionic surfactant contained in the weakly acidic hypochlorous acid aqueous solution is usually 30% by mass to 15% by mass based on the mass of the weakly acidic hypochlorous acid aqueous solution.
  • it is preferably 50% by mass to 1.5% by mass, and more preferably 100% by mass to 1500% by mass.
  • the available chlorine concentration in the weakly acidic hypochlorite solution (mass ppm) in C A (B) a nonionic surfactant the total concentration (mass ppm) when expressed in C B, which is the ratio of the two C B / C a is, preferably satisfies the relation of 0.5 ⁇ C B / C a ⁇ 1000 of 0. 7 ⁇ C B / C a ⁇ 900, to satisfy the particular 1.0 ⁇ C B / C a ⁇ 800 relationships, more preferred.
  • the weakly acidic hypochlorous acid aqueous solution constituting the bactericidal agent composition of the present invention contains (C) an organic acid and a salt thereof, and (D) ions. It should be substantially free of sex surfactants.
  • substantially not contained means that it is not contained at all or is not positively (or consciously) added, and is inevitably contained within a range that does not adversely affect storage stability and the like. Allows. Upper limit of the allowable amount, the effective chlorine concentration: depending on the C A, usually expressed as a ratio to the effective chlorine concentration of each concentration is the concentration that satisfies the following formula (2) and (3).
  • C C the expressed weakly acidic hypochlorite solution that can be incorporated into said (C) organic acids and the total concentration of the salt (mass ppm)
  • C D the weakly acidic hypochlorous It represents the total concentration (mass ppm) of the (D) ionic surfactant that can be contained in the chloric acid aqueous solution.
  • the absolute concentrations of (C) and (D) are both preferably 10 mass ppm or less, and more preferably 5 mass ppm or less, based on the total mass of the weakly acidic hypochlorous acid aqueous solution. It is preferably 1 mass ppm or less, and most preferably 1 mass ppm or less.
  • Examples of the (C) organic acid and its salt that are not substantially contained include citric acid, malonic acid, glutaric acid, adipic acid, sebacic acid, fumaric acid, maleic acid, and salts thereof.
  • the (D) ionic surfactant which is not substantially contained, as an anionic surfactant, a carboxylic acid type such as an aliphatic carboxylate and a polyoxyethylene alkyl ether carboxylate, and a dialkylsulfowabite.
  • an anionic surfactant a carboxylic acid type such as an aliphatic carboxylate and a polyoxyethylene alkyl ether carboxylate, and a dialkylsulfowabite.
  • the molecular type hypochlorous acid in an aqueous solution is expressed by the following formula: 2HClO ⁇ 2HCl + O 2 and / or 3HClO ⁇ 2HCl + HClO 3
  • 2HClO ⁇ 2HCl + O 2 and / or 3HClO ⁇ 2HCl + HClO 3 Autolysis according to the above, and rapid reduction decomposition when in contact with organic substances with reducing properties, including fungi that are sterilized objects: HClO ⁇ HCl + (O) It is known that it disappears due to.
  • metal ions derived from the raw material may be contained in the weakly acidic hypochlorous acid aqueous solution.
  • a hypochlorite such as sodium hypochlorite
  • metal ions derived from the raw material may be contained in the weakly acidic hypochlorous acid aqueous solution.
  • an acid or a buffer is added to an aqueous solution of sodium hypochlorite to make it weakly acidic, not only the metal ion derived from the raw material is contained as it is, but also the metal ion derived from the buffer agent is contained.
  • the weakly acidic hypochlorite aqueous solution constituting the fungicidal composition of the present invention preferably the C E / C A satisfies the condition represented by the following formula (4), the following equation (4 It is particularly preferable to satisfy the conditions shown in ⁇ ).
  • Patent Document 1 In order to obtain a weakly acidic hypochlorous acid aqueous solution that satisfies the above conditions, for example, the method described in Patent Document 1 can be adopted. That is, a molecular form that dissolves in the mixed solution by mixing a raw material aqueous solution composed of an aqueous solution of a metal salt of hypochloric acid and a weakly acidic ion exchange resin and performing ion exchange between metal ions and hydrogen ions. Ion exchange step to generate hypochlorous acid; Separation step to separate a weakly acidic ion exchange resin from the mixed solution after the ion exchange step and obtain a target aqueous solution consisting of an aqueous solution in which molecular hypochlorous acid is dissolved.
  • the amount ratio of the raw material aqueous solution to be mixed and the weakly acidic ion exchange resin in the ion exchange step is the total ion exchange equivalent of the weakly acidic ion exchange resin ( EIE ) and the metal ions in the raw material aqueous solution.
  • the weakly acidic hypochlorous acid aqueous solution constituting the bactericidal agent composition of the present invention may be, if necessary, an antibacterial metal ion such as silver ion, zinc ion or copper ion, or a metal ion supply source.
  • an antibacterial metal ion such as silver ion, zinc ion or copper ion, or a metal ion supply source.
  • the bactericidal agent composition of the present invention all the components are mixed in advance to a predetermined concentration to prepare the weakly acidic hypochlorous acid aqueous solution, and the solution is prepared. It may be used as a bactericidal composition as it is, or a weakly acidic hypochlorous acid aqueous solution having a concentration several to several tens of times higher than that at the time of use is prepared, diluted with water and weakly acidic hypochlorous acid having a predetermined concentration. An aqueous chloric acid solution may be used as the bactericidal composition of the present invention.
  • a two-component kit also a kit for preparing the sterilizing detergent of the present invention shown in the following (1) or (2) for long-term storage.
  • the ratio of the mass of the second liquid agent to the mass of the first liquid agent to be mixed in the predetermined ratio is (second liquid agent mass / first liquid mass) ratio: X, X is preferably 0.01 to 10.
  • the effective chlorine concentration of the first solution in the weakly acidic hypochlorous acid aqueous solution is effective for the bactericidal composition which is the preparation target. It is equivalent to the effective chlorine concentration obtained by multiplying the chlorine concentration by (1 + X), and the concentration of the component (B) in the aqueous solution of the second solution is the component (B) of the bactericidal composition which is the preparation target.
  • the two-component kit characterized in that the concentration of is equivalent to the concentration multiplied by ⁇ (1 + X) / X ⁇ .
  • a first liquid agent consisting of a weakly acidic hypochlorous acid aqueous solution containing no component (B) and a second liquid agent consisting of an aqueous solution of the component (B), the first liquid agent and the second liquid agent.
  • a two-component kit for preparing the bactericidal composition of the present invention by mixing water and water supplied from the outside in a predetermined ratio. The ratio of the mass of the second liquid agent and the mass ratio of the water to the mass of the first liquid agent to be mixed in the predetermined ratio is (second liquid agent mass / first liquid mass) ratio: Y and (water mass / first liquid mass).
  • Y is 0.01 to 2, preferably 0.02 to 2, more preferably 0.5 to 1.5
  • Z is 2 to 50, preferably 2 to 40, and more. It is preferably 2 to 35
  • the effective chlorine concentration of the first liquid agent in the weakly acidic hypochlorous acid aqueous solution is the effective chlorine obtained by multiplying the effective chlorine concentration of the bactericidal composition which is the preparation target by (1 + Y + Z).
  • the concentration of the component (B) in the aqueous solution of the second liquid is equivalent to the concentration, and the concentration of the component (B) in the bactericidal composition to be prepared is ⁇ (1 + Y + Z) / Y ⁇ .
  • the two-component kit characterized in that it is equivalent to the multiplied concentration.
  • the equivalent concentration means that the concentration is the same as the calculated concentration, or is within ⁇ 20%, preferably within ⁇ 10% of the concentration.
  • the effective chlorine concentration in the bactericidal composition which is the preparation target is preferably 30 to 1000 ppm, particularly 50 to 500 ppm, and the concentration of the component (B) is 50% by mass to 1.5% by mass, particularly. It is preferably 100 to 1500 mass ppm.
  • none of the liquid agents in the kits (1) and (2) substantially contains (C) an organic acid and a salt thereof, and (D) an ionic surfactant.
  • the bactericidal composition of the present invention contains molecular hypochlorous acid as an active ingredient and is not basic or strongly acidic, which requires careful handling. Therefore, it has a high bactericidal effect and is relatively safe and easy to handle. Therefore, it is useful for sterilization in a wide range of fields such as hospitals, food processing factories, educational facilities, and long-term care facilities.
  • the bactericidal composition of the present invention is suitable for the conventional weakly acidic hypochlorous acid aqueous solution-based bactericidal composition, which corrodes the metal (generates rust on the metal) and does not easily leave deposits after washing with water. It has excellent features not seen. For this reason, in addition to articles made of plastic, rubber, tile, brick, cement, glass, wood, cloth, non-woven fabric, vinyl, leather, ceramic, etc., articles containing metal, especially rusty steel, cobalt chrome, silver, etc. It can also be used for articles containing zinc, brass, etc.
  • the bactericidal detergent of the present invention is characterized by containing the bactericidal agent composition of the present invention.
  • the sterilizing detergent is a cleaning agent for removing stains adhering to the article, and / or a sterilizing agent for killing or removing (sterilizing or sterilizing) microorganisms such as bacteria adhering to the article.
  • the bactericidal cleaning agent of the present invention is suitable as a sterilizing cleaning agent for cleaning and / or sterilizing articles whose surface is at least partially formed of metal, particularly rust-prone steel, cobalt chrome, silver, zinc, brass and the like. Can be used.
  • the disinfectant detergent of the present invention may consist only of the disinfectant composition of the present invention, but may contain various additives and the like as long as it does not impair the above-mentioned effects or is a compounding method.
  • a thickener to form a gel or a paste.
  • the thickener it is preferable to use inorganic particles, and it is preferable to use inorganic particles having an average primary particle diameter of 5 nm or more and 100 nm or less.
  • the method of using the bactericidal composition of the present invention and the bactericidal detergent of the present invention is not particularly limited, and the bactericidal composition may be used in contact with the object by, for example, spraying, coating, dipping or the like. Specifically, for example, a method of spraying a place to be sterilized with a sprayer such as a trigger and then wiping it off, a method of immersing a sterilizing object in a bactericidal composition and then washing it with water, and a method of sterilizing with an ultrasonic sprayer.
  • a sprayer such as a trigger and then wiping it off
  • a method of immersing a sterilizing object in a bactericidal composition and then washing it with water and a method of sterilizing with an ultrasonic sprayer.
  • a method of mistizing the composition and spraying it into the space a method of soaking the bactericidal composition in a material that can be impregnated with a cloth or a non-woven fabric and rubbing the object, a method of rubbing the object with the bactericidal composition using a brush or a syringe, Examples include a method of applying to an object to be sterilized, washing with water, and wiping. It is also possible to enhance the cleaning effect by using ultrasonic waves in the method of immersing the sterilizing object in the bactericidal composition. Further, the present bactericidal composition may be used as a cleaning liquid when a wash dispenser used for cleaning and sterilizing a medical device is used.
  • Nonionic surfactant containing multiple bonds -Polyoxyethylene (10) oleyl ether (manufactured by Nikko Chemicals Co., Ltd., hereinafter abbreviated as "POEOE").
  • the resin was allowed to stand until it settled, and the aqueous solution of hypochlorite, which was the supernatant liquid, was collected in a polyethylene container through a # 200 filter cloth so that the resin would not enter.
  • the solution was left at room temperature for 3 hours until the pH reached 4.8.
  • the effective chlorine concentration after standing was 9000 ppm.
  • Evaluation method (3-1) Measurement of effective chlorine concentration (manufacturing) A part of the aqueous sodium hypochlorite solution and the weakly acidic hypochlorite water is used as a sample solution, and the sample solution is diluted with ion-exchanged water at the following dilution ratio according to the effective chlorine concentration of the raw material solution for measurement. A sample was prepared, and the effective chlorine concentration after dilution was measured with the effective chlorine concentration measurement kit AQ-202 (Shibata Kagaku Co., Ltd.). The effective chlorine concentration of the sample solution was determined from the measurement results and the dilution ratio.
  • Effective chlorine concentration of raw material solution 300ppm or less not diluted ⁇ Effective chlorine concentration of raw material solution 301-900ppm: dilution ratio 3 times ⁇ Effective chlorine concentration of raw material solution 901-3000ppm: dilution ratio 10 times ⁇ Effective chlorine concentration of raw material solution 3001-15000ppm: Dilution factor 50 times
  • Example 1 18.7 ml of ion-exchanged water was added to 1.3 ml of weakly acidic hypochlorite water having an effective chlorine concentration of 9000 ppm prepared in (2) above, and the mixture was stirred with a stirrer for 1 minute.
  • 0.4 g of the surfactant PGLE and 19.6 g of ion-exchanged water were weighed and stirred with a stirrer for 10 minutes until uniform.
  • 20 g of each prepared aqueous solution was placed in a 50 ml screw tube bottle and mixed by hand for 10 seconds to obtain a disinfectant composition.
  • the resulting metal ions total concentration (mass ppm) of the germicidal composition was measured to determine the C E / C A value.
  • Example 2 to 5 Comparative Examples 1 to 3 A bactericidal composition was prepared in the same procedure as in Example 1 except that the type of surfactant used was changed as shown in Table 1, and rust was evaluated and storage stability was evaluated. The evaluation results are shown in Tables 2 and 3.
  • Example 1 In the weakly acidic hypochlorous acid water having an effective chlorine concentration of 300 ppm (Comparative Example 1), clear rust was confirmed after 5 minutes, but in the disinfectant composition having an effective chlorine concentration of 300 ppm, Examples 1 to 3 were found after 1 day. No rust was confirmed in. Rust was slightly confirmed in Example 4 after 24 hours and in Example 5 after 3 hours. Further, in Examples 1 to 4, no change was confirmed in the effective chlorine concentration and pH after storage at room temperature for 1 day, but in Example 5 using a surfactant containing a carbon-carbon multiple bond in the molecule. The effective chlorine concentration began to gradually decrease immediately after production, but remained at 50 ppm until 30 minutes later.

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Abstract

La présente invention concerne une composition bactéricide caractérisée en ce qu'elle comprend une solution aqueuse d'acide hypochloreux faiblement acide ayant un pH de 3,0 à 7,0, dans laquelle sont dissous (A) de l'acide hypochloreux moléculaire et (B) un tensioactif non ionique, la solution aqueuse d'acide hypochloreux faiblement acide ne contenant sensiblement aucun (C) acide organique ou sel correspondant et sensiblement aucun (D) tensioactif ionique.
PCT/JP2021/025266 2020-07-07 2021-07-05 Composition bactéricide WO2022009824A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023228881A1 (fr) * 2022-05-25 2023-11-30 株式会社トクヤマデンタル Agent antirouille pour solution aqueuse d'acide hypochloreux, fongicide et son procédé de préparation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000109887A (ja) * 1998-10-02 2000-04-18 Kao Corp 食品の殺菌洗浄剤組成物
JP2008093514A (ja) * 2006-10-06 2008-04-24 Univers Point:Kk 弱酸性水とその製造方法、およびこれを含有する殺菌剤と消臭剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000109887A (ja) * 1998-10-02 2000-04-18 Kao Corp 食品の殺菌洗浄剤組成物
JP2008093514A (ja) * 2006-10-06 2008-04-24 Univers Point:Kk 弱酸性水とその製造方法、およびこれを含有する殺菌剤と消臭剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BOKIN BOBAI, vol. 33, no. 6, 2005, pages 257 - 262, ISSN: 0385-5201 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023228881A1 (fr) * 2022-05-25 2023-11-30 株式会社トクヤマデンタル Agent antirouille pour solution aqueuse d'acide hypochloreux, fongicide et son procédé de préparation

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