WO2022004843A1 - 外用組成物 - Google Patents

外用組成物 Download PDF

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Publication number
WO2022004843A1
WO2022004843A1 PCT/JP2021/024951 JP2021024951W WO2022004843A1 WO 2022004843 A1 WO2022004843 A1 WO 2022004843A1 JP 2021024951 W JP2021024951 W JP 2021024951W WO 2022004843 A1 WO2022004843 A1 WO 2022004843A1
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WO
WIPO (PCT)
Prior art keywords
mass
ethanol
external composition
acid
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/024951
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English (en)
French (fr)
Japanese (ja)
Inventor
翔太 井上
純子 丸川
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Rohto Pharmaceutical Co Ltd
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Rohto Pharmaceutical Co Ltd
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Priority to JP2022534110A priority Critical patent/JPWO2022004843A1/ja
Publication of WO2022004843A1 publication Critical patent/WO2022004843A1/ja
Anticipated expiration legal-status Critical
Priority to JP2024029035A priority patent/JP2024051122A/ja
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to an external composition. More specifically, the present invention relates to an external composition suitable for maintaining the cleanliness of the skin and protecting the skin.
  • Ethanol has a disinfecting effect against bacteria and viruses, and is used as a hand sanitizer. It may also be added to cosmetics, and its purpose is to have an astringent effect to tighten the skin, a cleansing effect to lift and remove sebum and dirt, and a refreshing effect due to heat dissipation during volatilization. ..
  • Ethanol is a volatile component, so while it has a disinfecting effect, it deprives the skin of oil and water when it volatilizes, weakening the barrier function, promoting the evaporation of water, and easily causing dryness of the skin.
  • Patent Document 1 shows that it is difficult to provide a cosmetic that contains a relatively large amount of ethanol and is suitable for people with dry skin or sensitive skin.
  • Moisturizers such as glycerin are used for the purpose of keeping moisture when applied to the skin and preventing / improving dryness.
  • glycerin Moisturizers such as glycerin are used for the purpose of keeping moisture when applied to the skin and preventing / improving dryness.
  • the comparative example described later it was confirmed that in the external composition containing a relatively large amount of ethanol, stickiness due to glycerin was felt and the usability was lowered.
  • composition is for external use and contains a relatively large amount of ethanol, it is required to have a formulation that suppresses drying by ethanol when applied to the skin and has an excellent usability.
  • the present invention provides the compositions listed below.
  • [1] Ethanol and (B) Containing at least one selected from the group consisting of erythritol, sorbitol, and xylitol.
  • A An external composition having an ethanol content of 32 to 85% by mass.
  • [2] (A) The external composition according to [1], wherein the content of the component (B) is 0.01 to 0.5 parts by mass with respect to 1 part by mass of ethanol.
  • the external composition according to [1] or [2] which further contains (C) water in an amount of 10% by mass or more.
  • [4] The external composition according to any one of [1] to [3], which is for disinfection.
  • FIG. 1 is a graph showing the evaluation results regarding the quick-drying property of the external composition in Test Example 2.
  • the external composition of the present invention contains at least one selected from the group consisting of (A) ethanol and (B) erythritol, sorbitol, and xylitol.
  • the external composition of the present invention contains ethanol as the component (A).
  • Ethanol may be produced from sugar such as glucose by alcoholic fermentation, or a commercially available product may be used.
  • the content of ethanol is 32 to 85% by mass with respect to the total amount of the external composition from the viewpoint of remarkably exerting the effect of the present invention.
  • the content of ethanol is, for example, 34% by mass or more, 36% by mass or more, 38% by mass or more, 40 with respect to the total amount of the external composition, from the viewpoint of remarkably exerting the effect of the present invention.
  • the content of ethanol is, for example, 84% by mass or less, 83% by mass or less, 82% by mass or less, 81 with respect to the total amount of the external composition, from the viewpoint of remarkably exerting the effect of the present invention.
  • Mass% or less 80% by mass or less, 79% by mass or less, 78% by mass or less, 77% by mass or less, 76% by mass or less, 75% by mass or less, 74% by mass or less, 73% by mass or less, 72% by mass or less. be able to.
  • the content of ethanol is, for example, 34 to 84% by mass, 36 to 83% by mass, and 38 to 82% by mass with respect to the total amount of the external composition, from the viewpoint of significantly exerting the effect of the present invention.
  • the ethanol content is preferably 60 to 80% by mass, preferably 63 to 78% by mass, from the viewpoint of disinfection for prevention of bacterial infection or virus infection. More preferably, it is more preferably 65 to 75% by mass, and particularly preferably 69 to 75% by mass.
  • the following is exemplified when the content of ethanol is shown by volume%.
  • the ethanol content is, for example, 50% by volume or more, 55% by volume or more, 60% by volume or more, 65 volumes with respect to the total volume of the external composition from the viewpoint of significantly exerting the effect of the present invention. % Or more, 70% by volume or more, and 75% by volume or more.
  • the ethanol content is, for example, 95% by volume or less, 90% by volume or less, and 85% by volume or less with respect to the total volume of the external composition from the viewpoint of significantly exerting the effect of the present invention. can do.
  • the ethanol content is, for example, 50 to 95% by volume, 55 to 90% by volume, 60 to 85 with respect to the total volume of the external composition from the viewpoint of significantly exerting the effect of the present invention. It can be% by volume, 65 to 85% by volume, 70 to 85% by volume, and 75 to 82% by volume.
  • the external composition of the present invention contains at least one selected from the group consisting of erythritol, sorbitol, and xylitol as the component (B).
  • the component (B) may be produced by hydrogenating (reducing) the sugar as a raw material, or a commercially available product may be used. From the viewpoint of remarkably exerting the effect of the present invention, the component (B) is preferably erythritol and / or sorbitol.
  • the content of the component (B) is preferably 0.01 to 20% by mass, more preferably 0.05 to 15% by mass, based on the total amount of the external composition, for example, from the viewpoint of significantly exerting the effect of the present invention. It is by mass, more preferably 0.1 to 10% by mass, particularly preferably 0.5 to 5% by mass, even more preferably 1 to 4% by mass, and most preferably 2 to 3% by mass.
  • the compounding ratio of the component (B) to the component (A) is appropriately changed and not limited depending on the type and content of the component (B), the mode of the formulation, and the like.
  • the content of the component (B) can be 0.01 to 0.5 parts by mass with respect to 1 part by mass of the content of (A) ethanol.
  • the external composition of the present invention is not limited, but preferably contains water for the purpose of preventing the precipitation of the component (B).
  • the water content is preferably 5 to 65% by mass, more preferably 10 to 50% by mass, still more preferably, based on the total amount of the external composition, for example, from the viewpoint of significantly exerting the effect of the present invention. It is 20 to 40% by mass, particularly preferably 20 to 30% by mass, and most preferably 22 to 28% by mass.
  • the external composition of the present invention contains, but is not limited to, a relatively large amount of ethanol, it is expected to suppress the growth of bacteria on the skin and / or attenuate the virus. Further, in another embodiment, by applying the external composition of the present invention to the skin, it becomes possible to maintain the cleanliness of the skin.
  • the component (B) coexists in addition to the component (A). It moisturizes the skin and suppresses drying by ethanol. By such an action, by applying the external composition of the present invention to the skin, it is possible to prevent the barrier function of the skin from being impaired and to protect the skin.
  • the external composition of the present invention is, for example, sterilizing / disinfecting fingers / skin, disinfecting / treating / preventing suppuration of wounds by sterilization, sterilizing / disinfecting general injuries / abrasions / cuts, and wound surfaces. Can be used for sterilization and disinfection.
  • the external composition of the present invention can be used, for example, for moisturizing the skin, converging the skin, and adjusting the texture of the skin.
  • the external composition of the present invention is preferably used for at least one selected from the group consisting of skin sterilization, disinfection, and skin moisturization.
  • the external composition of the present invention when used as a cosmetic, it is required to have an excellent usability when applied to the skin.
  • the component (B) coexists in addition to the component (A), quick-drying property is improved and improved when applied to the skin, and a more preferable smooth feeling can be obtained.
  • the term "smooth feeling" means that the surface shape of a substance is a non-sticky feel, such as the feel of sand when powder such as sand flows.
  • the external composition having a silky feeling when applied, the dynamic frictional force is reduced after the application as compared with before the application. In addition, it is expected that the convenience at the time of use will be enhanced.
  • the feeling of use when the external composition is applied to the skin is, for example, suppressing the drying of the skin by ethanol, improving and improving the quick-drying property, and / or obtaining a smooth feeling. It is preferable to mean that, and it is more preferable to mean two or more of these three kinds at the same time, to suppress the drying of the skin due to ethanol, to improve and improve the quick-drying property, and to obtain a silky feeling. It is particularly preferable to mean that (meaning these three kinds at the same time).
  • the external composition of the present invention can be used for disinfection by containing 65% by mass or more of ethanol.
  • the component (B) coexists in addition to the component (A), it has a quick-drying property and is expected to enhance the disinfecting effect against bacteria and viruses. In addition, it is expected that the convenience at the time of use will be enhanced.
  • the site to which the external composition is applied is not particularly limited as long as it is a site where a disinfecting effect and cleanliness are required, but examples thereof include skin, hair, and nails.
  • the skin to which the external composition is applied is preferably skin, and more preferably the skin of the hands (palms, fingers), face, feet, scalp, neck, chest, armpits, and back, and the palms, fingers, and armpits. Skin is particularly preferred.
  • the external composition of the present invention can be used as a skin external preparation in the form of a pharmaceutical product, a quasi-drug, or a cosmetic product, without limitation.
  • the composition may be mixed with a known base or carrier added to the skin external preparation (cosmetics, quasi-drugs, pharmaceuticals) to the extent that the effect of the present invention is not impaired. can.
  • the external composition of the present invention is a known form of a pharmaceutical product, a non-pharmaceutical product, or a cosmetic product, for example, a liquid agent (among others, a spray spray agent), a suspending agent, an emulsion, a cream agent, an ointment agent, or a gel agent.
  • a liquid agent among others, a spray spray agent
  • a suspending agent an emulsion, a cream agent, an ointment agent, or a gel agent.
  • Liniment agent, lotion agent, aerosol agent, powder agent, pap agent, sheet agent in which a sheet such as a non-woven fabric is impregnated with a chemical solution and the like can be mentioned.
  • a liquid agent among others, a spray type spray agent
  • a suspension agent an emulsion, a gel agent, and a lotion agent.
  • the external composition of the present invention is preferably a spray spray agent from the viewpoint of increasing the surface area of the droplets due to the atomization at the time of application and improving the quick-drying property. Further, although not limited, the spray spray agent is preferable from another viewpoint that the possibility of using an excessive amount at the time of application is suppressed.
  • cosmetics include lotions, milky lotions, creams, beauty essences, sunscreen cosmetics, and basic cosmetics such as body lotions.
  • Such an external composition is preferably intended for those who are susceptible to the effects of containing a relatively large amount of ethanol, and for example, for babies, infants, children, those with sensitive skin, and those who are sensitive. It is more preferable for skin, dry skin, fluctuating skin, and troubled skin.
  • the container for filling the external composition of the present invention is not particularly limited as long as it is used as a container for a pharmaceutical external preparation, a quasi-drug, or a cosmetic product.
  • a container material for example, a part or all, preferably all of the contact surface with the external composition is a polyolefin resin, an acrylic acid resin, a polyester, a polycarbonate, a fluororesin, a polyvinyl chloride, a polyamide, an ABS resin, and the like.
  • Examples thereof include a container made of at least one material selected from the group consisting of AS resin, polyacetal, modified polyphenylene ether, polyarylate, polysulfone, polyimide, cellulose acetate, aluminum, and glass.
  • the container material is, for example, polyethylene (PE) (high density polyethylene (HDPE), low density polyethylene (LDPE), ultra low density polyethylene, linear low density polyethylene (LLDPE), super Of polyethylene (including high molecular weight polyethylene, etc.), polypropylene (PP) (including isotactic polypropylene, syndiotactic polypropylene, atactic polypropylene, etc.), and ethylene-propylene copolymers, polymethylpentene, polybutene-1,1,2-polybutadiene
  • Polyethylene resins such as polyolefin resin, polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate and the like are preferable, and polyethylene, polypropylene and polyethylene terephthalate are more preferable.
  • the external composition of the present invention contains various components generally used in the fields of pharmaceuticals, quasi-drugs or cosmetics, for example, surfactants, as required, within the quantitative and qualitative range that does not impair the effects of the present invention.
  • Agents moisturizers, vegetable oils, blood circulation promoters, thickeners, refreshing agents, lubricants, preservatives, antioxidants, colorants, dispersants, chelating agents, pH regulators, fragrances, antibacterial ingredients, anti-inflammatory Ingredients, astringent ingredients, vitamins, peptides or derivatives thereof, amino acids or derivatives thereof, keratin softening ingredients, cell activating ingredients and the like can be blended.
  • these components can be blended individually by 1 type or in any combination of 2 or more types.
  • these components can be mixed with known bases or carriers and incorporated into external compositions.
  • the external composition of the present invention can be produced by mixing these components according to a conventional method.
  • Bases or carriers include, for example, liquid paraffins, squalanes, gelled hydrocarbons (such as plastic bases), ozokelite, ⁇ -olefin oligomers, light liquid paraffins and other hydrocarbons; methylpolysiloxanes, crosslinked methylpolysiloxanes, high.
  • the base or carrier can be used alone or in combination of two or more.
  • surfactant examples include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monoisostearate, sorbitan monostearate, penta-2-ethylhexyl diglycerol sorbitan, and tetra-2-ethylhexylate.
  • Solbitan fatty acid esters such as diglycerol sorbitan; propylene glycol fatty acid esters such as propylene glycol monostearate; polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50).
  • Polyoxyethylene hydrogenated castor oil 60 HCO-60
  • cured castor oil derivatives such as polyoxyethylene hydrogenated castor oil 80; polyoxyethylene monolaurylate (20) sorbitan (polysorbate 20), polyoxyethylene monostearate ( 20)
  • Polyoxyethylene sorbitan fatty acid esters such as sorbitan (polysorbate 60), polyoxyethylene monooleate (20) sorbitan (polysorbate 80), polyoxyethylene isostearate (20) sorbitan; polyoxyethylene monococonut oil fatty acids Glyceryl; polyglyceryl monolaurate; glycerin alkyl ether; alkyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; amines such as stearylamine and oleylamine; polyoxyethylene / methylpolysiloxane copolymer, laurylPEG Examples thereof include silicone-based surfactants such as -9 polydimethylsiloxyeth
  • Moisturizers include, for example, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, polyethylene glycol, diglycerin trehalose; sodium hyaluronate, heparin analogs, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, High molecular weight compounds such as chitosan; amino acids such as glycine, aspartic acid, arginine; natural moisturizing factors such as sodium lactate, urea, sodium pyrrolidone carboxylate; lipids such as ceramide, cholesterol, phospholipids; chamomile extract, hamamelis Examples thereof include plant-extracted extracts such as extracts, cha-extracts, and perilla extracts.
  • polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, polyethylene glycol, diglycerin trehalose
  • sodium hyaluronate such as
  • Vegetable oils include avocado oil, flaxseed oil, camellia oil, peanut oil, macadamia nut oil, walnut oil, corn oil, olive oil, safflower oil, kyonin oil, cinnamon oil, jojoba oil, grape seed oil, sunflower oil, almond oil, Southern ka oil, rapeseed oil, sesame oil, castor oil, palm oil, hardened palm oil, palm oil, palm kernel oil, mokuro kernel oil, mokuro, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil , Tea seed oil, evening primrose oil, kukui nut oil, hazelnut oil, orange oil, chamomile oil and the like.
  • blood circulation promoters include acetylcholine, ictamol, caffeine, capsaicin, cantalist tincture, gamma oryzanol, gamma oryzanol, gamma oryzanol, zingerone, cepharanthin, swertia japonica extract, tannic acid, capsaicin, tolazoline, tocopherol nicotinate, and benzyl nicotinate.
  • Examples include ester.
  • thickener examples include guar gum, locust bean gum, carrageenan, xanthan gum, carboxymethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydrophobicized hydroxypropyl methyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, and carboxyvinyl polymer.
  • Alkyl methacrylate copolymer polyethylene glycol, bentonite, (hydroxyethyl acrylate / sodium acryloyldimethyltaurine) copolymer, (acryloyldimethyltaurine ammonium / vinylpyrrolidone) copolymer and the like.
  • Examples of the refreshing agent include menthol and its derivatives, camphor, borneol, geraniol, cineole, anethole, limonene, eugenol and other terpenes (these may be d-form, l-form or dl-form); eucalyptus oil. , Bergamot oil, peppermint oil, cool mint oil, spare mint oil, uikyo oil, camphor oil, keihi oil, rose oil, terpene oil and other essential oils.
  • lubricant examples include silica, talc, zinc oxide, magnesium oxide, titanium oxide, silicic acid anhydride, kaolin, sericite, hydroxyapatite, stearic acid, calcium stearate, magnesium stearate, boric acid, polyethylene glycol and the like. Can be mentioned.
  • preservative examples include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and benzyl paraoxybenzoate. , Methyl paraoxybenzoate, phenoxyethanol, chlorobutanol and the like.
  • antioxidants examples include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride and the like.
  • Examples of the colorant include inorganic pigments and natural pigments.
  • dispersant examples include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinylpyrrolidone, methyl vinyl ether / maleic anhydride crosslinked copolymer, organic acid and the like.
  • chelating agent examples include EDTA / 2 sodium salt, EDTA / calcium / 2 sodium salt, phytic acid, gluconic acid, polyphosphoric acid, metaphosphoric acid and the like. Of these, sodium edetate is preferable.
  • Examples of the pH adjuster include inorganic acids (hydrochloride, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), and inorganic bases (potassium hydroxide, hydroxylation). Examples include sodium), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.) and the like.
  • antibacterial component examples include chlorhexidine, salicylic acid, benzalkonium chloride, cetyltrimethylammonium bromide, acrinol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, and the like.
  • examples thereof include triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, pyractone olamine, myconazole and the like.
  • anti-inflammatory component examples include allantin and its derivatives (eg, alcroxa, allantin, etc.), caramine, tranexamic acid, glycyrrhizinic acid or its derivatives or salts thereof (eg, dipotassium glycyrrhizinate, monoammonium glycyrrhetinate, etc.), glycyrrhetin.
  • allantin and its derivatives eg, alcroxa, allantin, etc.
  • caramine tranexamic acid
  • glycyrrhizinic acid or its derivatives or salts thereof eg, dipotassium glycyrrhizinate, monoammonium glycyrrhetinate, etc.
  • Acids or derivatives thereof or salts thereof eg, glycyrrhetinic acid, stearyl glycyrrhetinate, etc.
  • zinc oxide aminocaproic acid
  • azulene and its derivatives eg, guaiazulene, azulene, etc.
  • tocopherol acetate pyridoxin hydrochloride, menthol, camphor, terepine.
  • Oils, indomethacin, salicylic acid or derivatives thereof, steroids or derivatives thereof or salts thereof eg, hydrocortisone, prednisolone), ufenamate, bufexamac, ibprofenpiconol, azelaic acid, plants (eg, comfrey, aurene, dokudami, chamomile, etc.)
  • Ingredients derived from (bilberry, Izayoibara, Enmeiso, etc.), etc. can be mentioned.
  • Convergent components include, for example, metal salts such as myoban, aluminum chloride, allantoin aluminum salt, zinc sulfocarbonate, basic aluminum lactate zinc lactate, zinc oxide, zinc sulfate, potassium aluminum sulfate; tannic acid, citric acid, lactic acid, succinic acid.
  • metal salts such as myoban, aluminum chloride, allantoin aluminum salt, zinc sulfocarbonate, basic aluminum lactate zinc lactate, zinc oxide, zinc sulfate, potassium aluminum sulfate; tannic acid, citric acid, lactic acid, succinic acid.
  • Ingredients derived from organic acids such as seaweed, thyme, tea, oolong tea, green tea, otogirisou, hamamelis, biwa, buttonpi, yukinoshita, louis boss, zinc sulphate, artichoke, chamomile, eucalyptus, lemon, rosemary, waremoko
  • vitamins examples include vitamin Es such as dl- ⁇ -tocopherol, dl- ⁇ -tocopherol acetate, dl- ⁇ -tocopherol succinate, and dl- ⁇ -tocopherol calcium succinate; riboflavin, flavin mononucleotide, flavin adenine.
  • Vitamin B2s such as dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinic acid ester; nicotinic acid, benzyl nicotinate, methyl nicotinate, ⁇ -butoxyethyl nicotinate, Nicotinic acids such as 1- (4-methylphenyl) ethyl nicotinate, nicotinic acid amide; ascorbic acid, ascorvigen-A, ascorbic acid stearate, ascorbic acid palmitate, dipalmitate L-ascorvir, 3- ⁇ - Vitamin Cs such as ethyl ascorbic acid, ascorbic acid palmitate 3Na, sodium ascorbic acid, ascorbic acid 2-glucoside, dehydroascorbic acid, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate; methylhesper
  • Examples of the peptide or its derivative include keratin-degrading peptide, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, and elastin.
  • amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, ⁇ -alanine, threonine, glutamine acid, glutamine, asparagine, aspartic acid, cysteine, and cystine.
  • keratin softening component examples include lactic acid, salicylic acid, glycolic acid salicylate, gluconic acid, citric acid, malic acid, phytic acid, urea, and sulfur.
  • the cell activating component examples include amino acids such as ⁇ -aminobutyric acid and ⁇ -aminocaproic acid, vitamins such as retinol, thiamine, riboflavin, pyridoxin hydrochloride and pantothenic acid, and ⁇ -hydroxy acids such as glycolic acid and lactic acid.
  • amino acids such as ⁇ -aminobutyric acid and ⁇ -aminocaproic acid
  • vitamins such as retinol, thiamine, riboflavin, pyridoxin hydrochloride and pantothenic acid
  • ⁇ -hydroxy acids such as glycolic acid and lactic acid.
  • examples thereof include tannin, flavonoid, saponin, allantin, and photosensitizer No. 301.
  • fragrance in addition to the known fragrances, plant-derived essential oils or animal-derived essential oils can be used.
  • the component containing vegetable oil emits a scent, it can be used as a fragrance.
  • the invention comprises (A) 32 to 85% by weight of ethanol, characterized by containing at least one selected from the group consisting of (B) erythritol, sorbitol, and xylitol.
  • the present invention relates to a usability improving agent in an external composition.
  • the type and content of the component (B), the mixing ratio of the component (A) and the component (B), the dosage form, the intended use, etc. are in accordance with the above description of [external composition].
  • the present invention comprises (A) an external composition containing 32 to 85% by mass of ethanol at least one selected from the group consisting of (B) erythritol, sorbitol, and xylitol.
  • the present invention relates to a method for improving the usability of an external composition, which is characterized by the above.
  • the type and content of the component (B), the mixing ratio of the component (A) and the component (B), the dosage form, the intended use, etc. are in accordance with the above description of [external composition].
  • the external composition of the present invention can be prepared by heating each component to 20 to 80 ° C. or dissolving the components at room temperature with stirring.
  • a known method can be used, and for example, an apparatus such as a blade type stirrer, a disper, or a homomixer can be used.
  • the external composition of the present invention can be obtained by cooling the melted and homogeneous mixture to room temperature.
  • the above-mentioned external composition having the content of the component (B) of 0.01 to 20% by mass.
  • the above-mentioned external composition which is a spray-type spray agent.
  • a usability improving agent in a composition for external use containing 32 to 85% by mass of ethanol which comprises at least one selected from the group consisting of (B) erythritol, sorbitol, and xylitol.
  • a usability improving agent in a composition for external use containing 50 to 95% by volume of ethanol which comprises at least one selected from the group consisting of (B) erythritol, sorbitol, and xylitol.
  • (B) A method for improving usability in a composition for external use containing 32 to 85% by mass of ethanol, which comprises at least one selected from the group consisting of erythritol, sorbitol, and xylitol.
  • (B) A method for improving usability in a composition for external use containing 50 to 95% by volume of ethanol, which comprises at least one selected from the group consisting of erythritol, sorbitol, and xylitol.
  • the above agent or method which is a spray type spray agent.
  • the length from the left end of the 10 cm line segment to the position of the diagonal line that was answered was measured for each question item and used as the answer value.
  • the item of moisturizing compression of dryness by ethanol
  • “feeling moisturized as if wet (not feeling dry at all)” is the best condition at 100, and “rough skin”.
  • “I feel like it dries (very dry)” is 0, which is the worst condition.
  • the score is 100 for both moisturizing (suppression of drying by ethanol) (Table 2) and smoothness (Table 3), the application site feels like sand while being moisturized as if it were wet. It means that it was evaluated as being in a free-flowing state.
  • the external composition was provided to the panelists in a state where each prescription could not be understood, and after the evaluation of each external composition, it was hand-washed and dried, and care was taken not to leave any residue on the application site at the next evaluation.
  • Table 4 shows the average score of the results of VAS evaluation.
  • Comparative Example 1-1 in which the content of ethanol was increased, after the ethanol volatilized, water did not easily remain on the skin, so that a silky feeling was felt, but the moisturizing feeling was inferior, and the skin was dried by ethanol. It was evaluated that it could be felt.
  • Comparative Example 1-2 the effect of coexisting glycerin, which is a polyhydric alcohol frequently used as a moisturizer, with ethanol was evaluated. Although a moisturizing sensation was obtained by glycerin, the silky sensation was significantly reduced, and it was evaluated that the glycerin felt sticky.
  • Example 1-1 compared with Comparative Example 1-1, although the moisturizing feeling was improved, the smooth feeling was not impaired and a high evaluation was obtained.
  • Example 1-2 using erythritol as a component, surprisingly moisturizing and smoothness are expected to be impaired in consideration of the results of Comparative Example 1-2. The result was that both the feeling and the feeling improved.
  • Example 1-3 and Example 1-4 xylitol and sorbitol are used as the component (B), respectively, but both the moisturizing feeling and the silky feeling are improved as the same tendency as in Example 1-2. Results were obtained.
  • Test Example 2-1 Evaluation of quick-drying property of external composition
  • An external composition was prepared by a conventional method according to the formulation shown in Table 5, and a test solution was obtained. About 3 g of each test solution was added to a petri dish having a diameter of 7 cm at 27 ° C. and an RH of 50 ⁇ 5%, and the weights were measured at 1 minute, 5 minutes, and 10 minutes from the initial weight at the start of measurement. This was done three times, the average value of the weight at this time for each time was plotted against time, and the slope of the straight line was calculated by the linear approximate straight line creation function (least squares method) by Excel of Microsoft Office.
  • Test Example 2-2 Evaluation of quick-drying property of external composition
  • Table 6 an external composition was prepared by a conventional method, and a test solution was obtained.
  • the time change of the weight due to the evaporation of the test solution was investigated by the same method as in Test Example 2-1 and the slope of the straight line obtained by the linear approximate straight line creation function (least squares method) was obtained.
  • the r-square value was 0.9950 or more in any straight line, and it was confirmed that the straight line approximation was appropriate.
  • Table 6 The results are also shown in Table 6.
  • the coefficient of dynamic friction of the test site (section 5 cm from the center of the artificial leather in the lateral direction) was measured under the conditions of load: 50 g and movement speed: 2 mm / min. Subsequently, 30 ⁇ L of the pharmaceutical product was applied to the test site, left for 2 minutes, and then the coefficient of dynamic friction was measured in the same manner. Then, the rate of change of the dynamic friction coefficient after the external composition was applied and left for 2 minutes with respect to the dynamic friction coefficient of the artificial leather before the external composition was applied was calculated. The results are shown in Table 7.

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JPH07165571A (ja) * 1993-09-21 1995-06-27 Shiseido Co Ltd 消毒用組成物
JPH07102294A (ja) * 1993-09-30 1995-04-18 Shiseido Co Ltd 殺菌洗浄用組成物
JP2004155712A (ja) * 2002-11-07 2004-06-03 Kenei Pharmaceutical Co Ltd 外用殺菌消毒剤
KR20070119970A (ko) * 2006-06-17 2007-12-21 장희찬 나노 은이 함유된 손 소독제
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