WO2021261971A1 - Composition pour le traitement de l'acné ou l'amélioration de la peau - Google Patents

Composition pour le traitement de l'acné ou l'amélioration de la peau Download PDF

Info

Publication number
WO2021261971A1
WO2021261971A1 PCT/KR2021/008052 KR2021008052W WO2021261971A1 WO 2021261971 A1 WO2021261971 A1 WO 2021261971A1 KR 2021008052 W KR2021008052 W KR 2021008052W WO 2021261971 A1 WO2021261971 A1 WO 2021261971A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
extract
purslane
ginger
broccoli
Prior art date
Application number
PCT/KR2021/008052
Other languages
English (en)
Korean (ko)
Inventor
박시헌
금영삼
Original Assignee
박시헌
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 박시헌 filed Critical 박시헌
Publication of WO2021261971A1 publication Critical patent/WO2021261971A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the present invention relates to a composition for treating acne or improving skin.
  • Acne vulgaris (acne vulgaris) is a common skin disease in adolescents and adults, and is an inflammatory disease that appears in the sebaceous glands of the skin.
  • T-zone areas where the forehead and nose.
  • adult acne is mainly caused by complex reasons such as stress, drinking, and irregular lifestyle, and occurs in various parts of the body such as the cheeks, chin, forehead, and neck.
  • adult acne occurs in pores clogged with sweat or waste products, and the recurrence rate is high.
  • the present invention is to provide a composition for treating acne or a composition for improving acne prone skin containing a natural extract to minimize skin irritation while exhibiting an antibacterial effect on acne-causing bacteria.
  • the present invention relates to a composition for treating acne or a composition for improving acne prone skin, comprising a ginger extract, green tea leaf extract, purslane extract, cucumber extract, centella asiatica extract and broccoli extract.
  • composition of the present invention may further comprise trehalose.
  • the ginger extract, green tea leaf extract, purslane extract, cucumber extract, centella asiatica extract and broccoli extract may each contain 0.5 to 5% by weight based on the total composition.
  • the total of the ginger extract, green tea leaf extract, purslane extract, cucumber extract, Centella asiatica extract and broccoli extract in the composition of the present invention may be included in an amount of 3 to 30% by weight of the total composition.
  • the ginger extract, green tea leaf extract, purslane extract, cucumber extract, centella asiatica extract and broccoli extract may be extracted from water, an organic solvent, or a mixture thereof.
  • ginger extract, green tea leaf extract, purslane extract, cucumber extract, centella asiatica extract and broccoli extract are each of ginger, green tea leaf, purslane, cucumber, centella asiatica and broccoli in water, methanol, ethanol, ethyl acetate and hexane.
  • One or a mixture of two or more selected from the group consisting of an extraction solvent may be used for extraction by a method such as cold acupuncture, warm acupuncture, or constant temperature vacuum extraction.
  • water, ethanol, or a mixture of water and ethanol is used as the extraction solvent.
  • each extract is independently extracted from each natural product (that is, each of ginger, green tea leaf, purslane, cucumber, centella asiatica and broccoli), or after mixing all of ginger, green tea leaf, purslane, cucumber, centella asiatica and broccoli It can be extracted simultaneously from this mixture.
  • composition of the present invention may be formulated as a liquid formulation, suspension or emulsion composition, and the like. Preferably formulated as an emulsion composition.
  • composition of the present invention may be used as a pharmaceutical or cosmetic for treating acne or for cleaning.
  • composition of the present invention ginger, green tea leaves, purslane, cucumber, centella asiatica and broccoli separately in an extraction solvent, respectively, and extracting at warm, room temperature or cold temperature (a); drying the extract obtained from step (a) to obtain a solid extract (b); And it can be prepared including the step (c) of mixing each solid extract of ginger, green tea leaf, purslane, cucumber, centella asiatica and broccoli.
  • the extraction solvent one or a mixture of two or more selected from the group consisting of water, methanol, ethanol, ethyl acetate and hexane may be used.
  • the step (c) comprises dissolving each extract of ginger, green tea leaf, purslane, cucumber, centella asiatica and broccoli in an organic solvent; and emulsifying an organic solvent in which each extract of ginger, green tea leaf, purslane, cucumber, centella asiatica and broccoli is dissolved in water together with a surfactant (eg, trehalose, etc.) to prepare an emulsion composition.
  • a surfactant eg, trehalose, etc.
  • composition of the present invention ginger, green tea leaves, purslane, cucumber, centella asiatica and broccoli all put in an extraction solvent, and extracting at warm, room temperature or cold temperature (a); drying the extract obtained from step (a) to obtain a solid extract (b); And it may be prepared including the step (c) of preparing a composition comprising the solid extract.
  • the extraction solvent may be one or a mixture of two or more selected from the group consisting of water, methanol, ethanol, ethyl acetate and hexane.
  • step (c) here, the step of dissolving the solid extract of ginger, green tea leaf, purslane, cucumber, centella asiatica and broccoli in an organic solvent; and preparing an emulsion composition by emulsifying an organic solvent in which the solid extract of ginger, green tea leaves, purslane, cucumber, centella asiatica and broccoli is dissolved in water together with a surfactant (eg, trehalose, etc.) have.
  • a surfactant eg, trehalose, etc.
  • Ginger is a monocotyledonous perennial plant of the Ginger family, and its root is used for food and medicine, and is known to be effective in promoting gastric juice secretion and enhancing digestion.
  • Green tea leaves are leaves of the tea tree (Camellia sinensis) and are known to have antioxidant effects.
  • Purslane (Portulaca oleracea) is an annual plant of the dicotyledonous purslane family, and dried out herbs are used medicinally and are known to be effective in preventing arteriosclerosis.
  • Cucumber (Cucumis sativus) is an annual vine of the dicotyledonous plywood family, Gourdaceae, and its fruits are used for food and are known to have the effect of excreting wastes from the body.
  • Centella asiatica is a dicotyledonous perennial plant of the Dicotyledonous family Umbilicalaceae family, and dried out plants are used medicinally and are known to have the effect of protecting the gastric mucosa.
  • Broccoli (Brassica oleracea var. italica) is an annual plant of the dicotyledonous papaveraceae mustard family, and small flower buds hanging from the tip of the stem are used for food or medicine, and it is known to promote calcium absorption and help bone health.
  • composition according to the present invention contains a natural extract, and is safe because it can minimize skin irritation while exhibiting an antibacterial effect on acne-causing bacteria.
  • 1 is a photograph of the results of testing the antimicrobial activity of a composition according to the present invention by a disk diffusion method.
  • composition according to the present invention is a photograph and graph of the results of testing the antimicrobial activity of the composition according to the present invention by optical analysis.
  • Example 1 Each extract obtained in Example 1 was purified with hexane and ethyl acetate. For each of the purified extracts, an indicator material was isolated and confirmed using HPLC.
  • HPLC analysis conditions are as follows:
  • UV absorbance meter 310 nm (Bio-Rad)
  • Each indicator substance is as follows:
  • composition with a capacity of 100 ml was prepared as follows with the composition and content of Table 2 below:
  • each component of the oil phase is mixed to prepare an oil phase mixture.
  • the active part that is, each solid extract obtained in Example 1
  • the oil phase in which each solid extract is dissolved is added to the aqueous phase mixture in which each component of the aqueous phase is mixed together with a surfactant, and then marked with purified water to make 100 ml while maintaining the temperature at 75°C. While maintaining the mixture at a temperature of 75° C., the mixture was stirred on a low-speed stirrer for 4 hours to prepare an emulsion composition according to the present invention.
  • Example 3 an antibacterial test for C. acnes (Cutibacterium acnes), which is an acne bacterium, was performed by the disk diffusion method as follows.
  • a composition containing a ginger solid extract, a green tea leaf solid extract, a purslane solid extract, a cucumber solid extract, a centella asiatica solid extract, and a broccoli solid extract (each prepared in Example 1 was used) and an antibiotic (ampicillin) alone ( Comparative Examples 1 to 7) were used.
  • composition of each control group (Comparative Examples 1 to 7) is shown in Table 3 below (unit of content (g/100ml)):
  • Example 8 a composition using sucrose instead of trehalose as a surfactant was used as a control (Comparative Example 8) (the content of each component is the same).
  • the antibacterial activity inhibition radius for the composition of Example 3 and the compositions of Comparative Examples 1 to 7 was measured.
  • the experimental results are shown in Table 5 and FIG. 1 (here, the suppression radius is a value obtained by subtracting the disk area from the area of the circle, and the unit is mm 2 ).
  • composition of Example 3 according to the present invention did not achieve the antibacterial effect of the positive control, ampicillin antibiotic, side effects such as resistance expression occurred during administration of the antibiotic, the composition of the present invention was a safe herbal extract. It was found that it exhibits satisfactory antibacterial activity with few side effects.
  • Example 3 10 ml of RCM medium (dispersed in distilled water) in which the C. ances strain is present at a concentration of 10 8 /ml is placed in a test tube.
  • the composition of Example 3 and the composition of Comparative Example 8 are put and mixed to have a concentration of 10 ⁇ g/ml or 30 ⁇ g/ml with respect to the final mixture, respectively.
  • the test tube containing this mixture was incubated for 18 hours in a shaking incubator at 37°C.
  • antibacterial activity was shown for the composition of the present invention using trehalose, but almost no antibacterial activity was shown in the composition of the control group using sucrose.
  • trehalose was suitable as a surfactant in the composition of the present invention.
  • composition of the present invention is a safe composition that can minimize skin irritation while exhibiting an antibacterial effect on acne-causing bacteria.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne des compositions pour le traitement de l'acné.
PCT/KR2021/008052 2020-06-26 2021-06-26 Composition pour le traitement de l'acné ou l'amélioration de la peau WO2021261971A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2020-0078644 2020-06-26
KR1020200078644A KR102170850B1 (ko) 2020-06-26 2020-06-26 여드름 치료 또는 피부개선용 조성물

Publications (1)

Publication Number Publication Date
WO2021261971A1 true WO2021261971A1 (fr) 2021-12-30

Family

ID=73397884

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2021/008052 WO2021261971A1 (fr) 2020-06-26 2021-06-26 Composition pour le traitement de l'acné ou l'amélioration de la peau

Country Status (2)

Country Link
KR (1) KR102170850B1 (fr)
WO (1) WO2021261971A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230171869A (ko) 2022-06-14 2023-12-21 이승창 여드름 예방 또는 치료용 약학 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080006568A (ko) * 2005-03-30 2008-01-16 레반스 테라퓨틱스, 아이엔씨. 여드름 치료용 조성물 및 방법
JP2011093835A (ja) * 2009-10-29 2011-05-12 Noevir Co Ltd 皮膚外用剤
KR20180017974A (ko) * 2016-08-12 2018-02-21 (주)한국융합기술연구소 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 치료용 화장료 조성물
KR20180137952A (ko) * 2017-06-20 2018-12-28 (주)지유본초 마스크 팩

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100491746B1 (ko) 1997-06-02 2005-09-02 주식회사 엘지생활건강 모황련추출물을함유하는여드름예방및치료용조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080006568A (ko) * 2005-03-30 2008-01-16 레반스 테라퓨틱스, 아이엔씨. 여드름 치료용 조성물 및 방법
JP2011093835A (ja) * 2009-10-29 2011-05-12 Noevir Co Ltd 皮膚外用剤
KR20180017974A (ko) * 2016-08-12 2018-02-21 (주)한국융합기술연구소 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 치료용 화장료 조성물
KR20180137952A (ko) * 2017-06-20 2018-12-28 (주)지유본초 마스크 팩

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JANG, MIN-WOO; HA, BAE-JIN: "Effects of Broccoli on Anti-inflammation and Anti-oxidation According to Extraction Solvent", JOURNAL OF FOOD HYGIENE AND SAFETY, vol. 27, no. 4, 31 December 2012 (2012-12-31), pages 461 - 465, XP009533192, ISSN: 1229-1153, DOI: 10.13103/JFHS.2012.27.4.461 *

Also Published As

Publication number Publication date
KR102170850B1 (ko) 2020-11-02

Similar Documents

Publication Publication Date Title
Jaiarj et al. Anticough and antimicrobial activities of Psidium guajava Linn. leaf extract
CN108904376B (zh) 一种具有控油祛痘功效的化妆品用中药复方发酵液及其制备与应用
gowdu Viswanathan et al. Antimicrobial activity of bioactive compounds and leaf extracts in Jatropha tanjorensis
CN104998153A (zh) 一种检验科用杀菌消毒液及制备方法
CN106619380A (zh) 一种祛痘精华液
CN111973515B (zh) 一种抑菌修复植物提取组合物、其制备方法及应用
WO2021261971A1 (fr) Composition pour le traitement de l'acné ou l'amélioration de la peau
KR20110128385A (ko) 미담 청결안을 이용한 여드름 개선을 위한 한방 조성물 및 제조방법
JPH0616530A (ja) 化粧料
CN113274455A (zh) 中药组合物及其应用
WO2009134021A2 (fr) Composition d’extraits de plante pour atténuer le prurit
Ekwenye et al. Antibacterial effect of Phyllanthus niruri (Chanca Piedra) on three enteropathogens in man
KR20110130184A (ko) 항 여드름 효능을 갖는 꾸지뽕나무 추출물과 이를 함유하는 화장료 조성물
CN107912463A (zh) 一种中西结合杀菌消毒液及制备方法
Islam et al. Antidiabetic, cytotoxic activities and phytochemical screening of Peltophorum pterocarpum (DC.) K. Heyne root
Luka et al. Phytochemical screening and in vitro evaluation of antibacterial activity of aqueous and ethanolic extracts of root and stem bark of Bridelia ferruginea. Benth.(Euphorbiaceae)
WO2018131780A1 (fr) Composition destinée à prévenir ou à traiter la gastrite ou l'ulcère gastroduodénal
Acheampong et al. Antioxidant and antimicrobial activity of the methanol and petroleum ether extracts of the stem of Microdesmis puberula
CN111803599B (zh) 一种祛痘外用中药组合物及其制剂
WO2022010035A1 (fr) Composition pharmaceutique anticancéreuse comprenant un extrait de plantes
EP2793917B1 (fr) Extrait de rhus copallina pour utilisation comme médicament
WO2013147409A1 (fr) Extrait naturel utilisé pour prévenir et traiter une affection buccale
Refdanita et al. Diabetic Wound Healing and Antimicrobial Activities of Gels Melastoma malabathricum L. and Psidium guajava L. in Sprague Dawley Rats
Akuodor et al. In vitro antimicrobial activity of leaf extract of Berlina grandiflora Hutch. and Dalz.
Velmurugan et al. Preliminary phytochemical screening and antibacterial activity of Phyllodium pulchellum L. Desv. An important medicinal plant

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21829140

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21829140

Country of ref document: EP

Kind code of ref document: A1