WO2021221149A1 - Composition d'émulsion huile dans eau - Google Patents

Composition d'émulsion huile dans eau Download PDF

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Publication number
WO2021221149A1
WO2021221149A1 PCT/JP2021/017143 JP2021017143W WO2021221149A1 WO 2021221149 A1 WO2021221149 A1 WO 2021221149A1 JP 2021017143 W JP2021017143 W JP 2021017143W WO 2021221149 A1 WO2021221149 A1 WO 2021221149A1
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Prior art keywords
oil
water emulsified
phase
oil phase
mass
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PCT/JP2021/017143
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English (en)
Japanese (ja)
Inventor
麻依 遠山
頌子 小河
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株式会社 資生堂
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Priority to CN202180026591.8A priority Critical patent/CN115379822B/zh
Priority to JP2022518143A priority patent/JPWO2021221149A1/ja
Publication of WO2021221149A1 publication Critical patent/WO2021221149A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone

Definitions

  • the present invention relates to an oil-in-water emulsified composition. More specifically, the present invention relates to an oil-in-water emulsified composition having both an immediate visual skin correction effect and a long-term wrinkle improving effect by simultaneously blending an effective amount of powder and vitamins A (retinols).
  • Vitamin A retinol
  • vitamin A retinol
  • retinol and its derivatives
  • vitamin A acts on keratinocytes to exert a hyaluronic acid synthesis promoting effect and exerts a wrinkle improving effect by increasing the water content of the stratum corneum.
  • vitamin As retinols
  • vitamin As are extremely unstable and have a problem that they are easily altered by the influence of heat, light, oxygen and the like.
  • Patent Document 1 describes an oil-in-water emulsified skin cosmetic containing vitamin A in combination with three types of nonionic surfactants and a higher alcohol having 14 to 24 carbon atoms.
  • the nonionic surfactant and higher alcohol form an ⁇ -gel structure together with oil in the presence of water, stabilizing not only emulsion stability but also vitamin As. It is said that it can be held in.
  • it is necessary to use all three types of specific nonionic surfactants, which narrows the range of formulations.
  • Patent Document 2 states that (A) one or more higher alcohols having a linear saturated alkyl chain; (B) a hydrophilic surfactant containing a nonionic surfactant; (C) an average particle size. By containing 4 to 30% by mass of a powder of 1 to 30 ⁇ m; and (D) water, an aqueous cosmetic composition capable of naturally correcting the appearance of the skin while being an aqueous base having a fresh feeling of use. The thing is disclosed.
  • Patent Document 3 describes (A) 1 to 20% by mass of hydrophobized titanium oxide having an average particle size of 0.1 ⁇ m or more; (B) a sugar ester having a carboxyl group in its structure; (C) a liquid higher fatty acid; The oil-in-water emulsified cosmetic containing (D) higher alcohol; (E) nonionic surfactant; (F) water and (G) oil has the effect of making the skin look beautiful and has emulsion stability. It is stated that it is excellent.
  • Patent Documents 1 to 3 by introducing an ⁇ -gel structure into the system, it has succeeded in stably maintaining vitamin A in Patent Document 1 and powder components in Patent Documents 2 and 3. However, it has been difficult to exert the respective effects while keeping both the vitamin A and the powder stable by simply combining Patent Document 1 with Patent Document 2 or 3.
  • the subject of the present invention is the effect of stably retaining vitamin A and powder components while utilizing the fresh feeling of use of the oil-in-water emulsified composition, the effect of immediately correcting the appearance of the skin, and wrinkles from a long-term perspective. It is an object of the present invention to provide an oil-in-water emulsified composition having an improving effect.
  • an oil-in-water emulsified composition containing a first oil phase containing powder and a second oil phase containing vitamin A containing a first oil phase containing powder and a second oil phase containing vitamin A.
  • the present invention is an oil-in-water emulsified composition in which an oil phase is dispersed in an aqueous phase, wherein the oil phase includes a first oil phase containing powder, vitamin A and / or a derivative thereof, and a polar oil.
  • an oil-in-water emulsified composition comprising a second oil phase containing.
  • the oil-in-water emulsified composition according to the present invention contains a powder component having a skin-correcting effect (unevenness-correcting effect) and vitamin A having a wrinkle-improving effect in separate oil phases, thereby mutually.
  • the action can be suppressed.
  • the oil-in-water emulsified cosmetic of the present invention is excellent in emulsification stability and can stably retain vitamin A having an effect of improving wrinkles for a long period of time and continuously exert its effect.
  • composition of the present invention includes an aqueous phase which is a continuous phase and a first oil phase and a second oil phase which are dispersed phases. It will be described in detail below.
  • the first oil phase in the composition of the present invention contains a powder and an oil component (also referred to as “first oil component”), and the powder is dispersed in the first oil component.
  • the powder to be blended in the first oil phase is a powder that can be blended in cosmetics, external preparations for skin, etc., and is not particularly limited as long as it exhibits a skin correction effect (unevenness correction effect), and may be an inorganic powder. It may be an organic powder.
  • the inorganic powder examples include titanium oxide, zinc oxide, talc, mica, sericite, kaolin, black iron oxide, yellow iron oxide, red iron oxide, carbon black, manganese violet, ultramarine blue, dark blue, chromium oxide, and the like.
  • examples thereof include chromium hydroxide, calcium silicate, magnesium silicate, zinc oxide, calcium carbonate, magnesium carbonate, magnesium silicate, barium sulfate, and pearl pigments (bengala-coated mica, titanium oxide-coated mica, etc.).
  • an ultraviolet scattering agent such as fine particle titanium oxide or fine particle zinc oxide having an average primary particle diameter of less than 100 ⁇ m.
  • the surface of the inorganic powder particles is preferably hydrophobized.
  • silicones such as methylhydrogenpolysiloxane and dimethylpolysiloxane, dextrin fatty acid ester, higher fatty acid, higher alcohol, fatty acid ester, metal soap, alkylphosphate ether, fluorine compound, or carbonization of squalane, paraffin and the like.
  • methods for hydrophobizing treatment with hydrogens and the like by a wet method using a solvent, a vapor phase method, a mechanochemical method, or the like can be exemplified.
  • the shape and size of the powder to be blended in the first oil phase are not particularly limited, but it is preferable to include the hydrophobic spherical powder in the blended powder because the skin correction effect is further improved.
  • the hydrophobic spherical powder include silicone powder, resin powder such as PMMA, silica powder and the like.
  • the amount of the powder to be blended in the first oil phase may be an amount that exerts a skin correction effect, and is usually 1% by mass or more, typically 3% by mass or more, based on the total amount of the composition.
  • the upper limit of the blending amount of the powder is not particularly limited, but can be, for example, 20% by mass or less, 15% by mass or less, or the like with respect to the total amount of the composition.
  • first oil As the oil contained in the first oil phase (also referred to as "first oil"), it is preferable to use a non-polar oil selected from hydrocarbon oil and silicone oil.
  • silicone oil include chain polysiloxane (for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxane (for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexane). Siloxane, etc.).
  • the amount of oil (first oil) to be blended in the first oil phase is usually 1 to 30% by mass, preferably 2 to 25% by mass, based on the total amount of the composition.
  • the silicone oil occupies at least 40% by mass or more of the oil component (first oil component) constituting the first oil phase.
  • the composition of the present invention includes, for example, an embodiment containing 50% by mass or more, 65% by mass or more, or 80% by mass or more of silicone oil of the first oil content. Alternatively, the entire first oil component may be used as silicone oil.
  • Dispersants include higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid, linolein. Acids, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the like can be mentioned.
  • EPA eicosapentaenoic acid
  • DHA docosahexaenoic acid
  • the first oil phase is preferably emulsified in the aqueous phase using a surfactant.
  • a surfactant for emulsifying the first oil phase (referred to as "first surfactant"), it has a silicone-based surfactant, particularly a silicone skeleton (polysiloxane structure), and has an HLB of less than 8. It is preferable to use the above-mentioned surfactant.
  • Silicone-based surfactants include, for example, polyoxyalkylene-modified silicones, polyoxyalkylene-alkyl co-modified silicones, polyglycerin-modified silicones, and / or polyglycerin-alkyl co-modified silicones.
  • silicone-based surfactant used as the first surfactant include bisbutyldimethicone polyglyceryl-3, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, and PEG-.
  • the first surfactant is preferably blended in an amount of 0.2 to 4% by mass based on the total amount of the composition.
  • the second oil phase contains vitamin A and / or its derivatives and oils.
  • the vitamin A fatty acid ester include retinol acetate, retinol palmitate, retinol propionate, and retinol linoleate.
  • the salt examples include alkali metal salts (eg, sodium salt, potassium salt, lithium salt, etc.), alkaline earth metal salts (eg, calcium salt, magnesium salt, etc.), ammonium salts, organic amine salts (eg, monoethanolamine salt, etc.). , Diethanolamine salt, triethanolamine salt, etc.) and the like are exemplified.
  • vitamin A retinol
  • As the vitamin A and / or its derivative one kind or two or more kinds can be used.
  • the blending amount of vitamin A and / or its derivative in the composition of the present invention is at least 0.01% by mass, preferably 0.05% by mass, based on the total amount of the composition. If the blending amount is less than 0.01% by mass, it is difficult to sufficiently exert the wrinkle improving effect. On the other hand, since a relatively large amount of vitamin A and / or a derivative thereof can be stably blended in the composition of the present invention, the upper limit of the blending amount is not particularly limited. For example, an upper limit value such as 10% by mass or less, 5% by mass or less, or 4% by mass or less can be set. That is, in the composition of the present invention, for example, a blending amount range of vitamin A and / or a derivative thereof such as 0.01 to 4% by mass or 0.05 to 5% by mass can be selected without limitation.
  • the oil component to be blended in the second oil phase may contain polar oil as an essential component and may contain other oil components that can be blended in cosmetics and external preparations for skin. ..
  • the polar oil is preferably selected from ester oils and UV absorbers. Examples of other oils include natural fats and oils, waxes and the like.
  • ester oil examples include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyl octanate, and cetyl lactate.
  • Myristyl Lactate Lanolin Acetate, Isocetyl Stearate, Isocetyl Isostearate, Cholesteryl 12-Hydroxystearate, Ethylene Glycol Di-2-ethylhexanoate, Dipentaerythritol Fatty Acid Ester, N-alkyl Glycol Monoisostearate, Neopentyl Glycol Dicaprate , Diisostearyl malate, Glycerin di-2-heptylundecanoate, Trimethylolpropane tri-2-ethylhexanoate, Trimethylolpropane triisostearate, Pentaerislit tetra-2-ethylhexanoate, Tri-2-ethyl Glycerin hexanoate, glycerin trioctanoate, glycerin triisopalmitate, cetyl 2-ethylhexanoate, 2-ethylhex
  • an oil-soluble ultraviolet absorber can be blended in place of the above ester oil or in addition to the ester oil.
  • the oil-soluble UV absorber those that can be usually used for cosmetics and external skin preparations can be used.
  • triazine-based UV absorbers benzoic acid-based UV absorbers, anthranilic acid-based UV absorbers, and salicylic acid. Examples thereof include UV absorbers, silicic acid UV absorbers, and benzophenone UV absorbers.
  • 2-ethylhexyl paramethoxycinnamate which is an ultraviolet absorber that is liquid at room temperature, is preferably used.
  • the blending amount of the oil component (second oil component) in the second oil phase is 5 to 40% by mass with respect to the total amount of the composition.
  • the second oil preferably contains polar oil.
  • the blending amount of the polar oil is preferably 1 to 35% by mass, more preferably 10 to 30% by mass, based on the total amount of the composition.
  • the ratio (mass%) of the polar oil to the total amount of the second oil phase is preferably 15% by mass or more, more preferably 30% by mass or more, and further preferably 45% by mass or more.
  • the polar oil preferably contains an ester oil, and the ratio (mass%) of the ester oil to the total amount of the polar oil is preferably 50% by mass or more, more preferably 60% by mass or more. be.
  • the second oil phase preferably contains a higher alcohol and / or a higher fatty acid (hereinafter also referred to as “higher alcohol or the like”) and a surfactant (referred to as “second surfactant").
  • Examples of the higher alcohol to be blended in the second oil phase include dodecanol (lauryl alcohol), tridodecanol, tetradodecanol (myristyl alcohol), pentadecanol, hexadecanol (cetyl alcohol), heptadecanol, and the like.
  • Octadecanol (stearyl alcohol), nonadecanol, icosanol (araquil alcohol), henicosanol, docosanol (behenyl alcohol), tricosanol, tetracosanol (carnavir alcohol), pentacosanol, hexacosanol (ceryl alcohol), bacil alcohol, Elysyl alcohol and the like can be mentioned.
  • the higher alcohol etc.
  • one or more of the above can be used.
  • the combination is such that the melting point of the mixture is 60 ° C. or higher. If this melting point is less than 60 ° C., the temperature stability of the system may decrease depending on the formulation.
  • a combination of stearyl alcohol, behenyl alcohol and batyl alcohol is particularly preferable.
  • the blending amount of the higher alcohol or the like in the cosmetic composition of the present invention is not particularly limited, but is 0.3 to 10% by mass, preferably 0.5 to 9% by mass.
  • a nonionic surfactant is preferable.
  • Specific examples include glycerin monostearyl ether, POE (20) cetyl ether, POE (30) cetyl ether, POE (20) stearyl ether, POE (25) stearyl ether, POE (30) stearyl ether, POE (20) behenyl.
  • POE (20) cetyl ether, POE (30) cetyl ether, POE (20) stearyl ether, POE (30) stearyl ether, POE (30) behenyl ether and the like can be mentioned.
  • POE is an abbreviation for polyoxyethylene.
  • the blending amount of the second surfactant is preferably 0.3 to 10% by mass, more preferably 0.5 to 5% by mass, based on the total amount of the composition.
  • the higher alcohol or the like By blending a higher alcohol or the like and a second surfactant in the second oil phase, the higher alcohol or the like forms an aggregate composed of a lamellar bilayer film together with the second surfactant in the presence of water.
  • the higher alcohol or the like can take a so-called ⁇ -gel structure and contributes to the stabilization of the system.
  • composition of the present invention is described in Patent Document 1 because it is stabilized by blending powder in the first oil phase and blending a polar oil such as an ultraviolet absorber in the second oil phase. It is not necessary to use a combination of three specific surfactants as described above. Therefore, the composition of the present invention does not contain any one or more of sorbitan tristearate, polyethylene glycol stearate having an addition molar number of 20 to 120, and glyceryl stearate having an HLB of 5 to 8. Includes aspects.
  • the composition of the present invention is an oil-in-water emulsified composition in which the above-mentioned first oil phase and second oil phase are dispersed in an aqueous phase.
  • the aqueous phase which is a continuous phase in the emulsified composition of the present invention, contains water and optionally contains an aqueous component.
  • Aqueous components are components that are soluble or compatible with water.
  • a surfactant By blending a surfactant (referred to as “third surfactant”) in the aqueous phase, the stability of the emulsification system is further improved.
  • the third surfactant it is preferable to select a nonionic hydrophilic surfactant having a relatively bulky molecular structure.
  • polyoxyethylene hydrogenated castor oil (10EO), polyoxyethylene hydrogenated castor oil (20EO), polyoxyethylene hydrogenated castor oil (30EO), polyoxyethylene hydrogenated Poly such as castor oil (40EO), polyoxyethylene hydrogenated castor oil (50EO), polyoxyethylene hydrogenated castor oil (60EO), polyoxyethylene hydrogenated castor oil (100EO), etc.
  • At least one nonionic selected from the group consisting of oxyethylene hydrogenated castor oil, polyoxyethylene glyceryl stearate, polyoxyethylene glyceryl isostearate, polyoxyethylene glyceryl triisostearate, and polyoxyethylene hydrogenated castor oil succinic acid.
  • a surfactant is preferably used.
  • the blending amount of the third surfactant in the composition of the present invention is preferably 0.3 to 10% by mass, preferably in the range of 0.5 to 9% by mass, based on the total amount of the composition. More preferred.
  • a thickener to the aqueous phase because the emulsification stability can be further improved by suppressing the sedimentation and creaming of the emulsified oil droplets and the aggregation of the powder over time.
  • the thickener to be blended in the aqueous phase is not particularly limited as long as it is an aqueous phase thickener that can be used in cosmetics and quasi-drugs.
  • xanthan gum cellulose (carboxymethyl cellulose (salt), etc.), Arabic gum, carrageenan, pectin, canten, quince seed (malmero) extract, starch, algae colloid (brown algae extract), mucopolysaccharide, white jellyfish polysaccharide, succinoglycan.
  • Plant-based polymers such as dextran and purulan, animal-based polymers such as collagen, casein and gelatin, starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, (Na acrylate, acryloyl).
  • starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, (Na acrylate, acryloyl).
  • acrylic acid-based polymers such as dimethyl taurine Na) copolymers, (dimethyl acrylamide / acryloyl dimethyl taurine Na) cross polymers, and copolymers containing 2-acrylamide-2-methylpropansulfonic acid.
  • the amount of the thickener to be blended is preferably 0.1 to 6% by mass with respect to the total amount of the composition.
  • the silicone elastomer powder When the silicone elastomer powder is blended with the composition of the present invention, stickiness can be suppressed and the usability of the composition can be further improved.
  • a spherical powder of a silicone elastomer particularly a white spherical silicone composite powder in which a spherical silicone rubber powder is coated with a silicone resin.
  • the average particle size of the silicone elastomer spherical powder is preferably 0.1 to 100 ⁇ m, more preferably 1 to 50 ⁇ m, and the JIS-A hardness is preferably in the range of 10 to 80.
  • silicone elastomer powder examples include (vinyldimethicone / methicone silsesquioxane) crosspolymer, (diphenyldimethicone / vinyldiphenyldimethicone / silsesquioxane) crosspolymer, and polysilicone-in the cosmetic ingredient labeling name.
  • One or more selected from 1 cross polymer, polysilicone-22, (dimethicone / vinyldimethicone / methicone) cross polymer and the like are preferably used.
  • the blending amount of the silicone elastomer powder is preferably 1 to 10% by mass, more preferably 2 to 8% by mass.
  • the silicone elastomer powder may be blended in either the oil phase or the aqueous phase, but is preferably blended in the aqueous phase.
  • composition of the present invention can be added with various ingredients widely used in cosmetics and quasi-drugs as long as the effects of the present invention are not impaired.
  • water-soluble active substances or stabilizers such as vitamin B group, vitamin C and its derivatives, potassium 4-methoxysalicylate, tranexamic acid, pantothenic acid and its derivatives, vitamins such as biotin, moisturizers, vitamin E, arginine.
  • the method for producing the composition of the present invention is not particularly limited, but for example, an oil-in-water emulsion (referred to as "first emulsion") in which the first oil phase component is dispersed in a part of the aqueous phase is prepared. Then, an oil-in-water emulsion (referred to as “second emulsion”) in which the second oil phase component is dispersed in the remaining aqueous phase is separately prepared, and then the first emulsion and the second emulsion are prepared. Can be manufactured by mixing with. Alternatively, it can also be produced by preparing a first emulsion in which the first oil phase component is dispersed in an aqueous phase, and then adding a second oil phase component to the first emulsion and emulsifying it.
  • first emulsion oil-in-water emulsion
  • second emulsion oil-in-water emulsion
  • it can also be produced by preparing a first emulsion in which the first oil phase component
  • composition of the present invention not only exerts a skin-correcting effect immediately after application while having a fresh feel peculiar to an oil-in-water emulsion, but also has a long-term wrinkle improving effect due to the blended vitamin As. Demonstrate over.
  • the present invention provides an oil-in-water emulsified cosmetic, particularly a skin cosmetic, comprising the composition of the present invention described above.
  • the form of the oil-in-water emulsified cosmetic of the present invention is not particularly limited, and can be provided in various forms such as cream, milky lotion, or gel.
  • An oil-in-water emulsified composition was prepared according to the formulations listed in Tables 1 and 2 below.
  • the composition of each example was produced as follows. (1) Prepare an aqueous phase. (2) A first oil phase (oil phase 1) that has been subjected to a dispersion treatment is prepared. (3) The first oil phase is mixed with the aqueous phase to prepare a first emulsion. (4) The second oil phase component (oil phase 2) is heated and mixed to prepare a second oil phase. (5) The second oil phase is mixed with the first emulsion and cooled to room temperature.
  • ⁇ Skin correction effect> The composition of each example (immediately after production) was applied to the face by a specialized panel (10 people), and the actual feeling of the effect was evaluated for the skin correction effect after application according to the following criteria.
  • D 3 or less evaluated that "there is a real feeling of effect”.
  • ⁇ Wrinkle improvement effect> The compositions of each example were shielded from light with aluminum foil and stored at 50 ° C. for 1 month.
  • the amount of vitamin A in the composition after 1 month (50 ° C.) was analyzed by high performance liquid chromatography, and the residual ratio (%) with respect to the amount of vitamin A immediately after production was calculated. The higher the residual rate, the more the activity of vitamin A is maintained and the effect of improving wrinkles is exhibited.
  • the conditions of high performance liquid chromatography used are as follows. Column: C18 column (manufactured by Shiseido Co., Ltd.) Detection: UV310nm Mobile phase: 72% ethanol / 10% acetonitrile / 17.5% ion-exchanged water / 0.5% acetic acid
  • Residual rate is 90% or more
  • B Residual rate is 80% or more and less than 90%
  • C Residual rate is 60% or more and less than 80%
  • D Residual rate is less than 60%
  • the compositions of the present invention in which the powder was blended in the first oil phase and vitamin A was blended in the second oil phase had emulsion stability. Good results were obtained in all of the skin correction effect and the wrinkle improvement effect. These good results show that the amount of vitamin A in the second oil phase is increased (implementation) regardless of the type and amount of the thickener to be blended in the aqueous phase, or the presence or absence of the silicone elastomer powder (Examples 1 to 3). It does not depend on Example 4) or the type of oil in the first oil phase (Example 5).
  • Example 6 when the ratio of the polar oil in the second oil phase was lowered, the wrinkle improving effect was slightly reduced, but there was no problem in practical use (Example 6).
  • the composition of Example 6 was separated under severe conditions of storage at 50 ° C. for 1 month, but was stable for more than 1 month when stored at the actual operating temperature (room temperature).
  • the skin correction effect was not obtained in Comparative Example 1 in which the powder was not blended with respect to these Examples.
  • Comparative Example 2 in which the powder and vitamin A were blended in the same oil phase, vitamin A could not be stably retained, and a sufficient wrinkle improving effect could not be obtained.

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Abstract

Le problème décrit par la présente invention est de fournir une composition d'émulsion huile dans eau qui maintient de manière stable la vitamine A et analogues et des composants pulvérulents tout en utilisant la sensation hydratante inhérente aux compositions d'émulsion huile dans eau, et qui a à la fois l'effet de corriger instantanément l'aspect de la peau et l'effet d'amélioration des rides sur le long terme. La solution selon l'invention porte sur une composition d'émulsion huile dans eau dans laquelle une phase huileuse est dispersée dans une phase aqueuse, et qui est caractérisée en ce que la phase huileuse inclut une première phase huileuse contenant une poudre, et une seconde phase huileuse contenant une huile polaire et de la vitamine A et/ou un dérivé de celle-ci.
PCT/JP2021/017143 2020-05-01 2021-04-30 Composition d'émulsion huile dans eau WO2021221149A1 (fr)

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CN202180026591.8A CN115379822B (zh) 2020-05-01 2021-04-30 水包油型乳化组合物
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11244688A (ja) * 1998-02-27 1999-09-14 Shiseido Co Ltd 水中油型乳化組成物
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