WO2021218972A1 - 采样/施药胶囊 - Google Patents

采样/施药胶囊 Download PDF

Info

Publication number
WO2021218972A1
WO2021218972A1 PCT/CN2021/090280 CN2021090280W WO2021218972A1 WO 2021218972 A1 WO2021218972 A1 WO 2021218972A1 CN 2021090280 W CN2021090280 W CN 2021090280W WO 2021218972 A1 WO2021218972 A1 WO 2021218972A1
Authority
WO
WIPO (PCT)
Prior art keywords
storage cavity
sampling
temporary storage
medicating
housing
Prior art date
Application number
PCT/CN2021/090280
Other languages
English (en)
French (fr)
Inventor
杨戴天杙
包宇晖
彭航宇
明繁华
Original Assignee
安翰科技(武汉)股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 安翰科技(武汉)股份有限公司 filed Critical 安翰科技(武汉)股份有限公司
Priority to US17/922,496 priority Critical patent/US20230263509A1/en
Publication of WO2021218972A1 publication Critical patent/WO2021218972A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/045—Control thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6861—Capsules, e.g. for swallowing or implanting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions

Definitions

  • the invention relates to the technical field of medical devices, and in particular to a sampling/medicating capsule capable of sampling and administering multiple times.
  • the existing digestive tract sample acquisition device passively samples, and its sampling rate and sampling volume are difficult to estimate: if the sampling time is too long, it may cause large changes in the sampling area and low positioning accuracy. If the sampling time is too short, it may cause Insufficient sample size.
  • the purpose of the present invention is to provide a sampling/medicating capsule capable of sampling and administering multiple times.
  • a sampling/medicating capsule which is characterized in that it comprises:
  • the outer shell includes a first shell and a second shell. At least part of the first shell includes a support body with a plurality of first openings, a liquid-proof and air-permeable body located in the support body and at the first openings membrane;
  • the sampling/medicating assembly includes a storage cavity formed at least partially surrounded by the liquid-proof and gas-permeable membrane, a temporary storage cavity located in the housing, and a connection between the outside of the sampling/medicating capsule and the temporary storage cavity
  • the first one-way element, the second one-way element connecting the temporary storage cavity and the storage cavity, the pump that changes the pressure in the temporary storage cavity, the first one-way element and the second one-way element Lead to the same
  • the control module includes a microprocessor connected in communication with the pump.
  • the area of the first opening is between 0.8 mm 2 and 3 mm 2 .
  • first one-way element and the second one-way element are respectively selected from a one-way valve or a one-way membrane.
  • the pump includes a diaphragm communicating with the temporary storage cavity, and a deformation element that repeatedly drives at least part of the diaphragm to deform to change the pressure in the temporary storage cavity.
  • the deformation element is at least one of a piezoelectric micropump based on a piezoelectric material, a micropump based on a metal with a dual thermal deformation coefficient, and a micropump based on a shape memory alloy.
  • the forward conduction pressure threshold of the first unidirectional element and the second unidirectional element is 5kPa-15kPa, and the reverse withstand pressure threshold is 50kPa-100kPa; the suction force of the pump is between 20kPa-30kPa, and the thrust is medium In 30kPa ⁇ 50kPa.
  • the sampling/medicating capsule further includes a partition wall arranged in the outer shell and located at the junction of the first shell and the second shell, and arranged on the partition wall facing the second shell.
  • a partition wall on one side of the housing, the partition wall and the first housing are surrounded to form the storage cavity, and the partition wall, the partition wall and the structure between the two are jointly surrounded and formed The temporary storage cavity;
  • the second housing has a passage communicating with the temporary storage cavity, the first one-way element is disposed on the passage;
  • the partition wall has a second opening, so The second unidirectional element is fixed at the second opening.
  • first opening is located on a part of the first housing adjacent to the partition wall
  • channel is located on a part of the second housing adjacent to the partition wall
  • the channel includes a plurality of sample holes opened on the second housing, and a sample cavity communicating with the plurality of sample holes; the first unidirectional element communicates the sample cavity with the temporary storage Cavity.
  • each sample hole is smaller than the pore size of the first unidirectional element communicating with the sample cavity, and/or the sample cavity has a filtering structure.
  • Figure 1 is a cross-sectional view of a sampling/medicating capsule of a preferred embodiment of the present invention cut along the axial direction;
  • FIG. 2 is a schematic diagram of the working state of the sampling/medicating capsule shown in FIG. 1 when the digestive tract fluid enters the temporary storage cavity;
  • Fig. 3 is a schematic diagram of the working state of the digestive tract fluid of the sampling/medicating capsule shown in Fig. 1 entering the storage cavity from the temporary storage cavity;
  • FIG. 4 is a cross-sectional view taken along the axial direction of the sampling/medicating capsule of another preferred embodiment of the present invention.
  • Figure 5 is a plan view of the first housing in Figures 1 to 4;
  • Fig. 6 is a cross-sectional view of the first housing in Figs. 1 to 4.
  • FIG. 1 to FIG. 6 is a sampling/medicating capsule 100 according to a preferred embodiment of the present invention, which includes a housing 1, a sampling/medicating component 2, and a control module 3.
  • the control module 3 includes a microprocessor communicatively connected with at least part of the structure in the sampling/medicating assembly 2 to control its working state.
  • the housing 1 is biocompatible and will not be corroded by digestive juices, and can be set to be transparent or opaque as required; specifically, the housing 1 includes a first housing 11 and a second housing 12.
  • At least part of the first housing 11 includes a support body 111 having a plurality of first openings, and a liquid repellent located in the support body 111 and located at the first openings. ⁇ 112 ⁇ Breathable film 112.
  • all of the first housing 11 includes a support 111 and a liquid-proof and gas-permeable membrane 112.
  • the density of the first openings provided on the supporting body 111 is not limited, the supporting body 111 may only include a few of the first openings, and the supporting body 111 may also be the first opening.
  • the first opening may also be referred to as a grid hole in this case.
  • the shape of the first opening is not limited, and may be a round hole, a square hole or other irregular holes.
  • the diameter of the first opening or grid hole is between 10 mesh and 18 mesh, or the diameter is 1 mm to 2 mm, or the area of the hole is 0.8 mm 2 ⁇ 3mm 2 .
  • the liquid-proof and gas-permeable membrane 112 has good gas permeability, but has good resistance to liquids. Therefore, air can freely enter and exit the housing 1 through the first housing 11, while the digestive tract fluid cannot Pass freely.
  • the waterproof grade of the liquid-proof and breathable membrane 112 is IPX8.
  • the sampling/medicating assembly 2 includes a storage cavity 24 formed at least partially surrounded by the liquid-proof and gas-permeable membrane 112, a temporary storage cavity 22 located in the housing 1, and communicating with the sampling/medicating capsule
  • the directions of the first unidirectional element 21 and the second unidirectional element 23 are the same.
  • the storage cavity 24 can communicate with the outside of the sampling/medicating capsule 100 through the liquid-proof and gas-permeable membrane 112.
  • the pump 26 is an electronic control element, and is connected to the microprocessor in communication.
  • the first unidirectional element 21 and the second unidirectional element 23 have the same access direction refers to the same flow direction for sampling samples or drugs.
  • the first one-way element 21 leads to the temporary storage cavity 22, and the second one-way element 23 leads to the storage cavity 24.
  • the sampling function can be realized; or, the The second one-way element 23 leads to the temporary storage cavity 22, and the first one-way element 21 leads to the outside of the sampling/medicating capsule 100.
  • the medicine application function can be realized.
  • the sampling/medicating capsule 100 integrates sampling and medicine application functions, and can be used as a sampling capsule or a medicine application capsule.
  • the storage cavity 24 is empty and is used to store samples taken at a specific part of the digestive tract.
  • the medicine is applied as a medicine capsule, the storage cavity 24 is filled with medicine to be released, mostly liquid medicine, and the medicine is released when the sampling/medicine capsule 100 reaches a specific part of the digestive tract.
  • the sampling/medicating capsule 100 further includes a sample/medicine capsule 100 disposed in the housing 1 and located at the junction of the first housing 11 and the second housing 12
  • the partition wall 13 is surrounded by the partition wall 13 and the first housing 11 to form the storage cavity 24.
  • the partition wall 13 is located at the junction of the first housing 11 and the second housing 12 and divides the interior of the first housing 11 and the second housing 12 into two spaces, specifically including:
  • the partition wall 13 is located at the end of the first housing 11 facing the second housing 12; or, the partition wall 13 is located between the first housing 11 and the second housing 12; Or, as shown in FIG. 1, the partition wall 13 is located at the end of the second housing 12 facing the first housing 11.
  • the sampling/medicating capsule 100 further includes a partition wall 14 arranged on the side of the partition wall 13 facing the second housing 12, and the partition wall 13, the partition wall 14 and the partition wall 14 are located therebetween.
  • the structures of the two surround the temporary storage cavity 22 together.
  • the temporary storage cavity 22 is enclosed by the partition wall 13, the partition wall 14, and the second housing 12 located in between or a structure attached to the second housing 12. Set formation.
  • the first one-way element 21 is fixed on the second housing 12 and communicates with the outside of the housing 1 and the temporary storage cavity 22.
  • the second one-way element 23 is fixed on the partition wall 13 and communicates with the temporary storage cavity 22 and the storage cavity 24.
  • the second unidirectional element 23 is fixed at the middle position of the partition wall 13 so that the sample/medicine can pass smoothly.
  • the first one-way element 21 and the second one-way element 23 are respectively selected from a one-way valve or a one-way membrane.
  • the one-way valve only allows the digestive juice and gas to pass through in one direction, and can withstand a pressure of 50kPa ⁇ 100kPa without infiltration. Place; For example, the one-way valve is sealed in the opening.
  • the unidirectional membrane also allows only one-way passage, and the installation method is to open a hole at a corresponding position, and the unidirectional membrane shields the opening.
  • the second housing 12 located between the partition wall 13 and the partition wall 14 has a channel, and the first unidirectional element 21 is arranged on the channel to control the unidirectional sample or medicine.
  • the partition wall 13 has a second opening, and the second unidirectional element 23 is fixed at the second opening; for example, the second unidirectional element 23 is fixed in the second opening.
  • the first opening is located on a part of the first housing 11 adjacent to the partition wall 13, and the channel is located on a part of the second housing adjacent to the partition wall 13
  • the distance between the first opening and the passage is relatively close at this time, and there is only a partition wall 13 in the middle, which can maintain the pressure difference of each cavity of the system within an acceptable range without causing the pump 26 to fail.
  • the load is too high and it fails.
  • the channel includes a plurality of sample holes 27 opened on the housing 1, and a sample cavity 28 communicating with the plurality of sample holes 27, and the first unidirectional element 21 communicates the sample cavity 28 with the sample cavity 28. Mentioned temporary storage cavity 22.
  • the sample hole 27 is a sampling hole 27, which can serve Anti-blocking effect.
  • each sample hole 27 is smaller than the hole diameter of the first unidirectional element 21 communicating with the sample cavity 28. Therefore, the material that can enter the sample cavity 28 through the sample hole 27 will not The temporary storage cavity 22 is blocked.
  • the sample cavity 28 has a filtering structure (not shown), such as but not limited to a filter, to prevent food residue from clogging the temporary storage cavity 22.
  • a filtering structure such as but not limited to a filter, to prevent food residue from clogging the temporary storage cavity 22.
  • a filtering structure please refer to Patent Invention No. 201811330328.4 "Digestive Juice” The structure design of anti-clogging and anti-inhalation of air in the sampling capsule system".
  • each sample hole 27 is smaller than the pore size of the first one-way element 21 communicating with the sample cavity 28, a filtering structure can also be provided in the sample cavity 28 to achieve double blocking prevention. Effect.
  • the plurality of sample holes 27 are distributed at intervals along the length direction or the circumferential direction of the sampling/applying capsule 100, which can ensure smooth sampling/applying.
  • the second one-way element 23 leads to the temporary storage cavity 22
  • the first one-way element 21 leads to the outside of the sampling/medicating capsule 100. Based on this direction, when applying medicine, the medicine enters the temporary storage cavity 22 from the storage cavity 24, and then enters the sample cavity 28 from the temporary storage cavity 22 and is thoroughly mixed, and then passes through a plurality of sample holes 27 Released to the digestive tract, expanding the scope of application.
  • the pressure in the storage cavity 24 is set to P0, the pressure in the temporary storage cavity 22 is P1, and the external environment pressure is set to P2.
  • ⁇ P is the forward conduction pressure threshold of the first unidirectional element 21 and the second unidirectional element 23.
  • the entire first housing 11 outside the storage cavity 24 is a porous structure such as a grid structure, and the liquid-proof and gas-permeable membrane 112 is covered inside, there is only one minute interval between the sample hole 27 and the first housing 11.
  • the thickness of the partition wall 13 is about 1 mm. Therefore, the sample hole 27 and some of the first openings on the first housing 11 are basically in the same space. If the environmental pressure of the local space changes due to peristalsis or the like, the pressure in the storage cavity 24 will change synchronously.
  • the external environmental pressure increases, that is, P2>P0, and P2>P1+ ⁇ P
  • the external air and liquid will enter the temporary storage cavity 22 through the first unidirectional element 21, and the pressure of the temporary storage cavity 22 will gradually increase.
  • the pressure in the temporary storage cavity 22 reaches P2- ⁇ P
  • the external pressure is not enough to push the first one-way element 21 away, and the gas and liquid stop flowing inward.
  • the internal gas and liquid cannot push the second one-way element 23 into the storage cavity 24.
  • the gas and liquid in the temporary storage cavity 22 will enter the storage cavity 24 until the pressure in the temporary storage cavity 22 decreases to P2+ ⁇ Stop after P. At this time, outside air and liquid cannot enter the temporary storage cavity 22 through the first unidirectional element 21.
  • the pressure in the temporary storage cavity 22 can always be maintained within ⁇ P of the environmental pressure.
  • the pressure in the storage cavity 24 can be kept consistent with the pressure of the environment outside the liquid-proof and gas-permeable membrane 112 (sample hole 27). Because the suction and thrust of the pump 26 are both higher than ⁇ P, it will not cause the throughput of the micro pump to fail, that is, it will not be unable to operate due to excessive load.
  • the pump 26 is used to change the pressure in the temporary storage cavity 22, cooperate with the directions of the first one-way element 21, the second one-way element 23, and the liquid-proof gas-permeable membrane 112 to complete sampling or application.
  • the first one-way element 21 leads to the temporary storage cavity 22, and the second one-way element 23 leads to the storage cavity 24 for digestion.
  • the flow direction of the tract fluid is: sequentially through the first one-way element 21, the temporary storage cavity 22, the second one-way element 23, and the storage cavity 24. In this process, it is mixed in the digestive tract.
  • the gas in the liquid passes through the liquid-proof and gas-permeable membrane 112 and is discharged to the outside of the housing 1.
  • the sampling process is specifically as follows: Please refer to 2, the pump 26 reduces the pressure of the temporary storage cavity 22, and the digestive juice of the digestive tract passes through the first unidirectional element 21 under the action of the internal and external pressure difference to enter the Temporary storage cavity 22; then referring to FIG. 3, the pump 26 increases the pressure in the temporary storage cavity 22, and the digestive juice enters the storage cavity 24 through the second one-way element 23 to complete sampling.
  • the second one-way element 23 leads to the temporary storage cavity 22, and the first one-way element 21 leads to the outside of the sampling/medicating capsule 100,
  • part of the air in the digestive tract enters the storage cavity 24 through the liquid-proof and gas-permeable membrane 112 to increase its pressure, so that the medicines stored in it can pass through the second unidirectional
  • the element 23 enters the temporary storage cavity 22 and then flows out into the digestive tract through the first one-way element 21.
  • the specific application process is as follows: the pump 26 reduces the pressure of the temporary storage chamber 22, and the gas/medicine in the storage chamber 24 enters the temporary storage chamber 22 through the second unidirectional element 23 so that the The pressure in the storage cavity 24 is reduced, and gas from the digestive tract passes through the liquid-proof and gas-permeable membrane 112 under the action of the internal and external pressure difference to enter the storage cavity 24, pushing the medicine through the second one-way element 23 to enter The temporary storage cavity 22; then, the pump 26 increases the pressure in the temporary storage cavity 22, and the medicine is discharged out of the sampling/medicating capsule 100 through the first unidirectional element 21.
  • the suction and thrust of the pump 26 are not less than the forward conduction pressure of the first one-way element 21 and the second one-way element 23, and neither is greater than The first unidirectional element 21 and the second unidirectional element 23 bear pressure in the opposite direction.
  • the forward conduction pressure threshold of the first unidirectional element 21 and the second unidirectional element 23 is 5 kPa to 15 kPa, and the reverse pressure threshold is 50 kPa to 100 kPa; the suction force of the pump 26 is between 20kPa ⁇ 30kPa, thrust is between 30kPa ⁇ 50kPa.
  • the pump 26 includes a diaphragm 261 communicating with the temporary storage cavity 22, and a deformation element 262 that repeatedly drives at least part of the diaphragm 261 to deform to change the pressure in the temporary storage cavity 22.
  • the diaphragm 261 is disposed on the partition wall 14, or the partition wall 14 is the diaphragm 261 as a whole. When the diaphragm 261 is deformed, the volume of the temporary storage cavity 22 changes, and the pressure Changes.
  • the deformation element 262 is a piezoelectric micropump based on a piezoelectric material.
  • the piezoelectric material will bend, driving the diaphragm 261 to bend to increase or decrease The pressure in the temporary storage cavity 22 is reduced.
  • the temporary storage cavity 22 then, the applied voltage is eliminated, and the piezoelectric material returns to its original shape to drive the diaphragm 261 back to its original shape, or a reverse voltage is applied, and the piezoelectric material bends toward the storage cavity 24 to drive the
  • the diaphragm 261 is bent toward the storage cavity 24 to reduce the volume of the temporary storage cavity 22, and the pressure in the temporary storage cavity 22 increases, so that the digestive juice enters the storage through the second one-way element 23 In the cavity 24, sampling is completed.
  • the deformation element 262 is a bimetallic micropump based on a metal with dual thermal deformation coefficients.
  • the bimetallic micropump is composed of two relatively fixed metal diaphragms. Since the deformation coefficients of the two metal diaphragms are different when heated, When heating elements such as resistors are used to heat them, they will deform to different degrees. Therefore, the bimetallic micropump can be deformed and drive the diaphragm 261 to deform, thereby changing the pressure of the temporary storage cavity 22.
  • the bimetallic micropump bends back to the storage cavity 24, thereby driving the diaphragm 261 to bend back to the storage cavity 24, reducing the temporary storage cavity 22 Pressure; stop heating, after the temperature is restored, the shape of the bimetallic micropump is restored, the shape of the diaphragm 261 is restored, and the pressure in the temporary storage cavity 22 increases.
  • the deformation element 262 is a micropump based on a shape memory alloy.
  • the shape memory alloy-based micropump is made of shape memory alloy. When a heating element is used to increase the temperature to a certain temperature, the shape memory alloy will deform and drive the diaphragm 261 to deform, thereby changing the temporary storage The pressure of the cavity 22.
  • the shape memory alloy-based micropump bends back to the storage cavity 24, thereby driving the diaphragm 261 to bend back to the storage cavity 24, reducing the temporary storage
  • the pressure of the cavity 22 after the heating is stopped, and the temperature is restored, the shape of the shape memory alloy-based micropump is restored, the shape of the diaphragm 261 is restored, and the pressure in the temporary storage cavity 22 increases.
  • the pressure of the temporary storage cavity 22 will repeatedly It becomes smaller and then larger, and can be sampled multiple times, avoiding the various drawbacks of single sampling.
  • the pump 26 includes a pneumatic pump 26 capable of repeatedly pumping and sending air to the temporary storage cavity 22, and an air storage structure communicating with the pneumatic pump 26.
  • the pneumatic pump 26 changes the temporary storage cavity 22 by pumping the gas in the temporary storage cavity 22 into the gas storage structure, or pumping the gas in the gas storage structure into the temporary storage cavity 22 At the same time, it controls the flow of the sample.
  • the volume of the gas storage structure is set such that when the gas circulates in the temporary storage cavity 22 and the gas storage structure, a sufficient pressure difference can be generated to meet the requirements of sampling or administration.
  • the sampling/medicating assembly 2 further includes a third opening provided on the first housing 11, a rubber stopper 25 located at the third opening, for example, the rubber stopper 25
  • the fit fit is installed in the third opening, which not only facilitates the injection of medicine into the storage cavity 24, but also facilitates the recovery of the sample by piercing the rubber stopper 25 through a syringe or the like after sampling.
  • sampling or drug application can be performed.
  • the control module 3 also includes a sensor 31 for collecting physiological parameters and/or image information in the digestive tract, and the sensor 31 is in communication with the microprocessor.
  • the sensor 31 is at least one of an image sensor, a pH sensor, or an ultrasonic sensor; when the sensor 31 includes an image sensor, part of the housing 1 is transparent; when the sensor 31 includes a pH sensor, the The housing 1 has a window. According to the picture acquired by the sensor 31 and the pH value, it is judged which part of the digestive tract the sampling/medicating capsule is located.
  • the specific judgment method can be any method in the prior art, and will not be repeated here.
  • control module 3 includes the sensor 31 and a wireless transmission module for communicating with an external processing terminal. After the sensor 31 collects physiological parameters and/or image information in the digestive tract, the information It is transmitted to the external processing terminal, and the external processing terminal analyzes the information and determines whether the sampling/medicating capsule has reached the position to be sampled and administered.
  • control module 3 also includes a battery 32 that provides power to other components, and the microprocessor and the wireless transmission module are usually integrated on the same circuit board 33.
  • the sampling/medicating capsule 100 of the present invention through the cooperation of the first unidirectional element 21, the second unidirectional element 23, the liquid-proof gas-permeable membrane 112, and the pump 26, can realize multiple sampling and medication application. .

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Anesthesiology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

一种采样/施药胶囊(100)，包括：外壳(1)，包括第一壳体(11)、第二壳体(12)，至少部分第一壳体(11)包括具有若干第一开孔的支撑体(111)、位于第一开孔处的防液透气膜(112)；采样/施药组件(2)，包括至少部分由防液透气膜(112)围设形成的储物腔(24)、位于外壳(1)内的暂储腔(22)、连通采样/施药胶囊(100)外与暂储腔(22)的第一单向元件(21)、连通暂储腔(22)与储物腔(24)的第二单向元件(23)、改变暂储腔(22)内压力的泵(26)，第一单向元件(21)、第二单向元件(23)的通向相同；控制模块(3)，包括与泵(26)通讯连接的微处理器。能够实现多次进样、施药。

Description

采样/施药胶囊 技术领域
本发明涉及医疗器械技术领域，尤其涉及一种能够多次进行采样、施药的采样/施药胶囊。
背景技术
目前，有很多关于消化道液体采样或药物施放的系统设计；然而，现有的消化道样本采集、药物施放装置的样本采集或药物施放只能进行单次动作。对于液体采样而言，单次采样如果失败，如采集到空气，则该装置就失效了，需要再次使用新的装置。
并且，现有的消化道样本采集装置被动采样，其采样速率与采样量难以估计：如果采样时间过长可能导致采样发生的区域出现较大变化，定位精度低，如果采样时间过短则可能导致样本量不足。
有鉴于此，有必要提供一种改进的采样/施药胶囊，以解决上述问题。
发明内容
本发明的目的在于提供一种能够多次进行采样、施药的采样/施药胶囊。
为实现上述发明目的，本发明采用如下技术方案：
一种采样/施药胶囊，其特征在于，包括：
外壳，包括第一壳体、第二壳体，至少部分所述第一壳体包括具有若干第一开孔的支撑体、位于所述支撑体内且位于所述第一开孔处的防液透气膜；
采样/施药组件，包括至少部分由所述防液透气膜围设形成的储物 腔、位于所述外壳内的暂储腔、连通所述采样/施药胶囊外与所述暂储腔的第一单向元件、连通所述暂储腔与所述储物腔的第二单向元件、改变所述暂储腔内压力的泵，所述第一单向元件、第二单向元件的通向相同；
控制模块，包括与所述泵通讯连接的微处理器。
进一步地，所述第一开孔的面积介于0.8mm 2～3mm 2之间。
进一步地，所述第一单向元件、所述第二单向元件分别选自单向阀或单向膜。
进一步地，所述泵包括能够反复向所述暂储腔抽气送气的气压泵、与所述气压泵连通的储气结构；
或，所述泵包括与所述暂储腔连通的隔膜、反复带动至少部分所述隔膜变形以改变所述暂储腔内压力的形变元件。
进一步地，所述形变元件为基于压电材料的压电微泵、基于双热变形系数金属的微泵以及基于形状记忆合金的微泵中的至少一种。
进一步地，所述泵的吸力和推力均不小于所述第一单向元件和所述第二单向元件的正向导通压力，且均不大于所述第一单向元件和所述第二单向元件的反向承受压力。
进一步地，所述第一单向元件、所述第二单向元件的正向导通压力阈值5kPa～15kPa，反向承受压力阈值50kPa～100kPa；所述泵的吸力介于20kPa～30kPa，推力介于30kPa～50kPa。
进一步地，所述采样/施药胶囊还包括设置于所述外壳内且位于所述第一壳体和所述第二壳体连接处的分隔壁、设于所述分隔壁朝向所述第二壳体的一侧的间隔壁，所述分隔壁与所述第一壳体围设形成所述储物腔，所述分隔壁、所述间隔壁及位于两者之间的结构共同围设形成所述暂储腔；所述第二壳体上具有与所述暂储腔连通的通道，所述第一单向元件设置于所述通道上；所述分隔壁上具有第二开孔，所述第二单向元件固定于所述第二开孔处。
进一步地，至少部分所述第一开孔位于与所述分隔壁相邻的部分所 述第一壳体上，所述通道位于与所述分隔壁相邻的部分所述第二壳体上。
进一步地，所述通道包括开设于所述第二壳体上的若干样孔、与若干所述样孔均连通的样腔；所述第一单向元件连通所述样腔与所述暂储腔。
进一步地，每个所述样孔的孔径小于与所述样腔连通的第一单向元件的孔径，和/或所述样腔内具有过滤结构。
与现有技术相比，本发明的有益效果是：本发明的采样/施药胶囊，通过第一单向元件、第二单向元件、防液透气膜和泵的配合，能够实现多次进样、施药。
附图说明
图1是本发明一较佳实施例的采样/施药胶囊沿轴向剖切的剖视图；
图2是图1所示的采样/施药胶囊在消化道液进入到暂储腔的工作状态示意图；
图3是图1所示的采样/施药胶囊的消化道液由暂储腔进入储物腔的工作状态示意图；
图4是本发明另一较佳实施例的采样/施药胶囊沿轴向剖切的剖视图；
图5是图1～图4中的第一壳体的平面图；
图6是图1～图4中的第一壳体的截面图。
具体实施方式
以下将结合附图所示的具体实施方式对本发明进行详细描述。但这些实施方式并不限制本发明，本领域的普通技术人员根据这些实施方式所做出的结构、方法、或功能上的变换均包含在本发明的保护范围内。
在本发明的各个图示中，为了便于图示，结构或部分的某些尺寸会 相对于其它结构或部分夸大，因此，仅用于图示本发明的主题的基本结构。
请参考图1～图6所示，为本发明较佳实施例的采样/施药胶囊100，包括外壳1、采样/施药组件2、控制模块3。其中，所述控制模块3包括与采样/施药组件2中的至少部分结构通讯连接的微处理器，以控制其工作状态。
所述外壳1具有生物兼容性且不会被消化液腐蚀，根据需要可设置为透明或不透明；具体地，所述外壳1包括第一壳体11和第二壳体12。
请参阅图5和图6所示，至少部分所述第一壳体11包括具有若干第一开孔的支撑体111、位于所述支撑体111内且位于所述第一开孔处的防液透气膜112。优选地，全部所述第一壳体11包括支撑体111和防液透气膜112。
具体地，所述支撑体111上设置所述第一开孔的密度不限，所述支撑体111可以仅包括几个所述第一开孔，所述支撑体111也可以为所述第一开孔的数量较多的网格结构，此时所述第一开孔也可以称为网格孔。所述第一开孔的形状不限，可以为圆孔、方孔或其他不规则的孔。例如，所述支撑体111为网格结构时，所述第一开孔或称网格孔的孔径介于10目～18目，或称孔径1mm～2mm，或称孔的面积0.8mm 2～3mm 2。
所述防液透气膜112对气体有较好的透气性，但对液体有很好的阻碍能力，因此空气能够经过所述第一壳体11自由进出所述外壳1内，而消化道液不能随意通过。一具体实施例中，所述防液透气膜112的防水等级为IPX8。
所述采样/施药组件2包括设于至少部分由所述防液透气膜112围设形成的储物腔24、位于所述外壳1内的暂储腔22、连通所述采样/施药胶囊100外与所述暂储腔22的第一单向元件21、连通所述暂储腔22与所述储物腔24的第二单向元件23、改变所述暂储腔22内压力的泵26，所述第一单向元件21、第二单向元件23的通向相同。所述储物腔24可 通过所述防液透气膜112与所述采样/施药胶囊100外连通。其中，所述泵26为电控元件，与所述微处理器通讯连接。
本领域技术人员可以理解的是，“所述第一单向元件21、第二单向元件23的通向相同”指的是供采样样本或药物流动的方向一致。包括两种情形，所述第一单向元件21通向所述暂储腔22，所述第二单向元件23通向所述储物腔24，此时可以实现采样功能；或，所述第二单向元件23通向所述暂储腔22，所述第一单向元件21通向所述采样/施药胶囊100外，此时可以实现施药功能。
所述采样/施药胶囊100集采样、施药功能于一体，既可以作为采样胶囊，也可以作为施药胶囊。作为采样胶囊进行采样时，所述储物腔24为空的，用于存储在消化道特定部位采取的样本。作为施药胶囊进行施药时，所述储物腔24内填充有需要释放的药物，多为液体药物，待所述采样/施药胶囊100到达消化道特定部位时向外释放药物。
具体地，如图1所示的具体实施例中，所述采样/施药胶囊100还包括设置于所述外壳1内且位于所述第一壳体11和所述第二壳体12连接处的分隔壁13，所述分隔壁13与所述第一壳体11围设形成所述储物腔24。所述分隔壁13位于所述第一壳体11和所述第二壳体12连接处并将所述第一壳体11和所述第二壳体12内部分割为两个空间，具体包括，所述分隔壁13位于所述第一壳体11朝向所述第二壳体12的端部；或，所述分隔壁13位于所述第一壳体11与所述第二壳体12中间；或，如图1所示的，所述分隔壁13位于所述第二壳体12朝向所述第一壳体11的端部。
所述采样/施药胶囊100还包括设于所述分隔壁13朝向所述第二壳体12的一侧的间隔壁14，所述分隔壁13、所述间隔壁14及位于两者之间的结构共同围设形成所述暂储腔22。一具体实施例中，所述暂储腔22由所述分隔壁13、所述间隔壁14及位于两者之间的第二壳体12或附接于第二壳体12内的结构共同围设形成。
所述第一单向元件21固定于所述第二壳体12上，并连通所述外壳1外与所述暂储腔22。所述第二单向元件23固定于所述分隔壁13上，并连通所述暂储腔22与所述储物腔24。优选地，所述第二单向元件23固定于所述分隔壁13的中间位置处，样本/药品能够顺畅地通过。
所述第一单向元件21、所述第二单向元件23分别选自单向阀或单向膜等。单向阀仅允许消化液及气体单向通过，反向能够承受50kPa～100kPa的压力而不会渗入，单向阀的安装方式为，在相应位置处开孔，单向阀密封设于开孔处；例如，单向阀密封设于开孔内。单向膜同样仅允许单向通过，安装方式为，在相应位置处开孔，所述单向膜遮蔽所述开孔。
具体地，位于所述分隔壁13与所述间隔壁14中间的所述第二壳体12上具有通道，所述第一单向元件21设置于所述通道上，以控制样品或药品单向通过所述通道。所述分隔壁13上具有第二开孔，所述第二单向元件23固定于所述第二开孔处；例如，所述第二单向元件23固定于所述第二开孔内。
优选地，至少部分所述第一开孔位于与所述分隔壁13相邻的部分所述第一壳体11上，所述通道位于与所述分隔壁13相邻的部分所述第二壳体12上，此时所述第一开孔与所述通道的距离较近，中间仅隔了一个分隔壁13，能维持系统各腔体压差在可接受范围内，不会导致泵26的负载过高而失效。
进一步地，所述通道包括开设于所述外壳1上的若干样孔27、与若干所述样孔27均连通的样腔28，所述第一单向元件21连通所述样腔28与所述暂储腔22。
当所述第一单向元件21通向所述暂储腔22、所述第二单向元件23通向所述储物腔24时，则所述样孔27为采样孔27，可以起到防堵作用。
采样时，消化道内的气、液通过所述样孔27进入所述样腔28并汇聚入所述暂储腔22内，即使部分样孔27被堵塞时，仍有部分保持导通， 不会影响采样。另外，通过所述样腔28可以对通过各个样孔27进入的消化液进行混合和缓冲，保证采样均匀且平稳地进行。
进一步地，每个所述样孔27的孔径小于与所述样腔28连通的第一单向元件21的孔径，因此，能通过所述样孔27进入所述样腔28的物质，不会堵塞所述暂储腔22。
或，所述样腔28内具有过滤结构(未图示)，例如但不限于过滤网等，避免食物残渣堵塞所述暂储腔22，所述过滤结构可参考第201811330328.4号专利发明“消化液采样胶囊系统中防堵塞防吸入空气的结构设计”。
或，每个所述样孔27的孔径小于与所述样腔28连通的第一单向元件21的孔径的同时，也可以在所述样腔28内设置过滤结构，起到双重防堵的效果。
所述若干样孔27沿所述采样/施药胶囊100的长度方向或圆周方向间隔分布，能保证顺畅地采样/施药。
当然，也可以采用如下方式：所述第二单向元件23通向所述暂储腔22，所述第一单向元件21通向所述采样/施药胶囊100外。基于该通向，施药时，药物自所述储物腔24进入所述暂储腔22，再由所述暂储腔22进入所述样腔28并充分混合后，通过多个样孔27向消化道释放，扩大了施药范围。
一具体实施例中，所述样孔27靠近所述分隔壁13设置，且整个所述第一壳体11包括支撑体111和防液透气膜112，所述第一开孔/所述防液透气膜112与所述样孔27的距离很近，中间仅隔了一个分隔壁13，能维持系统各腔体压差在可接受范围内，不会导致泵26的负载过高而失效。
设定所述储物腔24内的压力为P0，暂储腔22内的压力P1，外界的环境压力为P2。所述第一壳体11上有诸多第一开孔，且所述防液透气膜112的透气性良好，因此所述防液透气膜112内外的压力在一小段时 间内会达到平衡，即所述储物腔24内的压力与外界的环境压力相等。由于暂储腔22与外界通过第一单向元件21和第二单向元件23连接，因此暂储腔22内的压力P1与压力P0可能会有所不同。根据单向阀的性能，当系统达到平衡的时候，(A)外界没有气、液流入暂储腔22；(B)暂储腔22也不会有气、液流入储物腔24。此时，说明：
(A)P0–P1≤△P；
(B)P1–P0≤△P。
综合上述条件，则：|P1–P0|≤△P。其中△P为第一单向元件21、第二单向元件23的正向导通压力阈值。
具体地，如果整个储物腔24外的第一壳体11均为网格结构等多孔结构，防液透气膜112覆盖在内，样孔27与第一壳体11之间仅间隔了一个分隔壁13，优选地，分隔壁13的厚度约1mm。故样孔27和第一壳体11上的某些第一开孔基本上处于同一空间中。如果肠道由于蠕动等造成局部空间的环境压力变化，储物腔24内压力会同步变化。
如果外界的环境压力增大，即P2>P0，且P2>P1+△P，此时外界气、液将通过第一单向元件21进入暂储腔22，暂储腔22压力逐渐升高。当暂储腔22内压力达到P2-△P后，外界压力不足以推开第一单向元件21，则气、液停止向内流动。此时，内部气、液无法推开第二单向元件23进入储物腔24内。
如果外界的环境压力减小,即P2<P0，且P2+△P<P1，此时暂储腔22内气、液会进入储物腔24内，直到暂储腔22内压力减小到P2+△P后停止。此时，外界气、液无法通过第一单向元件21进入暂储腔22。
综上分析，当泵26开启后，由于肠道蠕动造成环境压力变化时，暂储腔22内压力始终可保持在环境压力的±△P之间。同时储物腔24内压力可保持和防液透气膜112(样孔27)外环境压力一致。因为泵26的吸力及推力均高于△P，故不会导致微型泵吞吐失效，即不会由于负载过高，无法运行。
所述泵26用于改变所述暂储腔22内压力，配合所述第一单向元件21、第二单向元件23的通向及所述防液透气膜112，完成采样或施药。
一类实施例中，如图1～图3所示，所述第一单向元件21通向所述暂储腔22，所述第二单向元件23通向所述储物腔24，消化道液的流向为：依次经所述第一单向元件21、所述暂储腔22、所述第二单向元件23、所述储物腔24，该过程中掺杂在所述消化道液内的气体会经过所述防液透气膜112排出至外壳1外。
采样过程具体为：请参阅2所示，所述泵26减小所述暂储腔22的压力，消化道的消化液在内外压差作用下穿过所述第一单向元件21进入所述暂储腔22；然后参阅图3所示，所述泵26增大所述暂储腔22内压力，消化液经过所述第二单向元件23进入所述储物腔24内，完成采样。
另一类实施例中，如图4所示，所述第二单向元件23通向所述暂储腔22，所述第一单向元件21通向所述采样/施药胶囊100外，在所述泵26工作过程中，消化道内的部分空气经所述防液透气膜112进入到所述储物腔24使其压强增大，使得其内部储存的药品等经过所述第二单向元件23进入所述暂储腔22，再经过第一单向元件21流出至消化道内。
施药过程具体为：所述泵26减小所述暂储腔22的压力，所述储物腔24内的气体/药物经过所述第二单向元件23进入所述暂储腔22使得所述储物腔24的压力减小，消化道的气体在内外压差作用下穿过所述防液透气膜112进入所述储物腔24，推动药物穿过所述第二单向元件23进入所述暂储腔22；然后，所述泵26增大所述暂储腔22内压力，药物经过所述第一单向元件21排出所述采样/施药胶囊100外。
为了保证消化道液或药物的单向通过，所述泵26的吸力和推力均不小于所述第一单向元件21和所述第二单向元件23的正向导通压力，且均不大于所述第一单向元件21和所述第二单向元件23的反向承受压力。
一具体实施例中，所述第一单向元件21、所述第二单向元件23的正向导通压力阈值5kPa～15kPa，反向承受压力阈值50kPa～100kPa；所 述泵26的吸力介于20kPa～30kPa，推力介于30kPa～50kPa。
具体地，一种实施例中，所述泵26包括与所述暂储腔22连通的隔膜261、反复带动至少部分所述隔膜261变形以改变所述暂储腔22内压力的形变元件262。具体地，所述隔膜261设置于所述间隔壁14上，或所述间隔壁14整体为所述隔膜261，所述隔膜261发生形变时，所述暂储腔22的体积发生变化，进而压力发生变化。
一具体实施例中，所述形变元件262为基于压电材料的压电微泵，给压电微泵施加电压时，压电材料会发生弯曲，带动所述隔膜261弯曲，以增大或减小所述暂储腔22内的压力。
以采样为例，请参考图2和图3所示，给所述压电微泵施加电压，所述压电材料背向所述储物腔24弯曲，带动所述隔膜261背向所述储物腔24弯曲以增大所述暂储腔22的体积、减小所述暂储腔22的压力，消化道的消化液在内外压差作用下穿过所述第一单向元件21进入所述暂储腔22；然后，消除施加电压，所述压电材料恢复原状带动所述隔膜261恢复原状，或施加反向电压，所述压电材料朝向所述储物腔24弯曲，带动所述隔膜261朝向所述储物腔24弯曲以减小所述暂储腔22的体积，所述暂储腔22内压强增大，使得消化液经过所述第二单向元件23进入所述储物腔24内，完成采样。
进样时，有空气进入到所述储物腔24内后，空气经过所述防液透气膜112排出胶囊外，再重复上述动作，重新完成进样。多次进样，采集的液体都会被保存下来，而吸入的空气则会被自动排出，保证消化道液等液体样品的采集，避免了由于吸收空气占据了所述储物腔24的空间，导致采样量不足或失效的问题。
或，所述形变元件262为基于双热变形系数金属的双金属微泵，双金属微泵由相对固定的两种不同的金属膜片组成，由于两种金属膜片受热的形变系数不同，当利用加热元件，如电阻，给它们加热时，两者发生不同程度的形变，因此可使双金属微泵发生变形，并带动所述隔膜261 发生形变，进而改变所述暂储腔22的压力。
如图2所示，加热时，所述双金属微泵背向所述储物腔24弯曲，从而带动所述隔膜261背向所述储物腔24弯曲，减小所述暂储腔22的压力；停止加热，温度恢复后，双金属微泵形状恢复，所述隔膜261形状恢复，所述暂储腔22内压力增大。
该实施例中，基于压力变化进行采样的原理和过程与上述实施例相同，于此不再赘述。
或，所述形变元件262为基于形状记忆合金的微泵。基于形状记忆合金的微泵由形状记忆合金制成，当使用加热元件使其温度升高到一定温度时，形状记忆合金将发生形变，并带动所述隔膜261发生形变，进而改变所述暂储腔22的压力。
如图2所示，加热时，所述基于形状记忆合金的微泵背向所述储物腔24弯曲，从而带动所述隔膜261背向所述储物腔24弯曲，减小所述暂储腔22的压力；停止加热，温度恢复后，基于形状记忆合金的微泵形状恢复，所述隔膜261形状恢复，所述暂储腔22内压力增大。
该实施例中，基于压力变化进行采样的原理和过程与上述实施例相同，于此不再赘述。
当周期性地给所述形变元件262施加能够使其变形的信号，例如电压、加热，使得所述形变元件262在变形与恢复原状之间反复转换，所述暂储腔22的压强会反复地先变小再变大，能够多次进行采样，避免单次采样的各种弊端。
或者，其他实施例中，所述泵26包括能够反复给所述暂储腔22抽气送气的气压泵26、与所述气压泵26连通的储气结构。所述气压泵26通过将所述暂储腔22的气体抽送入所述储气结构内，或将所述储气结构内的气体抽送入所述暂储腔22，改变所述暂储腔22的气压，进而控制样本的流动。
其中，所述储气结构的体积被设定为，气体在所述暂储腔22与所述 储气结构内流通时，能够产生足够的压力差来满足采样或施药的需求。
进一步地，所述采样/施药组件2还包括设置于所述第一壳体11上的第三开孔、位于所述第三开孔处的胶塞25，例如，所述胶塞25过盈配合安装于所述第三开孔内，既方便向所述储物腔24内注入药物，也方便在采样后，通过注射器等刺穿所述胶塞25回收样品。
一般情况下，当所述采样/施药胶囊100处于需要检查的消化道部位、或到达具有病变的消化道部位时，即可进行采样或施药。
所述控制模块3还包括用于采集消化道内的生理参数和/或图像信息的传感器31，所述传感器31与微处理器通讯连接。所述传感器31为图像传感器、或pH传感器、或超声传感器中的至少一种；所述传感器31包括图像传感器时，部分所述外壳1呈透明状；所述传感器31包括pH传感器时，所述外壳1上具有窗口。根据所述传感器31获取的图片、pH值判断所述采样/施药胶囊处于消化道的哪个部位，具体判断方法可采用现有技术中的任意方法，于此不再赘述。
当然，所述控制模块3在包括所述传感器31的同时，还可以包括用于存储消化道内不同部位的正常的生理参数或图像信息、可能的病变时的生理参数或图像信息的储存模块，所述储存模块与所述微处理器通讯连接。当所述传感器31采集消化道内的生理参数和/或图像信息后，所述微处理器比较上述信息与所述储存模块中的信息，以确定所述采样/施药胶囊是否达到待取样、施药的位置处。
或者，所述控制模块3在包括所述传感器31的同时还包括用以与外界处理终端通讯连接的无线传输模块，当所述传感器31采集消化道内的生理参数和/或图像信息后，将信息传输给所述外界处理终端，外界处理终端对信息进行分析后确定采样/施药胶囊是否达到待取样、施药的位置处。
另外，所述控制模块3还包括给其他元件提供电源的电池32，且所述微处理器、所述无线传输模块通常集成于同一电路板33上。
本发明的采样/施药胶囊可通过所述控制模块3与外界处理终端通讯连接，所述控制模块3与所述外界处理终端通讯连接的方式采用现有技术中的任意一种，于此不再赘述。
综上所述，本发明的采样/施药胶囊100，通过第一单向元件21、第二单向元件23、防液透气膜112和泵26的配合，能够实现多次进样、施药。
应当理解，虽然本说明书按照实施方式加以描述，但并非每个实施方式仅包含一个独立的技术方案，说明书的这种叙述方式仅仅是为清楚起见，本领域技术人员应当将说明书作为一个整体，各实施方式中的技术方案也可以经适当组合，形成本领域技术人员可以理解的其他实施方式。
上文所列出的一系列的详细说明仅仅是针对本发明的可行性实施方式的具体说明，它们并非用以限制本发明的保护范围，凡未脱离本发明技艺精神所作的等效实施方式或变更均应包含在本发明的保护范围之内。

Claims (11)

  1. 一种采样/施药胶囊，其特征在于，包括：
    外壳，包括第一壳体、第二壳体，至少部分所述第一壳体包括具有若干第一开孔的支撑体、位于所述支撑体内且位于所述第一开孔处的防液透气膜；
    采样/施药组件，包括至少部分由所述防液透气膜围设形成的储物腔、位于所述外壳内的暂储腔、连通所述采样/施药胶囊外与所述暂储腔的第一单向元件、连通所述暂储腔与所述储物腔的第二单向元件、改变所述暂储腔内压力的泵，所述第一单向元件、第二单向元件的通向相同；
    控制模块，包括与所述泵通讯连接的微处理器。
  2. 根据权利要求1所述的采样/施药胶囊，其特征在于：所述第一开孔的面积介于0.8mm 2～3mm 2之间。
  3. 根据权利要求1所述的采样/施药胶囊，其特征在于：所述第一单向元件、所述第二单向元件分别选自单向阀或单向膜。
  4. 根据权利要求1所述的采样/施药胶囊，其特征在于：所述泵包括能够反复向所述暂储腔抽气送气的气压泵、与所述气压泵连通的储气结构；
    或，所述泵包括与所述暂储腔连通的隔膜、反复带动至少部分所述隔膜变形以改变所述暂储腔内压力的形变元件。
  5. 根据权利要求4所述的采样/施药胶囊，其特征在于：所述形变元件为基于压电材料的压电微泵、基于双热变形系数金属的微泵以及基于形状记忆合金的微泵中的至少一种。
  6. 根据权利要求1所述的采样/施药胶囊，其特征在于：所述泵的吸力和推力均不小于所述第一单向元件和所述第二单向元件的正向导通压力，且均不大于所述第一单向元件和所述第二单向元件的反向承受压力。
  7. 根据权利要求6所述的采样/施药胶囊，其特征在于：所述第一单 向元件、所述第二单向元件的正向导通压力阈值5kPa～15kPa，反向承受压力阈值50kPa～100kPa；所述泵的吸力介于20kPa～30kPa，推力介于30kPa～50kPa。
  8. 根据权利要求1所述的采样/施药胶囊，其特征在于：所述采样/施药胶囊还包括设置于所述外壳内且位于所述第一壳体和所述第二壳体连接处的分隔壁、设于所述分隔壁朝向所述第二壳体的一侧的间隔壁；所述分隔壁与所述第一壳体围设形成所述储物腔，所述分隔壁、所述间隔壁及位于两者之间的结构共同围设形成所述暂储腔；所述第二壳体上具有与所述暂储腔连通的通道，所述第一单向元件设置于所述通道上；所述分隔壁上具有第二开孔，所述第二单向元件固定于所述第二开孔处。
  9. 根据权利要求8所述的采样/施药胶囊，其特征在于：至少部分所述第一开孔位于与所述分隔壁相邻的部分所述第一壳体上，所述通道位于与所述分隔壁相邻的部分所述第二壳体上。
  10. 根据权利要求8所述的采样/施药胶囊，其特征在于：所述通道包括开设于所述第二壳体上的若干样孔、与若干所述样孔均连通的样腔；所述第一单向元件连通所述样腔与所述暂储腔。
  11. 根据权利要求10所述的采样/施药胶囊，其特征在于：每个所述样孔的孔径小于与所述样腔连通的第一单向元件的孔径，和/或所述样腔内具有过滤结构。
PCT/CN2021/090280 2020-04-30 2021-04-27 采样/施药胶囊 WO2021218972A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17/922,496 US20230263509A1 (en) 2020-04-30 2021-04-27 Capsule for fluid sampling and drug delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010360917.8A CN111419293A (zh) 2020-04-30 2020-04-30 采样/施药胶囊
CN202010360917.8 2020-04-30

Publications (1)

Publication Number Publication Date
WO2021218972A1 true WO2021218972A1 (zh) 2021-11-04

Family

ID=71554954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2021/090280 WO2021218972A1 (zh) 2020-04-30 2021-04-27 采样/施药胶囊

Country Status (3)

Country Link
US (1) US20230263509A1 (zh)
CN (1) CN111419293A (zh)
WO (1) WO2021218972A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111419293A (zh) * 2020-04-30 2020-07-17 安翰科技(武汉)股份有限公司 采样/施药胶囊
CN111419292A (zh) * 2020-04-30 2020-07-17 安翰科技(武汉)股份有限公司 采样/施药胶囊
CN112168179A (zh) * 2020-11-02 2021-01-05 曹洪美 一种内植式激素监测及辅助分泌装置

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105555334A (zh) * 2013-06-17 2016-05-04 迷你泵有限责任公司 排气式可植入药物传送装置
CN106137099A (zh) * 2016-09-27 2016-11-23 重庆大学 基于云端服务的智能胶囊检测系统
CN107158552A (zh) * 2016-03-07 2017-09-15 上海理工大学 药物输送胶囊及药物输送方法
CN108619611A (zh) * 2018-05-04 2018-10-09 哈尔滨工业大学深圳研究生院 一种具有多方向施药功能的肠道微型胶囊机器人
CN109009246A (zh) * 2018-10-19 2018-12-18 安翰光电技术（武汉）有限公司 采样胶囊及采样胶囊系统
US20180368730A1 (en) * 2016-03-04 2018-12-27 University Of Miami Ingestible Capsule Device for Collecting Fluid Aspirates
CN109222874A (zh) * 2018-11-09 2019-01-18 安翰光电技术（武汉）有限公司 消化道采样胶囊
CN111419293A (zh) * 2020-04-30 2020-07-17 安翰科技(武汉)股份有限公司 采样/施药胶囊
CN212489976U (zh) * 2020-04-30 2021-02-09 安翰科技(武汉)股份有限公司 采样/施药胶囊

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105555334A (zh) * 2013-06-17 2016-05-04 迷你泵有限责任公司 排气式可植入药物传送装置
US20180368730A1 (en) * 2016-03-04 2018-12-27 University Of Miami Ingestible Capsule Device for Collecting Fluid Aspirates
CN107158552A (zh) * 2016-03-07 2017-09-15 上海理工大学 药物输送胶囊及药物输送方法
CN106137099A (zh) * 2016-09-27 2016-11-23 重庆大学 基于云端服务的智能胶囊检测系统
CN108619611A (zh) * 2018-05-04 2018-10-09 哈尔滨工业大学深圳研究生院 一种具有多方向施药功能的肠道微型胶囊机器人
CN109009246A (zh) * 2018-10-19 2018-12-18 安翰光电技术（武汉）有限公司 采样胶囊及采样胶囊系统
CN109222874A (zh) * 2018-11-09 2019-01-18 安翰光电技术（武汉）有限公司 消化道采样胶囊
CN111419293A (zh) * 2020-04-30 2020-07-17 安翰科技(武汉)股份有限公司 采样/施药胶囊
CN212489976U (zh) * 2020-04-30 2021-02-09 安翰科技(武汉)股份有限公司 采样/施药胶囊

Also Published As

Publication number Publication date
CN111419293A (zh) 2020-07-17
US20230263509A1 (en) 2023-08-24

Similar Documents

Publication Publication Date Title
WO2021218972A1 (zh) 采样/施药胶囊
WO2021218971A1 (zh) 采样/施药胶囊
JP3269886B2 (ja) 埋め込み型装置
US5895372A (en) Implantable dosaging system
US4715852A (en) Implanted medication infusion device
CN212489976U (zh) 采样/施药胶囊
US11116389B2 (en) Gastrointestinal sampling capsule
ES2815529T3 (es) Bomba peristáltica giratoria sin impulsos
WO2023036296A1 (zh) 一种给药胶囊
US8231598B2 (en) Propellant bag improvement
CN213075718U (zh) 采样/施药胶囊
US20060064052A1 (en) Liquid delivering device
CN114451926B (zh) 采样胶囊
CN210811903U (zh) 一种造口脱垂辅助治疗装置
CN111685715B (zh) 一种可视化消化道采样释药胶囊
JP2835051B2 (ja) 医療用カプセル
US20240237973A1 (en) Intestinal capsule assembly
CN220917438U (zh) 采样胶囊及采样胶囊系统
CN220609437U (zh) 一种防鼻胃管堵塞的过滤装置
CN217852884U (zh) 胶囊系统
US20150190568A1 (en) Pressure management for implantable drug-delivery devices
US20220296791A1 (en) Disposable surgical drain bulb for the secure collection of exudate
GB2607276A (en) Intestinal capsule assembly
CN214937519U (zh) 一种细胞生物基因工程用羊膜消化液灭菌杯
CN214485219U (zh) 输液装置及输液器

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21797053

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21797053

Country of ref document: EP

Kind code of ref document: A1