WO2021215274A1 - Composition d'agent externe pour la peau et déodorant - Google Patents

Composition d'agent externe pour la peau et déodorant Download PDF

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Publication number
WO2021215274A1
WO2021215274A1 PCT/JP2021/015072 JP2021015072W WO2021215274A1 WO 2021215274 A1 WO2021215274 A1 WO 2021215274A1 JP 2021015072 W JP2021015072 W JP 2021015072W WO 2021215274 A1 WO2021215274 A1 WO 2021215274A1
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WIPO (PCT)
Prior art keywords
mass
acetate
isopropylmethylphenol
methyl
oil
Prior art date
Application number
PCT/JP2021/015072
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English (en)
Japanese (ja)
Inventor
ゆりの 芦澤
薫 森下
Original Assignee
株式会社 資生堂
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Publication of WO2021215274A1 publication Critical patent/WO2021215274A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants

Definitions

  • the present disclosure relates to a skin external preparation composition containing isopropylmethylphenol.
  • the present disclosure relates to a deodorant for deodorizing the odor of isopropylmethylphenol.
  • Isopropylmethylphenol is known as a bactericidal component and an antibacterial component (see, for example, Patent Document 1).
  • Patent Document 1 discloses a dentifrice composition using isopropylmethylphenol as a bactericidal component.
  • one or more fragrance components selected from 3-octanol, 3-octyl acetate, 3-octanone and fenchone in order to reduce the dislike of isopropylmethylphenol. Is compounded.
  • Isopropylmethylphenol has an unpleasant odor. For example, even if an attempt is made to suppress the generation of odor due to bacterial growth by blending isopropylmethylphenol with a deodorant agent, if the unpleasant odor of isopropylmethylphenol remains, it cannot play a role as a deodorant agent. Therefore, it has been difficult to utilize the bactericidal action of isopropylmethylphenol in the composition for suppressing the odor.
  • the first aspect of the present disclosure contains isopropylmethylphenol and a first component of 1 ⁇ 10 -5 parts by mass to 5 ⁇ 10 -1 parts by mass with respect to 1 part by mass of isopropylmethylphenol.
  • a skin external preparation composition is provided.
  • the first component is 7-acetyl-1,2,3,4,5,6,7,8-octahydro-1,1,6,7-tetramethylnaphthalene, lime oil, 1-methyl-2-[ (1,2,2-trimethylbicyclo [3.1.0] hexane-3-yl) Methyl] Cyclopropane-1-Methanol, limonene, ⁇ -terpinene, lemon oil, orange oil, linalool, damasenone, bergamot oil , Cis-3-hexenyl salicylate, ethyl 2-methylbutyrate, hexyl cinnamic aldehyde, ethyl linalool, geraniol, ambroxide, ethyltrimethylcyclopentenyl butenol, ⁇ -ionone, ⁇ -ionone, 3,7-dimethyl-2, It comprises at least one selected from the group consisting of 6-nonadiennitrile, 2,
  • a deodorant for deodorizing the odor of isopropylmethylphenol is provided.
  • Deodorants are 7-acetyl-1,2,3,4,5,6,7,8-octahydro-1,1,6,7-tetramethylnaphthalene, lime oil, 1-methyl-2-[(1).
  • the external preparation composition for skin of the present disclosure it is possible to suppress the odor caused by isopropylmethylphenol while utilizing the bactericidal action of isopropylmethylphenol.
  • the odor of isopropylmethylphenol can be effectively deodorized.
  • the amount of isopropylmethylphenol is 0.2% by mass to 0.5% by mass with respect to the mass of the external preparation composition for skin.
  • the skin external preparation composition is applied to an antiperspirant.
  • POE is an abbreviation for polyoxyethylene and POP is an abbreviation for polyoxypropylene, and the number in parentheses after POE or POP represents the average number of moles of POE group or POP group added in the compound.
  • the "substantial amount” means an amount in which the action and effect of the addition of the compound can occur.
  • the skin external preparation composition according to the first embodiment of the present disclosure will be described.
  • the external preparation composition for skin of the present disclosure can be an aqueous composition, an oily composition, an emulsion, or a non-emulsified composition.
  • the external preparation composition for skin according to the first embodiment contains isopropylmethylphenol (3-methyl-4-isopropylphenol).
  • Isopropylmethylphenol can be used, for example, as a bactericidal component, an antibacterial component, an ultraviolet absorbing component, an antioxidant component and the like.
  • the content of isopropylmethylphenol is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, and more preferably 0.3% by mass or more, based on the mass of the external preparation composition for skin. And even more preferable. If the content of isopropylmethylphenol is less than 0.1% by mass, the isopropylmethylphenol cannot exert a sufficient action (for example, a bactericidal action).
  • the content of isopropylmethylphenol can be 1% by mass or less, 0.5% by mass or less, or 0.3% by mass or less with respect to the mass of the external preparation composition for skin.
  • the external preparation composition for skin according to the first embodiment further contains a component ((A) first component) for suppressing or deodorizing the odor of isopropylmethylphenol.
  • the first component can suppress the odor of isopropylmethylphenol by, for example, a masking action and / or a harmonizing action.
  • the deodorization referred to in the present disclosure is to prevent or alleviate the odor to be deodorized (hereinafter referred to as "bad odor") by a sensory action.
  • bad odor As the deodorizing action in the present disclosure, a masking action (masking effect) and a harmonizing action (harmonizing effect) can be considered.
  • masking refers to competing a good scent (fragrance, aroma) superior to a bad odor with respect to a bad odor to relatively deodorize the bad odor (eliminate or alleviate the bad odor).
  • harmonizing is to deodorize a bad odor by mixing a scent that is in harmony with the bad odor with the bad odor and harmonizing the odor as a whole (for example, converting the bad odor into an aroma / aroma). Eliminate or alleviate).
  • (A) As the first component for example, at least one selected from the group of compounds shown in Table 1 can be mentioned.
  • the components (A1) to (A15) have a masking action and a harmonizing action on the isopropylmethylphenol odor.
  • Ingredients (A16) to (A23) have a masking effect on the odor of isopropylmethylphenol.
  • the components (A1), (A3), and (A17) have a woody scent.
  • the components (A2), (A4) to (A7), (A10) and (A20) have a citrus-based scent. From this, at least woody and citrus scent components are preferable as deodorant components for isopropylmethylphenol.
  • the first component preferably contains at least one of the components (A1), (A4), and (A8).
  • the first component is preferably 1 ⁇ 10-5 parts by mass or more with respect to 1 part by mass of isopropylmethylphenol.
  • the first component is, for example, 5 ⁇ 10 -5 parts by mass or more, 1 ⁇ 10 -4 parts by mass or more, 5 ⁇ 10 -4 parts by mass or more, and 1 ⁇ 10 -3 with respect to 1 part by mass of isopropylmethylphenol. It can be 5 ⁇ 10 -3 parts by mass or more, 1 ⁇ 10 -2 parts by mass or more, or 5 ⁇ 10 -2 parts by mass or more. If the first component is less than 1 ⁇ 10 -5 parts by mass, a sufficient deodorizing effect cannot be obtained.
  • the first component is preferably 5 ⁇ 10 -1 part by mass or less with respect to 1 part by mass of isopropylmethylphenol.
  • the first component is, for example, 1 ⁇ 10 -1 part by mass or less, 5 ⁇ 10 -2 parts by mass or less, 1 ⁇ 10 -2 parts by mass or less, and 5 ⁇ 10 -3 with respect to 1 part by mass of isopropylmethylphenol. It may be 1 ⁇ 10 -3 parts by mass or less, 5 ⁇ 10 -4 parts by mass or less, or 1 ⁇ 10 -4 parts by mass or less.
  • the first component comprises at least one selected from the group consisting of components (A9), (A11), (A12), (A16), (A20) and (A21), the first component is isopropyl.
  • the first component may be 1 ⁇ 10 -4 parts by mass or more, 5 ⁇ 10 -4 parts by mass or more, or 1 ⁇ 10 -3 parts by mass or more with respect to 1 part by mass of methylphenol.
  • the first component is the component (A2), (A3), (A5), (A6), (A7), (A10), (A15), (A17), (A18), (A19), (A22) and
  • the first component is, for example, 1 ⁇ 10 -3 parts by mass or more and 5 ⁇ 10 -3 parts by mass with respect to 1 part by mass of isopropylmethylphenol. It can be more than a part, or 1 ⁇ 10-2 parts by mass or more.
  • the first component comprises at least one selected from the group consisting of components (A1), (A4), (A8), (A13), and (A14), the first component is isopropylmethylphenol 1.
  • it may be 1 ⁇ 10-2 parts by mass or more, 5 ⁇ 10-2 parts by mass or more, or 1 ⁇ 10 -1 parts by mass or more with respect to the mass part.
  • At least one component ((B) second component) selected from the group of compounds shown in Table 2 is 5 with respect to 1 part by mass of isopropylmethylphenol. It is preferably ⁇ 10 -1 part by mass or less, and more preferably 1 ⁇ 10 -2 part by mass or less.
  • the second component is, for example, 5 ⁇ 10 -3 parts by mass or less, 1 ⁇ 10 -3 parts by mass or less, 5 ⁇ 10 -4 parts by mass or less, 1 ⁇ 10 -4 with respect to 1 part by mass of isopropylmethylphenol. parts by mass or less, 5 ⁇ 10 -5 parts by weight or less, or 1 ⁇ may be 10 -5 parts by weight or less. It is more preferable that the external preparation composition for skin does not substantially contain the second component.
  • the second component comprises at least one selected from the group consisting of components (B6), (B8), (B11), (B12), (B18), (B20) and (B24), the second component.
  • the component can be, for example, 5 ⁇ 10-2 parts by mass or less, 1 ⁇ 10 -2 parts by mass or less, or 5 ⁇ 10 -3 parts by mass or less with respect to 1 part by mass of isopropylmethylphenol.
  • the second component is from components (B1), (B2), (B7), (B9), (B10), (B16), (B17), (B19), (B23), (B25) and (B29).
  • the second component When containing at least one selected from the group, the second component is, for example, 5 ⁇ 10 -3 parts by mass or less, or 1 ⁇ 10 -3 parts by mass or less, or 1 part by mass or less, based on 1 part by mass of isopropylmethylphenol. It can be 5 ⁇ 10 -4 parts by mass or less. If the second component comprises at least one selected from the group consisting of components (B4), (B5), (B14), (B21), (B22), (B26), and (B28), the second component.
  • the component of isopropylmethylphenol can be, for example, 5 ⁇ 10 -4 parts by mass or less, 1 ⁇ 10 -4 parts by mass or less, or 5 ⁇ 10 -5 parts by mass or less with respect to 1 part by mass of isopropylmethylphenol.
  • the second component contains at least one selected from the group consisting of components (B3), (B13), (B15), and (B27)
  • the second component is based on 1 part by mass of isopropylmethylphenol.
  • it can be 5 ⁇ 10 -4 parts by mass or less, 1 ⁇ 10 -4 parts by mass or less, 5 ⁇ 10 -5 parts by mass or less, or 1 ⁇ 10 -5 parts by mass or less.
  • the scent of the components (B1) to (B29) becomes an unpleasant odor when combined with the odor of isopropylmethylphenol.
  • the components (B11), (B12), (B23) and (B24) have a musk-based scent.
  • (B3) and (B13) have an aldehyde-based scent. From this, musk-based and aldehyde-based scent components tend to have an unpleasant effect on isopropylmethylphenol.
  • the external preparation composition for skin of the present disclosure it is possible to suppress an unpleasant odor caused by isopropylmethylphenol while blending isopropylmethylphenol. Further, for example, the generation of an unpleasant odor can be suppressed by the bactericidal action of isopropylmethylphenol.
  • the deodorant according to the second embodiment of the present disclosure will be described.
  • the deodorant of the present disclosure is a deodorant for deodorizing the odor of isopropylmethylphenol.
  • the deodorant of the present disclosure can be an aqueous composition, an oily composition, an emulsified product, or a non-emulsified product.
  • the deodorant according to the second embodiment contains the above-mentioned (A) first component.
  • the first component (A) for example, at least one selected from the group of compounds shown in Table 1 can be mentioned.
  • the first component preferably contains at least one of the components (A1), (A4), and (A8).
  • the content of the first component (A) is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and more preferably 1% by mass or more, based on the mass of the deodorant. More preferred. If the content of the first component is less than 0.1% by mass, a sufficient deodorizing effect on the isopropylmethylphenol odor cannot be obtained.
  • the content of the first component can be 2% by mass or less, 1.5% by mass or less, 1% by mass or less, or 0.5% by mass or less with respect to the mass of the deodorant.
  • the first component contains at least one selected from the group consisting of components (A9), (A11), (A12), (A16), (A20) and (A21), for example, the first component is , 0.1% by mass or more, or 0.2% by mass or more with respect to the mass of the deodorant.
  • the first component is the component (A2), (A3), (A5), (A6), (A7), (A10), (A15), (A17), (A18), (A19), (A22) and
  • the first component shall be 0.5% by mass or more or 0.7% by mass or more with respect to the mass of the deodorant. Can be done.
  • the first component contains at least one selected from the group consisting of components (A1), (A4), (A8), (A13), and (A14), for example, the first component is a deodorant. It can be 1% by mass or more, or 1.5% by mass or more with respect to the mass of.
  • the content of the second component (B) is preferably 1 ⁇ 10 -4 % by mass or less with respect to the mass of the deodorant, and is preferably 5 ⁇ 10 -5 % by mass. % Or less is more preferable, and substantially 0% by mass (no content) is further preferable. (B) If at least one of the second components is present in an amount of more than 1 ⁇ 10 -4 % by mass, the scent of the second component (B) becomes an unpleasant odor in combination with the odor of isopropylmethylphenol.
  • the odor of isopropylmethylphenol can be effectively deodorized.
  • the third embodiment a method of applying the deodorant according to the second embodiment, which is a method of deodorizing the isopropylmethylphenol odor, will be described.
  • the method according to the third embodiment includes a first step of applying isopropylmethylphenol to the first region.
  • the first step can be a step of applying the isopropylmethylphenol-containing composition to the skin.
  • the method according to the third embodiment includes a second step of applying the deodorant according to the second embodiment to the second region.
  • the deodorant according to the second embodiment can be applied to at least one of the skin and clothes. At least a portion of the second region can overlap with the odor and range of isopropylmethylphenol.
  • the second region can be a region closer to the nose than the first region.
  • Either the first step or the second step may come first. From the viewpoint of the deodorizing effect, it is preferable to perform the second step after performing the first step.
  • the deodorant according to the second embodiment can be applied to deodorize the isopropylmethylphenol odor.
  • the skin external preparation composition according to the first embodiment and the deodorant according to the second embodiment of the present disclosure include other components such as water, water-soluble alcohol, oily component, as long as the effects of the present disclosure are not impaired.
  • water used for cosmetics, quasi-drugs, etc. can be used, and for example, purified water, ion-exchanged water, tap water, etc. can be used.
  • water-soluble alcohol examples include lower alcohols, polyhydric alcohols, polyhydric alcohol polymers, dihydric alcohol alkyl ethers, dihydric alcohol alkyl ethers, dihydric alcohol ether esters, glycerin monoalkyl ethers, and sugar alcohols. At least one selected from monosaccharides, oligosaccharides, polysaccharides and derivatives thereof and the like can be mentioned.
  • Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.
  • polyhydric alcohol examples include divalent alcohols (eg, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, and the like.
  • divalent alcohols eg, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, and the like.
  • Divalent alcohol alkyl ethers eg, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl) Ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol Cole butyl ether, etc.); Dihydric alcohol ether esters (eg, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate,
  • monosaccharides examples include trisaccharides (eg, D-glycerylaldehyde, dihydroxyacetone, etc.), tetrasaccharides (eg, D-erythrose, D-erythrose, D-treose, erythritol, etc.), and the like.
  • Five-carbon sugars eg, L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-librose, D-xylrose, L- Xylrose, etc.
  • Deoxy sugar eg, D-glucose, D-talose, D-psicos, D-galactose, D-fructouse, L-galactose, L- Mannos, D-tagatos, etc.
  • arabinose eg, aldoheptose, heptulose, etc.
  • octacarbonate eg, octulose, etc.
  • deoxy sugar eg, 2-deoxy-D-ribose, etc.
  • amino sugars eg, D-glucosamine, D-galactosamine, sialic acid, amino
  • oligosaccharide for example, at least one selected from sucrose, guntianose, umbelliferose, lactose, planteos, isolikunoses, ⁇ , ⁇ -trehalose, raffinose, lycnoses, umbilicin, stachyose, velvascours and the like. Can be mentioned.
  • polysaccharides include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, Arabic gum, heparan sulfate, hyaluronic acid, tragant gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guagam, dextran, and keratosulfate. , Locust bean gum, succinoglucan, caronic acid and the like.
  • Examples of other polyols include at least one selected from polyoxyethylene methylglucoside (Glucam E-10), polyoxypropylene methylglucoside (Glucam P-10), and the like.
  • oily component for example, liquid fats and oils, solid fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils and the like can be used.
  • Liquid fats and oils include, for example, avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern ka oil, castor oil, flaxseed oil. , Saflower oil, cotton seed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnamon oil, Japanese millet oil, jojoba oil, germ oil, triglycerin and the like.
  • solid fats and oils examples include coconut oil, palm oil, horse fat, hardened palm oil, palm oil, beef tallow, sheep fat, hardened beef tallow, palm kernel oil, pork fat, beef tallow, mokuro kernel oil, hardened oil, and cow.
  • Examples include leg tallow, mokuro, and hardened coconut oil.
  • waxes examples include honeydew, candelilla wax, cotton wax, carnauba wax, baby wax, ibotarou, whale wax, montan wax, lanolin, lanolin, capoc wax, lanolin acetate, liquid lanolin, sugar cane, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin. , Jojobaro, hard lanolin, cellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether and the like.
  • hydrocarbon oil examples include liquid paraffin, ozokerite, squalane, pristane, paraffin, selecin, squalene, petrolatum, microcrystalline wax and the like.
  • Higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylene acid, tall acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid ( DHA) and the like.
  • Higher alcohols include, for example, linear alcohols (eg, lauryl alcohols, cetyl alcohols, stearyl alcohols, behenyl alcohols, myristyl alcohols, oleyl alcohols, cetostearyl alcohols, etc.); branched alcohols (eg, monostearyl glycerin ethers (batyl alcohols)). ), 2-Deciltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.) and the like can be used.
  • linear alcohols eg, lauryl alcohols, cetyl alcohols, stearyl alcohols, behenyl alcohols, myristyl alcohols, oleyl alcohols, cetostearyl alcohols, etc.
  • branched alcohols eg, monostearyl glycerin ethers (batyl alcohols)
  • Synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate.
  • Silicone oils include dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, stearoxymethylpolysiloxane, polyether-modified organopolysiloxane, fluoroalkyl-polyoxyalkylene co-modified organopolysiloxane, and alkyl-modified organopolysiloxane.
  • End-modified organopolysiloxane End-modified organopolysiloxane, fluorine-modified organopolysiloxane, amino-modified organopolysiloxane, silicone gel, acrylic silicone, trimethylsiloxysilicicane, silicone RTV rubber, silicone compounds such as cyclopentasiloxane, and the like.
  • the powder is not particularly limited as long as it can be generally used for cosmetic purposes.
  • examples of the powder include inorganic powders (for example, talc, kaolin, mica, silk mica (serisite), white mica, gold mica, synthetic mica, red mica, black mica, lithia mica, fired mica, fired talc, vermiculite, etc.
  • Natural pigments eg, chlorophyll, ⁇ -carotene, etc.
  • Wax powder eg, carnauba wax powder, etc.
  • Starch powder eg, corn starch powder, rice starch powder, etc.
  • anionic surfactants include fatty acid sequels (eg, sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (eg, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (eg, sodium lauryl sulfate, etc.).
  • N-acylsarcosic acid e.g, sodium lauroyl sarcosin, etc.
  • higher fatty acid amide sulfonate e.g, N-stearoyl-N-methyltaurine sodium, etc.
  • Phosphate ester salts POE-oleyl ether phosphate sodium, POE-stearyl ether phosphoric acid, etc.
  • Alkylbenzene sulfonate e.g., sodium di-2-ethylhexyl sulfosuccinate, monolauroy
  • cationic surfactant examples include alkyltrimethylammonium salts (eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (eg, cetylpyridinium chloride, etc.); dialkyldimethylammonium salts (eg, distearyl chloride, etc.).
  • alkyltrimethylammonium salts eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.
  • alkylpyridinium salts eg, cetylpyridinium chloride, etc.
  • dialkyldimethylammonium salts eg, distearyl chloride, etc.
  • Dimethylammonium Dimethylammonium); poly (N, N'-dimethyl-3,5-methylenepiperidinium); alkyl quaternary ammonium salt; alkyldimethylbenzylammonium salt; alkylisoquinolinium salt; dialkylmoriphonium salt; POE -Alkylamine; alkylamine salt; polyamine fatty acid derivative; ammonium alcohol fatty acid derivative; benzalkonium chloride; benzethonium chloride and the like.
  • amphoteric surfactant examples include imidazoline-based amphoteric surfactants (eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazolin sodium, 2-cocoyl-2-imidazolinium hydroki. Side-1-carboxyethyroxy disodium salt, etc.); Betaine-based surfactants (eg, 2-heptadecyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amide betaine) , Sulfobetaine, etc.) and the like.
  • imidazoline-based amphoteric surfactants eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazolin sodium, 2-cocoyl-2-imidazolinium hydroki. Side-1-carboxyeth
  • hydrophilic nonionic surfactant examples include POE-sorbitan fatty acid esters (eg, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.); POE-Solbit fatty acid ester (eg POE-Solbit monolaurate, POE-Solbit monooleate, POE-Solbit pentaoleate, POE-Solbit monostearate, etc.); POE-glycerin fatty acid ester (eg, POE-glycerin mono) POE-monooleates such as stearate, POE-glycerin monoisostearate, POE-glycerin triisostearate, etc.; POE-fatty acid esters (eg, POE-distearate, POE-monodiolate, ethylene glycol distearate, etc.); POE- Al
  • lipophilic nonionic surfactant examples include sorbitan fatty acid esters (eg, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan.
  • sorbitan fatty acid esters eg, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan.
  • Trioleate penta-2-ethylhexylate diglycerol sorbitan, tetra-2-ethylhexylate diglycerol sorbitan, etc.; , ⁇ , ⁇ '-Glycerin pyroglutamate oleate, glycerin malic acid monostearate, etc.); propylene glycol fatty acid ester (for example, propylene glycol monostearate, etc.); cured castor oil derivative; glycerin alkyl ether and the like.
  • thickeners examples include Arabic gum, carrageenan, carrageenan, tragacanth gum, carob gum, quince seed (malmero), casein, dextrin, gelatin, sodium pectinate, sodium alginate, methyl cellulose, ethyl cellulose, carboxymethyl cellulose (CMC), hydroxyethyl cellulose.
  • Hydroxypropyl cellulose polyvinyl alcohol (PVA), polyvinyl methyl ether (PVM), PVP (polypolypyrrolidone), sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guagam, tamarint gum, dialkyldimethylammonium sulfate cellulose, xanthan gum, cay
  • PVA polyvinyl alcohol
  • PVM polyvinyl methyl ether
  • PVP polypolypyrrolidone
  • sodium polyacrylate sodium polyacrylate
  • carboxyvinyl polymer locust bean gum, guagam, tamarint gum, dialkyldimethylammonium sulfate cellulose, xanthan gum
  • cay Examples thereof include aluminum magnesium acid acid, bentonite, hectrite, aluminum magnesium silicate (beagum), laponite, silicic anhydride, taurate-based synthetic polymer, and acrylate-based synthetic polymer.
  • Natural water-soluble polymers include, for example, plant-based polymers (eg, arabic gum, tragacanto gum, galactan, guagam, carob gum, karaya gum, carrageenan, pectin, canten, quince seed (malmero), algae colloid (cassaw extract), starch. (Rice, corn, potato, wheat), glycyrrhizinic acid); Micromolecular macromolecules (eg, xanthan gum, dextran, succinoglucan, purulan, etc.); Animal macromolecules (eg, collagen, casein, albumin, gelatin, etc.), etc. Can be mentioned.
  • plant-based polymers eg, arabic gum, tragacanto gum, galactan, guagam, carob gum, karaya gum, carrageenan, pectin, canten, quince seed (malmero), algae colloid (cassaw extract), starch. (Rice, corn, potato, wheat), glycyr
  • Examples of the semi-synthetic water-soluble polymer include starch-based polymers (for example, carboxymethyl starch, methyl hydroxypropyl starch, etc.); cellulose-based polymers (methyl cellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, etc.). , Hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, etc.); Examples of alginic acid-based polymers (for example, sodium alginate, propylene glycol alginate, etc.) and the like.
  • starch-based polymers for example, carboxymethyl starch, methyl hydroxypropyl starch, etc.
  • cellulose-based polymers methyl cellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, etc.
  • Examples of the synthetic water-soluble polymer include vinyl polymers (for example, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer, etc.); polyoxyethylene polymers (for example, polyethylene glycol 20,000, 40). 000, 60,000 polyoxyethylene polyoxypropylene copolymers, etc.); Acrylic polymers (eg, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); Polyethyleneimine; Cationic polymers and the like.
  • vinyl polymers for example, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer, etc.
  • polyoxyethylene polymers for example, polyethylene glycol 20,000, 40). 000, 60,000 polyoxyethylene polyoxypropylene copolymers, etc.
  • Acrylic polymers eg, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.
  • Polyethyleneimine Cationic
  • Moisturizers include, for example, polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, martitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate. , Sodium lactate, bile acid salt, dl-pyrrolidone carboxylate, alkylene oxide derivative, short chain soluble collagen, diglycerin (EO) PO adduct, Izayoi rose extract, sardine extract, melilot extract and the like.
  • EO diglycerin
  • the film agent examples include an anionic film agent (for example, (meth) acrylic acid / (meth) acrylic acid ester copolymer, methyl vinyl ether / maleic anhydride hyperpolymer, etc.), and a cationic film agent (for example, cation).
  • an anionic film agent for example, (meth) acrylic acid / (meth) acrylic acid ester copolymer, methyl vinyl ether / maleic anhydride hyperpolymer, etc.
  • a cationic film agent for example, cation.
  • nonionic film agent for example, polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl acetate, polyacrylic acid ester copolymer, (meth) Acrylamide, high molecular weight silicone, silicone resin, trimethylsiloxysilicic acid, etc.
  • oil-soluble ultraviolet absorber examples include benzoic acid-based ultraviolet absorbers (for example, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxyPABA.
  • PABA paraaminobenzoic acid
  • PABA monoglycerin ester N, N-dipropoxy PABA ethyl ester
  • N, N-diethoxyPABA examples include benzoic acid-based ultraviolet absorbers (for example, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxyPABA.
  • Ethyl ester N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester, diethylaminohydroxybenzoyl hexyl benzoate, etc.); Anthranilic acid-based ultraviolet absorber (for example, homomentyl- N-Acetylanthranilate, etc.); Salicylic acid-based ultraviolet absorbers (eg, ethylhexyl salicylate, amylsalicylate, menthylsalicylate, homomentylsalicylate, octylsalicylate, phenylsalicylate, benzylsalicylate, p-isopropanol phenylsalicylate, homosalate, etc.); Acid-based UV absorbers (eg, octylmethoxycinnamate, ethyl-4-isopropy
  • water-soluble ultraviolet absorber examples include a benzophenone-based ultraviolet absorber (for example, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.) and a benzilidenshounow-based ultraviolet absorber (benzilidenshounow sulfonic acid, terephthalili). Denjishono sulfonic acid, etc.), phenylbenzoimidazole-based ultraviolet absorber (phenylbenzimidazole sulfonic acid, etc.) and the like can be mentioned.
  • a benzophenone-based ultraviolet absorber for example, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.
  • benzilidenshounow-based ultraviolet absorber benzilidenshounow sulfonic acid, terephthalili.
  • Denjishono sulfonic acid, etc. phenylbenzoimidazole-based ultraviolet absorber
  • metal ion sequestering agent examples include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate.
  • Sodium citrate sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate and the like.
  • amino acids examples include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like.
  • amino acid derivative examples include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl ⁇ -alanine sodium, glutathione, pyrrolidone carboxylic acid and the like.
  • organic amine examples include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol and the like. Can be mentioned.
  • polymer emulsion examples include an acrylic resin emulsion, an ethyl polyacrylate emulsion, an acrylic resin solution, a polyacrylic alkyl ester emulsion, a polyvinyl acetate resin emulsion, and a natural rubber latex.
  • vitamins examples include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin and the like.
  • antioxidants examples include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.
  • antioxidant aid examples include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, ethylenediamine tetraacetic acid and the like.
  • compoundable ingredients include, for example, preservatives (ethylparaben, butylparaben, chlorphenesin, phenoxyethanol, etc.); anti-inflammatory agents (eg, glycyrrhizinic acid derivative, glycyrrhetinic acid derivative, salicylic acid derivative, hinokithiol, zinc oxide, allantin, etc.) ); Whitening agents (eg, placenta extract, yukinoshita extract, albutin, etc.); Various extracts (eg, sardines, auren, shikon, shakuyaku, assembly, birch, sage, biwa, carrot, aloe, zegna oyster, iris, grape , Yokuinin, Hechima, Yuri, Saffron, Senkyu, Shokyo, Otogirisou, Ononis, Garlic, Togarashi, Chimpi, Touki, Seaweed, etc.), Activators (eg, Royal Je
  • compositions of the present disclosure include caffeine, tannin, verapamiru, tranexamic acid and derivatives thereof, various crude drug extracts such as licorice, carin, ichiyakuso, tocopherol acetate, glycyrrhizic acid, glycyrrhizinic acid and derivatives thereof or salts thereof.
  • Drugs, whitening agents such as vitamin C, magnesium ascorbic acid phosphate, ascorbic acid glucoside, arbutin, and kodiic acid, amino acids such as arginine and lysine, and derivatives thereof can also be appropriately contained.
  • the method for producing the external skin preparation composition and the deodorant of the present disclosure will be described.
  • the skin external preparation composition and the deodorant of the present disclosure can be prepared by a generally known method without being made into a specific method.
  • a skin external preparation composition and a deodorant can be prepared by mixing each of the above components.
  • the skin external preparation composition and deodorant of the present disclosure may be difficult to be directly specified by the composition or the like, or may not be practical. In such a case, the external preparation composition for skin and the deodorant of the present disclosure should be allowed to be specified by the manufacturing method thereof.
  • Isopropylmethylphenol (trade name: Biosol (registered trademark) Osaka Kasei Co., Ltd.) was dissolved in dipropylene glycol to prepare a 10% by mass solution of isopropylmethylphenol. The concentration of each compound is adjusted so that the scent of each compound has the same intensity, and this solution is scented. Sensory evaluation was performed. The evaluation criteria for the masking effect and the harmonizing effect are shown below. Table 3 shows the evaluation results of the first component shown in Table 1.
  • Table 4 shows the evaluation results of the second component shown in Table 2.
  • the amount of the fragrance component added in Tables 3 and 4 is a mass ratio to 1 part by mass of isopropylmethylphenol.
  • the masking effect of the first components (A1) to (A23) it was confirmed that the first components (A1) to (A23) have a masking effect on the isopropylmethylphenol odor.
  • the components (A1) to (A9) and (A16) to (A19) had a high masking effect.
  • the harmonizing effect of the first components (A1) to (A23) it was confirmed that at least the components (A1) to (A23) had no adverse effect on the harmonizing effect. In particular, it was confirmed that the components (A1) to (A15) reduce the unpleasantness of the isopropylmethylphenol odor, and that they have both a masking effect and a harmonizing effect. From this, it is considered that the first components (A1) to (A23) have a deodorizing effect of the isopropylmethylphenol odor.
  • Ingredients (A1), (A3), and (A17) are woody fragrances.
  • Ingredients (A2), (A4) to (A7), (A10) and (A20) are citrus-based fragrances. From this, it is considered that the compound having a citrus-based or woody-based scent is particularly effective for deodorizing the isopropylmethylphenol odor.
  • Ingredients (B11), (B12), (B23) and (B24) are musk-based fragrances.
  • Ingredients (B3) and (B13) are aldehyde-based fragrances. From this, it is considered that compounds having a musk-based or aldehyde-based scent should not be used for deodorizing the isopropylmethylphenol odor.
  • the application examples of the deodorant of the present disclosure are not limited to the following formulation examples.
  • the unit of the content of each component shown in the table is mass%.
  • [Appendix 2] A method of applying the skin external preparation composition of the present disclosure as an antiperspirant or a deodorant.
  • [Appendix 3] In the first step of applying isopropylmethylphenol to the first region, An isopropylmethylphenol odor that includes a second step of applying the deodorant of the present disclosure to a second region, and at least a portion of the second region overlaps with the odor of isopropylmethylphenol. Deodorant method.
  • [Appendix 4] The method of the appendix, wherein the isopropylmethylphenol is applied to the skin in the first step.
  • [Appendix 5] The method according to the appendix, wherein the fragrance is applied to the skin in the second step.
  • [Appendix 6] The method according to the appendix, wherein the second step is performed after the first step is performed.
  • the skin external preparation composition, deodorant, and isopropylmethylphenol odor deodorizing method of the present disclosure can be applied to, for example, cosmetics, cleansing agents, etc. applied to the skin.
  • the skin external preparation composition of the present disclosure includes a deodorant, an antiperspirant, a deodorant, a sunscreen cosmetic, a skin care agent, a make-up cosmetic, a hair conditioner, a hair restorer, a hair growth agent, a scalp care agent, and a cleaning agent. It can be applied to charges, therapeutic agents, etc.

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Abstract

La présente invention concerne une composition d'agent externe pour la peau qui comprend de l'isopropylméthylphénol, et 1 × 10-5 parties en masse à 5 × 10-1 parties en masse d'un premier composant pour 1 partie en masse de l'isopropylméthylphénol. Le premier composant comprend au moins une substance choisie dans le groupe constitué des suivants : 7-acétyl-1,2,3,4,5,6,7,8-octahydro-1,1,6,7-tétraméthylnaphtalène, huile de chaux, limonène, α-terpinène, huile de citron, huile de peau d'orange amère, linalol, damascénone, huile de bergamote, salicylate de cis-3-hexényle, 2-méthylbutyrate d'éthyle, aldéhyde hexylcinnamique, éthyl-linalol, géraniol, ambroxyde et éthyl-triméthylcyclopentényl-buténol.
PCT/JP2021/015072 2020-04-23 2021-04-09 Composition d'agent externe pour la peau et déodorant WO2021215274A1 (fr)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004359602A (ja) * 2003-06-04 2004-12-24 Shiseido Co Ltd 皮膚外用剤
JP2006182662A (ja) * 2004-12-27 2006-07-13 Lion Corp 歯磨剤組成物
JP2006225306A (ja) * 2005-02-17 2006-08-31 Kao Corp 入浴剤組成物
JP2007332355A (ja) * 2006-05-18 2007-12-27 Lion Corp 洗浄剤組成物
JP2016064996A (ja) * 2014-09-24 2016-04-28 花王株式会社 皮膚化粧料

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JP2004359602A (ja) * 2003-06-04 2004-12-24 Shiseido Co Ltd 皮膚外用剤
JP2006182662A (ja) * 2004-12-27 2006-07-13 Lion Corp 歯磨剤組成物
JP2006225306A (ja) * 2005-02-17 2006-08-31 Kao Corp 入浴剤組成物
JP2007332355A (ja) * 2006-05-18 2007-12-27 Lion Corp 洗浄剤組成物
JP2016064996A (ja) * 2014-09-24 2016-04-28 花王株式会社 皮膚化粧料

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