WO2021196464A1 - 清洗装置 - Google Patents

清洗装置 Download PDF

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Publication number
WO2021196464A1
WO2021196464A1 PCT/CN2020/104910 CN2020104910W WO2021196464A1 WO 2021196464 A1 WO2021196464 A1 WO 2021196464A1 CN 2020104910 W CN2020104910 W CN 2020104910W WO 2021196464 A1 WO2021196464 A1 WO 2021196464A1
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WO
WIPO (PCT)
Prior art keywords
magnetic
sliding
screw
rod
support plate
Prior art date
Application number
PCT/CN2020/104910
Other languages
English (en)
French (fr)
Inventor
周史良
韩奎亮
张西强
孙永程
张海洋
Original Assignee
北京美联泰科生物技术有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 北京美联泰科生物技术有限公司 filed Critical 北京美联泰科生物技术有限公司
Publication of WO2021196464A1 publication Critical patent/WO2021196464A1/zh
Priority to US17/578,456 priority Critical patent/US20220134388A1/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B1/00—Cleaning by methods involving the use of tools
    • B08B1/30—Cleaning by methods involving the use of tools by movement of cleaning members over a surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • B08B3/041—Cleaning travelling work
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • C12M1/3446—Photometry, spectroscopy, laser technology
    • C12M1/3461—Bio- or chemi-luminescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/40—Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips

Definitions

  • the invention relates to the technical field of medical equipment, in particular to a cleaning device.
  • the luminescence immunoassay analyzer combines the micro-magnetic bead solid-phase carrier platform and the chemiluminescence detection technology. It not only has the characteristics of high sensitivity, accurate results and automation of magnetic particle chemiluminescence detection, but also has the characteristics of fast detection, simple operation and easy to carry, so it is particularly It is suitable for POCT (point of care-testing) applications such as rapid outpatient testing and home self-testing.
  • POCT point of care-testing
  • Micro-magnetic beads are the carrier for test solution analysis.
  • the micro-magnetic beads need to be cleaned before the final luminescence data can be collected through the measurement and reading module for accurate measurement and reading. Therefore, the cleaning of micro-magnetic beads is a necessary guarantee for the accuracy of analytical data.
  • the purpose of the present invention is to provide a cleaning device which has a high degree of automation, stable operation of the equipment, good cleaning effect and high cleaning efficiency.
  • a cleaning device includes an inverted U-shaped frame body.
  • the frame body includes a horizontal beam.
  • the two ends of the beam are respectively connected with vertical beams.
  • a movable first driving mechanism, the cleaning mechanism includes a magnetic sleeve assembly and a magnetic rod sleeved therewith, the upper end of the magnetic rod is connected with a second driving mechanism for driving the magnetic sleeve assembly to move up and down;
  • the magnetic sleeve assembly includes a magnetic sleeve seat, a magnetic sleeve and a magnetic rod.
  • a plurality of vertical through holes are opened on the bearing plate.
  • a tubular magnetic sleeve with an opening is placed on the magnetic rod, and a through hole and a magnetic sleeve seat are respectively penetrated downward from the magnetic rod and sleeved in the magnetic sleeve;
  • the first driving mechanism includes a first pallet, the first pallet is located on the rear side of the bearing plate and is fixedly connected to the first pallet, a horizontal support plate is provided under the first pallet, and the support plate is fixed to two vertical beams The upper end of the beam is fixedly connected to a first motor which is arranged vertically, and the output end of the first motor is connected to the first lead screw through the beam, and the first support plate is fixedly connected to the first lead screw
  • a first guide mechanism for guiding the up and down movement of the first support plate is also provided on the first support plate;
  • the second driving mechanism includes a second pallet arranged above the first pallet, the rear side of the first pallet is fixedly connected to a vertical motor frame, and the upper end of the motor frame is fixed with a vertical second motor, The output end of the second motor is connected to a second vertical lead screw, a second lead screw nut adapted to the second lead screw is fixedly connected to the second support plate, and a second lead screw nut is fixedly connected to the second support plate.
  • the first motor and the second motor are connected to a PLC that coordinates the movement of the two.
  • the first motor can drive the first supporting plate, the carrying plate, the clamping plate and the second supporting plate to move up and down together through the first screw.
  • the rotation of the first motor drives the first screw to drive the first pallet and the second pallet to move down together
  • the magnetic sleeve seat is first nested with the magnetic sleeve in the reagent strip, and then the second motor rotates through the second
  • the lead screw drives the second pallet to move up and down
  • the fixedly connected card plate on the second pallet drives the magnetic rod to move up and down, so that the lower end of the magnetic rod is separated from the bottom of the magnetic sleeve or close to the bottom of the magnetic sleeve, and the magnetic rod abuts against the magnetic sleeve Bottom or detached from the bottom of the magnetic sleeve, so that the micro-magnetic beads in the cleaning hole on the reagent strip are attracted by the magnetic rod or separated from the magnetic rod to achieve the purpose of cleaning the micro-magnetic beads.
  • the present invention is further configured as follows: the magnetic rod is rod-shaped, the lower part is a magnetic part, the upper part is provided with an outwardly protruding retaining ring, and the top end is provided with a vertical internal threaded hole.
  • the magnetic part at the lower part of the magnet bar can attract the micro-magnetic beads, and the retaining ring and internal thread can be clamped and fixed with the card board, so that the magnet bar can move up and down with the card board.
  • the card board is provided with a plurality of stepped grooves with openings facing the second support plate, the steps at the lower end of the stepped grooves are provided with clamping holes adapted to the magnetic rod, and the upper end of the magnetic rod penetrates upwards
  • the clamping hole and the retaining ring abut against the lower end of the clamping plate, and the internal threaded hole is threadedly connected with the fastener.
  • the retaining ring of the magnetic bar can be pressed against the lower end of the card board, and the fastener fixes the upper end of the magnetic bar on the upper end of the stepped groove, so that the magnetic bar and the card board are firmly connected together.
  • the stick can move synchronously with the card board.
  • the first guide mechanism includes first sliding holes on the first support plate on both sides of the first screw, and each of the first sliding holes is sleeved with a vertical first sliding hole.
  • the two ends of each first sliding rod are respectively fixedly connected to the cross beam and the supporting plate
  • the second guide mechanism includes second sliding holes on the second supporting plate on both sides of the second screw, each The second sliding holes are respectively sleeved with vertical second sliding rods, and two ends of each second sliding rod are respectively fixedly connected with the cross beam and the supporting plate.
  • the first pallet can move up and down under the guidance of the first sliding rods on both sides
  • the second pallet can move up and down under the guidance of the second sliding rods on both sides, ensuring the first The smooth running of the pallet and the second pallet.
  • the present invention is further provided as follows: a coaxial first sliding sleeve is fixed on the first sliding hole, and the first sliding sleeve is slidably connected with the first sliding rod; and the second sliding hole is fixed with a coaxial first sliding sleeve.
  • the second sliding sleeve is slidably connected with the second sliding rod.
  • the first sliding rod slides in the first sliding sleeve, which reduces the friction and improves the smoothness of the first pallet running up and down; the second sliding rod slides in the second sliding sleeve, which also reduces The friction is reduced, and the smooth running of the second pallet is improved.
  • the present invention is further provided that: the other end of the first lead screw and the other end of the second lead screw are both free ends.
  • the other ends of the first screw and the second screw are both free ends, which can reduce the volume of the equipment, facilitate installation and maintenance, and improve the reliability of the operation of the equipment.
  • the present invention is further configured as follows: the first pallet is provided with a second sliding rod and a second screw respectively with a relief hole; the second pallet is respectively provided with a first sliding rod and a first screw Give way.
  • the provision of the relief hole can ensure the smooth installation of the first slide bar, the second slide bar, the first screw and the second screw and the non-interference with the first pallet and the second pallet.
  • the first pallet and the second pallet can move up and down normally.
  • each of the through holes, cleaning mechanisms and step grooves on the bearing plate is provided with eight.
  • 8 sets of cleaning mechanisms are arranged on the bearing plate.
  • the first motor drives the first pallet and the second pallet to move up and down synchronously.
  • 8 cleaning mechanisms can be moved up and down at a time. The cleaning of the micro-magnetic beads in the 8 reagent strips greatly improves the cleaning efficiency and the production efficiency.
  • the cleaning mechanism can move up and down synchronously with the first pallet and the second pallet, and the second drive mechanism can also make the magnetic rod relatively close to the magnetic sleeve. Or move away, so that the lower end of the outer side of the magnetic sleeve can attract the micro-magnetic beads, and the micro-magnetic beads on the lower end of the outer side of the magnetic sleeve can be separated from the magnetic sleeve, so as to achieve the purpose of cleaning the micro-magnetic beads.
  • the device has a high degree of automation and stable operation. The cleaning effect is good and the cleaning efficiency is high.
  • the first and second pallets can move up and down with high precision and run smoothly.
  • Figure 1 is a schematic front view of the present invention
  • FIG. 2 is a schematic diagram of the structure of the present invention with the card board removed;
  • Figure 3 is a schematic diagram of the rear view of the present invention.
  • Figure 4 is a schematic diagram of the structure of the card board of the present invention.
  • Figure 5 is an exploded view of the cleaning mechanism of the present invention.
  • Fig. 6 is a schematic diagram of the mechanism of the reagent strip holder and reagent strip of the present invention.
  • the second driving mechanism 51, the first Two pallets; 52, motor frame; 53, second motor; 54, second screw; 55, second screw nut; 56, second guide mechanism; 561, second sliding hole; 562, second sliding Rod; 563, second sliding sleeve; 57, card plate; 571, step groove; 572, snap hole; 6, give way hole; 7, reagent strip holder; 8, reagent strip; 81, reaction well; 82, section One cleaning hole; 83, the second cleaning hole; 84, the third cleaning hole; 85, the fourth cleaning hole; 86, the magnetic sleeve placement hole.
  • a cleaning device includes an inverted U-shaped frame body 1.
  • the frame body 1 includes a horizontal beam 11.
  • the two ends of the beam 11 are respectively connected to vertical beams 12 perpendicular to it.
  • the horizontal bearing plate 3 of the mechanism 2 and the first driving mechanism 4 that can drive the bearing plate 3 to move up and down.
  • the cleaning mechanism 2 includes a magnetic sleeve assembly 21 and a magnetic bar 22 sleeved with it.
  • the upper end of the magnetic bar 22 is connected to drive its relative magnetic
  • the second driving mechanism 5 for the set assembly 21 to move up and down.
  • the magnetic sleeve assembly 21 includes a magnetic sleeve seat 211, a magnetic sleeve 212, and a magnetic rod 22.
  • a plurality of vertical through holes 31 are provided on the bearing plate 3.
  • the tubular magnetic sleeve 212 with the upper opening is nested, and the magnetic rod 22 respectively penetrates the through hole 31 and the magnetic sleeve seat 211 downward and is sleeved in the magnetic sleeve 212.
  • the first driving mechanism 4 includes a first support plate 41, the first support plate 41 is located on the rear side of the bearing plate 3 and is fixedly connected to it.
  • a horizontal support plate 42 is provided under the first support plate 41, and the support plate 42 is fixed to the two vertical beams 12
  • the upper end of the beam 11 is fixedly connected to the first motor 43 which is arranged vertically.
  • the output end of the first motor 43 is connected to the vertical first screw 44 through the beam 11, and the first support plate 41 is fixedly connected to the first screw 44 is matched with the first screw nut 45, and the first support plate 41 is also provided with a first guide mechanism 46 for guiding it to move up and down.
  • the second driving mechanism 5 includes a second pallet 51 arranged above the first pallet 41, the rear side of the first pallet 41 is fixedly connected to a vertical motor frame 52, and the upper end of the motor frame 52 is fixed with a vertical second motor 53 , The output end of the second motor 53 is connected to the vertical second lead screw 54, the second support plate 51 is fixedly connected to the second lead screw nut 55 that is adapted to the second lead screw 54, and the second support plate 51 is also A second guide mechanism 56 for guiding the vertical movement is provided, and the front side of the second pallet 51 is fixedly connected with a clamping plate 57 for clamping the magnet bar 22.
  • the forward and reverse rotations and running time of the first motor 43 and the second motor 53 are coordinated and controlled by the PLC.
  • both the first screw 44 and the second screw 54 use T-shaped screws.
  • the first motor 43 can drive the first supporting plate 41, the supporting plate 3, the clamping plate 57 and the second supporting plate 51 to move up and down together through the first screw 44.
  • the first motor 43 rotates and the first pallet 41 and the second pallet 51 move downwards synchronously through the first screw 44, the magnetic sleeve seat 211 is first nested with the magnetic sleeve 212 in the reagent strip 8, and then , The second motor 53 rotates, and the second pallet 51 is driven to move up and down through the second screw 54.
  • the clamp plate 57 fixedly connected to the second pallet 51 drives the magnetic bar 22 to move up and down, so that the lower end of the magnetic bar 22 is separated
  • the working states of the first motor 43 and the second motor 53 are coordinated through PLC control.
  • the magnetic rod 22 is rod-shaped, and its lower part is a magnetic part.
  • the magnetic part at the lower part of the magnetic rod 22 can attract the micro-magnetic beads.
  • the top of 22 is provided with a vertical internal threaded hole 222, and the retaining ring 221 and internal thread can be clamped and fixed with the clamping plate 57, so that the magnetic rod 22 can follow the clamping plate 57 to move up and down.
  • the card plate 57 is provided with a plurality of stepped grooves 571 with openings facing the second support plate 51.
  • the steps at the lower end of the stepped grooves 571 are provided with clamping holes 572 adapted to the magnet bar 22, and the upper end of the magnet bar 22 penetrates upward.
  • a clamping hole 572 is provided and the retaining ring 221 abuts against the lower end of the clamping plate 57.
  • the internal threaded hole 222 is threadedly connected to the fastener 223.
  • the rod 22 and the card board 57 are firmly connected together, and the magnetic rod 22 can move up and down synchronously with the card board 57.
  • the first guide mechanism 46 of this embodiment includes first sliding holes 461 on the first support plate 41 located on both sides of the first screw 44, and each first sliding hole 461 is sleeved with a vertical first sliding rod. 462.
  • the two ends of each first sliding rod 462 are respectively fixedly connected to the cross beam 11 and the support plate 42;
  • the second guide mechanism 56 includes second sliding holes 561 on the second support plate 51 located on both sides of the second screw 54
  • Each second sliding hole 561 is sleeved with a vertical second sliding rod 562.
  • the two ends of each second sliding rod 562 are respectively fixedly connected to the beam 11 and the supporting plate 42;
  • the first sliding rods 462 on both sides can move up and down under the guidance of the second sliding rods 562 on both sides of the second pallet 51. This ensures that the first pallet 41 and the second pallet 51 can move up and down under the guidance of the second sliding rods 562 on both sides. Stability of running up and down.
  • a coaxial first sliding sleeve 463 is fixed on the first sliding hole 461, and the first sliding sleeve 463 and the first sliding rod 462 are fixed. Sliding connection; a coaxial second sliding sleeve 563 is fixed on the second sliding hole 561, and the second sliding sleeve 563 is slidably connected with the second sliding rod 562.
  • the other end of the first screw 44 and the other end of the second screw 54 are both set as free ends, which can reduce the volume of the equipment, facilitate installation and maintenance, and improve the reliability of the operation of the equipment.
  • the first pallet 41 The second sliding rod 562 and the relief hole 6 of the second screw 54 are respectively provided on the upper part, and the first sliding rod 462 and the relief hole 6 of the first screw 44 are respectively provided on the second support plate 51.
  • the bearing plate 3 there are 8 through holes 31, cleaning mechanisms 2 and step grooves 571 on the bearing plate 3, and 8 sets of cleaning mechanisms 2 are provided on the bearing plate 3.
  • the first motor 43 can drive 8 sets of cleaning mechanisms 2.
  • the first pallet 41 and the second pallet 51 move up and down, and the second motor 53 drives the 8 magnet bars 22 corresponding to the magnetic sleeve 212 to move up and down at the same time, so that 8 cleaning mechanisms 2 can be performed at the same time.
  • the cleaning of the micro-magnetic beads in the 8 reagent strips 8 greatly improves the cleaning efficiency and improves the production efficiency.
  • FIG. 6 is a schematic diagram of the structure of eight reagent strips 8 placed on the reagent strip rack 7.
  • the magnetic sleeve 212 is sleeved on the magnetic sleeve base 211.
  • the first motor 43 rotates forward, the first screw 44 drives the first pallet 41, the bearing plate 3, the card plate 57 and the second pallet 51 to move downward synchronously, so that the magnetic sleeve seat 211 and the magnetic sleeve in the reagent strip 8
  • the magnetic sleeve 212 in the placement hole 86 is nested.
  • the first motor 43 is reversed, and the first supporting plate 41, the supporting plate 3, the card plate 57 and the second supporting plate 51 are driven to move upwards synchronously through the first screw 44, the reagent strip rack 7 is moved, and the reagent strip 8 is
  • the reaction hole 81 is placed directly below the magnetic sleeve 212 to make the first motor 43 rotate forward again, and the first screw 44 drives the first support plate 41, the carrying plate 3, the card plate 57 and the second support plate 51 to move downwards synchronously ,
  • the magnetic sleeve 212 is immersed in the reaction liquid in the reaction hole 81, the second motor 53 rotates forward, and the second screw 54 drives the first support plate 41, the clamping plate 57, and the magnetic rod 22 to move downwards, so that the magnetic rod 22 and The lower end of the magnetic sleeve 212 abuts, because the lower part of the magnetic rod 22 is magnetic, the micro-magnetic beads in the reaction solution in the reaction hole 81 are attracted to the outer wall of the
  • the first motor 43 is reversed, and the first screw 44 drives the first pallet 41, the supporting plate 3, the card plate 57, and the second pallet 51 to move upwards synchronously, and moves the reagent strip rack 7 so that the first pallet on the reagent strip 8
  • the cleaning hole 82 is located directly below the magnetic sleeve 212, the first motor 43 rotates forward, and the first screw 44 drives the first support plate 41, the carrying plate 3, the card plate 57, and the second support plate 51 to move downward synchronously to make the suction
  • the second motor 53 reverses, and the second screw 54 drives the first support plate 41, the clamping plate 57, and the magnetic rod 22 to move upwards, so that the magnetic rod 22 is far away
  • the micro-magnetic beads originally adsorbed to the lower end of the outer side of the magnetic
  • the first motor 43 rotates forward and reverse alternately, driving the magnetic sleeve 212 in and out of the cleaning liquid in the first cleaning hole 82, so that the magnetic sleeve 212 is in the first cleaning hole 82.
  • the micro-magnetic beads that were originally adsorbed on the magnetic sleeve 212 will all be scattered into the cleaning liquid, and the second motor 53 will rotate forward again to make The magnetic bar 22 abuts against the lower end of the magnetic sleeve 212, and under the action of the magnetic force, the micro-magnetic beads are attracted to the lower end of the outer side of the magnetic sleeve 212, and then the second motor 53 reverses again, causing the magnetic bar 22 to move upward and away from the magnetic sleeve 212 At the lower end, after the above process, the micromagnetic beads are all scattered into the cleaning liquid in the first cleaning hole 82. After the above cleaning process is repeated several times, the cleaning of the micromagnetic beads in the first cleaning hole 82 is completed.
  • the second motor 53 is rotated forward to make the magnetic rod 22 abut against the lower end of the magnetic sleeve 212.
  • the micro-magnetic beads are attracted to the lower end of the outer side of the magnetic sleeve 212, and then the first motor 43 reverses to make the belt
  • the magnetic sleeve 212 of the micro-magnetic beads moves upward to move the reagent strip rack 7 so that the second cleaning hole 83 on the reagent strip 8 is located directly under the magnetic sleeve 212, and the first motor 43 rotates forward to make the magnetic micro-beads
  • the sleeve 212 is immersed in the second cleaning hole 83, and the cleaning process in the first cleaning hole 82 is repeated.
  • the magnetic sleeve 212 with micro-magnetic beads is immersed in the third cleaning hole 84, and after the cleaning process in the first cleaning hole 82 is repeated, the first motor 43 reverses to lift the magnetic sleeve 212 with micro-magnetic beads, Move the reagent strip rack 7 so that the fourth cleaning hole 85 on the reagent strip 8 is located directly under the magnetic sleeve 212, and then immerse the magnetic sleeve 212 with micro-magnetic beads into the cleaning solution in the fourth cleaning hole 85.
  • the motor 53 reverses, and the magnetic rod 22 is far away from the lower end of the magnetic sleeve 212.
  • the micro-magnetic beads lose the magnetic attraction of the magnetic rod 22 and are scattered into the cleaning liquid in the fourth cleaning hole under the action of gravity.
  • the motor 43 reverses, and the first screw 44 drives the first pallet 41, the carrier plate 3, the card plate 57 and the second pallet 51 to move upwards synchronously.
  • the cleaning of the micromagnetic beads is completed, and the reagents on the reagent strip rack 7 are moved.
  • Article 8 carries out the test work of the next process.

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Abstract

一种清洗装置，包括倒U形架体（1），架体（1）包括水平横梁（11），横梁（11）两端分别连接与其垂直的竖梁（12），架体（1）内设置有承载清洗机构（2）的水平承载板（3）以及可带动承载板（3）上下移动的第一驱动机构（4），清洗机构（2）包括磁套组件（21）和与其套接的磁棒（22），磁棒（22）连接用于驱动其相对磁套组件（21）上下移动的第二驱动机构（5）；第一驱动机构（4）和第二驱动机构（5）通过PLC协调运动；该装置具有自动化程度高，设备运行平稳，清洗效果好，清洗效率高的特点。

Description

清洗装置 技术领域
本发明涉及医疗设备技术领域，尤其是涉及一种清洗装置。
背景技术
发光免疫分析仪结合微磁珠固相载体平台与化学发光检测技术，不但具备了磁微粒化学发光检测的高灵敏度、结果准确以及自动化的特点，而且检测快速、使用操作简单且便于携带，因此特别适合门诊快速检测，家庭自我检测等POCT(point of care-testing)检测领域的应用。
微磁珠是进行试液分析的载体，需要对微磁珠进行清洗后才能通过测读模块采集最终的发光数据进行精确测读，所以，微磁珠的清洗是分析数据准确性的必要保证。
现有清洁微磁珠的方法自动化程度低，操作繁琐，效率低，清洁效果差，无法满足现代化检测的需求。
发明内容
本发明的目的是提供一种清洗装置，该装置自动化程度高，设备运行平稳，清洗效果好，清洗效率高。
本发明的上述发明目的是通过以下技术方案得以实现的：
一种清洗装置，包括倒U形架体，所述架体包括水平横梁，横梁两端分别连接与其垂直的竖梁，所述架体内设置有承载清洗机构的水平承载板以及可带动承载板上下移动的第一驱动机构，所述清洗机构包括磁套组件和与其套接的磁棒，所述磁棒的上端连接用于驱动其相对磁套组件上下移动的第二驱动机构；
所述磁套组件包括磁套座、磁套和磁棒，所述承载板上开设多个竖直通孔，所述通孔下端固定连通中空管状的磁套座，所述磁套座下端嵌套上开口的管状磁套，所述磁棒向下分别穿设通孔和磁套座并套设在磁套内；
所述第一驱动机构包括第一托板，所述第一托板位于承载板后侧并与其固定连接，所述第一托板下方设有水平支撑板，所述支撑板与两竖梁固定连接，所述横梁上端固定连接竖直设置的第一电机，所述第一电机的输出端穿设横梁连接竖直的第一丝杠，所述第一托板上固定连接与第一丝杠相适配的第一丝杠螺母，所述第一托板上还设有引导其上下移动的第一导向机构；
所述第二驱动机构包括设置在第一托板上方的第二托板，所述第一托板后侧固定连接竖直的 电机架，所述电机架上端固设竖直的第二电机，所述第二电机的输出端连接竖直的第二丝杠，所述第二托板上固定连接与第二丝杠相适配的第二丝杠螺母，所述第二托板上还设有引导其上下移动的第二导向机构，所述第二托板前侧固连用于卡接磁棒的卡板；
所述第一电机和第二电机与协调两者运动的PLC连接。
通过采用上述技术方案，第一电机通过第一丝杠可以带动第一托板、承载板、卡板以及第二托板一起做上下运动。当第一电机转动带动第一丝杠带动第一托板和第二托板一同向下运动时，首先将磁套座与试剂条中的磁套嵌套，然后，第二电机转动通过第二丝杠带动第二托板做上下运动，第二托板上固定连接的卡板则带动磁棒上下运动，使磁棒下端脱离开磁套底部或靠近磁套底部，通过磁棒抵靠磁套底部或脱离磁套底部，从而使试剂条上清洗孔内的微磁珠被磁棒吸引或脱离开磁棒的吸引达到清洗微磁珠的目的，第一电机和第二电机的工作状态是通过PLC控制协调的。
本发明进一步设置为：所述磁棒为杆状，其下部为磁性部，其上部设有向外突出的挡环，其顶端设有竖直的内螺纹孔。
通过采用上述技术方案，磁棒下部的磁性部可以对微磁珠进行吸引，设置挡环和内螺纹可以与卡板进行卡接并固定，使磁棒可以跟随着卡板做上下运动。
本发明进一步设置为：所述卡板设有开口面向第二托板的多个阶梯槽，所述阶梯槽下端的阶梯开设与磁棒适配的卡接孔，所述磁棒上端向上穿设卡接孔且挡环抵靠在卡板下端，所述内螺纹孔螺纹连接紧固件。
通过采用上述技术方案，可以使磁棒的挡环抵靠在卡板下端，紧固件将磁棒的上端固定在阶梯槽的阶梯上端，从而使磁棒与卡板紧固连接在一起，磁棒可以随卡板同步运动。
本发明进一步设置为：所述第一导向机构包括第一托板上位于第一丝杠两侧的第一滑移孔，每个所述第一滑移孔分别套设竖直的第一滑杆，每个所述第一滑杆两端并分别与横梁、支撑板固定连接；所述第二导向机构包括第二托板上位于第二丝杠两侧的第二滑移孔，每个所述第二滑移孔分别套设竖直的第二滑杆，每个所述第二滑杆两端并分别与横梁、支撑板固定连接。
通过采用上述技术方案，第一托板可以在其两侧的第一滑杆引导下进行上下运动，第二托板可以在其两侧的第二滑杆引导下进行上下运动，保证了第一托板、第二托板上下运行的平稳性。
本发明进一步设置为：所述第一滑移孔上固设同轴的第一滑套，所述第一滑套与第一滑杆滑动连接；所述第二滑移孔上固设同轴的第二滑套，所述第二滑套与第二滑杆滑动连接。
通过采用上述技术方案，第一滑杆在第一滑套内滑动，减小了摩擦力，提高了第一托板上下运行的平稳性；第二滑杆在第二滑套内滑动，同样减小了摩擦了，提高了第二托板上下运行的平稳性。
本发明进一步设置为：所述第一丝杠的另一端以及第二丝杠的另一端均为自由端。
通过采用上述技术方案，第一丝杠及第二丝杠的另一端均为自由端，可以减小设备体积，方便安装维护，提高设备的运行的可靠性。
本发明进一步设置为：所述第一托板上分别设有第二滑杆、第二丝杠的让位孔；所述第二托板上分别设有第一滑杆、第一丝杠的让位孔。
通过采用上述技术方案，设置让位孔可以保证第一滑杆、第二滑杆、第一丝杠及第二丝杠的顺利安装以及和第一托板及第二托板无干涉，保证第一托板及第二托板可以进行正常的上下运动。
本发明进一步设置为：所述承载板上的通孔、清洗机构和阶梯槽均设置8个。
通过采用上述技术方案，在承载板上设置8套清洗机构，第一电机带动第一托板和第二托板同步进行上下移动过程中，一次即可使8个清洗机构进行上下移动，可以同时进行8个试剂条内微磁珠的清洗工作，大大提高了清洗效率，提高了生产效率。
综上所述，本发明的有益技术效果为：
1、通过设置第一驱动机构和第二驱动机构，既可以实现清洗机构随第一托板和第二托板同步进行上下移动，还可以通过第二驱动机构使磁棒相对与磁套进行靠近或远离动作，从而使磁套外侧下端可以吸附微磁珠，又可以使磁套外侧下端的微磁珠脱离磁套，从而达到清洗微磁珠的目的，该装置自动化程度高，设备运行平稳，清洗效果好，清洗效率高。
2、通过设置第一导向机构和第二导向机构，使第一托板和第二托板上下运动的精度高，运行平稳。
3、通过在承载板上的通孔、清洗机构和阶梯槽均设置8个，可以同时进行8个试剂条内微磁珠的清洗工作，大大提高了清洗效率，提高了生产效率。
附图说明
图1是本发明的前视结构示意图；
图2是本发明去除卡板的结构示意图；
图3是本发明后视结构示意图；
图4是本发明卡板的结构示意图；
图5是本发明清洗机构的爆炸图；
图6是本发明试剂条架及试剂条的机构示意图。
图示，1、架体；11、横梁；12、竖梁；2、清洗机构；21、磁套组件；211、磁套座；212、磁套；22、磁棒；221、挡环；222、内螺纹孔；223、紧固件；3、承载板；31、通孔；4、第一驱动机构；41、第一托板；42、支撑板；43、第一电机；44、第一丝杠；45、第一丝杠螺母；46、第一导向机构；461、第一滑移孔；462、第一滑杆；463、第一滑套；5、第二驱动机构；51、第二托板；52、电机架；53、第二电机；54、第二丝杠；55、第二丝杠螺母；56、第二导向机构；561、第二滑移孔；562、第二滑杆；563、第二滑套；57、卡板；571、阶梯槽；572、卡接孔；6、让位孔；7、试剂条架；8、试剂条；81、反应孔；82、第一清洗孔；83、第二清洗孔；84、第三清洗孔；85、第四清洗孔；86、磁套放置孔。
具体实施方式
以下结合附图对本发明作进一步详细说明。
如图1-3所示，一种清洗装置，包括倒U形架体1，架体1包括水平横梁11，横梁11两端分别连接与其垂直的竖梁12，架体1内设置有承载清洗机构2的水平承载板3以及可带动承载板3上下移动的第一驱动机构4，清洗机构2包括磁套组件21和与其套接的磁棒22，磁棒22上端连接用于驱动其相对磁套组件21上下移动的第二驱动机构5。
磁套组件21包括磁套座211、磁套212和磁棒22，承载板3上开设多个竖直通孔31，通孔31下端固定连通中空管状的磁套座211，磁套座211下端嵌套上开口的管状磁套212，磁棒22向下分别穿设通孔31和磁套座211并套设在磁套212内。
第一驱动机构4包括第一托板41，第一托板41位于承载板3后侧并与其固定连接，第一托板41下方设有水平支撑板42，支撑板42与两竖梁12固定连接，横梁11上端固定连接竖直设置的第一电机43，第一电机43的输出端穿设横梁11连接竖直的第一丝杠44，第一托板41上固定连接与第一丝杠44相适配的第一丝杠螺母45，第一托板41上还设有引导其上下移动的第一导向机构46。
第二驱动机构5包括设置在第一托板41上方的第二托板51，第一托板41后侧固定连接竖直的电机架52，电机架52上端固设竖直的第二电机53，第二电机53的输出端连接竖直的第二丝杠54，第二托板51上固定连接与第二丝杠54相适配的第二丝杠螺母55，第二托板51上还设有引导其上下移动的第二导向机构56，第二托板51前侧固连用于卡接磁棒22的卡板57。
第一电机43和第二电机53的正反转以及运行的时间均通过PLC对两者进行协调控制。
本实施例中，为了提高第一托板41和第二托板51运动的精准性和平稳性，第一丝杠 44，第二丝杠54均采用T形螺杆。
第一电机43通过第一丝杠44可以带动第一托板41、承载板3、卡板57以及第二托板51一起做上下运动。当第一电机43转动，通过第一丝杠44带动第一托板41和第二托板51同步向下运动时，首先使磁套座211与试剂条8中的磁套212嵌套，然后，第二电机53转动，通过第二丝杠54带动第二托板51做上下运动，第二托板51上固定连接的卡板57则带动磁棒22上下运动，使磁棒22下端脱离开磁套212底部或靠近磁套212底部，通过磁棒22抵靠磁套212底部或脱离磁套212底部，从而使清洗孔内的微磁珠被磁棒22吸引或脱离开磁棒22的吸引达到清洗微磁珠的目的，第一电机43和第二电机53的工作状态是通过PLC控制协调的。
如图4所示，磁棒22为杆状，其下部为磁性部，磁棒22下部的磁性部可以对微磁珠进行吸引，磁棒22上部设有向外突出的挡环221，磁棒22顶端设有竖直的内螺纹孔222，设置挡环221和内螺纹可以与卡板57进行夹接并固定，使磁棒22可以跟随着卡板57做上下运动。
如图5所示，卡板57设有开口面向第二托板51的多个阶梯槽571，阶梯槽571下端的阶梯开设与磁棒22适配的卡接孔572，磁棒22上端向上穿设卡接孔572且挡环221抵靠在卡板57下端，内螺纹孔222螺纹连接紧固件223，紧固件223将磁棒22的上端固定在阶梯槽571的阶梯上端，从而使磁棒22与卡板57紧固连接在一起，磁棒22可以随卡板57同步上下运动。
本实施例的第一导向机构46包括第一托板41上位于第一丝杠44两侧的第一滑移孔461，每个第一滑移孔461分别套设竖直的第一滑杆462，每个第一滑杆462两端并分别与横梁11、支撑板42固定连接；第二导向机构56包括第二托板51上位于第二丝杠54两侧的第二滑移孔561，每个第二滑移孔561分别套设竖直的第二滑杆562，每个第二滑杆562两端并分别与横梁11、支撑板42固定连接；第一托板41可以在其两侧的第一滑杆462引导下进行上下运动，第二托板51可以在其两侧的第二滑杆562引导下进行上下运动，这保证了第一托板41、第二托板51上下运行的平稳性。
为了减小摩擦力，使托板与滑杆之间运行的更平稳、顺畅，第一滑移孔461上固设同轴的第一滑套463，第一滑套463与第一滑杆462滑动连接；第二滑移孔561上固设同轴的第二滑套563，第二滑套563与第二滑杆562滑动连接。
再一实施例中，第一丝杠44的另一端以及第二丝杠54的另一端均设置为自由端，可以减小设备体积，方便安装维护，提高设备的运行的可靠性。
为了保证第一滑杆462、第二滑杆562、第一丝杠44及第二丝杠54的顺利安装以及和第一托板41及第二托板51无干涉，在第一托板41上分别设有第二滑杆562、第二丝杠54的让位孔6，第二托板51上分别设有第一滑杆462、第一丝杠44的让位孔6。
本实施例中，承载板3上的通孔31、清洗机构2和阶梯槽571均设置8个，在承载板3上设置8套清洗机构2，第一电机43可以带动8套清洗机构2随第一托板41和第二托板51进行上下移动，以及第二电机53带动8个磁棒22相对应磁套212同时进行上下移动，一次即可使8个清洗机构2进行同时，可以同时进行8个试剂条8内微磁珠的清洗工作，大大提高了清洗效率，提高了生产效率。
图6为试剂条架7上放置了8个试剂条8的结构示意图。
参照图1、2、6所示，本发明工作过程如下：
首先将磁套212套设在磁套座211上。先将试剂条架7放置到架体1下方，使试剂条8上磁套212放置孔位于磁套座211的正下方，通过第二电机53将磁棒22升起，第二电机53停止工作，第一电机43正转，第一丝杠44带动第一托板41、承载板3、卡板57以及第二托板51同步向下运动，使磁套座211与试剂条8中磁套放置孔86中的磁套212嵌套。
再将第一电机43反转，通过第一丝杠44带动第一托板41、承载板3、卡板57以及第二托板51同步向上运动，移动试剂条架7，将试剂条8上的反应孔81放置到磁套212正下方，使第一电机43再次正转，第一丝杠44带动第一托板41、承载板3、卡板57以及第二托板51同步向下运动，使磁套212浸入反应孔81内的反应液中，第二电机53正转，第二丝杠54带动第一托板41、卡板57、磁棒22向下运动，使磁棒22与磁套212下端抵靠，由于磁棒22下部带有磁性，反应孔81内反应液中的微磁珠被磁棒22吸附到磁套212下端的外壁上。
第一电机43反转，第一丝杠44带动第一托板41、承载板3、卡板57以及第二托板51同步向上运动，移动试剂条架7，使试剂条8上的第一清洗孔82位于磁套212的正下方，第一电机43正转，第一丝杠44带动第一托板41、承载板3、卡板57以及第二托板51同步向下运动，使吸附有微磁珠的磁套212浸入第一清洗孔82后，第二电机53反转，第二丝杠54带动第一托板41、卡板57、磁棒22向上运动，使磁棒22远离磁套212下端，由于磁套212的阻挡，原来吸附到磁套212外侧下端的微磁珠没有了磁棒22的吸附力的作用，在重力的作用下有部分微磁珠会脱落到第一清洗孔82的清洗液中，此时，第一电机43正转和反转交替进行，带动磁套212在第一清洗孔82内的清洗液中进出，使磁套212在第一清洗孔82内的清洗液中一会浸入，一会脱离，经过数次上述混匀过程，原来吸附到磁套212上的微磁珠就 会全部散落到清洗液中，第二电机53再次正转，使磁棒22与磁套212下端抵靠，在磁力的作用下，微磁珠又被吸附到磁套212外侧下端，然后第二电机53又反转，使磁棒22向上运动并远离磁套212下端，再经过上述过程，使微磁珠又全部散落到第一清洗孔82内的清洗液中，连续重复数次上述清洗过程后，完成第一清洗孔82内微磁珠的清洗。
再使第二电机53正转，使磁棒22与磁套212下端抵靠，在磁力的作用下，微磁珠被吸附到磁套212外侧下端，然后第一电机43反转，使带有微磁珠的磁套212向上运动，移动试剂条架7，使试剂条8上的第二清洗孔83位于磁套212的正下方，第一电机43正转，使带有微磁珠的磁套212浸入到第二清洗孔83内，重复在第一清洗孔82内的清洗过程。
将带有微磁珠的磁套212浸入第三清洗孔84，继续重复第一清洗孔82内清洗的过程后，第一电机43反转，将带有微磁珠的磁套212升起，移动试剂条架7，使试剂条8上的第四清洗孔85位于磁套212的正下方，将带有微磁珠的磁套212再浸入到第四清洗孔85的清洗液中，第二电机53反转，磁棒22远离磁套212下端，经过三次清洗后的微磁珠在失去磁棒22的磁力吸引后，在重力的作用下散落到第四清孔的清洗液中，第一电机43反转，第一丝杠44带动第一托板41、承载板3、卡板57以及第二托板51同步向上运动，微磁珠的清洗工作完毕，移动试剂条架7上的试剂条8进行下一工序的测试工作。
本具体实施方式的实施例均为本发明的较佳实施例，并非依此限制本发明的保护范围，故：凡依本发明的结构、形状、原理所做的等效变化，均应涵盖于本发明的保护范围之内。

Claims (8)

  1. 一种清洗装置，其特征在于,包括倒U形架体(1)，所述架体(1)包括水平横梁(11)，横梁(11)两端分别连接与其垂直的竖梁(12)，所述架体(1)内设置有承载清洗机构(2)的水平承载板(3)以及可带动承载板(3)上下移动的第一驱动机构(4)，所述清洗机构(2)包括磁套组件(21)和与其套接的磁棒(22)，所述磁棒(22)上端连接用于驱动其相对磁套组件(21)上下移动的第二驱动机构(5)；
    所述磁套组件(21)包括磁套座(211)、磁套(212)和磁棒(22)，所述承载板(3)上开设多个竖直通孔(31)，所述通孔(31)下端固定连通中空管状的磁套座(211)，所述磁套座(211)下端嵌套上开口的管状磁套(212)，所述磁棒(22)向下分别穿设通孔(31)和磁套座(211)并套设在磁套(212)内；
    所述第一驱动机构(4)包括第一托板(41)，所述第一托板(41)位于承载板(3)后侧并与其固定连接，所述第一托板(41)下方设有水平支撑板(42)，所述支撑板(42)与两竖梁(12)固定连接，所述横梁(11)上端固定连接竖直设置的第一电机(43)，所述第一电机(43)的输出端穿设横梁(11)连接竖直的第一丝杠(44)，所述第一托板(41)上固定连接与第一丝杠(44)相适配的第一丝杠螺母(45)，所述第一托板(41)上还设有引导其上下移动的第一导向机构(46)；
    所述第二驱动机构(5)包括设置在第一托板(41)上方的第二托板(51)，所述第一托板(41)后侧固定连接竖直的电机架(52)，所述电机架(52)上端固设竖直的第二电机(53)，所述第二电机(53)的输出端连接竖直的第二丝杠(54)，所述第二托板(51)上固定连接与第二丝杠(54)相适配的第二丝杠螺母(55)，所述第二托板(51)上还设有引导其上下移动的第二导向机构(56)，所述第二托板(51)前侧固连用于卡接磁棒(22)的卡板(57)；
    所述第一电机(43)和第二电机(53)与协调两者运动的PLC连接。
  2. 如权利要求1所述的清洗装置，其特征在于，所述磁棒(22)为杆状，其下部为磁性部，其上部设有向外突出的挡环(221)，其顶端设有竖直的内螺纹孔(222)。
  3. 如权利要求2所述的清洗装置，其特征在于，所述卡板(57)设有开口面向第二托板(51)的多个阶梯槽(571)，所述阶梯槽(571)下端的阶梯开设与磁棒(22)适配的卡接孔(572)，所述磁棒(22)上端向上穿设卡接孔(572)且挡环(221)抵靠在卡板(57)下端，所述内螺纹孔(222)螺纹连接紧固件(223)。
  4. 如权利要求1所述的清洗装置，其特征在于，所述第一导向机构(46)包括第一托板(41)上位于第一丝杠(44)两侧的第一滑移孔(461)，每个所述第一滑移孔(461)分别套设竖直的第一滑杆(462)，每个所述第一滑杆(462)两端并分别与横梁(11)、支撑板(42)固定连接；所述第二导向机构(56)包括第二托板(51)上位于第二丝杠(54)两侧的第二滑移孔(561)，每个所述第二滑 移孔(561)分别套设竖直的第二滑杆(562)，每个所述第二滑杆(562)两端并分别与横梁(11)、支撑板(42)固定连接。
  5. 如权利要求4所述的清洗装置，其特征在于，所述第一滑移孔(461)上固设同轴的第一滑套(463)，所述第一滑套(463)与第一滑杆(462)滑动连接；所述第二滑移孔(561)上固设同轴的第二滑套(563)，所述第二滑套(563)与第二滑杆(562)滑动连接。
  6. 如权利要求1所述的清洗装置，其特征在于，所述第一丝杠(44)的另一端以及第二丝杠(54)的另一端均为自由端。
  7. 如权利要求4所述的清洗装置，其特征在于，所述第一托板(41)上分别设有第二滑杆(562)、第二丝杠(54)的让位孔(6)；所述第二托板(51)上分别设有第一滑杆(462)、第一丝杠(44)的让位孔(6)。
  8. 如权利要求3所述的清洗装置，其特征在于，所述承载板(3)上的通孔(31)、清洗机构(2)和阶梯槽(571)均设置8个。
PCT/CN2020/104910 2020-03-30 2020-07-27 清洗装置 WO2021196464A1 (zh)

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CN115228527B (zh) * 2022-08-12 2023-07-21 北京美联泰科生物技术有限公司 一种支持移液以及清洗同位操作的装置
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