WO2021182572A1 - 癌の治療及び／又は予防のための医薬品 - Google Patents

癌の治療及び／又は予防のための医薬品 Download PDF

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Publication number
WO2021182572A1
WO2021182572A1 PCT/JP2021/009797 JP2021009797W WO2021182572A1 WO 2021182572 A1 WO2021182572 A1 WO 2021182572A1 JP 2021009797 W JP2021009797 W JP 2021009797W WO 2021182572 A1 WO2021182572 A1 WO 2021182572A1
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WO
WIPO (PCT)
Prior art keywords
seq
chain variable
amino acid
acid sequence
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/009797
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English (en)
French (fr)
Japanese (ja)
Inventor
文義 岡野
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to US17/910,544 priority Critical patent/US20230140155A1/en
Priority to EP21768433.1A priority patent/EP4119159A4/en
Priority to CA3175129A priority patent/CA3175129A1/en
Priority to JP2021531943A priority patent/JP7793985B2/ja
Priority to KR1020227035177A priority patent/KR20220153615A/ko
Priority to BR112022018171A priority patent/BR112022018171A2/pt
Publication of WO2021182572A1 publication Critical patent/WO2021182572A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Definitions

  • An antibody or fragment thereof comprising the amino acid sequence of SEQ ID NO: 59
  • An antibody in which the fragment (e) heavy chain variable region contains the amino acid sequence of SEQ ID NO: 68 and the light chain variable region contains the amino acid sequence of SEQ ID NO: 69, or a fragment (f) heavy chain variable region thereof is SEQ ID NO:
  • An antibody or fragment thereof (g) containing 70 amino acid sequences and the light chain variable region containing the amino acid sequence of SEQ ID NO: 71.
  • the heavy chain variable region contains the amino acid sequence of SEQ ID NO: 72 and the light chain variable.
  • kit preparation is, for example, a kit preparation containing a preparation (or pharmaceutical composition) containing an anti-CAPRIN-1 antibody and a preparation (or pharmaceutical composition) containing a pyrimidine drug and carboplatin.
  • a kit preparation containing a preparation (or pharmaceutical composition) containing an anti-CAPRIN-1 antibody and a preparation (or pharmaceutical composition) containing a pyrimidine drug and carboplatin.
  • the kit preparation according to the present invention may contain other preparations (other known antitumor agents or other pyrimidine-based agents) in addition to the anti-CAPLIN-1 antibody, pyrimidine-based agent and carboplatin.
  • the anti-CAPRIN-1 antibody used in the present invention may be a monoclonal antibody or a polyclonal antibody.
  • Antibodies used in the present invention include human antibodies, humanized antibodies, chimeric antibodies, and non-human animal antibodies.
  • an antibody or fragment thereof in which the heavy chain variable region contains the amino acid sequence of SEQ ID NO: 39 and the light chain variable region contains the amino acid sequence of SEQ ID NO: 43, or the heavy chain variable region is SEQ ID NO: 70.
  • An antibody or fragment thereof that contains a light chain variable region containing, and is immunologically reactive with the CAPRIN-1 protein, or complementarity determining regions of SEQ ID NOs: 176, 177, and 178 (CDR1, CDR2, and CDR3, respectively).
  • CDR1, CDR2, and CDR3, respectively complementarity determining regions of SEQ ID NOs: 176, 177, and 178
  • light chain variable regions containing the complementarity determining regions of SEQ ID NOs: 179, 180 and 181 CDR1, CDR2 and CDR3, respectively
  • these cancers may be primary cancers, metastatic cancers, metastatic or recurrent cancers, postoperative cancers, or unresectable cancers.
  • melanoma is often used synonymously with malignant melanoma or malignant melanoma.
  • the active ingredients of the pharmaceutical products for the treatment and / or prevention of the cancer of the present invention are co-administered
  • the active ingredients of the present invention anti-CAPRIN-1 antibody of the present invention, pyrimidine drug and carboplatin
  • the pharmaceutical composition containing the drug is administered as one cycle for about 2 days to about 3 weeks. After that, it can be repeated as needed according to the judgment of the doctor in charge of the treatment cycle.
  • the duration of administration of each individual drug should be adjusted to span the same duration. The interval between cycles can be varied from 0 to 2 months.
  • the dose of each active ingredient of the pharmaceutical product for treating and / or preventing the cancer of the present invention can be set in the same manner as the dose of each active ingredient in the above-mentioned pharmaceutical composition.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/JP2021/009797 2020-03-12 2021-03-11 癌の治療及び／又は予防のための医薬品 Ceased WO2021182572A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US17/910,544 US20230140155A1 (en) 2020-03-12 2021-03-11 Medicament for treatment and/or prevention of cancer
EP21768433.1A EP4119159A4 (en) 2020-03-12 2021-03-11 MEDICINE FOR THE TREATMENT AND/OR PREVENTION OF CANCER
CA3175129A CA3175129A1 (en) 2020-03-12 2021-03-11 Medicament for treatment and/or prevention of cancer
JP2021531943A JP7793985B2 (ja) 2020-03-12 2021-03-11 癌の治療及び／又は予防のための医薬品
KR1020227035177A KR20220153615A (ko) 2020-03-12 2021-03-11 암의 치료 및/또는 예방을 위한 의약품
BR112022018171A BR112022018171A2 (pt) 2020-03-12 2021-03-11 Medicamento para o tratamento e/ou a prevenção de câncer, agentes aumentando a eficácia de droga de uma composição farmacêutica e método para tratar e/ou prevenir câncer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020-043020 2020-03-12
JP2020043020 2020-03-12

Publications (1)

Publication Number Publication Date
WO2021182572A1 true WO2021182572A1 (ja) 2021-09-16

Family

ID=77670688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2021/009797 Ceased WO2021182572A1 (ja) 2020-03-12 2021-03-11 癌の治療及び／又は予防のための医薬品

Country Status (7)

Country Link
US (1) US20230140155A1 (https=)
EP (1) EP4119159A4 (https=)
JP (1) JP7793985B2 (https=)
KR (1) KR20220153615A (https=)
BR (1) BR112022018171A2 (https=)
CA (1) CA3175129A1 (https=)
WO (1) WO2021182572A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101638490B1 (ko) * 2008-08-05 2016-07-11 도레이 카부시키가이샤 암의 치료 및 예방용 의약 조성물

Citations (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0239400A2 (en) 1986-03-27 1987-09-30 Medical Research Council Recombinant antibodies and methods for their production
WO1996002576A1 (en) 1994-07-13 1996-02-01 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin-8
WO1999051743A1 (en) 1998-04-03 1999-10-14 Chugai Seiyaku Kabushiki Kaisha Humanized antibody against human tissue factor (tf) and process for constructing humanized antibody
US6602684B1 (en) 1998-04-20 2003-08-05 Glycart Biotechnology Ag Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
WO2004063351A2 (en) 2003-01-09 2004-07-29 Macrogenics, Inc. IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
WO2005063351A1 (de) 2003-12-19 2005-07-14 Bayer Technology Services Gmbh Strangverdampfervorrichtung
EP1914244A2 (en) 1999-04-09 2008-04-23 Kyowa Hakko Kogyo Co., Ltd. Method of modulating the activity of functional immune molecules
US7579170B2 (en) 2000-04-12 2009-08-25 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Method for preparing monoclonal antibodies capable of activating effector cells expressing FCγRIII
WO2010016526A1 (ja) 2008-08-05 2010-02-11 東レ株式会社 癌の治療及び予防用医薬組成物
WO2011005481A1 (en) 2009-06-22 2011-01-13 Medimmune, Llc ENGINEERED Fc REGIONS FOR SITE-SPECIFIC CONJUGATION
WO2011096534A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2011096519A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2011096533A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2011096517A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2011096535A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防のための医薬品
WO2011096528A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2011120135A1 (en) 2010-03-29 2011-10-06 Zymeworks, Inc. Antibodies with enhanced or suppressed effector function
WO2013018889A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013018894A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013018886A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 膵臓癌の治療及び／又は予防用医薬組成物
WO2013018891A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013018883A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013018892A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び／又は予防用医薬組成物
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
WO2013125654A1 (ja) 2012-02-21 2013-08-29 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013125636A1 (ja) 2012-02-21 2013-08-29 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013125640A1 (ja) 2012-02-21 2013-08-29 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013125630A1 (ja) 2012-02-21 2013-08-29 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013147176A1 (ja) 2012-03-30 2013-10-03 東レ株式会社 胆嚢癌の治療及び／又は予防用医薬組成物
WO2013147169A1 (ja) 2012-03-30 2013-10-03 東レ株式会社 肝臓癌の治療及び／又は予防用医薬組成物
WO2014012479A1 (en) 2012-07-18 2014-01-23 Shanghai Birdie Biotech, Inc. Compounds for targeted immunotherapy
US8642292B2 (en) 2009-09-22 2014-02-04 Probiogen Ag Process for producing molecules containing specialized glycan structures
WO2015020212A1 (ja) 2013-08-09 2015-02-12 東レ株式会社 癌の治療及び／又は予防用医薬組成物
JP2017535548A (ja) * 2014-11-14 2017-11-30 ジェネンテック， インコーポレイテッド Ｖｅｇｆアンタゴニストの応答の予測
WO2019189780A1 (ja) * 2018-03-30 2019-10-03 東レ株式会社 癌の治療及び／又は予防用医薬組成物
JP2020043020A (ja) 2018-09-12 2020-03-19 日産自動車株式会社 燃料電池システム

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240005247A (ko) * 2016-10-28 2024-01-11 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물

Patent Citations (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0239400A2 (en) 1986-03-27 1987-09-30 Medical Research Council Recombinant antibodies and methods for their production
WO1996002576A1 (en) 1994-07-13 1996-02-01 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin-8
WO1999051743A1 (en) 1998-04-03 1999-10-14 Chugai Seiyaku Kabushiki Kaisha Humanized antibody against human tissue factor (tf) and process for constructing humanized antibody
US6602684B1 (en) 1998-04-20 2003-08-05 Glycart Biotechnology Ag Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP1914244A2 (en) 1999-04-09 2008-04-23 Kyowa Hakko Kogyo Co., Ltd. Method of modulating the activity of functional immune molecules
US7579170B2 (en) 2000-04-12 2009-08-25 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Method for preparing monoclonal antibodies capable of activating effector cells expressing FCγRIII
WO2004063351A2 (en) 2003-01-09 2004-07-29 Macrogenics, Inc. IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
WO2005063351A1 (de) 2003-12-19 2005-07-14 Bayer Technology Services Gmbh Strangverdampfervorrichtung
WO2010016526A1 (ja) 2008-08-05 2010-02-11 東レ株式会社 癌の治療及び予防用医薬組成物
WO2011005481A1 (en) 2009-06-22 2011-01-13 Medimmune, Llc ENGINEERED Fc REGIONS FOR SITE-SPECIFIC CONJUGATION
US8642292B2 (en) 2009-09-22 2014-02-04 Probiogen Ag Process for producing molecules containing specialized glycan structures
WO2011096519A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2011096533A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2011096517A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2011096535A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防のための医薬品
WO2011096528A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2011096534A1 (ja) 2010-02-04 2011-08-11 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2011120135A1 (en) 2010-03-29 2011-10-06 Zymeworks, Inc. Antibodies with enhanced or suppressed effector function
WO2013018889A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013018894A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013018883A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013018892A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013018886A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 膵臓癌の治療及び／又は予防用医薬組成物
WO2013018891A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013125654A1 (ja) 2012-02-21 2013-08-29 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013125636A1 (ja) 2012-02-21 2013-08-29 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013125640A1 (ja) 2012-02-21 2013-08-29 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013125630A1 (ja) 2012-02-21 2013-08-29 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2013147176A1 (ja) 2012-03-30 2013-10-03 東レ株式会社 胆嚢癌の治療及び／又は予防用医薬組成物
WO2013147169A1 (ja) 2012-03-30 2013-10-03 東レ株式会社 肝臓癌の治療及び／又は予防用医薬組成物
WO2014012479A1 (en) 2012-07-18 2014-01-23 Shanghai Birdie Biotech, Inc. Compounds for targeted immunotherapy
WO2015020212A1 (ja) 2013-08-09 2015-02-12 東レ株式会社 癌の治療及び／又は予防用医薬組成物
JP2017535548A (ja) * 2014-11-14 2017-11-30 ジェネンテック， インコーポレイテッド Ｖｅｇｆアンタゴニストの応答の予測
WO2019189780A1 (ja) * 2018-03-30 2019-10-03 東レ株式会社 癌の治療及び／又は予防用医薬組成物
JP2020043020A (ja) 2018-09-12 2020-03-19 日産自動車株式会社 燃料電池システム

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
ANONYMOUS: "A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors Condition or disease  Intervention/treatment Phase Go to", CLINIALTRIALS.GOV, 13 March 2019 (2019-03-13), XP055856868, Retrieved from the Internet <URL:https://www.clinicaltrials.gov/ct2/show/NCT03872947> [retrieved on 20211102] *
CARL, A.K. BORREBAECKJAMES, W. LARRICK: "THERAPEUTIC MONOCLONAL ANTIBODIES", 1990, MACMILLAN PUBLISHERS LTD
J CLIN ONCOL, vol. 30, 2012, pages 1879 - 1887
KARLINALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
KOHLER, G.MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
SATO K. ET AL., CANCER RESEARCH, vol. 53, 1993, pages 851 - 856
See also references of EP4119159A4

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