WO2021131750A1 - 目元のくま改善用の外用組成物、化粧品及び医薬部外品 - Google Patents

目元のくま改善用の外用組成物、化粧品及び医薬部外品 Download PDF

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Publication number
WO2021131750A1
WO2021131750A1 PCT/JP2020/046083 JP2020046083W WO2021131750A1 WO 2021131750 A1 WO2021131750 A1 WO 2021131750A1 JP 2020046083 W JP2020046083 W JP 2020046083W WO 2021131750 A1 WO2021131750 A1 WO 2021131750A1
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Prior art keywords
external composition
seed oil
oil
phylloquinone
eyes
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PCT/JP2020/046083
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English (en)
French (fr)
Japanese (ja)
Inventor
三井　幸雄
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株式会社ホルス
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Priority to KR1020227015177A priority Critical patent/KR20220122600A/ko
Priority to CN202080079397.1A priority patent/CN114727944A/zh
Publication of WO2021131750A1 publication Critical patent/WO2021131750A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • the present invention relates to an external composition for improving dark circles around the eyes, cosmetics, and quasi-drugs.
  • Phylloquinone (vitamin K 1) is known as a component for dissolving blood clots under the eye by topical application, it is possible to improve the dark circles around the eyes.
  • ⁇ -tocopherol has an antioxidant effect and enhances the thrombolytic function of phylloquinone.
  • one or more of vitamin A, vitamin C, and vitamin E having an antioxidant effect are blended with vitamin K, and if necessary, soybean lecithin, green tea extract, soybean lecithin, and jojoba are blended. A cosmetic that improves dullness, dark circles, etc.
  • Patent Document 2 describes vitamin K 1 , vitamin K 2 , vitamin K 3 , vitamin K 4 , vitamin K 5 , vitamin K 6 , vitamin K 7 and its homologues, steric isomers, and vitamin K group of salts.
  • a whitening cosmetic containing one or a mixture of two or more of them is disclosed.
  • an object of the present invention is to provide an external composition for improving dark circles under the eyes, which contains a predetermined amount or more of natural phylloquinone derived from vegetable oils and fats and ⁇ -tocopherol.
  • the external composition for improving dark circles around the eyes according to claim 1 contains chaseed oil and vegetable oil other than chaseed oil, and contains 100 ⁇ g / 100 g or more of chaseed oil and phyroquinone derived from the vegetable oil, and chaseed. It is characterized by containing 20 mg / 100 g or more of ⁇ -tocopherol derived from oil and vegetable oil.
  • an external composition for improving dark circles around the eyes which contains a predetermined amount or more of natural phylloquinone derived from vegetable oils and fats and ⁇ -tocopherol, and can be blended in cosmetics and quasi-drugs. Can be done. Further, by combining tea seed oil with other vegetable oils, the amount of rare tea seed oil used can be suppressed.
  • the present invention according to claim 2 contains 60 to 40 mg / 100 g of chaseed oil containing 300 to 1000 ⁇ g / 100 g of phylloquinone and 10 to 40 mg / 100 g of ⁇ -tocopherol in the external composition for improving dark circles around the eyes according to claim 1. It is characterized in that it is blended in an amount of 80% by mass. According to the second aspect of the present invention, the amount of phylloquinone and ⁇ -tocopherol contained in the external composition can be increased, and the effect of improving dark circles around the eyes can be further enhanced.
  • the external composition for improving the dark circles around the eyes according to the second aspect, 2% by mass or more of grape seed oil containing 400 to 600 ⁇ g / 100 g of phylloquinone is blended as a vegetable oil. It is characterized by that. According to the third aspect of the present invention, it is possible to secure the amount of natural phylloquinone while suppressing the amount of tea seed oil used. Further, by blending grape seed oil containing vitamin E, the thrombolytic action of phylloquinone can be enhanced.
  • the present invention according to claim 4 is characterized in that, in the external composition for improving dark circles around the eyes according to claim 3, the blending amount of grape seed oil is 8% by mass or less. According to the fourth aspect of the present invention, the quality of the external composition can be stabilized by setting the blending amount of the grape seed oil to a predetermined value or less.
  • the present invention according to claim 5 is the external composition for improving dark circles around the eyes according to any one of claims 1 to 4, wherein apricot kernel oil is blended as a vegetable oil and ⁇ -tocopherol is 30 mg / 100 g. It is characterized by containing the above. According to the fifth aspect of the present invention, the effect of improving dark circles around the eyes can be further enhanced.
  • the cosmetic product according to claim 6 is characterized in that the external composition for improving dark circles around the eyes according to any one of claims 1 to 5 is blended. According to the sixth aspect of the present invention, it is possible to provide cosmetics containing natural phylloquinone derived from vegetable oils and fats.
  • the quasi-drug corresponding to claim 7 is characterized in that the external composition for improving dark circles around the eyes according to any one of claims 1 to 5 is blended. According to the seventh aspect of the present invention, it is possible to provide a quasi-drug containing natural phylloquinone derived from vegetable oils and fats.
  • an external composition for improving dark circles around the eyes of the present invention that contains a predetermined amount or more of natural phylloquinone derived from vegetable oils and fats and ⁇ -tocopherol and can be blended in cosmetics and quasi-drugs. Can be provided. Further, by combining tea seed oil with other vegetable oils, the amount of rare tea seed oil used can be suppressed.
  • Table comparing 100% tea seed oil with Example 1 and Comparative Example 1 for fatty acids The figure which shows the result of the effect comparison test 1 on the facial skin of the external composition by a human monitor.
  • Table 1 below is a table showing the detected values of the components for each of 100% tea seed oil and 100% grape seed oil. If it is not detected, it is set to "-".
  • tea seed oil contains 300 to 1000 ⁇ g / 100 g of phylloquinone and 10 to 40 mg / 100 g of ⁇ -tocopherol.
  • Phytonadione (vitamin K 1 ) is a component that dissolves blood clots under the eyes when applied externally
  • ⁇ -tocopherol is a component that has an antioxidant effect and enhances the thrombus-dissolving function of phylloquinone.
  • an external composition containing chaseed oil and other vegetable oils containing 100 ⁇ g / 100 g or more of chaseed oil and phyroquinone derived from vegetable oil, and 30 mg / 100 g or more of ⁇ -tocopherol derived from chaseed oil and vegetable oil. To do.
  • tea seed oil By combining tea seed oil with other vegetable oils in this way, the amount of rare tea seed oil used can be suppressed. Further, when the external composition contains natural phylloquinone derived from vegetable oil and fat and ⁇ -tocopherol in a predetermined amount or more, the dark circles around the eyes can be effectively improved. Mixing of tea seed oil and other vegetable oils is carried out, for example, by putting each oil in a container, stirring at room temperature and normal pressure, and filtering impurities.
  • the external composition preferably contains 60 to 80% by mass of tea seed oil containing 300 to 1000 ⁇ g / 100 g of phylloquinone and 10 to 40 mg / 100 g of ⁇ -tocopherol.
  • the amount of phylloquinone and ⁇ -tocopherol in the external composition can be increased, and the effect of improving the dark circles around the eyes can be further enhanced.
  • Japanese tea berries contain more phylloquinone than overseas tea berries, it is preferable to use Japanese tea berries as the tea berries used for tea seed oil.
  • grape seed oil contains 400 to 600 ⁇ g / 100 g of phylloquinone. Therefore, as a vegetable oil to be combined with tea seed oil, it is preferable to use 2% by mass or more of grape seed oil containing 400 to 600 ⁇ g / 100 g of phylloquinone. As a result, the amount of natural phylloquinone can be secured while suppressing the amount of tea seed oil used.
  • cha seed oil contains vitamin A such as retinol (active equivalent), ⁇ -carotene, and ⁇ -carotene, but grape seed oil does not contain vitamin A.
  • grape seed oil contains vitamin E such as ⁇ -tocopherol, ⁇ -tocopherol, and ⁇ -tocopherol, which are not contained in tea seed oil. Therefore, by blending grape seed oil containing plant-derived vitamin E, the thrombolytic action of phylloquinone can be enhanced.
  • the blending amount of grape seed oil is preferably 8% by mass or less, and more preferably 4% by mass or less.
  • the quality of the external composition can be stabilized.
  • the external composition contains apricot kernel oil as a vegetable oil.
  • Table 2 is a table showing the detected values of the components of avocado oil, apricot kernel oil (apricot kernel oil), and canina rose fruit oil.
  • apricot kernel oil contains a large amount of ⁇ -tocopherol. Therefore, by adding apricot kernel oil, the amount of tea seed oil used can be reduced and the content of ⁇ -tocopherol can be increased to increase the content of ⁇ -tocopherol. The effect of improving bears can be further enhanced.
  • avocado oil, apricot kernel oil, and canina rose fruit oil contain vitamin E such as ⁇ -tocopherol, ⁇ -tocopherol, and ⁇ -tocopherol, which are not contained in tea seed oil. Therefore, by blending avocado oil, apricot kernel oil, or canina rose fruit oil containing plant-derived vitamin E, the thrombolytic action of phylloquinone can be enhanced.
  • the external composition contains 60 to 85 g / 100 g of unsaturated fatty acid, and 60 to 80% of the unsaturated fatty acid is oleic acid.
  • cosmetics or quasi-drugs containing natural phylloquinone derived from vegetable oils and fats.
  • FIG. 1 is a table showing the amount of each component of the external composition for improving dark circles around the eyes according to the embodiment of the present invention and the amount of each component of the external composition which is a comparative example.
  • the component values of Example 1 and Comparative Example 1 are detected values, and the component values of Examples 2 to 6 are calculated values. If it is not detected, it is set to "-".
  • the external composition of Example 1 contains 60% by mass of cha seed oil (cha seed oil), 12% by mass of avocado oil, 12% by mass of canina rose fruit oil (rosehip oil), and apricot kernel oil (persic oil). It consists of 12% by mass and 4% by mass of grape seed oil.
  • the external composition of Example 2 was 40% by mass of cha seed oil, 18.67% by mass of avocado oil, 18.67% by mass of canina rose fruit oil, 18.67% by mass of apricot kernel oil, and grape seed oil. It consists of 4% by mass.
  • the external composition of Example 3 was 80% by mass of cha seed oil, 5.33% by mass of avocado oil, 5.33% by mass of canina rose fruit oil, 5.33% by mass of apricot kernel oil, and grape seed oil. It consists of 4% by mass.
  • the external composition of Example 4 comprises 60% by mass of tea seed oil, 36% by mass of soybean oil, and 4% by mass of grape seed oil.
  • the external composition of Example 5 comprises 60% by mass of tea seed oil, 36% by mass of olive oil, and 4% by mass of grape seed oil.
  • the external composition of Example 6 comprises 60% by mass of tea seed oil, 18% by mass of soybean oil, 18% by mass of olive oil, and 4% by mass of grape seed oil.
  • the external composition of Comparative Example 1 did not contain cha seed oil and grape seed oil, and contained 33% by mass of avocado oil, 33% by mass of canina rose fruit oil, 33% by mass of apricot kernel oil, and sunflower seed oil. It consists of 1% by mass.
  • the content of phylloquinone was 368 ⁇ g / 100 g in Example 1, 269 ⁇ g / 100 g in Example 2, 467 ⁇ g / 100 g in Example 3, 373 ⁇ g / 100 g in Example 4, 361 ⁇ g / 100 g in Example 5, and in Example 6. It is 369 ⁇ g / 100 g, and both are 100 ⁇ g / 100 g or more.
  • the content of phylloquinone in Comparative Example 1 is 30 ⁇ g / 100 g, which is less than 100 ⁇ g / 100 g.
  • the amount of ⁇ -tocopherol was 35.7 mg / 100 g in Example 1, 40 mg / 100 g in Example 2, 32 mg / 100 g in Example 3, 22 mg / 100 g in Example 4, and 27 mg / 100 g in Example 5. In Example 6, it is 21 mg / 100 g, and both are 20 mg / 100 g or more. Further, although Vitamin A is contained in Examples 1 to 6, Vitamin A is not contained in Comparative Example 1.
  • FIG. 2 is a table comparing Example 1 (cha seed oil 60%) and Comparative Example 1 (cha seed oil 0%) with respect to fatty acids. If it is not detected, it is set to "-". As shown in FIG. 2, the external composition of Example 1 contains 79.4 g / 100 g of unsaturated fatty acids, and about 70.8% of the unsaturated fatty acids is oleic acid. On the other hand, Comparative Example 1 contains 80.5 g / 100 g of unsaturated fatty acids, and oleic acid in the unsaturated fatty acids is only about 52.7%.
  • FIG. 3 is a diagram showing the results of the effect comparison test 1 of the external composition on the facial skin by a human monitor
  • FIG. 3 (a) shows the results for skin stains
  • FIG. 3 (b) is under the eyes. Shows the results for wrinkles.
  • 5 subjects were given a cream containing the external composition of Example 1 twice a day, only on the half face, and after washing the face, about 2 grains of rice were applied under the eyes. I was asked to.
  • ⁇ is the average value of the results of the half face on the side to which the cream containing the external composition of Example 1 was applied
  • ⁇ is the average value of the results of the half face on the non-applied side.
  • FIG. 3A the number of stains increased on the half face on the non-applied side, whereas it was significant (p ⁇ 0.05) on the half face on the cream-applied side. There was a significant decrease.
  • FIG. 3B the number of wrinkles under the eyes increased on the half face on the non-applied side, while decreased on the half face on the cream-applied side. Since one subject could not be analyzed, the average value of four subjects is used.
  • FIG. 4 is a diagram showing the results of the effect comparison test 2 on the facial skin of the external composition by a human monitor
  • FIG. 4 (a) shows the results for skin stains
  • FIG. 4 (b) is under the eyes. Shows the results for wrinkles.
  • 12 subjects were divided into 3 groups, and in addition to normal care, a cream containing the external composition of Example 1, a cream containing the external composition of Example 2, or Example 3 After washing the face twice a day, the cream containing the external composition of No. 2 was applied under the eyes of about 2 grains of rice.
  • Example 2 (containing 40% tea seed oil) is slightly more effective than Example 1 (containing 60% tea seed oil) and Example 3 (containing 80% tea seed oil). small. Therefore, it is preferable that the tea seed oil is blended in an amount of 60 to 80% by mass.
  • Example 1 the external composition of Example 1 in which the amount of rare tea seed oil used is smaller is used for the dark circles around the eyes. Since it can be judged that the best balance is obtained in terms of improvement effect, stable supply, and cost, it is most preferable that the tea seed oil is blended in an amount of 60% by mass.
  • Tea seed oil used in the present invention is rare.
  • the production amount of tea seed itself which is the raw material of tea seed oil, is small due to the following backgrounds (1) to (3).
  • Tea is usually not cultivated to bloom and bear fruit in order to nourish the tea leaves.
  • Tea trees do not bloom easily unless stress is applied, and because of self-incompatibility, they do not bear fruit in the same tree, so unless care is taken, they will not bear fruit. Another reason is that it takes time to extract from the fruit.
  • FIG. 5 is a diagram showing the results of the effect comparison test 3 of the external composition on the facial skin by a human monitor
  • FIG. 5 (a) shows the results for skin stains
  • FIG. 5 (b) is below the eye. Shows the results for wrinkles.
  • 16 subjects were divided into 4 groups, and in addition to normal care, a cream containing the external composition of Example 1, a cream containing the external composition of Example 4, and Example 5
  • the cream containing the external composition or the cream containing the external composition of Example 6 was applied twice a day after washing the face, and then about 2 grains of rice were applied under the eyes.
  • ⁇ is the average value of the result of applying the cream containing the external composition of Example 5
  • x is the average value of the result of applying the cream containing the external composition of Example 6. Is expressed as a relative value when is 100%.
  • FIG. 5A the number of stains is reduced in all the examples.
  • FIG. 5B the number of wrinkles under the eyes is reduced in all the examples. Therefore, it can be seen that any of the external composition of Examples 4 to 6 is effective for dark circles around the eyes.
  • Example 1 containing 30 mg / 100 g or more of ⁇ -tocopherol in Examples 4 to 6 It shows better results than ( ⁇ tocopherol is less than 30 mg / 100 g). Therefore, the external composition preferably contains 30 mg / 100 g or more of ⁇ -tocopherol.

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PCT/JP2020/046083 2019-12-27 2020-12-10 目元のくま改善用の外用組成物、化粧品及び医薬部外品 WO2021131750A1 (ja)

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KR1020227015177A KR20220122600A (ko) 2019-12-27 2020-12-10 눈가의 다크서클 개선용의 외용 조성물, 화장품 및 의약부 외품
CN202080079397.1A CN114727944A (zh) 2019-12-27 2020-12-10 用于改善眼周的黑眼圈的外用组合物、化妆品以及医药外用品

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JP2019-238748 2019-12-27
JP2019238748A JP7333606B2 (ja) 2019-12-27 2019-12-27 目元のくま改善用の外用組成物、化粧品及び医薬部外品

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JP2004196759A (ja) * 2002-12-18 2004-07-15 Takashi Suzuki ビタミンｋ類とビタミンｅ複合の美肌化粧料

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JPH05320039A (ja) 1991-09-20 1993-12-03 Taiyo Kagaku Co Ltd 美白化粧料
JP2004051627A (ja) 2002-05-28 2004-02-19 Japan Natural Laboratory Co Ltd ビタミンｋ等を有効成分とするくすみ、くま、目下のたるみ、紫斑、打撲によるあざ、レーザー治療後の紫斑等の改善化粧料、全身化粧料、パック類およびその製造方法
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CN107397700A (zh) * 2017-06-12 2017-11-28 上海清轩生物科技有限公司 山茶花润肤油滋养化妆品及其制备方法
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Publication number Priority date Publication date Assignee Title
JPH1029929A (ja) * 1996-02-15 1998-02-03 Avon Prod Inc 目の下の皮膚のくすみをとるための合成物と方法
JP2004196759A (ja) * 2002-12-18 2004-07-15 Takashi Suzuki ビタミンｋ類とビタミンｅ複合の美肌化粧料

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JP7333606B2 (ja) 2023-08-25
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CN114727944A (zh) 2022-07-08

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