WO2021121154A1 - 一种新型试剂盒 - Google Patents

一种新型试剂盒 Download PDF

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Publication number
WO2021121154A1
WO2021121154A1 PCT/CN2020/135702 CN2020135702W WO2021121154A1 WO 2021121154 A1 WO2021121154 A1 WO 2021121154A1 CN 2020135702 W CN2020135702 W CN 2020135702W WO 2021121154 A1 WO2021121154 A1 WO 2021121154A1
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WO
WIPO (PCT)
Prior art keywords
liquid outlet
outlet pipe
box body
ball
sealing gasket
Prior art date
Application number
PCT/CN2020/135702
Other languages
English (en)
French (fr)
Inventor
郝书顺
Original Assignee
石家庄禾柏生物技术股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 石家庄禾柏生物技术股份有限公司 filed Critical 石家庄禾柏生物技术股份有限公司
Priority to EP20901027.1A priority Critical patent/EP4080223A4/en
Priority to JP2021576722A priority patent/JP7312349B2/ja
Priority to KR1020217041818A priority patent/KR20220010555A/ko
Priority to US17/626,897 priority patent/US20230349939A1/en
Publication of WO2021121154A1 publication Critical patent/WO2021121154A1/zh

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0666—Solenoid valves

Definitions

  • the invention relates to a test equipment, in particular to a novel kit.
  • the kit is a kind of test equipment commonly used in laboratories, which is used to store various liquid reagents used in some tests.
  • the tester needs to take out the reagent from the kit, the usual practice is to open the lid of the kit, and then use a syringe or dropper to suck a certain amount of the reagent, and then use it for the test operation. Because this process requires manual operation, if the tester is unskilled or careless, it is easy to contaminate his hands, body or test equipment. If the reagents used are corrosive or toxic, the consequences may be serious.
  • the technical problem to be solved by the present invention is to provide a new type of kit, which is used to solve the problem that the existing kit requires manual operation when in use.
  • a new type of reagent kit which includes a box body and a cylindrical liquid outlet tube fixed at the bottom of the box body, and a circular seal fixedly connected to the lower part of the inner wall of the liquid outlet tube
  • the sealing gasket is provided with a circular liquid outlet vertically penetrating its center, and the top of the liquid outlet is provided with a ball that can slide on the inner wall of the liquid outlet pipe, and the upper part of the ball is fixed with a liquid outlet
  • a magnetic rod sliding on the inner wall of the tube, the upper side of the outlet tube is provided with an electromagnetic coil fixedly connected to it, and the top of the box body is provided with a circular tube-shaped air inlet fixedly connected to the inside and outside of the tube .
  • the material of the sealing gasket is rubber.
  • the top center of the sealing gasket is provided with a spherical recess, the bottom of the spherical recess communicates with the liquid outlet, and the ball is compressed in the spherical recess by the magnetic rod.
  • the material of the ball is steel.
  • the bottom of the liquid outlet pipe is provided with a ring magnet fixedly connected to it.
  • the positive effect of the present invention is that the opening and closing actions of the liquid discharging device of the novel reagent box can be realized by the electric control system controlling the power on and off of the electromagnetic coil, so that there is no need to manually open the reagent box to take out the reagent and use it for the test operation.
  • the present invention can also provide reagents quantitatively, which can be realized by controlling the electrification time of the electromagnetic coil by the electronic control system according to the type of the reagent and the air pressure inside the reagent box and other parameters. Therefore, the new kit can also meet the requirements of the automatic test system.
  • Figure 1 is a schematic diagram of the structure of the present invention.
  • Figure 2 is a schematic diagram of the structure of the liquid outlet pipe.
  • the main structure of the novel reagent kit is a box body 6 which is closed on all sides, the air inlet 7 at the top of the box body 6 and the liquid outlet pipe 8 at the bottom of the box body 6.
  • the box body 6, the liquid outlet tube 8 and the air inlet 7 are all made of high-strength plastic or stainless steel.
  • the liquid outlet tube 8 is cylindrical, and the lower part of its inner wall is provided with a circular rubber seal fixedly connected to it.
  • the center of the sealing gasket 9 is provided with a circular liquid outlet 1 vertically penetrating its upper and lower surfaces, and the top of the liquid outlet 1 is provided with a steel ball 3, the diameter of the ball 3 is larger than the liquid outlet
  • the diameter of the mouth 1, the upper part of the ball 3 is provided with a magnetic rod 4 fixedly connected to it, and the ball 3 and the magnetic rod 4 can slide freely up and down inside the liquid outlet tube 8.
  • the top center of the sealing gasket 9 is provided with a spherical recess, and the bottom of the recess communicates with the liquid outlet 1.
  • An electromagnetic coil 5 fixedly connected to the liquid outlet tube 8 is provided on the outer upper side thereof.
  • the bottom of the liquid outlet pipe 8 is provided with a ring magnet 2 fixedly connected to it.
  • the box body 6 contains reagents for experiments, and the air inlet 7 connects the inside of the box body 6 with an external air source, so that the inside of the box body 6 can maintain a certain air pressure.
  • the electromagnetic coil 5 When the electromagnetic coil 5 is de-energized, the ball 3 and the magnetic rod 4 fixedly connected to it can reliably hold the liquid outlet 1 under the action of gravity, the attraction of the ring magnet 2 and the pressure of the liquid inside the box 6 Blocking; when the electromagnetic coil 5 is energized, it produces an electromagnetic attraction force on the magnetic rod 4 and the ball 3, the electromagnetic attraction force is greater than the gravity acting on the magnetic rod 4 and the ball 3, the ring magnet 2
  • the sum of the attractive force and the pressure inside the box 6, so the magnetic rod and the ball 3 will slide upwards along the inner wall of the liquid outlet tube 8 under the electromagnetic attraction of the electromagnetic coil 5, so that the ball 3 and the liquid outlet 1 is separated, the reagent inside the box body 6 will be discharged through the liquid outlet 1.
  • the gap between the ball 3 and the liquid outlet tube 8 are all fixed values, the size of the hole in the center of the gasket 9 and the inner hole of the liquid outlet 8 are also the same. It is a fixed value, so the amount of reagent flowing out of the box body 6 per unit time is related to the air pressure inside the box body 6 and the viscosity of the reagent. Therefore, when the air pressure inside the box body 6 and the viscosity of the reagent are known, the release amount of the reagent inside the box body 6 can be controlled by controlling the power-on time of the solenoid 5, so that this new type of reagent kit is more suitable for an automatic test system.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Medicinal Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

一种试剂盒，包括环形磁铁(2)、圆珠(3)、磁棒(4)、电磁线圈(5)、盒体(6)、进气口(7)、出液管(8)和密封垫(9)；出液管(8)位于盒体(6)底面，出液管(8)顶部与盒体(6)固定，出液管(8)中部有圆柱形的磁棒(4)，磁棒(4)底部与圆珠(3)为固定连接；出液管(8)下部的孔内有圆形的密封垫(9)，密封垫(9)顶部中心有球面凹坑，凹坑底部有出液口(1)；圆珠(3)底部与密封垫(9)顶部的球面凹坑配合并贴紧，环形磁铁(2)固定在出液管(8)底面，电磁线圈(5)固定在出液管(8)外面。试剂盒无需人工打开试剂盒取出试剂再用于试验操作，可满足自动测试系统的要求。

Description

一种新型试剂盒 技术领域
本发明涉及一种试验器材，特别涉及一种新型试剂盒。
 背景技术
试剂盒是一种实验室常用的试验器材，用于存放一些试验中所使用的各种各样的液体试剂。当在试验人员需要从试剂盒中取出试剂时，通常的做法是需要试验人员打开试剂盒的盖子，然后使用注射器或滴管吸取一定量的试剂，然后再用于试验操作。因为此过程需要人工操作，试验人员如果操作不熟练或不注意还容易污染到手上、身上或试验设备上。如果所使用的试剂具有一定的腐蚀性或毒性，后果就可能会很严重。
 技术问题
本发明所要解决的技术问题是提供一种新型试剂盒，用于解决现有试剂盒在使用时需要人工操作的问题。
 技术解决方案
本发明所采用的技术方案是：一种新型试剂盒，其包括盒体和固定在其底部的圆筒形的出液管，所述出液管内壁下部设有与其固定连接的圆形的密封垫，所述密封垫设有垂直贯穿其中心的圆形的出液口，所述出液口顶部设有可在出液管内壁滑动的圆珠，所述圆珠上部固定有可在出液管内壁滑动的磁棒，所述出液管外部上侧设有与其固定连接的电磁线圈，所述的盒体顶部设有与其固定连接的可连通其内部和外部的圆管形的进气口。
进一步的，所述的密封垫材质为橡胶。
进一步的，所述的密封垫顶部中心设有球形的凹坑，所述的球形凹坑底部与出液口相通，所述的圆珠被磁棒压紧在球形凹坑内。
进一步的，所述的圆珠材质为钢。
进一步的，所述的出液管底部设有与其固定连接的环形磁铁。
 有益效果
本发明的积极效果为：新型试剂盒的出液装置打开和关闭动作可以由电控系统控制电磁线圈的得电与失电来实现，从而无需人工打开试剂盒取出试剂再用于试验操作。本发明也可定量提供试剂，可由电控系统根据试剂的类型和试剂盒内部的气压等参数通过控制电磁线圈的得电时间来实现。因而本新型试剂盒也可满足自动测试系统的要求。
 附图说明
图1是本发明的结构示意图。
图2是出液管部位的结构示意图。
图中，1、出液口；2、环形磁铁；3、圆珠；4、磁棒；5、电磁线圈；6、盒体；7、进气口；8、出液管；9、密封垫。
 本发明的实施方式
如图1和图2所示，新型试剂盒主要结构为四周密闭的盒体6，所述的盒体6顶部的进气口7和盒体6底部的出液管8。所述盒体6、出液管8和进气口7均采用高强度塑料或不锈钢制作，所述的出液管8为圆筒形，其内壁下部设有与其固定连接的圆形的橡胶密封垫9，所述密封垫9中心设有垂直贯穿其上下表面的圆形的出液口1，所述出液口1顶部设有钢质的圆珠3，所述圆珠3直径大于出液口1直径，所述圆珠3上部设有与其固定连接的磁棒4，所述的圆珠3和磁棒4可在出液管8内部上下自由滑动。所述的密封垫9顶部中心设有球形的凹坑，该凹坑底部与出液口1相通。所述出液管8外部上侧设有与其固定连接的电磁线圈5。所述的出液管8底部设有与其固定连接的环形磁铁2。所述盒体6内部装有用于实验的试剂，所述进气口7将盒体6内部和外接气源连通，可使盒体6内部保持一定的气压。当所述电磁线圈5失电后，所述的圆珠3和与其固定连接的磁棒4在重力、环形磁铁2的吸引以及盒体6内部液体的压力作用下可将出液口1可靠的封堵；当所述电磁线圈5得电后，其对磁棒4和圆珠3产生电磁吸引力，所述电磁吸引力大于作用在磁棒4和圆珠3上的重力、环形磁铁2的吸引力和盒体6内部的压力之和，因此所述磁棒和圆珠3会在电磁线圈5的电磁吸引力作用下沿出液管8内壁向上滑动，从而使圆珠3和出液口1分离，所述盒体6内部的试剂会通过出液口1排出。
由于所述出液管8与磁棒4，圆珠3与出液管8之间的间隙为均为固定值，所述密封垫9中心的孔和出液口8内部的各孔尺寸也均为固定值，因此单位时间内从所述盒体6内部流出的试剂的量与盒体6内部气压和试剂的黏度有关。因此，在已知盒体6内部气压和试剂的黏度时，可通过控制电磁线圈5的得电时间来控制盒体6内部试剂的释放量，从而此新型试剂盒更加适合自动测试系统。

Claims (5)

  1. 一种新型试剂盒，其特征在于，其包括盒体（6）和固定在其底部的圆筒形的出液管（8），所述出液管（8）内壁下部设有与其固定连接的圆形的密封垫（9），所述密封垫（9）设有垂直贯穿其中心的圆形的出液口（1），所述出液口（1）顶部设有可在出液管（8）内壁滑动的圆珠（3），所述圆珠（3）上部固定有可在出液管（8）内壁滑动的磁棒（4），所述出液管（8）外部上侧设有与其固定连接的电磁线圈（5），所述的盒体（6）顶部设有与其固定连接的可连通其内部和外部的圆管形的进气口（7）。
  2. 根据权利要求1所述的新型试剂盒，其特征在于，所述的密封垫（9）材质为橡胶。
  3. 根据权利要求1所述的新型试剂盒，其特征在于，所述的密封垫（9）顶部中心设有球形的凹坑，所述的球形凹坑底部与出液口（1）相通，所述的圆珠（3）被磁棒（4）压紧在球形凹坑内。
  4. 根据权利要求1所述的新型试剂盒，其特征在于，所述的圆珠（3）材质为钢。
  5. 根据权利要求1所述的新型试剂盒，其特征在于，所述的出液管（8）底部设有与其固定连接的环形磁铁（2）。
PCT/CN2020/135702 2019-12-19 2020-12-11 一种新型试剂盒 WO2021121154A1 (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP20901027.1A EP4080223A4 (en) 2019-12-19 2020-12-11 NEW TEST KIT
JP2021576722A JP7312349B2 (ja) 2019-12-19 2020-12-11 新型試薬キット
KR1020217041818A KR20220010555A (ko) 2019-12-19 2020-12-11 신형 키트
US17/626,897 US20230349939A1 (en) 2019-12-19 2020-12-11 Novel Test Kit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911314110.4 2019-12-19
CN201911314110.4A CN111308110A (zh) 2019-12-19 2019-12-19 一种新型试剂盒

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Publication Number Publication Date
WO2021121154A1 true WO2021121154A1 (zh) 2021-06-24

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US (1) US20230349939A1 (zh)
EP (1) EP4080223A4 (zh)
JP (1) JP7312349B2 (zh)
KR (1) KR20220010555A (zh)
CN (1) CN111308110A (zh)
WO (1) WO2021121154A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111308110A (zh) * 2019-12-19 2020-06-19 石家庄禾柏生物技术股份有限公司 一种新型试剂盒
CN112067366B (zh) * 2020-10-23 2023-02-24 中国人民解放军总医院第八医学中心 一种临床药学用快速取样装置
CN112526153A (zh) * 2020-11-23 2021-03-19 石家庄禾柏生物技术股份有限公司 试剂盒
CN112431930A (zh) 2020-11-23 2021-03-02 石家庄禾柏生物技术股份有限公司 一种密封阀及包含该密封阀的出液结构
CN112520182A (zh) * 2020-11-23 2021-03-19 石家庄禾柏生物技术股份有限公司 一种试剂盒进气结构
CN112547329A (zh) 2020-11-23 2021-03-26 石家庄禾柏生物技术股份有限公司 一种试剂盒出液装置

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