WO2021120610A1 - 高度可调的色谱柱温度均匀器 - Google Patents

高度可调的色谱柱温度均匀器 Download PDF

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Publication number
WO2021120610A1
WO2021120610A1 PCT/CN2020/101549 CN2020101549W WO2021120610A1 WO 2021120610 A1 WO2021120610 A1 WO 2021120610A1 CN 2020101549 W CN2020101549 W CN 2020101549W WO 2021120610 A1 WO2021120610 A1 WO 2021120610A1
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WO
WIPO (PCT)
Prior art keywords
chromatographic column
block
conduction block
chromatography column
height
Prior art date
Application number
PCT/CN2020/101549
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English (en)
French (fr)
Inventor
黄彦
邱一华
苏建友
彭聿平
方小霞
Original Assignee
南通大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 南通大学 filed Critical 南通大学
Priority to PCT/CN2020/101549 priority Critical patent/WO2021120610A1/zh
Publication of WO2021120610A1 publication Critical patent/WO2021120610A1/zh
Priority to ZA2021/04658A priority patent/ZA202104658B/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
    • G01N30/54—Temperature

Definitions

  • the invention relates to a chromatographic column temperature homogenizer used in a chromatographic column thermostat of a high-performance liquid chromatograph.
  • the existing chromatographic column temperature homogenizer has the problem of unsatisfactory temperature uniformity.
  • One of the reasons is that the temperature homogenizer cannot be in close contact with the chromatographic column thermostat of the liquid chromatograph, which leads to unsatisfactory heat absorption and dissipation.
  • the purpose of the present invention is to provide a highly adjustable chromatographic column temperature homogenizer with good temperature uniformity.
  • a height-adjustable chromatographic column temperature homogenizer comprising an upper metal heat conduction block, a lower metal heat conduction block, an upper metal heat conduction block, a lower metal heat conduction block connected by a hinge, an upper metal heat conduction block and a lower metal heat conduction block
  • Multiple upper semicircular chromatographic column grooves and multiple lower semicircular chromatographic column grooves are respectively set on the block, and the number of upper semicircular chromatographic column grooves and lower semicircular chromatographic column grooves are the same, and the positions are correspondingly set;
  • the length of the circular chromatographic column slot and the lower semicircular column slot is greater than the length of the chromatographic column; it is characterized in that: a metal height packing block is placed on the upper surface of the upper metal heat conduction block, and the thickness of the metal height packing block is such that the entire chromatographic column
  • the height of the temperature homogenizer is the same as that of the inner cavity of the chromatographic column thermostat of the liquid chromatograph.
  • the upper metal heat conduction block and the lower metal heat conduction block are locked tightly by the buckle lock.
  • the structure of the invention is reasonable, and the working temperature of the chromatographic column is kept consistent, stable and uniform through the arrangement of the metal height packing block.
  • Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
  • a height-adjustable chromatographic column temperature homogenizer comprising an upper metal heat conduction block 1, a lower metal heat conduction block 2, an upper metal heat conduction block, a lower metal heat conduction block are linked by a hinge 3, an upper metal heat conduction block, a lower metal heat conduction block
  • a plurality of upper semicircular chromatographic column grooves 4 and a plurality of lower semicircular chromatographic column grooves 5 are respectively set on the sheet metal heat conducting block, and the number and position of the upper semicircular chromatographic column grooves and the lower semicircular chromatographic column grooves are the same.
  • the length of the upper semicircular column slot and the lower semicircular column slot is greater than the length of the column; the metal height packing block 7 is placed on the upper surface of the upper metal heat conduction block, and the thickness of the metal height packing block is so that the entire The height of the chromatographic column temperature homogenizer is the same as the height of the inner cavity of the chromatographic column thermostat of the liquid chromatograph.
  • the upper metal heat-conducting block and the lower metal heat-conducting block are fastened and locked by the buckle lock 6.
  • the metal height filling block can have multiple blocks with different thicknesses, which can be selected and used according to the needs.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

一种高度可调的色谱柱温度均匀器，包括上片金属导热块（1）、下片金属导热块（2），上片金属导热块（1）、下片金属导热块（2）通过铰链（3）链接，上片金属导热块（1）、下片金属导热块（2）上分别设置多条上半圆形色谱柱槽（4）和多条下半圆形色谱柱槽（5），且上半圆形色谱柱槽（4）和下半圆形色谱柱槽（5）的数量相同、位置对应设置；上半圆形色谱柱槽（4）和下半圆形色谱柱槽（5）的长度大于色谱柱长度；在上片金属导热块（1）的上表面放置金属高度填充块（7），金属高度填充块（7）的厚度为使整个色谱柱温度均匀器的高度与液相色谱仪色谱柱恒温箱内腔高度相同；金属高度填充块（7）的设置有效保持了色谱柱工作温度的一致、稳定和均匀。

Description

高度可调的色谱柱温度均匀器 技术领域
本发明涉及一种在高效液相色谱仪色谱柱恒温箱中使用的色谱柱温度均匀器。
 背景技术
现有的色谱柱温度均匀器存在温度均匀性不理想的问题，原因之一是温度均匀器不能液相色谱仪色谱柱恒温箱紧密接触，导致热量吸收、散发不理想。
 技术问题
本发明的目的在于提供一种温度均匀性能好的高度可调的色谱柱温度均匀器。
 技术解决方案
一种高度可调的色谱柱温度均匀器，包括上片金属导热块、下片金属导热块，上片金属导热块、下片金属导热块通过铰链链接，上片金属导热块、下片金属导热块上分别设置多条上半圆形色谱柱槽和多条下半圆形色谱柱槽，且上半圆形色谱柱槽和下半圆形色谱柱槽的数量相同、位置对应设置；上半圆形色谱柱槽和下半圆形色谱柱槽的长度大于色谱柱长度；其特征是：在上片金属导热块的上表面放置金属高度填充块，金属高度填充块的厚度为使整个色谱柱温度均匀器的高度与液相色谱仪色谱柱恒温箱内腔高度相同。
使用时，上片金属导热块、下片金属导热块通过扣合锁扣紧锁定。
金属高度填充块有不同厚度的多块，根据需要选择使用。
 有益效果
本发明结构合理，通过金属高度填充块的设置，有效保持了色谱柱工作温度的一致、稳定和均匀。
 附图说明
图1是本发明一个实施例的结构示意图。
 本发明的最佳实施方式
一种高度可调的色谱柱温度均匀器，包括上片金属导热块1、下片金属导热块2，上片金属导热块、下片金属导热块通过铰链3链接，上片金属导热块、下片金属导热块上分别设置多条上半圆形色谱柱槽4和多条下半圆形色谱柱槽5，且上半圆形色谱柱槽和下半圆形色谱柱槽的数量相同、位置对应设置；上半圆形色谱柱槽和下半圆形色谱柱槽的长度大于色谱柱长度；在上片金属导热块的上表面放置金属高度填充块7，金属高度填充块的厚度为使整个色谱柱温度均匀器的高度与液相色谱仪色谱柱恒温箱内腔高度相同。
使用时，上片金属导热块、下片金属导热块通过扣合锁6扣紧锁定。
金属高度填充块可以有不同厚度的多块，根据需要选择使用。

Claims (3)

  1. 一种高度可调的色谱柱温度均匀器，包括上片金属导热块、下片金属导热块，上片金属导热块、下片金属导热块通过铰链链接，上片金属导热块、下片金属导热块上分别设置多条上半圆形色谱柱槽和多条下半圆形色谱柱槽，且上半圆形色谱柱槽和下半圆形色谱柱槽的数量相同、位置对应设置；上半圆形色谱柱槽和下半圆形色谱柱槽的长度大于色谱柱长度；其特征是：在上片金属导热块的上表面放置金属高度填充块，金属高度填充块的厚度为使整个色谱柱温度均匀器的高度与液相色谱仪色谱柱恒温箱内腔高度相同。
  2. 根据权利要求1所述的高度可调的色谱柱温度均匀器，其特征是：使用时，上片金属导热块、下片金属导热块通过扣合锁扣紧锁定。
  3. 根据权利要求1或2所述的高度可调的色谱柱温度均匀器，其特征是：金属高度填充块有不同厚度的多块，根据需要选择使用。
PCT/CN2020/101549 2020-07-13 2020-07-13 高度可调的色谱柱温度均匀器 WO2021120610A1 (zh)

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PCT/CN2020/101549 WO2021120610A1 (zh) 2020-07-13 2020-07-13 高度可调的色谱柱温度均匀器
ZA2021/04658A ZA202104658B (en) 2020-07-13 2021-07-05 Highly-adjustable chromatography column temperature equalizer

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5983710A (en) * 1997-11-24 1999-11-16 Brinkman Instruments, Inc. Modular chromatography column heating system
CN102890133A (zh) * 2012-10-19 2013-01-23 南通大学 多根不同长度色谱柱为一体的温度均匀器
CN102901785A (zh) * 2012-10-22 2013-01-30 南通大学 不同长度和柱径的多根色谱柱为一体的温度均匀器
CN102914611A (zh) * 2012-10-12 2013-02-06 南通大学 多根色谱柱为一体的温度均匀器
CN103439439A (zh) * 2012-10-22 2013-12-11 南通大学 工作温度稳定、均匀的色谱柱温度均匀器
CN103869031A (zh) * 2012-10-19 2014-06-18 南通大学 保持色谱柱工作温度均匀的温度均匀器
CN204758554U (zh) * 2015-06-30 2015-11-11 杭州春来科技有限公司 一种微小型色谱柱温控装置
CN206799487U (zh) * 2017-05-17 2017-12-26 中国农业科学院兰州兽医研究所 一种蛋白纯化柱的保温固定装置
CN109406694A (zh) * 2018-12-19 2019-03-01 江苏汉邦科技有限公司 一种用于超临界流体色谱系统的色谱柱温控装置

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5983710A (en) * 1997-11-24 1999-11-16 Brinkman Instruments, Inc. Modular chromatography column heating system
CN102914611A (zh) * 2012-10-12 2013-02-06 南通大学 多根色谱柱为一体的温度均匀器
CN102890133A (zh) * 2012-10-19 2013-01-23 南通大学 多根不同长度色谱柱为一体的温度均匀器
CN103869031A (zh) * 2012-10-19 2014-06-18 南通大学 保持色谱柱工作温度均匀的温度均匀器
CN102901785A (zh) * 2012-10-22 2013-01-30 南通大学 不同长度和柱径的多根色谱柱为一体的温度均匀器
CN103439439A (zh) * 2012-10-22 2013-12-11 南通大学 工作温度稳定、均匀的色谱柱温度均匀器
CN204758554U (zh) * 2015-06-30 2015-11-11 杭州春来科技有限公司 一种微小型色谱柱温控装置
CN206799487U (zh) * 2017-05-17 2017-12-26 中国农业科学院兰州兽医研究所 一种蛋白纯化柱的保温固定装置
CN109406694A (zh) * 2018-12-19 2019-03-01 江苏汉邦科技有限公司 一种用于超临界流体色谱系统的色谱柱温控装置

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