WO2021114811A1 - 一种具有抗菌高吸收的医用敷料及其制备方法 - Google Patents

一种具有抗菌高吸收的医用敷料及其制备方法 Download PDF

Info

Publication number
WO2021114811A1
WO2021114811A1 PCT/CN2020/116843 CN2020116843W WO2021114811A1 WO 2021114811 A1 WO2021114811 A1 WO 2021114811A1 CN 2020116843 W CN2020116843 W CN 2020116843W WO 2021114811 A1 WO2021114811 A1 WO 2021114811A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial
layer
strips
medical dressing
dressing
Prior art date
Application number
PCT/CN2020/116843
Other languages
English (en)
French (fr)
Inventor
应俊
Original Assignee
浙江惠龙医疗科技股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 浙江惠龙医疗科技股份有限公司 filed Critical 浙江惠龙医疗科技股份有限公司
Publication of WO2021114811A1 publication Critical patent/WO2021114811A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

Definitions

  • the technical field of medical dressings related to the present invention is specifically a medical dressing with antibacterial and high absorption and a preparation method thereof.
  • Medical dressings include natural gauze, synthetic fiber dressings, polymembrane dressings, foamed multi-cluster dressings, hydrocolloid dressings, alginate dressings, medical materials used to cover sores, wounds or other damages.
  • the in-depth study of the pathophysiology of the wound healing process has led to a deeper and deeper understanding of the wound healing process, which has led to the continuous improvement and development of medical wound dressings.
  • Today, new-type wound care dressings have been compared with the earlier ones. Revolutionary changes have taken place, and a variety of medical dressings with different properties are available for clinical nurses to choose;
  • the present invention provides a medical dressing with antibacterial and high absorption and a preparation method thereof, which can effectively solve the problem of antibacterial and high absorption of medical dressings currently on the market proposed in the background art, which cannot facilitate normal human skin.
  • a medical dressing with antibacterial and high absorption including natural gauze
  • the bottom end of the natural gauze is provided with antibacterial warp strips and antibacterial weft strips
  • the antibacterial warp strips and antibacterial wefts The strips are woven across each other
  • a fiber layer is bonded under the antibacterial warp strips and the antibacterial weft strips
  • a collagen layer is arranged at the bottom end of the fiber layer
  • an inverted triangle is arranged between the fiber layer and the collagen layer
  • the collagen layer The bottom end is provided with a composite dressing, and an antibacterial absorption layer is embedded in the middle of the composite dressing.
  • the ratio of the antibacterial warp strips and the antibacterial weft strips is: -.
  • the antibacterial absorption layer has a square shape, and a chamfer is provided at the top edge.
  • the antibacterial warp strips and the antibacterial weft strips are both silver-containing dressings.
  • a preparation method of a medical dressing with antibacterial and high absorption includes the following steps:
  • a compound dressing is applied to the center of the medical dressing
  • the fiber layer is sodium carboxymethyl cellulose fiber
  • the preparation method of the sodium carboxymethyl cellulose fiber is as follows:
  • the cotton pulp that has been ground into powder is sent to a vertical alkalization machine equipped with isopropanol, and sodium hydroxide solution is added while stirring for alkalization;
  • the concentration of the sodium hydroxide solution is 40%-50%, and the alkalization temperature is 15-25 degrees Celsius.
  • the composite dressing includes the use of alginic acid fibers, water-soluble polymers, non-woven textile materials, polyurethane foams and films to form materials with both hygroscopicity and protective properties through various combinations of forms.
  • the antibacterial absorption layer is a combination of sodium carboxymethyl cellulose fiber and alginate
  • the preparation steps of the alginate are as follows:
  • the stirring speed is 10-15r/min, and the stirring time is 10-15s;
  • the stirring speed is 60-120 r/min, and the stirring time is 50-70s.
  • the ratio of sodium alginate to potassium alginate is 1: (0.9-1.3).
  • the present invention has beneficial effects: the structure of the present invention is scientific and reasonable, safe and convenient to use, natural gauze can be used to quickly absorb wound exudate, and antibacterial warp strips and antibacterial weft strips can be woven together, which can facilitate one step further It can improve the toughness of the dressing, and the antibacterial warp strips and antibacterial weft strips can also ensure the further antibacterial properties of the medical dressing.
  • the fiber layer adopts sodium carboxymethyl cellulose fiber and the collagen layer to cooperate with each other, which can facilitate the promotion of skin tissue anabolism and cell Regeneration, increase the local temperature and humidity of the skin, accelerate the blood circulation and metabolism of local skin cells, which is beneficial to the regeneration of skin cells, thereby accelerating tissue regeneration and repair.
  • the main raw materials of alginate dressings are methyl sodium carbonate cellulose and algae.
  • the main feature of calcium acid is that it has high hygroscopicity, gelation and hemostatic properties, so as to facilitate the healing of normal skin.
  • Figure 1 is a schematic diagram of the structure of the present invention
  • FIG. 2 is a schematic diagram of the installation structure of the antibacterial warp strip and the antibacterial weft strip of the present invention
  • Figure 3 is a schematic sectional view of the present invention.
  • Figure 4 is a schematic diagram of the preparation process of the medical dressing of the present invention.
  • Figure 5 is a schematic diagram of the process structure of the preparation method of sodium carboxymethyl cellulose fiber of the present invention.
  • Figure 6 is a schematic diagram of the preparation process of the antibacterial absorbent layer of the present invention.
  • Example 1 As shown in Figures 1-3, the present invention provides a technical solution, a medical dressing with antibacterial and high absorption, comprising natural gauze 1, with antibacterial warp strips 2 and antibacterial weft strips 3 provided at the bottom end of the natural gauze 1, Antibacterial warp strips 2 and antibacterial weft strips 3 are both silver-containing dressings. Antibacterial warp strips 2 and antibacterial weft strips 3 are interlaced with each other. The ratio of antibacterial warp strips 2 and antibacterial weft strips 3 is 4:7.
  • Antibacterial warp strips 2 and The fiber layer 4 is bonded under the antibacterial weft strip 3, the bottom end of the fiber layer 4 is provided with a collagen layer 5, an inverted triangle 6 is provided between the fiber layer 4 and the collagen layer 5, and the bottom end of the collagen layer 5 is provided with a composite dressing 7.
  • An antibacterial absorption layer 8 is embedded in the middle of the composite dressing 7, and the antibacterial absorption layer 8 is square, and the top edge is provided with a chamfer.
  • the natural gauze 1 can facilitate the rapid absorption of wound exudate
  • the antibacterial warp strips 2 and the antibacterial weft strips 3 are mutually woven, which can facilitate the further improvement of the toughness of the dressing and the antibacterial
  • the warp strip 2 and the antibacterial weft strip 3 can also ensure the further antibacterial properties of the medical dressing
  • the fiber layer 4 uses sodium carboxymethyl cellulose fiber and the collagen layer 5 to cooperate with each other, which can facilitate skin tissue anabolism and cell regeneration, and improve skin Local temperature and humidity accelerate the blood circulation and metabolism of local skin cells, which is conducive to the renewal of skin cells, thereby accelerating tissue regeneration and repair.
  • the main raw materials of alginate dressings are methyl sodium carbonate cellulose and calcium alginate. It is characterized by high hygroscopicity, gelation and hemostatic properties, which facilitates the healing of normal skin.
  • Example 2 As shown in Figures 1-3, the present invention provides a technical solution, a medical dressing with antibacterial and high absorption, comprising natural gauze 1, with antibacterial warp strips 2 and antibacterial weft strips 3 provided at the bottom end of the natural gauze 1, Antibacterial warp strips 2 and antibacterial weft strips 3 are both silver-containing dressings. Antibacterial warp strips 2 and antibacterial weft strips 3 are woven cross each other. The ratio of antibacterial warp strips 2 and antibacterial weft strips 3 is 4:5.
  • the fiber layer 4 is bonded under the antibacterial weft strip 3, the bottom end of the fiber layer 4 is provided with a collagen layer 5, an inverted triangle 6 is provided between the fiber layer 4 and the collagen layer 5, and the bottom end of the collagen layer 5 is provided with a composite dressing 7.
  • An antibacterial absorption layer 8 is embedded in the middle of the composite dressing 7, and the antibacterial absorption layer 8 is square, and the top edge is provided with a chamfer.
  • the natural gauze 1 can facilitate the rapid absorption of wound exudate, and the antibacterial warp strips 2 and the antibacterial weft strips 3 are mutually weaved, which can facilitate the further improvement of the toughness of the dressing and has antibacterial properties.
  • the warp strip 2 and the antibacterial weft strip 3 can also ensure the further antibacterial properties of the medical dressing, and the fiber layer 4 uses sodium carboxymethyl cellulose fiber and the collagen layer 5 to cooperate with each other, which can facilitate skin tissue anabolism and cell regeneration, and improve skin Local temperature and humidity accelerate the blood circulation and metabolism of local skin cells, which is conducive to the replacement of skin cells, thereby accelerating tissue regeneration and repair.
  • the main raw materials of alginate dressings are methyl sodium carbonate cellulose and calcium alginate. It is characterized by high hygroscopicity, gelation and hemostatic properties, which facilitates the healing of normal skin.
  • Embodiment 3 As shown in Figures 1-3, the present invention provides a technical solution, a medical dressing with antibacterial and high absorption, including natural gauze 1, with antibacterial warp strips 2 and antibacterial weft strips 3 provided at the bottom end of the natural gauze 1, Antibacterial warp strips 2 and antibacterial weft strips 3 are both silver-containing dressings. Antibacterial warp strips 2 and antibacterial weft strips 3 are interlaced with each other. The ratio of antibacterial warp strips 2 and antibacterial weft strips 3 is 4:6.
  • Antibacterial warp strips 2 and The fiber layer 4 is bonded under the antibacterial weft strip 3, the bottom end of the fiber layer 4 is provided with a collagen layer 5, an inverted triangle 6 is provided between the fiber layer 4 and the collagen layer 5, and the bottom end of the collagen layer 5 is provided with a composite dressing 7.
  • An antibacterial absorption layer 8 is embedded in the middle of the composite dressing 7, and the antibacterial absorption layer 8 is square, and the top edge is provided with a chamfer.
  • the natural gauze 1 can facilitate the rapid absorption of wound exudate, and the antibacterial warp strips 2 and the antibacterial weft strips 3 are mutually weaved, which can facilitate the further improvement of the toughness of the dressing and has antibacterial properties.
  • the warp strip 2 and the antibacterial weft strip 3 can also ensure the further antibacterial properties of the medical dressing, and the fiber layer 4 uses sodium carboxymethyl cellulose fiber and the collagen layer 5 to cooperate with each other, which can facilitate skin tissue anabolism and cell regeneration, and improve skin Local temperature and humidity accelerate the blood circulation and metabolism of local skin cells, which is conducive to the replacement of skin cells, thereby accelerating tissue regeneration and repair.
  • the main raw materials of alginate dressings are methyl sodium carbonate cellulose and calcium alginate. It is characterized by high hygroscopicity, gelation and hemostatic properties, which facilitates the healing of normal skin.
  • Embodiment 4 As shown in Figures 4-6, the present invention provides a technical solution, a method for preparing a medical dressing with antibacterial and high absorption, including the following steps:
  • a compound dressing is applied to the center of the medical dressing
  • the fiber layer is sodium carboxymethyl cellulose fiber
  • the preparation method of the sodium carboxymethyl cellulose fiber is as follows:
  • the cotton pulp that has been ground into powder is sent to a vertical alkalization machine equipped with isopropanol, and sodium hydroxide solution is added while stirring for alkalization;
  • the concentration of the sodium hydroxide solution is 50%, and the alkalization temperature is 18 degrees Celsius.
  • the composite dressing includes the use of alginic acid fibers, water-soluble polymers, non-woven textile materials, polyurethane foams and films to form materials with both hygroscopicity and protective properties through various combinations of forms.
  • the antibacterial absorption layer is a combination of sodium carboxymethyl cellulose fiber and alginate
  • the preparation steps of the alginate are as follows:
  • the stirring speed is 15r/min, and the stirring time is 10s;
  • the stirring speed is 100r/min, and the stirring time is 60s.
  • the ratio of sodium alginate to potassium alginate is 1:1.
  • Embodiment 5 As shown in Figures 4-6, the present invention provides a technical solution, a method for preparing a medical dressing with antibacterial and high absorption, including the following steps:
  • a compound dressing is applied to the center of the medical dressing
  • the fiber layer is sodium carboxymethyl cellulose fiber
  • the preparation method of the sodium carboxymethyl cellulose fiber is as follows:
  • the cotton pulp that has been ground into powder is sent to a vertical alkalization machine equipped with isopropanol, and sodium hydroxide solution is added while stirring for alkalization;
  • the concentration of the sodium hydroxide solution is 45%, and the alkalization temperature is 19 degrees Celsius.
  • the composite dressing includes the use of alginic acid fibers, water-soluble polymers, non-woven textile materials, polyurethane foams and films to form materials with both hygroscopicity and protective properties through various combinations of forms.
  • the antibacterial absorption layer is a combination of sodium carboxymethyl cellulose fiber and alginate
  • the preparation steps of the alginate are as follows:
  • the stirring speed is 12r/min, and the stirring time is 13s;
  • the stirring speed is 7r/min, and the stirring time is 70s.
  • the ratio of sodium alginate to potassium alginate is 1:0.9.
  • Example 6 As shown in Figures 4-6, the present invention provides a technical solution, a method for preparing a medical dressing with antibacterial and high absorption, including the following steps:
  • a compound dressing is applied to the center of the medical dressing
  • the fiber layer is sodium carboxymethyl cellulose fiber
  • the preparation method of the sodium carboxymethyl cellulose fiber is as follows:
  • the cotton pulp that has been ground into powder is sent to a vertical alkalization machine equipped with isopropanol, and sodium hydroxide solution is added while stirring for alkalization;
  • the concentration of the sodium hydroxide solution is 40%, and the alkalization temperature is 23 degrees Celsius.
  • the composite dressing includes the use of alginic acid fibers, water-soluble polymers, non-woven textile materials, polyurethane foams and films to form materials with both hygroscopicity and protective properties through various combinations of forms.
  • the antibacterial absorption layer is a combination of sodium carboxymethyl cellulose fiber and alginate
  • the preparation steps of the alginate are as follows:
  • the stirring speed is 14r/min, and the stirring time is 12s;
  • the stirring speed is 115r/min, and the stirring time is 55s.
  • the ratio of sodium alginate to potassium alginate is 1:1.2.
  • Example 1 has more efficient antibacterial rate and absorption rate, and can be more suitable for promotion in production.

Abstract

一种具有抗菌高吸收的医用敷料，包括天然纱布(1)，所述天然纱布(1)底端设置有抗菌经条(2)和抗菌纬条(3)，所述抗菌经条(2)和抗菌纬条(3)相互交叉纺织，所述抗菌经条(2)和抗菌纬条(3)下方粘接有纤维层(4)，所述纤维层(4)底端设置有胶原层(5)，结构科学合理，使用安全方便，通过天然纱布(1)可以便于快速吸收创面渗出液，通过抗菌经条(2)和抗菌纬条(3)相互纺织，可以便于更一步的提高敷料的韧性，并且抗菌经条(2)和抗菌纬条(3)也可以保证医用敷料的进一步抗菌性，而纤维层(4)采用羧甲基纤维素钠纤维和胶原层(5)相互配合，可以便于促进皮肤组织合成代谢和细胞再生，提高皮肤局部温度和湿度，加速局部皮肤细胞的血液循环和新陈代谢。

Description

一种具有抗菌高吸收的医用敷料及其制备方法 技术领域
本发明涉及的医用敷料技术领域，具体为一种具有抗菌高吸收的医用敷料及其制备方法。
背景技术
医用敷料包括天然纱布、合成纤维类敷料、多聚膜类敷料、发泡多聚类敷料、水胶体类敷料、藻酸盐敷料，用以覆盖疮、伤口或其他损害的医用材料，随着对创面愈合过程的病理生理的深入研究，人们对创面愈合过程的理解也越来越深刻，从而导致了医用创面敷料的不断改进与发展，今天，新型的创面护理用敷料相对于早期而言，已经发生了革命性的变化，而且多种不同性能的医用敷料可供临床护理人员选用；
但是目前市场上的医用敷料在抗菌和高吸收方面仍然有很大的欠缺，不能便于人体肌肤的正常贴合与后期的痊愈，降低伤口感染率的现象。
发明内容
本发明提供一种具有抗菌高吸收的医用敷料及其制备方法，可以有效解决上述背景技术中提出目前市场上的医用敷料在抗菌和高吸收方面仍然有很大的欠缺，不能便于人体肌肤的正常贴合与后期的痊愈，降低伤口感染率的现象的问题。
为实现上述目的，本发明提供如下技术方案：一种具有抗菌高吸收的医用敷料，包括天然纱布，所述天然纱布底端设置有抗菌经条和抗菌纬条，所述抗菌经条和抗菌纬条相互交叉纺织，所述抗菌经条和抗菌纬条下方粘接有纤维层，所述纤维层底端设置有胶原层，所述纤维层和胶原层之间设置有倒三角，所述胶原层底端设置有复合型敷料，所述复合型敷料中间嵌入有抗菌吸收层。
根据上述技术方案，所述抗菌经条和抗菌纬条的案子比例为:-。
根据上述技术方案，所述抗菌吸收层为方形，且顶端边缘处设置有倒角。
根据上述技术方案，所述抗菌经条和抗菌纬条均为含银敷料。
一种具有抗菌高吸收的医用敷料的制备方法，包括如下步骤：
S1、将纤维层和胶原层连接好，顶端放置好抗菌经条和抗菌纬条；
S2、将纤维层和胶原层倒扣在天然纱布顶端；
S3、将胶原层扣在胶原层顶端；
S4、在医用敷料中心贴敷有复合型敷料；
S5、在医用敷料正面中心处贴敷抗菌吸收层。
根据上述技术方案，所述纤维层为羧甲基纤维素钠纤维，所述羧甲基纤维素钠纤维制备方法如下：
A1、将已磨成粉末状的棉浆泊送到装有异丙醇的立式碱化机中,边搅拌边加入氢氧化钠溶液进行碱化；
A2、碱化后，用泵输送物料到立式醚化机中，加入氯乙酸的异丙醇溶液；
A3、醚化后到碱纤维素分子间进行醚化反应，制得的羧甲基。
根据上述技术方案，所述步骤A1中氢氧化钠溶液浓度为40%-50%，碱化温度为15-25摄氏度。
根据上述技术方案，所述复合型敷料包括利用海藻酸纤维、水溶性高分子、非织造纺织材料、聚氨酯泡沫和薄膜，通过各种形式的组合形成既有吸湿性也有保护性能的材料。
根据上述技术方案，所述抗菌吸收层为羧甲基纤维素钠纤维和藻酸盐配合而成；
所述藻酸盐制备步骤如下：
B1、将藻酸钠与藻酸钾放入在反应釜中，开始调和；
B2、接着加快搅拌速度，继续调和；
B3、引流出混合材料，去除气泡即可；
所述步骤B1      中搅拌速度为10-15r/min，且搅拌时间为10-15s；
所述步骤B2在搅拌速度为60-120r/min，且搅拌时间为50-70s。
根据上述技术方案，所述藻酸钠与藻酸钾比例为1：（0.9-1.3）。
与现有技术相比，本发明的有益效果：本发明结构科学合理，使用安全方便，通过天然纱布可以便于快速吸收创面渗出液，通过抗菌经条和抗菌纬条相互纺织，可以便于更一步的提高敷料的韧性，并且抗菌经条和抗菌纬条也可以保证医用敷料的进一步抗菌性，而纤维层采用羧甲基纤维素钠纤维和胶原层相互配合，可以便于促进皮肤组织合成代谢和细胞再生,提高皮肤局部温度和湿度,加速局部皮肤细胞的血液循环和新陈代谢，有利于皮肤细胞的更新换代,从而加速组织再生与修复，而藻酸盐敷料主要原料为甲基碳化钠纤维素和藻酸钙,主要特点是具有高吸湿性、成胶和止血性能，从而便于正常的肌肤痊愈。
附图说明
附图用来提供对本发明的进一步理解，并且构成说明书的一部分，与本发明的实施例一起用于解释本发明，并不构成对本发明的限制。
在附图中：
图1是本发明的结构示意图；
图2是本发明的抗菌经条和抗菌纬条安装结构示意图；
图3是本发明的剖视结构示意图；
图4是本发明的医疗敷料制备流程示意图；
图5是本发明的羧甲基纤维素钠纤维制备方法流程结构示意图；
图6是本发明的抗菌吸收层制备流程示意图；
图中标号：1、天然纱布；2、抗菌经条；3、抗菌纬条；4、纤维层；5、胶原层；6、倒三角；7、复合型敷料；8、抗菌吸收层。
具体实施方式
以下结合附图对本发明的优选实施例进行说明，应当理解，此处所描述的优选实施例仅用于说明和解释本发明，并不用于限定本发明。
实施例1：如图1-3所示，本发明提供技术方案，一种具有抗菌高吸收的医用敷料，包括天然纱布1，天然纱布1底端设置有抗菌经条2和抗菌纬条3，抗菌经条2和抗菌纬条3均为含银敷料，抗菌经条2和抗菌纬条3相互交叉纺织，抗菌经条2和抗菌纬条3的案子比例为4: 7，抗菌经条2和抗菌纬条3下方粘接有纤维层4，纤维层4底端设置有胶原层5，纤维层4和胶原层5之间设置有倒三角6，胶原层5底端设置有复合型敷料7，复合型敷料7中间嵌入有抗菌吸收层8，且抗菌吸收层8为方形，且顶端边缘处设置有倒角，。
本发明的工作原理及使用流程：使用中，通过天然纱布1可以便于快速吸收创面渗出液，通过抗菌经条2和抗菌纬条3相互纺织，可以便于更一步的提高敷料的韧性，并且抗菌经条2和抗菌纬条3也可以保证医用敷料的进一步抗菌性，而纤维层4采用羧甲基纤维素钠纤维和胶原层5相互配合，可以便于促进皮肤组织合成代谢和细胞再生,提高皮肤局部温度和湿度,加速局部皮肤细胞的血液循环和新陈代谢，有利于皮肤细胞的更新换代,从而加速组织再生与修复，而藻酸盐敷料主要原料为甲基碳化钠纤维素和藻酸钙,主要特点是具有高吸湿性、成胶和止血性能，从而便于正常的肌肤痊愈。
实施例2：如图1-3所示，本发明提供技术方案，一种具有抗菌高吸收的医用敷料，包括天然纱布1，天然纱布1底端设置有抗菌经条2和抗菌纬条3，抗菌经条2和抗菌纬条3均为含银敷料，抗菌经条2和抗菌纬条3相互交叉纺织，抗菌经条2和抗菌纬条3的案子比例为4:5，抗菌经条2和抗菌纬条3下方粘接有纤维层4，纤维层4底端设置有胶原层5，纤维层4和胶原层5之间设置有倒三角6，胶原层5底端设置有复合型敷料7，复合型敷料7中间嵌入有抗菌吸收层8，且抗菌吸收层8为方形，且顶端边缘处设置有倒角，。
本发明的工作原理及使用流程：使用中，通过天然纱布1可以便于快速吸收创面渗出液，通过抗菌经条2和抗菌纬条3相互纺织，可以便于更一步的提高敷料的韧性，并且抗菌经条2和抗菌纬条3也可以保证医用敷料的进一步抗菌性，而纤维层4采用羧甲基纤维素钠纤维和胶原层5相互配合，可以便于促进皮肤组织合成代谢和细胞再生,提高皮肤局部温度和湿度,加速局部皮肤细胞的血液循环和新陈代谢，有利于皮肤细胞的更新换代,从而加速组织再生与修复，而藻酸盐敷料主要原料为甲基碳化钠纤维素和藻酸钙,主要特点是具有高吸湿性、成胶和止血性能，从而便于正常的肌肤痊愈。
实施例3：如图1-3所示，本发明提供技术方案，一种具有抗菌高吸收的医用敷料，包括天然纱布1，天然纱布1底端设置有抗菌经条2和抗菌纬条3，抗菌经条2和抗菌纬条3均为含银敷料，抗菌经条2和抗菌纬条3相互交叉纺织，抗菌经条2和抗菌纬条3的案子比例为4:6，抗菌经条2和抗菌纬条3下方粘接有纤维层4，纤维层4底端设置有胶原层5，纤维层4和胶原层5之间设置有倒三角6，胶原层5底端设置有复合型敷料7，复合型敷料7中间嵌入有抗菌吸收层8，且抗菌吸收层8为方形，且顶端边缘处设置有倒角，。
本发明的工作原理及使用流程：使用中，通过天然纱布1可以便于快速吸收创面渗出液，通过抗菌经条2和抗菌纬条3相互纺织，可以便于更一步的提高敷料的韧性，并且抗菌经条2和抗菌纬条3也可以保证医用敷料的进一步抗菌性，而纤维层4采用羧甲基纤维素钠纤维和胶原层5相互配合，可以便于促进皮肤组织合成代谢和细胞再生,提高皮肤局部温度和湿度,加速局部皮肤细胞的血液循环和新陈代谢，有利于皮肤细胞的更新换代,从而加速组织再生与修复，而藻酸盐敷料主要原料为甲基碳化钠纤维素和藻酸钙,主要特点是具有高吸湿性、成胶和止血性能，从而便于正常的肌肤痊愈。
实施例4：如图4-6所示，本发明提供技术方案，一种具有抗菌高吸收的医用敷料的制备方法，包括如下步骤：
S1、将纤维层和胶原层连接好，顶端放置好抗菌经条和抗菌纬条；
S2、将纤维层和胶原层倒扣在天然纱布顶端；
S3、将胶原层扣在胶原层顶端；
S4、在医用敷料中心贴敷有复合型敷料；
S5、在医用敷料正面中心处贴敷抗菌吸收层。
根据上述技术方案，所述纤维层为羧甲基纤维素钠纤维，所述羧甲基纤维素钠纤维制备方法如下：
A1、将已磨成粉末状的棉浆泊送到装有异丙醇的立式碱化机中,边搅拌边加入氢氧化钠溶液进行碱化；
A2、碱化后，用泵输送物料到立式醚化机中，加入氯乙酸的异丙醇溶液；
A3、醚化后到碱纤维素分子间进行醚化反应，制得的羧甲基。
根据上述技术方案，所述步骤A1中氢氧化钠溶液浓度为50%，碱化温度为18摄氏度。
根据上述技术方案，所述复合型敷料包括利用海藻酸纤维、水溶性高分子、非织造纺织材料、聚氨酯泡沫和薄膜，通过各种形式的组合形成既有吸湿性也有保护性能的材料。
根据上述技术方案，所述抗菌吸收层为羧甲基纤维素钠纤维和藻酸盐配合而成；
所述藻酸盐制备步骤如下：
B1、将藻酸钠与藻酸钾放入在反应釜中，开始调和；
B2、接着加快搅拌速度，继续调和；
B3、引流出混合材料，去除气泡即可；
所述步骤B1      中搅拌速度为15r/min，且搅拌时间为10s；
所述步骤B2在搅拌速度为100r/min，且搅拌时间为60s。
根据上述技术方案，所述藻酸钠与藻酸钾比例为1：1。
实施例5：如图4-6所示，本发明提供技术方案，一种具有抗菌高吸收的医用敷料的制备方法，包括如下步骤：
S1、将纤维层和胶原层连接好，顶端放置好抗菌经条和抗菌纬条；
S2、将纤维层和胶原层倒扣在天然纱布顶端；
S3、将胶原层扣在胶原层顶端；
S4、在医用敷料中心贴敷有复合型敷料；
S5、在医用敷料正面中心处贴敷抗菌吸收层。
根据上述技术方案，所述纤维层为羧甲基纤维素钠纤维，所述羧甲基纤维素钠纤维制备方法如下：
A1、将已磨成粉末状的棉浆泊送到装有异丙醇的立式碱化机中,边搅拌边加入氢氧化钠溶液进行碱化；
A2、碱化后，用泵输送物料到立式醚化机中，加入氯乙酸的异丙醇溶液；
A3、醚化后到碱纤维素分子间进行醚化反应，制得的羧甲基。
根据上述技术方案，所述步骤A1中氢氧化钠溶液浓度为45%，碱化温度为19摄氏度。
根据上述技术方案，所述复合型敷料包括利用海藻酸纤维、水溶性高分子、非织造纺织材料、聚氨酯泡沫和薄膜，通过各种形式的组合形成既有吸湿性也有保护性能的材料。
根据上述技术方案，所述抗菌吸收层为羧甲基纤维素钠纤维和藻酸盐配合而成；
所述藻酸盐制备步骤如下：
B1、将藻酸钠与藻酸钾放入在反应釜中，开始调和；
B2、接着加快搅拌速度，继续调和；
B3、引流出混合材料，去除气泡即可；
所述步骤B1      中搅拌速度为12r/min，且搅拌时间为13s；
所述步骤B2在搅拌速度为7r/min，且搅拌时间为70s。
根据上述技术方案，所述藻酸钠与藻酸钾比例为1：0.9。
实施例6：如图4-6所示，本发明提供技术方案，一种具有抗菌高吸收的医用敷料的制备方法，包括如下步骤：
S1、将纤维层和胶原层连接好，顶端放置好抗菌经条和抗菌纬条；
S2、将纤维层和胶原层倒扣在天然纱布顶端；
S3、将胶原层扣在胶原层顶端；
S4、在医用敷料中心贴敷有复合型敷料；
S5、在医用敷料正面中心处贴敷抗菌吸收层。
根据上述技术方案，所述纤维层为羧甲基纤维素钠纤维，所述羧甲基纤维素钠纤维制备方法如下：
A1、将已磨成粉末状的棉浆泊送到装有异丙醇的立式碱化机中,边搅拌边加入氢氧化钠溶液进行碱化；
A2、碱化后，用泵输送物料到立式醚化机中，加入氯乙酸的异丙醇溶液；
A3、醚化后到碱纤维素分子间进行醚化反应，制得的羧甲基。
根据上述技术方案，所述步骤A1中氢氧化钠溶液浓度为40%，碱化温度为23摄氏度。
根据上述技术方案，所述复合型敷料包括利用海藻酸纤维、水溶性高分子、非织造纺织材料、聚氨酯泡沫和薄膜，通过各种形式的组合形成既有吸湿性也有保护性能的材料。
根据上述技术方案，所述抗菌吸收层为羧甲基纤维素钠纤维和藻酸盐配合而成；
所述藻酸盐制备步骤如下：
B1、将藻酸钠与藻酸钾放入在反应釜中，开始调和；
B2、接着加快搅拌速度，继续调和；
B3、引流出混合材料，去除气泡即可；
所述步骤B1      中搅拌速度为14r/min，且搅拌时间为12s；
所述步骤B2在搅拌速度为115r/min，且搅拌时间为55s。
根据上述技术方案，所述藻酸钠与藻酸钾比例为1：1.2。
通过实施例4-6制成的医用敷料进行对比，制成如下表格：
Figure dest_path_image002
通过对比，实施例1-4制成的医药敷料在抗菌率和吸收率上均有保障，但是实施例1的更加具备高效的抗菌率和吸收率，生产中可以更加适合推广。
最后应说明的是：以上所述仅为本发明的优选实例而已，并不用于限制本发明，尽管参照前述实施例对本发明进行了详细的说明，对于本领域的技术人员来说，其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (10)

  1. 一种具有抗菌高吸收的医用敷料，其特征在于：包括天然纱布（1），所述天然纱布（1）底端设置有抗菌经条（2）和抗菌纬条（3），所述抗菌经条（2）和抗菌纬条（3）相互交叉纺织，所述抗菌经条（2）和抗菌纬条（3）下方粘接有纤维层（4），所述纤维层（4）底端设置有胶原层（5），所述纤维层（4）和胶原层（5）之间设置有倒三角（6），所述胶原层（5）底端设置有复合型敷料（7），所述复合型敷料（7）中间嵌入有抗菌吸收层（8）。
  2. 根据权利要求1所述的一种具有抗菌高吸收的医用敷料，其特征在于，所述抗菌经条（2）和抗菌纬条（3）的案子比例为4:4-7。
  3. 根据权利要求1所述的一种具有抗菌高吸收的医用敷料，其特征在于，所述抗菌吸收层（8）为方形，且顶端边缘处设置有倒角。
  4. 根据权利要求1所述的一种具有抗菌高吸收的医用敷料及其制备方法，其特征在于，所述抗菌经条（2）和抗菌纬条（3）均为含银敷料。
  5. 根据权利要求1-4所述的一种具有抗菌高吸收的医用敷料的制备方法，其特征在于，包括如下步骤：
    S1、将纤维层和胶原层连接好，顶端放置好抗菌经条和抗菌纬条；
    S2、将纤维层和胶原层倒扣在天然纱布顶端；
    S3、将胶原层扣在胶原层顶端；
    S4、在医用敷料中心贴敷有复合型敷料；
    S5、在医用敷料正面中心处贴敷抗菌吸收层。
  6. 根据权利要求5所述的一种具有抗菌高吸收的医用敷料的制备方法，其特征在于，所述纤维层为羧甲基纤维素钠纤维，所述羧甲基纤维素钠纤维制备方法如下：
    A1、将已磨成粉末状的棉浆泊送到装有异丙醇的立式碱化机中,边搅拌边加入氢氧化钠溶液进行碱化；
    A2、碱化后，用泵输送物料到立式醚化机中，加入氯乙酸的异丙醇溶液；
    A3、醚化后到碱纤维素分子间进行醚化反应，制得的羧甲基。
  7. 根据权利要求6所述的一种具有抗菌高吸收的医用敷料的制备方法，其特征在于，所述步骤A1中氢氧化钠溶液浓度为40%-50%，碱化温度为15-25摄氏度。
  8. 根据权利要求5所述的一种具有抗菌高吸收的医用敷料的制备方法，其特征在于，所述复合型敷料包括利用海藻酸纤维、水溶性高分子、非织造纺织材料、聚氨酯泡沫和薄膜，通过各种形式的组合形成既有吸湿性也有保护性能的材料。
  9. 根据权利要求5所述的一种具有抗菌高吸收的医用敷料的制备方法，其特征在于，所述抗菌吸收层为羧甲基纤维素钠纤维和藻酸盐配合而成；
    所述藻酸盐制备步骤如下：
    B1、将藻酸钠与藻酸钾放入在反应釜中，开始调和；
    B2、接着加快搅拌速度，继续调和；
    B3、引流出混合材料，去除气泡即可；
    所述步骤B1 中搅拌速度为10-15r/min，且搅拌时间为10-15s；
    所述步骤B2在搅拌速度为60-120r/min，且搅拌时间为50-70s。
  10. 根据权利要求9所述的一种具有抗菌高吸收的医用敷料的制备方法，其特征在于，所述藻酸钠与藻酸钾比例为1：（0.9-1.3）。
PCT/CN2020/116843 2019-12-14 2020-09-22 一种具有抗菌高吸收的医用敷料及其制备方法 WO2021114811A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911287150.4A CN110917384A (zh) 2019-12-14 2019-12-14 一种具有抗菌高吸收的医用敷料及其制备方法
CN201911287150.4 2019-12-14

Publications (1)

Publication Number Publication Date
WO2021114811A1 true WO2021114811A1 (zh) 2021-06-17

Family

ID=69863582

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2020/116843 WO2021114811A1 (zh) 2019-12-14 2020-09-22 一种具有抗菌高吸收的医用敷料及其制备方法

Country Status (2)

Country Link
CN (1) CN110917384A (zh)
WO (1) WO2021114811A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110917384A (zh) * 2019-12-14 2020-03-27 浙江惠龙医疗科技股份有限公司 一种具有抗菌高吸收的医用敷料及其制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004100066A (ja) * 2002-09-06 2004-04-02 Du Pont Toray Co Ltd 耐熱性高機能糸製品の再利用方法
WO2007027849A2 (en) * 2005-08-31 2007-03-08 Board Of Regents, The University Of Texas System Multiribbon nanocellulose as a matrix for wound healing
CN102429770A (zh) * 2011-12-13 2012-05-02 晓健科技（大连）有限公司 新型医用高分子弹性绷带
CN205252142U (zh) * 2015-11-28 2016-05-25 湖北唯美医疗用品有限公司 一种外科手术消毒复合纱布
CN105997185A (zh) * 2016-06-21 2016-10-12 山东大学齐鲁医院 一种弹力止血吸收性敷料固定带
CN107399119A (zh) * 2017-08-11 2017-11-28 恒天嘉华非织造有限公司 一种石墨烯基纤维高端卫生材料及其制备工艺
CN110917384A (zh) * 2019-12-14 2020-03-27 浙江惠龙医疗科技股份有限公司 一种具有抗菌高吸收的医用敷料及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1721004A (zh) * 2004-07-15 2006-01-18 深圳市清华源兴生物医药科技有限公司 一种生物活性抗菌敷料
EP2035008B1 (en) * 2006-06-13 2011-11-23 Ethicon, Incorporated Compositions and methods for preventing or reducing postoperative ileus and gastric stasis in mammals
CN101450223A (zh) * 2007-11-30 2009-06-10 张博 一种基于壳聚糖、胶原蛋白和羧甲基纤维素钠的止血材料及其制备方法及应用
CN103007339B (zh) * 2012-12-06 2014-11-26 浙江医鼎医用敷料有限公司 生物粉体医用敷料及其制备方法
KR20160035129A (ko) * 2014-09-22 2016-03-31 주식회사 제네웰 항균물질의 서방용 창상 피복 조성물 및 창상피복재
CN105288706B (zh) * 2015-10-22 2019-02-05 李星华 一种妇产科用快速止血敷料及其制备方法
CN106492259A (zh) * 2016-11-03 2017-03-15 广东泰宝医疗科技股份有限公司 一种抗菌可溶性止血材料及其制备方法
CN107115555A (zh) * 2017-04-28 2017-09-01 广东泰宝医疗科技股份有限公司 一种高效吸液止血的复合型敷料及其制备方法
CN109009668A (zh) * 2018-08-27 2018-12-18 中鸿纳米纤维技术丹阳有限公司 一种纳米抑菌防感染自降解医用敷料
CN110227175A (zh) * 2019-05-13 2019-09-13 浙江惠龙医疗科技股份有限公司 一种具有抗菌、可促进伤口愈合的医用敷料及其制备方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004100066A (ja) * 2002-09-06 2004-04-02 Du Pont Toray Co Ltd 耐熱性高機能糸製品の再利用方法
WO2007027849A2 (en) * 2005-08-31 2007-03-08 Board Of Regents, The University Of Texas System Multiribbon nanocellulose as a matrix for wound healing
CN102429770A (zh) * 2011-12-13 2012-05-02 晓健科技（大连）有限公司 新型医用高分子弹性绷带
CN205252142U (zh) * 2015-11-28 2016-05-25 湖北唯美医疗用品有限公司 一种外科手术消毒复合纱布
CN105997185A (zh) * 2016-06-21 2016-10-12 山东大学齐鲁医院 一种弹力止血吸收性敷料固定带
CN107399119A (zh) * 2017-08-11 2017-11-28 恒天嘉华非织造有限公司 一种石墨烯基纤维高端卫生材料及其制备工艺
CN110917384A (zh) * 2019-12-14 2020-03-27 浙江惠龙医疗科技股份有限公司 一种具有抗菌高吸收的医用敷料及其制备方法

Also Published As

Publication number Publication date
CN110917384A (zh) 2020-03-27

Similar Documents

Publication Publication Date Title
CN111529748B (zh) 一种医用创面修复用复合敷料及其制备方法
CN104024498B (zh) 伤口敷料以及可用于伤口敷料中的线
CN104069537B (zh) 海藻酸钠-羧甲基纤维素钠-壳聚糖伤口敷料及其制备方法
US20100042034A1 (en) Wound care product, comprising textile ribbons with fibres having gel-forming properties, and fibres not having gel-forming properties
CN103536954B (zh) 一种交联海藻酸-细菌纤维素海绵及其制备方法
CN107469131A (zh) 一种海藻酸钙生物复合医用敷料及其制备方法
CN104491914A (zh) 一种多孔复合凝胶-纳米纤维透氧敷料及其制备方法
CN208193326U (zh) 一种防粘连促愈合复合敷料
CN103394155B (zh) 一次性便携式负压创面治疗系统
JPH06500028A (ja) 創傷被覆システム
CN87101823B (zh) 医用不粘敷料
CN103550817A (zh) 一种细菌纤维素/壳聚糖复合海绵敷料及其制备方法
CN107496972B (zh) 一种促烧伤创面愈合的防粘连湿性敷料及其制备方法
CN204655268U (zh) 一种藻酸盐医用敷料
CN106916399B (zh) 一种环境友好型多功能复合负压引流护创海绵及其制备方法
Wei The application of moist dressing in treating burn wound
CN104225668B (zh) 分阶段作用抗菌水凝胶敷料及其制备方法
WO2021114811A1 (zh) 一种具有抗菌高吸收的医用敷料及其制备方法
CN112402112A (zh) 一款具有超强吸血、锁血能力的卫生巾及其制备工艺
CN109077851B (zh) 一种高吸液纳米银抗菌保湿医用敷料及其制备方法
CN204158771U (zh) 一种细菌纤维素/壳聚糖复合海绵敷料
CN106474528A (zh) 一种可吸收抗菌医用敷料的制备方法
CN105536030A (zh) 一种止血促修复敷料芯片及其制备方法
CN107375996B (zh) 一种生物功能性敷料及其制备方法
CN110448714B (zh) 一种吸湿抑菌的壳聚糖/海藻酸钠交织型敷料及制备方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20898412

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20898412

Country of ref document: EP

Kind code of ref document: A1