WO2021109006A1

WO2021109006A1 - Medicinal liquid introduction head and penetration enhancement instrument

Info

Publication number: WO2021109006A1
Application number: PCT/CN2019/122809
Authority: WO
Inventors: 徐百
Original assignee: 苏州纳生微电子有限公司
Priority date: 2019-12-02
Filing date: 2019-12-03
Publication date: 2021-06-10
Also published as: CN211675890U

Abstract

Disclosed is a medicinal liquid introduction head, comprising: an introduction head body, wherein an end face of one end thereof forms a working face, and the introduction head body is integrally formed by means of injection molding; and a nanometer wafer, which comprises a base and microneedles arranged on the base, wherein the nanometer wafer is directly embedded into a mounting groove formed during injection molding of the introduction head body, and the microneedles on the nanometer wafer protrude out of the working face. The nanometer wafer in the medicinal liquid introduction head of the present utility model is directly embedded into the working face of the introduction head body, and avoids the combination of same with the introduction head body by means of an adhesive, thereby overcoming the defect occurring when the nanometer wafer is fixed by means of the adhesive, and facilitating the assembly and fixation of the nanometer wafer.

Description

Liquid drug introduction head and penetration enhancer

Technical field

The utility model relates to the technical field of transdermal drug delivery, in particular to a medicinal solution introduction head and a permeation promoting instrument.

Background technique

At present, in the field of transdermal drug delivery technology, nano-microneedles or nano-chips are being widely used. Among them, the nano-chip is a special tool for nano-infiltration enhancement developed based on the structure of human skin. It is carved from monocrystalline silicon through a nano-technology process. The surface of the nanochip is a series of microneedle arrays, which can open the outermost stratum corneum of the skin without damaging the dermis, greatly improving the penetration of drugs. The biocompatibility of monocrystalline silicon ensures the safety of nanocrystalline during use. The existing nano-microneedles or nano-chips are mainly fixed on the medicine storage container by means of glue. However, in the above-mentioned combination method, the glue is easy to spill out, thereby affecting the use. Therefore, it is necessary to propose further solutions to the above-mentioned problems.

Utility model content

The utility model aims to provide a medicinal liquid introduction head and a permeation enhancer to overcome the deficiencies in the prior art.

In order to solve the above technical problems, the technical solution of the present utility model is:

A medicinal liquid introduction head, which comprises:

The introduction head body, the end surface of one end thereof forms a working surface, and the introduction head body is integrally formed by injection molding;

A nanochip includes a base and a microneedle arranged on the base. The nanochip is directly embedded in the mounting groove formed during injection molding of the introduction head body, and the microneedles on the nanochip protrude from the base. The working surface settings are described.

As an improvement of the liquid medicine introducing head of the present invention, the inside of the introducing head body is hollow, and the working surface is provided with a liquid outlet hole communicating with the inside of the introducing head body.

As an improvement of the medicinal liquid introduction head of the present invention, there are a plurality of the liquid outlet holes, and the plurality of liquid outlet holes are distributed around the nano wafer.

As an improvement of the medicinal solution introduction head of the present invention, a protective cover is also installed at one end of the introduction head body, and the nano wafer and the working surface are accommodated in the space defined by the protective cover.

As an improvement of the liquid medicine introduction head of the present invention, an external thread is provided on the outer peripheral wall surface of one end of the introduction head body, and the protective cover is screwed to one end of the introduction head body through the external thread.

As an improvement of the medicinal solution introduction head of the present invention, the nano wafers are synchronously embedded into the working surface of the introduction head body during injection molding of the introduction head body.

As an improvement of the medicinal solution introduction head of the present invention, the nano wafer is embedded in the working surface of the introduction head body after injection molding of the introduction head body and before solidification.

As an improvement of the medicinal solution introduction head of the present invention, the introduction head body is also provided with a snap structure on the peripheral outer side wall, and the snap structure is a protrusion or depression provided on the outer side wall.

As an improvement of the liquid medicine introduction head of the present invention, the material of the introduction head body is a light-proof material.

A permeation enhancer, comprising: a housing, and the above-mentioned medicinal solution introduction head installed at the administration end of the housing.

Compared with the prior art, the beneficial effect of the present invention is that the nano-chip in the medicinal liquid introduction head of the present invention is directly embedded on the working surface of the introduction head body, which avoids the combination with the introduction head body by means of glue. , Overcoming the defects of glue fixation, and facilitating the assembly and fixation of nano-chips.

Description of the drawings

Fig. 1 is a three-dimensional schematic diagram of an embodiment of the medicinal liquid introduction head according to the utility model;

Figure 2 is a front view of an embodiment of the permeation enhancer according to the present invention.

Detailed ways

The following will clearly and completely describe the technical solutions in the embodiments of the present utility model with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, not all implementations. example. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the scope of protection of the present utility model.

As shown in FIG. 1, the present invention provides a medical liquid introduction head 100, which includes: an introduction head body 1 and a nano wafer 2.

The introduction head body 1 is hollow inside, so that the introduction head body 1 can be used as a storage container for liquid medicine. The end surface of one end of the introduction head body 1 forms a working surface. In order to facilitate the liquid discharge, correspondingly, a liquid discharge hole 11 communicating with the inside of the introduction head body 1 is provided on the working surface. Therefore, when the liquid medicine is stored in the introduction head body 1, the liquid medicine can flow out from the liquid outlet hole 11 to realize the medicine supply. In one embodiment, there are a plurality of the liquid outlet holes 11, and the plurality of liquid outlet holes 11 are distributed around the nanochip 2 so as to realize uniform supply of medicine.

In terms of the molding method, the introduction head body 1 is integrally molded by injection molding. In one embodiment, the introduction head body 1 is made of light-shielding materials, so as to prevent the medicinal solution stored in the introduction head body 1 from changing properties.

The nanochip 2 includes a base and microneedles arranged on the base.

Wherein, the nano-chip 2 is a special tool for nano-penetration enhancement developed according to the structure of human skin, and it is carved from monocrystalline silicon through nano-technology. The surface of the nanochip is a series of microneedles arranged in an array, which can open the outermost stratum corneum of the skin without damaging the dermis, greatly improving the penetration ability of drugs.

The nanochip 2 is directly embedded in the mounting groove formed during injection molding of the introduction head body 1, and the microneedles on the nanochip 2 protrude from the working surface. At this time, the surface of the nano wafer 2 in contact with the introduction head body 1 and the introduction head body 1 can infiltrate each other to be more securely combined. In this way, the combination with the introduction head body 1 by means of glue is avoided, the defects of fixing by means of glue are overcome, and the assembly and fixing of the nanochip 2 is facilitated.

In order to achieve mutual penetration between the nano wafer 2 and the introduction head body 1, the nano wafer 2 is synchronously embedded into the working surface of the introduction head body 1 during injection molding of the introduction head body 1. Alternatively, the nano wafer 2 may also be embedded in the working surface of the introduction head body 1 after injection molding of the introduction head body 1 and before curing. In the above-mentioned two assembly methods, since the introduction head body 1 is not completely cured and formed, and its own temperature is relatively high, the contact surfaces between the nano wafer 2 and the introduction head body 1 can penetrate and fuse with each other to achieve a firm combination.

In order to protect the nano wafer 2 and the working surface, and prevent the liquid stored in the introduction head body 1 from leaking, a protective cover 3 is also installed at one end of the introduction head body 1, and the nano wafer 2 and the working surface are accommodated in the In the space defined by the protective cover 3. At this time, the side of the protective cover 3 opposite to the working surface is pressed on the liquid outlet hole 11. Correspondingly, the side of the protective cover 3 opposite to the working surface is also provided with the protruding nano-chip 2 The housing cavity.

In order to realize the fixing of the protective cover 3, in one embodiment, an external thread is provided on the outer peripheral wall surface of one end of the introduction head body 1, and the protective cover 3 is screwed to the introduction head body 1 through the external threads. One end. In other embodiments, the introduction head body 1 can also be fitted on one end of the introduction head body 1 in a snap-fit manner.

As shown in FIG. 2, based on the above-mentioned liquid medicine introduction head 100, the present invention also provides a permeation enhancer 200 using the liquid medicine introduction head 100. Specifically, the permeation enhancer 200 includes a housing 201, and the above-mentioned medicinal solution introduction head 100 installed on the drug delivery end of the housing 201.

In order to facilitate the connection and fixation between the housing 201 and the medicinal solution introduction head 100, the introduction head body 1 is also provided with an engaging structure 12 on the peripheral outer side wall, and the engaging structure 12 is arranged on the outer side wall. The bulge or depression. Wherein, when the engaging structure 12 is a protrusion provided on the outer side wall, a corresponding position in the inner cavity of the drug delivery end of the housing 201 is provided with a card slot matching the protrusion; When the engaging structure 12 is a recess provided on the outer side wall, a corresponding position in the inner cavity of the drug delivery end of the housing 201 is provided with a buckle matching the protrusion. In this way, when the liquid medicine introduction head 100 is used up, it can be removed and discarded, and the liquid medicine introduction head 100 can be replaced with a new one, which is convenient for the user to use.

To sum up, the nano-chips in the medicinal solution introduction head of the present invention are directly embedded on the working surface of the introduction head body, which avoids the combination of the introduction head body by means of glue, and overcomes the defects of the fixing method of glue. , Which facilitates the assembly and fixation of nano wafers.

For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic characteristics of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description, and therefore it is intended to fall on the rights. All the changes in the meaning and scope of the required equivalent elements are included in the present invention. Any reference signs in the claims should not be regarded as limiting the claims involved.

In addition, it should be understood that although this specification is described in accordance with the implementation manners, not each implementation manner only includes an independent technical solution. This narration in the specification is only for the sake of clarity, and those skilled in the art should regard the specification as a whole The technical solutions in the various embodiments can also be appropriately combined to form other implementations that can be understood by those skilled in the art.

Claims

A liquid medicine introducing head, characterized in that the liquid medicine introducing head comprises:

The introduction head body, the end surface of one end thereof forms a working surface, and the introduction head body is integrally formed by injection molding;

A nanochip includes a base and a microneedle arranged on the base. The nanochip is directly embedded in the mounting groove formed during injection molding of the introduction head body, and the microneedles on the nanochip protrude from the base. The working surface settings are described.
The liquid medicine introducing head according to claim 1, wherein the inside of the introducing head body is hollow, and the working surface is provided with a liquid outlet hole communicating with the inside of the introducing head body.
The liquid medicine introduction head according to claim 2, wherein the liquid outlet holes are multiple, and the multiple liquid outlet holes are distributed around the nano wafer.
The medicinal solution introduction head according to any one of claims 1 to 3, wherein a protective cover is installed at one end of the introduction head body, and the nanochip and the working surface are accommodated in the space defined by the protective cover .
The medicinal solution introduction head according to claim 4, wherein the outer peripheral wall surface of one end of the introduction head body is provided with an external thread, and the protective cover is screwed to one end of the introduction head body through the external thread .
The medical solution introduction head according to claim 1, wherein the nano wafer is synchronously embedded into the working surface of the introduction head body during injection molding of the introduction head body.
The liquid medicine introduction head according to claim 1, wherein the nano wafer is embedded in the working surface of the introduction head body after injection molding of the introduction head body and before solidification.
The medicinal solution introduction head according to claim 1, wherein an engaging structure is further provided on the peripheral outer side wall of the introduction head body, and the engaging structure is a protrusion provided on the outer side wall. Or recessed.
The medical solution introduction head according to claim 1, wherein the material of the introduction head body is a light-proof material.
A permeation enhancer, characterized in that, the permeation enhancer comprises: a housing, and the medicinal solution introduction head according to any one of claims 1-9 installed on the drug delivery end of the housing.