CN110368576A - Quantitative liquid feedway - Google Patents

Quantitative liquid feedway Download PDF

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Publication number
CN110368576A
CN110368576A CN201910784796.7A CN201910784796A CN110368576A CN 110368576 A CN110368576 A CN 110368576A CN 201910784796 A CN201910784796 A CN 201910784796A CN 110368576 A CN110368576 A CN 110368576A
Authority
CN
China
Prior art keywords
medical fluid
head
quantitative liquid
shell
imports
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910784796.7A
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Chinese (zh)
Inventor
徐百
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Nasheng Microelectronics Co Ltd
Original Assignee
Suzhou Nasheng Microelectronics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Nasheng Microelectronics Co Ltd filed Critical Suzhou Nasheng Microelectronics Co Ltd
Priority to CN201910784796.7A priority Critical patent/CN110368576A/en
Publication of CN110368576A publication Critical patent/CN110368576A/en
Priority to PCT/CN2019/122805 priority patent/WO2021036075A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Abstract

The present invention provides a kind of quantitative liquid feedway comprising: shell, the medical fluid for being installed on described shell one end import head and are installed on the transmission mechanism, power mechanism and power module of the enclosure interior.Quantitative liquid feedway of the invention is optimized by importing the vibration frequency of the structure etc. of head to medical fluid, can be realized the dosed administration under vibrational state, is conducive to the absorptivity for improving medical fluid.In addition, medical fluid, which imports head, to be used in combination as bottle stopper or bottle cover with medicinal liquid bottle, cutaneous penetration can be realized, with easy to use, and the advantages of cost is relatively low.

Description

Quantitative liquid feedway
Technical field
The present invention relates to cutaneous penetration technical field more particularly to a kind of quantitative liquid feedways.
Background technique
Currently, nanometer chip is just widely used in cutaneous penetration technical field.Wherein nanometer chip is according to human body skin The nanometer of skin mechanical development promotees to seep specific purpose tool, it is to be carved by monocrystalline silicon by nanotechnology technique.Nanometer chip Surface is a series of microneedle arrays, they can open the outmost cuticula of skin, while will not injure skin corium, is mentioned significantly The penetrating power of high nutrient.The bio-compatibility of monocrystalline silicon in turn ensures the safety of nano-crystal in use.Nanometer chip It is a kind of micropin that skin pipeline is opened by nanotechnology, syringe needle has been covered with close above similar to one piece slight of chip square It is close, carefully arrive the small needle that can't see, this small cube is pressed on the skin, drug can be allowed to enter epidermis, and people does not almost have It feels.
Currently, nanometer chip mainly has two class of solid microneedles and hollow microneedles.For solid microneedles administration mode, mainly all Two steps are divided into, medical fluid is first applied and punches again, or first punch coating again.If patent announcement number is CN103079634B, it discloses A kind of built-in non-language being integrated into giver instructs equipment, is coated before perforation or after perforation by the way of Medicament.But in the whole process, since transdermal and administration is carried out separately, the infiltration of drug can be influenced to a certain extent It absorbs, this plays such product in service efficiency and drug effect and ideal effect is not achieved.
It is more used in the prior art for empty micropin, if patent announcement number is CN102497909B, denomination of invention For the patent of invention of " hollow microneedle arrays ", it discloses a kind of for conveying the hollow microneedles of liquid.But it is this hollow micro- The manufacturing cost of needle is relatively high, and yield is relatively low, and qualification rate is relatively low.More importantly because administering position comparison sheet is shallow, Often there is the case where leakage after injection
Therefore, the present inventor needs to conceive a kind of new technology to improve its problem.
Summary of the invention
The present invention is intended to provide a kind of quantitative liquid feedway, to overcome the deficiencies in the prior art.
In order to solve the above technical problems, the technical scheme is that
A kind of quantitative liquid feedway comprising: shell, the medical fluid for being installed on described shell one end import head and peace Transmission mechanism, power mechanism and power module loaded on the enclosure interior;
The transmission mechanism generates linear movement, the power mechanism and the power supply under the driving of the power mechanism Module connection, the medical fluid imports head and extend into the shell from described shell one end, and fills in or be set in positioned at institute The bottleneck of the medicinal liquid bottle in shell is stated, the medicinal liquid bottle is connected with the transmission mechanism;
It includes: that medical fluid imports head ontology and is set on medical fluid importing head ontology end face that the medical fluid, which imports head, Chip, the medical fluid import offered on the end face of the outlet end of head ontology imported with the medical fluid be connected inside head go out liquid Hole, the chip are set on the end face of the outlet end, and the chip has the lattice structure arranged in the form of an array.
Preferably, the transmission mechanism includes energy-storage units and vibration unit, wherein the energy-storage units are arranged described Between vibration unit and the medicinal liquid bottle, the vibration unit activates under the driving of the power mechanism and exerts a force to institute Energy-storage units are stated, the energy-storage units are connected with the medicinal liquid bottle.
Preferably, the energy-storage units are spring, and the vibration unit is hertz oscilltor.
Preferably, the power mechanism is motor.
Preferably, the medical fluid importing head ontology is open at one end, another to bring out liquid, and the medical fluid imports the opening of head ontology End forms the installation end matched with the bottleneck, and sealing knot is provided on the periphery wall surface or inner peripheral wall of the installation end Structure.
Preferably, the sealing structure be set to it is O-shaped close on the periphery wall surface or inner peripheral wall of the installation end Seal.
Preferably, in the mounting groove on end face that the chip is installed on the outlet end in a manner of chimeric.
Preferably, the fluid hole is at least one, at least one fluid hole is opened in the side of the end face of the outlet end Edge position, the chip are set to the middle position of the end face of the outlet end.
Preferably, it is plastic part that the medical fluid, which imports head ontology, and the medical fluid imports head ontology integrated injection molding.
Preferably, the medicinal liquid bottle of the inside of the shell and the medical fluid being matched therewith import head and have axially and radially Movement travel.
Compared with prior art, the beneficial effects of the present invention are: quantitative liquid feedway of the invention passes through to medical fluid The vibration frequency for importing structure of head etc. optimizes, and can be realized the dosed administration under vibrational state, is conducive to mention The absorptivity of high medical fluid.In addition, medical fluid, which imports head, to be used in combination as bottle stopper or bottle cover with medicinal liquid bottle, can be realized Skin administration, with easy to use, and the advantages of cost is relatively low.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this The some embodiments recorded in invention, for those of ordinary skill in the art, without creative efforts, It is also possible to obtain other drawings based on these drawings.
The floor map that Fig. 1 is quantitative liquid feedway of the invention when being gun-shaped;
The floor map that Fig. 2 is quantitative liquid feedway of the invention when being pen shape;
Fig. 3 is the main view that Fig. 1 Chinese medicine liquid imports one specific embodiment when head is used as bottle stopper;
Fig. 4 is the top view that Fig. 3 Chinese medicine liquid imports head;
Fig. 5 is the main view that Fig. 1 Chinese medicine liquid imports one specific embodiment when head is used as bottle cover;
Fig. 6 is liquid outlet quantity-time graph of quantitative liquid feedway of the invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
As shown in Figure 1, 2, the present invention provides a kind of quantitative liquid feedway comprising: the quantitative liquid supply dress Set include: shell 20, the medical fluid that is installed on described 20 one end of shell imports head 10 and the biography that is installed on inside the shell 20 Motivation structure, power mechanism 23 and power module.
The shell 20 forms quantitative liquid feedway main structure of the invention, can be a pen shape, can also be with For a gun-shaped.When the shell 20 is pen shape, the shell 20 is substantially in a cylindrical cavity.When the shell 20 is gun-shaped When, there is the shell 20 handle sturcture 201 to hold wherein the handle sturcture 201 matches with manpower size convenient for manpower It holds.
20 inner hollow of the shell setting, the transmission mechanism, power mechanism 23 and power module are installed on the shell In body 20.The transmission mechanism generates linear movement under the driving of the power mechanism 23, the power mechanism 23 with it is described Power module connection.Meanwhile the medicinal liquid bottle in the shell 20 is connected with the transmission mechanism.
Specifically, in order to realize the linear movement of the transmission mechanism, the transmission mechanism includes energy-storage units 21 and vibration Moving cell 22, wherein the energy-storage units 21 are arranged between the vibration unit 22 and the medicinal liquid bottle, the vibration unit 22 activate under the driving of the power mechanism 23 and exert a force to the energy-storage units 21, the energy-storage units 21 with it is described Medicinal liquid bottle is connected.To which medicinal liquid bottle is driven by the vibration unit 22 vibrates drug along linear direction.
In a preferred embodiment, the energy-storage units 21 are spring, and the telescopic direction of the spring is upper at this time State linear direction.In order to realize that medicinal liquid bottle is connected with transmission mechanism, the spring pocket is loaded on the end of medicinal liquid bottle.The vibration Unit 22 is hertz oscilltor.The power module can be rechargeable, or non-rechargeable.The power mechanism 23 be motor.
As shown in Fig. 3,4,5, the medical fluid imports head 10 and can be used in combination as bottle stopper or bottle cover with medicinal liquid bottle, energy Cutaneous penetration is enough realized, with easy to use, and the advantages of cost is relatively low.
The medical fluid imports head 10 for realizing drug under medicinal liquid bottle vibrational state, protrudes into from described 20 one end of shell Into the shell 20, and fill in or be set in the bottleneck of the medicinal liquid bottle in the shell 20.
Specifically, it includes: that medical fluid imports head ontology 1 and is set to the medical fluid importing head sheet that the medical fluid, which imports head 10, Chip 2 on 1 end face of body.Preferably, it is plastic part that the medical fluid, which imports head ontology 1, and the medical fluid imports 1 one note of head ontology It is moulded into type.
Wherein, the medical fluid importing head ontology 1 is open at one end, another to bring out liquid.The medical fluid imports the opening of head ontology 1 End forms installation end 11, in use, the installation end 11 that medical fluid imports head can be inserted into medicinal liquid bottle.Meanwhile in order to enable medicine Liquid, which imports, has good leakproofness, to prevent leak-stopping liquid, the periphery wall surface or interior of the installation end 11 between head and medicinal liquid bottle Sealing structure 12 is provided in peripheral wall surfaces.
In one embodiment, the sealing structure 12 be set to it is O-shaped on the periphery wall surface of the installation end 11 Sealing ring, correspondingly, offering the mounting groove of O-ring seal on the periphery wall surface or inner peripheral wall of the installation end 11.It is excellent Selection of land, the O-ring seal are two, and two O-ring seals form double sealing structure 12.
In addition, it is additionally provided with limited step 14 on the periphery wall surface of the outlet end 13 of the medical fluid importing head ontology 1, the limit Position step 14 can import head to the medical fluid being installed on medicinal liquid bottle and carry out axial limiting.
It offers to import inside head with the medical fluid on the end face of the outlet end 13 of the medical fluid importing head ontology 1 and be connected Fluid hole 131, so that the medical fluid in medicinal liquid bottle can be flowed out from fluid hole 131 when medical fluid imports head and is inserted on medicinal liquid bottle. In one embodiment, the fluid hole 131 is at least one, at least one fluid hole 131 is opened in the outlet end 13 End face marginal position, the chip 2 is set to the middle position of the end face of the outlet end 13.Preferably, the liquid out The quantity in hole 131 is four.
The chip 2 is used for open the outmost cuticula of skin, while will not injure skin corium, to improve drug Penetrating power.The chip 2 is set on the end face of the outlet end 13, and the chip 2 has the point arranged in the form of an array Battle array structure.Preferably, the lattice structure is having a size of nanoscale micropin.In one embodiment, the chip 2 is with embedding Conjunction mode is installed in the mounting groove on the end face of the outlet end 13, while being also filled between the chip 2 and mounting groove Viscose glue.
In order to adjust the position that the medical fluid imports head 10, the medicinal liquid bottle of the inside of the shell 20 and it is matched therewith Medical fluid imports head with movement travel axially and radially.In this way, the medical fluid, which imports head 10, to carry out axial direction with respect to shell 20 With radial adjusting, the i.e. three-dimensional regulation of XYZ in space.Wherein, axial adjusting can be by the installation site of change medicinal liquid bottle It realizes, radial adjusting can import setting cushion block between head and shell 20 in medical fluid by setting and realize.
In addition, being also found surprisingly that, the liquid outlet quantity of fluid Supplying apparatus of the invention keeps phase with the variation of vibration frequency Also have the advantages that liquid outlet quantity is constant to constant therefore of the invention fluid Supplying apparatus.Because according to habitual thinking, liquid out Amount should increase with the increase of vibration frequency.However, it is possible to import structure of head etc. due in the present invention for medical fluid and carry out Optimization design thereby reduces the influence of the variation of vibration frequency, so that liquid outlet quantity keeps relative constant, and then is conducive to skin Absorption for medical fluid reduces waste.
Above-mentioned unexpected technical effect is verified below, the medical fluid of fluid Supplying apparatus of the invention is imported The medical fluid of 7.18g is packed into head.By the way that the vibration frequency of basic, normal, high three gears is arranged, going out under different vibration frequencies is observed Liquid measure situation.As a result as shown in fig. 6, it can be seen that the liquid outlet quantity of liquid reaches unanimity under basic, normal, high three gears.
In conclusion the structure etc. that quantitative liquid feedway of the invention imports head to medical fluid optimizes, together When, medical fluid imports head and can be used in combination as bottle stopper or bottle cover with medicinal liquid bottle, can be realized cutaneous penetration, has and uses The advantages of convenient, and cost is relatively low.In addition, quantitative liquid supply dress of the invention can also realize under vibrational state quantify to Medicine is conducive to the absorptivity for improving medical fluid.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims Variation is included within the present invention.Any reference signs in the claims should not be construed as limiting the involved claims.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art The other embodiments being understood that.

Claims (10)

1. a kind of quantitative liquid feedway, which is characterized in that the quantitative liquid feedway includes: shell, is installed on institute The medical fluid for stating shell one end imports head and is installed on the transmission mechanism, power mechanism and power module of the enclosure interior;
The transmission mechanism generates linear movement, the power mechanism and the power module under the driving of the power mechanism Connection, the medical fluid imports head and extend into the shell from described shell one end, and fills in or be set in positioned at the shell The bottleneck of medicinal liquid bottle in body, the medicinal liquid bottle are connected with the transmission mechanism;
It includes: that medical fluid imports head ontology and is set to the core that the medical fluid imports on head ontology end face that the medical fluid, which imports head, Piece, the medical fluid import offered on the end face of the outlet end of head ontology imported with the medical fluid be connected inside head go out liquid Hole, the chip are set on the end face of the outlet end, and the chip has the lattice structure arranged in the form of an array.
2. quantitative liquid feedway according to claim 1, which is characterized in that the transmission mechanism includes energy-storage units And vibration unit, wherein the energy-storage units are arranged between the vibration unit and the medicinal liquid bottle, the vibration unit exists The energy-storage units are activated and exerted a force under the driving of the power mechanism, and the energy-storage units are connected with the medicinal liquid bottle It connects.
3. quantitative liquid feedway according to claim 2, which is characterized in that the energy-storage units are spring, described Vibration unit is hertz oscilltor.
4. quantitative liquid feedway according to claim 1, which is characterized in that the power mechanism is motor.
5. quantitative liquid feedway according to claim 1, which is characterized in that the medical fluid imports head ontology one end and opens Mouthful, another to bring out liquid, the open end that the medical fluid imports head ontology forms the installation end matched with the bottleneck, the installation Sealing structure is provided on the periphery wall surface or inner peripheral wall at end.
6. quantitative liquid feedway according to claim 5, which is characterized in that the sealing structure is described to be set to O-ring seal on the periphery wall surface or inner peripheral wall of installation end.
7. quantitative liquid feedway according to claim 1, which is characterized in that the chip is installed in a manner of chimeric In mounting groove on the end face of the outlet end.
8. quantitative liquid feedway according to claim 1, which is characterized in that the fluid hole is at least one, until A few fluid hole is opened in the marginal position of the end face of the outlet end, and the chip is set to the end face of the outlet end Middle position.
9. quantitative liquid feedway according to claim 1, which is characterized in that it is plastics that the medical fluid, which imports head ontology, Part, the medical fluid import head ontology integrated injection molding.
10. quantitative liquid feedway according to claim 1, which is characterized in that the medicinal liquid bottle of the inside of the shell And the medical fluid being matched therewith imports head with movement travel axially and radially.
CN201910784796.7A 2019-08-23 2019-08-23 Quantitative liquid feedway Pending CN110368576A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201910784796.7A CN110368576A (en) 2019-08-23 2019-08-23 Quantitative liquid feedway
PCT/CN2019/122805 WO2021036075A1 (en) 2019-08-23 2019-12-03 Fixed-quantity liquid supply method

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Application Number Priority Date Filing Date Title
CN201910784796.7A CN110368576A (en) 2019-08-23 2019-08-23 Quantitative liquid feedway

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Publication Number Publication Date
CN110368576A true CN110368576A (en) 2019-10-25

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WO (1) WO2021036075A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020114403A1 (en) * 2018-12-06 2020-06-11 苏州纳通生物纳米技术有限公司 Medicinal liquid introduction head and drug delivery device
WO2021036076A1 (en) * 2019-08-23 2021-03-04 苏州纳生微电子有限公司 Quantitative liquid supply device
WO2021036075A1 (en) * 2019-08-23 2021-03-04 苏州纳生微电子有限公司 Fixed-quantity liquid supply method
WO2021109006A1 (en) * 2019-12-02 2021-06-10 苏州纳生微电子有限公司 Medicinal liquid introduction head and penetration enhancement instrument
CN114748778A (en) * 2021-01-11 2022-07-15 苏州纳生微电子有限公司 Transmission structure, liquid feeding device applying transmission structure and using method of liquid feeding device

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KR100917429B1 (en) * 2008-12-15 2009-09-14 (주)디티에스랩 The skin stimulus system
WO2013166162A1 (en) * 2012-05-01 2013-11-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
CN203355124U (en) * 2013-06-15 2013-12-25 陈彦彪 Micro-needle wafer carrier plate
EP3037124A1 (en) * 2014-12-22 2016-06-29 Universite Libre De Bruxelles Drug delivery device with microneedles
CN104689466B (en) * 2015-03-31 2018-02-16 苏州纳通生物纳米技术有限公司 A kind of channel-style nanometer beauty instrument and its application method
CN107913460B (en) * 2016-10-10 2021-06-22 苏州纳通生物纳米技术有限公司 Liquid quantitative conveying system
CN107913459A (en) * 2016-10-10 2018-04-17 苏州纳通生物纳米技术有限公司 A kind of liquid quantitative conveying device
CN208865020U (en) * 2018-05-30 2019-05-17 赖福平 A kind of storage delivery device of pharmaceutical gel
CN110368576A (en) * 2019-08-23 2019-10-25 苏州纳生微电子有限公司 Quantitative liquid feedway

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020114403A1 (en) * 2018-12-06 2020-06-11 苏州纳通生物纳米技术有限公司 Medicinal liquid introduction head and drug delivery device
WO2021036076A1 (en) * 2019-08-23 2021-03-04 苏州纳生微电子有限公司 Quantitative liquid supply device
WO2021036075A1 (en) * 2019-08-23 2021-03-04 苏州纳生微电子有限公司 Fixed-quantity liquid supply method
WO2021109006A1 (en) * 2019-12-02 2021-06-10 苏州纳生微电子有限公司 Medicinal liquid introduction head and penetration enhancement instrument
CN114748778A (en) * 2021-01-11 2022-07-15 苏州纳生微电子有限公司 Transmission structure, liquid feeding device applying transmission structure and using method of liquid feeding device

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