CN107913459A - A kind of liquid quantitative conveying device - Google Patents
A kind of liquid quantitative conveying device Download PDFInfo
- Publication number
- CN107913459A CN107913459A CN201610883873.0A CN201610883873A CN107913459A CN 107913459 A CN107913459 A CN 107913459A CN 201610883873 A CN201610883873 A CN 201610883873A CN 107913459 A CN107913459 A CN 107913459A
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- CN
- China
- Prior art keywords
- liquid
- conveying device
- quantitative conveying
- actuating unit
- outlet end
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Abstract
The invention discloses a kind of liquid quantitative conveying device, including a housing and a cavity head, housing is externally provided with a handle sturcture, control mechanism and a connecting end surface, it is built-in with transmission mechanism, actuating unit and power module, the transmission mechanism produces linear movement under the driving of the actuating unit, the actuating unit is connected with the power module, and the control mechanism controls the actuating unit action；Cavity head include outlet end and with can openend liquid reservoir, the outlet end upper surface, which is equipped with, to be used to only penetrate the micro device of keratoderma；The liquid reservoir is built-in with liquid, its can openend be connected with the outlet end, its other end is connected with the connecting end surface of the housing, and is connected under pressure with the transmission mechanism.The present invention can realize synchronous administration, and can significantly improve operational efficiency, reduce production manufacturing cost.
Description
Technical field
The present invention relates to cutaneous penetration technical field, particularly relates to a kind of liquid quantitative conveying device.
Background technology
Just it is widely used in cutaneous penetration technical field, nanometer micropin or nanometer chip at present.Wherein nanometer chip is
Promoted to ooze specific purpose tool according to the nanometer of human skin mechanical development, it is formed by nanometer technology technique engraving by monocrystalline silicon.
The surface of nanometer chip is a series of microneedle arrays, they can open the outmost cuticula of skin, while will not be injured true
Cortex, greatly improves the penetrating power of nutrient.The bio-compatibility of monocrystalline silicon in turn ensure that the safety of nano-crystal in use
Property.Nanometer micropin is a kind of micropin that skin pipeline is opened by nanometer technology, syringe needle similar to one piece slight of chip square, on
Face be covered with it is close, carefully arrive the small pin that can't see, by this blockage press on the skin, with regard to medicine can be allowed to enter epidermis,
And people is almost without sensation.
Nanometer micropin mainly has two class of solid microneedles and hollow microneedles at present.For solid microneedles administering mode, mainly all
Two steps are divided into, liquid is first applied and punches again, or first punch coating again.If patent announcement number is CN103079634B, it discloses
A kind of built-in non-language for being integrated into giver instructs equipment, its be by the way of perforation before or perforation after coat
Medicament.But in whole process, since transdermal and administration is carried out separately, the infiltration of medicine can be influenced to a certain extent
Absorb, this causes such product is played in service efficiency and drug effect not reach preferable effect.
For empty micropin, what is used in the prior art is more, if patent announcement number is CN102497909B, denomination of invention
For the patent of invention of " hollow microneedle arrays ", it discloses a kind of hollow microneedles for being used to convey liquid.It is but this hollow micro-
The manufacture cost of pin is higher, and productivity ratio is relatively low, and qualification rate is relatively low.What is more important because administering position comparison sheet it is shallow,
Often there is the situation of leakage after injection, dosage can not be accurately controlled.
Therefore, there is an urgent need for conceive a kind of new technology to improve its problem by the present inventor.
The content of the invention
The present invention is intended to provide a kind of liquid quantitative conveying device, it can realize synchronous administration, and significantly improve to
Drug effect rate, reduces production manufacturing cost.
In order to solve the above technical problems, the technical scheme is that：
A kind of liquid quantitative conveying device, including：
One housing, it is externally provided with a handle sturcture, control mechanism and a connecting end surface, it is built-in with transmission mechanism, power
Mechanism and power module, the transmission mechanism produce linear movement under the driving of the actuating unit, the actuating unit with
The power module connection, the control mechanism control the actuating unit action；
One cavity head, it include outlet end and with can openend liquid reservoir, the outlet end upper surface be equipped with use
In the micro device for only penetrating keratoderma；The liquid reservoir is built-in with liquid, it can openend and outlet end company
Connect, its other end is connected with the connecting end surface of the housing, and is connected under pressure with the transmission mechanism.
Preferably, the outlet end is equipped with a plastic part, and prefabricated fluid hole is equipped with the plastic part and is connected therewith
Logical fluid groove, the micro device are adhered to the surface of the plastic part.
Preferably, the transmission mechanism includes energy-storage units and vibration unit, wherein the energy-storage units be arranged on it is described
Between vibration unit and the cavity head, the vibration unit activates under the driving of the actuating unit and along perpendicular to institute
The direction for stating outlet end exerts a force to the energy-storage units, and the energy-storage units connect with the liquid reservoir in the cavity head
Connect, and by activating with automatically open up it is described can openend so that it is described can openend connected with the prefabricated fluid hole, promote
Liquid sequentially pass through it is described can openend, the prefabricated fluid hole and the micro device.
Preferably, the micro device is nanometer solid microneedles or nanometer solid array of microneedles, it is pierced into skin keratin
The length of layer is between 4 microns to 2000 microns.
Preferably, the liquid reservoir includes the first bank and the second bank, and the first bank front end goes out equipped with described in
Liquid end, second bank are connected with first bank.
Preferably, the centre on the plastic part is equipped with the prefabricated fluid hole, and the fluid groove is in cross
Or annular and connected with the prefabricated fluid hole.
Preferably, the control mechanism is one or more control button.
Preferably, a charging interface is additionally provided with the housing.
Preferably, the actuating unit is motor.
Preferably, the energy-storage units are spring, and the vibration unit is hertz oscilltor.
Using above-mentioned technical proposal, the present invention includes at least following beneficial effect：
Liquid quantitative conveying device of the present invention, is combined together medicine and administration device, structure is simpler
With it is reasonable.And great change is carried out to administering mode, there is provided a kind of between traditional injection and traditional transdermal to give
A kind of novel medicine feeding method between medicine, i.e., with the mode of similar injection, liquid quality by liquid reservoir, be delivered to skin table
Epidermis face, spreads through epidermis, into blood circulation of human body, since the mode being synchronously administered is set, i.e., is touched in nanometer solid microneedles
Go out liquid while skin, use is more convenient.What is more important, Medicated Permeation and absorption are more preferable.It is solid micro- additionally by nanometer
Pin or nanometer solid array of microneedles, open cuticula, liquid are slowly controlled, do not have the generation of the phenomenon of leakage, while can be with
Dosage is accurately controlled, reduces manufacture cost.
Brief description of the drawings
Fig. 1 is the structure diagram of liquid quantitative conveying device of the present invention；
Fig. 2 is the top view of liquid quantitative conveying device of the present invention；
Fig. 3 is the structure diagram of outlet end of the present invention；
Fig. 4 changes over time figure for permeability in experiment two.
Wherein：1. housing, 11. transmission mechanisms, 12. actuating units, 2. outlet ends, 21. plastic parts, 22. prefabricated fluid holes,
23. fluid groove, 3. liquid reservoirs, 31. first banks, 32. second banks, 4. handle sturctures, 5. control mechanisms.
Embodiment
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other without making creative work
Embodiment, belongs to the scope of protection of the invention.
As shown in Figure 1 to Figure 3, for meet the present invention a kind of liquid quantitative conveying device, including：
One housing 1, it is externally provided with a handle sturcture 4,5 and one connecting end surface of control mechanism, its be built-in with transmission mechanism 11,
Actuating unit 12 and power module (chargeable or not chargeable), the transmission mechanism 11 is under the driving of the actuating unit 12
Linear movement is produced, the actuating unit 12 is connected with the power module, and the control mechanism 5 controls the actuating unit 12
Action；Wherein described handle sturcture 4 matches with human hand size, is gripped easy to human hand；The control mechanism 5 is used for control device
Whether work；The connecting end surface is used for following cavity capitiforms into being connected.
One cavity head, it include outlet end 2 and with can openend liquid reservoir 3,2 upper surface of outlet end is equipped with
For only penetrating the micro device of keratoderma；The liquid reservoir 3 is built-in with liquid, it can openend and the outlet end
2 connections, its other end is connected with the connecting end surface of the housing 1, and is connected under pressure with the transmission mechanism 11.I.e.
Only when there is pressure to act on cavity head, the cavity head can be just connected with the transmission mechanism 11.And in the transmission
Liquid is imported into human skin by the outlet end 2 under the action of mechanism 11.
Preferably, the outlet end 2 is equipped with a plastic part 21, and prefabricated 22 He of fluid hole is equipped with the plastic part 21
Fluid groove 23 in communication, the micro device are adhered to the surface of the plastic part 21.
Preferably, the transmission mechanism 11 includes energy-storage units and vibration unit, wherein the energy-storage units are arranged on institute
State between vibration unit and the cavity head, the vibration unit activates under the driving of the actuating unit 12 and along vertical
The energy-storage units are exerted a force in the direction of the outlet end 2, the energy-storage units are stored up with the liquid in the cavity head
Storehouse 3 connects, and by activating with automatically open up it is described can openend so that it is described can openend connect with the prefabricated fluid hole 22
It is logical, promote liquid sequentially pass through it is described can openend, the prefabricated fluid hole 22 and the micro device.Touched by pressure
Hair, then drives cavity head to vibrate by transmission mechanism 11, then due to the effect of inertia, can throw away liquid and come.I.e. one
Face micropin touches skin, while goes out liquid.Relative to a traditional face micropin, another side goes out liquid, and use is more convenient.Certainly it is above-mentioned it is intended that
It can absolutely prove the present embodiment, the transmission mechanism 11 described in the present embodiment is not limited to this.As alternating current can also be formed
Above-mentioned vibration, i.e., it is any to make the circular motion of actuating unit 12 being converted into the device of linear movement in the present embodiment
Within protection domain.
Preferably, the micro device is nanometer solid microneedles or nanometer solid array of microneedles, it is pierced into skin keratin
The length of layer is between 4 microns to 2000 microns.It is further preferable that the micro device is pierced into the length of keratoderma 20
Micron is between 100 microns.And hollow microneedles are different from, nanometer solid microneedles or nanometer solid array of microneedles are manufactured into
This is relatively low, yield is high, qualification rate is also high, and its administering position and precision more can be controlled accurately.
Preferably, the liquid reservoir 3 includes the first bank 31 and the second bank 32, and 31 front end of the first bank is equipped with
The outlet end 2, second bank 32 are connected with first bank 31.In a preferred embodiment, first bank
31 are prepared for flexible material, and second bank 32 is prepared for hard material, first bank 31 and described the
Two banks 32 are arranged connection.In another preferred embodiment, first bank 31 is prepared for hard material, and described second
Bank 32 is prepared for flexible material, and first bank 31 is arranged with second bank 32 and is connected.Above-mentioned hard material
Can be ABS, POM, PS, PMMA, PC, PET, PBT, PPO material etc., soft material can be soft pvc, K glue (BS), TPE,
TPR, EVA, TPU material etc..Material selection to the first bank 31 and second bank 32 is intended in order to which the two is in connection
It is more convenient, while manufacturing cost is relatively low.Certainly others connection mode, such as clamping, absorption type connection, welding, integration
Deng can implement, also within protection scope of the present invention.
Preferably, as shown in Figure 3 (omitting micro device), the centre on the plastic part 21 is precast equipped with one
Fluid apertures 22, the fluid groove 23 (are cross in attached drawing, but annular those skilled in the art should know in cross or annular
Dawn, so it will not be repeated) and connected with the prefabricated fluid hole 22.It is well known that in the prior art mainly in nanocrystalline on piece
Punching, therefore not only its preparation difficulty is higher, also be easy to cause the breakage of micropin etc., so its processing and manufacturing cost are all too
It is high.And the application then looks for another way, by the advance perforate on plastic part 21, then by being connected with the liquid reservoir 3,
On the premise of ensureing that liquid smoothly imports, preparation process is enormously simplify, reduces production cost.
Preferably, a charging interface is additionally provided with the housing 1, for supplementing electricity to power module.
Preferably, the control mechanism 5 is one or more control button, and engine is controlled by the control button
Structure 12 operates.Certainly, the present embodiment can also include some other instruction button, such as the charge condition of instruction battery, charge and discharge
Electric situation etc..
Preferably, the actuating unit 12 is motor.
Preferably, the energy-storage units are spring, and the vibration unit is hertz oscilltor.
The operation principle of the present embodiment is：With an energy-storage units, vibrating mechanism and liquid reservoir 3 (replaceable head)
Separate, after forcing up, energy-storage units are compressed, and vibrating mechanism is just combined with liquid reservoir 3.Just driven after being combined
Cavity head vibration, with the method for a preset pressure activation vibration, ensure user when using can only vertical pressing, without
It is to slide on the skin.Therefore skin can be protected not to be subject to scratch and injury.And while vibration, due to the work of inertia
With, liquid can be thrown away and, while air can enter, so like this, the liquid of liquid reservoir 3 can persistently go out
Come, until whole liquid transfers are clean, so there is no need to design special liquid discharge device.In single vibration, can accurately it control
Liquid outlet quantity is between 0.01mL to 100mL.
The present invention is combined together medicine and administration device, and structure is simpler and reasonable.And to administering mode into
Great change is gone, there is provided a kind of a kind of novel medicine feeding side between traditional injection and traditional cutaneous penetration
Method, i.e., with the mode of similar injection, liquid quality by liquid reservoir 3, be delivered to skin epidermis surface, spread through epidermis, passed through
Cross epidermal absorption (or into blood circulation of human body).Since the mode being synchronously administered is set, i.e., touch skin in nanometer solid microneedles
While go out liquid, use is more convenient.What is more important, Medicated Permeation and absorption are more preferable.Additionally by nanometer solid microneedles
Or nanometer solid array of microneedles, cuticula is opened, liquid is slowly controlled, does not have the generation of the phenomenon of leakage, while can essence
Dosage is controlled accurately, reduces manufacture cost.
Using liquid quantitative conveying device of the present invention, the efficiency and quality of cutaneous penetration can be increased substantially,
Illustrated below with testing.
Experiment one, with the device of the invention, loads onto 2mL physiological saline in cavity head, cavity head is placed in position vertically downward
Put, be not turned on vibration mode, liquid is no to flow out naturally because of gravity.When turning on the power switch, cavity head is set to contact human body
Skin, when activation cavity head is vibrated with 5000 times per minute, liquid liquid reservoir 3 out of cavity head is transferred to skin table naturally
Face, by the duct size and vibration frequency of prefabricated fluid hole 22, can adjust Fluid transport rate.Table 1 is under different frequency
Liquid all shifts the required time, and the wherein aperture is 1mm.
Table 1
| Frequency (secondary/second) | Transfer time (minute) |
| 65 | 25 |
| 83 | 18 |
| 100 | 15 |
Experiment two, the lidocaine gel that autogamy is compared in this experiment are handled in no nanometer chip and handled with nanometer chip
Transdermal absorption after 20 seconds.Pig ear in refrigerator is taken, takes 800 μ m-thick of skin, removes the hair on surface, until smooth.PBS (7.4) soaks
Bubble is cut into reception tank outer rim size, the instrument of the nanometer chipset present invention (is equipped with a height of 150 microns of dot matrix after 10-15 minutes
Nanometer chip), act on 20s, be placed between reception tank and administration pond, 37 ± 0.2 DEG C of PBS (7.4) balance 1h.Spread with Franze
Pond, dosage 120mg, reception tank volume 2.5mL, actual transdermal area 0.66cm2, reception liquid is PBS (7.4), temperature 37 ±
0.2 DEG C, magnetic agitation 280rmp.
As seen from Figure 4 (wherein ◆ be nanometer chipset, ■ is control group), when being acted on without nanometer chip, lidocaine
Transdermal effect is poor, and the lidocaine less than 5% being capable of percutaneous absorbtion；After nanometer chip is synchronized to medicine, lidocaine coagulates
The transdermal effect of glue is obviously improved.It is most unexpected to be that while that lidocaine gel viscosity is higher, remain able to from being invented
Liquid reservoir 3, via mechanism, skin surface was transferred in 40 seconds, and quantify transdermal penetration, is successfully examined in acceptance pool
Measure lidocaine medicine.
The foregoing description of the disclosed embodiments, enables professional and technical personnel in the field to realize or use the present invention.
A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, it is of the invention
The embodiments shown herein is not intended to be limited to, and is to fit to and the principles and novel features disclosed herein phase one
The most wide scope caused.
Claims (10)
- A kind of 1. liquid quantitative conveying device, it is characterised in that including：One housing, it is externally provided with a handle sturcture, control mechanism and a connecting end surface, it is built-in with transmission mechanism, actuating unit And power module, the transmission mechanism produce linear movement under the driving of the actuating unit, the actuating unit with it is described Power module connects, and the control mechanism controls the actuating unit action；One cavity head, it include outlet end and with can openend liquid reservoir, the outlet end upper surface be equipped be used for only Penetrate the micro device of keratoderma；The liquid reservoir is built-in with liquid, its can openend be connected with the outlet end, its The other end is connected with the connecting end surface of the housing, and is connected under pressure with the transmission mechanism.
- 2. liquid quantitative conveying device as claimed in claim 1, it is characterised in that：The outlet end is equipped with a plastic part, Prefabricated fluid hole and fluid groove in communication are equipped with the plastic part, the micro device is adhered to the plastic part Surface.
- 3. liquid quantitative conveying device as claimed in claim 1 or 2, it is characterised in that：The transmission mechanism includes energy storage list Member and vibration unit, wherein the energy-storage units are arranged between the vibration unit and the cavity head, the vibration unit Activated under the driving of the actuating unit and exert a force to the energy-storage units along perpendicular to the direction of the outlet end, The energy-storage units are connected with the liquid reservoir in the cavity head, and by activating with automatically open up it is described can openend, make It is described can openend connected with the prefabricated fluid hole, promote liquid sequentially pass through described in can openend, described precast liquid Hole and the micro device.
- 4. the liquid quantitative conveying device as described in claim 1-3 is any, it is characterised in that：The micro device is real for nanometer Heart micropin or nanometer solid array of microneedles, it is pierced into the length of keratoderma between 4 microns to 2000 microns.
- 5. the liquid quantitative conveying device as described in claim 1-4 is any, it is characterised in that：The liquid reservoir includes first Bank and the second bank, the first bank front end are equipped with the outlet end, and second bank is connected with first bank.
- 6. liquid quantitative conveying device as claimed in claim 2, it is characterised in that：Centre on the plastic part is set Fluid apertures is precast described in having, the fluid groove is connected in cross or annular and with the prefabricated fluid hole.
- 7. the liquid quantitative conveying device as described in claim 1-6 is any, it is characterised in that：The control mechanism for one or The multiple control buttons of person.
- 8. the liquid quantitative conveying device as described in claim 1-7 is any, it is characterised in that：One is additionally provided with the housing to fill Electrical interface.
- 9. the liquid quantitative conveying device as described in claim 1-8 is any, it is characterised in that：The actuating unit is motor.
- 10. liquid quantitative conveying device as claimed in claim 3, it is characterised in that：The energy-storage units are spring, described to shake Moving cell is hertz oscilltor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610883873.0A CN107913459A (en) | 2016-10-10 | 2016-10-10 | A kind of liquid quantitative conveying device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610883873.0A CN107913459A (en) | 2016-10-10 | 2016-10-10 | A kind of liquid quantitative conveying device |
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| CN107913459A true CN107913459A (en) | 2018-04-17 |
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| CN201610883873.0A Withdrawn CN107913459A (en) | 2016-10-10 | 2016-10-10 | A kind of liquid quantitative conveying device |
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Cited By (7)
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| CN108815697A (en) * | 2018-07-05 | 2018-11-16 | 陈彦彪 | The super crystallite beauty gun of receiving of one kind |
| CN109966635A (en) * | 2019-03-04 | 2019-07-05 | 北京化工大学 | It is a kind of for transmitting the micropin percutaneous plaster and its pushing meanss of liquid macromolecular drug |
| WO2020114403A1 (en) * | 2018-12-06 | 2020-06-11 | 苏州纳通生物纳米技术有限公司 | Medicinal liquid introduction head and drug delivery device |
| WO2021036076A1 (en) * | 2019-08-23 | 2021-03-04 | 苏州纳生微电子有限公司 | Quantitative liquid supply device |
| WO2021036075A1 (en) * | 2019-08-23 | 2021-03-04 | 苏州纳生微电子有限公司 | Fixed-quantity liquid supply method |
| CN115430033A (en) * | 2022-09-21 | 2022-12-06 | 上海交通大学医学院附属第九人民医院 | Hand-held type device of dosing |
| CN116421870A (en) * | 2023-04-24 | 2023-07-14 | 中国人民解放军空军军医大学 | Skin wound surface medicine applying device |
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| CN108815697A (en) * | 2018-07-05 | 2018-11-16 | 陈彦彪 | The super crystallite beauty gun of receiving of one kind |
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| WO2021036075A1 (en) * | 2019-08-23 | 2021-03-04 | 苏州纳生微电子有限公司 | Fixed-quantity liquid supply method |
| CN115430033A (en) * | 2022-09-21 | 2022-12-06 | 上海交通大学医学院附属第九人民医院 | Hand-held type device of dosing |
| CN116421870A (en) * | 2023-04-24 | 2023-07-14 | 中国人民解放军空军军医大学 | Skin wound surface medicine applying device |
| CN116421870B (en) * | 2023-04-24 | 2023-11-07 | 中国人民解放军空军军医大学 | Skin wound surface medicine applying device |
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