KR20070018410A - Transdermal patch having micro-scale needle array and method for manufacturing the same - Google Patents

Abstract

The present invention relates to a transdermal patch for delivering a drug into the body through the skin and a method of manufacturing the same, and more particularly, to a transdermal patch formed by forming a painless microneedle array on a skin attachment surface so as to be used to increase skin absorption rate of a drug It relates to a patch and a method of manufacturing the same. The transdermal patch of the present invention includes a support sheet having a surface attached to one side of the skin while a plurality of fine needles are formed on the surface attached to the skin to form a fine needle array; And a drug-containing matrix layer formed by uniformly dispersing a drug in the pressure-sensitive adhesive is applied to the skin adhesion surface of the support sheet.

According to the patch of the present invention, it is possible to increase the transdermal absorption rate of the drug by using the microneedle array, it is possible to promptly introduce the drug through the skin, it is possible to administer the drug through the skin without pain. In addition, the patch of the present invention can be used as a patch or mask pack for supplying various nutrients and functional substances to the skin in addition to the purpose of drug injection.

Transdermal patch, microneedle array, drug delivery system, photo etching, dry etching, DRIE

Description

Transdermal patch having micro-scale needle array and method for manufacturing the same

1 is a cross-sectional view showing a first embodiment of the transdermal patch according to the present invention,

Figure 2 is a perspective view showing a support sheet having a fine needle array in the patch of the present invention,

3 is a perspective view showing several examples of the shape of the fine needle provided in the patch of the present invention,

Figures 4a to 4g is a process chart showing a process for forming and forming a support sheet and fine needle array in the present invention,

5 is a cross-sectional view showing a second embodiment of the transdermal patch according to the present invention;

6A is a cross-sectional view showing a bonding state of upper and lower molds for forming a support sheet according to a second embodiment of the present invention;

6B is a cross-sectional view illustrating a state in which a polymer is injected into the upper and lower molds of FIG. 6A;

6C is a cross-sectional view showing the entire mold.

<Explanation of symbols for the main parts of the drawings>

1a, 1b: transdermal patch 10: support sheet

11: fine needle 11a: hollow

11b: hole shape 11c: channel

12 fine needle array 13 polymer

20: matrix layer 30: protective film

40: mold 40a: cavity

41 silicon substrate 42 oxide film

43: photoresist 44: pattern

50: adhesive layer 60: backing layer

61: storage space

The present invention relates to a transdermal patch for delivering a drug into the body through the skin and a method of manufacturing the same, and more particularly, to a transdermal patch formed by forming a painless microneedle array on a skin attachment surface so as to be used to increase skin absorption rate of a drug It relates to a patch and a method of manufacturing the same.

Generally, a method for delivering a drug into the body includes taking a drug, injecting the drug through injection, or absorbing the drug through the skin.

Among these methods, oral administration, or medication, may cause central nervous system side effects such as headache, drowsiness, dizziness, and nervousness and serious gastrointestinal side effects such as nausea, indigestion, diarrhea, peptic ulcer, gastrointestinal bleeding, and perforation. As a result, their use is limited to short-term therapy.

In addition, the method of injecting the drug by injection inserts the needle directly through the skin to inject the drug directly into the body, so the absorption is rapid, but it is cumbersome to be administered only by a specialist (difficult to self-administer), and it is usually Since needles are used, patient compliance is poor due to pain during injection.

In order to eliminate the side effects and defects described above, the development of a drug delivery system (drug delivery system) by transdermal administration is being actively made.

In general, the drug to be absorbed through the skin is formulated in the form of a liquid, cream, gel, etc., liquid, cream or gel is difficult to adjust the dosage characteristics in the nature of the formulation, there is a problem that sticky or coating contamination.

Therefore, a method of attaching a patch containing a drug (hereinafter referred to as a transdermal patch) to the skin and absorbing the drug through the skin has been used.

The drug administration method using the transdermal patch absorbs the drug through the skin, thereby preventing side effects such as first-pass effects, gastrointestinal disorders, and food effects, and eliminating pain and discomfort during injection. And, due to its convenience, the use is increasing gradually in recent years.

In addition, since the drug is continuously released from the polymer matrix at a constant rate, the number of administrations can be reduced, and the drug concentration in the body can be kept constant within the effective blood concentration range, thereby minimizing side effects, and when side effects are manifested, immediately administer. Because of the ability to stop the nonsteroidal anti-inflammatory drugs, scopolamine, nitroglycerin, fentanyl, clonidine, testosterone, nicotine, estradiol and other drugs are widely applied.

Transdermal patches are classified into two types depending on the structure and composition of the layer containing the drug.

The matrix type is to control the release of the drug by dispersing the drug in the matrix layer of the polymer or adhesive, the storage layer type is to store the drug in the storage space formed between the film to control the release through a certain membrane and to design the adhesive layer separately .

Among these, the storage layer type transdermal patch generally includes a drug-impermeable backing layer through which drugs cannot pass, a drug-permeable drug permeable membrane, and an adhesive layer that adheres the patch to the skin. The storage space is provided between the backing layer and the drug permeable membrane.

On the other hand, the biggest disadvantage of such transdermal patches is that the absorption rate of the drug through the skin is very low, so the function of the skin's penetration barrier should be reduced. Generally, the rate of drug absorption through the transdermal patch is known to be approximately 20%. As a method for improving the absorption rate, chemical methods such as the use of a skin absorption accelerator, prodrug use, and physical methods such as iontophoresis and electrophoresis are known.

However, even if these known methods are used, there is still a limit to improving the drug absorption rate to a satisfactory level. Therefore, in order to expect the drug efficacy, excessive drug use is inevitable in consideration of the absorption rate.

In particular, the type of skin absorption accelerator is determined according to the design type of the formulation to be used or the physicochemical properties of the component, and a certain level or more is required to have an effect, and when the skin absorption accelerators are added, It is not easy to prevent crystal formation, and there is a disadvantage in that adhesive properties such as adhesion and cohesion are unsuitably changed for use.

In addition, the technology that uses electricity has a problem that the patch has to have a battery, an electrode, a circuit and other parts, and the composition of the product is not only complicated, but also large and expensive, and a large amount of waste occurs after use. have.

Therefore, the present invention has been invented to solve the above problems, by forming a painless microneedle array on the skin adhesion surface, it is possible to increase the percutaneous absorption of the drug using this microneedle array, through the skin It is an object of the present invention to provide a transdermal patch and a method of manufacturing the same, which enables rapid drug administration and enables the administration of drugs through the skin without pain.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

The transdermal patch having the microneedle array according to the present invention is, as a first embodiment,

A support sheet having one surface attached to the skin and having a plurality of fine needles protruding from the surface attached to the skin to form a fine needle array;

A drug-containing matrix layer formed by uniformly dispersing a drug in the pressure-sensitive adhesive is applied to the skin adhesion surface of the support sheet;

It is characterized by including.

And, a transdermal patch having a fine needle array according to the present invention, as a second embodiment,

A support sheet having one surface attached to the skin and having a plurality of fine needles protruding from the surface attached to the skin to form a fine needle array;

An adhesive layer formed on the skin adhesion surface of the support sheet;

A backing layer coupled to the other side of the support sheet to form a storage space in which drugs can be stored between the support sheet;

And a channel penetrating through the support sheet along the inside of the microneedle so that the drugs in the storage space can be discharged to each of the microneedle so that drugs can be injected through the microneedle array. Is there.

In addition, the present invention, by etching the silicon substrate to form a mold for forming a support sheet formed with a plurality of cavities for fine needle molding on the upper surface;

Injecting a liquid polymer onto the upper surface on which the cavity is formed, and curing the liquid polymer to form a support sheet forming a microneedle array by protruding a plurality of fine needles on one surface attached to the skin;

Applying an adhesive onto the skin adhesion surface on which the fine needle array of the support sheet is formed, and uniformly dispersing the drug in the adhesive to form a drug-containing matrix layer;

Characterized in the method for producing a transdermal patch having a fine needle array comprising a.

In addition, the present invention comprises the steps of fabricating the upper mold and the lower mold for forming a support sheet having a fine needle array channel formed by etching the silicon substrate;

The support sheet is formed by joining the upper mold and the lower mold by injecting a liquid polymer into the molding space between the two molds through the injection hole of the upper mold, and then curing them to protrude a fine needle array having a channel formed on one side attached to the skin. Shaping;

Combining the backing layer to the opposite side of the skin attachment surface of the support sheet, and filling and storing a drug in a storage space between the support sheet and the backing layer;

Applying an adhesive onto the skin attachment surface where the fine needle array of the support sheet is formed;

Characterized in the method for producing a transdermal patch having a fine needle array comprising a.

Hereinafter, the present invention will be described in more detail with reference to the accompanying drawings.

The present invention relates to a transdermal patch for delivering a drug to the body through the skin, and has an emphasis on increasing the percutaneous absorption rate of the drug by providing a microneedle array capable of painless treatment on the skin attachment surface of the patch.

1 is a cross-sectional view showing a first embodiment of the transdermal patch according to the present invention, Figure 2 is a perspective view showing a support sheet having a fine needle array in the patch of the present invention, Figure 3 is provided in the patch of the present invention It is a perspective view which shows the various examples of the shape of a fine needle.

As shown in the drawing, the first embodiment of the patch according to the present invention is provided with the fine needle array 12 formed on the surface 10a attached to the skin while one surface is attached to the skin 10a. An adhesive is applied to the supporting sheet 10 and the skin attachment surface 10a of the supporting sheet 10, and the drug-containing matrix layer 20 formed by uniformly dispersing the drug in the adhesive.

The patch 1a made as described above may further include a drug impermeable protective film 30 which can be removed while covering the matrix layer 20 and the fine needle array 12, which is the matrix layer 20 and As a film for protecting the fine needle array 12, in use, the protective film 30 is removed, and then the exposed matrix layer 20 is attached to the skin to fix the patch.

Among them, the support sheet 10 and the fine needle array 12 formed thereon may be molded and manufactured using a polymer harmless to the human body. For example, polymethylmethacrylate (PMMA), a polymer of suture material , Polydimethylsiloxane (PDMS), polycarbonate (PC), polypropylene (PP), polyethylene (PE), polyester and the like, but is not limited thereto.

As a material of the support sheet 10 and the fine needle array 12, in the case of using a known polymer that can be molded into a desired shape and can be dissolved in the skin, in particular, a material used as a material of a suture (melting thread) Because it is a material that melts on the skin, even if the microneedle is inserted into the skin, it will be harmless to the skin.

As described above, one side of the support sheet 10 is a surface (hereinafter referred to as skin attachment surface) 10a attached to the skin, and the plurality of fine needles 11 are attached to the skin attachment surface 10a. Formed and provided in a predetermined arrangement, each of the fine needles 11 in the support sheet 10 is provided in a columnar shape protruding to a predetermined height from the skin attachment surface (10a).

At this time, each of the fine needle 11 may be provided with a structure in which the hollow (11a) is formed inside the columnar shape, the size of the fine needle 11 can be scratched in the skin epidermis, painless or low pain, for example, 20㎛ ~ 2mm It is preferably provided with a width of 20㎛ ~ 1mm in length.

In addition, the shape of the painless fine needle 11 may be provided in various shapes such as a circular column, a polygonal column such as a hexagon, a rectangle, a triangle, or a cross pillar as shown in FIG. 3, but is not limited thereto. no.

In the support sheet 10, the microneedle 11 may be uniformly distributed at a predetermined interval on a part or the entire surface of the skin attachment surface 10a, and, if necessary, the fine needle at a specific portion of the skin attachment surface 10a. The density of (11) can be distributed differently from other parts (the density of the fine needle can be adjusted relatively large or small in a specific part appropriately).

In addition, preferably, a metal coating layer 14 of a conductor may be further formed on the skin attachment surface 10a on which the fine needles 11 are formed, including the surface of each fine needle 11 in the support sheet 10. .

Even if the metal coating layer 14 is not available, it can be used as a drug delivery device, but when a weak voltage is applied, the drug penetrates faster by iontophoresis. It needs to exist.

Accordingly, a metal coating layer 14 is formed by coating a conductive metal on the surface of the microneedle 11 and the skin attachment surface 10a of the support sheet 10 based on the plastic material, and then the surface of the microneedle array 12 as an electrode. When used, the drug delivery ability can be made more always.

As the metal coating layer material, gold, silver platinum, which is harmless to a human body, may be used.

The metal coating layer 14 may be formed by a sputtering method which is widely used for depositing a metal thin film. The metal coating layer 14 may be electrically conductive on the surface of the fine needle 11 and the entire skin adhesion surface 10a of the support sheet 10 using a sputtering apparatus. The metal is formed by sputter deposition.

Meanwhile, in order to manufacture the support sheet 10 as described above, an intaglio mold is required in order to mold a desired shape of the fine needle 11, which is formed from a silicon substrate using a semiconductor manufacturing process and equipment. It can manufacture.

In other words, by using a mold made of a silicon substrate it is possible to form a large amount of painless fine needles on the plane of the support sheet through a plastic molding process.

Herein, the support sheet constituting the patch of the present invention, in particular, a method of forming and manufacturing a support sheet having a fine needle array will be described in more detail as follows.

Figures 4a to 4g is a process chart showing a process for forming and forming a support sheet and a fine needle array in the present invention, Figures 4a to 4f shows a process for manufacturing a mold, Figure 4g is supported using a manufactured mold The process of molding the sheet and the fine needle is shown.

For reference, although a mold 40 having one cavity 40a is formed in each drawing, and one fine needle 11 is formed using the cavity 40a, this shows that individual fine needle molding is performed through the drawings. It is only for clarity that a mold having a plurality of cavities arranged on the upper surface is manufactured, and thus a fine needle array (see FIG. 2) formed of a plurality of fine needles 11 is formed on a plane of the support sheet 10. Reveal.

First, the silicon substrate 41 is prepared and cleaned to remove metal residues, organic matters, and the like, and then the cleaned silicon substrate is placed in an oxidation furnace and oxidized with DI water (deionized water) to form a silicon oxide film (SiO ₂ ) ( 42) (FIGS. 4A and 4B).

Next, a photoresist coating process of rotating baking the photoresist (PR) 43 on the oxide film 42 (FIG. 4C) and then performing a soft baking is performed, followed by a fine needle cross-sectional shape (actual In the process, the photoresist pattern 44 from which the photoresist of the portion corresponding to the fine needle array cross-sectional shape is removed is formed (FIG. 4D).

Specifically, an exposure step of transferring a fine needle cross-sectional shape (which becomes a fine needle array cross-sectional shape in an actual process) to the photoresist 43 of FIG. 4C coated over the oxide film 42, and not exposed or exposed using a developing solution. A developing process of leaving the unused portion is performed. First, in the exposing step, a photomask in which a pattern of a fine needle cross-sectional shape is formed in the process of selectively exposing a predetermined portion of the photoresist 43 is used. The photomask is irradiated with light in the ultraviolet region to transfer the fine needle cross-sectional phenomenon to the photoresist and then post-baked.

Subsequently, the photoresist pattern 44 as shown in FIG. 4D is formed by removing the photoresist in a portion corresponding to the microneedle cross section using a developing solution and then performing hard baking.

Subsequently, the silicon oxide film 42 exposed by the photoresist pattern 44 is selectively etched with an etching mask to expose the surface of the substrate 41 to open the etching window 45 having a fine needle cross-sectional structure (FIG. 4E). Thereafter, the photoresist pattern 44 is removed through a PR strip process, and the etching residues existing in the etching window 45 are removed through a cleaning process.

After the photoresist pattern is completely removed, the cavity 40a for forming a fine needle shape on the silicon substrate 41 exposed through the etching window 45 by using deep reactive ion etching (DRIE) equipment among semiconductor manufacturing equipment. ) Is formed by etching (Fig. 4F).

As described above, the silicon substrate 41 having the fine needle-shaped cavity 40a is used as a mold for molding the fine needle array 12 and the support sheet 10.

DRIE is a selective dry etching technique that injects a reactive gas that reacts only to a specific material. Among the dry etching techniques, the DRIE uses a reactive gas for ion acceleration.

In general, when dry etching is performed using a DRIE device, vertical etching may be performed even for a pattern having a few μm.

By dry etching the desired depth vertically to the exposed silicon substrate 41 using the DRIE equipment, the cavity 40a for forming a fine needle shape can be formed, and the silicon substrate 41 is formed through the DRIE method. In the present invention, it is possible to form a cavity 40a for needle molding having a fine width of 100 μm or less and a desired length.

In particular, when the silicon substrate 41 is etched by using the DRIE method, a microneedle is manufactured by manufacturing a silicon mold 40 having an aspect ratio of 1:50 to 1: 100 with a width of several μm to 100 μm or less. Alternatively, ultrafine needles can be molded in large quantities.

The depth of the cavity to be formed can be adjusted by controlling the process conditions according to the size of the fine needle to be molded, and depending on the design of the photoresist pattern, polygonal columns such as circular columns, hexagonal, square, triangle, or cross columns It is possible to form a cavity of various shapes such as.

Due to the advantage of dry etching, it is possible to produce any shape in the vertical direction from the silicon substrate. For example, when a dry etching of 100 μm is performed after the cross pattern is formed on the surface of the silicon substrate, 100 μm is used. A cavity of depth is created.

As described above, since the silicon substrate is manufactured as a mold by using the DRIE, the resolution of the mold is due to the minimum line width that can be etched by the DRIE, and the minimum fabricable size is about several μm to 100 μm.

As described above, in order to manufacture and manufacture the support sheet 10 having the fine needle array 12 in the present invention, a mold for forming the support sheet by performing a photolithography and a DRIE process on the silicon substrate 41 is performed. 40 is first manufactured (FIG. 4F), the polymer 13, which is a material of the support sheet 10, is introduced into the final mold 40, and the mold is filled (FIG. 4G), and the polymer 13 When the mold is cured and then demolded from the mold 40, the supporting sheet 10 having the fine needle array 12 as shown in FIG. 2 can be completed.

In this way, after the support sheet 10 is manufactured as described above, the metal coating layer 14 is deposited and formed on the surface of the fine needle and the skin attachment surface 10a, and then the adhesive is applied thereon to apply the drug to the adhesive. By uniformly dispersing to form the drug-containing matrix layer 20, the transdermal patch 1a of the present invention having the fine needle array 12 can be produced.

The transdermal patch 1a of the present invention can be used painlessly because the size of the fine needle 11 is smaller than the pain point size on the skin epidermis.

That is, by using a fine needle (11) a little scratch on the skin epidermis painlessly attached to the skin and used, the drug is injected into the skin in the scratched state can be penetrated through the skin more quickly have.

The percutaneous patch of the present invention may be used as a patch or mask pack for supplying nutrients (vitamin C, etc.) to the skin in addition to the purpose of drug injection to inject the drug into the body through the skin, and to correct wrinkles according to skin aging. Can also be used as.

On the other hand, Figure 5 is a cross-sectional view showing a second embodiment of the transdermal patch according to the present invention, as follows.

In the second embodiment of the patch according to the present invention, the support sheet 10 is provided with a fine needle array 12 formed on a surface 10a attached to one side of the skin while the surface 10a is attached to one side of the skin. ), The pressure-sensitive adhesive layer 50 formed on the skin attachment surface 10a of the support sheet 10, and the other 10b surface of the support sheet 10, and are attached to the drug between the support sheet 10. It comprises a backing layer 60 to form a storage space 61 that can be stored, in particular, so that each of the fine needle 11 of the support sheet 10 can be discharged drug of the storage space 61 A channel 11c penetrating the support sheet 10 is formed along the inside of the fine needle 10.

The patch 1b made as described above may further include a drug-impermeable protective film 30 that can be removed while covering the adhesive layer 50 and the fine needle array 12, which is an adhesive layer 50 and As a film for protecting the fine needle array 12, in use, this protective film 30 is peeled off, and the exposed adhesive bond layer 50 is attached to skin, and a patch is fixed.

In the patch 1b of the second embodiment, the drug is stored between the support sheet 10 and the backing layer 60, and the backing layer 60 has an edge bonded to the edge of the support sheet 10 ( Heat-adhesive), the inner part of the backing layer 60 is convexly spaced apart from the support sheet 10, so that a drug can be stored between the backing layer 60 and the support sheet 10. The storage space 61 is provided.

The backing layer 60 may be formed of a film having heat adhesiveness and no light and drug permeability, and although not shown, may be filled with a material capable of holding a drug such as cotton or sponge in the storage space 61. In addition, a separate support structure may be installed between the backing layer 60 and the support sheet 10 to prevent the backing layer 60 from being pressed by an external force.

In the second embodiment, the support sheet 10 on which the fine needle array 12 is formed is similar to that of the first embodiment described above, except that the microneedle 11 is filled in the storage space 61 with the fine needle 11 inserted into the skin. There is a difference in that through channels 11c through which drugs can flow are formed in each of the fine needles 11 so that the drugs can be directly injected into the skin through the fine needles 11.

Unlike the hollow 11a of the first embodiment, the channel 11c of each fine needle 11 is formed so as to completely penetrate the support sheet 10, and thus, a storage space between the support sheet 10 and the backing layer 60. At 61, fluid is allowed to enter and exit through the channel 11c of the fine needle 11.

In the second embodiment, the shape and dimensions of the microneedle array 12 and the material of the support sheet 10 may be the same as those of the first embodiment, and the surface of the microneedle 11 in the support sheet 10 may be the same. And further forming the metal coating layer 14 of the conductor on the skin attachment surface 10a may also be carried out in the same manner.

Hereinafter, in describing the second embodiment, the description of the same parts as the first embodiment of the shape and dimensions of the fine needle 11, the arrangement state, the material and the manufacturing process of the support sheet 10 will be omitted. Shall be.

In order to manufacture a support sheet having a through channel 11c formed in each of the fine needles 11 so that the fluid can flow, the mold 40 manufactured according to the process of FIGS. 4A to 4F is divided into a lower mold (hereinafter referred to as a lower mold). ), And a separate mold (hereinafter referred to as the upper mold) 70 for use as the upper mold is further produced.

The upper mold 70 is manufactured through a process similar to the lower mold 40.

However, using a separate silicon substrate 71, but after the process in the method of Figures 4a to 4f, and finally to form the hole shape (11b) of each fine needle 11 through the DRIE etching The upper part 70 is manufactured by etching away the remaining part to a predetermined depth, leaving only the hole forming part 72 for the same.

The upper mold 70 is formed to penetrate through (through the DRIE etching) the injection hole 73 for use to inject the liquid polymer 13 during the DRIE etching.

Subsequently, as shown in FIG. 6A, the upper mold 70 is turned upside down to be bonded to the lower mold 40 so that the hole forming portion 72 of the upper mold 70 is fine needle of the lower mold 40. The upper mold 70 and the lower mold 40 are aligned and bonded to be bonded to the portion 40b which forms the hollow 11a.

6B and 6C, when the liquid polymer 13 is injected into the molding space between the upper mold and the lower mold through the injection hole 73 of the upper mold 70, the support sheet 10 is eventually formed. ) Is formed, and in particular, a channel 11c through which the hole shape 11b and the hollow portion 11a are connected to penetrate the fine needle 11 is formed in the center portion of each fine needle 11.

6C is a sectional view of the entire mold.

The transdermal patch 1b of the second embodiment including the support sheet 10 manufactured as described above removes the protective film 30 and then removes the skin attachment surface 10a of the patch 1b on which the fine needle array 12 is formed. It is used to adhere to the skin, the microneedle array 12 is inserted into the skin in a painless state so that the drug is injected it is possible to more quickly drug administration.

The storage layer type transdermal patch 1b of the second embodiment can be used for the same purpose as the matrix layer transdermal patch 1a of the first embodiment, and other drugs can be injected without pain through the microneedle array 12. Thus, it can be used as an injection for young children and also freed from the pain of using a conventional needle for those who frequently need to administer the injection.

As described above, according to the transdermal patch according to the present invention, by forming a fine needle array capable of a painless procedure on the skin adhered surface of the patch, there are the following effects.

1) The microneedle array is added and used as compared to the conventional patch, so that the absorption rate of the drug through the skin can be increased, and the drug can be injected more quickly.

2) Painless drug administration is possible by using a microneedle array.

3) It can be used as a patch or mask pack to supply various nutrients (vitamin C, etc.) and functional substances to the skin in addition to the purpose of drug injection, and can also be used for wrinkle correction according to skin aging.

Claims (16)

A support sheet having one surface attached to the skin and having a plurality of fine needles protruding from the surface attached to the skin to form a fine needle array; A drug-containing matrix layer formed by uniformly dispersing a drug in the pressure-sensitive adhesive is applied to the skin adhesion surface of the support sheet; Transdermal patch having a fine needle array comprising a. The method according to claim 1, A transdermal patch having a microneedle array further comprising a drug-impermeable protective film that can be removed while covering the matrix layer and the microneedle array. The method according to claim 1, The fine needle is a transdermal patch having a fine needle array, characterized in that formed in a width of 20㎛ ~ 2mm and a length of 20㎛ ~ 1mm. The method according to claim 1 or 3, The fine needle is a transdermal patch having a fine needle array, characterized in that formed in the shape of a circular column, a polygonal column, or a cross-shaped column having a hollow. The method according to claim 1, The percutaneous patch having a fine needle array, characterized in that the conductive sheet is coated on the skin attachment surface including a fine needle surface in the support sheet. The method according to claim 1, The support sheet is selected from polymethylmethacrylate (PMMA), polydimethylsiloxane (PDMS), polycarbonate (PC), polypropylene (PP), polyethylene (PE), polyester, and polymers used as suture materials. Transdermal patch having a fine needle array, characterized in that one of the materials. A support sheet having one surface attached to the skin and having a plurality of fine needles protruding from the surface attached to the skin to form a fine needle array; An adhesive layer formed on the skin adhesion surface of the support sheet; A backing layer coupled to the other side of the support sheet to form a storage space in which drugs can be stored between the support sheet; And a channel penetrating the support sheet along the inside of the microneedle so that the drugs of the storage space can be discharged to each of the microneedles so that drugs can be injected through the microneedle array. Percutaneous patch which has fine needle array to assume. The method according to claim 7, A transdermal patch having a microneedle array further comprising a drug-impermeable protective film that can be removed while covering the adhesive layer and the microneedle array. The method according to claim 7, The microneedle is a transdermal patch having a microneedle array, characterized in that formed in a width of 20㎛ ~ 2mm and a length of 20㎛ ~ 1mm. The method according to claim 7 or 9, The fine needle is a transdermal patch having a fine needle array, characterized in that formed in the shape of a circular column, a polygonal column, or a cross-shaped column with a channel formed therein. The method according to claim 7, The percutaneous patch having a fine needle array, characterized in that the conductive sheet is coated on the skin attachment surface including a fine needle surface in the support sheet. The method according to claim 7, The support sheet is selected from polymethylmethacrylate (PMMA), polydimethylsiloxane (PDMS), polycarbonate (PC), polypropylene (PP), polyethylene (PE), polyester, and polymers used as suture materials. Transdermal patch having a fine needle array, characterized in that one of the materials. Etching the silicon substrate to produce a mold for forming a support sheet having a plurality of cavities arranged on the upper surface thereof for forming fine needles; Forming a support sheet constituting a microneedle array by inserting a liquid polymer onto the upper surface of the cavity and curing the liquid polymer, thereby forming a plurality of fine needles protrudingly formed on one surface attached to the skin; Applying an adhesive onto the skin adhesion surface on which the fine needle array of the support sheet is formed, and uniformly dispersing the drug in the adhesive to form a drug-containing matrix layer; Method of producing a transdermal patch having a fine needle array comprising a. The method according to claim 13, The method of manufacturing a transdermal patch having a fine needle array, characterized in that it further comprises the step of coating the conductive metal coating layer on the skin attachment surface including the surface of the fine needle in the support sheet. Etching the silicon substrate to produce an upper mold and a lower mold for forming a support sheet having a channeled fine needle array; The support sheet is formed by joining the upper mold and the lower mold by injecting a liquid polymer into the molding space between the two molds through the injection hole of the upper mold, and then curing them to protrude a fine needle array having a channel formed on one side attached to the skin. Shaping; Combining the backing layer to the opposite side of the skin attachment surface of the support sheet, and filling and storing a drug in a storage space between the support sheet and the backing layer; Applying an adhesive onto the skin attachment surface where the fine needle array of the support sheet is formed; Method of producing a transdermal patch having a fine needle array comprising a. The method according to claim 15, The method of manufacturing a transdermal patch having a fine needle array, characterized in that it further comprises the step of coating the conductive metal coating layer on the skin attachment surface including the surface of the fine needle in the support sheet.

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