WO2021097963A1 - 一种一次性不渗漏颅内给药装置 - Google Patents

一种一次性不渗漏颅内给药装置 Download PDF

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Publication number
WO2021097963A1
WO2021097963A1 PCT/CN2019/124625 CN2019124625W WO2021097963A1 WO 2021097963 A1 WO2021097963 A1 WO 2021097963A1 CN 2019124625 W CN2019124625 W CN 2019124625W WO 2021097963 A1 WO2021097963 A1 WO 2021097963A1
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Prior art keywords
drug delivery
tube
cap
drug
delivery tube
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PCT/CN2019/124625
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English (en)
French (fr)
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贾香连
王立平
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中国科学院深圳先进技术研究院
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Publication of WO2021097963A1 publication Critical patent/WO2021097963A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0077—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of chemical or pharmacological stimulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

Definitions

  • This application relates to the field of life science technology, for example, to a disposable non-leaky intracranial drug delivery device.
  • This application proposes a disposable non-leaky intracranial drug delivery device, which can better ensure that the injection reagent does not leak, thereby ensuring the accuracy of the experimental results.
  • a disposable non-leakage intracranial drug delivery device comprising: a drug delivery tube configured to contain a reagent or an optical fiber, both ends of the drug delivery tube are open, and the drug delivery tube One end is provided with a glue seal, the glue seal is configured to be absorbed by the tissue of the experimental animal; a drug delivery cap, the drug delivery cap includes a drug tube cap and a thimble, the drug tube cap is connected to the drug delivery tube The other end is used to close the drug delivery tube, the thimble is detachably connected to the drug tube cap, the thimble is fitted in the drug delivery tube, and the thimble is configured to push the reagent out of the drug delivery tube. Medicine tube.
  • one end of the drug delivery tube is provided with an external thread
  • the drug tube cap is provided with an internal thread that matches with the external thread
  • an elastic sealing ring is provided between the drug delivery tube and the drug tube cap.
  • the end of the thimble away from the drug delivery cap is provided with a rubber stopper, and the outer side wall of the rubber stopper is attached to the inner side wall of the drug delivery tube.
  • the cross section of the drug delivery tube is circular, the cross section of the thimble is circular, and the diameter of the thimble is smaller than the diameter of the drug delivery tube.
  • a scale is provided on the outer peripheral wall of the drug delivery tube.
  • the drug delivery tube is a round tube, and the diameter of the drug delivery tube is 180 um-220 um.
  • the drug delivery tube is a Teflon tube.
  • the thimble and the drug delivery cap are detachably connected by threads.
  • the disposable non-leakage intracranial drug delivery device of the present application has a detachable thimble on the drug delivery cap, which realizes the function of adding drug stimulation or light stimulation to the experimental animal by the disposable non-leakage intracranial drug delivery device.
  • the scope of application of the disposable non-leakage intracranial drug delivery device is expanded; since the end of the drug delivery tube with a glue seal can be directly buried in the specific brain area of the animal to achieve the injection of reagents, it can better solve the problem of drugs and viruses.
  • Fig. 1 is a schematic structural diagram of a drug delivery tube of a disposable non-leaky intracranial drug delivery device according to a specific embodiment of the present application;
  • Fig. 2 is a schematic structural diagram of a drug delivery cap of a disposable non-leaky intracranial drug delivery device provided by a specific embodiment of the present application.
  • Drug delivery cap 21, drug tube cap; 22, thimble; 23, rubber stopper;
  • first and second may explicitly or implicitly include one or more of these features, which are used to distinguish and describe the features, without ordering, and without distinction.
  • plural means two or more.
  • connection should be understood in a broad sense, unless otherwise clearly specified and limited.
  • it can be a fixed connection or a detachable connection.
  • Connected or integrally connected it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication between two components.
  • connection should be understood in a broad sense, unless otherwise clearly specified and limited.
  • it can be a fixed connection or a detachable connection.
  • Connected or integrally connected it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication between two components.
  • the specific meanings of the above-mentioned terms in this application can be understood under specific circumstances.
  • the disposable non-leaky intracranial drug delivery device of the embodiment of the present application includes a drug delivery tube 1 and a drug cap 2.
  • the drug delivery tube 1 is configured to contain reagents or contain optical fibers,
  • the two ends of the tube 1 are open, and one end of the drug delivery tube 1 is provided with a glue seal 3, which is configured to be absorbed by the tissue of the experimental animal.
  • the drug delivery cap 2 includes a drug tube cap 21 and a thimble 22, and a drug tube cap 21 is connected to the other end of the dosing tube 1 to seal the dosing tube 1, the thimble 22 is detachably connected to the cap 21 of the dosing tube, the thimble 22 is fitted in the dosing tube 1, and the thimble 22 is configured to push the reagent out of the dosing Tube 1.
  • the disposable non-leakage intracranial drug delivery device of the present application has two working modes, one is a drug delivery mode, and the other is a light stimulation mode.
  • the glue seal 3 is used to seal one end of the drug delivery tube 1, and then a virus or drug is injected into the drug delivery tube 1.
  • the thimble 22 is installed on the drug tube cap 21
  • the drug tube cap 21 is covered on the dosing tube 1 to seal the dosing tube 1, and then the end of the dosing tube 1 with the glue seal 3 is buried in the specific brain area of the experimental animal.
  • the tissue of the experimental animal can absorb the glue seal 3, and at this time, push the thimble 22 to inject the reagent into the specific brain area of the experimental animal.
  • the function of injecting drugs or viruses into brain tissue can be achieved, and the function of injecting drugs or viruses into brain tissue can be achieved.
  • the glue seal 3 is used to seal one end of the dosing tube 1, the thimble 22 is removed from the tube cap 21, the optical fiber is inserted into the dosing tube 1, and the dosing tube 1 has a glue seal.
  • One end of 3 is buried in a specific brain area of the experimental animal. After a certain period of time, the tissue of the experimental animal can absorb the glue seal 3, and the optical fiber can enter the specific brain area of the experimental animal, thereby realizing the function of adding light stimulation.
  • the drug delivery cap 2 can be removed, the thimble 22 can be removed from the drug tube cap 21, and the optical fiber can be inserted into the drug delivery tube 1 to achieve light stimulation.
  • the function of continuing to add light stimulation can be achieved without a second operation.
  • the disposable non-leaky intracranial drug delivery device of the present application since the drug delivery cap 2 is provided with a detachable thimble 22, the disposable non-leaky intracranial drug delivery device can be used to add drug stimulation or light stimulation to the experimental animal.
  • the function expands the scope of application of the disposable non-leakage intracranial drug delivery device; since the end of the drug delivery tube 1 with the glue seal 3 can be directly embedded in the specific brain area of the animal to achieve the injection of reagents, it is a better solution Drugs and viruses are caused by problems such as the need to withdraw the injection needle and the leakage of drugs; because the drug delivery tube 1 is embedded into the animal’s brain area, and the drug delivery cap 2 and the drug delivery tube 1 are detachable, the drug The cap 21 and the thimble 22 are detachable, so that after the drug delivery device is stimulated by the drug, the function of continuing to add light stimulation can be realized without a second operation.
  • one end of the drug delivery tube 1 is provided with an external thread
  • the drug tube cap 21 is provided with an internal thread that cooperates with the external thread. It is understandable that the drug tube 1 and the drug tube cap 21 are connected by threads, on the one hand, the stability of the connection between the drug tube 1 and the drug tube cap 21 is ensured, and the phenomenon of the drug tube cap 21 falling off is better avoided; On the other hand, the sealing ability of the medicine tube cap 21 is improved, and it is better to ensure that after the medicine tube cap 21 is fitted in the medicine tube 1, the inside of the medicine tube 1 is in a relatively closed space, which better avoids reagent contamination The phenomenon occurs, thereby ensuring the accuracy of the experimental results.
  • the drug delivery tube 1 and the drug tube cap 21 can also be fitted in directions such as interference fit, connector connection, etc., and are not limited to the threaded fit of this embodiment.
  • an elastic sealing ring is provided between the drug tube 1 and the drug tube cap 21.
  • the end of the thimble 22 away from the drug delivery cap 2 is provided with a rubber stopper 23, and the outer side wall of the rubber stopper 23 is attached to the inner side wall of the drug delivery tube 1. Therefore, when the end of the drug delivery tube 1 with the glue seal 3 is buried in the brain area of the experimental animal, the operator will push the drug delivery cap 2 smoothly so that the thimble 22 can inject the drug into the drug delivery tube 1 The phenomenon that remains inside occurs.
  • the cross section of the drug delivery tube 1 is circular
  • the cross section of the thimble 22 is circular
  • the diameter of the thimble 22 is smaller than the diameter of the drug delivery tube 1. It is understandable that, since one end of the thimble 22 is provided with a rubber stopper 23, and the outer side wall of the rubber stopper 23 is attached to the inner side wall of the drug delivery tube 1, if the diameter of the thimble 22 is equal to the diameter of the drug delivery tube 1, it will As a result, when the user pushes the thimble 22, the friction between the outer side wall of the thimble 22 and the inner side wall of the drug delivery tube 1 is relatively large, which is not conducive for the operator to inject the reagent into the brain area of the experimental animal.
  • the outer side wall of the rubber stopper 23 is attached to the inner side wall of the drug delivery tube 1, and the diameter of the thimble 22 is smaller than the diameter of the drug delivery tube 1, so that the user can push the thimble 22 very easily. So that the reagent can be smoothly injected into the brain area of the experimental animal.
  • the cross section of the drug delivery tube 1 and the thimble 22 is not limited to a circular shape, but can be selected according to actual conditions.
  • a scale is provided on the outer peripheral wall of the drug delivery tube 1. It is understandable that the outer peripheral wall of the drug delivery tube 1 is provided with scales. On the one hand, it is convenient for the operator to embed the drug delivery tube 1 in the brain of the experimental animal according to actual needs, and the operator can realize accurate embedding according to the scale. On the other hand, the operator can control the amount of reagent injected according to actual needs, so as to achieve precise process control of the experiment.
  • the drug delivery tube 1 is a round tube, and the diameter of the drug delivery tube 1 is 180 um-220 um. It is understandable that if the diameter of the drug delivery tube 1 is too large, it will be difficult to embed it, while the diameter of the drug delivery tube 1 is too small and it is inconvenient to inject. In this embodiment, the diameter of the drug delivery tube 1 is controlled to be between 180um and 220um. It is convenient for the operator to bury the drug delivery tube 1 and also for the operator to inject the medicine. Of course, in other embodiments of the present application, the diameter of the drug delivery tube 1 can be selected according to actual needs, and is not limited to the range of 180um-220um in this embodiment.
  • the drug delivery tube 1 is a Teflon tube. It is understandable that the storage temperature of drugs and viruses is usually -80°. Teflon has good low temperature resistance, which avoids the phenomenon of freezing and cracking of the drug delivery tube 1 when the drug is injected into the drug delivery tube 1.
  • the drug delivery tube 1 can also be a stainless steel tube, a silicon tube, or a chemical fiber tube, and is not limited to the Teflon tube in this embodiment.
  • the thimble 22 and the drug delivery cap 2 are detachably connected by threads. Therefore, the operator can easily install and disassemble the thimble 22 and the drug delivery cap 2, thereby facilitating the operator to switch between the drug delivery work mode and the light stimulation mode.
  • the disposable non-leakage intracranial drug delivery device of this embodiment includes a drug delivery tube 1 and a drug cap 2.
  • the drug delivery tube 1 is configured to contain a reagent or an optical fiber.
  • One end of the tube 1 is provided with a glue seal 3, the glue seal 3 is configured to be absorbed by the tissue of the experimental animal,
  • the drug delivery cap 2 includes a drug tube cap 21 and a thimble 22, the drug tube cap 21 is connected to the drug delivery tube by a threaded connection structure
  • the other end of 1 is used to close the drug delivery tube 1.
  • the thimble 22 and the drug cap 2 are detachably connected by threads.
  • the thimble 22 fits in the drug delivery tube 1.
  • the cross section of the drug delivery tube 1 is circular, and the cross section of the thimble 22 It is circular, and the diameter of the thimble 22 is smaller than the diameter of the drug delivery tube 1.
  • the end of the thimble 22 away from the drug delivery cap 2 is provided with a rubber stopper 23, and the outer side wall of the rubber stopper 23 is attached to the inner side wall of the drug delivery tube 1.
  • the advantage of the disposable non-leakage intracranial drug delivery device of this embodiment is that the drug delivery tube 1 can be embedded once, light stimulation or drug stimulation can be achieved, and no secondary surgery is required. After the drug delivery tube 1 is embedded, Carrying drugs or viruses into the brain tissue perfectly solves the problems of virus and drug leakage caused by drugs and viruses due to the need to withdraw the injection needle.

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Abstract

一种一次性不渗漏颅内给药装置，其包括给药管(1)和给药帽(2)，给药管(1)被配置为盛装试剂或者容纳光纤，给药管(1)的两端敞开设置，给药管(1)的一端设有胶水封口(3)，胶水封口(3)被配置为能够被实验动物的组织吸收，给药帽(2)包括药管帽(21)和顶针(22)，药管帽(21)连接在给药管(1)的另一端以封闭给药管(1)，顶针(22)可拆卸地连接在药管帽(21)上，顶针(22)配合在给药管(1)内，顶针(22)被配置为将试剂推出给药管(1)。

Description

一种一次性不渗漏颅内给药装置
本申请要求在2019年11月18日提交中国专利局、申请号为201911127331.0的中国专利申请的优先权，以上申请的全部内容通过引用结合在本申请中。
技术领域
本申请涉及生命科学技术领域，例如涉及一种一次性不渗漏颅内给药装置。
背景技术
神经生物学的研究在国内外如火如荼展开。研究核团的功能，我们常常需要在目的脑区注射药物，功能性病毒等。病毒注射完成后，需要停针5-10分钟，保证病毒颗粒能最大剂量融合进目的脑区。但是在针抽离脑区时候，病毒颗粒还是会顺着针道渗漏。导致病毒不但感染目的脑区，针道上的脑区也会被感染。在用药物遗传学等操纵病毒感染神经元的时候，这些针道上脑区中的神经元活动也会被直接影响。导致读取的行为学、生理参数等指标并不一定是由于目的脑区活动导致的，从而对实验结果产生了不良影响。
发明内容
本申请提出一种一次性不渗漏颅内给药装置，该一次性不渗漏颅内给药装置能够较好地保证注射试剂不渗漏，从而保证实验结果的准确性。
一种一次性不渗漏颅内给药装置，包括：给药管，所述给药管被配置为盛装试剂或者容纳光纤，所述给药管的两端敞开设置，所述给药管的一端设有胶水封口，所述胶水封口被配置为能够被实验动物的组织吸收；给药帽，所述给药帽包括药管帽和顶针，所述药管帽连接在所述给药管的另一端以封闭所述给药管，所述顶针可拆卸地连接在所述药管帽上，所述顶针配合在所述给药管内，所述顶针被配置为将所述试剂推出所述给药管。
在一些实施例中，所述给药管的一端上设有外螺纹，所述药管帽上设有与所述外螺纹配合的内螺纹。
在一些可选的实施例中，所述给药管与所述药管帽之间设有弹性密封圈。
在一些实施例中，所述顶针的远离所述给药帽的一端设有橡皮塞，所述橡皮塞的外侧壁贴合在所述给药管的内侧壁上。
在一些可选的实施例中，所述给药管的横截面为圆形，所述顶针的横截面为圆形，所述顶针的直径小于所述给药管的直径。
在一些可选的实施例中，所述给药管的外周壁上设有刻度。
在一些可选的实施例中，所述给药管为圆管，所述给药管的直径为180um-220um。
在一些可选的实施例中，所述给药管为特氟龙管。
在一些可选的实施例中，所述顶针与所述给药帽通过螺纹可拆卸连接。
本申请的一次性不渗漏颅内给药装置，由于给药帽上设有可拆卸的顶针，实现了一次性不渗漏颅内给药装置朝向实验动物添加药物刺激或光刺激的功能，扩大了一次性不渗漏颅内给药装置的适用范围；由于给药管的具有胶水封口的一端能够直接埋设在动物的特定脑区以实现试剂的注入，较好地解决了药物和病毒因为注射针需要抽出等问题带来的病毒、药物渗漏问题；由于给药管的采用埋设的方式进入动物的脑区，且给药帽与给药管可拆卸，药管帽与顶针可拆卸，实现了在给药装置在实现药剂刺激之后，不必二次手术即可实现继续添加光刺激的功能。
附图说明
图1是本申请具体实施方式提供的一次性不渗漏颅内给药装置的给药管的结构示意图；
图2是本申请具体实施方式提供的一次性不渗漏颅内给药装置的给药帽的结构示意图。
附图标记：
1、给药管；
2、给药帽；21、药管帽；22、顶针；23、橡皮塞；
3、胶水封口。
具体实施方式
为使本申请解决的技术问题、采用的技术方案和达到的技术效果更加清楚， 下面结合附图并通过具体实施方式来进一步说明本申请的技术方案。
在本申请的描述中，需要理解的是，术语“中心”、“纵向”、“横向”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”、“顺时针”、“逆时针”、“轴向”、“径向”、“周向”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便描述本申请和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本申请的限制。
此外，限定有“第一”、“第二”的特征可以明示或者隐含地包括一个或者更多个该特征，用于区别描述特征，无顺序之分，无轻重之分。在本申请的描述中，除非另有说明，“多个”的含义是两个或两个以上。
在本申请的描述中，需要说明的是，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以具体情况理解上述术语在本申请中的具体含义。
下面参考图1-图2描述本申请实施例的一种一次性不渗漏颅内给药装置的具体结构。
如图1-图2所示，本申请实施例的一次性不渗漏颅内给药装置包括给药管1和给药帽2，给药管1被配置为盛装试剂或者容纳光纤，给药管1的两端敞开设置，给药管1的一端设有胶水封口3，胶水封口3被配置为能够被实验动物的组织吸收，给药帽2包括药管帽21和顶针22，药管帽21连接在给药管1的另一端以封闭给药管1，顶针22可拆卸地连接在药管帽21上，顶针22配合在给药管1内，顶针22被配置为将试剂推出给药管1。
可以理解的是，本申请的一次性不渗漏颅内给药装置具有两种工作模式，一种为给药工作模式，另一种为添加光刺激模式。在给药工作模式下，采用胶水封口3将给药管1的一端封闭，然后在给药管1内注入病毒或者药物等试剂，将顶针22安装在药管帽21上后，将药管帽21盖合在给药管1上以封闭给药管1，之后将给药管1具有胶水封口3的一端埋设在实验动物的特定脑区处。一段时间后，实验动物的组织可以将胶水封口3吸收，此时推动顶针22将试剂注入 实验动物的特定脑区即可。在整个药剂注入的过程中，由于采用的是先埋设给药管1后注入试剂，且注入完成后不必拔出给药管1，这样既能实现药物或者病毒注入脑组织的功能，又能较好地解决药物和病毒因为注射针需要抽出等问题带来的病毒、药物渗漏问题。而在添加光刺激的模式下，采用胶水封口3将给药管1的一端封闭，将顶针22从药管帽21上拆下，将光纤插入给药管1之后将给药管1具有胶水封口3的一端埋设在实验动物的特定脑区处。一端时间后，实验动物的组织可以将胶水封口3吸收，光纤即可进入实验动物的特定脑区，从而实现了增添光刺激的功能。
此外，在实际实验过程中，在实现药剂刺激后可以将给药帽2拆卸下来，将顶针22从药管帽21上拆下，在给药管1内插入光纤实现光刺激，也就是说本实施例的一次性不渗漏颅内给药装置在实现药剂刺激之后，可以不用二次手术即可实现继续添加光刺激的功能。
本申请的一次性不渗漏颅内给药装置，由于给药帽2上设有可拆卸的顶针22，实现了一次性不渗漏颅内给药装置朝向实验动物添加药物刺激或光刺激的功能，扩大了一次性不渗漏颅内给药装置的适用范围；由于给药管1的具有胶水封口3的一端能够直接埋设在动物的特定脑区以实现试剂的注入，较好地解决了药物和病毒因为注射针需要抽出等问题带来的病毒、药物渗漏问题；由于给药管1的采用埋设的方式进入动物的脑区，且给药帽2与给药管1可拆卸，药管帽21与顶针22可拆卸，实现了在给药装置在实现药剂刺激之后，不必二次手术即可实现继续添加光刺激的功能。
在一些实施例中，给药管1的一端上设有外螺纹，药管帽21上设有与外螺纹配合的内螺纹。可以理解的是，给药管1和药管帽21通过螺纹连接，一方面保证了给药管1与药管帽21的连接稳定性，较好地避免了药管帽21脱落的现象发生；另一方面提升了药管帽21的密封能力，较好地保证了药管帽21配合在给药管1内后，给药管1内处于较为密闭的空间，较好地避免了试剂被污染的现象发生，从而保证了实验结果的准确性。当然，在本申请的其他实施例中，给药管1和药管帽21也可以通过过盈配合、连接件连接等方向配合，并不限于本实施例的给螺纹配合。
在一些可选的实施例中，给药管1与药管帽21之间设有弹性密封圈。由此， 可以进一步提提神给药管1和药管帽21之间的密封性能，从而进一步避免试剂被污染的现象发生。
在一些实施例中，顶针22的远离给药帽2的一端设有橡皮塞23，橡皮塞23的外侧壁贴合在给药管1的内侧壁上。由此，当给药管1的具有胶水封口3的一端埋入实验动物脑区后，操作人员较为顺利地推动给药帽2从而使得顶针22将药剂注入过程中，避免药剂在给药管1内残留的现象发生。
在一些可选的实施例中，给药管1的横截面为圆形，顶针22的横截面为圆形，顶针22的直径小于给药管1的直径。可以理解的是，由于顶针22的一端设有橡皮塞23，且橡皮塞23的外侧壁贴合在给药管1的内侧壁上，如果顶针22的直径与给药管1的直径相等，会导致用户推动顶针22时，顶针22的外侧壁与给药管1内侧壁之间的摩擦力较大，不利于操作人员朝向实验动物脑区注入试剂。而在本实施例中，橡皮塞23的外侧壁贴合在给药管1的内侧壁上，且顶针22的直径小于给药管1的直径，这样能够使得用户非常容易地推动顶针22，从而使得试剂能够被顺利的注入实验动物的脑区。当然，这里需要额外说明的是，在本申请的其他实施例中，给药管1和顶针22的截面并不限于圆形，而是可以根据实际情况做出选择。
在一些可选的实施例中，给药管1的外周壁上设有刻度。可以理解的是，给药管1的外周壁上设有刻度，一方面方便了操作人员根据实际需要将给药管1埋设在实验动物的脑部，操作人员能够根据刻度实现精准埋设。另一方面，操作人员可以根据实际需要控制注入的试剂量，从而实现实验的精准过程控制。
在一些可选的实施例中，给药管1为圆管，给药管1的直径为180um-220um。可以理解的是，给药管1的直径过大会提升埋设困难，而给药管1的直径过小则不方便注入，在本实施例中，将给药管1的直径控制在180um-220um之间，既能方便操作人员进行给药管1的埋设，又能方便操作人员进行药剂注入。当然，在本申请的其他实施例中，给药管1的直径可以根据实际需要做出选择，并不限于本实施例的180um-220um范围。
在一些可选的实施例中，给药管1为特氟龙管。可以理解的是，通常药物、病毒的存储温度在-80°。特氟龙的耐低温性能较好，避免了将药剂注入给药管1时给药管1冻裂的现象发生。当然，在本申请的其他实施例中，给药管1还可 以为不锈钢管、硅管或者化纤管等管件，并不限于本实施例中的特氟龙管。
在一些可选的实施例中，顶针22与给药帽2通过螺纹可拆卸连接。由此，操作人员可以十分方便的进行顶针22与给药帽2的安装与拆卸，从而方便了操作人员进行给药工作模式和添加光刺激模式之间切换。
实施例：
下面参考图1-图2描述本申请一个具体实施例的一次性不渗漏颅内给药装置的具体结构。
本实施例的一次性不渗漏颅内给药装置包括给药管1和给药帽2，给药管1被配置为盛装试剂或者容纳光纤，给药管1的两端敞开设置，给药管1的一端设有胶水封口3，胶水封口3被配置为能够被实验动物的组织吸收，给药帽2包括药管帽21和顶针22，药管帽21通过螺纹连接结构连接在给药管1的另一端以封闭给药管1，顶针22与给药帽2通过螺纹可拆卸连接，顶针22配合在给药管1内，给药管1的横截面为圆形，顶针22的横截面为圆形，顶针22的直径小于给药管1的直径。顶针22的远离给药帽2的一端设有橡皮塞23，橡皮塞23的外侧壁贴合在给药管1的内侧壁上。
本实施例的一次性不渗漏颅内给药装置的优点在于，实现了一次埋置给药管1，可实现光刺激或者药物刺激，不需要二次手术，给药管1埋置后，携带药物或者病毒进脑组织，完美解决了药物和病毒因为注射针需要抽出等问题带来的病毒、药物渗漏问题。
在本说明书的描述中，参考术语“有些实施例”、“其他实施例”、等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本申请的至少一个实施例或示例中。在本说明书中，对上述术语的示意性表述不一定指的是相同的实施例或示例。而且，描述的具体特征、结构、材料或者特点可以在任何的一个或多个实施例或示例中以合适的方式结合。

Claims (9)

  1. 一种一次性不渗漏颅内给药装置，包括：
    给药管(1)，所述给药管(1)被配置为盛装试剂或者容纳光纤，所述给药管(1)的两端敞开设置，所述给药管(1)的一端设有胶水封口(3)，所述胶水封口(3)被配置为能够被实验动物的组织吸收；
    给药帽(2)，所述给药帽(2)包括药管帽(21)和顶针(22)，所述药管帽(21)连接在所述给药管(1)的另一端以封闭所述给药管(1)，所述顶针(22)可拆卸地连接在所述药管帽(21)上，所述顶针(22)配合在所述给药管(1)内，所述顶针(22)被配置为将所述试剂推出所述给药管(1)。
  2. 根据权利要求1所述的一次性不渗漏颅内给药装置，其中，所述给药管(1)的一端上设有外螺纹，所述药管帽(21)上设有与所述外螺纹配合的内螺纹。
  3. 根据权利要求2所述的一次性不渗漏颅内给药装置，其中，所述给药管(1)与所述药管帽(21)之间设有弹性密封圈。
  4. 根据权利要求1所述的一次性不渗漏颅内给药装置，其中，所述顶针(22)的远离所述给药帽(2)的一端设有橡皮塞(23)，所述橡皮塞(23)的外侧壁贴合在所述给药管(1)的内侧壁上。
  5. 根据权利要求4所述的一次性不渗漏颅内给药装置，其中，所述给药管(1)的横截面为圆形，所述顶针(22)的横截面为圆形，所述顶针(22)的直径小于所述给药管(1)的直径。
  6. 根据权利要求1所述的一次性不渗漏颅内给药装置，其中，所述给药管(1)的外周壁上设有刻度。
  7. 根据权利要求1所述的一次性不渗漏颅内给药装置，其中，所述给药管(1)为圆管，所述给药管(1)的直径为180um-220um。
  8. 根据权利要求1所述的一次性不渗漏颅内给药装置，其中，所述给药管(1)为特氟龙管。
  9. 根据权利要求1所述的一次性不渗漏颅内给药装置，其中，所述顶针(22)与所述给药帽(2)通过螺纹可拆卸连接。
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