WO2021081899A1 - 样本分析设备及其控制方法 - Google Patents

样本分析设备及其控制方法 Download PDF

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Publication number
WO2021081899A1
WO2021081899A1 PCT/CN2019/114746 CN2019114746W WO2021081899A1 WO 2021081899 A1 WO2021081899 A1 WO 2021081899A1 CN 2019114746 W CN2019114746 W CN 2019114746W WO 2021081899 A1 WO2021081899 A1 WO 2021081899A1
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Prior art keywords
reagent
command
reagents
status
shielding
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PCT/CN2019/114746
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English (en)
French (fr)
Inventor
邓爱华
魏明
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深圳迈瑞生物医疗电子股份有限公司
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Priority to PCT/CN2019/114746 priority Critical patent/WO2021081899A1/zh
Publication of WO2021081899A1 publication Critical patent/WO2021081899A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Definitions

  • the invention relates to the technical field of sample analysis, in particular to a sample analysis device and a control method thereof.
  • Sample analysis equipment is a machine used to analyze and measure samples. Generally, reagents are added to the sample, and the chemical composition and concentration in the sample are measured in a certain way on the sample after the reaction with the reagent.
  • the sample analysis equipment may include, for example, a biochemical analyzer, an immune analyzer, and a cell analyzer.
  • the present invention mainly provides a sample analysis device and a control method thereof to simplify the problem of encountering abnormal reagents.
  • an embodiment provides a sample analysis device, including:
  • the sample part is used to carry the sample container containing the sample
  • the sample adding mechanism is used to suck a sample from the sample container to be tested placed at the sample component, and discharge the sucked sample into the reaction container to be added;
  • the reagent component includes a plurality of reagent placement positions for carrying a plurality of reagent containers, and the reagent container is used for accommodating reagents;
  • a reagent adding mechanism for sucking reagents from the reagent container placed at the preset position of the reagent component, and discharging the sucked reagent into the reaction container to be added;
  • the processor is at least used to control the sample adding mechanism to add samples according to the current test item, and to control the reagent adding mechanism to draw reagents from the reagent container placed at the preset position of the reagent component, and respond to the reagent shielding command to control the The reagent adding mechanism avoids the reagent pointed to by the reagent mask command when adding reagents.
  • an embodiment provides a method for controlling a sample analysis device, including:
  • an embodiment provides a control device for a sample analysis device, including:
  • an embodiment provides a computer-readable storage medium, including a program, and the program can be executed by a processor to implement the method according to any embodiment of the present application.
  • the sample analysis device and the control method of the above-mentioned embodiment since it can avoid the reagent pointed to by the reagent shielding command when the reagent adding mechanism is controlled to add reagents, it can be avoided by pointing the reagent shielding command to the abnormal reagent during the test. Open abnormal reagents without unloading abnormal reagents, which simplifies operations when encountering abnormal reagents and does not need to interrupt the test, thereby improving test efficiency and user experience.
  • FIG. 1 is a schematic diagram of the structure of a sample analysis device according to an embodiment
  • Fig. 2 is a schematic diagram of a display interface of an embodiment
  • FIG. 3 is a schematic diagram of a display interface of another embodiment
  • 4A and 4B are schematic diagrams of a setting interface of an embodiment
  • Fig. 5 is a flowchart of a control method of a sample analysis device according to an embodiment
  • Fig. 6 is a flowchart of a control method of a sample analysis device according to another embodiment
  • Fig. 7 is a flowchart of a control method of a sample analysis device according to another embodiment.
  • connection and “connection” mentioned in this application include direct and indirect connection (connection) unless otherwise specified.
  • the sample analysis device of an embodiment may include: a sample component 10, a sample adding mechanism 11, a reagent component 12, a reagent adding mechanism 13 and a processor 14.
  • the sample component 10 is used to carry a sample container containing a sample.
  • the sample may be blood, urine, saliva, cerebrospinal fluid, ascites, amniotic fluid, feces, etc., for example.
  • the sample container for accommodating the sample may be, for example, a sample tube, a sample cup, or the like.
  • the sample component 10 for carrying the sample container may be, for example, a sample tray.
  • the sample tray may include a plurality of sample positions where the sample container can be placed. The plurality of sample positions are distributed in a ring shape. The sample tray can be rotated by its disk structure to schedule samples.
  • the position for the sample adding mechanism 11 to aspirate the sample can also be a sample rack
  • the sample rack may include a plurality of sample positions where sample containers can be placed, and the plurality of sample positions are distributed in a matrix.
  • the sample component 10 may also include a sample delivery module (Sample Delivery Module, SDM for short) and a front-end track.
  • SDM Sample Delivery Module
  • the sample adding mechanism 11 is used to suck a sample from the sample container to be tested placed at the sample component 10 and discharge the sucked sample into the reaction container to be sampled.
  • the sample adding mechanism 11 may include, for example, at least one sample needle, and a two-dimensional or three-dimensional drive mechanism is used to drive the sample needle to perform a two-dimensional or three-dimensional movement in space, so that the sample needle can move to aspirate the sample carried by the component 10
  • the test sample is moved to the reaction container to be added, and the sample to be tested is discharged to the reaction container.
  • the reagent component 12 may include a plurality of reagent placement positions for holding a plurality of reagent containers, and the reagent containers are used for accommodating reagents.
  • the reagent component 12 in this embodiment uses a reagent tray as an example, but is not limited to this.
  • the reagent tray is arranged in a disc-shaped structure and has a plurality of reagent placement positions for carrying reagent containers.
  • the reagent tray can Rotating and driving the reagent container carried by it to rotate, so as to rotate the reagent container to a specific position, such as a position where the reagent can be sucked by the reagent adding mechanism 13.
  • the number of reagent parts 12 may be one or more.
  • the reagent adding mechanism 13 is used for sucking reagents from the reagent container placed at the preset position of the reagent component 12 and discharging the sucked reagent into the reaction container to which the reagent is to be added.
  • the reagent adding mechanism 13 may include, for example, at least one reagent needle, and a two-dimensional or three-dimensional drive mechanism is used to drive the reagent needle to perform two-dimensional or three-dimensional movement in space, so that the reagent needle can move to suck the reagent carried by the reagent component 12 , And move to the reaction container where reagents are to be added, and discharge the reagents to the reaction container.
  • the reaction container in this embodiment may be, for example, a reaction cup.
  • the sample analysis device may further include a reaction component 15.
  • the reaction part 15 may include a plurality of placement positions for placing the reaction container.
  • the processor 14 may directly or indirectly communicate with the sample component 10, the sample adding mechanism 11, the reagent component 12, and the reagent adding mechanism 13 respectively.
  • the processor 14 can at least be used to control the sample adding mechanism 11 to add samples according to the current test item, and to control the reagent adding mechanism 13 to draw reagents from the reagent container placed at the preset position of the reagent component 12.
  • the processor 14 may be, for example, a central processing unit (Central Processing Unit, referred to as CPU), or other general-purpose processors, digital signal processors (Digital Signal Processor, referred to as DSP), and application specific integrated circuits (Application Specific Integrated Circuits). Abbreviation: ASIC) and so on.
  • the general-purpose processor may be a microprocessor or the processor may also be any conventional processor or the like.
  • the processor 14 may also respond to the reagent shielding command to avoid the reagent pointed to by the reagent shielding command when the reagent adding mechanism 13 is controlled to add the reagent.
  • the reagent shielding command in this embodiment may include identification information of the reagent that needs to be avoided, and the identification information may include, for example, the position information of the reagent on the reagent component 12, the reagent number, and the like.
  • Reagents that need to be avoided can include abnormal reagents, such as reagents whose results deviate from the required range for quality control testing or sample testing, reagents that have been contaminated during use, etc.; it can also include reagents that do not meet the conditions of use , Such as reagents whose temperature has not reached the required temperature for testing; it can also include reagents that do not need to be used temporarily due to other factors. It should be noted that the reagent masking command can be directed to one or more reagents that need to be avoided.
  • the sample analysis device provided in this embodiment can respond to the reagent masking command and avoid the reagent pointed to by the reagent masking command when the reagent adding mechanism is controlled to add reagents. Therefore, during the testing process, when an abnormal reagent or a suspected abnormal reagent appears , The abnormal reagent can be avoided by pointing the reagent masking command to the abnormal reagent without unloading the abnormal reagent, which simplifies the operation when encountering the abnormal reagent and does not need to interrupt the test, thereby improving the test efficiency and user experience.
  • the sample analysis device can directly analyze the abnormal reagent pointed to by the reagent shielding command when needed, which is easy to operate and can save human resources.
  • the processor when the reagent pointed to by the reagent masking command includes an in-situ reagent, the processor further determines a new in-situ reagent from a plurality of reagents of the same type as the in-situ reagent carried by the reagent component according to a preset reagent selection strategy. Reagents, and control the reagent adding mechanism to draw reagents from the new in-position reagents.
  • the in-situ reagent refers to the reagent determined from the reagents of the same type carried by the reagent component for the reagent adding mechanism to absorb, including but not limited to the currently used reagents.
  • the reagent component can usually carry multiple types of reagents, and there can usually be multiple reagents of the same type.
  • the reagent component is loaded with multiple bottles of reagents A1, A2, and A3 of the same type, and the in-position reagent is A1.
  • the reagent addition mechanism will draw reagents from A1 for testing.
  • test result of the reagent A1 is abnormal, you can mask the reagent A1 by pointing to the reagent mask command to the reagent A1, and determine the new reagent A2 and A3 from the reagents A2 and A3 of the same type as A1 carried by the reagent component according to the preset reagent selection strategy. Reagents for the next test to ensure the smooth progress of the test project.
  • the processor determines a new in-situ reagent from multiple reagents of the same type as the in-situ reagent carried by the reagent component according to a preset reagent selection strategy, which may specifically include: the processor according to the type of the reagent and the remaining amount, expiration date, and At least one item in the calibration state determines a new in-situ reagent from a plurality of reagents of the same type as the in-situ reagent carried by the reagent component.
  • a preset reagent selection strategy may specifically include: the processor according to the type of the reagent and the remaining amount, expiration date, and At least one item in the calibration state determines a new in-situ reagent from a plurality of reagents of the same type as the in-situ reagent carried by the reagent component.
  • the remaining amount, expiration date and calibration status of the reagent can also be considered comprehensively. And other factors.
  • the reagent with the largest remaining amount can be selected from multiple reagents of the same type as the in-place reagent as the new in-place reagent; in order to avoid the expiration of the reagents and cause waste, you can select the reagent from the same type as the in-place reagent.
  • the reagent with the shortest useful life is selected as the new in-situ reagent.
  • the problematic reagent can be shielded (automatic shielding or user selection can be shielded), which can avoid the interruption of the test due to a problematic reagent, and can increase the test speed.
  • the processor is also used to obtain the status of the currently used reagent. If the status of the currently used reagent is abnormal, the processor triggers the reagent masking command.
  • the processor is used to obtain the status of the currently used reagent, which may specifically include: the processor obtains according to at least one of the quality control data of the currently used reagent, the sample test data of the currently used reagent, and the information of the currently used reagent input by the user. The status of the reagent currently in use.
  • the processor In the process of the sample analysis device testing the sample, the processor is also used to obtain the status of the currently used reagent, and once the status of the currently used reagent is detected to be abnormal, it will immediately trigger the reagent masking command. And in response to the reagent masking command, avoiding the currently used reagents, and using the new in-situ reagents to continue the test, so that the current test items can be carried out reliably and accurately.
  • Obtaining the status of the currently used reagent may include, for example, that the quality control data of the currently used reagent does not meet the quality control standard, and/or the test data of the sample using the currently used reagent does not conform to the statistical law of the type of sample, then the current quality control data can be determined
  • the status of the reagent used is abnormal; to obtain the information that the user enters the status of the reagent currently used.
  • the sample analysis equipment also includes a reagent state indicating device, and the processor responds to the reagent shielding command to control the reagent state indicating device to indicate the reagent pointed to by the reagent shielding command.
  • the reagent status indicator device can be implemented through a display screen.
  • the processor controls the display screen to display identification information of the reagent pointed to by the reagent masking command.
  • the reagent status indicator device by setting a reagent status indicator device, and in response to a reagent masking command, the reagent status indicator device is controlled to indicate the reagent pointed to by the reagent masking command, so that the user is changing the reagent carried by the reagent component , When replenishing, it can quickly and accurately identify the reagent pointed to by the reagent mask command, which improves work efficiency.
  • the sample analysis device may also include a display component for displaying on the display interface of the display component for indicating The status identification of each reagent status carried by the reagent component.
  • the status indicator may include, for example, a shielding indicator for identifying that the reagent is avoided, a canceling indicator for identifying that the shielding state of the reagent is cancelled, an indicator for identifying whether the reagent is expired, an indicator for identifying whether the remaining amount of the reagent is sufficient,
  • FIG. 2 is a schematic diagram of a display interface of one embodiment
  • FIG. 3 is a schematic diagram of a display interface of another embodiment.
  • Figures 2 and 3 both show four status flags: reagent masking, invalid reagents, expired reagents, and insufficient balance. In actual use, more or fewer status flags can be included as needed.
  • Figure 2 can be used to show the display interface when the reagent component is a reagent tray. As shown in Figure 2, the numbers 1-18 can represent the position information of the reagents on the reagent tray. Among them, No. 2, No.
  • Figure 3 can be used to show the display interface when the reagent components are distributed in a matrix-type reagent rack. As shown in Figure 3, the number 1-1 indicates that the reagent is located in the first row and the first column on the reagent rack, and the number 2-4 indicates that the reagent is in the The reagent rack is located in the second row and fourth column.
  • reagents 1-4, 2-2, and 3-6 are in the masked state, that is, they are the reagents pointed to by the reagent masking order and need to be avoided when adding reagents; reagent 3-1 is invalid reagent; 2 Reagent -6 has expired; reagent 3-3 is insufficient.
  • Table 1 is a status identification table of the reagents carried by the reagent part displayed on the display interface of the display part in an embodiment. It should be noted that due to space limitations, Table 1 only shows part of the status identifiers of some reagents carried by the reagent components.
  • the number of reagent components in this embodiment is two.
  • position information 1-4 indicates the position 4 of the first reagent component
  • 2-3 indicates the position 3 of the second reagent component.
  • the reagent number can uniquely identify the reagent, for example, it can be obtained by scanning a barcode or a two-dimensional code on the reagent container by a scanning device of the reagent component.
  • the status indicator of the reagent can also be identified by color information. For example, a red indicator can be used for a reagent in a masked state, and a yellow indicator can be used for a reagent with insufficient balance.
  • the display component in this embodiment can be implemented by integrating a display module such as a display screen on the sample analysis device, or it can be connected to a computer device (such as a computer, a smart phone, etc.) in a wired and/or wireless manner. ), which is realized by the screen display status identification of the computer equipment, which all belong to the scope of the limitation and protection of the display component of this application.
  • the processor of the sample analysis device may also respond to the reagent masking command to modify at least part of the status flags of the reagents pointed to by the reagent masking command to mask flags, and the mask flags are used to identify that the reagent is avoided.
  • the processor will respond to the reagent masking command and change the status flag of reagent No. 1-2 to "whether to mask" from "No". Changed to "Yes", that is, one of the status flags of reagent No. 1-2 is changed to a masking flag, which is used to mark that reagent No. 1-2 is avoided when reagents are added.
  • the sample analysis equipment In the process of the sample analysis equipment testing the sample, the user can monitor the testing process according to the statistical law of the sample and their own experience.
  • the sample analysis equipment also provides a human-computer interaction device so that the user can perform related operations. For example, when the user determines that the reagent is abnormal, the status indicator of the reagent can be changed through input devices such as a mouse, a keyboard, and a touch device.
  • the sample analysis device may also include an input detection component for detecting a user's operation on the display interface, and the input detection component may be, for example, a sensor.
  • the sample analysis device can perform corresponding processing according to the user's operation on the display interface.
  • the user When it is detected that the user has modified at least part of the status flags of the reagents to the shielding flags, it outputs a reagent shielding command pointing to the reagent, and the processor responds to the reagent shielding command to avoid the reagent shielding command when the reagent adding mechanism is controlled to add reagents.
  • the pointed reagent when it is detected that the user has modified at least part of the status flag of the reagent to the shielding cancel flag, the shielding cancel command pointing to the reagent is output, and the processor is in response to the shielding canceling command to control the reagent adding mechanism to stop executing the pointing to the reagent
  • the reagent masking command when it is detected that the user has modified at least part of the status flag of the reagent to the shielding cancel flag, the shielding cancel command pointing to the reagent is output, and the processor is in response to the shielding canceling command to control the reagent adding mechanism to stop executing the pointing to the reagent The reagent masking command.
  • the status indicator of the reagent can be modified through the reagent setting interface.
  • FIG. 4A and FIG. 4B are schematic diagrams of a setting interface of an embodiment. It is understandable that when the selected reagent is not currently shielded, its corresponding setting interface is shown in Figure 4A; when the current status of the selected reagent is marked as a shielding flag, its corresponding setting interface is shown in Figure 4B. It should be noted that other reagent setting options may also be included in the setting interface. Since other reagent setting options do not involve the invention of the present application, they are not shown in FIGS. 4A and 4B.
  • the status corresponding to the "whether to cover” column is "Yes”, which means that reagent No. 2-3 is currently covered, and its status is marked as a cover mark, so
  • the corresponding setting interface is shown in Figure 4B.
  • the input detection component of the sample analysis device can detect that the user changes the amount of reagent 2-3 At least part of the status flag is modified to cancel the shielding flag, so the cancel shielding command directed to reagent No. 2-3 is output.
  • the processor changes the status corresponding to the "whether to mask” column of No. 2-3 reagent in Table 1 to "No", and controls the reagent addition mechanism to stop executing the reagent masking command directed to the 2-3 reagent, that is, There is no need to avoid reagents 2-3 when adding reagents.
  • sample analysis device of the present invention Some embodiments of the present invention also disclose a control method of the sample analysis device (hereinafter referred to as the control method).
  • the sample analysis device involved may be the sample analysis disclosed above. equipment.
  • control method of an embodiment may include:
  • Step 100 Control the suction of the reagent according to the current test item.
  • the reagent adding mechanism of the sample analysis device can be controlled according to the current test item to suck reagent from the reagent container placed at the preset position of the reagent component.
  • the reagent to be used can be determined according to the current test item, and then the reagent adding mechanism of the sample analysis device can be controlled to suck the reagent from the corresponding reagent container. Specifically, after determining the reagent to be used, the reagent to be used can be moved to the position where the reagent adding mechanism absorbs the reagent by controlling the moving reagent component such as rotating the reagent disk, or it can be performed by controlling the moving reagent adding mechanism such as driving the reagent needle. The two-dimensional or three-dimensional movement moves the reagent adding mechanism to the position of the reagent to be used to complete the suction work of the reagent.
  • Step 110 In response to the reagent masking command, avoid the reagent pointed to by the reagent masking command. Specifically, in response to the reagent shielding command, when the reagent adding mechanism is controlled to add the reagent, the reagent pointed to by the reagent shielding command is avoided.
  • the reagent masking command in this embodiment may include identification information of the reagent that needs to be avoided, and the identification information may include, for example, position information of the reagent on the reagent component, reagent number, and the like.
  • the reagents that need to be avoided can include abnormal reagents, such as reagents that do not meet the quality control results, reagents that have been contaminated during use, etc.; it can also include reagents that do not meet the conditions of use, such as those whose temperature does not reach the required temperature for testing. Reagents; it can also include reagents that do not need to be used temporarily due to other factors.
  • the reagent mask command can point to multiple reagents that need to be avoided.
  • the control method of the sample analysis device can respond to the reagent shielding command and avoid the reagent pointed to by the reagent shielding command when the reagent adding mechanism is controlled to add reagents. Therefore, during the test process, when an abnormal reagent occurs, The abnormal reagent can be avoided by pointing the reagent masking command to the abnormal reagent without unloading the abnormal reagent, which simplifies the operation when encountering the abnormal reagent and does not need to interrupt the test, thereby improving the test efficiency and user experience.
  • a new in-situ reagent is determined from a plurality of reagents of the same type as the in-situ reagent carried by the reagent component according to a preset reagent selection strategy, and
  • the reagent adding mechanism is controlled to draw reagents from the new in-position reagent, and the in-position reagent refers to the reagent determined from the reagents of the same type carried by the reagent component for the reagent adding mechanism to draw.
  • the meaning of the in-situ reagent can refer to the above-mentioned embodiment and will not be repeated here.
  • the new in-situ reagent is determined from multiple reagents of the same type as the in-situ reagent carried by the reagent component, which can specifically include: according to the type of the reagent and the remaining amount of the reagent, the validity period and the calibration status. At least one item, a new in-situ reagent is determined from a plurality of reagents of the same type as the in-situ reagent carried by the reagent component.
  • control method may further include: acquiring the status of the currently used reagent, and if the status of the currently used reagent is abnormal, triggering a reagent masking command.
  • obtaining the status of the currently used reagent may specifically include: obtaining the currently used reagent according to at least one of the quality control data of the currently used reagent, the sample test data of the currently used reagent, and the information of the currently used reagent input by the user. status.
  • control method may further include: in response to the reagent shielding command, controlling the reagent state indicating device to indicate the reagent to which the reagent shielding command is directed.
  • control method may further include: displaying on the display interface of the sample analysis device a status identifier for indicating the status of each reagent carried by the reagent component.
  • control method may further include: in response to the reagent masking command, modifying at least part of the status flags of the reagent pointed to by the reagent masking command to a masking flag, and the masking flag is used to identify that the reagent is masked.
  • control method may further include: acquiring a first instruction input by the user, where the first instruction is used to instruct to modify at least part of the status identifiers of the reagents into shielding identifiers;
  • a reagent mask command directed to the reagent is output.
  • control method may further include: acquiring a second instruction input by the user, where the second instruction is used to instruct to modify at least a part of the status flags of the reagents to cancel the shielding flags;
  • an unmasking command directed to the reagent is output, and in response to the unmasking command, the reagent adding mechanism is controlled to stop executing the reagent shielding command directed to the reagent.
  • FIG. 6 is a flowchart of a control method of a sample analysis device according to another embodiment.
  • the control method provided in this embodiment may further include:
  • Step 200 Display status identifiers used to indicate the status of each reagent carried by the reagent component on the display interface of the sample analysis device.
  • Step 210 Obtain the instruction input by the user on the display interface.
  • the instruction input by the user may include a first instruction and a second instruction.
  • the first instruction is used to instruct to modify at least part of the status flags of the reagents as shielding flags
  • the second instruction is used to instruct to modify at least part of the status flags of the reagents to be shielded flags.
  • Step 220 Output a control command according to the instruction input by the user.
  • the control commands can include reagent masking commands and unmasking commands. Specifically, if the command input by the user on the display interface is the first command, the reagent masking command directed to the reagent is output; if the command input by the user on the display interface is the second command, the masking cancel command directed to the reagent is output .
  • Step 230 Control the suction of the reagent according to the control command. Specifically, in response to the reagent shielding command, when the reagent adding mechanism is controlled to add reagents, the reagent pointed to by the reagent shielding command is avoided; in response to the canceling shielding command, the reagent adding mechanism is controlled to stop executing the reagent shielding command directed to the reagent.
  • the control method provided by this embodiment realizes a quick response to the user input instruction by acquiring the instruction input by the user on the display interface, and executing the corresponding reagent shielding command or canceling the shielding command according to the instruction input by the user.
  • FIG. 7 is a flowchart of a control method of a sample analysis device according to another embodiment.
  • the control method provided in this embodiment may include:
  • Step 300 Determine whether the remaining amount of the reagent currently used is sufficient. If the margin is sufficient, proceed to step 310. For the case of insufficient margin, reference can be made to the implementation of the prior art, which will not be repeated here.
  • Step 310 Determine whether the state of the currently used reagent is abnormal, and if the state of the currently used reagent is abnormal, continue to perform step 320. Specifically, it can be determined whether the status of the currently used reagent is abnormal according to the quality control data of the currently used reagent, the sample test data of the currently used reagent, and the information of the currently used reagent input by the user.
  • the specific implementation method can refer to the above-mentioned embodiment. For the situation that the current state of the reagent used is normal, reference can be made to the implementation of the prior art, which will not be repeated here.
  • Step 320 Trigger the reagent masking command, and the reagent masking command points to the currently used reagent.
  • Step 330 In response to the reagent masking command, avoid the currently used reagent when the reagent adding mechanism is controlled to add the reagent.
  • Step 340 Determine the new reagent to be used, and control the reagent adding mechanism to draw the reagent from the new reagent to be used.
  • a new reagent to be used can be determined from a plurality of reagents of the same type as the currently used reagent carried by the reagent component according to a preset reagent selection strategy, and the reagent adding mechanism can be controlled to absorb the reagent from the new reagent to be used.
  • the reagent mask command directed to the reagent is triggered to avoid the abnormal reagent, and the new standby reagent is used.
  • An embodiment of the present invention also provides a control device for a sample analysis device, which may include: a reagent adding mechanism for controlling the sample analysis device according to the current test item, and sucking the reagent from the reagent container placed at the preset position of the reagent component
  • the module used to respond to the reagent masking command to avoid the reagent pointed to by the reagent masking command when controlling the reagent adding mechanism to add reagents.
  • the principles herein can be reflected in a computer program product on a computer-readable storage medium, which is pre-installed with computer-readable program code.
  • a computer-readable storage medium Any tangible, non-transitory computer-readable storage medium can be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROM, DVD, Blu Ray disks, etc.), flash memory and/or the like .
  • These computer program instructions can be loaded on a general-purpose computer, a special-purpose computer, or other programmable data processing equipment to form a machine, so that these instructions executed on the computer or other programmable data processing device can generate a device that realizes the specified function.
  • Computer program instructions can also be stored in a computer-readable memory, which can instruct a computer or other programmable data processing equipment to operate in a specific manner, so that the instructions stored in the computer-readable memory can form a piece of Manufactured products, including realizing devices that realize designated functions.
  • Computer program instructions can also be loaded on a computer or other programmable data processing equipment, thereby executing a series of operation steps on the computer or other programmable equipment to produce a computer-implemented process, so that the execution of the computer or other programmable equipment Instructions can provide steps for implementing specified functions.
  • Coupled refers to physical connection, electrical connection, magnetic connection, optical connection, communication connection, functional connection and/or any other connection.

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Abstract

一种样本分析设备及其控制方法，控制方法包括：根据当前测试项目控制样本分析设备的试剂添加机构(13)从放置在试剂部件(12)的预设位置上的试剂容器中吸取试剂(100)；响应于试剂遮蔽命令，在控制试剂添加机构(13)添加试剂时避开试剂遮蔽命令所指向的试剂(110)。由于在控制试剂添加机构(13)添加试剂时能够避开试剂遮蔽命令所指向的试剂，因此在测试过程中，可以通过将试剂遮蔽命令指向异常试剂来避开异常试剂，从而简化了遇到异常试剂时的操作，无需中断测试，进而提高了测试效率和用户体验。

Description

样本分析设备及其控制方法 技术领域
本发明涉及样本分析技术领域，具体涉及一种样本分析设备及其控制方法。
背景技术
样本分析设备，是用于分析和测定样本的机器，一般都是通过向样本中加入试剂，对与试剂反应后的样本通过一定的方式来测得样本中化学成分以及浓度等。样本分析设备例如可以包括生化分析仪、免疫分析仪和细胞分析仪等。
现有样本分析设备，在测试过程中，当出现某试剂异常，需要更换该试剂时，无法直接对该试剂进行操作，只能申请在线试剂装载，而在线试剂装载也需要等待所有已经开始的测试都加完试剂后，才能中止测试以便进行试剂更换。这样不仅耗时长、操作复杂而且需要中断测试，导致测试效率降低。
发明内容
本发明主要提供一种样本分析设备及其控制方法，简化遇到异常试剂的问题。
根据第一方面，一种实施例中提供一种样本分析设备，包括：
样本部件，用于承载容纳有样本的样本容器；
样本添加机构，用于从放置在样本部件处的待测样本容器中吸取样本，并将吸取的样本排放到待加样的反应容器中；
试剂部件，包括多个试剂放置位，用于承载多个试剂容器，试剂容器用于容纳试剂；
试剂添加机构，用于从放置在试剂部件的预设位置上的试剂容器中吸取试剂，并将吸取的试剂排放到待加试剂的反应容器中；以及
处理器，至少用于根据当前测试项目控制样本添加机构进行样本的添加，以及控制试剂添加机构从放置在试剂部件的预设位置上的试剂容 器中吸取试剂，并响应于试剂遮蔽命令，在控制试剂添加机构添加试剂时避开试剂遮蔽命令所指向的试剂。
根据第二方面，一种实施例中提供一种样本分析设备的控制方法，包括：
根据当前测试项目控制样本分析设备的试剂添加机构从放置在试剂部件的预设位置上的试剂容器中吸取试剂；
响应于试剂遮蔽命令，在控制试剂添加机构添加试剂时避开试剂遮蔽命令所指向的试剂。
根据第三方面，一种实施例中提供一种样本分析设备的控制装置，包括：
用于根据当前测试项目，控制样本分析设备的试剂添加机构，从放置在试剂部件的预设位置上的试剂容器中吸取试剂的模块；
用于响应于试剂遮蔽命令，在控制试剂添加机构添加试剂时避开试剂遮蔽命令所指向的试剂的模块。
根据第四方面，一种实施例中提供一种计算机可读存储介质，包括程序，程序能够被处理器执行以实现如本申请任一实施例所述的方法。
依据上述实施例的样本分析设备及其控制方法，由于在控制试剂添加机构添加试剂时能够避开试剂遮蔽命令所指向的试剂，因此在测试过程中，可以通过将试剂遮蔽命令指向异常试剂来避开异常试剂，无需卸载异常试剂，从而简化了遇到异常试剂时的操作，且无需中断测试，进而能够提高测试效率和用户体验。
附图说明
图1为一种实施例的样本分析设备的结构示意；
图2为一种实施例的显示界面的示意图；
图3为另一种实施例的显示界面的示意图；
图4A和图4B为一种实施例的设置界面的示意图；
图5为一种实施例的样本分析设备的控制方法的流程图；
图6为另一种实施例的样本分析设备的控制方法的流程图；
图7为又一种实施例的样本分析设备的控制方法的流程图。
具体实施方式
下面通过具体实施方式结合附图对本发明作进一步详细说明。其中不同实施方式中类似元件采用了相关联的类似的元件标号。在以下的实施方式中，很多细节描述是为了使得本申请能被更好的理解。然而，本领域技术人员可以毫不费力的认识到，其中部分特征在不同情况下是可以省略的，或者可以由其他元件、材料、方法所替代。在某些情况下，本申请相关的一些操作并没有在说明书中显示或者描述，这是为了避免本申请的核心部分被过多的描述所淹没，而对于本领域技术人员而言，详细描述这些相关操作并不是必要的，他们根据说明书中的描述以及本领域的一般技术知识即可完整了解相关操作。
另外，说明书中所描述的特点、操作或者特征可以以任意适当的方式结合形成各种实施方式。同时，方法描述中的各步骤或者动作也可以按照本领域技术人员所能显而易见的方式进行顺序调换或调整。因此，说明书和附图中的各种顺序只是为了清楚描述某一个实施例，并不意味着是必须的顺序，除非另有说明其中某个顺序是必须遵循的。
本文中为部件所编序号本身，例如“第一”、“第二”等，仅用于区分所描述的对象，不具有任何顺序或技术含义。而本申请所说“连接”、“联接”，如无特别说明，均包括直接和间接连接(联接)。
请参照图1，一实施例的样本分析设备可以包括：样本部件10、样本添加机构11、试剂部件12、试剂添加机构13和处理器14。
其中，样本部件10用于承载容纳有样本的样本容器。样本例如可以是血液、尿液、唾液、脑脊液、腹水、羊水、粪便等。用于容纳样本的样本容器例如可以是样本管、样本杯等。用于承载样本容器的样本部件10例如可以是样本盘，样本盘可以包括多个可以放置样本容器的样本位，多个样本位呈环形分布，样本盘通过转动其盘式结构，可以将样本调度到相应位置，例如供样本添加机构11吸取样本的位置；还可以是样本架，样本架可以包括多个可以放置样本容器的样本位，多个样本位呈矩阵式分布。在一些例子中样本部件10还可以包括样本分配模块(Sample Delivery Module，简称：SDM)及前端轨道。
样本添加机构11用于从放置在样本部件10处的待测样本容器中吸取样本，并将吸取的样本排放到待加样的反应容器中。样本添加机构11例如可以包括至少一个样本针，通过二维或三维的驱动机构来驱动样本 针在空间上进行二维或三维的运动，以使样本针可以移动去吸取样本部件10所承载的待测样本，以及移动到待加样的反应容器，并向反应容器排放待测样本。
试剂部件12可以包括多个试剂放置位，用于承载多个试剂容器，试剂容器用于容纳试剂。如图1所示，本实施例中试剂部件12以试剂盘为例进行说明但不限于此，试剂盘呈圆盘状结构设置，具有多个用于承载试剂容器的试剂放置位，试剂盘能够转动并带动其承载的试剂容器转动，以便将试剂容器转动到特定的位置，如可以被试剂添加机构13吸取试剂的位置。试剂部件12的数量可以为一个或多个。
试剂添加机构13用于从放置在试剂部件12的预设位置上的试剂容器中吸取试剂，并将吸取的试剂排放到待加试剂的反应容器中。试剂添加机构13例如可以包括至少一个试剂针，通过二维或三维的驱动机构来驱动试剂针在空间上进行二维或三维的运动，以使试剂针可以移动去吸取试剂部件12所承载的试剂，以及移动到待加试剂的反应容器，并向反应容器排放试剂。
本实施例中的反应容器例如可以是反应杯。可选的，样本分析设备还可以包括反应部件15。反应部件15可以包括多个用于放置反应容器的放置位。
处理器14可以直接或者间接的分别与样本部件10、样本添加机构11、试剂部件12以及试剂添加机构13通信连接。处理器14至少可以用于根据当前测试项目控制样本添加机构11进行样本的添加，以及控制试剂添加机构13从放置在试剂部件12的预设位置上的试剂容器中吸取试剂。处理器14例如可以是中央处理单元(Central Processing Unit，简称：CPU)，还可以是其他通用处理器、数字信号处理器(Digital Signal Processor，简称：DSP)、专用集成电路(Application Specific Integrated Circuit，简称：ASIC)等。通用处理器可以是微处理器或者该处理器也可以是任何常规的处理器等。
进一步的，处理器14还可以响应于试剂遮蔽命令，在控制试剂添加机构13添加试剂时避开试剂遮蔽命令所指向的试剂。本实施例中的试剂遮蔽命令可以包括需要被避开的试剂的标识信息，标识信息例如可以包括试剂在试剂部件12上的位置信息、试剂编号等。需要被避开的试剂可以包括异常试剂，如利用该试剂做质控测试或样本测试其结果偏离要求 范围的试剂、在使用过程中被污染了的试剂等；还可以包括未达到使用条件的试剂，如温度未达到测试所需温度的试剂；还可以包括因其他因素暂时不需要被使用的试剂。需要说明的是试剂遮蔽命令可以指向一个或多个需要被避开的试剂。
本实施例提供的样本分析设备，由于能够响应于试剂遮蔽命令，在控制试剂添加机构添加试剂时避开试剂遮蔽命令所指向的试剂，因此在测试过程中，当出现异常试剂或疑似异常试剂时，可以通过将试剂遮蔽命令指向异常试剂来避开异常试剂，无需卸载异常试剂，从而简化了遇到异常试剂时的操作，且无需中断测试，进而能够提高测试效率和用户体验。现有技术中，当需要对异常试剂进行分析，以确定产生异常的原因时，需要将已经卸载的异常试剂再次装载进样本分析设备，操作复杂且浪费人力资源。而本实施例提供的样本分析设备，可以在需要时，直接对试剂遮蔽命令所指向的异常试剂进行分析，操作简便且能够节省人力资源。
一些实施例中，当试剂遮蔽命令所指向的试剂包括在位试剂时，处理器还根据预设的试剂选择策略从试剂部件承载的与在位试剂同类型的多个试剂中确定新的在位试剂，并控制试剂添加机构从新的在位试剂中吸取试剂。其中，在位试剂是指从试剂部件承载的同种类型的试剂中确定出的供试剂添加机构吸取的试剂，包括但不限于当前使用试剂。
试剂部件通常可以承载多种类型的试剂，同一类型的试剂通常可以有多个。例如，试剂部件装载了同一类型的多瓶试剂A1，A2，A3，在位试剂为A1。在测试(如质控测试或样本测试)过程中，试剂添加机构将从A1中吸取试剂用于进行测试。如果使用试剂A1的测试结果异常，可以通过指向试剂A1的试剂遮蔽命令来遮蔽试剂A1，并根据预设的试剂选择策略从试剂部件承载的与A1同类型的试剂A2和A3中确定新的在位试剂来进行接下来的测试，以确保测试项目的顺利进行。
处理器根据预设的试剂选择策略从试剂部件承载的与在位试剂同类型的多个试剂中确定新的在位试剂，具体可以包括：处理器根据试剂的类型以及试剂的余量、有效期和校准状态中的至少一项，从试剂部件承载的与在位试剂同类型的多个试剂中确定新的在位试剂。
也就是说在确定新的在位试剂时，除了需要考虑试剂的类型，即确保新的在位试剂与原在位试剂具有相同的类型以外，还可以综合考虑试 剂的余量、有效期和校准状态等因素。
例如，为了减少试剂更换的次数，可以从与在位试剂同类型的多个试剂中选择余量最多的试剂作为新的在位试剂；为了避免试剂过期，造成浪费，可以从与在位试剂同类型的多个试剂中选择有效使用期限最短的试剂作为新的在位试剂。在本发明实施例中，有问题的试剂可以被屏蔽(可以自动屏蔽或用户选择屏蔽)，能避免测试因某个有问题的试剂而中断，可以提升测试速度。
一些实施例中，处理器还用于获取当前使用试剂的状态，若当前使用试剂的状态为异常，则处理器触发试剂遮蔽命令。处理器用于获取当前使用试剂的状态，具体可以包括：处理器根据当前使用试剂的质控数据、使用了当前使用试剂的样本测试数据、用户输入的当前使用试剂的信息中的至少一项，获取当前使用试剂的状态。
在样本分析设备对样本进行测试的过程中，处理器还用于获取当前使用试剂的状态，一旦检测到当前使用试剂的状态异常，则立即触发试剂遮蔽命令。并响应于该试剂遮蔽命令，避开当前使用试剂，使用新的在位试剂继续进行测试，以使当前测试项目能够可靠、准确的进行。
获取当前使用试剂的状态例如可以包括：当前使用试剂的质控数据不满足质控标准，和/或，使用了当前使用试剂的样本测试数据不符合该类型样本的统计学规律，则可以确定当前使用试剂的状态异常；获取用户输入的当前使用试剂状态异常的信息。
为便于用户在对试剂部件12所承载的试剂进行更换、补充时，能够快速、准确的识别试剂遮蔽命令所指向的试剂，提高工作效率，在上述任一实施例的基础上，本实施例提供的样本分析设备还包括试剂状态指示装置，处理器响应于试剂遮蔽命令，控制试剂状态指示装置指示出试剂遮蔽命令所指向的试剂。
在一种可能的实现方式中，试剂状态指示装置可以通过显示屏来实现。处理器响应于试剂遮蔽命令，控制显示屏显示试剂遮蔽命令所指向的试剂的标识信息。
本实施例提供的样本分析设备，通过设置试剂状态指示装置，并响应于试剂遮蔽命令，控制试剂状态指示装置指示出试剂遮蔽命令所指向的试剂，使得用户在对试剂部件所承载的试剂进行更换、补充时，能够快速、准确的识别试剂遮蔽命令所指向的试剂，提高了工作效率。
为了使用户能够方便、直观的查看各个试剂的状态，在上述任一实施例的基础上，本实施提供的样本分析设备还可以包括显示部件，用于在显示部件的显示界面上展示用于表示试剂部件承载的各个试剂状态的状态标识。状态标识例如可以包括用于标识试剂被避开的遮蔽标识、用于标识试剂的遮蔽状态被取消的取消遮蔽标识、用于标识试剂是否过期的标识、用于标识试剂余量是否充足的标识、用于标识试剂是否校准的标识、用于标识试剂是否为无效试剂的标识以及用于标识试剂是否被用光的标识等。
在显示部件的显示界面上可以通过文字、图形、表格等方式展示用于表示试剂部件承载的各个试剂状态的状态标识。图2为一种实施例的显示界面的示意图，图3为另一种实施例的显示界面的示意图。图2和图3中均展示了4种状态标识：试剂遮蔽、无效试剂、试剂过期和余量不足。在实际使用中，可以根据需要包括更多或者更少的状态标识。图2可以用于表示试剂部件为试剂盘时的显示界面，如图2所示，编号1-18可以表示试剂在试剂盘上的位置信息。其中，2号、5号和16号试剂处于遮蔽状态，即它们是试剂遮蔽命令所指向的试剂，在添加试剂时需要避开；6号和10号试剂为无效试剂；1号试剂过期；11号试剂余量不足。图3可以用于表示试剂部件为矩阵式分布试剂架时的显示界面，如图3所示，编号1-1表示试剂在试剂架上位于第一行第一列，编号2-4表示试剂在试剂架上位于第二行第四列，其他编号含义依次类推，此处不再赘述。其中，1-4号、2-2号和3-6号试剂处于遮蔽状态，即它们是试剂遮蔽命令所指向的试剂，在添加试剂时需要避开；3-1号试剂为无效试剂；2-6号试剂过期；3-3号试剂余量不足。
表1为一实施例中在显示部件的显示界面上显示的试剂部件承载的试剂的状态标识表。需要说明的是，受篇幅限制，表1仅展示了试剂部件承载的部分试剂的部分状态标识。本实施例中试剂部件的数量为两个，表1中位置信息1-4表示第一试剂部件的4号位置，2-3表示第二试剂部件的3号位置。试剂编号可以唯一标识试剂，例如可以通过试剂部件的扫描装置扫描试剂容器上的条形码或者二维码等标签获得。进一步的，在表1中还可以通过颜色信息来标识试剂的状态标识，例如对于遮蔽状态的试剂可以使用红色标识，对于余量不足的试剂可以使用黄色标识。
表1
Figure PCTCN2019114746-appb-000001
需要说明的是，本实施例中的显示部件可以通过在样本分析设备上集成显示模块如显示屏幕来实现，也可以是通过有线和/或无线的方式连接一个计算机设备(例如电脑、智能手机等)，通过计算机设备的屏幕显示状态标识来实现，这些都属于本申请显示部件所限定和保护的范围。
一些实施例中，样本分析设备的处理器还可以响应于试剂遮蔽命令，将试剂遮蔽命令所指向的试剂的状态标识中的至少部分修改为遮蔽标识，遮蔽标识用于标识试剂被避开。以表1为例进行说明，当试剂遮蔽命令所指向的试剂包括1-2时，则处理器响应于该试剂遮蔽命令，将1-2号试剂的状态标识中“是否遮蔽”由“否”修改为“是”，即将1-2号试剂状态标识中的一项修改为遮蔽标识，用于标识在试剂添加时避开1-2号试剂。
在样本分析设备对样本进行测试的过程中，用户可以根据样本的统计学规律以及自有经验对测试过程进行监控。在异常情况出现时，为了使用户能够及时干预测试过程，确保测试的有效性和准确性，样本分析设备还提供人机交互装置以便用户可以进行相关操作。例如当用户确定试剂异常时，可以通过鼠标、键盘、触控装置等输入设备，改变试剂的状态标识。与此同时，样本分析设备还可以包括用于检测用户在显示界面上的操作的输入检测部件，输入检测部件例如可以是传感器。样本分析设备可以根据用户在显示界面上的操作，执行相应的处理。当检测到用户将试剂的状态标识中的至少部分修改为遮蔽标识时，输出指向该试剂的试剂遮蔽命令，处理器响应于试剂遮蔽命令，在控制试剂添加机构 添加试剂时避开试剂遮蔽命令所指向的试剂；当检测到用户将试剂的状态标识中的至少部分修改为取消遮蔽标识时，输出指向该试剂的取消遮蔽命令，处理器响应于取消遮蔽命令，控制试剂添加机构停止执行指向该试剂的试剂遮蔽命令。
在一种可能的实现方式中，可以通过试剂设置界面对试剂的状态标识进行修改。首先，可以通过点击、长按等方式选中需要修改状态标识的一个或多个试剂；然后可以通过菜单、按钮等方式进入选中试剂的试剂设置界面。请参照图4A和图4B，图4A和图4B为一种实施例的设置界面的示意图。可以理解的是，当选中的试剂当前未被遮蔽时，其对应的设置界面如图4A所示；当选中的试剂当前的状态标识为遮蔽标识时，其对应的设置界面如图4B所示。需要说明的是，设置界面中还可以包括其他试剂设置选项，由于其他试剂设置选项不涉及本申请的发明点，因此在图4A和图4B中并未展示。
仍以表1为例进行说明：当选中的试剂为1-4时，如表1所示，其“是否遮蔽”一栏对应的状态为“否”，即表示1-4号试剂当前未被遮蔽，因此其对应的设置界面如图4A所示，当用户在该界面中勾选试剂遮蔽这一选项，并点击确定按钮时，样本分析设备的输入检测部件便可以检测到用户将1-4号试剂的状态标识中的至少部分修改为遮蔽标识，因此输出指向1-4号试剂的试剂遮蔽命令。处理器响应于该试剂遮蔽命令，表1中1-4号试剂“是否遮蔽”一栏对应的状态修改为“是”，在控制试剂添加机构添加试剂时避开1-4号试剂。
当选中的试剂为2-3时，如表1所示，其“是否遮蔽”一栏对应的状态为“是”，即表示2-3号试剂当前被遮蔽，其状态标识为遮蔽标识，因此其对应的设置界面如图4B所示，当用户在该界面中勾选取消遮蔽这一选项，并点击确定按钮时，样本分析设备的输入检测部件便可以检测到用户将2-3号试剂的状态标识中的至少部分修改为取消遮蔽标识，因此输出指向2-3号试剂的取消遮蔽命令。处理器响应于该取消遮蔽命令，表1中2-3号试剂“是否遮蔽”一栏对应的状态修改为“否”，控制试剂添加机构停止执行指向2-3试剂的试剂遮蔽命令，即在添加试剂时无需避开2-3号试剂。
以上是针对本发明的样本分析设备的一些说明，本发明一些实施例中还公开样本分析设备的控制方法(以下简称控制方法)，其涉及到的样 本分析设备可以是上文中所公开的样本分析设备。
请参照图5，一实施例的控制方法可以包括：
步骤100、根据当前测试项目控制试剂的吸取。具体的，可以根据当前测试项目控制样本分析设备的试剂添加机构从放置在试剂部件的预设位置上的试剂容器中吸取试剂。
本实施例中例如可以根据当前测试项目确定需要使用的试剂，然后控制样本分析设备的试剂添加机构从相应的试剂容器中吸取试剂。具体的，在确定需要使用的试剂之后，可以通过控制移动试剂部件如转动试剂盘将需要使用的试剂移动至试剂添加机构吸取试剂的位置，或者，可以通过控制移动试剂添加机构如驱动试剂针进行二维或者三维的运动，将试剂添加机构移动至需要使用的试剂所在的位置，以完成试剂的吸取工作。
步骤110、响应于试剂遮蔽命令，避开试剂遮蔽命令所指向的试剂。具体的，响应于试剂遮蔽命令，在控制试剂添加机构添加试剂时避开试剂遮蔽命令所指向的试剂。
本实施例中的试剂遮蔽命令可以包括需要被避开的试剂的标识信息，标识信息例如可以包括试剂在试剂部件上的位置信息、试剂编号等。需要被避开的试剂可以包括异常试剂，如质控结果不达标的试剂、在使用过程中被污染了的试剂等；还可以包括未达到使用条件的试剂，如温度未达到测试所需温度的试剂；还可以包括因其他因素暂时不需要被使用的试剂。试剂遮蔽命令可以指向多个需要被避开的试剂。
本实施例提供的样本分析设备的控制方法，由于能够响应于试剂遮蔽命令，在控制试剂添加机构添加试剂时避开试剂遮蔽命令所指向的试剂，因此在测试过程中，当出现异常试剂时，可以通过将试剂遮蔽命令指向异常试剂来避开异常试剂，无需卸载异常试剂，从而简化了遇到异常试剂时的操作，且无需中断测试，进而能够提高测试效率和用户体验。
一些实施例中，当试剂遮蔽命令所指向的试剂包括在位试剂时，根据预设的试剂选择策略从试剂部件承载的与在位试剂同类型的多个试剂中确定新的在位试剂，并控制试剂添加机构从新的在位试剂中吸取试剂，在位试剂是指从试剂部件承载的同种类型的试剂中确定出的供试剂添加机构吸取的试剂。其中，在位试剂的含义可以参考上述实施例此处不再赘述。根据预设的试剂选择策略从试剂部件承载的与在位试剂同类型的 多个试剂中确定新的在位试剂，具体可以包括：根据试剂的类型以及试剂的余量、有效期和校准状态中的至少一项，从试剂部件承载的与在位试剂同类型的多个试剂中确定新的在位试剂。
可选的，控制方法还可以包括：获取当前使用试剂的状态，若当前使用试剂的状态为异常，则触发试剂遮蔽命令。其中，获取当前使用试剂的状态具体可以用包括：根据当前使用试剂的质控数据、使用了当前使用试剂的样本测试数据、用户输入的当前使用试剂的信息中的至少一项，获取当前使用试剂的状态。
可选的，控制方法还可以包括：响应于试剂遮蔽命令，控制试剂状态指示装置指示出试剂遮蔽命令所指向的试剂。
可选的，控制方法还可以包括：在样本分析设备的显示界面上展示用于表示试剂部件承载的各个试剂状态的状态标识。
可选的，控制方法还可以包括：响应于试剂遮蔽命令，将试剂遮蔽命令所指向的试剂的状态标识中的至少部分修改为遮蔽标识，遮蔽标识用于标识试剂被遮蔽。
可选的，控制方法还可以包括：获取用户输入的第一指令，第一指令用于指示将试剂的状态标识中的至少部分修改为遮蔽标识；
根据第一指令，输出指向该试剂的试剂遮蔽命令。
可选的，控制方法还可以包括：获取用户输入的第二指令，第二指令用于指示将试剂的状态标识中的至少部分修改为取消遮蔽标识；
根据第二指令，输出指向该试剂的取消遮蔽命令，并响应于取消遮蔽命令，控制试剂添加机构停止执行指向该试剂的试剂遮蔽命令。
请参照图6，图6为另一种实施例的样本分析设备的控制方法的流程图。如图6所示，在上述任一实施例的基础上，本实施例提供的控制方法还可以包括：
步骤200、在样本分析设备的显示界面上展示用于表示试剂部件承载的各个试剂状态的状态标识。
步骤210、获取用户在显示界面上输入的指令。用户输入的指令可以包括第一指令和第二指令。其中，第一指令用于指示将试剂的状态标识中的至少部分修改为遮蔽标识，第二指令用于指示将试剂的状态标识中的至少部分修改为取消遮蔽标识。
步骤220、根据用户输入的指令，输出控制命令。控制命令可以包 括试剂遮蔽命令和取消遮蔽命令。具体的，若用户在显示界面上输入的指令为第一指令，则输出指向该试剂的试剂遮蔽命令；若用户在显示界面上输入的指令为第二指令，则输出指向该试剂的取消遮蔽命令。
步骤230、根据控制命令，控制试剂的吸取。具体的，响应于试剂遮蔽命令，在控制试剂添加机构添加试剂时避开试剂遮蔽命令所指向的试剂；响应于取消遮蔽命令，控制试剂添加机构停止执行指向该试剂的试剂遮蔽命令。
本实施例提供的控制方法，通过获取用户在显示界面上输入的指令，并根据用户输入的指令，执行相应的试剂遮蔽命令或者取消遮蔽命令，实现了对用户输入指令的快速响应。
请参照图7，图7为又一种实施例的样本分析设备的控制方法的流程图。如图7所示，本实施例提供的控制方法可以包括：
步骤300、判断当前使用试剂余量是否充足。若余量充足，则继续执行步骤310。对于余量不足的情况，可以参考现有技术的实现方式，此处不再赘述。
步骤310、判断当前使用试剂的状态是否异常，若当前使用试剂的状态异常，则继续执行步骤320。具体的可以根据当前使用试剂的质控数据、使用了当前使用试剂的样本测试数据以及用户输入的当前使用试剂的信息等来判断当前使用试剂的状态是否异常，具体实现方式可以参考上述实施例。对于当前使用试剂的状态正常的情况，可以参考现有技术的实现方式，此处不再赘述。
步骤320、触发试剂遮蔽命令，试剂遮蔽命令指向当前使用试剂。
在当前使用试剂的状态异常时，触发指向当前使用试剂的试剂遮蔽命令。
步骤330、响应于试剂遮蔽命令，在控制试剂添加机构添加试剂时避开当前使用试剂。
步骤340、确定新的待用试剂，并控制试剂添加机构从新的待用试剂中吸取试剂。具体的，可以根据预设的试剂选择策略从试剂部件承载的与当前使用试剂同类型的多个试剂中确定新的待用试剂，并控制试剂添加机构从新的待用试剂中吸取试剂。
本实施例提供的控制方法，在测试过程中，针对余量充足的当前使用试剂，在确定其状态异常时，通过触发指向该试剂的试剂遮蔽命令以 避开该异常试剂，并使用新的待用试剂继续进行测试，不仅简化了测试过程中遇到异常试剂时的操作，而且无需中断测试，提高了测试效率和用户体验。
本发明实施例还提供一种样本分析设备的控制装置，可以包括：用于根据当前测试项目，控制样本分析设备的试剂添加机构，从放置在试剂部件的预设位置上的试剂容器中吸取试剂的模块；用于响应于试剂遮蔽命令，在控制试剂添加机构添加试剂时避开试剂遮蔽命令所指向的试剂的模块。
本文参照了各种示范实施例进行说明。然而，本领域的技术人员将认识到，在不脱离本文范围的情况下，可以对示范性实施例做出改变和修正。例如，各种操作步骤以及用于执行操作步骤的组件，可以根据特定的应用或考虑与系统的操作相关联的任何数量的成本函数以不同的方式实现(例如一个或多个步骤可以被删除、修改或结合到其他步骤中)。
另外，如本领域技术人员所理解的，本文的原理可以反映在计算机可读存储介质上的计算机程序产品中，该可读存储介质预装有计算机可读程序代码。任何有形的、非暂时性的计算机可读存储介质皆可被使用，包括磁存储设备(硬盘、软盘等)、光学存储设备(CD-ROM、DVD、Blu Ray盘等)、闪存和/或诸如此类。这些计算机程序指令可被加载到通用计算机、专用计算机或其他可编程数据处理设备上以形成机器，使得这些在计算机上或其他可编程数据处理装置上执行的指令可以生成实现指定的功能的装置。这些计算机程序指令也可以存储在计算机可读存储器中，该计算机可读存储器可以指示计算机或其他可编程数据处理设备以特定的方式运行，这样存储在计算机可读存储器中的指令就可以形成一件制造品，包括实现指定功能的实现装置。计算机程序指令也可以加载到计算机或其他可编程数据处理设备上，从而在计算机或其他可编程设备上执行一系列操作步骤以产生一个计算机实现的进程，使得在计算机或其他可编程设备上执行的指令可以提供用于实现指定功能的步骤。
虽然在各种实施例中已经示出了本文的原理，但是许多特别适用于特定环境和操作要求的结构、布置、比例、元件、材料和部件的修改可以在不脱离本披露的原则和范围内使用。以上修改和其他改变或修正将被包含在本文的范围之内。
前述具体说明已参照各种实施例进行了描述。然而，本领域技术人 员将认识到，可以在不脱离本披露的范围的情况下进行各种修正和改变。因此，对于本披露的考虑将是说明性的而非限制性的意义上的，并且所有这些修改都将被包含在其范围内。同样，有关于各种实施例的优点、其他优点和问题的解决方案已如上所述。然而，益处、优点、问题的解决方案以及任何能产生这些的要素，或使其变得更明确的解决方案都不应被解释为关键的、必需的或必要的。本文中所用的术语“包括”和其任何其他变体，皆属于非排他性包含，这样包括要素列表的过程、方法、文章或设备不仅包括这些要素，还包括未明确列出的或不属于该过程、方法、系统、文章或设备的其他要素。此外，本文中所使用的术语“耦合”和其任何其他变体都是指物理连接、电连接、磁连接、光连接、通信连接、功能连接和/或任何其他连接。
具有本领域技术的人将认识到，在不脱离本发明的基本原理的情况下，可以对上述实施例的细节进行许多改变。因此，本发明的范围应根据以下权利要求确定。

Claims (22)

  1. 一种样本分析设备，其特征在于，包括：
    样本部件，用于承载容纳有样本的样本容器；
    样本添加机构，用于从放置在样本部件处的待测样本容器中吸取样本，并将吸取的样本排放到待加样的反应容器中；
    试剂部件，包括多个试剂放置位，用于承载多个试剂容器，所述试剂容器用于容纳试剂；
    试剂添加机构，用于从放置在试剂部件的预设位置上的试剂容器中吸取试剂，并将吸取的试剂排放到待加试剂的反应容器中；以及
    处理器，至少用于根据当前测试项目控制样本添加机构进行样本的添加，以及控制试剂添加机构从放置在试剂部件的预设位置上的试剂容器中吸取试剂，并响应于试剂遮蔽命令，在控制所述试剂添加机构添加试剂时避开所述试剂遮蔽命令所指向的试剂。
  2. 如权利要求1所述的设备，其特征在于，当所述试剂遮蔽命令所指向的试剂包括在位试剂时，所述处理器还根据预设的试剂选择策略从所述试剂部件承载的与所述在位试剂同类型的多个试剂中确定新的在位试剂，并控制所述试剂添加机构从所述新的在位试剂中吸取试剂，所述在位试剂是指从所述试剂部件承载的同种类型的试剂中确定出的供试剂添加机构吸取的试剂。
  3. 如权利要求2所述的设备，其特征在于，所述处理器根据预设的试剂选择策略从所述试剂部件承载的与所述在位试剂同类型的多个试剂中确定新的在位试剂，包括：
    所述处理器根据试剂的类型以及试剂的余量、有效期和校准状态中的至少一项，从所述试剂部件承载的与所述在位试剂同类型的多个试剂中确定新的在位试剂。
  4. 如权利要求1所述的设备，其特征在于，所述处理器还用于获取当前使用试剂的状态，若当前使用试剂的状态为异常，则所述处理器触发试剂遮蔽命令。
  5. 如权利要求4所述的设备，其特征在于，所述处理器用于获取当前使用试剂的状态，包括：
    所述处理器根据所述当前使用试剂的质控数据、使用了所述当前使用试剂的样本测试数据、用户输入的所述当前使用试剂的信息中的至少 一项，获取所述当前使用试剂的状态。
  6. 如权利要求1至5中任一项所述的设备，其特征在于，还包括试剂状态指示装置，所述处理器响应于试剂遮蔽命令，控制所述试剂状态指示装置指示出所述试剂遮蔽命令所指向的试剂。
  7. 如权利要求1至5中任一项所述的设备，其特征在于，还包括显示部件，用于在显示部件的显示界面上展示用于表示所述试剂部件承载的各个试剂状态的状态标识。
  8. 如权利要求7所述的设备，其特征在于，所述处理器响应于试剂遮蔽命令，将所述试剂遮蔽命令所指向的试剂的状态标识中的至少部分修改为遮蔽标识，所述遮蔽标识用于标识试剂被避开。
  9. 如权利要求7所述的设备，其特征在于，还包括输入检测部件，所述输入检测部件用于检测用户在显示界面上的操作，当检测到用户将试剂的状态标识中的至少部分修改为遮蔽标识时，输出指向该试剂的试剂遮蔽命令。
  10. 如权利要求9所述的设备，其特征在于，所述输入检测部件在检测到用户将试剂的状态标识中的至少部分修改为取消遮蔽标识时，输出指向该试剂的取消遮蔽命令，所述处理器响应于取消遮蔽命令，控制所述试剂添加机构停止执行指向该试剂的试剂遮蔽命令。
  11. 一种样本分析设备的控制方法，其特征在于，包括：
    根据当前测试项目控制所述样本分析设备的试剂添加机构从放置在试剂部件的预设位置上的试剂容器中吸取试剂；
    响应于试剂遮蔽命令，在控制所述试剂添加机构添加试剂时避开所述试剂遮蔽命令所指向的试剂。
  12. 如权利要求11所述的方法，其特征在于，当所述试剂遮蔽命令所指向的试剂包括在位试剂时，根据预设的试剂选择策略从所述试剂部件承载的与所述在位试剂同类型的多个试剂中确定新的在位试剂，并控制所述试剂添加机构从所述新的在位试剂中吸取试剂，所述在位试剂是指从所述试剂部件承载的同种类型的试剂中确定出的供试剂添加机构吸取的试剂。
  13. 如权利要求12所述的方法，其特征在于，所述根据预设的试剂选择策略从所述试剂部件承载的与所述在位试剂同类型的多个试剂中确定新的在位试剂，包括：
    根据试剂的类型以及试剂的余量、有效期和校准状态中的至少一项，从所述试剂部件承载的与所述在位试剂同类型的多个试剂中确定新的在位试剂。
  14. 如权利要求11所述的方法，其特征在于，还包括：
    获取当前使用试剂的状态，若当前使用试剂的状态为异常，则触发试剂遮蔽命令。
  15. 如权利要求14所述的方法，其特征在于，所述获取当前使用试剂的状态，包括：
    根据所述当前使用试剂的质控数据、使用了所述当前使用试剂的样本测试数据、用户输入的所述当前使用试剂的信息中的至少一项，获取所述当前使用试剂的状态。
  16. 如权利要求11至15中任一项所述的方法，其特征在于，还包括：
    响应于试剂遮蔽命令，控制试剂状态指示装置指示出所述试剂遮蔽命令所指向的试剂。
  17. 如权利要求11至15中任一项所述的方法，其特征在于，还包括：
    在所述样本分析设备的显示界面上展示用于表示所述试剂部件承载的各个试剂状态的状态标识。
  18. 如权利要求17所述的方法，其特征在于，还包括：
    响应于试剂遮蔽命令，将所述试剂遮蔽命令所指向的试剂的状态标识中的至少部分修改为遮蔽标识，所述遮蔽标识用于标识试剂被遮蔽。
  19. 如权利要求17所述的方法，其特征在于，还包括：
    获取用户输入的第一指令，所述第一指令用于指示将试剂的状态标识中的至少部分修改为遮蔽标识；
    根据所述第一指令，输出指向该试剂的试剂遮蔽命令。
  20. 如权利要求17所述的方法，其特征在于，还包括：
    获取用户输入的第二指令，所述第二指令用于指示将试剂的状态标识中的至少部分修改为取消遮蔽标识；
    根据所述第二指令，输出指向该试剂的取消遮蔽命令，并响应于所述取消遮蔽命令，控制所述试剂添加机构停止执行指向该试剂的试剂遮蔽命令。
  21. 一种样本分析设备的控制装置，其特征在于，包括：
    用于根据当前测试项目，控制所述样本分析设备的试剂添加机构，从放置在试剂部件的预设位置上的试剂容器中吸取试剂的模块；
    用于响应于试剂遮蔽命令，在控制所述试剂添加机构添加试剂时避开所述试剂遮蔽命令所指向的试剂的模块。
  22. 一种计算机可读存储介质，其特征在于，包括程序，所述程序能够被处理器执行以实现如权利要求11-20中任一项所述的方法。
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CN1148177A (zh) * 1995-03-17 1997-04-23 株式会社日立制作所 自动分析装置
CN1153305A (zh) * 1995-07-11 1997-07-02 株式会社日立制作所 试剂管理方法和装置
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JP2012251909A (ja) * 2011-06-03 2012-12-20 Hitachi High-Technologies Corp 自動分析装置
CN107290560A (zh) * 2016-04-05 2017-10-24 深圳迈瑞生物医疗电子股份有限公司 用于多瓶试剂的试剂吸取方法、装置和样本分析仪

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CN1148177A (zh) * 1995-03-17 1997-04-23 株式会社日立制作所 自动分析装置
CN1153305A (zh) * 1995-07-11 1997-07-02 株式会社日立制作所 试剂管理方法和装置
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