WO2021078236A1 - 一种协同杀虫杀螨组合物 - Google Patents

一种协同杀虫杀螨组合物 Download PDF

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WO2021078236A1
WO2021078236A1 PCT/CN2020/123112 CN2020123112W WO2021078236A1 WO 2021078236 A1 WO2021078236 A1 WO 2021078236A1 CN 2020123112 W CN2020123112 W CN 2020123112W WO 2021078236 A1 WO2021078236 A1 WO 2021078236A1
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active component
compound
composition
composition according
active
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PCT/CN2020/123112
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English (en)
French (fr)
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班兰凤
宋玉泉
刘少武
常秀辉
张俊龙
范晓溪
吴鸿飞
于海波
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沈阳中化农药化工研发有限公司
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Priority claimed from CN201911021378.9A external-priority patent/CN112704075A/zh
Priority claimed from CN201911021377.4A external-priority patent/CN112704070B/zh
Application filed by 沈阳中化农药化工研发有限公司 filed Critical 沈阳中化农药化工研发有限公司
Publication of WO2021078236A1 publication Critical patent/WO2021078236A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing within the same carbon skeleton a carboxylic group or a thio analogue, or a derivative thereof, and a carbon atom having only two bonds to hetero atoms with at the most one bond to halogen, e.g. keto-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/10—Sulfones; Sulfoxides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof

Definitions

  • the invention belongs to the field of insecticides and acaricides, and relates to a synergistic insecticidal and acaricidal composition and its application.
  • Insecticides and acaricides have obvious effects in the prevention and control of agricultural and forestry pests or urban sanitation pests.
  • Cipheral patent CN105541682 discloses a biphenyl compound and its use in controlling insect pests and mites.
  • Compound 1 (hereinafter referred to as compound I) can be used to control a variety of pests and mites, especially having outstanding control effects on pest mites. .
  • Insecticides and acaricides containing a single active component are used continuously in pest control, which can easily make pests resistant to pesticides.
  • By mixing two active components of insecticide and acaricide in a certain proportion to form a mixed component it can often improve the control effect, reduce the amount of active ingredients, save costs, and at the same time can delay the occurrence of pest resistance.
  • the purpose of the present invention is to provide a synergistic insecticidal and acaricidal composition in order to meet the demand for increasing effects of insecticides and acaricides and continuous renewal of varieties in the prevention and control of pests in the fields of agriculture, forestry and urban hygiene.
  • a synergistic insecticidal and acaricide composition is active component A and active component B, wherein the weight ratio between active component A and active component B is 1:99-99:1;
  • the active component A is selected from compound I, and the active component B is selected from fluazinam, bifenazid, tarfenac, Pyflubumider, Acynonspy, pyrethroid insecticides or pyrethroid acaricides;
  • the structure of the active component A compound I is as follows:
  • the active component B is selected from fenpropathrin, lambda-cyfluthrin, cyfluthrin, cyhalothrin, permethrin, Heptafluthrin, Momfluorothrin or cypermethrin.
  • the active component A is compound I, and the active component B is selected from fenpropathrin, lambda-cyfluthrin, cyfluthrin, cyhalothrin, permethrin, Heptafluthrin, Momfluorothrin or cypermethrin; the weight of the two active components The ratio of copies is 40:1-1:40.
  • the active component A is compound I, and the active component B is selected from fenpropathrin or lambda-cyfluthrin; the weight ratio of the two active components is 20:1 to 1:20.
  • the active component A is compound I, and the active component B is selected from fenpropathrin or lambda-cyfluthrin; the weight ratio of the two active components is 10:1 to 1:10.
  • the active component A is compound I, and the active component B is selected from fenpropathrin or lambda-cyfluthrin; the weight ratio of the two active components is 5:1 to 1:5.
  • the active component A is compound I, and the active component B is selected from fluazinam, bifenazate, or tebufenpyr; wherein, the weight ratio between the active component A and the active component B is 50:1 -1:40.
  • the active component A is compound I, and the active component B is selected from Pyflubumider or Acynonspy; wherein, the weight ratio between the active component A and the active component B is 40:1 to 1:40.
  • the active component A is compound I, and the active component B is selected from fluazinam, bifenazid, tarfenac, Pyflubumider or Acynonspy; wherein, the weight ratio between the active component A and the active component B It is 10:1-1:10.
  • the active component A is compound I, and the active component B is selected from fluazinam, Pyflubumider or Acynonspy; wherein the weight ratio between the active component A and the active component B is 5:1 to 1:5.
  • the active component A is compound I, and the active component B is bifenazate; wherein the weight ratio between the active component A and the active component B is 4:1-1:6.
  • the composition is applied to the pests or their growth medium to be controlled.
  • composition of the present invention is particularly suitable for controlling a variety of important agricultural pests.
  • the present invention also includes the use of the composition of the present invention to control agricultural and forestry pests or urban sanitary pests by preparing insecticidal and acaricidal formulations.
  • the prepared insecticidal and acaricidal agent is applied to the pests to be controlled or the growth medium thereof based on an effective dose.
  • the most suitable effective dose is usually selected from 10 grams to 500 grams per hectare, and the effective dose is preferably from 15 grams to 100 grams per hectare.
  • a synergistic insecticidal and acaricidal preparation is prepared by mixing the composition as an active ingredient with a carrier and any auxiliary agent to prepare a preparation.
  • the cumulative content of the composition in the formulation is between 0.5 wt% and 95 wt%.
  • the cumulative content of the active ingredient in the formulation is between 1% and 85%.
  • composition of the present invention exhibits a significant synergistic effect on insecticide and acaricide within a certain ratio range, and improves the control effect of a single active ingredient compound in the composition on pests.
  • the dosage of the composition of the present invention applied to insecticide and acaricide is significantly lower than the dosage of a single compound in the composition, thereby reducing the cost of use and reducing environmental pollution.
  • the active ingredients in the composition of the present invention have different mechanisms of action in killing insects and mites, and there is no problem of cross-resistance. Using them to control pests can delay the occurrence of pest resistance and improve the resistance of resistant populations. Control effect.
  • composition of the present invention has improved broad-spectrum properties relative to each single agent, but the synergistic effect is not linearly related to the single agent.
  • Example 1 Determination of the synergistic effect of the composition containing compound I on Tetranychus cinnabarinus
  • Test subjects Tetranychus cinnabarinus Boisduval, adult mites, sensitive strains raised indoors.
  • Liquid medicine preparation According to different test needs, use an electronic analytical balance to accurately weigh the test samples (different proportions of the composition and the original drug of the present invention). The original drug is dissolved in acetone, and then 0.1% Tween 80 water is used according to The designed dose of the experiment was diluted to a certain concentration of liquid medicine.
  • Test method The potted seedling spray method was used to determine the activity against adult Tetranychus cinnabarinus. First, 40-60 adult mites of Tetranychus cinnabarinus of the same size are connected to the bean seedlings (leave one true leaf) in the first pair of true leaf flattening stage, and the base number is counted after the adult mites are stabilized; then the airbrush method is used to treat the test with liquid medicine. Wood, 1.5mL per plant, set a blank control.
  • P m is the death rate (%) of the target when the concentration of the first active component is m
  • P n is the death rate (%) of the target when the concentration of the second active component is n.
  • the two active components mixed at the set concentration have a synergistic effect, otherwise it is an antagonistic effect.
  • Example 2 Indoor activity determination of the composition containing compound I against Tetranychus cinnabarinus
  • the composition of compound I of the present invention mixed with 5 agents such as fluazinam has a significant synergistic effect on adult Tetranychus cinnabarinus mites.
  • compound I and fluazinam, Pyflubumider or Acynonspy were used for testing 5:1-1:5 composition; compound I and bifenazate to test 4:1-1:6 composition composition and then use Sun yp method for indoor activity determination.
  • Test target Tetranychus cinnabarinus Boisduval adult mites, a sensitive strain raised indoors.
  • Liquid medicine preparation According to different test needs, use an electronic analytical balance to accurately weigh the test samples. Among them, the original drug is dissolved in acetone, and then diluted with 0.1% Tween 80 water according to the designed dose of the test to form a series of drugs with a certain concentration gradient liquid.
  • Test method The potted seedling spray method was used to determine the activity against adult Tetranychus cinnabarinus. First, the adult mites of Tetranychus cinnabarinus of the same size are connected to the bean seedlings (leave one true leaf) in the first pair of true leaf flattening stage, and the base number is counted after the adult mites are stabilized; then the liquid is sprayed with Airbrush according to the experimental design. Spray evenly from dose to high dose, 1.5 mL per plant, 4 repetitions for each treatment, and a blank control.
  • CTC value The co-toxicity coefficient (CTC value) of the mixture is calculated according to the following formula:
  • TTI TIA ⁇ PA+TIB ⁇ PB
  • TTI-theoretical toxicity index of the mixture TIA-A drug toxicity index; the percentage content of PA-A drug in the mixture; TIB-B drug toxicity index; the PB-B drug in the mixture Percentage content.
  • CTC co-toxicity coefficient
  • LC 50 value of the composition is less than the LC 50 wherein a single dose or two, it means that achieve the same effect (mortality 50%), dosage composition is less than one or two single dose The dosage used.
  • the LC 50 value of compound I ⁇ fluazinam ratio 1 to Tetranychus cinnabarinus is 0.48 mg/L, and the single-dose LC 50 values are 0.52 mg/L and 156.40 mg/L, respectively, which means that the same effect is achieved.
  • the dosage of the composition (0.48mg/L) is less than the dosage of one or two single doses (0.52mg/L and 156.40mg/L); in addition, from the co-toxicity coefficient
  • the control effect of the composition is also higher than the theoretical effect of the two single doses in varying degrees; since the field dose is positively correlated with the indoor LC 50 value, the field dose of the composition will be reduced accordingly, thereby reducing the use cost and reducing Environmental pollution.
  • Example 3 Determination of the synergistic effect of the composition containing compound I on Tetranychus cinnabarinus
  • Test subjects Tetranychus cinnabarinus Boisduval, adult mites, sensitive strains raised indoors.
  • Liquid medicine preparation According to different test needs, use an electronic analytical balance to accurately weigh the test samples (different proportions of the composition and the original drug of the present invention), where the original drug is dissolved in acetone, and then 0.1% Tween 80 water is used to The designed dose of the experiment was diluted to a certain concentration of liquid medicine.
  • Test method The potted seedling spray method was used to determine the activity against adult Tetranychus cinnabarinus. First, 40-60 adult mites of Tetranychus cinnabarinus of the same size are connected to the bean seedlings (leave one true leaf) in the first pair of true leaf flattening stage, and the base number is counted after the adult mites are stabilized; then the airbrush method is used to treat the test with liquid medicine. Wood, 1.5mL per plant, set a blank control.
  • P m is the death rate (%) of the target when the concentration of the first active component is m
  • P n is the death rate (%) of the target when the concentration of the second active component is n.
  • the two active components mixed at the set concentration have a synergistic effect, otherwise it is an antagonistic effect.
  • Example 4 Indoor activity determination of the composition containing compound I against Tetranychus cinnabarinus
  • composition of the compound I of the present invention mixed with two medicaments such as fenpropathrin has a significant synergistic effect on the adult mites of Tetranychus cinnabarinus.
  • compound I and fenpropathrin were used for test 5: The composition composed of 1-1:5 was then tested for indoor activity by Sun yp method.
  • Test target Tetranychus cinnabarinus Boisduval adult mites, a sensitive strain raised indoors.
  • Liquid medicine preparation According to different test needs, use an electronic analytical balance to accurately weigh the test samples. Among them, the original drug is dissolved in acetone, and then diluted with 0.1% Tween 80 water according to the test design dose to form a series of drugs with a certain concentration gradient liquid.
  • Test method The potted seedling spray method was used to determine the activity against adult Tetranychus cinnabarinus. First, the adult mites of Tetranychus cinnabarinus of the same size are connected to the bean seedlings (leave one true leaf) in the first pair of true leaf flattening stage, and the base number is counted after the adult mites are stabilized; then the liquid is sprayed with Airbrush according to the experimental design. Spray evenly from dose to high dose, 1.5 mL per plant, 4 repetitions for each treatment, and a blank control.
  • CTC value The co-toxicity coefficient (CTC value) of the mixture is calculated according to the following formula:
  • TTI TIA ⁇ PA+TIB ⁇ PB
  • TTI-theoretical toxicity index of the mixture TIA-A drug toxicity index; the percentage of PA-A drug in the mixture; TIB-B drug toxicity index; the PB-B drug in the mixture Percentage content.
  • CTC co-toxicity coefficient
  • LC 50 value of the composition is less than the LC 50 wherein a single dose or two, it means that achieve the same effect (mortality 50%), dosage composition is less than one or two single dose The dosage used.
  • the dosage of the composition (0.43mg/L) is less than the dosage of one or two single doses (0.46mg/L and 5.12mg/L); in addition, from the co-toxicity coefficient
  • the control effect of the composition is also higher than the theoretical effect of the two single doses to varying degrees; since the field dose and the indoor LC 50 value are positively correlated, the field dose of the composition will be reduced accordingly, thereby reducing the cost of use. reduce environmental pollution.

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

本发明属于杀虫杀螨剂领域，涉及一种协同杀虫杀螨组合物。组合物含有活性组分A和活性组分B，活性组分A和活性组分B之间的重量份数比为1:99～99:1；活性组分A选自化合物Ⅰ，活性组分B选自氟啶胺、联苯肼酯、虫螨腈、Pyflubumider、Acynonspy、拟除虫菊酯类杀虫剂或拟除虫菊酯类杀螨剂；所述活性组分A结构如下，本发明的组合物具有增效明显、延缓抗性等优点，可用于防治多种害虫。

Description

一种协同杀虫杀螨组合物 技术领域
本发明属于杀虫杀螨剂领域，涉及一种协同杀虫杀螨组合物及其应用。
背景技术
杀虫杀螨剂在防治农林害虫或城市卫生害虫方面具有明显的作用。
中国发明专利CN105541682公开了一种联苯类化合物及其控制虫害和螨害的用途，其中化合物1(以下简称化合物Ⅰ)可用于防治多种害虫、害螨，尤其对害螨具有突出的防治效果。
含有单一活性组分的杀虫杀螨剂，在害虫防治上连续使用，容易使害虫产生抗药性。通过两种活性组分的杀虫杀螨剂按一定比例混配成混合组分，往往可以提高防效，减少有效成分的用量，节约成本，同时可以延缓害虫抗药性的产生。
尽管现有技术中泛泛公开记载了含化合物Ⅰ的杀虫杀螨剂组合物，但记载的组合物在扩大杀虫谱上与其他组合物的侧重有所不同，并不能达到广谱性，同时其效果也不能相应的预期得到。
发明内容
本发明目的在于为了满足农林和城市卫生领域防治害虫方面对杀虫杀螨剂效果日渐提高和品种不断更新的需求，提供一种协同杀虫杀螨组合物。
为实现上述目的，本发明采用的技术方案为：
一种协同杀虫杀螨组合物，组合物为活性组分A和活性组分B，其中，活性组分A和活性组分B之间的重量份数比为1:99～99:1；活性组分A选自化合物Ⅰ，活性组分B选自氟啶胺、联苯肼酯、虫螨腈、Pyflubumider、Acynonspy、拟除虫菊酯类杀虫剂或拟除虫菊酯类杀螨剂；
所述活性组分A化合物Ⅰ结构如下：
Figure PCTCN2020123112-appb-000001
所述活性组分B选自甲氰菊酯、高效氟氯氰菊酯、氟氯氰菊酯、氯氟氰菊酯、氯菊酯、Heptafluthrin、Momfluorothrin或氯氰菊酯。
所述活性组分A为化合物Ⅰ，活性组分B选甲氰菊酯、高效氟氯氰菊酯、氟氯氰菊酯、氯氟氰菊酯、氯菊酯、Heptafluthrin、Momfluorothrin或氯氰菊酯；两种活性组分的重量份数比为40:1-1:40。
所述活性组分A为化合物Ⅰ，活性组分B选甲氰菊酯或高效氟氯氰菊酯；两种活性组分重量份数比为20:1-1:20。
所述活性组分A为化合物Ⅰ，活性组分B选甲氰菊酯或高效氟氯氰菊酯；两种活性组分重量份数比为10:1-1:10。
所述活性组分A为化合物Ⅰ，活性组分B选甲氰菊酯或高效氟氯氰菊酯；两种活性组分重量份数比为5:1-1:5。
所述活性组分A为化合物Ⅰ，活性组分B选氟啶胺、联苯肼酯或虫螨腈；其中，活性组分A和活性组分B之间的重量份数比为50:1-1:40。
所述活性组分A为化合物Ⅰ，活性组分B选Pyflubumider或Acynonspy；其中，活性组分A和活性组分B之间的重量份数比为40:1-1:40。
所述活性组分A为化合物Ⅰ，活性组分B选氟啶胺、联苯肼酯、虫螨腈、Pyflubumider或Acynonspy；其中，活性组分A和活性组分B之间的重量份数比为10:1-1:10。
所述活性组分A为化合物Ⅰ，活性组分B选氟啶胺、Pyflubumider或Acynonspy；其中，活性组分A和活性组分B之间的重量份数比为5:1-1:5。
所述活性组分A为化合物Ⅰ，活性组分B选联苯肼酯；其中，活性组分A和活性组分B之间的重量份数比为4:1-1:6。
一种协同杀虫杀螨组合物的应用，所述组合物在用于制备控制农业害虫或城市卫生害虫的杀虫杀螨剂中的应用。
以有效剂量计，将所述组合物施于需要控制的害虫或其生长的介质上。
本发明的组合物具体适合于防治多种重要的农业害虫如本发明还包括本发明组合物制备成杀虫杀螨制剂控制农林害虫或城市卫生害虫的用途。具体适合于防治多种重要的农业害虫如粘虫、甜菜夜蛾、棉铃虫、地老虎、甘蓝夜蛾、苹果卷叶蛾、稻纵卷叶螟、玉米螟、二化螟、小菜蛾、菜青虫、美国白蛾、天幕毛虫、舞毒蛾、东亚飞蝗、地下害虫、潜叶蛾、斑潜蝇、蚜虫、叶蝉、花卉介壳虫、马铃薯甲虫、跳甲、蓟马、盲蝽、朱砂叶螨、山楂叶螨、柑橘全爪螨、柑橘锈螨、苹果叶螨、二斑叶螨、瘿螨、粉螨等，城市害虫如白蚁、蜚蠊、蚂蚁、蝇类、蚊类等。用于果树如苹果、梨、柑桔、荔枝等，禾谷类如小麦、水稻等，豆类如大豆、菜豆等，棉花，蔬菜如甘蓝、花椰菜、白菜、油菜、番茄、辣椒以及花卉。用于防治城市害虫时，可以用于家庭、各种公共场所、办公场所，以及发生白蚁危害的树木、堤坝等。
进一步的说，一种协同杀虫杀螨组合物的使用方法，以有效剂量计，将制备的杀虫杀螨剂施于需要控制的害虫或其生长的介质上。通 常选择的较为适宜有效剂量为每公顷10克到500克，优选有效剂量为每公顷15克到100克。
一种协同杀虫杀螨制剂，以所述组合物作为活性成分与载体和任意一种助剂混合，制成制剂。
所述制剂中组合物的累积含量为0.5wt％-95wt％之间。优选，所述制剂中活性组分的累积含量在1％-85％之间。
本发明具有如下优点：
1.本发明的组合物在一定配比范围内对于杀虫杀螨表现出明显的增效作用，提高了组合物中单一活性成分化合物对害虫的防治效果。
2.本发明组合物在应用于杀虫杀螨中的使用剂量明显低于组合物中单一化合物的使用剂量，从而降低使用成本，减少环境污染。
3.本发明组合物中各有效成分在作用于杀虫和杀螨中的作用机理不同，不存在交互抗性的问题，用其防治害虫可以延缓害虫抗药性的发生，并且提高对抗性种群的防治效果。
4.本发明组合物相对于各单剂完善了广谱性，但增效效果并不是与单剂线性相关。
具体实施方式
以下具体实施例用于进一步详细说明本发明，但本发明绝非仅限于这些例子。实施例中各组分配比均以重量计。
室内生物活性测定
实施例1含有化合物Ⅰ的组合物对朱砂叶螨的协同作用测定
供试对象：朱砂叶螨(Tetranychus cinnabarinus Boisduval)，成螨，室内饲养的敏感品系。
测试条件：温度：24～26℃，相对湿度：60％，光照：L:D＝14:10
药液配制：根据不同试验需要，用电子分析天平分别准确称取供试样品(本发明不同配比组合物和原药)，其中，原药以丙酮溶解，再用0.1％吐温80水按照试验设计剂量稀释成具一定浓度的药液。
试验方法：采用盆栽幼苗喷雾法测定对朱砂叶螨成螨的活性大小。首先将40-60头大小一致的朱砂叶螨成螨接到处于第一对真叶平展期的菜豆幼苗(留一片真叶)上，待成螨稳定后计数基数；然后采用Airbrush法用药液处理试材，每株1.5mL，设空白对照。
自然阴干后，将处理后的试材置于观察室内，观察室温度、湿度、光照按需可调节，72h后调查活螨数，计算死亡率。评价采用Bliss法，该方法是评价混剂作用的经典方法之一。Bliss根据其提出的独立联合作用概念认为，杀虫杀螨剂混用时的理论死亡率P可用下式来计算：
P＝P m+P n(1-P m)
P m为第一活性组分在浓度为m时靶标的死亡率(％)；P n为第二活性组分使用浓度为n时靶标的死亡率(％)。
如果两种活性组分在以一定浓度混合后靶标的实际死亡率大于理论死亡率P，则判定两种活性组分在设定浓度下混合使用具有增效作用，反之则为拮抗作用。
结果见表1。
表1化合物Ⅰ与氟啶胺等5个药剂混合使用对朱砂叶螨成螨的协同作用测定
Figure PCTCN2020123112-appb-000002
Figure PCTCN2020123112-appb-000003
实施例2含有化合物Ⅰ的组合物对朱砂叶螨的室内活性测定
由上述协同作用测定效果数据可见本发明化合物Ⅰ与氟啶胺等5个药剂混合的组合物对朱砂叶螨成螨具有明显的增效效果，进一步以化合物Ⅰ和氟啶胺、Pyflubumider或Acynonspy以供试5:1-1:5组成的组合物；化合物Ⅰ和联苯肼酯以供试4:1-1:6组成的组合物再用孙云沛(Sun y-p)法进行室内活性测定。
供试靶标：朱砂叶螨(Tetranychus cinnabarinus Boisduval)成螨，室内饲养的敏感品系。
药液配制：根据不同试验需要，用电子分析天平分别准确称取供试样品，其中，原药以丙酮溶解，再用0.1％吐温80水按照试验设计剂量稀释成具一定浓度梯度的系列药液。
试验方法：采用盆栽幼苗喷雾法测定对朱砂叶螨成螨的活性大小。首先将大小一致的朱砂叶螨成螨接到处于第一对真叶平展期的菜豆幼苗(留一片真叶)上，待成螨稳定后计数基数；然后将药液采用Airbrush喷雾法按试验设计从低剂量到高剂量的顺序均匀喷雾，每株1.5mL，每处理4次重复，另设空白对照。
将处理后的试材置于观察室内，观察室的温度、湿度、光照按需可调节。72小时后调查死、活螨数。用abbott公式计算校正死亡率，用DPS数据处理软件进行统计分析，求出各供试单剂及各不同配比混用的毒力回归方程式、LC 50值及95％置信限，再用孙云沛(Sun y-p)法计算各配比的共毒系数，评价混用效果。
混剂的共毒系数(CTC值)按下列公式计算：
Figure PCTCN2020123112-appb-000004
式中：ATI-混剂实测毒力指数；S-标准药剂的LC 50值；M-混剂的LC 50值。
TTI＝TIA×PA+TIB×PB
式中：TTI-混剂理论毒力指数；TIA-A药剂毒力指数；PA-A药剂在混剂中的百分含量；TIB-B药剂毒力指数；PB-B药剂在混剂中的百分含量。
Figure PCTCN2020123112-appb-000005
式中：CTC-共毒系数；ATI-混剂实测毒力指数；TTI-混剂理论毒力指数。
复配剂的共毒系数(CTC)：CTC≥120表现为增效作用；CTC≤80表现为拮抗作用；80<CTC<120表现为相加作用。
且，组合物的LC 50值小于其中一个或两个单剂的LC 50值，则意味着在达到相同效果(死亡率为50％)时，组合物的使用剂量小于其中一个或两个单剂的使用剂量。
以试验结果见表2-5。
表2：化合物Ⅰ·氟啶胺对朱砂叶螨室内联合毒力测定结果
Figure PCTCN2020123112-appb-000006
表3：化合物Ⅰ·联苯肼酯对朱砂叶螨室内联合毒力测定结果
Figure PCTCN2020123112-appb-000007
表4：化合物Ⅰ·Pyflubumide对朱砂叶螨室内联合毒力测定结果
Figure PCTCN2020123112-appb-000008
表5：化合物Ⅰ·Acynonspyr对朱砂叶螨室内联合毒力测定结果
Figure PCTCN2020123112-appb-000009
由上述数据可见化合物Ⅰ·氟啶胺配比1对朱砂叶螨LC 50值为0.48mg/L，单剂LC 50值分别为0.52mg/L和156.40mg/L，则意味着在达到相同效果(死亡率为50％)时，组合物的使用剂量(0.48mg/L)小于其中一个或两个单剂的使用剂量(0.52mg/L和156.40mg/L)；另，从共毒系数的定义看，组合物的防治效果也不同程度的高于两种单剂的理论效果；由于田间使用剂量和室内LC 50值正相关，因此组合物田间使用剂量会相应降低，从而降低使用成本，减少环境污染。
实施例3含有化合物Ⅰ的组合物对朱砂叶螨的协同作用测定
供试对象：朱砂叶螨(Tetranychus cinnabarinus Boisduval)，成螨，室内饲养的敏感品系。
测试条件：温度：24～26℃，相对湿度：60％，光照：L:D＝14:10
药液配制：根据不同试验需要，用电子分析天平分别准确称取供试样品(本发明不同配比组合物和原药)，其中，原药以丙酮溶解，再用0.1％吐温80水按照试验设计剂量稀释成具一定浓度的药液。
试验方法：采用盆栽幼苗喷雾法测定对朱砂叶螨成螨的活性大小。首先将40-60头大小一致的朱砂叶螨成螨接到处于第一对真叶平展期的菜豆幼苗(留一片真叶)上，待成螨稳定后计数基数；然后采用Airbrush法用药液处理试材，每株1.5mL，设空白对照。
自然阴干后，将处理后的试材置于观察室内，观察室温度、湿度、光照按需可调节，72h后调查活螨数，计算死亡率。评价采用Bliss法，该方法是评价混剂作用的经典方法之一。Bliss根据其提出的独立联合作用概念认为，杀虫杀螨剂混用时的理论死亡率P可用下式来计算：
P＝P m+P n(1-P m)
P m为第一活性组分在浓度为m时靶标的死亡率(％)；P n为第二活性组分使用浓度为n时靶标的死亡率(％)。
如果两种活性组分在以一定浓度混合后靶标的实际死亡率大于理论死亡率P，则判定两种活性组分在设定浓度下混合使用具有增效作用，反之则为拮抗作用。
结果见表6。
表6化合物Ⅰ与甲氰菊酯等2个药剂混合使用对朱砂叶螨成螨的协同作用测定
Figure PCTCN2020123112-appb-000010
实施例4含有化合物Ⅰ的组合物对朱砂叶螨的室内活性测定
由上述协同作用测定效果数据可见本发明化合物Ⅰ与甲氰菊酯等2个药剂混合的组合物对朱砂叶螨成螨具有明显的增效效果，进一步以化合物Ⅰ和甲氰菊酯以供试5:1-1:5组成的组合物再用孙云沛(Sun y-p)法进行室内活性测定。
供试靶标：朱砂叶螨(Tetranychus cinnabarinus Boisduval)成螨，室内饲养的敏感品系。
药液配制：根据不同试验需要，用电子分析天平分别准确称取供试样品，其中，原药以丙酮溶解，再用0.1％吐温80水按照试验设计剂量稀释成具一定浓度梯度的系列药液。
试验方法：采用盆栽幼苗喷雾法测定对朱砂叶螨成螨的活性大小。首先将大小一致的朱砂叶螨成螨接到处于第一对真叶平展期的菜豆幼苗(留一片真叶)上，待成螨稳定后计数基数；然后将药液采用Airbrush喷雾法按试验设计从低剂量到高剂量的顺序均匀喷雾，每株1.5mL，每处理4次重复，另设空白对照。
将处理后的试材置于观察室内，观察室的温度、湿度、光照按需可调节。72小时后调查死、活螨数。用abbott公式计算校正死亡率，用DPS数据处理软件进行统计分析，求出各供试单剂及各不同配比混用的毒力回归方程式、LC 50值及95％置信限，再用孙云沛(Sun y-p)法计算各配比的共毒系数，评价混用效果。
混剂的共毒系数(CTC值)按下列公式计算：
Figure PCTCN2020123112-appb-000011
式中：ATI-混剂实测毒力指数；S-标准药剂的LC 50值；M-混剂的LC 50值。
TTI＝TIA×PA+TIB×PB
式中：TTI-混剂理论毒力指数；TIA-A药剂毒力指数；PA-A药剂在混剂中的百分含量；TIB-B药剂毒力指数；PB-B药剂在混剂中的百分含量。
Figure PCTCN2020123112-appb-000012
式中：CTC-共毒系数；ATI-混剂实测毒力指数；TTI-混剂理论毒力指数。
复配剂的共毒系数(CTC)：CTC≥120表现为增效作用；CTC≤80表现为拮抗作用；80<CTC<120表现为相加作用。
且，组合物的LC 50值小于其中一个或两个单剂的LC 50值，则意味着在达到相同效果(死亡率为50％)时，组合物的使用剂量小于其中一个或两个单剂的使用剂量。
以试验结果见表7。
表7：化合物Ⅰ·甲氰菊酯对朱砂叶螨室内联合毒力测定结果
Figure PCTCN2020123112-appb-000013
由上述数据可见化合物Ⅰ·甲氰菊酯配比1对朱砂叶螨LC 50值为0.43mg/L，单剂LC 50值分别为0.46mg/L和5.12mg/L，则意味着在达到相同效果(死亡率为50％)时，组合物的使用剂量(0.43mg/L)小于其中一个或两个单剂的使用剂量(0.46mg/L和5.12mg/L)；另，从共毒系数的定义看，组合物的防治效果也不同程度的高于两种单剂的理论效果；由于田间使用剂量和室内LC 50值正相关，因此组合物田间使用剂量会相应降低，从而降低使用成本，减少环境污染。

Claims (15)

  1. 一种协同杀虫杀螨组合物，其特征在于：组合物为活性组分A和活性组分B，其中，活性组分A和活性组分B之间的重量份数比为1:99～99:1；活性组分A选自化合物Ⅰ，活性组分B选自氟啶胺、联苯肼酯、虫螨腈、Pyflubumider、Acynonspy、拟除虫菊酯类杀虫剂或拟除虫菊酯类杀螨剂；
    所述活性组分A化合物Ⅰ结构如下：
    Figure PCTCN2020123112-appb-100001
  2. 按照权利要求1所述的组合物，其特征在于：所述活性组分B选自甲氰菊酯、高效氟氯氰菊酯、氟氯氰菊酯、氯氟氰菊酯、氯菊酯、Heptafluthrin、Momfluorothrin或氯氰菊酯。
  3. 按照权利要求1或2所述的组合物，其特征在于：所述活性组分A为化合物Ⅰ，活性组分B选甲氰菊酯、高效氟氯氰菊酯、氟氯氰菊酯、氯氟氰菊酯、氯菊酯、Heptafluthrin、Momfluorothrin或氯氰菊酯；两种活性组分的重量份数比为40:1-1:40。
  4. 按照权利要求3所述的组合物，其特征在于：所述活性组分A为化合物Ⅰ，活性组分B选甲氰菊酯或高效氟氯氰菊酯；两种活性组分重量份数比为20:1-1:20。
  5. 按照权利要求4所述的组合物，其特征在于：所述活性组分A为化合物Ⅰ，活性组分B选甲氰菊酯或高效氟氯氰菊酯；两种活性组分重量份数比为10:1-1:10。
  6. 按照权利要求5所述的组合物，其特征在于：所述活性组分A为化合物Ⅰ，活性组分B选甲氰菊酯或高效氟氯氰菊酯；两种活性组分重量份数比为5:1-1:5。
  7. 按照权利要求1所述的组合物，其特征在于：所述活性组分A为化合物Ⅰ，活性组分B选氟啶胺、联苯肼酯或虫螨腈；其中，活性组分A和活性组分B之间的重量份数比为50:1-1:40。
  8. 按照权利要求1所述的组合物，其特征在于：所述活性组分A为化合物Ⅰ，活性组分B选Pyflubumider或Acynonspy；其中，活性组分A和活性组分B之间的重量份数比为40:1-1:40。
  9. 按照权利要求7或8所述的组合物，其特征在于：所述活性组分A为化合物Ⅰ，活性组分B选氟啶胺、联苯肼酯、虫螨腈、Pyflubumider或Acynonspy；其中，活性组分A和活性组分B之间的 重量份数比为10:1-1:10。
  10. 按照权利要求9所述的组合物，其特征在于：所述活性组分A为化合物Ⅰ，活性组分B选氟啶胺、Pyflubumider或Acynonspy；其中，活性组分A和活性组分B之间的重量份数比为5:1-1:5。
  11. 按照权利要求9所述的组合物，其特征在于：所述活性组分A为化合物Ⅰ，活性组分B选联苯肼酯；其中，活性组分A和活性组分B之间的重量份数比为4:1-1:6。
  12. 一种权利要求1所述的协同杀虫杀螨组合物的应用，其特征在于：所述组合物在用于制备控制农业害虫或城市卫生害虫的杀虫杀螨剂中的应用。
  13. 按照权利要求12所述的协同杀虫杀螨组合物的应用，其特征在于：以有效剂量计，将所述组合物施于需要控制的害虫或其生长的介质上。
  14. 一种协同杀虫杀螨制剂，其特征在于：以权利要求1所述组合物作为活性成分与载体和任意一种助剂混合，制成制剂。
  15. 按照权利要求14所述的制剂，其特征在于：所述制剂中组合物的累积含量为0.5wt％-95wt％之间。
PCT/CN2020/123112 2019-10-25 2020-10-23 一种协同杀虫杀螨组合物 WO2021078236A1 (zh)

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CN201911021377.4A CN112704070B (zh) 2019-10-25 2019-10-25 一种含拟除虫菊酯类虫/螨剂的杀虫杀螨组合物
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Citations (3)

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Publication number Priority date Publication date Assignee Title
CN105541682A (zh) * 2014-10-24 2016-05-04 沈阳中化农药化工研发有限公司 一种联苯类化合物及其应用
CN109105376A (zh) * 2018-09-30 2019-01-01 浙江海正化工股份有限公司 防治植物病害的农药组合物及其制备方法
CN110037021A (zh) * 2019-05-22 2019-07-23 侨昌现代农业有限公司 一种含联苯类增效型杀螨剂的杀螨组合物

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Publication number Priority date Publication date Assignee Title
CN105541682A (zh) * 2014-10-24 2016-05-04 沈阳中化农药化工研发有限公司 一种联苯类化合物及其应用
CN109105376A (zh) * 2018-09-30 2019-01-01 浙江海正化工股份有限公司 防治植物病害的农药组合物及其制备方法
CN110037021A (zh) * 2019-05-22 2019-07-23 侨昌现代农业有限公司 一种含联苯类增效型杀螨剂的杀螨组合物

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