WO2021071375A1 - Eau potable fonctionnelle - Google Patents

Eau potable fonctionnelle Download PDF

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Publication number
WO2021071375A1
WO2021071375A1 PCT/RU2019/000713 RU2019000713W WO2021071375A1 WO 2021071375 A1 WO2021071375 A1 WO 2021071375A1 RU 2019000713 W RU2019000713 W RU 2019000713W WO 2021071375 A1 WO2021071375 A1 WO 2021071375A1
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WO
WIPO (PCT)
Prior art keywords
drinking water
water
bacillus
probiotic
biomass
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PCT/RU2019/000713
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English (en)
Russian (ru)
Inventor
Александр Иванович Леляк
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Александр Иванович Леляк
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Priority to PCT/RU2019/000713 priority Critical patent/WO2021071375A1/fr
Publication of WO2021071375A1 publication Critical patent/WO2021071375A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients

Definitions

  • the present invention relates to probiotic health-enhancing drinking water that contains a mixture of probiotic microorganisms and can be used in the food industry, biotechnology and medicine.
  • Probiotics are living cultures of microorganisms that come with food and drinks (water) and have a beneficial effect on the human body by normalizing the physiological, biochemical and immune responses of the human body through stabilization and optimization of the function of its normal microflora.
  • Functional drinking water allows the use of probiotic microorganisms for people with lactose intolerance and people who, for various reasons, do not want to consume dairy products and foods high in colors, flavors and sweeteners.
  • Functional drinking water with microorganisms with probiotic activity has a beneficial effect on the human body as a result of the normalization of the composition and (or) an increase in the biological activity of the normal intestinal microflora.
  • a probiotic immunostimulating supplement for drinking water for animals containing a mixture of probiotic microorganisms, at least two microorganisms selected from the group consisting of Enterococcus faecium, DSM 16211, Lactobacillus reuteri, DSM 16350, and Lactobacillus salivarius ssp. salivarius, DSM 16351, Pediococcus acidilactici, DSM 16210, and Bifidobacterium animalis, DSM 16284 (US Patent N28IOI 170, IPC A23K 1/00, publ. 01.24.2012).
  • bio-oat drinkable food product obtained by processing oats and its derivatives, having a pH from 3.2 to 4.5 and characterized by the content of the following components: 1 , 3-1,4-b ⁇ - glucan with a molecular weight of more than 2,000,000 Da (with a solids content of 2.5-20.0 wt%) - 0.4-2.0 wt%; lactobacilli - 10E7 CFU / g; bifidobacteria - 10E7 CFU / g; water is the rest.
  • bio-oats As a drinking food product, the following components are used as oats and its derivatives: coarse oatmeal, malted oats, raw oats and oat bran.
  • the bio-oat drinkable food product contains from 0.4 to 2.0 wt.% Of high molecular weight 1,3-1,4-pO-glucan, extracted during the processing of oat bran, hydrated and stabilized with the formation of a colloidal solution, coarse oat flour and malted oats, primarily fermented with a mixture consisting of lactobacilli, yeast and bacteria, with the addition of raw oats, while coarse oat flour, malted oats, raw oats and oat bran are taken in a ratio of 1: 3: 11: 15 with the addition of water to dry matter content from 2.5 to 20.0 wt.%, the resulting mixture is re-fermented with probiotic bacteria.
  • the technical result of the invention is to impart a colloidal consistency to a product containing a normalized amount of high molecular weight soluble dietary fibers of oats - 1,3-1,4-pO-glucan by maximizing their extraction from cellular structures, transferring them into solution while creating a substance in which colloidal substances (including hydrated 1,3-1,4-b ⁇ -glucan) envelop the cells of living probiotic bacteria, providing them with protection when passing through the gastrointestinal tract to the large intestine, being a contact food for introduced products and their own probiotic microorganisms, and thereby imparting functional properties to the product symbiotic product.
  • such a drinking product has a short shelf life at room temperature (no more than 5-7 days) and at a temperature of + 2- + 6 ° C for no more than 1-2 months.
  • such a drinking product does not have a prophylactic antiviral effect in regular use and insufficient prophylactic antibacterial action.
  • the closest analogue is functional drinking water for humans, which is supplied with probiotic microorganisms and other substances (vitamins, minerals, dyes, flavors), placed in a separate sealed package in the lid of a water container (Slovenian patent N ° SL2341 1 IPC A23L 2 / 00, published on January 31, 2012).
  • probiotic water contains probiotic microorganisms in quantities ranging from 10 2 microorganisms per milliliter of water to 10 9 microorganisms per milliliter of water.
  • Functional drinking water is prepared before drinking by breaking the sealed package with probiotic and other substances and mixing the contents with drinking water. After mixing the probiotic microorganisms and other components of the contents of the lid with drinking water, the drinking product is ready for ingestion.
  • the technical result of the proposed technical solution is to provide the possibility of a significant increase in the shelf life of functional drinking water with probiotics up to two years with long-term preservation of the activity of probiotics after mixing with water due to the use of probiotic bacteria in spore form and the content of water-soluble substances in it, which stimulate sporulation of probiotic bacteria of the genus Bacillus and inhibit the germination of their spores.
  • the specified technical result is achieved by the fact that functional drinking water containing drinking water, minerals, vitamins and probiotics, according to the invention, it additionally contains amino acids, as probiotics it contains biomass of probiotic bacteria of the genus Bacillus in spore form suspended in drinking water, and mineral substances, vitamins and amino acids are selected from those that are water-soluble substances and stimulate sporulation of probiotic bacteria of the genus Bacillus or inhibit the germination of spores, and D-alanine and glycine are used as amino acids, calcium citrate as minerals, and para-aminobenzoic as vitamins acid and folic acid with the following quantitative content of the components:
  • functional drinking water contains the spore biomass of the Bacillus subtilis strain VKPM B-10641 deposited in the German collection Deutsche Sammlung von Mikroorganismen N ° DSM 24613, which has bactericidal and fungicidal activity, or the biomass of spores of the Bacillus subtilis strain VKPM B-10641 German collection Deutsche Sammlung von Mikroorganismen N ° DSM 24615, which has bactericidal and fungicidal activity, or a mixture in a 1: 1 ratio of spore biomass of the Bacillus subtilis strain VKPM B-10641 (Deutsche Sammlung von Mikroorganismen N ° DSM 24613) and the strain Bacillusfaciens 10643 (Deutsche Sammlung von Mikroorganismen NeDSM 24615).
  • functional drinking water contains purified drinking water, or distilled water, or artesian water, or glacial melt water.
  • Drinking water is packaged and stored in a light-tight room.
  • D-alanine is an amino acid and is used in the food industry as a sweetener or food additive (htp: //ru.foods-additive.com/category/LD-DL- Alanine.htm).
  • Glycine is an amino acid that performs important biological functions in living organisms, participates in protein biosynthesis, is responsible for the normal activity of the nervous system and regulates metabolic processes. Artificially derived aminoacetic acid is used in pharmaceuticals, medicine, and the food industry.
  • Food additive E640 combines aminoacetic acid (glycine) and its sodium salt - compounds which are used to optimize the taste and aroma of products. The additive is safe and officially approved in most countries of the world ihttps: //foodandhealth.ru/dobavki/glicin-i-ego-natrievaya-sol-e640/k
  • Calcium citrate is an exceptional form of calcium in terms of its effectiveness and safety. First, calcium citrate is completely soluble in water. Secondly, calcium from citrate is absorbed regardless of food intake or gastric acidity (htps: //www.lyrach.rU/2014/l 1/15436097 /). The daily intake of calcium is not more than 1200 mg (htp: //mirbodrosti.com/sutochnaya- doza-kaltsiya-dlya-cheloveka-po-vozrastam /).
  • Para-aminobenzoic acid (vitamin B 10) is not produced in the human body.
  • PABA is involved in metabolic processes, affects protein synthesis in the body, being a precursor of folic acid - it helps to prevent megaloblastic anemia.
  • Para-aminobenzoic acid is necessary for normal pigmentation of hair and skin, participates in the formation of sunburn by stimulating the production of melanin, which protects against the penetration of harmful ultraviolet rays into the skin, causing burns and melanomas. Therefore, B 10 has found practical application in the composition of sunscreens. When administered intravenously, it thins the blood and prevents blood clots, reduces the risk of heart attacks and strokes. Increases milk flow during breastfeeding.
  • Folic acid is a water-soluble vitamin necessary for the growth and development of the circulatory and immune systems.
  • vitamins include its derivatives, including di-, tri-, polyglutamates and others. All such derivatives, together with folic acid, are combined under the name folate.
  • a lack of folate can cause megaloblastic anemia in adults, and taking folic acid during pregnancy reduces the risk of developing fetal neural tube defects.
  • the upper limit of the physiological requirement is 1 mg per day (htps: //polzaili.ru/vitamin-b- 9-folievava-kislota-opisanie-vazhnve-svoi stva 1.
  • the amino acids D-alanine and glycine in the stated concentrations have a depressing effect on the germination of spores of bacteria of the genus Bacillus.
  • the Bacillus subtilis strain VKPM B-10641 was deposited in the German collection Deutsche Sammlung von Mikroorganismen NsDSM 24613 and produces biologically active metabolites, including antibiotics and broad-spectrum enzymes that suppress the growth of pathogenic and opportunistic bacterial and fungal microflora.
  • the Bacillus amyloliquefaciens strain VKPM B-10643 was deposited in the German collection Deutsche Sammlung von Mikroorganismen N ° DSM 24615 and produces biologically active metabolites, including antibiotics and broad-spectrum enzymes that suppress the growth of pathogenic and opportunistic bacterial and fungal microflora.
  • Purified water can be obtained from drinking water by distillation (distilled water), ion exchange, reverse osmosis or electrodialysis.
  • distilled water distilled water
  • ion exchange reverse osmosis
  • electrodialysis The preferred and most economical methods for producing purified water are ion exchange or reverse osmosis.
  • Distilled water - purified water practically free of impurities and impurities. Received by distillation in special apparatus - distillers.
  • Artesian waters are pressurized underground waters trapped in aquifers of rocks between water-resistant layers. Usually found within certain geological structures (depressions, troughs, flexures, etc.), forming artesian basins.
  • Glacial melt water is obtained by the natural melting of a glacier in the mountains, passing through solid rocks, while being saturated with minerals and useful microelements.
  • the ratio of minerals (calcium salts), amino acids and vitamins is balanced and does not exceed 17.6 mg / ml in total, which has a beneficial effect on the body when consumed.
  • the claimed functional drinking water has a pleasant taste.
  • Glycine 9.0 mg, calcium citrate 0.6 mg, para-aminobenzoic acid 1.0 mg, folic acid 0.001 mg, suspension in drinking water of biomass of spores of probiotic bacteria strain Bacillus subtilis VKPM B-10641 (DSM 24613) in spore form with a titer
  • Glycine 7.5 mg, calcium citrate 0.45 mg, para-aminobenzoic acid 2.0 mg, folic acid 0.00075 mg, suspension in drinking water of biomass of spores of probiotic bacteria strain Bacillus amyloliquefaciens strain VKPM B-10643 (DSM 24615) in spore form with a titer of 1 10 5 CFU / ml the rest is up to 1 ml Example 4.
  • Glycine 7.5 mg, calcium citrate 0.45 mg, para-aminobenzoic acid 2.0 mg, folic acid 0.00075 mg, suspension in drinking water of a mixture of biomass in a 1: 1 ratio of spores of probiotic bacteria of Bacillus subtilis strains VKPM 10641 (DSM 24613) and Bacillus amyloliquefaciens VKPM 10643 (DSM 24615) in spore form with a titer of each bacterial species at 1-10 CFU / ml, the rest is up to 1 ml.
  • Example 5 Example 5
  • Probiotic strains of bacteria Bacillus subtilis VKPM B-10641 and Bacillus amyloliquefaciens VKPM B-10643 in drinking water are characterized by high antagonistic activity against pathogenic and opportunistic microorganisms.
  • Antagonistic activity against test cultures was tested by the delayed antagonism method.
  • the test strains were Staphylococcus aureus, Candida albicans, Klebsiella pneumonia, Shigella flexneri, Shigella sonnei, Yersinia pseudotuberculosis, Serratia marcescens, Escherichia coli, Enterococcus spp.
  • test strains used met the following requirements: they were in the S - form, had typical morphological and enzymatic properties.
  • the medium was warmed up until the agar was completely dissolved and filtered through a cotton - gauze filter into flasks with a capacity of 500 cm 3 , 300 cm 3 each.
  • the flasks with the medium were closed with cotton wool - gauze plugs, wrapped the neck with parchment and sterilized in an autoclave at a pressure of 0.15 MPa for 40 minutes.
  • the medium was poured into sterile Petri dishes.
  • the dishes with the dried medium were placed in a thermostat at a temperature of (37 + 1) ° ⁇ for (24 + 2) hours. Non-sterile cups were discarded.
  • results were taken into account after 8 hours of incubation at (37 + 1) ° C according to the size of the zones of growth inhibition of test strains.
  • the growth control of pathogen cultures was their parallel plating on Petri dishes with the same solid medium (meat - peptone agar) without the studied association of antagonists.
  • Example 6 Technology of cultivation of bacteria Bacillus subtilis and Bacillus amyloliquefaciens to obtain microbial biomass. To obtain the biomass of bacterial spores, the strains of Bacillus subtilis VKPM B-10641, Bacillus amyloliquefaciens VKPM B-10643 were separately cultivated on a liquid nutrient medium of the following composition:
  • Example 7 Technology for obtaining functional drinking water
  • Example 8 Study of inhibition of spore germination using the claimed mineral substances, vitamins and amino acids that stimulate sporulation of probiotic bacteria of the genus Bacillus and / or inhibit spore germination of these bacteria.
  • Control group JV®2 with the composition of drinking water according to example 1, in which the claimed mineral substances, vitamins and amino acids stimulating sporulation of probiotic bacteria of the genus Bacillus and / or inhibiting the germination of spores of these bacteria have been removed.
  • Test groups JY®3 - with drinking water composition according to example 1; JN®4 - with drinking water composition according to example 2; JN®5 - drinking water composition according to example 3; JV "6 - with the composition of drinking water according to example 4.
  • test groups No. 3, 4, 5 and 6 were heated at 37 ° C for 3 hours and the conditions for spore germination were investigated.
  • the turbidity of each test group after 2 hours was measured at 600 nm using a spectrophotometer.
  • the turbidity of the spore suspension significantly decreased compared to the beginning of the heat treatment, and it was found a significant number of germinated spores (up to 50%).
  • Example 9 Data on the storage of the claimed functional drinking water based on Bacillus subtilis strains VKPM B-10641, VKPM B-10642. To establish the shelf life during storage of the claimed functional drinking water at a temperature of (+ 20 + 0.5) ° C in an opaque room, the corresponding studies are presented in the table. Table
  • Example 10 Description of the mechanism of action of functional drinking probiotic water
  • probiotics With oral intake of functional probiotic drinking water, probiotics enter the gastrointestinal tract (GIT), where there is a powerful representation of the symbiotic bacterial flora and the immune system of the human body (up to 70% of immunocompetent cells).
  • GIT gastrointestinal tract
  • minerals, vitamins and amino acids that stimulate sporulation of probiotic bacteria of the genus Bacillus and inhibit the germination of spores of probiotic bacteria are absorbed by the body and do not interfere with the transition of spores of probiotic bacteria into vegetative form.
  • Probiotic bacteria being a transit microflora, actively multiply and stay in the gastrointestinal tract for 1 to 4 days, and then are excreted from the body.
  • the strain of probiotic bacteria Bacillus subtilis VKPM B-10641 functions in the large intestine
  • the strain of probiotic bacteria Bacillus amyloliquefaciens VKPM B-10643 - in the small intestine which expands the health-improving preventive effect from the use of the claimed probiotic drinking water.

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  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention une eau potable probiotique améliorant la santé, et peut être utilisée dans l'industrie alimentaire, les biotechnologies et en médecine. Le but de la présente invention est de pouvoir augmenter la durée de conservation d'une eau potable fonctionnelle jusqu'à deux ans tout en préservant pendant longtemps l'activité des probiotiques après un mélange avec de l'eau. Cette eau potable fonctionnelle comprend de l'eau, des substances minérales solubles dans l'eau sous forme de citrate de calcium dans une quantité de 0,3 - 0,6 mg, des vitamines solubles dans l'eau sous forme d'acide para-aminobenzoïque dans une quantité de 1,0 à 3,0 mg, et d'acide folique dans une quantité de 0,0005-0,001 mg, de l'acide aminé sous forme de D-alanine dans une quantité de 2, 0-4,0 mg et de la glycine dans une quantité 6,0 - 9,0 mg, des probiotiques mis en suspension dans l'eau potable, une biomasse de bactéries probiotiques du genre Bacillus sous forme de spores avec un titre de 1-102-1 ﬇ 105 КОЕ/ml représentant le reste jusqu'à 1 ml.
PCT/RU2019/000713 2019-10-07 2019-10-07 Eau potable fonctionnelle WO2021071375A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11927791B2 (en) 2020-02-10 2024-03-12 Corning Incorporated Backlights including patterned reflectors

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RU2266020C2 (ru) * 1998-05-13 2005-12-20 Новартис Аг Жидкий питательный продукт (варианты), способ получения жидкого питательного продукта (варианты) и способ поддержания здорового питания человека
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RU2487647C1 (ru) * 2009-06-19 2013-07-20 Пепсико, Инк. Напиток с консервирующей системой, содержащей пимарицин-циклодекстриновый комплекс
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RU2682653C1 (ru) * 2012-12-31 2019-03-20 Ёнчин Фармасьютикал Ко., Лтд. Функциональный пищевой продукт, содержащий очищенный экстракт (atc2), выделенный из pseudolysimachion rotundum var subintegrum, с высоким содержанием активного ингредиента, для предотвращения или лечения воспаления, аллергии и астмы
RU2685883C1 (ru) * 2018-07-25 2019-04-23 Общество С Ограниченной Ответственностью "Диверсус Групп" Витаминизированная питьевая вода

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RU2266020C2 (ru) * 1998-05-13 2005-12-20 Новартис Аг Жидкий питательный продукт (варианты), способ получения жидкого питательного продукта (варианты) и способ поддержания здорового питания человека
RU2270248C1 (ru) * 2004-12-31 2006-02-20 Открытое акционерное общество "Лианозовский молочный комбинат" Штамм бифидобактерий bifidobacterium lactis 668, используемый для приготовления кисломолочных, ферментированных и неферментированных пищевых продуктов, биологически активных добавок, бактериальных препаратов и косметических средств
RU2494645C2 (ru) * 2008-03-18 2013-10-10 Фризлэнд Брэндз Б.В. Пробиотический пищевой продукт с длительным сроком хранения
RU2487647C1 (ru) * 2009-06-19 2013-07-20 Пепсико, Инк. Напиток с консервирующей системой, содержащей пимарицин-циклодекстриновый комплекс
RU2482174C2 (ru) * 2011-02-10 2013-05-20 Александр Иванович Леляк ШТАММЫ БАКТЕРИЙ Bacillus subtilis И Bacillus amyloliquefaciens, ОБЕСПЕЧИВАЮЩИЕ ВОССТАНОВЛЕНИЕ МИКРОБИОЦЕНОЗОВ ПОЧВЫ И ЖЕЛУДОЧНО-КИШЕЧНОГО ТРАКТА ЖИВОТНЫХ, ОБЛАДАЮЩИЕ БАКТЕРИЦИДНОЙ, ФУНГИЦИДНОЙ И ВИРУЛИЦИДНОЙ АКТИВНОСТЬЮ, И ПРЕПАРАТ НА ОСНОВЕ ЭТИХ ШТАММОВ
RU2682653C1 (ru) * 2012-12-31 2019-03-20 Ёнчин Фармасьютикал Ко., Лтд. Функциональный пищевой продукт, содержащий очищенный экстракт (atc2), выделенный из pseudolysimachion rotundum var subintegrum, с высоким содержанием активного ингредиента, для предотвращения или лечения воспаления, аллергии и астмы
RU2685883C1 (ru) * 2018-07-25 2019-04-23 Общество С Ограниченной Ответственностью "Диверсус Групп" Витаминизированная питьевая вода

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11927791B2 (en) 2020-02-10 2024-03-12 Corning Incorporated Backlights including patterned reflectors

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