WO2021043151A1 - 一种呋虫胺油悬浮剂及其制备方法和用途 - Google Patents

一种呋虫胺油悬浮剂及其制备方法和用途 Download PDF

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WO2021043151A1
WO2021043151A1 PCT/CN2020/112944 CN2020112944W WO2021043151A1 WO 2021043151 A1 WO2021043151 A1 WO 2021043151A1 CN 2020112944 W CN2020112944 W CN 2020112944W WO 2021043151 A1 WO2021043151 A1 WO 2021043151A1
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component
oil suspension
dinotefuran
suspension concentrate
combination
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PCT/CN2020/112944
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English (en)
French (fr)
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罗昌炎
詹姆斯•T 布里斯托
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江苏龙灯化学有限公司
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Publication of WO2021043151A1 publication Critical patent/WO2021043151A1/zh
Priority to CONC2022/0004249A priority Critical patent/CO2022004249A2/es

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A01N31/14—Ethers
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/10—Saturated ethers of polyhydroxy compounds
    • C07C43/11—Polyethers containing —O—(C—C—O—)n units with ≤ 2 n≤ 10

Definitions

  • the invention relates to the field of pesticides, in particular to a dinotefuran oil suspension and its preparation method and application.
  • Dinotefuran is a third-generation nicotinic insecticide developed by Japan’s Mitsui Chemicals Company. It has a broad-spectrum insecticide. It is a stimulant for nicotinic acetylcholine receptors and affects the synapses of the insect central nervous system through spinal nerve transmission. It has contact killing and stomach toxicity and has excellent systemic and osmotic effect. Dinotefuran is very safe to mammals, birds and aquatic organisms. It has no phytotoxicity to crops. It can control Hemiptera, Lepidoptera, Coleoptera, Diptera, Hymenoptera and other pests. White-backed planthoppers, Laodelphax striatellus, and black nighttail cicadas have high control effects.
  • dinotefuran has a strong control effect on various pests
  • dinotefuran belongs to a class of poorly soluble active ingredients, and its solubility in water at 25°C is only 40g/L, and its solubility in other medium and low polar solvents is not very good. high. Therefore, for dinotefuran poorly soluble active ingredients or a combination of dinotefuran poorly soluble active ingredients and other agricultural chemicals, it is generally selected to prepare a dispersible oil suspension to increase the utilization of active substances to achieve a synergistic effect.
  • the dispersible oil suspension agent is a highly dispersed and stable suspension system with a non-aqueous system as the dispersion medium. It is a formulation that uses a type of oil that has been tested as a synergist and does not pollute crops as a dilution carrier. Oils include vegetable oils and their derivatives or mineral oils.
  • CN106359440A discloses dinotefuran dispersible oil suspension, wherein the content of each component is: dinotefuran 20-30%, octylphenol polyoxyethylene ether 4-6%, calcium dodecylbenzene sulfonate 4-6% %, phenethyl phenyl propyl phenol polyoxyethylene ether 4 to 6%, organic bentonite 0.8 to 1.2%, white carbon black 0.8 to 1.2%, citric acid 0.1 to 0.5%, dihydrogenated tallow phthalamide 0.1 ⁇ 0.5%, tris(2,4-di-tert-butylphenyl) phosphite 0.1 ⁇ 0.5%, 2-n-octyl-4-isothiazolin-3-one 0.1 ⁇ 0.5%, HT-508 silicone 0.1% ⁇ 0.5%, soybean oil 18 ⁇ 22%, the balance is methyl oleate; this oil suspension agent solves the problems of oil separation, stratification, agglomeration, high decomposition rate and
  • CN109169646A discloses a preparation method of dinotefuran oil suspension, to solve the technical problems of dinotefuran particle size, low efficacy, and mechanical impurities in the preparation obtained by the existing preparation process.
  • the preparation method adopts stirring To control the diameter of the emulsion droplets, this method has a low repetition rate and is difficult to produce on a large scale.
  • CN101784184B discloses a compound with the structural formula RO-(EO) w -(PO) x -(EO) y (PO) x -H as a synergist of neonicotinoid compounds, specifically acetamiprid, and in a specific solvent
  • the composition under the combined condition has a certain effect of increasing the control effect, but the synergistic effect is still low.
  • the present invention finally found a stable and efficient oil suspension concentrate composition containing dinotefuran active substance through countless formulation experiments and bioassay verification. It is physically and chemically stable, especially with excellent insecticidal and control effects.
  • the present invention adopts the following technical solutions:
  • the present invention provides a dinotefuran oil suspension concentrate, which includes the following components:
  • Component A Dinotefuran active that is solid at room temperature
  • Component B at least one synergist of fatty alcohol ethoxylated propoxylate with the general formula RO-(EO) x -(PO) y -OH, wherein R is a C8 ⁇ C20 alkyl group, EO is ethyleneoxy, PO is propyleneoxy, x is an integer of 1-20, and y is an integer of 1-20;
  • C component nonionic surfactant and/or anionic surfactant
  • D component any one or a combination of at least two of vegetable oils, vegetable oil esters or aromatic hydrocarbon solvents.
  • the synergist of the general structure in the B component of which typical but non-limiting examples are C8 ⁇ C20 (for example, C8, C9, C10, C11, C12, C13, C14, C15, C16, C18, C19 or C20) alkyl monohydric alcohol and 1-20 (for example, it can be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 , 16, 18, 20) units of ethyleneoxy and 1-20 (for example, 1, 2, 3, 4, 5, 7, 8, 10, 12, 15, 16, 17, 18, 20 )
  • the ester formed by copolymerization of propyleneoxy block of units for example, C 8 H 17 -O-EO-PO-OH, C 9 H 19 -O-(EO) 2 -(PO) 3 -OH , C11H 23 -O-(EO) 4 -(PO) 5 -OH, C 13 H 27 -O-(EO) 5 -(PO) 7 -OH, C 14 H 29 -O-(EO) 8 -
  • the fatty alcohol ethoxylated propoxylate with the general formula RO-(EO) x -(PO) y -OH is selected as the synergist.
  • This kind of synergist can easily adhere to the surface of the plant and It has a certain dissolving effect on the waxy layer of plants, and enhances the absorption of droplet actives by the stomata and stratum corneum of the plant epidermis, so that the oil suspension concentrate can effectively improve the activity of dinotefuran and significantly improve the oil suspension containing dinotefuran
  • the insecticidal effect reduces the use of dinotefuran and reduces the impact on the environment.
  • R in the general formula RO-(EO) x -(PO) y -OH of the B component is a C8 to C14 alkyl group.
  • x in the general formula RO-(EO) x -(PO) y -OH is an integer of 2-16.
  • y in the general formula RO-(EO) x -(PO) y -OH is an integer of 2-16.
  • the nonionic surfactant is an ethylene oxide-propylene oxide block copolymer, a fatty alcohol polyoxyethylene ether, a polymerization reactant of a fatty alcohol and ethylene oxide and/or propylene oxide, a Base acrylic acid and methacrylate copolymer, alkyl glycoside, polyvinyl alcohol, polyvinylpyrrolidone, alkyl ethoxylate, alkyl aryl ethoxylate or Tween series (polyoxyethylene sorbitan mono A mixture of lauric acid ester and a part of polyoxyethylene bis-sorbitan monolauric acid ester) or a combination of at least two, wherein the typical but non-limiting combination is: fatty alcohol polyoxyethylene ether and alkane Combination of Alkyl Glycoside, Combination of Polyvinyl Alcohol and Alkyl Glycoside, Combination of Polyvinyl Pyrrolidone and Alkyl Ethoxylate, Combination of Alkyl Eth
  • the anionic surfactant is selected from lignin sulfonate (Borresperse NA), succinate sulfonate, naphthalene sulfonate formaldehyde polycondensate, tristyryl phenyl ethoxylate sulfate, three Any one or a combination of at least two of the phosphate or polycarboxylate of styrene ethoxylate, a typical but non-limiting combination is: a combination of lignosulfonate and succinate sulfonate, naphthalene Combination of sulfonate formaldehyde polycondensate and succinate sulfonate, combination of lignosulfonate and naphthalenesulfonate formaldehyde polycondensate, sulfate and succinate sulfonate of tristyryl phenyl ethoxylate
  • lignin sulfonate
  • the vegetable oil is selected from any one or a combination of at least two such as soybean oil, corn oil, rapeseed oil, sunflower oil or peanut oil, wherein a typical but non-limiting combination is: soybean oil and corn oil Combination, combination of soybean oil and sunflower oil, combination of rapeseed oil and corn oil, combination of rapeseed oil and sunflower oil, combination of peanut oil and corn oil, combination of soybean oil and peanut oil.
  • the vegetable oil ester is selected from any one or a combination of at least two such as methyl oleate, epoxy soybean oil, ethyl laurate, methyl palmitate or methyl linoleate, among which are typical but not
  • the restricted combinations are: the combination of methyl oleate and epoxy soybean oil, the combination of methyl oleate and ethyl laurate, the combination of methyl palmitate and ethyl laurate, the combination of ethyl laurate and epoxy
  • the aromatic solvent is selected from any one or a combination of at least two of light aromatic solvents, heavy aromatic solvents, toluene, xylene, mixed trimethylbenzene, Solvesso100, Solvesso150, Solvesso200 or Solvesso200-ND, among which are typical but Non-limiting combinations are: the combination of toluene and xylene, the combination of toluene and mixed trimethylbenzene, the combination of toluene and Solvesso100, the combination of xylene and mixed trimethylbenzene, the combination of mixed trimethylbenzene and Solvesso100, the combination of mixed trimethylbenzene and Solvesso150 The combination of Solvesso100 and Solvesso150, the combination of Solvesso200 and Solvesso150, the combination of Solvesso100 and Solvesso200-ND.
  • the oil suspension concentrate further contains E component: additive.
  • the additive is any one or a combination of at least two of emulsifiers, defoamers, preservatives, antioxidants, colorants or inert fillers, and a typical but non-limiting combination is: emulsifiers and Combinations of defoamers, emulsifiers and preservatives, defoamers and preservatives, antioxidants and colorants, colorants and inert fillers.
  • the emulsifier is a reactant of alkylphenol and ethylene oxide and/or propylene oxide, ethoxylated nonylphenol, castor oil ethoxylate, polyalkoxylated alcohol Mixture (Atlox 4894), alkyl calcium salt, alkyl benzene sulfonate calcium salt, sorbitan derivative or polyethylene oxide-sorbitan fatty acid ester any one or a combination of at least two, among which are typical But non-limiting combinations are: ethoxylated nonylphenol and castor oil ethoxylate, ethoxylated nonylphenol and alkyl calcium salt combination, ethoxylated nonylphenol Combination with alkyl benzene sulfonate calcium salt, combination of castor oil ethoxylate and alkyl calcium salt, combination of alkyl benzene sulfonate calcium salt and sorbitan derivative, alkyl calcium salt and sorbitan derivative The combination of things.
  • the defoamer is a silicone defoamer, preferably a silicone defoamer.
  • the preservative is Proxel series and/or Nipacide series preservatives.
  • antioxidants there are no special restrictions on the type of antioxidants, and antioxidants commonly used for this purpose in agricultural chemical compositions well known to those skilled in the art can be used.
  • the antioxidant is 2,6-di-tert-butyl-4-methylphenol.
  • the colorant is any one or a combination of at least two of titanium dioxide, zinc oxide, blue pigment or light fast red BBN (Pigment Red BBN), wherein a typical but non-limiting combination is: a combination of titanium dioxide and zinc oxide Combination, combination of light fast red BBN and zinc oxide, combination of blue pigment and light fast red BBN, combination of blue pigment and titanium dioxide, combination of light fast red BBN and titanium dioxide, combination of blue pigment and zinc oxide.
  • a typical but non-limiting combination is: a combination of titanium dioxide and zinc oxide Combination, combination of light fast red BBN and zinc oxide, combination of blue pigment and light fast red BBN, combination of blue pigment and titanium dioxide, combination of light fast red BBN and titanium dioxide, combination of blue pigment and zinc oxide.
  • the inert filler is not particularly limited, and those skilled in the art can use inert fillers that are commonly used for this purpose in agricultural chemical compositions, but do not function as thickeners.
  • the inert filler is any one or a combination of at least two of urea, silicate, sulfate or oxide.
  • a typical but non-limiting combination is: a combination of urea and silicate, urea Combination with sulfate, sulfate and silicate, sulfate and oxide, oxide and urea.
  • the oil suspension concentrate further comprises component F: other pesticide actives.
  • the oil suspension containing dinotefuran provided by the present invention does not affect the stability and insecticidal effect of dinotefuran, and the addition of other pesticide active substances can further enhance the insecticidal effect of the oil suspension.
  • the other active pesticides of the present invention can be dissolved in the oil suspension system in molecular form or suspended in the oil suspension system in the form of fine particles.
  • the specific existence mode is related to the nature of the pesticide active substance itself, but it does not affect the suspension of dinotefuran in fine particles in the oil suspension system, which can further enhance the control effect of the oil suspension agent on pests.
  • the other pesticide active substance is an insecticide, such as chlorpyrifos, spirotetramat, alanycarb, aldicarb, aminocarb, Bendiocarb, benfuracarb, bufencarb, butocarboxim, fenobucarb, formate, isoprocarb , Methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, promecarb, thiodicarb, Profenofos, propaphos, prothiofos, pyridaphenthion, pyridathion, sebufos, sulprofos, Tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, vamidothion ), dimethoate, ethoprophos, etrimfos, fenitrothion, fosthia
  • the weight percentage of each component of the oil suspension concentrate is:
  • a component is 1-30%, for example, it can be 1%, 2%, 5%, 5.8%, 6%, 8.4%, 9.5%, 13.1%, 15%, 17%, 19.6%, 21.3%, 25% , 27.8%, 29% or 30%, preferably 5-25%.
  • the B component is 1-15%, for example, it can be 1%, 2%, 4.5%, 6%, 8.3%, 9%, 10%, 11.6%, 13%, 13.8%, 14.3% or 15%, preferably 2 ⁇ 10%.
  • the C component is 1-15%, for example, it can be 1%, 2%, 3%, 4.5%, 6%, 7%, 8%, 8.3%, 10%, 11.6%, 13%, 13.8%, 14.3% Or 15%, preferably 2-8%.
  • the D component is 30 to 80%, for example, it can be 30%, 32%, 35%, 37%, 40%, 44%, 45%, 50%, 53%, 55%, 57%, 65%, 70%, 72%, 75%, 76% or 80%, preferably 40-70%.
  • the E component is 0-20%, for example, it can be 0%, 1%, 2%, 5%, 7%, 8.8%, 10%, 11.2%, 13%, 14%, 15%, 16.2%, 17.4% , 18.5%, 19%, 19.6% or 20%, preferably 1-15%.
  • the F component is 0-30%, for example, it can be 0%, 1%, 2%, 5%, 7%, 8.6%, 10.4%, 12%, 14%, 15%, 16.4%, 17.9%, 19% , 20%, 21%, 23.1%, 25%, 28% or 30%, preferably 5-25%.
  • the oil suspension concentrate provided by the present invention optimizes the insecticidal effect of dinotefuran active substance by using a special synergist and the above-mentioned specific amounts of each component, and effectively improves the biological activity of dinotefuran oil suspension concentrate.
  • the dosage of dinotefuran active substance can achieve better control effect and reduce the pressure on the environment.
  • the present invention provides a method for preparing the dinotefuran oil suspension as described in the first aspect, the preparation method is: combining A component, B component, C component and D component, and The optional E component and F component are stirred and mixed to obtain a mixture, and then the mixture is ground to obtain an oil suspension.
  • the ingredients of the preparation method provided by the invention are mixed in any order, achieving the effects of simple preparation process and reduction of processing costs.
  • the grinding temperature is 10-60°C, for example, 10°C, 15°C, 20°C, 25°C, 30°C, 35°C, 40°C, 45°C, 50°C, 55°C °C or 60 °C, preferably 15 to 45 °C.
  • the preparation method provided by the present invention has mild grinding temperature conditions, reduces energy consumption in the production process, and reduces production costs.
  • the grinding is grinding until the average particle size of the oil suspension concentrate is less than 8 ⁇ m, for example, it may be 0.4 ⁇ m, 0.8 ⁇ m, 1 ⁇ m, 2 ⁇ m, 3 ⁇ m, 3.4 ⁇ m, 5 ⁇ m, 6 ⁇ m, 7 ⁇ m, 7.8 ⁇ m or 8 ⁇ m, It is preferably 1 to 3 ⁇ m.
  • the preparation method provided by the present invention is by grinding the oil suspension concentrate to an average particle size of less than 8 ⁇ m,
  • the oil suspension concentrate has a uniform system and good fluidity under normal temperature storage and/or thermal storage conditions, can maintain stability for a long time, and is convenient for storage and use.
  • the present invention provides a spray liquid containing the dinotefuran oil suspension as described in the first aspect.
  • the oil suspension provided by the present invention can be converted into a uniform spray liquid by diluting with water, and the spray liquid can be applied by conventional methods, for example, spraying, injection, dripping or pouring can be applied.
  • the oil suspension of the present invention has neither obvious emulsion stratification nor destructive flocculation when its concentrated liquid is diluted with water, and has very stable and good physical and chemical properties.
  • the present invention provides a use of the dinotefuran oil suspension as described in the first aspect for plants and/or plant growth environments.
  • the oil suspension concentrate of the present invention When the oil suspension concentrate of the present invention is applied to plants, it can be absorbed by plants in time, enhance the penetration of the oil suspension concentrate by the plant application site, improve application efficiency, enhance the bioavailability of dinotefuran active substance, reduce its dosage, and alleviate the environment pressure.
  • the present invention provides a use of the dinotefuran oil suspension as described in the first aspect for controlling insects.
  • the oil suspension concentrate of the present invention not only has good stability, but also can significantly improve the activity of dinotefuran, the active ingredient of the medicament, and improve the control effect of the oil suspension concentrate on insects.
  • the insects to be controlled are any one or a combination of at least two of Lepidoptera pests, Diptera pests, Hemiptera pests, or Homoptera pests.
  • lepidopteran pests can be Earias insulana, Pieris rapae Linnaeus, Herpetogramma licarsisalis Walker, Spodoptera fugiperda, Spodoptera frugiperda (Spodoptera frugiperda), Rachiplusia nu), Pseudoplusia includens, Sesamia inferens, Cnaphalocrocis medinalis Guenee, Maruca testulalis, Cirphisunipuncta, Tomato Tuta absolutea, Trichoplusia ni, Sesamianonagrioides, Trichoplusia ni, Anticarsiagemmatalis, Grapholitha molesta, Potato Tuber moth (Phthorimaeaoperculella), wheat moth (Sitotroga cerealella), cotton spot moth (Earias vittella Fabricius), cotton brown band moth (Adoxophyes orana
  • Diptera pests can be Aedes aegypti, Liriomyza brassicae, Sarcophaga haemorrhoidalis, Glossina morsitans, Phorbiaantiqua, Ceratitis capitata ), cabbage ground fly (Delia radic ⁇ m), melon fly (Dacuscucurbi tae), horse fly (Tabanus lineola), red head blow fly (Calliphora vricina), carrot stem fly (Psila rosae), orange fruit fly (Bactrocera dorsalis), Culicoides furens, Aedes vexans, Rhagoletis mendax, Chrysomya spp., Chrysops discalis, Phorbia brassicae, Wheat red midge (Si todiplosismosellana), American leaf miner (Liriomyza trifolii), Apple fruit fly (Rhagoletis pomonella), Hippelates, Bactrocera zonat
  • Hemiptera and Homoptera pests can be Sogatellafurcifera Horvrath, Trialeurodes vaporarior ⁇ m, Ieryapurchasi Maskell, Iceryapurchasi, Aphisglycines, Rice fly Lice (Nilapar rata lugens), rice brown planthopper (Nilaparvratalugens), cabbage aphid (Brevicoryne brassicae), sweet potato whitefly (Bemisia tabaci), citrus psyllid (Diaphorina citri), black-tailed leafhopper (Nephotettix nigropictus), red waxworm (Ceroplastesrubens), Aonidiella aurantii, Laodelphax striatellus, Cowpea aphid (Aphis craccivrora Koch), Macrosiphum avenae, Apple aphid (Aphispomi), Psylla aphid (Psylla) , Pe
  • Typical but non-limiting combinations are: the combination of Peregrinus maidis Ashmead and Ieryapurchasi Maskell, the combination of apple fruit fly (Rhagoletis pomonella) and Epinotia aporema (Epinotia aporema), and grape long whiskers
  • the combination of Sparganothis pilleriana and Grapholitha molesta the combination of Sesamia inferens and Pieris rapae Linnaeus, the vertical striped rice planthopper (Sogatodes orizicola Muir) and tobacco bud night
  • a combination of moths Heliothisvirescens
  • a combination of Liriomyza brassicae and a horsefly (Tabanus lineola)
  • Phorbia brassicae and Chrysomya spp. a combination of Lucilia cuprina and smoke
  • Heliothis virescens the combination of Peregrinus maidis Ashmead and Ieryapur
  • the oil suspension is suitable for the control of whitefly, brown planthopper, aphids, scale insects, thrips, rice leaf rollers, rice stem borers, red spiders, prodenia litura, Pieris rapae, diamondback moth, beet night Moths, yellow striped beetles or tea green leafhoppers are preferably used to control brown planthopper and/or Prodenia litura.
  • the present invention has at least the following beneficial effects:
  • the oil suspension concentrate provided by the present invention further improves the insecticidal activity of dinotefuran, and the control effect of dinotefuran is increased to more than 93% after three days of administration, which makes dinotefuran more effective. Insect ability has been further optimized, reducing the use of dinotefuran active substances and reducing the impact on the environment;
  • the synergist used in the oil suspension concentrate provided by the present invention does not affect the conventional physical and chemical properties of the oil suspension concentrate, but still exhibits excellent stability, and is especially suitable for the stability of formulations containing dinotefuran actives;
  • the oil suspension agent provided by the present invention when the oil suspension agent is diluted with water, has neither obvious emulsion stratification nor destructive flocculation, meets the requirements of CAPIC standards, and has very stable and good performance. Physical and chemical properties;
  • the oil suspension concentrate provided by the present invention significantly improves the activity of dinotefuran, can meet the needs of insect control, and can also be applied to plants and/or plant growth environments to enhance the penetration of the oil suspension concentrate at the application site , Improve the application efficiency;
  • the preparation method of the oil suspension concentrate provided by the present invention is simple, easy to operate, and is favorable for industrialized large-scale production.
  • the general formula of the B component synergist in the oil suspension concentrate of the present invention is the fatty alcohol ethoxylated propoxylate of RO-(EO) x -(PO) y -OH.
  • the following is the specific synergist :
  • Synergist A where R is a linear C10 alkyl group, x is 5, y is 5, and the expression is: C 10 H 21 -O-(EO) 5 -(PO) 5 -OH;
  • Synergist B where R is a linear C12 alkyl group, x is 10, y is 5, and the expression is: C 12 H 25 -O-(EO) 10 -(PO) 5 -OH;
  • Synergist C where R is a linear C16 alkyl group, x is 16, y is 8, and the expression is: C 16 H 33 -O-(EO) 16 -(PO) 8 -OH;
  • Synergist D where R is a linear C12 alkyl group, x is 4, y is 16, and the expression is: C 12 H 25 -O-(EO) 4 -(PO) 16 -OH;
  • Synergist E where R is a linear C14 alkyl group, x is 2, y is 10, and the expression is: C 14 H 29 -O-(EO) 2 -(PO) 10 -OH.
  • This embodiment provides a 10% OD oil suspension concentrate of dinotefuran, and the mass content of its components is as follows:
  • Preparation method Mix the above substances in any order under stirring at room temperature, stir uniformly to obtain a suspension, and then pass the suspension through a sand mill at 40° C. through primary coarse grinding and secondary fine grinding to obtain the average particle size of the suspended particles It is a 2 ⁇ m dinotefuran oil suspension.
  • This embodiment provides a 5% OD oil suspension concentrate of dinotefuran, and the mass content of its components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This embodiment provides a 30% OD oil suspension concentrate of dinotefuran, and the mass content of its components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This embodiment provides a dinotefuran oil suspension with 10% dinotefuran and chlorpyrifos 5% OD.
  • the mass content of the components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This embodiment provides an oil suspension of dinotefuran 8% and etofenprox 8% OD, and the mass content of the components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This embodiment provides an oil suspension of 25% dinotefuran and 5% OD of kungfu pyrethroid, and the mass content of the components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This embodiment provides an oil suspension of 5% dinotefuran and 25% OD of bifenthrin, and the mass content of the components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This comparative example provides a 10% OD oil suspension concentrate of dinotefuran, and the mass content of its components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This comparative example provides a 5% OD oil suspension concentrate of dinotefuran, and the mass content of its components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This comparative example provides a 30% OD oil suspension concentrate of dinotefuran, and the mass content of its components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This comparative example provides an oil suspension of 10% dinotefuran and 5% OD of chlorpyrifos.
  • the mass content of the components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This comparative example provides an oil suspension concentrate of Dinotefuran 8% and Ethofenprox 8% OD.
  • the mass content of the components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This comparative example provides an oil suspension of 25% dinotefuran and 5% OD of kungfu pyrethroid.
  • the mass content of the components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This comparative example provides an oil suspension concentrate of dinotefuran 5% and bifenthrin 25% OD.
  • the mass content of the components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • This comparative example uses the prior art formula (CN106359440A Example 1) to provide a 20% OD suspension concentrate of dinotefuran oil.
  • the mass content of the components is as follows:
  • Preparation method add octylphenol polyoxyethylene ether, calcium dodecylbenzene sulfonate and phenethyl propylphenol polyoxyethylene ether to soybean oil and methyl oleate, mix and disperse uniformly, and high-speed shearing
  • Add dinotefuran technical agent under stirring add organic bentonite, white carbon black and HT-508 silicone, mix, grind to a particle size of about 2 ⁇ m, add citric acid, dihydrogenated tallow phthalamide, and triphosphite (2,4-Di-tert-butylphenyl) ester and 2-n-octyl-4-isothiazolin-3-one to prepare dinotefuran dispersible oil suspension concentrate.
  • This comparative example uses the prior art formula (CN109169646A Example 3) to provide a 10% OD oil suspension concentrate of dinotefuran, and the mass content of the components is as follows:
  • step (3) Stir at high speed at 10000rpm, add the dinotefuran aqueous solution of step (1) dropwise to the mixed oil of step (2) at a linear speed of 50m/min to obtain a dispersible oil suspension containing 10% dinotefuran Agent.
  • This comparative example adopts the prior art "synergist I" (CN101784184B Example 1 trade name: Newco12308LY) to provide a dinotefuran oil suspension concentrate, and the mass content of its components is as follows:
  • the preparation method refers to the preparation method of the oil suspension concentrate in Example 1.
  • the dinotefuran oil suspension provided in the examples of the present invention contains the general formula RO-(EO) x -(PO) y-
  • the fatty alcohol ethoxylated propoxylate of OH is used as a synergist to enhance the activity of dinotefuran oil suspension, enhance the insecticidal effect, and have excellent control effects on rice brown planthopper nymphs.
  • brown planthopper can reach more than 53%, and the control effect can reach more than 93% after 3 days of administration; while the comparative examples 1-9 do not contain synergists, and the control effect on brown planthopper is the highest after 1 day of administration. It is only 38.77%, and the highest control effect is only 72.25% after three days of administration. The control effect on brown planthopper is not good.
  • Example 1 shows that although Comparative Example 10 contains a synergist, its control effect on brown planthoppers is only 49.43% after one day of administration, and the control effect is also good after three days of administration. It was only 80.39%, while the prevention and treatment effects of 1 day and 3 days after administration in Example 1 were 59.09% and 93.43%, respectively, indicating that the fat with the general formula RO-(EO) x -(PO) y -OH was used in Example 1. Alcohol ethoxylated propoxylate is used as a synergist. Compared with the Newco 12308LY synergist used in Comparative Example 10, it can enhance the activity of dinotefuran better, and significantly enhance the biological activity of dinotefuran. Insecticidal effect.
  • the present invention adds a fatty alcohol ethoxylated propoxylate with the general formula RO-(EO) x -(PO) y -OH to the dinotefuran oil suspension agent as a synergist.
  • the activity of dinotefuran is improved, the insecticidal control effect is enhanced, and the control effect can reach more than 93% after three days of medication, which can reduce the amount of pesticide active substances used and relieve environmental pressure, and the dinotefuran oil suspension is prepared
  • the process is simple, easy to scale production, reduces production costs, and has greater economic value.

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Abstract

一种呋虫胺油悬浮剂，含有呋虫胺活性物和至少一种通式为R-O-(EO)x-(PO)y-OH 的脂肪醇乙氧基化丙氧基化物的增效剂，其中R 为C8～C20的烷基，EO 为亚乙基氧基，PO 为亚丙基氧基，x 为1～20 的整数，y 为1～20 的整数。

Description

一种呋虫胺油悬浮剂及其制备方法和用途
本申请要求2019年9月6日提交中国专利局、申请号为201910843796.X、发明名称为“一种呋虫胺油悬浮剂及其制备方法和用途”的中国专利申请的优先权，其全部内容通过引用结合在本申请中。
技术领域
本发明涉及农药领域，尤其涉及一种呋虫胺油悬浮剂及其制备方法和用途。
背景技术
呋虫胺，为日本三井化学公司开发的第三代烟碱类杀虫剂，杀虫广谱，为烟碱乙酰胆碱受体的兴奋剂，通过脊柱神经传递影响昆虫中枢神经系统的突触，具有触杀和胃毒作用并具有卓越的内吸渗透作用。呋虫胺对哺乳动物、鸟类及水生生物十分安全，对作物无药害，可防治半翅目、鳞翅目、鞘翅目、双翅目、膜翅目等各种害虫，对水稻褐飞虱、白背飞虱、灰飞虱、黑夜尾蝉等有很高的防效。
尽管呋虫胺对各种害虫具有较强的防效，但呋虫胺属于一类难溶性活性成分，在25℃水中溶解度仅为40g/L，在其他中低极性溶剂中溶解度也不是很高。因此，对于呋虫胺难溶性活性成分或呋虫胺难溶性活性成分与其他农用化学物的组合物，一般选择制备成可分散油悬浮剂来提高活性物的利用率，以达到增效的作用，其中，可分散油悬浮剂是以非水体系为分散介质的高分散稳定悬浮体系，是用一类经过试验可作为增效助剂且不污染作物的油类作为稀释载体的一种剂型，油类包括植物油及其衍生物或矿物油等。
CN106359440A公开了呋虫胺可分散油悬浮剂，其中各组分含量为：呋虫胺20～30％，辛基酚聚氧乙烯醚4～6％，十二烷基苯磺酸钙4～6％，苯乙基苯丙基酚聚氧乙烯醚4～6％，有机膨润土0.8～1.2％，白炭黑0.8～1.2％，柠檬酸0.1～0.5％，双氢化牛脂基 邻苯二甲酰胺0.1～0.5％，亚磷酸三(2，4-二叔丁基苯)酯0.1～0.5％，2-正辛基-4-异噻唑啉-3-酮0.1～0.5％，HT-508有机硅0.1～0.5％，大豆油18～22％，余量为油酸甲酯；该油悬浮剂解决了呋虫胺制剂中存在的析油、分层、结块、分解率高和化学不稳定等问题，但该油悬浮剂对害虫的防效仍然较低，难以充分发挥呋虫胺的活性。
CN109169646A公开了一种呋虫胺油悬浮剂的制备方法，以解决现有制备工艺得到的制剂中呋虫胺颗粒粒径大，药效低，引起机械杂质等技术问题，但该制备方法通过搅拌控制乳状液滴的直径，该方法重复率较低，难以规模化生产。
CN101784184B公开了结构式为R-O-(EO) w-(PO) x-(EO) y(PO) x-H的化合物作为新烟碱类化合物的增效剂，特指啶虫脒，且在特定溶剂组合条件下的组合物，该组合物具有一定的增加防效的效果，但该增效作用仍然较低。
综上所述，现有技术中含呋虫胺的油悬浮剂虽然比呋虫胺其他剂型有增效的作用，但仍然不是很理想。因此，寻找适合呋虫胺油悬浮剂使用的增效助剂，并进一步提高呋虫胺活性是非常必要的。
发明内容
为了解决含呋虫胺油悬浮剂增效的技术问题，本发明通过无数次配方实验和生测验证，终于找到了一种稳定高效的含呋虫胺活性物的油悬浮剂组合物，该组合物是物理化学上稳定的，尤其具有特别优良的杀虫防效。
为达此目的，本发明采用以下技术方案：
第一方面，本发明提供一种呋虫胺油悬浮剂，所述油悬浮剂包括如下组分：
A组分：室温下为固体的呋虫胺活性物；
B组分：至少一种通式为R-O-(EO) x-(PO) y-OH的脂肪醇乙氧基化丙氧基化物的增效剂，其中，R为C8～C20的烷基，EO为亚乙基氧基，PO为亚丙基氧基，x为1～20的整数，y为1～20的整数；
C组分：非离子表面活性剂和/或阴离子表面活性剂；
D组分：植物油、植物油酯化物或芳烃溶剂中的任意一种或至少两种的组合。
本发明中，所述B组分中通式结构的增效剂，其中典型但非限制性的示例为C8～C20(例如可以是C8、C9、C10、C11、C12、C13、C14、C15、C16、C18、C19或C20)烷基的一元醇与1～20(例如可以是1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、18、20)个单元的亚乙基氧基以及1～20(例如可以是1、2、3、4、5、7、8、10、12、15、16、17、18、20)个单元的亚丙基氧基嵌段共聚形成的酯，例如可以是C 8H 17-O-EO-PO-OH、C 9H 19-O-(EO) 2-(PO) 3-OH、C11H 23-O-(EO) 4-(PO) 5-OH、C 13H 27-O-(EO) 5-(PO) 7-OH、C 14H 29-O-(EO) 8-(PO) 8-OH、C 15H 31-O-(EO) 11-(PO) 13-OH、C 15H 31-O-(EO) 14-(PO) 13-OH、C 16H 33-O-(EO) 19-(PO) 17-OH或C 16H 33-O-(EO) 20-(PO) 20-OH，所述C8～C20烷基的一元醇可以是辛醇、癸醇、十二烷醇、十四烷醇、十六烷醇、十七烷醇、十八烷醇或二十烷醇。
本发明中通过选择通式为R-O-(EO) x-(PO) y-OH的脂肪醇乙氧基化丙氧基化物作为增效剂，该类增效剂很容易粘附在植物表面且对植物蜡质层有一定的溶解作用，增强植物表皮气孔和角质层对液滴活性物的吸收，使得油悬浮剂能有效提高呋虫胺的活性，显著提高含呋虫胺的油悬浮剂的杀虫效果，减少了呋虫胺的使用量，降低了对环境的影响。
作为本发明优选的技术方案，所述B组分的通式R-O-(EO) x-(PO) y-OH中的R为C8～C14的烷基。
优选地，所述通式R-O-(EO) x-(PO) y-OH中x为2～16的整数。
优选地，所述通式R-O-(EO) x-(PO) y-OH中y为2～16的整数。
优选地，所述非离子表面活性剂为环氧乙烷-环氧丙烷嵌段共聚物、脂肪醇聚氧乙烯醚、脂肪醇与环氧乙烷和/或环氧丙烷的聚合反应物、甲基丙烯酸与甲基丙烯酸酯的共聚物、烷基糖苷、聚乙烯醇、聚乙烯吡咯烷酮、烷基乙氧基化物、烷基芳基乙氧基化物或Tween系列(聚氧乙烯去水山梨醇单月桂酸酯和一部分聚氧乙烯双去水山梨醇单月桂酸酯的混合物)中的任意一种或至少两种的组合，其中典型但非限制性的组合为： 脂肪醇聚氧乙烯醚和烷基糖苷的组合，聚乙烯醇和烷基糖苷的组合，聚乙烯吡咯烷酮和烷基乙氧基化物的组合，烷基乙氧基化物和烷基糖苷的组合，烷基芳基乙氧基化物和环氧乙烷-环氧丙烷嵌段共聚物的组合，环氧乙烷-环氧丙烷嵌段共聚物和烷基糖苷的组合，脂肪醇聚氧乙烯醚和聚乙烯吡咯烷酮的组合，脂肪醇聚氧乙烯醚和聚乙烯醇的组合。
优选地，所述阴离子表面活性剂选自木质素磺酸盐(Borresperse NA)、琥珀酸磺酸盐、萘磺酸盐甲醛缩聚物、三苯乙烯基苯基乙氧基化物的硫酸盐、三苯乙烯乙氧基化物的磷酸盐或聚羧酸盐中任意一种或至少两种的组合，其中典型但非限制性的组合为：木质素磺酸盐和琥珀酸磺酸盐的组合，萘磺酸盐甲醛缩聚物和琥珀酸磺酸盐的组合，木质素磺酸盐和萘磺酸盐甲醛缩聚物的组合，三苯乙烯基苯基乙氧基化物的硫酸盐和琥珀酸磺酸盐的组合，三苯乙烯基苯基乙氧基化物的硫酸盐和聚羧酸盐的组合，木质素磺酸盐和聚羧酸盐的组合。
优选地，所述植物油选自大豆油、玉米油、菜籽油、葵花油或花生油等任意一种或至少两种的组合物，其中典型但非限制性的组合为：大豆油和玉米油的组合，大豆油和葵花油的组合，菜籽油和玉米油的组合，菜籽油和葵花油的组合，花生油和玉米油的组合，大豆油和花生油的组合。
优选地，所述植物油酯化物选自油酸甲酯、环氧大豆油、月桂酸乙酯、棕榈酸甲酯或亚油酸甲酯等任意一种或至少两种的组合，其中典型但非限制性的组合为：油酸甲酯和环氧大豆油的组合，油酸甲酯和月桂酸乙酯的组合，棕榈酸甲酯和月桂酸乙酯的组合，月桂酸乙酯和环氧大豆油的组合，棕榈酸甲酯和环氧大豆油的组合，亚油酸甲酯和环氧大豆油的组合，油酸甲酯和亚油酸甲酯的组合。
优选地，所述芳烃溶剂选自轻芳烃溶剂、重芳烃溶剂、甲苯、二甲苯、混三甲苯、Solvesso100、Solvesso150、Solvesso200或Solvesso200-ND等任意一种或至少两种的组合物，其中典型但非限制性的组合为：甲苯和二甲苯的组合，甲苯和混三甲苯的组合，甲苯和Solvesso100的组合，二甲苯和混三甲苯的组合，混三甲苯和Solvesso100的组合，混三甲苯和Solvesso150的组合，Solvesso100和Solvesso150的组合，Solvesso200和 Solvesso150的组合，Solvesso100和Solvesso200-ND的组合。
作为本发明优选的技术方案，所述油悬浮剂还包含E组分：添加剂。
优选地，所述添加剂为乳化剂、消泡剂、防腐剂、抗氧化剂、着色剂或惰性填充剂中任意一种或至少两种的组合，其中典型但非限制性的组合为：乳化剂和消泡剂的组合，乳化剂和防腐剂的组合，消泡剂和防腐剂的组合，抗氧化剂和着色剂的组合，着色剂和惰性填充剂的组合。
优选地，所述乳化剂为烷基酚与环氧乙烷和/或环氧丙烷的反应物、乙氧基化的壬基酚、蓖麻油乙氧基化物、多烷氧基化的醇的混合物(Atlox 4894)、烷基钙盐、烷基苯磺酸钙盐、脱水山梨醇衍生物或聚环氧乙烷-脱水山梨醇脂肪酸酯中任意一种或至少两种的组合，其中典型但非限制性的组合为：乙氧基化的壬基酚和蓖麻油乙氧基化物的组合，乙氧基化的壬基酚和烷基钙盐的组合，乙氧基化的壬基酚和烷基苯磺酸钙盐的组合，蓖麻油乙氧基化物和烷基钙盐的组合，烷基苯磺酸钙盐和脱水山梨醇衍生物的组合，烷基钙盐和脱水山梨醇衍生物的组合。
本发明中对所述消泡剂的种类没有特殊限制，可采用本领域技术人员熟知的在农业化学组合物中常用于此目的的消泡剂。
优选地，所述消泡剂为有机硅消泡剂，优选为硅氧烷消泡剂。
本发明中对所述防腐剂的种类也没有特殊限制，可采用本领域技术人员熟知的在农业化学组合物中常用于此目的的防腐剂。
优选地，所述防腐剂为Proxel系列和/或Nipacide系列防腐剂。
本发明中对所述抗氧化剂的种类也没有特殊限制，可采用本领域技术人员熟知的在农业化学组合物中常用于此目的的抗氧化剂。
优选地，所述抗氧化剂为2,6-二叔丁基-4-甲基苯酚。
本发明中对所述着色剂的种类同样没有特殊限制，可采用本领域技术人员熟知的在农业化学组合物中常用于此目的的着色剂。
优选地，所述着色剂为二氧化钛、氧化锌、蓝颜料或耐晒大红BBN(PigmentRed BBN)中任意一种或至少两种的组合，其中典型但非限制性的组合为：二氧化钛和氧化锌的组合，耐晒大红BBN和氧化锌的组合，蓝颜料和耐晒大红BBN的组合，蓝颜料和二氧化钛的组合，耐晒大红BBN和二氧化钛的组合，蓝颜料和氧化锌的组合。
本发明中对所述惰性填充剂没有特殊限制，可采用本领域技术人员熟知的在农业化学组合物中常用于此目的，但不起增稠剂作用的惰性填充剂。
优选地，所述惰性填充剂为尿素、硅酸盐、硫酸盐或氧化物中任意一种或至少两种的组合，其中典型但非限制性的组合为：尿素和硅酸盐的组合，尿素和硫酸盐的组合，硫酸盐和硅酸盐的组合，硫酸盐和氧化物的组合，氧化物和尿素的组合。
优选地，所述油悬浮剂还包含F组分：其他农药活性物。
本发明提供的含呋虫胺的油悬浮剂，在不影响呋虫胺的稳定性和杀虫效果的同时，添加其他农药活性物可进一步增强油悬浮剂的杀虫效果。
本发明所述的其他农药活性物既可以以分子形态溶解在油悬浮剂的体系中，也可以以细小的颗粒悬浮于油悬浮剂的体系中。具体的存在方式与所述农药活性物本身的性质有关，但均不影响呋虫胺以细小颗粒悬浮于油悬浮剂体系中，可进一步增强油悬浮剂对害虫的防效。
优选地，所述其他农药活性物为杀昆虫剂，例如可以是毒死蜱(chlorpyrifos)、螺虫乙酯(spirotetramat)、棉铃威(alanycarb)、涕灭威(aldicarb)、灭害威(aminocarb)、恶虫威(bendiocarb)、丙硫克百威(benfuracarb)、合杀威(bufencarb)、丁酮威(butocarboxim)、仲丁威(fenobucarb)、杀螨脒(formetanate)、异丙威(isoprocarb)、灭虫威(methiocarb)、灭多威(methomyl)、速灭威(metolcarb)、杀线威(oxamyl)、抗蚜威(pirimicarb)、猛杀威(promecarb)、硫双威(thiodicarb)、丙溴磷(profenofos)、丙虫磷(propaphos)、丙硫磷(prothiofos)、哒嗪硫磷(pyridaphenthion)、哒硫磷(pyridathion)、克线丹(sebufos)、硫丙磷(sulprofos)、丁醚硫磷(tebupirimfos)、双硫磷(temephos)、特丁磷(terbufos)、杀虫畏(tetrachlorvinphos)、甲基乙拌磷(thiometon)、 三唑磷(triazophos)、蚜灭多(vamidothion)、乐果(dimethoate)、灭线磷(ethoprophos)、乙嘧硫磷(etrimfos)、杀螟硫磷(fenitrothion)、噻唑磷(fosthiazate)、噁唑磷(isoxathion)、马拉松(malathion)、灭蚜磷(mecarbam)、高效氟氯氰菊酯(beta-cyfluthrin)、醚菊酯(ethofenprox)联苯菊酯(bifenthrin)、氯氰菊酯(cis-cypermethrin)、氯菊酯(clocythrin)、氟氯氰菊酯(cyfluthrin)、三氟氯氰菊酯(cyhalothrin)、苯腈菊酯(cyphenothrin)、溴氰菊酯(deltamethrin)、甲氰菊酯(fenpropathrin)、吡氯氰菊酯(fenpyrithrin)、氰戊菊酯(fenvalerate)、氟氯苯菊酯(flμmethrin)、功夫菊酯(lambda-cyhalothrin)、七氟菊酯(tefluthrin)、啶虫脒(acetamiprid)、噻虫胺(clothianidin)、呋虫胺(dinotefuran)、吡虫啉(imidacloprid)、烯啶虫胺(nitenpyram)、噻虫醛(nithiazine)、噻虫林(thiacloprid)、噻虫嗪(thiamethoxam)、乙酰虫腈(acetoprole)、乙虫腈(ethiprole)、氟虫腈(fipronil)、阿维菌素(abamectin)、阿维菌素(avermectin)、埃玛菌素(emamectin)、依维菌素(ivermectin)、弥拜菌素(milbemectin)、美倍霉素(milbemycin)、环虫酰肼(chromafenozide)、氯虫酰肼(halofenozide)、甲氧虫酰肼(methoxyfenozide)、虫酰肼(tebufenozide)、伏虫脲(diflubenzuron)、氟虫脲(flufenoxuron)、氟铃脲(hexaflμmuron)、虱螨脲(lufenuron)、伏虫隆(teflubenzuron)、联苯肼酯(bifenazate)或噻嗪酮(buprofezin)，优选为拟除虫菊酯类活性物，例如可以是高效氟氯氰菊酯(beta-cyfluthrin)、醚菊酯(ethofenprox)、联苯菊酯(bifenthrin)、氯氰菊酯(cis-cypermethrin)、氯菊酯(clocythrin)、氟氯氰菊酯(cyfluthrin)、三氟氯氰菊酯(cyhalothrin)、苯腈菊酯(cyphenothrin)、溴氰菊酯(deltamethrin)、甲氰菊酯(fenpropathrin)、吡氯氰菊酯(fenpyrithrin)、氰戊菊酯(fenvalerate)、氟氯苯菊酯(flμmethrin)、功夫菊酯(lambda-cyhalothrin)或七氟菊酯(tefluthrin)。
作为本发明优选的技术方案，所述油悬浮剂各组分的重量百分比为：
A组分为1～30％，例如可以是1％、2％、5％、5.8％、6％、8.4％、9.5％、13.1％、15％、17％、19.6％、21.3％、25％、27.8％、29％或30％，优选为5～25％。
B组分为1～15％，例如可以是1％、2％、4.5％、6％、8.3％、9％、10％、11.6％、 13％、13.8％、14.3％或15％，优选为2～10％。
C组分为1～15％，例如可以是1％、2％、3％、4.5％、6％、7％、8％、8.3％、10％、11.6％、13％、13.8％、14.3％或15％，优选为2～8％。
D组分为30～80％，例如可以是30％、32％、35％、37％、40％、44％、45％50％、53％、55％、57％、65％、70％、72％、75％、76％或80％，优选为40～70％。
E组分为0～20％，例如可以是0％、1％、2％、5％、7％、8.8％、10％、11.2％、13％、14％、15％、16.2％、17.4％、18.5％、19％、19.6％或20％，优选为1～15％。
F组分为0～30％，例如可以是0％、1％、2％、5％、7％、8.6％、10.4％、12％、14％、15％、16.4％、17.9％、19％、20％、21％、23.1％、25％、28％或30％，优选为5～25％。
本发明提供的油悬浮剂通过使用特殊的增效剂以及上述特定用量的各组分，使呋虫胺活性物杀虫效果更加优化，有效的提高了呋虫胺油悬浮剂的生物活性，低的呋虫胺活性物用量即能达到较好的防效，减少了对环境的压力。
第二方面，本发明提供一种如第一方面所述的呋虫胺油悬浮剂的制备方法，所述制备方法为：将A组分、B组分、C组分和D组分，以及任选的E组分和F组分搅拌混合得到混合料，再将所述混合料研磨得到油悬浮剂。
本发明提供的制备方法成分彼此以任意顺序混合，达到了制备过程简便，减少加工成本的效果。
作为本发明优选的技术方案，所述研磨的温度为10～60℃，例如可以是10℃、15℃、20℃、25℃、30℃、35℃、40℃、45℃、50℃、55℃或60℃，优选为15～45℃。
本发明提供的制备方法所述研磨的温度条件温和，减少了生产过程的能源消耗，降低了生产成本。
优选地，所述研磨为研磨至所述油悬浮剂的颗粒平均尺寸小于8μm，例如可以是0.4μm、0.8μm、1μm、2μm、3μm、3.4μm、5μm、6μm、7μm、7.8μm或8μm，优选为1～3μm。
本发明提供的制备方法通过将所述油悬浮剂研磨至颗粒平均尺寸小于8μm，
使所述油悬浮剂在常温贮存和/或热贮条件下，体系均匀，流动性好，可长时间保持稳定，便于储存和使用。
第三方面，本发明提供一种喷雾液，所述喷雾液包含如第一方面所述的呋虫胺油悬浮剂。
本发明提供的油悬浮通过用水稀释，可转化为均一的喷雾液，所述喷雾液可通过常规的方法施用，例如可以通过喷雾、注射、点滴或倾倒进行施用。
本发明所述的油悬浮剂，当用水稀释其浓缩液时，既没有明显的乳状液分层，也没有破坏性的絮凝作用，具有非常稳定且良好的理化性质。
第四方面，本发明提供一种如第一方面所述的呋虫胺油悬浮剂用于植物和/或植物生长环境的用途。
本发明所述油悬浮剂施用于植物时，能够被植物及时吸收，增强植物施用部位对于油悬浮剂的渗透，提高施用效率，增强呋虫胺活性物的生物利用度，降低其用量，缓解环境的压力。
第五方面，本发明提供一种如第一方面所述的呋虫胺油悬浮剂用于防治昆虫的用途。
本发明所述油悬浮剂不仅稳定性好，而且能够显著提高其药剂活性成分呋虫胺的活性，提高油悬浮剂对于昆虫的防治效果。
优选地，所述防治的昆虫为鳞翅目害虫、双翅目害虫、半翅目害虫或同翅目害虫中的任意一种或至少两种的组合。
其中，鳞翅目害虫可以是埃及钻夜蛾(Earias insulana)、菜粉蝶(Pieris rapaeLinnaeus)、苍螟(Herpetogramma licarsisalis Walker)、草地贪夜蛾(Spodopterafugiperda)、草地粘虫(Spodoptera frugiperda)、尺蠖(Rachiplusia nu)、大豆夜蛾(Pseudoplusia includens)、稻蛀茎夜蛾(Sesamia inferens)、稻纵卷叶螟(Cnaphalocrocis medinalis Guenee)、豆茄野螟 (Maruca testulalis)、二化螟(Cirphisunipuncta)、番茄斑潜蝇(Tuta absoluta)、粉斑夜蛾(Trichoplusia ni)、粉茎蟆(Sesamianonagrioides)、粉纹夜蛾(Trichoplusia ni)、梨豆夜蛾(Anticarsiagemmatalis)、梨小食心虫(Grapholitha molesta)、马铃薯块茎蛾(Phthorimaeaoperculella)、麦蛾(Sitotroga cerealella)、棉斑实蛾(Earias vittella Fabricius)、棉褐带卷蛾(Adoxophyes orana)、棉红铃虫(Pectinophoragossypiella Saunders)、棉铃虫(Heliothis armigera)、棉叶波纹夜蛾(Alabama argi llacea)、模毒蛾(Lymantriamonacha)、苹果小卷蛾(Cydia pomonella)、苹褐卷蛾(Pandemis heparana)、葡萄小卷叶蛾(Lobesia botrana)、葡萄长须卷蛾(Sparganothis pilleriana)、葡萄小食心虫(Endopiza vriteana Clemens)、三化螟(Scirpophaga incertulas)、甜菜夜蛾(Spodopteraexigua Hübner)、斜纹夜蛾(Spodopteraritura)、烟草粉斑螟(Ephestiaelutella)、烟芽夜蛾(Heliothis virescens)、夜小卷蛾(Epinotia aporema)、衣蛾(Tineolabisselliella)、印度谷斑蝶(Plodiainterpunctella)或玉米螟(Ostrinianubilalis Hübner)；
双翅目害虫可以是埃及伊蚊(Aedes aegypti)、菜潜蝇(Liriomyza brassicae)、赤尾麻蝇(Sarcophaga haemorrhoidalis)、刺舌蝇(Glossina morsi tans)、葱蝇(Phorbiaantiqua)、地中海实蝇(Ceratitis capitata)、甘蓝地种蝇(Delia radicμm)、瓜蝇(Dacuscucurbi tae)、马蝇(Tabanus lineola)、红头丽蝇(Calliphora vricina)、胡萝卜茎蝇(Psila rosae)、桔小实蝇(Bactrocera dorsalis)、狂怒库蠓(Culicoides furens)、剌扰伊蚊(Aedes vexans)、蓝橘绕实蝇(Rhagoletis mendax)、丽蝇(Chrysomya spp.)、鹿蝇(Chrysops discalis)、萝卡蝇(Phorbia brassicae)、麦红吸浆虫(Si todiplosismosellana)、美国潜叶蝇(Liriomyza trifolii)、苹果实蝇(Rhagoletis pomonella)、潜蝇属(Hippelates)、桃实蝇(Bactrocera zonata)、天仙子泉蝇(Pegomya hysocyami)、甜菜泉蝇(Pegomya betae)、铜绿蝇(Lucilia cuprina)或致倦库蚊(Culexquinquefasciatus)；
半翅目和同翅目害虫可以是白背飞虱(Sogatellafurcifera Horvrath)、白粉虱(Trialeurodes vaporariorμm)、吹绵蚧(Ieryapurchasi Maskell)、吹棉蚧(Iceryapurchasi)、大豆蚜(Aphis glycines)、稻飞虱(Nilapar飞rata lugens)、稻褐飞虱(Nilaparvratalugens)、甘蓝蚜(Brevicoryne brassicae)、甘薯粉虱(Bemisia tabaci)、柑桔木虱(Diaphorina citri)、黑尾叶蝉(Nephotettix nigropictus)、红蜡蚧(Ceroplastesrubens)、红圆蚧(Aonidiella aurantii)、灰飞虱 (Laodelphax striatellus)、豇豆蚜(Aphis craccivrora Koch)、麦长管蚜(Macrosiphμm avenae)、苹果蚜(Aphispomi)、苹木虱(Psylla mali)、桃短尾蚜(Brachycaudus persicae)、桃蚜(MyzuspersicaeSulzer)、豌豆蚜(Acyrthisiphon pis μm Harris)、温室白粉虱(Trialeurodesvaporariorμm)、烟粉虱(Bemisia tabaci Gennadius)、叶蝉(Empoasca spp.)、玉米花翅飞虱(Peregrinus maidis)、玉米蜡蝉(Peregrinus maidisAshmead)、玉米蚜(Rhopalosiph μm maidis)或纵条稻飞虱(Sogatodes orizicola Muir)；
其中典型但非限制性的组合为：玉米蜡蝉(Peregrinus maidisAshmead)和吹绵蚧(Ieryapurchasi Maskell)的组合，苹果实蝇(Rhagoletis pomonella)和夜小卷蛾(Epinotia aporema)的组合，葡萄长须卷蛾(Sparganothis pilleriana)和梨小食心虫(Grapholitha molesta)的组合，稻蛀茎夜蛾(Sesamia inferens)和菜粉蝶(Pieris rapaeLinnaeus)的组合，纵条稻飞虱(Sogatodes orizicola Muir)和烟芽夜蛾(Heliothisvirescens)的组合，菜潜蝇(Liriomyza brassicae)和马蝇(Tabanus lineola)的组合，萝卡蝇(Phorbia brassicae)和丽蝇(Chrysomya spp.)的组合，铜绿蝇(Lucilia cuprina)和烟芽夜蛾(Heliothis virescens)的组合。
优选地，所述油悬浮剂适用于防治烟粉虱、褐飞虱、蚜虫、介壳虫、蓟马、稻纵卷叶螟、三化螟、红蜘蛛、斜纹夜蛾、菜青虫、小菜蛾、甜菜夜蛾、黄条跳甲或茶小绿叶蝉，优选为防治褐飞虱和/或斜纹夜蛾。
与现有技术相比，本发明至少具有以下有益效果：
(1)本发明所提供的油悬浮剂与现有的油悬浮剂相比，进一步提高了呋虫胺的杀虫活性，用药三天的防效提升至93％以上，使呋虫胺的杀虫能力得到进一步优化，减少了呋虫胺活性物的使用量，降低了对环境的影响；
(2)本发明所提供的油悬浮剂使用的增效剂不影响油悬浮剂常规的理化性能，仍然表现出优异的稳定性，尤其适合用于含有呋虫胺活性物的制剂稳定性；
(3)本发明所提供的油悬浮剂，当用水稀释所述油悬浮剂时，既无明显的乳状液分层，也无破坏性的絮凝作用，满足CAPIC标准要求，具备非常稳定和良好的理化性质；
(4)本发明所提供的油悬浮剂，显著提高了呋虫胺的活性，可满足于昆虫防治的需要，还可施用于植物和/或植物生长环境，增强施用部位对油悬浮剂的渗透，提高了施用效率；
(5)本发明所提供的油悬浮剂的制备方法简单，易于操作，有利于进行工业化大规模生产。
具体实施方式
为便于理解本发明，本发明列举实施例如下。本领域技术人员应该明了，所述实施例仅仅是帮助理解本发明，不应视为对本发明的具体限制。
一、增效剂
本发明所述油悬浮剂中B组分增效剂的通式为R-O-(EO) x-(PO) y-OH的脂肪醇乙氧基化丙氧基化物，以下为具体的增效剂：
增效剂A：其中R为直链C10烷基，x为5，y为5，表达式为：C 10H 21-O-(EO) 5-(PO) 5-OH；
增效剂B：其中R为直链C12烷基，x为10，y为5，表达式为：C 12H 25-O-(EO) 10-(PO) 5-OH；
增效剂C：其中R为直链C16烷基，x为16，y为8，表达式为：C 16H 33-O-(EO) 16-(PO) 8-OH；
增效剂D：其中R为直链C12烷基，x为4，y为16，表达式为：C 12H 25-O-(EO) 4-(PO) 16-OH；
增效剂E：其中R为直链C14烷基，x为2，y为10，表达式为：C 14H 29-O-(EO) 2-(PO) 10-OH。
二、实施例
实施例1
本实施例提供了一种呋虫胺10％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000001
制备方法：在室温搅拌下以任意顺序混合以上物质，搅拌均匀得到悬浮液，将所述悬浮液在40℃下经砂磨机一级粗磨和二级细磨，得到悬浮颗粒平均粒径大小为2μm的呋虫胺油悬浮剂。
实施例2
本实施例提供了一种呋虫胺5％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000002
Figure PCTCN2020112944-appb-000003
其制备方法参照实施例1中油悬浮剂的制备方法。
实施例3
本实施例提供了一种呋虫胺30％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000004
其制备方法参照实施例1中油悬浮剂的制备方法。
实施例4
本实施例提供了一种呋虫胺10％和毒死蜱5％OD的呋虫胺油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000005
Figure PCTCN2020112944-appb-000006
其制备方法参照实施例1中油悬浮剂的制备方法。
实施例5
本实施例提供了一种呋虫胺8％和醚菊酯8％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000007
其制备方法参照实施例1中油悬浮剂的制备方法。
实施例6
本实施例提供了一种呋虫胺25％和功夫菊酯5％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000008
其制备方法参照实施例1中油悬浮剂的制备方法。
实施例7
本实施例提供了一种呋虫胺5％和联苯菊酯25％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000009
Figure PCTCN2020112944-appb-000010
其制备方法参照实施例1中油悬浮剂的制备方法。
三、对比例
对比例1
本对比例提供了一种呋虫胺10％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000011
其制备方法参照实施例1中油悬浮剂的制备方法。
对比例2
本对比例提供了一种呋虫胺5％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000012
其制备方法参照实施例1中油悬浮剂的制备方法。
对比例3
本对比例提供了一种呋虫胺30％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000013
其制备方法参照实施例1中油悬浮剂的制备方法。
对比例4
本对比例提供了一种呋虫胺10％和毒死蜱5％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000014
其制备方法参照实施例1中油悬浮剂的制备方法。
对比例5
本对比例提供了一种呋虫胺8％和醚菊酯8％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000015
Figure PCTCN2020112944-appb-000016
其制备方法参照实施例1中油悬浮剂的制备方法。
对比例6
本对比例提供了一种呋虫胺25％和功夫菊酯5％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000017
其制备方法参照实施例1中油悬浮剂的制备方法。
对比例7
本对比例提供了一种呋虫胺5％和联苯菊酯25％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000018
Figure PCTCN2020112944-appb-000019
其制备方法参照实施例1中油悬浮剂的制备方法。
对比例8
本对比例利用现有技术配方(CN106359440A实施例1)提供了一种呋虫胺油20％OD的悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000020
Figure PCTCN2020112944-appb-000021
制备方法：在大豆油和油酸甲酯中加入辛基酚聚氧乙烯醚、十二烷基苯磺酸钙和苯乙基苯丙基酚聚氧乙烯醚，混合、分散均匀，高速剪切搅拌下加入呋虫胺原药，加入有机膨润土和白炭黑和HT-508有机硅，混合，研磨至粒径为2μm左右，加入柠檬酸、双氢化牛脂基邻苯二甲酰胺、亚磷酸三(2,4-二叔丁基苯)酯、2-正辛基-4-异噻唑啉-3-酮，制得呋虫胺可分散油悬浮剂。
对比例9
本对比例利用现有技术配方(CN109169646A实施例3)提供了一种呋虫胺10％OD的油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000022
制备方法：
(1)将呋虫胺和溶剂混合，在500rpm搅拌下加热至58℃，使得呋虫胺完全溶解于蒸馏水中；加入苯乙烯基酚聚氧乙烯醚和聚羧酸盐继续搅拌，得到呋虫胺水剂；
(2)将烷基苯磺酸盐、凹凸棒土和大豆油混合，在700rpm下机械搅拌至均匀，得到混合油剂；
(3)在10000rpm下高速搅拌，将步骤(1)的呋虫胺水剂按50m/min的线速度滴加入步骤(2)的混合油剂中，得到含10％呋虫胺可分散油悬浮剂。
对比例10
本对比例采用现有技术中的“增效剂I”(CN101784184B实施例1商品名：Newco12308LY)，提供了一种呋虫胺油悬浮剂，其组分的质量含量如下所示：
Figure PCTCN2020112944-appb-000023
其制备方法参照实施例1中油悬浮剂的制备方法。
四、理化性能测试
将上述实施例1-7的样品进行分散稳定性测试，将5ml样品分别加入到装有标准水的250ml的量筒中稀释，用标准水补足到250ml刻度线，摇匀后静置在30℃恒温水浴槽中，0.5小时、24小时、24.5小时分别观察稀释液(参考CIPACMT180方法)。分散稳定性测试结果如表1所示。
表1
Figure PCTCN2020112944-appb-000024
从表1可以看出，本发明的实施例1～7提供的呋虫胺油悬浮剂兑水稀释后，无乳状液分层现象，也无破坏性的絮凝作用，分别在0.5小时、24小时和24.5小时的测试效果显示，其分散稳定性好，满足CAPIC标准要求，具备非常稳定和良好的理化性质。
五、生物活性测试
将上述实施例1～7和对比例1～10的样品分别用水稀释得到含呋虫胺10mg/l(10ppm)的水溶液备用。
供试生物：
褐飞虱3龄若虫。成虫于2017年采自农科院试验田，在室内用感虫水稻品种饲养1年。
试验方法：
采用稻茎浸渍法。将约10cm长的连根稻茎(带部分根)分别在药液中浸30s， 取出后晾至稻茎上无明水，放入带水的开口杯中，上部以封口膜封口。以清水浸渍作为对照。挑取3龄褐飞虱若虫放入开口杯中，每杯7～14头。试验温度为26±1℃、光照L:D＝16:8h。24h、72h分别检查活虫数。每个样品设3次重复，取平均值。
药效计算方法：
Figure PCTCN2020112944-appb-000025
Figure PCTCN2020112944-appb-000026
对褐飞虱若虫的防治效果如表2所示。
表2
Figure PCTCN2020112944-appb-000027
从表2可以看出，综合实施例1～7和对比例1～9可知，本发明实施例提供的呋虫胺油悬浮剂中含有通式为R-O-(EO) x-(PO) y-OH的脂肪醇乙氧基化丙氧基化物作为增效剂，提升了呋虫胺油悬浮剂的活性，增强了杀虫效果，对水稻褐飞虱若虫有优异的防治效果，其中，给药1天后其对褐飞虱的防治效果可达53％以上，而给药3天后的防治效果更可达到93％以上；而对比例1～9中不含增效剂，给药1天时对褐飞虱的防治效果最高仅为38.77％，给药三天后防治效果最高也仅为72.25％，对褐飞虱的防治效果欠佳。
从表2可以看出，综合实施例1和对比例10可知，尽管对比例10中含有增效剂，但其给药1天时对褐飞虱的防治效果仅为49.43％，给药三天后防治效果也仅为80.39％，而实施例1中给药1天和3天后防治效果分别为59.09％和93.43％，表明实施例1采用通式为R-O-(EO) x-(PO) y-OH的脂肪醇乙氧基化丙氧基化物作为增效剂，较对比例10中采用的Newco 12308LY增效剂，可使呋虫胺活性的增强效果更佳，显著提升了呋虫胺的生物活性，增强了杀虫效果。
综上所述，本发明通过在呋虫胺油悬浮剂中添加通式为R-O-(EO) x-(PO) y-OH的脂肪醇乙氧基化丙氧基化物作为增效剂，显著提升了呋虫胺的活性，增强了杀虫防效，用药三天的防效可达93％以上，可减少农药活性物的使用量，缓解环境压力，且所述呋虫胺油悬浮剂制备工艺简单，易规模化生产，降低了生产成本，具有较大的经济价值。
申请人声明，本发明通过上述实施例来说明本发明的含呋虫胺的油悬浮剂及其制备方法和用途，但本发明并不局限于上述实施例，即不意味着本发明必须依赖上述实施例才能实施。所属技术领域的技术人员应该明了，对本发明的任何改进，对本发明产品各原料的等效替换及辅助成分的添加、具体方式的选择等，均落在本发明的保护范围和公开范围之内。

Claims (10)

  1. 一种呋虫胺油悬浮剂，其特征在于，所述油悬浮剂包括如下组分：
    A组分：室温下为固体的呋虫胺活性物；
    B组分：至少一种通式为R-O-(EO)x-(PO)y-OH的脂肪醇乙氧基化丙氧基化物的增效剂，其中R为C8～C20的烷基，EO为亚乙基氧基，PO为亚丙基氧基，x为1～20的整数，y为1～20的整数；
    C组分：非离子表面活性剂和/或阴离子表面活性剂；
    D组分：植物油、植物油酯化物或芳烃溶剂中的任意一种或至少两种的组合。
  2. 根据权利要求1所述的油悬浮剂，其特征在于，所述B组分的通式R-O-(EO) x-(PO) y-OH中的R为C8～C14的烷基；
    优选地，所述通式R-O-(EO) x-(PO) y-OH中的x为2～16的整数；
    优选地，所述通式R-O-(EO) x-(PO) y-OH中的y为2～16的整数。
  3. 根据权利要求1或2所述的油悬浮剂，其特征在于，所述油悬浮剂还包含E组分：添加剂；
    优选地，所述添加剂为乳化剂、消泡剂、防腐剂、抗氧化剂、着色剂或惰性填充剂中的任意一种或至少两种的组合；
    优选地，所述油悬浮剂还包含F组分：其他农药活性物；
    优选地，所述其他农药活性物为杀昆虫剂，优选为拟除虫菊酯类杀虫剂。
  4. 根据权利要求1～3任一项所述的油悬浮剂，其特征在于，所述油悬浮剂包含如下重量百分比的各组分：A组分：1～30％；B组分：1～15％；C组分：1～15％；D组分：30～80％；E组分：0～20％；F组分：0～30％。
  5. 根据权利要求4所述的油悬浮剂，其特征在于，所述A组分的重量百分比为 5～25％；
    优选地，所述B组分的重量百分比为2～10％；
    优选地，所述C组分的重量百分比为2～8％；
    优选地，所述D组分的重量百分比为40～70％；
    优选地，所述E组分的重量百分比为1～15％；
    优选地，所述F组分的重量百分比为5～25％。
  6. 根据权利要求1～5任一项所述的呋虫胺油悬浮剂的制备方法，其特征在于，所述制备方法为：将A组分、B组分、C组分和D组分，以及任选的E组分和F组分搅拌混合得到混合料，再将所述混合料研磨得到油悬浮剂。
  7. 根据权利要求6所述的制备方法，其特征在于，所述研磨的温度为10～60℃，优选为15～45℃；
    优选地，所述研磨为研磨至所述油悬浮剂的颗粒平均尺寸小于8μm，优选为1～3μm。
  8. 一种喷雾液，其特征在于，所述喷雾液包含如权利要求1～5任一项所述的呋虫胺油悬浮剂。
  9. 根据权利要求1～5任一项所述的呋虫胺油悬浮剂用于植物和/或植物生长环境的用途。
  10. 根据权利要求1～5任一项所述的呋虫胺油悬浮剂用于防治昆虫的用途；优选地，所述防治的昆虫为鳞翅目害虫、双翅目害虫、半翅目害虫或同翅目害虫中的任意一种或至少两种的组合，优选为半翅目害虫，进一步优选为褐飞虱。
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CN101287373A (zh) * 2005-09-09 2008-10-15 拜尔农作物科学股份公司 Cni-od制剂用于防治粉虱的用途
CN101321464A (zh) * 2005-10-11 2008-12-10 拜尔农作物科学股份公司 油基悬浮剂
CN101534640A (zh) * 2006-09-15 2009-09-16 拜尔农作物科学股份公司 油基悬浮剂

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Publication number Priority date Publication date Assignee Title
CN101287373A (zh) * 2005-09-09 2008-10-15 拜尔农作物科学股份公司 Cni-od制剂用于防治粉虱的用途
CN101321464A (zh) * 2005-10-11 2008-12-10 拜尔农作物科学股份公司 油基悬浮剂
CN101534640A (zh) * 2006-09-15 2009-09-16 拜尔农作物科学股份公司 油基悬浮剂

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