WO2021026733A1 - Dispositif d'administration par inhalation et structure d'administration combinée par inhalation - Google Patents

Dispositif d'administration par inhalation et structure d'administration combinée par inhalation Download PDF

Info

Publication number
WO2021026733A1
WO2021026733A1 PCT/CN2019/100241 CN2019100241W WO2021026733A1 WO 2021026733 A1 WO2021026733 A1 WO 2021026733A1 CN 2019100241 W CN2019100241 W CN 2019100241W WO 2021026733 A1 WO2021026733 A1 WO 2021026733A1
Authority
WO
WIPO (PCT)
Prior art keywords
powder
swirling
drug delivery
delivery device
inhalation drug
Prior art date
Application number
PCT/CN2019/100241
Other languages
English (en)
Chinese (zh)
Inventor
张江
Original Assignee
张江
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 张江 filed Critical 张江
Priority to PCT/CN2019/100241 priority Critical patent/WO2021026733A1/fr
Publication of WO2021026733A1 publication Critical patent/WO2021026733A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators

Definitions

  • the present disclosure relates to the technical field of medical appliances, in particular to an inhalation drug delivery device and a combined structure of inhalation drug delivery.
  • COPD chronic obstructive pulmonary disease
  • Pulmonary inhalation is the first choice therapy for COPD and most lung diseases similar to COPD. It has the characteristics of targeting, high efficiency, quick effect, and small side effects.
  • Common formulations for inhalation administration include solution atomization, metered atomization and dry powder mist. Compared with solution atomization and metered atomization, dry powder aerosol has good compliance with inhalation administration, and is especially suitable for patients with chronic obstructive pulmonary disease.
  • the inhalation drug delivery device of the inhalation drug combination structure in the prior art has a poor suction effect on the powder.
  • the purpose of the present disclosure is to provide an inhalation drug delivery device and a combined structure for inhalation drug delivery to optimize the suction effect of the powder.
  • the first aspect of the present disclosure provides an inhalation drug delivery device.
  • the inhalation drug delivery device includes a vent for introducing external air, a medicine box placement cavity for placing a medicine box, and a medicine powder accommodating cavity for sucking the medicine box.
  • the air-powder suction port of the medicinal powder, and the inhalation drug delivery device further includes a first swirling structure which is arranged between the vent and the medicinal powder accommodating cavity and is used to cause the airflow to generate a swirl before the medicinal powder is blown.
  • the inhalation drug delivery device further includes a flow-sharing structure disposed between the vent and the first swirling structure.
  • the first swirl structure includes an air inlet end, an air outlet end, and a swirl channel arranged between the air inlet end and the air outlet end.
  • the swirl channel includes a swirling channel that surrounds from the center of the flow channel to the edge of the flow channel. Two or more swirling parts are arranged, and each swirling part is used to produce a swirling flow of part of the air flow input into it and output it.
  • the first swirl flow structure further includes an outer flow guide surface arranged on the outside of the first swirl part counted from the edge of the flow channel, and the outer flow guide surface is at least on the side of the air outlet end from the swirl flow channel.
  • the expansion area gradually increases from upstream to downstream.
  • the expansion surface includes a tapered surface structure.
  • an isolation structure for isolating the air flows of the two swirling parts is provided between adjacent swirling parts.
  • the isolation structure includes a first intermediate flow guide surface for guiding the airflow of the swirling part close to the center of the two swirling parts for its isolation and/or two swirling parts for isolating it.
  • the second intermediate flow guiding surface of the swirling part near the edge of the flow part to guide the air flow.
  • the first intermediate guide surface at least on the side of the air outlet end is an expansion surface whose cross-sectional area gradually increases from upstream to downstream of the swirl flow channel; and/or, the second intermediate guide surface is at least The side of the air outlet end is an expansion surface whose cross-sectional area gradually increases from the upstream to the downstream of the swirl flow channel.
  • the first swirling structure is arranged at the opening of the powder containing cavity for introducing airflow.
  • the inhalation drug delivery device further includes a second swirling flow structure arranged between the medicinal powder accommodating cavity and the wind powder suction port and used to generate a swirling flow of the wind powder mixture.
  • the inhalation drug delivery device further includes an air powder acceleration channel provided between the first swirl structure and the second swirl structure; and/or the inhalation drug delivery device further includes a second swirl structure The rectifying structure between the wind powder suction port.
  • the second swirling structure includes a swirling channel and swirling vanes arranged in the swirling channel.
  • the second aspect of the present disclosure provides an inhalation drug delivery combination structure, including a medicine box and an inhalation drug delivery device for sucking the powder placed in the medicine box.
  • the medicine box has a powder accommodating cavity for placing the powder.
  • the device includes a vent for introducing outside air, a medicine box placement cavity for placing the medicine box, and an air powder suction port for sucking the medicine powder in the medicine powder accommodating cavity.
  • the inhalation drug delivery device also includes a vent and A first swirling flow structure between the powder accommodating cavities and used for causing the airflow to generate swirling flow before blowing the powder.
  • the medicine box has an air inlet for introducing external air, and the first swirl structure is disposed at the air inlet.
  • the first swirl structure includes an air inlet end, an air outlet end, and a swirl channel arranged between the air inlet end and the air outlet end.
  • the swirl channel includes a swirling channel that surrounds the flow channel from the inner side to the outer side of the flow channel. Two or more swirling parts are arranged, and each swirling part is used to produce a swirling flow of part of the air flow input into it and output it.
  • the inhalation drug delivery device further includes a second swirling flow structure arranged between the medicinal powder accommodating cavity and the wind powder suction port and used to generate a swirling flow of the wind powder mixture.
  • the second swirling structure includes a swirling channel and swirling vanes arranged in the swirling channel.
  • the inhalation drug delivery device includes a vent for introducing external air, a medicine box placement cavity for placing a medicine box, and a medicine powder container for sucking the medicine box
  • the air powder suction port for the powder in the cavity and the inhalation drug delivery device further includes a first swirling structure arranged between the vent and the powder containing cavity and used for causing the airflow to generate a swirl before the powder is blown.
  • the first swirling structure of the inhalation drug delivery device of the present disclosure causes the airflow to generate a swirling flow before the powder is blown, and the powder is blown out of the powder containing cavity more effectively, thereby optimizing the suction effect of the powder.
  • FIG. 1 is a schematic diagram of a three-dimensional structure of an inhalation drug delivery combination structure of an embodiment of the disclosure
  • FIG. 2 is a schematic diagram of another perspective three-dimensional structure of the combined structure of inhalation drug delivery according to the embodiments of the disclosure.
  • Figure 3 is a schematic diagram of an exploded structure of the inhalation drug delivery combination structure shown in Figure 1;
  • Figure 4 is a schematic diagram of the structure of the box in Figure 3;
  • FIG. 5 is a schematic structural view of one angle of the first accommodating body and the second accommodating body in FIG. 3;
  • FIG. 6 is a schematic structural view of another angle of the first accommodating body and the second accommodating body in FIG. 3;
  • Fig. 7 is a schematic structural diagram of each first swirl structure in Fig. 3;
  • Fig. 8 is a schematic structural diagram of a first swirl structure in Fig. 3;
  • Figure 9 is a schematic diagram of the structure of the turntable in Figure 3.
  • FIG. 10 is a schematic structural diagram of another angle of the turntable shown in FIG. 9;
  • Figure 11 is a schematic diagram of the structure of the elastic element in Figure 3.
  • Figure 12 is a schematic view of the structure of the pawl plate in Figure 3;
  • Figure 13 is a schematic diagram of the structure of the mounting plate in Figure 3;
  • Figure 14 is a schematic diagram of the structure of the limit plate in Figure 3;
  • Figure 15 is a schematic diagram of the structure of the outer ring of the turntable in Figure 3;
  • Fig. 16 is a schematic diagram of the structure of the sign disc in Fig. 3;
  • FIG. 18 is a schematic diagram of the structure of the second housing in FIG. 3;
  • Figure 19 is a schematic diagram of the structure of the trachea in Figure 3.
  • Fig. 20 is a schematic structural view of one direction of the suction nozzle in Fig. 3;
  • Fig. 21 is a schematic structural view of the suction nozzle in Fig. 3 in another direction.
  • spatially relative terms such as “above”, “above”, “above”, “above”, etc. can be used here to describe as shown in the figure. Shows the spatial positional relationship between one device or feature and other devices or features. It should be understood that the spatially relative terms are intended to encompass different orientations in use or operation other than the orientation of the device described in the figure. For example, if the device in the figure is inverted, then the device described as “above the other device or structure” or “above the other device or structure” will then be positioned as “below the other device or structure” or “on Under other devices or structures”. Thus, the exemplary term “above” can include both orientations “above” and “below”. The device can also be positioned in other different ways (rotated by 90 degrees or in other orientations), and the relative description of the space used here is explained accordingly.
  • the inhalation drug delivery device of the embodiment of the present disclosure includes a vent for introducing external air, a medicine box placement cavity for placing a medicine box, and an air powder suction port for sucking medicine powder in the medicine powder accommodating cavity of the medicine box.
  • the inhalation drug delivery device also includes a first swirling structure arranged between the vent and the powder accommodating cavity and used for causing the airflow to generate swirl before the powder is blown.
  • the inhalation drug delivery device of the embodiment of the present disclosure generates a swirling flow on the airflow before impacting the powder by setting the first swirl structure to blow the powder out more effectively, thereby improving the suction effect of the powder.
  • the inhalation drug delivery device further includes a second swirling flow structure arranged between the medicinal powder accommodating cavity and the wind powder suction port and used to generate a swirling flow of the wind powder mixture.
  • the second swirling structure generates a swirling flow on the air-powder mixture so that the powder is fully atomized to increase the absorption rate of the powder.
  • the combined structure for inhalation administration of this embodiment includes a medicine box and an inhalation administration device.
  • the inhalation drug delivery device is used to suck the powder in the medicine box.
  • the structure of the medicine box of this embodiment will be described in detail below.
  • the medicine box of this embodiment includes a box body 3 and a medicine powder containing body.
  • the powder containing body is arranged in the box body 3 and is provided with a powder containing cavity for placing the powder.
  • the powder accommodating cavity includes a first opening of the powder accommodating cavity for introducing airflow and a second opening of the powder accommodating cavity for outputting a mixture of air and powder.
  • the box body 3 is provided with an air inlet 3A for introducing outside air into the box body 3 and an air powder outlet 3B for outputting an air powder mixture.
  • the medicinal powder accommodating body is movably disposed relative to the box body 3 so that the medicinal powder accommodating cavity is switched between a closed state and an open state.
  • the box body 3 seals the first opening of the powder containing cavity and the second opening of the powder containing cavity.
  • the first opening of the powder accommodating cavity is in communication with the air inlet 3A
  • the second opening of the powder accommodating cavity is in communication with the air powder outlet 3B, so that the powder can interact with the inlet of the air inlet under the suction force of the air powder outlet. The outside air is sucked out from the fan outlet together.
  • the medicinal powder accommodating body is rotatably disposed relative to the box body 3 so that the medicinal powder accommodating cavity can be switched between a closed state and an open state.
  • the medicinal powder containing body is rotatably arranged relative to the box body so that the volume of the medicine box is small, which is convenient for storage and carrying.
  • the powder accommodating cavity may be arranged in a radial direction, or may be arranged in an axial direction, or may be arranged at an angle to the radial direction or an angle to the axial direction, for example.
  • the medicinal powder containing body is coaxially and rotatably arranged relative to the box body 3.
  • the box body 3 includes an annular box body.
  • the ring-shaped box body includes a first box body ring wall, a second box body ring wall, and an installation space formed between the first box body ring wall and the second box body ring wall.
  • the air inlet 3A is arranged on the annular wall of the first box body, and the air powder outlet 3B is arranged on the annular wall of the second box body.
  • the powder containing body is arranged in the installation space.
  • the medicinal powder container has a first container ring wall and a second container ring wall.
  • the powder accommodating cavity is located between the ring wall of the first accommodating body and the ring wall of the second accommodating body, the first opening of the powder accommodating cavity is provided on the ring wall of the first accommodating body, and the second opening of the powder accommodating cavity is provided on the ring wall of the second accommodating body on.
  • the first box body ring wall is the box body ring wall 31 located at the radial inner side of the ring box body.
  • the second box body ring wall is the box body ring wall 32 located on the radially outer side of the ring box body.
  • the first box body ring wall may be located radially outside of the ring box body, and the second box body ring wall may be located radially inside the ring box body.
  • the air inlet 3A and the air powder outlet 3B are arranged in the same direction in the radial direction of the box body 3.
  • the powder containing cavity extends along the radial direction of the powder containing body.
  • the powder containing body is controlled to rotate relative to the box body 3 to make the powder containing cavity communicate with the air inlet and the air powder outlet.
  • the powder containing body is controlled to rotate relative to the box body 3 so that the powder containing cavity rotates to a position closed by the box body 3.
  • the annular box body further includes a first end wall 33 arranged on the annular wall 31 of the box body.
  • the powder containing body is rotatably connected to the first end wall 33 and the first end
  • the wall 33 and the inner wall 31 of the box form an air inlet cavity communicating with the air inlet 3A.
  • the arrangement of the air inlet cavity allows a space between the external space of the inhalation and drug delivery combination structure and the air inlet 3A, which facilitates the installation of accessories such as a filter structure and a flow sharing structure.
  • the ring-shaped box body includes a second end wall 34 disposed between the inner ring wall 31 and the outer ring wall 32 of the box body.
  • the ring wall 31 inside the box, the ring wall 32 outside the box and the second end wall 34 enclose an annular groove, and the annular groove forms an installation space.
  • the second end wall 34 and the first end wall 33 are arranged at both axial ends of the box body 3.
  • the medicinal powder containing body may also be arranged translationally relative to the box body.
  • the medicinal powder containment body and the box body are both square structures, and the medicinal powder containment body is arranged in the box body and can be arranged translationally along the length direction of the box body.
  • the powder containing body includes a first containing part 4 and a second containing part 6.
  • the first accommodating sub-body 4 is provided with a first accommodating sub-cavity
  • the second accommodating sub-body 6 is provided with a second accommodating sub-cavity.
  • the first accommodating part 4 and the second accommodating part 6 are buckled so that the first accommodating cavities and the second accommodating cavities at corresponding positions jointly form a powder accommodating cavity.
  • the powder accommodating body of this embodiment is divided into two accommodating detached bodies that are interlocked with each other to facilitate the dispensing of the powder in the powder accommodating cavity.
  • the powder accommodating cavity in this embodiment is a cylindrical cavity structure.
  • the powder accommodating cavity can also be configured in other shapes, such as a square structure.
  • a connecting post is provided on one of the first accommodating body 4 and the second accommodating body 6 , The other is provided with a connecting hole, and the connecting post is penetrated through the connecting hole so that the first accommodating body 4 and the second accommodating body 6 are tightly buckled with each other.
  • the first accommodating body 4 is provided with both a connecting column and a connecting hole.
  • the second accommodating body 6 is provided with both a connecting column and a connecting hole.
  • the connecting post matched with the connecting hole provided on the receiving split body 4 is also provided with a connecting hole matched with the connecting post provided on the first receiving split body 4. This arrangement makes the assembly between the first accommodating body 4 and the second accommodating body 6 closer.
  • the connecting column in this embodiment has a circular structure, and the connecting hole has a square structure. This arrangement facilitates the combination of the powder container.
  • the first accommodating sub-body 4 of this embodiment has a ring structure and is sleeved on the outside of the ring wall 31 of the box body 3.
  • the second accommodating part 6 is buckled with the first accommodating part 4 and arranged on the first end wall 33.
  • the first end wall 33 is provided with a through hole 33A.
  • the second accommodating body 6 is provided with a rotating shaft 6A, and the rotating shaft 6A penetrates through the through hole 33A to make the second accommodating body 6 rotatable relative to the box body 3, because the first accommodating body 4 and the second accommodating body
  • the split bodies 6 are connected to each other, so that the rotation of the second accommodating split body 6 relative to the box body 3 can drive the first accommodating split body 4 to rotate synchronously.
  • the powder containing body of this embodiment includes more than two powder containing cavities.
  • the two or more powder-containing cavities of the medicine box of this embodiment can contain multiple doses of powder.
  • the patient uses the medicine box of this embodiment for inhalation, he can control the powder-containing body to rotate relative to the box body 3 so that the two More than one medicated powder accommodating cavities are sequentially in an open state, and the medicinal powders in different medicated powder accommodating cavities are sequentially sucked.
  • two or more medicated powder containing cavities can be placed in different types of medicated powder, or the same type of medicated powder can be placed.
  • the medicine box of this embodiment is convenient for patients to take medicine.
  • Figures 5 and 6 schematically show that the powder containing body of the medicine box has seven powder containing cavities.
  • the powder containing body is rotatably arranged relative to the box body 3 so that the seven powder containing cavities are connected to the air inlet 3A and the air powder outlet in sequence. 3B is connected.
  • the inhalation drug delivery device of this embodiment includes a housing and a suction nozzle 16 for installing a medicine box.
  • the casing is provided with the aforementioned vent for introducing external air and a medicine box placing cavity for placing the medicine box.
  • the suction nozzle 16 has an air powder suction port for sucking the powder in the medicine box.
  • the suction nozzle 16 of this embodiment has an air powder suction channel and an air powder suction port 16A disposed at an end of the air powder suction channel away from the medicine box.
  • the housing of this embodiment includes a first housing 1 and a second housing 2.
  • the first housing 1 is provided with a vent 1A for introducing outside air.
  • the second housing 2 has a medicine box placement cavity.
  • the medicine box placement cavity has a first medicine box placement cavity opening 2A communicating with the vent 1A.
  • the first medicine box placement cavity opening 2A communicates with the air inlet 3A of the box body of the medicine box to introduce outside air into the box body 3.
  • the medicine box placement cavity of this embodiment also has a second medicine box placement cavity opening communicating with the air powder suction port. The patient sucks the powder from the wind powder outlet through the wind powder suction channel of the suction nozzle 16.
  • the vent 1A of the first housing 1 of this embodiment is provided with a filtering structure.
  • the opening 2A of the first medicine box placement cavity of the second casing of this embodiment is provided with a flow-sharing structure.
  • the suction nozzle 16 of this embodiment includes a nozzle body 161 and an oral cavity 162 for mounting the suction nozzle 16 on the housing.
  • the oral cavity 162 is provided with the above-mentioned air-powder suction port 16A to provide suction force for sucking the powder.
  • the oral cavity 162 can be sucked into the body by putting the oral cavity 162 into the mouth and inhaling hard.
  • the inhalation drug delivery device of this embodiment further includes a suction nozzle cover 18 provided outside the suction nozzle 16.
  • the inhalation drug delivery device of this embodiment further includes a first swirler arranged between the vent 1A and the medicinal powder accommodating cavity and used to cause the airflow to generate a swirl before the powder is blown.
  • Flow structure 5 in order to fully atomize the medicinal powder, the inhalation drug delivery device of this embodiment further includes a first swirler arranged between the vent 1A and the medicinal powder accommodating cavity and used to cause the airflow to generate a swirl before the powder is blown.
  • the first swirling structure includes an airflow inlet end, an airflow outlet end, and a swirling channel disposed between the airflow inlet end and the airflow outlet end, and the swirling channel includes a flow path from the center of the flow channel.
  • Two or more swirling parts are arranged around the edge of the flow channel in turn, and each swirling part is used to generate a swirling flow of part of the airflow input into it and output it.
  • the first swirling structure causes the airflow to generate a swirling flow before blowing the powder to make the powder fully atomized, thereby increasing the proportion of the powder being inhaled into the lungs.
  • the first swirling structure 5 of this embodiment is arranged upstream of the first opening of the powder containing cavity.
  • the first swirl structure 5 of this embodiment is a circular structure.
  • a first swirling structure 5 is arranged upstream of the first opening of the powder accommodating cavity so that the airflow generates swirl before blowing the powder to increase the suction volume of the powder, thereby increasing the proportion of the powder being inhaled into the lungs.
  • the medicine box of this embodiment includes two or more first swirling structures 5 corresponding to two or more powder containing cavities. To facilitate assembly, two or more first swirl structures 5 can be connected together.
  • the first swirl structure 5 of this embodiment has an air inlet end, an air outlet end, and a swirl channel arranged between the air inlet end and the air outlet end.
  • the swirling channel includes two or more swirling parts arranged sequentially from the radially inner side of the flow channel to the radially outer side of the flow channel, and each swirling part is used to generate a swirling flow of a part of the airflow input into it and output it.
  • two or more swirling parts are arranged in the swirl channel, so that the difference between the radial inner side of the flow channel and the radial outer side of the flow channel of the swirl channel is different.
  • the airflow at different positions can produce swirling flow, so the airflows at different positions in the entire flow channel can produce swirling flow, which increases the suction volume of powder.
  • the first swirling structure 5 of this embodiment includes a first swirling portion 51 and a second swirling portion 52.
  • the directions of the swirling flows generated by the first swirling part 51 and the second swirling part 52 are opposite.
  • the medicine box of this embodiment sets the direction of the swirling flow generated by the adjacent swirling parts to be reversed, so that the airflow before blowing the medicine powder forms a swirling flow of different directions, so that the direction of the impact force on the medicine powder is also different. It can better atomize the medicine powder into a smaller powder, which is easier to be absorbed by the patient.
  • the first swirl structure 5 is arranged at the air inlet 3A.
  • the end surface of the air inlet end of the first swirl structure 5 is in contact with the end surface of the air inlet of the medicine box and is shape-matched.
  • the first swirling structure 5 of this embodiment is arranged at the air inlet 3A of the box body 3.
  • the end surface of the airflow inlet end of the first swirling structure 5 is in contact with the box body 3, and the airflow outlet end of the first swirling structure 5 is The end surface is in contact with the powder containing body.
  • the first swirling structure may also be arranged at other positions on the airflow channel between the vent and the powder containing cavity.
  • the first swirl structure may also be arranged at the opening of the first medicine box placement cavity.
  • the first box body ring wall of the box body 3 has a cylindrical structure. Therefore, as shown in FIG. 8, the end surface of the air inlet end of the first swirl structure 5 is set to protrude toward the air outlet end side. Cylindrical arc structure.
  • the first swirl structure 5 further includes an outer flow guide surface arranged on the outside of the first swirl part counted from the outside of the flow channel.
  • the outer guide surface is an expansion surface that gradually increases from the upstream to the downstream of the swirling channel at least on the side of the air outlet end. The setting of the outer diversion surface as an expanded surface facilitates the airflow to impact the powder located at the cavity wall of the powder containing cavity, thereby reducing the residual powder and increasing the amount of powder entering the patient's oral cavity.
  • the expansion surface includes a tapered surface structure.
  • the adjacent swirling parts of this embodiment are provided between the two adjacent swirling parts. Airflow isolation structure 53.
  • the isolation structure 53 includes a first intermediate flow guide surface for guiding the airflow of the inner swirling part of the two swirling parts for isolation, and two swirling parts for isolating it.
  • the second middle guide surface for guiding the airflow of the middle and outer swirling parts.
  • the first intermediate guide surface at least on the side of the air outlet end is an expansion surface whose cross-sectional area gradually increases from upstream to downstream of the swirl flow channel
  • the second intermediate guide surface is at least on the side of the air outlet end.
  • the cross-sectional area gradually increases from the upstream to the downstream of the swirl flow channel.
  • the arrangement of the expansion surface can also make the air flow impact the powder located on the wall of the powder containing cavity, thereby increasing the amount of powder entering the patient's oral cavity.
  • the inhalation drug delivery device of this embodiment is provided with a first swirl structure to cause the airflow to swirl before blowing the powder to make the powder fully atomized, thereby increasing the proportion of the powder being inhaled into the lungs.
  • the inhalation drug delivery device of this embodiment also includes a device that is arranged between the powder accommodating cavity and the air powder suction port and is used to generate the air powder mixture.
  • the swirling second swirling structure 19 The inhalation drug delivery device of this embodiment is provided with a first swirling structure 5 that generates a swirling flow on the airflow before impacting the powder and a second swirling structure 19 that swirls the wind and powder mixture to fully atomize the powder to improve the powder.
  • the absorption rate is provided with a first swirling structure 5 that generates a swirling flow on the airflow before impacting the powder.
  • the second swirl structure 19 is arranged on the air powder suction channel.
  • the second swirling structure 19 causes the air-powder mixture at the air-powder outlet to generate a swirling flow when passing through the air-powder suction channel and further atomize, thereby improving the atomization effect of the medicinal powder and further improving the patient's absorption rate of the medicinal powder.
  • the second swirling structure 19 includes a swirling passage and swirling vanes arranged in the swirling passage.
  • the air and powder suction channel forms a swirling channel of the second swirling structure.
  • the swirling blade is fixedly arranged relative to the swirling passage. This setting helps to maintain the stability of the amount of powder inhaled each time.
  • the first swirling structure may also include swirling channels and swirling vanes arranged in the swirling channels.
  • the second swirling flow structure may also include an airflow inlet end, an airflow outlet end, and a swirling channel arranged between the airflow inlet end and the airflow outlet end, and the swirling channel includes a flow path from the center to Two or more swirling parts are arranged around the edge of the flow channel in turn, and each swirling part is used to generate a swirling flow of part of the airflow input into it and output it.
  • the suction nozzle 16 of this embodiment further includes an air pipe 15 provided between the nozzle body 161 and the housing.
  • the trachea 15 is connected to the housing through a trachea connecting portion 17.
  • the inner cavity of the trachea 15 forms part of the air powder suction channel.
  • the air pipe 15 is provided with a rectifying structure 151 for rectifying the air and powder mixture.
  • the second swirling structure 19 is arranged downstream of the rectifying structure 151, that is, the rectifying structure 151 is arranged between the first swirling structure 5 and the second swirling structure 19. Therefore, the airflow generates a swirling flow before blowing the powder, and then mixes with the powder to form a wind powder mixture. After the air and powder mixture is formed, the air and powder mixture is rectified through the rectifying structure 151 to make the air and powder mixture flow smoothly in the entire air and powder suction channel, and then the air and powder mixture in the entire air and powder suction channel is processed through the second swirl structure 19 The swirling flow can make more air and powder mixture swirl, so that the powder can be fully atomized.
  • the inhalation drug delivery device of this embodiment further includes a wind powder acceleration channel arranged between the first swirling structure 5 and the second swirling structure 19.
  • the air-powder acceleration channel enables the medicinal powder to be fully accelerated under the driving of the airflow, so that the medicinal powder enters the second swirling structure at a relatively fast speed to effectively disperse the medicinal powder for full atomization.
  • the wind and powder acceleration channel is an acceleration cavity provided between the first swirl structure 5 and the second swirl structure 19.
  • the acceleration cavity provides a space for the acceleration of the powder, so that the powder can have a faster speed when it enters the second swirl structure.
  • the length of the acceleration cavity is greater than or equal to 10 mm.
  • the length of the acceleration cavity is greater than 20 mm.
  • the oral cavity 162 of this embodiment further has a peripheral wind suction port 16B that is provided on the side of the air powder suction port 16A and communicates with the atmosphere to form peripheral wind outside the air powder suction port 16A.
  • the peripheral air suction port 16B is arranged so that peripheral air is formed outside the air powder suction port 16A. Therefore, when the powder passes through the oral cavity, the peripheral air outside the main channel of the powder circulation forms a certain isolation effect on the powder, so that the powder It is more difficult to adhere to the oral cavity wall, so the proportion of powder that enters the lungs is increased.
  • a gas containing space is formed between the first housing 1 and the second housing 2.
  • Part of the gas entering the first housing 1 through the vent 1A of the first housing 1 enters the medicine box through the opening of the first medicine box placement cavity on the second housing, and partly enters the first housing 1 and the second housing In the gas containing space formed between the bodies 2.
  • the suction nozzle 16 is arranged on the housing.
  • the air powder suction port 16A of the suction nozzle 16 communicates with the opening of the second medicine box placement cavity on the second housing through the air powder suction channel to suck the powder.
  • the peripheral wind suction port 16B of the suction nozzle 16 located on the side of the wind powder suction port communicates with the gas storage space to communicate with the atmosphere to form peripheral wind.
  • the filter structure of the first housing 1 is provided with a support portion 1B extending toward the inner side of the first housing 1.
  • the support portion 1B provides a gap between the second housing 2 and the first housing 1. Therefore, the outer surface of the medicine box placement cavity of the second housing 2 and A gas containing space is formed between the first housing 1.
  • the suction nozzle 16 is installed on the housing, the peripheral wind suction port of the suction nozzle 16 can suck the gas in the gas containing space to form the peripheral wind.
  • the oral cavity 162 is provided with at least two peripheral wind suction ports 16B located at different positions in the circumferential direction of the wind powder suction port 16A. This arrangement can increase the outlet point of the surrounding wind and better prevent the powder from sticking to the oral cavity wall.
  • the air powder suction port 16A of this embodiment is provided with two symmetrical sides on both sides. Peripheral wind suction ports 16B.
  • At least two peripheral air suction openings may also be arranged around the air powder suction opening. Such arrangement makes the peripheral wind formed in the circumferential direction of the wind powder suction channel, and prevents the powder from adhering to the oral cavity wall in all directions.
  • the oral cavity 162 includes a suction end surface located on one side of the oral cavity during suction.
  • the air powder suction opening 16A and the peripheral air suction opening 16B are both arranged on the suction end surface.
  • the suction end surface of this embodiment includes a curved surface protruding to the side away from the oral cavity.
  • the curved surface forms a recessed space to facilitate the oral cavity to effectively fit the lips to prevent the side of the oral cavity from showing, and to avoid the tongue as much as possible to prevent the powder from adhering to the oral cavity and the tongue.
  • the curved surface is an arc cylindrical surface.
  • the oral cavity of this embodiment includes two peripheral air suction openings located at both ends of the air powder suction opening, and The center of the wind suction port and the center of the wind powder suction port are both located on the same straight line parallel to the generatrix of the arc cylindrical surface.
  • the inhalation drug delivery device of this embodiment includes a driving mechanism for driving the powder container to move relative to the box body 3.
  • the driving mechanism includes a pawl plate 9 rotatable relative to the box body 3.
  • the pawl plate 9 is provided with a pawl plate pawl 91.
  • the medicine powder container is provided with container ratchets.
  • the pawl disc pawl 91 drives the ratchet tooth of the container to rotate to drive the powder container to rotate.
  • a container ratchet 61 is provided on the top surface of the second container body 6 of the powder container.
  • the pawl plate 9 equipped with the pawl plate pawl 91 is installed on the mounting plate 7 and cooperates with the container ratchet provided on the powder container to drive the second container body 6 to rotate.
  • the second accommodating body 6 is connected to the first accommodating body 4, so the first accommodating body 4 can also rotate synchronously with the second accommodating body 6 to realize the rotation of the powder accommodating body.
  • the mounting plate 7 is provided with a plurality of connecting bars 71 arranged at intervals in the circumferential direction.
  • a plurality of connecting protrusions 92 are provided on the pawl plate 9. The connecting bar 71 is clamped between the two connecting protrusions 92 to install the pawl plate on the mounting plate 7.
  • the combined structure for inhalation and drug delivery in this embodiment further includes a turntable 13 provided with a knob.
  • the pawl plate 9 is connected with the turntable 13 to rotate synchronously under the drive of the turntable 13.
  • the pawl of the turntable can be directly matched with the ratchet teeth of the container to drive the powder container to rotate.
  • the inhalation drug delivery device of this embodiment further includes an information display structure for displaying the use information of the medicine box.
  • the powder containing body includes more than two powder containing cavities.
  • the information display structure includes two or more flag plates 8 corresponding to two or more powder containing cavities.
  • the marking disc 8 rotates synchronously with the powder containing body.
  • the combined structure of inhalation drug delivery in this embodiment includes a marker disk 8 and a turntable outer ring 10.
  • the turntable outer ring 10 is fixedly arranged relative to the box body 3.
  • a window 10A is provided on the outer ring 10 of the turntable.
  • the marking plate 8 is provided on the lower side of the outer ring 10 of the turntable.
  • the window 10A can display the marks on the sign disc 8 while the sign disc 8 is rotating.
  • the turntable 13 is arranged in the middle of the outer ring 10 of the turntable, and an arrow is provided on the outer ring 10 to show the direction in which the turntable 13 rotates.
  • the index plate 8 is provided with counting marks corresponding to more than two powder containing cavities.
  • the marking plate 8 rotates synchronously with respect to the powder containing body to display the usage of the powder in the multiple powder containing cavities in the powder containing body.
  • the medicine box of this embodiment there are seven medicine powder containing chambers.
  • the count mark on the mark plate 8 is displayed as zero.
  • the counting mark of the marking plate 8 gradually becomes larger.
  • the patient can know that the powder in the medicine box has been used up, and can replace the medicine box with a new one.
  • the setting of the indicator disc 8 makes the combined structure of inhalation and administration of this embodiment more convenient to use.
  • the mark on the mark disc may also include the use information of the medicine box such as the powder type information.
  • the mark on the marking plate may be the powder type information corresponding to the type of medicated powder in the medicated powder containing chamber.
  • a sign disc ratchet is provided on the inner edge of the sign disc 8.
  • the turntable 13 is provided with a turntable pawl 131.
  • the pawl 131 of the turntable cooperates with the ratchet teeth of the sign disc to drive the ratchet teeth of the sign disc to rotate.
  • the turntable 13 drives the pawl disc 9 to rotate synchronously, so that the sign disc 8 and the powder containing body rotate synchronously, so that the counting marks on the sign disc 8 can be It shows the state of use of the powder containing cavity of the powder containing body.
  • the combined structure for inhalation administration further includes an elastic element 12 for automatically returning the pawl of the turntable.
  • the first end of the elastic element 12 and the turntable 13 are relatively fixedly arranged.
  • the second end of the box 3 is relatively fixedly arranged.
  • the bottom of the turntable 13 is provided with a first connecting groove 13A, and the first end of the elastic element 12 is connected in the first connecting groove 13A.
  • the combined structure of inhalation drug delivery in this embodiment further includes a limiting disk 11 fixedly arranged relative to the box body 3.
  • a second connecting groove 11B is provided on the limit disk 11.
  • the second end of the elastic element 12 is connected to the second connecting groove 11B. Since the first end of the elastic element 12 is fixedly connected to the turntable 13 and the second end of the elastic element 12 is fixedly connected to the limit disk 11, the turntable 13 can automatically return under the pulling of the elastic element 12 after rotating.
  • the elastic element 12 is a torsion spring.
  • the limit disk 11 of this embodiment is provided with a limit slot 11A.
  • a limiting protrusion 132 is provided on the turntable 13. The limiting protrusion 132 swings in the limiting slot 11A to limit the rotation range of the turntable pawl 131 each time.
  • the limit disk of this embodiment is provided with two limit grooves arranged symmetrically.
  • the two limiting grooves respectively cooperate with the two limiting protrusions on the turntable 13.
  • the driving mechanism of this embodiment is provided with a turntable 13 and a pawl plate 9 that rotates synchronously with the turntable 13 so that the turntable pawls on the turntable 13 drive the sign plate 8 to rotate while the turntable 13 drives the powder containing body to rotate, thereby realizing the sign plate 8 Display of the powder usage status of the powder container.
  • a knob is provided on the turntable 13 to facilitate the operation of the patient.
  • the first preparation and the second preparation were used to test the powder suction effect of the medicine box with the first swirl structure and the powder suction effect of the medicine box without the first swirl structure.
  • the test results are shown in the table 1 shown.
  • the powder particle diameter of the first preparation is 10 ⁇ m.
  • the diameter of the powder particles of the second preparation is 2.8 ⁇ m.
  • the powder suction volume of the medicine box with the first swirl structure is greater than that without the first swirl structure.
  • the powder suction volume of the medicine box with flow structure it can be seen that the provision of the first swirl structure can increase the amount of powder that is sucked out of the medicine box.
  • the mass average aerodynamic diameter of the powder sucked by the medicine box with the second swirl structure is smaller than that of the medicine box without the second swirl structure.
  • the mass average aerodynamic diameter of the powder is larger than that of the medicine box without the second swirl structure.
  • the proportion of the average aerodynamic diameter of the corresponding mass in the powder is larger.
  • the inhalation drug delivery device of the embodiments of the present disclosure has at least the following advantages:
  • the first swirling structure is arranged in the medicine box to increase the suction volume of the medicine powder.
  • the second swirl structure is provided to improve the atomization effect of the powder, thereby increasing the amount of powder inhaled by the patient.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un dispositif d'administration par inhalation et une structure d'administration combinée par inhalation. Le dispositif d'administration par inhalation comprend une ouverture de ventilation (1A) pour introduire de l'air externe, une cavité de mise en place de boîte de médicament pour la mise en place d'une boîte de médicament, et une ouverture d'aspiration de poudre d'air (16A) pour aspirer une poudre de médicament dans une cavité de logement de poudre de médicament de la boîte de médicament, et le dispositif d'administration par inhalation comprend en outre une première structure d'écoulement rotationnel (5) disposée entre l'ouverture de ventilation (1A) et la cavité de logement de poudre de médicament et utilisée pour générer un flux de rotation avant qu'un flux d'air souffle la poudre de médicament. La première structure d'écoulement rotationnel (5) du dispositif d'administration par inhalation génère le flux de rotation avant que le flux d'air souffle la poudre de médicament, de sorte que le flux d'air peut plus efficacement souffler la poudre de médicament hors de la cavité de logement de poudre de médicament, optimisant ainsi l'effet d'aspiration de la poudre de médicament.
PCT/CN2019/100241 2019-08-12 2019-08-12 Dispositif d'administration par inhalation et structure d'administration combinée par inhalation WO2021026733A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/100241 WO2021026733A1 (fr) 2019-08-12 2019-08-12 Dispositif d'administration par inhalation et structure d'administration combinée par inhalation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/100241 WO2021026733A1 (fr) 2019-08-12 2019-08-12 Dispositif d'administration par inhalation et structure d'administration combinée par inhalation

Publications (1)

Publication Number Publication Date
WO2021026733A1 true WO2021026733A1 (fr) 2021-02-18

Family

ID=74569341

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/100241 WO2021026733A1 (fr) 2019-08-12 2019-08-12 Dispositif d'administration par inhalation et structure d'administration combinée par inhalation

Country Status (1)

Country Link
WO (1) WO2021026733A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048953B2 (en) * 2000-04-03 2006-05-23 Inhalation, Inc. Methods and apparatus to prevent, treat and cure infections of the human respiratory system by pathogens causing severe acute respiratory syndrome (SARS)
CN101437562A (zh) * 2006-03-03 2009-05-20 Stc.Unm公司 具有气动力弹性分散机构的干粉吸入器
CN101642735A (zh) * 2009-03-18 2010-02-10 陈久斌 雾化器
CN102688224A (zh) * 2003-04-14 2012-09-26 维克特拉有限公司 用于提高剂量效率的药物组合物和装置
CN107432967A (zh) * 2016-05-26 2017-12-05 兰州大学第医院 一种新型多功能雾化吸入装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048953B2 (en) * 2000-04-03 2006-05-23 Inhalation, Inc. Methods and apparatus to prevent, treat and cure infections of the human respiratory system by pathogens causing severe acute respiratory syndrome (SARS)
CN102688224A (zh) * 2003-04-14 2012-09-26 维克特拉有限公司 用于提高剂量效率的药物组合物和装置
CN101437562A (zh) * 2006-03-03 2009-05-20 Stc.Unm公司 具有气动力弹性分散机构的干粉吸入器
CN101642735A (zh) * 2009-03-18 2010-02-10 陈久斌 雾化器
CN107432967A (zh) * 2016-05-26 2017-12-05 兰州大学第医院 一种新型多功能雾化吸入装置

Similar Documents

Publication Publication Date Title
JP4335666B2 (ja) 粉末吸入器
EP0640354B1 (fr) Inhalateur pour poudres à tourbillon
AU2008341216B2 (en) Device and method for deaggregating powder 854
JP5297719B2 (ja) 解凝集装置
FI107126B (fi) Jauheinhalaattori yhdistelmälääkkeelle
CN102228725B (zh) 一种干粉给药装置
HU220450B1 (hu) Inhalálókészülék száraz porok inhalálásához
BG99579A (bg) Инхалатор за сухо прахообразно вещество
PL176849B1 (pl) Inhalator do substancji proszkowych
PT1294421E (pt) Inalador de pó seco
BR0017519B1 (pt) cápsula de medicamento para um inalador, e processo para fabricação de uma cápsula compreendendo um medicamento em pó.
JP2009537199A (ja) 簡易吸入器
JP2000202028A (ja) 吸入式投薬器
JP2008500851A (ja) ユニット投与ドライパウダー吸入器
US20140137862A1 (en) Dry Powder Drug-dosing Device
US20160367770A1 (en) Oral inhaler mixer system and method
JP3488620B2 (ja) 吸入式投薬器
WO2021026733A1 (fr) Dispositif d'administration par inhalation et structure d'administration combinée par inhalation
CN110201279B (zh) 用于吸入给药的药盒和吸入给药组合结构
US6237591B1 (en) Turbine dry powder inhaler
CN110201278B (zh) 用于吸入给药的药盒和吸入给药组合结构
CN110201281B (zh) 吸入给药装置和吸入给药组合结构
CN110201280B (zh) 用于吸入给药装置的吸嘴和吸入给药装置
JP2016523823A (ja) 吸入可能な医薬組成物およびこれを含む吸入器デバイス
CN110064110A (zh) 一种容积旋钮式干粉储存吸入装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19941179

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19941179

Country of ref document: EP

Kind code of ref document: A1

122 Ep: pct application non-entry in european phase

Ref document number: 19941179

Country of ref document: EP

Kind code of ref document: A1

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 07/10/2022)

122 Ep: pct application non-entry in european phase

Ref document number: 19941179

Country of ref document: EP

Kind code of ref document: A1