WO2021010548A1 - Appareil pour fabriquer un matériau de greffe osseuse alloplastique - Google Patents

Appareil pour fabriquer un matériau de greffe osseuse alloplastique Download PDF

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Publication number
WO2021010548A1
WO2021010548A1 PCT/KR2019/016446 KR2019016446W WO2021010548A1 WO 2021010548 A1 WO2021010548 A1 WO 2021010548A1 KR 2019016446 W KR2019016446 W KR 2019016446W WO 2021010548 A1 WO2021010548 A1 WO 2021010548A1
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WO
WIPO (PCT)
Prior art keywords
bone graft
reaction chamber
synthetic bone
graft material
impeller
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Application number
PCT/KR2019/016446
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English (en)
Korean (ko)
Inventor
윤계림
노학
Original Assignee
주식회사 휴덴스
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Publication of WO2021010548A1 publication Critical patent/WO2021010548A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0086—Processes carried out with a view to control or to change the pH-value; Applications of buffer salts; Neutralisation reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0004—Consolidating natural teeth
    • A61C8/0006—Periodontal tissue or bone regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/0013—Controlling the temperature of the process
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B01J19/0066—Stirrers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00481—Means for mixing reactants or products in the reaction vessels by the use of moving stirrers within the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00698—Measurement and control of process parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00745—Inorganic compounds

Definitions

  • the present invention relates to an apparatus for manufacturing a synthetic bone graft material, and more specifically, a calcium phosphate-based synthesis that has different thermodynamic properties depending on the ratio of calcium and phosphorus (Ca/P), and shows a difference in solubility in a human body or a solution similar to that of the human body. It relates to a synthetic bone graft manufacturing apparatus capable of mass-producing a bone graft material in a simple, rapid, and high purity manner.
  • bone graft materials are materials used to regenerate and reinforce bones that have been absorbed or destroyed due to inflammation, aging, or trauma, and are mainly used after tooth extraction or during implant procedures, and bone graft materials are used depending on the origin of the material. It is classified into autogenous bone, allogeneic bone, heterogeneous bone, and synthetic bone.
  • the synthetic bone can be defined as'artificial synthetic bone that can be used to repair or rebuild tissue and can be processed by heat or pressure', and it is inexpensive and there is no limit on the size of the material.
  • the scope of application is diverse.
  • each calcium phosphate-based synthetic bone has different thermodynamic properties according to the ratio of calcium and phosphorus, and shows a difference in solubility in a human body or a solution similar to that of the human body.
  • Ca/P monocalcium phosphate
  • the calcium phosphate-based synthetic bone has excellent hydrophilicity and is helpful for cell adhesion or proliferation, and monovalent ions such as Na + , K + , Li +, etc. or Sr 2+ , Ba 2+ , Pb 2+ , Mn 2+ , Sn 2+ , Zn 2+, or the like, replacement with divalent ions, Al 3+ ions, or defects can change the material properties.
  • high-temperature treatment may be performed, and during high-temperature heat treatment, some calcium phosphate-based synthetic bones cause volatilization of phosphate, resulting in a phase transition to a material with low Ca/P.
  • the octacalcium phosphate is a calcium phosphate-based ceramic with a calcium and phosphorus ratio of 1.33, and its dissolution property is neither too fast nor too slow, so it plays a role as bone cement well until new bones grow, and after new bones grow, It partially dissolves and disappears, creating an environment in which new bones can grow well, and has good cell adhesion and non-cytotoxicity, and the results of test-tube and animal experiments are very excellent, which is attracting attention as a synthetic bone graft material.
  • the OCP has a property of easily changing into another material by pH, it is difficult to synthesize high-purity OCP in large quantities, and thus, there is a problem that it has not been distributed in the biomaterial market yet.
  • the present invention was invented to solve the above-described problems, and it is an object of the present invention to provide a synthetic bone graft material manufacturing apparatus capable of mass-producing a synthetic bone graft material, in particular, a calcium phosphate-based synthetic bone graft material including OCP in a simple, rapid and high purity manner. To do.
  • Another object is to provide a synthetic bone graft manufacturing apparatus capable of controlling the crystal phase of the synthetic bone graft material produced by precisely controlling the stirring speed, temperature and pH in the reaction process of the raw material.
  • the apparatus for manufacturing a synthetic bone graft material includes a reaction chamber for reacting by introducing a raw material of the synthetic bone graft material, and a drive provided on the top of the reaction chamber and provided with a vertical rotation axis.
  • a motor at least one impeller connected to the rotation shaft to stir and react the raw material of the synthetic bone graft material injected into the reaction chamber, a synthetic bone graft material provided on the upper side of the reaction chamber and reacted inside the reaction chamber
  • At least one pH meter for measuring the pH of raw materials, an acidic material injection port and an alkaline material injection port for controlling the crystal phase of the synthetic bone graft material, which is provided on the upper part of the reaction chamber and controls the pH of the synthetic bone graft material
  • a heating means for controlling the crystal phase of the synthetic bone graft material produced by heating the synthetic bone graft raw material injected into the reaction chamber on the outer circumferential surface of the reaction chamber.
  • the reaction chamber may have an aspect ratio of 2:1 or 3:1.
  • reaction chamber Preferably, it is provided under the reaction chamber and may include a valve for discharging the synthetic bone graft material in which the reaction has been completed.
  • the heating means may be any one selected from the group consisting of a hot wire heater, a hot water heater, and an oil heater.
  • the impeller includes an upper impeller, an intermediate impeller, and a lower impeller, and the upper impeller, the intermediate impeller, and the lower impeller may be provided on the rotation shaft at equal intervals.
  • the pitch angle of the upper impeller is formed to generate a downward vortex according to rotation
  • the pitch angle of the lower impeller is formed to generate a rising vortex according to rotation
  • the pitch angle of the intermediate impeller is Accordingly, it may be formed to simultaneously generate an upward vortex and a downward vortex.
  • the pH meter may be provided at the upper, middle and lower portions of the reaction chamber, respectively.
  • a pressure measuring device for measuring the internal pressure of the reaction chamber may be provided above the reaction chamber.
  • a temperature measuring device for measuring the internal temperature of the reaction chamber may be provided above the reaction chamber.
  • a pressurized gas injection port is provided on the upper part of the reaction chamber, and the pressurized gas injected through the pressurized gas injection port may block evaporation of the synthetic bone graft raw material injected into the reaction chamber.
  • the synthetic bone graft manufacturing site can manufacture a synthetic bone graft material, in particular, a calcium phosphate-based synthetic bone graft material including OCP in a simple, rapid, and high-purity mass manner.
  • the synthetic bone graft manufacturing site has an excellent effect of controlling the crystal phase of the synthetic bone graft material produced by precisely controlling the stirring speed, temperature and pH in the reaction process of the raw material.
  • FIG. 1 is a perspective view showing the overall configuration of a synthetic bone graft manufacturing site according to an embodiment of the present invention.
  • Figure 2 is a side view of the synthetic bone graft manufacturing plant shown in Figure 1;
  • the present invention relates to an apparatus for manufacturing a synthetic bone graft material, and more specifically, a reaction chamber for reacting by introducing a raw material for a synthetic bone graft material;
  • a drive motor provided above the reaction chamber and having a vertical rotation shaft;
  • At least one impeller connected to the rotation shaft to stir and react the raw material of the synthetic bone graft material injected into the reaction chamber;
  • At least one pH meter provided above the reaction chamber and configured to measure the pH of the raw material of the synthetic bone graft material reacted in the reaction chamber;
  • An acid material injection port and an alkali material injection port provided on the upper part of the reaction chamber and for controlling a crystal phase of the synthetic bone graft material produced by adjusting the pH of the synthetic bone graft material;
  • a heating means for controlling the crystal phase of the synthetic bone graft material produced by heating the raw material of the synthetic bone graft material injected into the reaction chamber on the outer circumferential surface of the reaction chamber.
  • FIG. 1 is a perspective view showing the overall configuration of a synthetic bone graft manufacturing plant according to an embodiment of the present invention
  • FIG. 2 is a side view of the synthetic bone graft manufacturing plant shown in FIG. 1.
  • an apparatus 100 for manufacturing a synthetic bone graft material includes a reaction chamber 110 for reacting raw materials for a synthetic bone graft material.
  • the reaction chamber 110 is a space in which the raw material of the synthetic bone graft material is input and reacts, and may be formed in various shapes. In one embodiment of the present invention, the reaction chamber 110 has a cylindrical shape.
  • reaction chamber 110 may be made of various materials, but in an embodiment of the present invention, the reaction chamber 110 is made of transparent glass so that the reaction process inside can be visually confirmed.
  • the reason for limiting the reaction chamber 110 to transparent glass in an embodiment of the present invention is as follows.
  • the raw material of the synthetic bone graft material is introduced into the reaction chamber in a liquid state.
  • the thermal conductivity of the raw material of the synthetic bone graft material is about 0.6 W/mK and about 1.1 W/mK in the case of glass.
  • the difference in thermal conductivity between the raw material of the synthetic bone graft material and the glass is about 0.5.
  • the thermal conductivity of stainless steel is about 12 to 45 W/m.K, and the difference from the thermal conductivity of the raw material of the synthetic bone graft material is severe, making precise temperature control difficult.
  • the coefficient of thermal expansion is about 8.1 ⁇ 10 -5 /°C, so that the influence on the quality of the product can be minimized.
  • the synthetic bone graft manufacturing apparatus 100 minimizes the difference in thermal conductivity between the raw material of the synthetic bone graft material and the reaction chamber 110 as described above, thereby enabling precise reaction temperature control and thermal expansion. Glass is used to minimize the deterioration of product quality due to counting.
  • reaction chamber 110 of the apparatus 100 for manufacturing a synthetic bone graft material has an aspect ratio, that is, a vertical to horizontal ratio of 2:1 or 3:1.
  • the reason for limiting the aspect ratio of the reaction chamber 110 to 2:1 or 3:1 is as follows.
  • a synthetic bone graft raw material is injected into the reaction chamber 110, and the injected synthetic bone graft raw material is heated by a heating means 150 to be described later.
  • the raw material of the synthetic bone graft material is evaporated by heating the heating means 150 and the evaporation amount is proportional to the horizontal cross-sectional area of the reaction chamber 110.
  • the evaporation of the raw material of the synthetic bone graft material causes a difference in concentration between the surface where evaporation occurs and the lower portion where evaporation does not occur. It becomes difficult.
  • the reaction chamber 110 limited the aspect ratio of the reaction chamber 110 to 2:1 or 3:1 in order to minimize the evaporation amount of the raw material for the synthetic bone graft material.
  • the synthetic bone graft raw material may be introduced into the reaction chamber 110 by opening and closing the upper portion of the reaction chamber 110. As shown in FIG. It may be inserted by providing an inlet 115 for inputting raw materials of the synthetic bone graft material at the top.
  • the apparatus 100 for manufacturing a synthetic bone graft material includes a driving motor 120 provided on the reaction chamber 110 and having a vertical rotation shaft 121.
  • the driving motor 120 is a configuration for rotating the impeller (122) (122a) (122b) (122c) for the stirring reaction of the raw material of the synthetic bone graft material, and various types of driving motors may be used.
  • the drive motor uses a step motor that facilitates precise control of RPM.
  • the synthetic bone graft manufacturing apparatus 100 is at least for reacting by stirring the raw material of the synthetic bone graft material that is connected to the rotation shaft 121 and introduced into the reaction chamber 110. It includes one or more impellers 122.
  • the impeller 122 may be provided in an appropriate number as needed, but in an embodiment of the present invention, as shown in FIG. 2, an upper impeller 122a, an intermediate impeller 122b, and a lower impeller ( 122c) consists of a total of three, and the three impellers 122a, 122b, and 122c are provided on the same rotation shaft 121 at equal intervals.
  • the impeller 122 has the following structural features, and will be described in detail below.
  • the three impellers 122a, 122b, and 122c each have two rotating blades, and at this time, the pitch angle of the upper impeller 122a generates a downward vortex according to rotation.
  • the pitch angle of the lower impeller 122c is formed to generate a rising vortex according to rotation, and the pitch angle of the intermediate impeller 122b is formed to simultaneously generate a rising vortex and a falling vortex according to rotation.
  • the raw material of the synthetic bone graft material is flowed as shown in FIG. 2.
  • the stirring speed of the synthetic bone graft manufacturing apparatus 100 is characterized in that the stirring is 1 ⁇ 300RPM, more preferably 30 ⁇ 60RPM.
  • the synthetic bone graft manufacturing apparatus 100 can maximize the reaction efficiency of the synthetic bone graft raw material by stirring the raw material at a low RPM.
  • impeller 122 and the rotation shaft 121 may be made of various materials, but in an embodiment of the present invention, it is made of Teflon to improve corrosion resistance.
  • the synthetic bone graft manufacturing apparatus 100 is provided above the reaction chamber 110 and measures the pH of the synthetic bone graft raw material reacted inside the reaction chamber 110 At least one pH meter 130 is provided for this.
  • the synthetic bone graft manufacturing apparatus 100 includes the pH meter 130 at the inner upper part of the reaction chamber. It is provided in (130a), the middle part (130b), and the lower part (130c), respectively.
  • the synthetic bone graft manufacturing apparatus 100 has three pH meters 130 (130a) (130b) (130c) as described above, and the pH value is calculated as an average value thereof. By calculating, it is possible to precisely control the pH in the manufacturing process of the synthetic bone graft material.
  • the synthetic bone graft manufacturing apparatus 100 is provided above the reaction chamber 110 and controls the crystal phase of the synthetic bone graft material manufactured by adjusting the pH of the raw material of the synthetic bone graft material. It includes an acidic material injection port 111 and an alkaline material injection port 112 for.
  • the raw material of the synthetic bone graft material changes its pH depending on the reaction temperature or time during the reaction process, and it is necessary to continuously maintain and control the selected pH in order to manufacture the synthetic bone graft material having a specific crystal phase.
  • an acidic substance injection hole 111 and an alkaline substance injection hole 112 are provided at the upper portion of the reaction chamber 110, and the pH measured through the pH meter 130 is used.
  • An acidic substance or an alkaline substance is injected to maintain the selected pH or control the crystal phase.
  • OCP octacalcium phosphate
  • the synthetic bone graft manufacturing apparatus 100 is provided under the reaction chamber 110 and includes a valve 140 for discharging the reaction-completed synthetic bone graft material. .
  • the synthetic bone graft raw material is deposited in the lower part of the reaction chamber 110 in the form of a precipitate.
  • the synthetic bone graft manufacturing apparatus 100 has the valve 140 in order to simply obtain the synthetic bone graft material deposited in the lower portion of the reaction chamber 110, and the valve ( The synthetic bone graft material manufactured by opening 140) is discharged to the outside of the reaction chamber 110.
  • Synthetic bone graft manufacturing apparatus 100 not only can simply obtain the synthetic bone graft material deposited in the lower portion through the above-described valve 140, the manufactured synthetic bone graft material is discharged There is also an effect that the raw material of the synthetic bone graft material remaining in the reaction chamber 110 can be reused.
  • valve 140 may use all of the valves in various ways, there is no particular limitation on this.
  • the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention, as shown in FIG. 1, the synthetic bone graft raw material injected into the reaction chamber 110 on the outer circumferential surface of the reaction chamber 110. It includes a heating means 150 for controlling the crystal phase of the synthetic bone graft material produced by heating.
  • the outer circumferential surface means the side and lower surfaces of the reaction chamber 110 in a cylindrical shape, through which the raw material of the synthetic bone graft material is uniformly heated.
  • the heating means 150 may be provided as a hot wire heater, and in another embodiment, a hot water heater using hot water supplied through a pipe surrounding the outer circumferential surface or an oil heater using heated oil. It can also be made of.
  • the synthetic bone graft manufacturing apparatus 100 is a pressure measuring device 160 and the reaction chamber for measuring the internal pressure of the reaction chamber 110 on the upper portion of the reaction chamber 110.
  • a temperature measuring device 170 for measuring the internal temperature of 110 is provided.
  • the reaction conditions of the raw material of the synthetic bone graft material may be monitored and controlled through the pressure measuring device 160 and the temperature measuring device 170.
  • the synthetic bone graft manufacturing apparatus 100 is provided with a pressurized gas injection port 113 on the upper part of the reaction chamber 110, and pressurized injected through the pressurized gas injection port 113
  • the gas is filled in the upper empty space of the reaction chamber 110 into which the raw material of the synthetic bone graft material is injected and serves to block the evaporation of the raw material of the synthetic bone graft material.
  • the pressurized gas is an inert gas such as argon (Ar), neon (Ne), helium (He), nitrogen (N) and carbon dioxide (CO 2 ), and the reaction chamber 110 using the pressurized gas It is preferable that the internal pressure is 0.2 to 0.6 MPa.
  • the pressurized gas may be discharged through the pressurized gas inlet 113 after the synthetic bone graft reaction is completed, but in another embodiment, a separate pressurized gas outlet 114 at the upper portion of the reaction chamber 110 It may be discharged through it by having.
  • the synthetic bone graft manufacturing apparatus 100 can produce a synthetic bone graft material, in particular, a calcium phosphate-based synthetic bone graft material including OCP in a simple, fast and high-purity mass manner through the above-described technical configurations.
  • the synthetic bone graft manufacturing plant according to an embodiment of the present invention has an excellent effect of controlling the crystal phase of the synthetic bone graft material produced by precisely controlling the stirring speed, temperature and pH in the reaction process of the raw material.
  • the present invention relates to an apparatus for manufacturing a synthetic bone graft material, and more specifically, a calcium phosphate-based synthesis that has different thermodynamic properties depending on the ratio of calcium and phosphorus (Ca/P), and shows a difference in solubility in a human body or a solution similar to that of the human body.
  • the bone graft material can be manufactured in large quantities with simple, rapid and high purity, and thus has industrial applicability.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Dentistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne un appareil pour fabriquer un matériau de greffe osseuse alloplastique et, plus spécifiquement, est caractérisé en ce qu'il comprend : une chambre de réaction pour injecter et faire réagir une matière première d'un matériau de greffe osseuse alloplastique ; un moteur d'entraînement disposé au-dessus de la chambre de réaction et comprenant un arbre de rotation vertical ; au moins une turbine reliée à l'arbre de rotation de manière à agiter et à faire réagir la matière première du matériau de greffe osseuse alloplastique injecté dans la chambre de réaction; au moins un pH situé au-dessus de la chambre de réaction et pour mesurer le pH de la matière première du matériau de greffe osseuse alloplastique ayant réagi dans la chambre de réaction ; un orifice d'injection de matériau acide et un orifice d'injection de matériau alcalin disposé au-dessus de la chambre de réaction et pour contrôler une phase cristalline du matériau de greffe osseuse alloplastique fabriqué par ajustement du pH du matériau de greffe osseuse alloplastique ; et un moyen de chauffage, sur la surface circonférentielle externe de la chambre de réaction, pour contrôler la phase cristalline du matériau de greffe osseuse alloplastique fabriqué par chauffage de la matière première du matériau de greffe osseuse alloplastique injecté dans la chambre de réaction.
PCT/KR2019/016446 2019-07-12 2019-11-27 Appareil pour fabriquer un matériau de greffe osseuse alloplastique WO2021010548A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2019-0084131 2019-07-12
KR1020190084131A KR102094987B1 (ko) 2019-07-12 2019-07-12 합성골 이식재 제조장치

Publications (1)

Publication Number Publication Date
WO2021010548A1 true WO2021010548A1 (fr) 2021-01-21

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