WO2021010548A1

WO2021010548A1 - Apparatus for manufacturing alloplastic bone graft material

Info

Publication number: WO2021010548A1
Application number: PCT/KR2019/016446
Authority: WO
Inventors: 윤계림; 노학
Original assignee: 주식회사 휴덴스
Priority date: 2019-07-12
Filing date: 2019-11-27
Publication date: 2021-01-21
Also published as: KR102094987B1

Abstract

The present invention relates to an apparatus for manufacturing an alloplastic bone graft material and, more specifically, is characterized by comprising: a reaction chamber for injecting and reacting a raw material of an alloplastic bone graft material; a drive motor provided above the reaction chamber and having a vertical rotation shaft; at least one impeller connected to the rotation shaft so as to stir and react the raw material of the alloplastic bone graft material injected into the reaction chamber; at least one pH meter provided above the reaction chamber and for measuring the pH of the raw material of the alloplastic bone graft material reacted in the reaction chamber; an acidic material injection port and an alkaline material injection port provided above the reaction chamber and for controlling a crystal phase of the alloplastic bone graft material manufactured by adjusting the pH of the alloplastic bone graft material; and a heating means, on the outer circumferential surface of the reaction chamber, for controlling the crystal phase of the alloplastic bone graft material manufactured by heating the raw material of the alloplastic bone graft material injected into the reaction chamber.

Description

Synthetic bone graft manufacturing device

The present invention relates to an apparatus for manufacturing a synthetic bone graft material, and more specifically, a calcium phosphate-based synthesis that has different thermodynamic properties depending on the ratio of calcium and phosphorus (Ca/P), and shows a difference in solubility in a human body or a solution similar to that of the human body. It relates to a synthetic bone graft manufacturing apparatus capable of mass-producing a bone graft material in a simple, rapid, and high purity manner.

In general, bone graft materials, especially dental bone graft materials, are materials used to regenerate and reinforce bones that have been absorbed or destroyed due to inflammation, aging, or trauma, and are mainly used after tooth extraction or during implant procedures, and bone graft materials are used depending on the origin of the material. It is classified into autogenous bone, allogeneic bone, heterogeneous bone, and synthetic bone.

Among them, the synthetic bone (Alloplastic bone) can be defined as'artificial synthetic bone that can be used to repair or rebuild tissue and can be processed by heat or pressure', and it is inexpensive and there is no limit on the size of the material. The scope of application is diverse.

On the other hand, among the above synthetic bones, calcium phosphate-based synthetic bones attracted attention as they were found to bind to hard tissues without inflammatory reactions or new fibrous tissues when applied to animal experiments.

These calcium phosphate-based synthetic bones exist in a wide variety according to the ratio of calcium and phosphorus (Ca/P).

On the other hand, each calcium phosphate-based synthetic bone has different thermodynamic properties according to the ratio of calcium and phosphorus, and shows a difference in solubility in a human body or a solution similar to that of the human body.

Therefore, when various calcium phosphate-based synthetic bones are inserted in vivo, they exhibit different biological reactions from the surrounding tissues. In particular, calcium and phosphorus dissolved in the living body greatly affect bone regeneration in vivo. It is known to give.

In other words, calcium phosphate-based synthetic bone is classified into bioinertness, bioactivity, and biodegradability according to the Ca/P ratio. More specifically, when Ca/P is 0.5, monocalcium phosphate monohydrate (Ca(H ₂ PO ₄ ) ₂ ·H ₂ O), 1.0 is dicalcium phosphate dihydrate (CaHPO ₄ ·2H ₂ O), 1.33 is octacalcium phosphate (Ca ₈ H ₂ (PO ₄ ) ₆ ·5H ₂ O), 1.3 to 1.67 is amorphous calcium phosphate (CaxHy(PO ₄ )znH ₂ O, n=3~4.5, 15-20% H ₂ O), 1.5 is α-tricalcium phosphate (α-Ca ₃ (PO ₄ ) ₂ ), 1.67 is hydroxyapatite (Ca ₁₀ (PO ₄ ) ₆ ( OH) ₂ ), and 2.0 is tetracalcium phosphate (Ca ₄ (PO ₄ ) ₂ O).

However, since the dissolution property of the calcium phosphate-based synthetic bone varies depending on the pH of the solution, there is a problem in that it is not easy to manufacture.

Furthermore, the calcium phosphate-based synthetic bone has excellent hydrophilicity and is helpful for cell adhesion or proliferation, and monovalent ions such as Na ⁺ , K ⁺ , Li ^+, etc. or Sr ²⁺ , Ba ²⁺ , Pb ²⁺ , Mn ²⁺ , Sn ²⁺ , Zn ^2+, or the like, replacement with divalent ions, Al ³⁺ ions, or defects can change the material properties.

In order to impart another property, high-temperature treatment may be performed, and during high-temperature heat treatment, some calcium phosphate-based synthetic bones cause volatilization of phosphate, resulting in a phase transition to a material with low Ca/P.

On the other hand, the octacalcium phosphate (OCP) is a calcium phosphate-based ceramic with a calcium and phosphorus ratio of 1.33, and its dissolution property is neither too fast nor too slow, so it plays a role as bone cement well until new bones grow, and after new bones grow, It partially dissolves and disappears, creating an environment in which new bones can grow well, and has good cell adhesion and non-cytotoxicity, and the results of test-tube and animal experiments are very excellent, which is attracting attention as a synthetic bone graft material.

However, since the OCP has a property of easily changing into another material by pH, it is difficult to synthesize high-purity OCP in large quantities, and thus, there is a problem that it has not been distributed in the biomaterial market yet.

The present invention was invented to solve the above-described problems, and it is an object of the present invention to provide a synthetic bone graft material manufacturing apparatus capable of mass-producing a synthetic bone graft material, in particular, a calcium phosphate-based synthetic bone graft material including OCP in a simple, rapid and high purity manner. To do.

In addition, another object is to provide a synthetic bone graft manufacturing apparatus capable of controlling the crystal phase of the synthetic bone graft material produced by precisely controlling the stirring speed, temperature and pH in the reaction process of the raw material.

On the other hand, the objects of the present invention are not limited to the above-mentioned objects, and other objects that are not mentioned will be clearly understood by those skilled in the art from the following description.

In order to achieve the above-described object, the apparatus for manufacturing a synthetic bone graft material according to an embodiment of the present invention includes a reaction chamber for reacting by introducing a raw material of the synthetic bone graft material, and a drive provided on the top of the reaction chamber and provided with a vertical rotation axis. A motor, at least one impeller connected to the rotation shaft to stir and react the raw material of the synthetic bone graft material injected into the reaction chamber, a synthetic bone graft material provided on the upper side of the reaction chamber and reacted inside the reaction chamber At least one pH meter for measuring the pH of raw materials, an acidic material injection port and an alkaline material injection port for controlling the crystal phase of the synthetic bone graft material, which is provided on the upper part of the reaction chamber and controls the pH of the synthetic bone graft material And a heating means for controlling the crystal phase of the synthetic bone graft material produced by heating the synthetic bone graft raw material injected into the reaction chamber on the outer circumferential surface of the reaction chamber.

Preferably, the reaction chamber may have an aspect ratio of 2:1 or 3:1.

Preferably, it is provided under the reaction chamber and may include a valve for discharging the synthetic bone graft material in which the reaction has been completed.

Preferably, the heating means may be any one selected from the group consisting of a hot wire heater, a hot water heater, and an oil heater.

Preferably, the impeller includes an upper impeller, an intermediate impeller, and a lower impeller, and the upper impeller, the intermediate impeller, and the lower impeller may be provided on the rotation shaft at equal intervals.

Preferably, the pitch angle of the upper impeller is formed to generate a downward vortex according to rotation, the pitch angle of the lower impeller is formed to generate a rising vortex according to rotation, and the pitch angle of the intermediate impeller is Accordingly, it may be formed to simultaneously generate an upward vortex and a downward vortex.

Preferably, the pH meter may be provided at the upper, middle and lower portions of the reaction chamber, respectively.

Preferably, a pressure measuring device for measuring the internal pressure of the reaction chamber may be provided above the reaction chamber.

Preferably, a temperature measuring device for measuring the internal temperature of the reaction chamber may be provided above the reaction chamber.

Preferably, a pressurized gas injection port is provided on the upper part of the reaction chamber, and the pressurized gas injected through the pressurized gas injection port may block evaporation of the synthetic bone graft raw material injected into the reaction chamber.

The synthetic bone graft manufacturing site according to an embodiment of the present invention can manufacture a synthetic bone graft material, in particular, a calcium phosphate-based synthetic bone graft material including OCP in a simple, rapid, and high-purity mass manner.

In addition, the synthetic bone graft manufacturing site according to an embodiment of the present invention has an excellent effect of controlling the crystal phase of the synthetic bone graft material produced by precisely controlling the stirring speed, temperature and pH in the reaction process of the raw material.

1 is a perspective view showing the overall configuration of a synthetic bone graft manufacturing site according to an embodiment of the present invention.

Figure 2 is a side view of the synthetic bone graft manufacturing plant shown in Figure 1;

The present invention relates to an apparatus for manufacturing a synthetic bone graft material, and more specifically, a reaction chamber for reacting by introducing a raw material for a synthetic bone graft material; A drive motor provided above the reaction chamber and having a vertical rotation shaft; At least one impeller connected to the rotation shaft to stir and react the raw material of the synthetic bone graft material injected into the reaction chamber; At least one pH meter provided above the reaction chamber and configured to measure the pH of the raw material of the synthetic bone graft material reacted in the reaction chamber; An acid material injection port and an alkali material injection port provided on the upper part of the reaction chamber and for controlling a crystal phase of the synthetic bone graft material produced by adjusting the pH of the synthetic bone graft material; And a heating means for controlling the crystal phase of the synthetic bone graft material produced by heating the raw material of the synthetic bone graft material injected into the reaction chamber on the outer circumferential surface of the reaction chamber.

As for terms used in the invention, general terms that are currently widely used are selected, but in certain cases, some terms are arbitrarily selected by the applicant. In this case, the meanings described or used in the detailed description of the invention are considered rather than the names of simple terms. The meaning should be grasped.

Hereinafter, the technical configuration of the present invention will be described in detail with reference to exemplary embodiments shown in the accompanying drawings.

However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. The same reference numbers throughout the specification indicate the same elements.

In this regard, first, FIG. 1 is a perspective view showing the overall configuration of a synthetic bone graft manufacturing plant according to an embodiment of the present invention, and FIG. 2 is a side view of the synthetic bone graft manufacturing plant shown in FIG. 1.

1 and 2, an apparatus 100 for manufacturing a synthetic bone graft material according to an embodiment of the present invention includes a reaction chamber 110 for reacting raw materials for a synthetic bone graft material.

At this time, the reaction chamber 110 is a space in which the raw material of the synthetic bone graft material is input and reacts, and may be formed in various shapes. In one embodiment of the present invention, the reaction chamber 110 has a cylindrical shape.

In addition, the reaction chamber 110 may be made of various materials, but in an embodiment of the present invention, the reaction chamber 110 is made of transparent glass so that the reaction process inside can be visually confirmed.

In particular, the reason for limiting the reaction chamber 110 to transparent glass in an embodiment of the present invention is as follows.

First, the raw material of the synthetic bone graft material is introduced into the reaction chamber in a liquid state. At this time, the thermal conductivity of the raw material of the synthetic bone graft material is about 0.6 W/mK and about 1.1 W/mK in the case of glass. The difference in thermal conductivity between the raw material of the synthetic bone graft material and the glass is about 0.5.

If stainless steel is used as the material of the reaction chamber 110, the thermal conductivity of stainless steel is about 12 to 45 W/m.K, and the difference from the thermal conductivity of the raw material of the synthetic bone graft material is severe, making precise temperature control difficult.

In addition, in the case of glass, the coefficient of thermal expansion is about 8.1×10 ^-5 /℃, so that the influence on the quality of the product can be minimized.

Accordingly, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention minimizes the difference in thermal conductivity between the raw material of the synthetic bone graft material and the reaction chamber 110 as described above, thereby enabling precise reaction temperature control and thermal expansion. Glass is used to minimize the deterioration of product quality due to counting.

Meanwhile, the reaction chamber 110 of the apparatus 100 for manufacturing a synthetic bone graft material according to an embodiment of the present invention has an aspect ratio, that is, a vertical to horizontal ratio of 2:1 or 3:1.

The reason for limiting the aspect ratio of the reaction chamber 110 to 2:1 or 3:1 is as follows.

First, a synthetic bone graft raw material is injected into the reaction chamber 110, and the injected synthetic bone graft raw material is heated by a heating means 150 to be described later.

In this case, the raw material of the synthetic bone graft material is evaporated by heating the heating means 150 and the evaporation amount is proportional to the horizontal cross-sectional area of the reaction chamber 110.

On the other hand, the evaporation of the raw material of the synthetic bone graft material causes a difference in concentration between the surface where evaporation occurs and the lower portion where evaporation does not occur. It becomes difficult.

Accordingly, the reaction chamber 110 according to an embodiment of the present invention limited the aspect ratio of the reaction chamber 110 to 2:1 or 3:1 in order to minimize the evaporation amount of the raw material for the synthetic bone graft material.

Meanwhile, the synthetic bone graft raw material may be introduced into the reaction chamber 110 by opening and closing the upper portion of the reaction chamber 110. As shown in FIG. It may be inserted by providing an inlet 115 for inputting raw materials of the synthetic bone graft material at the top.

Meanwhile, the apparatus 100 for manufacturing a synthetic bone graft material according to an embodiment of the present invention includes a driving motor 120 provided on the reaction chamber 110 and having a vertical rotation shaft 121.

At this time, the driving motor 120 is a configuration for rotating the impeller (122) (122a) (122b) (122c) for the stirring reaction of the raw material of the synthetic bone graft material, and various types of driving motors may be used. , In one embodiment of the present invention, the drive motor uses a step motor that facilitates precise control of RPM.

On the other hand, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention is at least for reacting by stirring the raw material of the synthetic bone graft material that is connected to the rotation shaft 121 and introduced into the reaction chamber 110. It includes one or more impellers 122.

At this time, the impeller 122 may be provided in an appropriate number as needed, but in an embodiment of the present invention, as shown in FIG. 2, an upper impeller 122a, an intermediate impeller 122b, and a lower impeller ( 122c) consists of a total of three, and the three

impellers

122a, 122b, and 122c are provided on the same rotation shaft 121 at equal intervals.

Meanwhile, in an embodiment of the present invention, the impeller 122 has the following structural features, and will be described in detail below.

In this regard, first referring to FIG. 2, the three

impellers

122a, 122b, and 122c each have two rotating blades, and at this time, the pitch angle of the upper impeller 122a generates a downward vortex according to rotation. The pitch angle of the lower impeller 122c is formed to generate a rising vortex according to rotation, and the pitch angle of the intermediate impeller 122b is formed to simultaneously generate a rising vortex and a falling vortex according to rotation. Thus, the raw material of the synthetic bone graft material is flowed as shown in FIG. 2.

On the other hand, the stirring speed of the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention is characterized in that the stirring is 1 ~ 300RPM, more preferably 30 ~ 60RPM.

The reason for stirring at low RPM is that in the case of high-speed stirring, since it is pushed by centrifugal force rather than stirring reaction, there is a problem in that an efficient stirring reaction does not occur.

Accordingly, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention can maximize the reaction efficiency of the synthetic bone graft raw material by stirring the raw material at a low RPM.

In addition, the impeller 122 and the rotation shaft 121 may be made of various materials, but in an embodiment of the present invention, it is made of Teflon to improve corrosion resistance.

As a result, it is possible to improve the homogeneous reaction and reaction speed of the raw materials of the synthetic bone graft material according to the flow of the raw materials of the synthetic bone graft material as described above, and through this, it is possible to quickly and in large quantities produce a synthetic bone graft material of uniform quality. have.

On the other hand, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention is provided above the reaction chamber 110 and measures the pH of the synthetic bone graft raw material reacted inside the reaction chamber 110 At least one pH meter 130 is provided for this.

In general, since a synthetic bone graft material has different dissolution properties and crystal phases depending on the pH in the manufacturing process, precise pH control is essential in the manufacturing process in order to manufacture a synthetic bone graft material having desired properties.

At this time, for precise pH control, accurate pH measurement in the reaction process is a prerequisite. For this purpose, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention includes the pH meter 130 at the inner upper part of the reaction chamber. It is provided in (130a), the middle part (130b), and the lower part (130c), respectively.

As a result, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention has three pH meters 130 (130a) (130b) (130c) as described above, and the pH value is calculated as an average value thereof. By calculating, it is possible to precisely control the pH in the manufacturing process of the synthetic bone graft material.

On the other hand, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention is provided above the reaction chamber 110 and controls the crystal phase of the synthetic bone graft material manufactured by adjusting the pH of the raw material of the synthetic bone graft material. It includes an acidic material injection port 111 and an alkaline material injection port 112 for.

The raw material of the synthetic bone graft material changes its pH depending on the reaction temperature or time during the reaction process, and it is necessary to continuously maintain and control the selected pH in order to manufacture the synthetic bone graft material having a specific crystal phase.

Accordingly, in an embodiment of the present invention, as described above, an acidic substance injection hole 111 and an alkaline substance injection hole 112 are provided at the upper portion of the reaction chamber 110, and the pH measured through the pH meter 130 is used. An acidic substance or an alkaline substance is injected to maintain the selected pH or control the crystal phase.

As an example of this, in the manufacture of octacalcium phosphate (OCP), it is necessary to maintain a pH of 5 to 6, but when the pH value through the pH meter 130 is out of the range, the range is adjusted through the

inlet

111 and 112. Acid or alkaline substances are injected to maintain.

On the other hand, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention is provided under the reaction chamber 110 and includes a valve 140 for discharging the reaction-completed synthetic bone graft material. .

When the reaction to the synthetic bone graft material is completed, the synthetic bone graft raw material is deposited in the lower part of the reaction chamber 110 in the form of a precipitate.

Accordingly, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention has the valve 140 in order to simply obtain the synthetic bone graft material deposited in the lower portion of the reaction chamber 110, and the valve ( The synthetic bone graft material manufactured by opening 140) is discharged to the outside of the reaction chamber 110.

Synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention not only can simply obtain the synthetic bone graft material deposited in the lower portion through the above-described valve 140, the manufactured synthetic bone graft material is discharged There is also an effect that the raw material of the synthetic bone graft material remaining in the reaction chamber 110 can be reused.

On the other hand, since the valve 140 may use all of the valves in various ways, there is no particular limitation on this.

On the other hand, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention, as shown in FIG. 1, the synthetic bone graft raw material injected into the reaction chamber 110 on the outer circumferential surface of the reaction chamber 110. It includes a heating means 150 for controlling the crystal phase of the synthetic bone graft material produced by heating.

At this time, the outer circumferential surface means the side and lower surfaces of the reaction chamber 110 in a cylindrical shape, through which the raw material of the synthetic bone graft material is uniformly heated.

On the other hand, in one embodiment of the present invention, the heating means 150 may be provided as a hot wire heater, and in another embodiment, a hot water heater using hot water supplied through a pipe surrounding the outer circumferential surface or an oil heater using heated oil. It can also be made of.

On the other hand, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention is a pressure measuring device 160 and the reaction chamber for measuring the internal pressure of the reaction chamber 110 on the upper portion of the reaction chamber 110. A temperature measuring device 170 for measuring the internal temperature of 110 is provided.

The reaction conditions of the raw material of the synthetic bone graft material may be monitored and controlled through the pressure measuring device 160 and the temperature measuring device 170.

In addition, the synthetic bone graft manufacturing apparatus 100 according to an embodiment of the present invention is provided with a pressurized gas injection port 113 on the upper part of the reaction chamber 110, and pressurized injected through the pressurized gas injection port 113 The gas is filled in the upper empty space of the reaction chamber 110 into which the raw material of the synthetic bone graft material is injected and serves to block the evaporation of the raw material of the synthetic bone graft material.

At this time, the pressurized gas is an inert gas such as argon (Ar), neon (Ne), helium (He), nitrogen (N) and carbon dioxide (CO ₂ ), and the reaction chamber 110 using the pressurized gas It is preferable that the internal pressure is 0.2 to 0.6 MPa.

On the other hand, the pressurized gas may be discharged through the pressurized gas inlet 113 after the synthetic bone graft reaction is completed, but in another embodiment, a separate pressurized gas outlet 114 at the upper portion of the reaction chamber 110 It may be discharged through it by having.

As a result, the synthetic bone graft manufacturing apparatus 100 according to the embodiments of the present invention can produce a synthetic bone graft material, in particular, a calcium phosphate-based synthetic bone graft material including OCP in a simple, fast and high-purity mass manner through the above-described technical configurations. In addition, the synthetic bone graft manufacturing plant according to an embodiment of the present invention has an excellent effect of controlling the crystal phase of the synthetic bone graft material produced by precisely controlling the stirring speed, temperature and pH in the reaction process of the raw material.

As described above, the present invention has been illustrated and described with a preferred embodiment, but is not limited to the above-described embodiment, and within the scope of the spirit of the present invention, those of ordinary skill in the art Various changes and modifications will be possible.

The present invention relates to an apparatus for manufacturing a synthetic bone graft material, and more specifically, a calcium phosphate-based synthesis that has different thermodynamic properties depending on the ratio of calcium and phosphorus (Ca/P), and shows a difference in solubility in a human body or a solution similar to that of the human body. The bone graft material can be manufactured in large quantities with simple, rapid and high purity, and thus has industrial applicability.

Claims

A reaction chamber for reacting raw materials of the synthetic bone graft material;

A drive motor provided above the reaction chamber and provided with a vertical rotation shaft;

At least one impeller connected to the rotation shaft to stir and react the raw material of the synthetic bone graft material injected into the reaction chamber;

At least one pH meter provided above the reaction chamber and configured to measure the pH of the raw material of the synthetic bone graft material reacted in the reaction chamber;

An acid material injection port and an alkali material injection port provided on the upper part of the reaction chamber and for controlling a crystal phase of the synthetic bone graft material produced by adjusting the pH of the synthetic bone graft material; And

And a heating means for controlling the crystal phase of the synthetic bone graft material produced by heating the raw material of the synthetic bone graft material injected into the reaction chamber on the outer circumferential surface of the reaction chamber.
The method of claim 1,

The reaction chamber is a synthetic bone graft manufacturing apparatus, characterized in that the aspect ratio of 2:1 or 3:1.
The method of claim 1,

A synthetic bone graft manufacturing apparatus comprising a valve provided under the reaction chamber and for discharging the synthetic bone graft material in which the reaction has been completed.
The method of claim 1,

The heating means is a synthetic bone graft manufacturing apparatus, characterized in that any one selected from the group consisting of a heated heater, a hot water heater and an oil heater.
The method of claim 1,

The impeller is composed of an upper impeller, an intermediate impeller and a lower impeller, and the upper impeller, the intermediate impeller and the lower impeller are provided on the rotation shaft at equal intervals.
The method of claim 5,

The pitch angle of the upper impeller is formed to generate a falling vortex according to rotation, the pitch angle of the lower impeller is formed to generate a rising vortex according to rotation, and the pitch angle of the intermediate impeller is formed to generate a rising vortex according to rotation. Synthetic bone graft manufacturing apparatus, characterized in that formed to simultaneously generate and descending vortex.
The method of claim 1,

The pH meter is a synthetic bone graft manufacturing apparatus, characterized in that provided in each of the inner upper, middle and lower portions of the reaction chamber.
The method of claim 1,

Synthetic bone graft manufacturing apparatus, characterized in that provided with a pressure gauge for measuring the internal pressure of the reaction chamber above the reaction chamber.
The method of claim 1,

A synthetic bone graft manufacturing apparatus, characterized in that a temperature measuring device for measuring the internal temperature of the reaction chamber is provided at an upper portion of the reaction chamber.
The method of claim 1,

An apparatus for manufacturing a synthetic bone graft material, characterized in that a pressurized gas injection port is provided at an upper portion of the reaction chamber, and the pressurized gas injected through the pressurized gas injection port blocks evaporation of the raw material of the synthetic bone graft material injected into the reaction chamber.