WO2020239627A1 - Composition de soin buccal - Google Patents

Composition de soin buccal Download PDF

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Publication number
WO2020239627A1
WO2020239627A1 PCT/EP2020/064284 EP2020064284W WO2020239627A1 WO 2020239627 A1 WO2020239627 A1 WO 2020239627A1 EP 2020064284 W EP2020064284 W EP 2020064284W WO 2020239627 A1 WO2020239627 A1 WO 2020239627A1
Authority
WO
WIPO (PCT)
Prior art keywords
oral care
care composition
silica
enzyme
composition according
Prior art date
Application number
PCT/EP2020/064284
Other languages
English (en)
Inventor
Haidee Rachel BOOTH
Richard Aaron FORREST
Robert Edward Marriott
Robert George Riley
Original Assignee
Unilever Plc
Unilever N.V.
Conopco, Inc., D/B/A Unilever
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc, Unilever N.V., Conopco, Inc., D/B/A Unilever filed Critical Unilever Plc
Priority to BR112021021541A priority Critical patent/BR112021021541A2/pt
Priority to CN202080039349.XA priority patent/CN114585418A/zh
Priority to EP20726479.7A priority patent/EP3976203A1/fr
Publication of WO2020239627A1 publication Critical patent/WO2020239627A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

Definitions

  • the present invention is concerned with compositions comprising enzymes. More particularly, the present invention is concerned with oral care compositions containing enzymes.
  • compositions containing enzymes are described in EP3192496, EP3192495 and EP3192565 and EP3192564. However there remains the need to formulate compositions with enhanced enzyme activity.
  • the present application relates to a composition and method, for enhancing the activity of enzymes in oral care products.
  • the present application relates to a composition
  • a composition comprising a surfactant, an enzyme and silica, in which at least 50wt % of at least one enzyme is adsorbed to a silica.
  • the application further relates to a process for preparing a composition according to any preceding claim in which the enzyme is added to a pre-mix of silica.
  • Adsorption is a surface phenomenon in which particles or molecules bind to the top layer of material.
  • any feature of one aspect of the present invention may be utilised in any other aspect of the invention.
  • Any feature described as‘preferred’ should be understood to be particularly preferred in combination with a further preferred feature or features.
  • any feature of a particular embodiment may be utilized in any other embodiment of the invention. All percentages are weight/weight percentages unless otherwise indicated.
  • compositions comprising enzymes, preferably the compositions are personal care compositions and more preferably the compositions are oral care compositions.
  • Preferred product forms for compositions of the invention are those which are suitable for brushing and/or rinsing the surfaces of the oral cavity.
  • the composition of the invention is most preferably in the form of a dentifrice.
  • dentifrice denotes an oral composition which is used to clean the surfaces of the oral cavity. Such a composition is not intentionally swallowed for purposes of systemic administration of therapeutic agents, but is applied to the oral cavity, used to treat the oral cavity and then expectorated. Typically such a composition is used in conjunction with a cleaning implement such as a toothbrush, usually by applying it to the bristles of the toothbrush and then brushing the accessible surfaces of the oral cavity.
  • the dentifrice/toothpaste is in the form of an extrudable semi-solid such as a cream, paste or gel (or mixture thereof).
  • compositions according to the invention comprise enzymes.
  • the enzymes are selected from the following groups:
  • glycoside hydrolase more preferably an amylase, most preferably amylglucosidase
  • an oxoreductase acting on OH groups of donors more preferably an oxidase with oxygen as acceptor, most preferably glucose oxidase;
  • hemeperoxidase more preferably a haloperoxidase most preferably a lactoperoxidase.
  • the enzyme is a mixture of 2 of the above, more preferably 3 of the above, most preferably a mixture of amylglucosidase, glucose oxidase and lactoperoxidase.
  • glucose oxidase either alone or part of the enzyme mix is particularly preferred.
  • the total level of enzyme is from 0.01 wt% to 2wt% of the total composition. More preferably from 0.05 wt% to 1 wt% of the total composition.
  • the total level of glycoside hydrolase in the composition is from 0.05 to 1 wt% of the total composition.
  • the total level of oxoreductase acting on OH groups of donors is from 0.05 to 1 wt% of the total composition.
  • the total level of hemeperoxidase is from 0.0005 to 0.01 wt% of the total composition.
  • the weight ratio of glycoside hydrolase to other enzymes in the composition is greater than 1 :1 , more preferably greater than 3:2.
  • compositions of the invention may also comprise other proteins such as lysozymes, lactoferrins and colostrum.
  • these other proteins are present at total levels from 0.001 to 0.5 wt% of the total composition, preferably from 0.005 to 0.1 wt% of the total composition.
  • Composition according to the invention comprise a silica.
  • the preferred silica used in the present invention is a silica with a low refractive index. It may be used as the sole abrasive silica, or in conjunction with a low level of other abrasive silicas, e.g. those according to EP 236070.
  • the low refractive index silicas, used as abrasives in the present invention are preferably silicas with an apparent refractive index (R.l.) in the range ffornl .41 to1.47, more preferably from 1.43 to1.45, preferably having a weight mean particle size of from 5 to 15 pm, a BET (nitrogen) surface area of from 10 to 150 m 2 /g, more preferably and an oil absorption of about 70 - 150 cm 3 /100 g, but abrasive silicas with a lower apparent refractive index may also be used.
  • suitable low refractive index abrasive silicas e.g. having an R.l.
  • silicas of between 1.435 and 1.445 are Tixosil 63 and 73 ex Rhone Poulenc; Sident 10 ex Degussa; Zeodent 113 ex Zeofinn; Zeodent 124 ex Huber, Sorbosil AC 77 ex Crosfield Chemicals (having an R.l. of approximately 1.440).
  • the amount of these silicas in the composition generally ranges from 5 to 60% by weight of the total composition more preferably from 5 to 20% by weight.
  • the enzyme is adsorbed onto a thickening silica.
  • the silica is has an oil absorbing level of less than 150 cm 3 /100g, more preferably less than 1 cm 3 /100g.
  • the silica is a milled silica.
  • the silica has a average particle size from 8 to 14 microns .more preferably from 10 to 12 microns.
  • Particularly preferred silicas are Zeodent 165 and Tixosil 43 as silicas of this type are preferred as they enhance enzyme activity.
  • the ratio of total silica to total enzyme is from 150: 1 to 5: 1 more preferably from 100: 1 to 10:1 , most preferably from 60: 1 to 20: 1.
  • the enzyme is preferably adsorbed onto the silica.
  • the adsorption can occur either by a main batch method in which enzyme(s) are added immediately after silica dispersion and before polymer thickener / structurants and / or flavour or by using a side pot in which silica is added to an enzyme premix solution, the premix is then added to the main batch before polymer thickener/ structurants and / or flavour.
  • the oral care composition will preferably contain a surfactant in an amount from 0.2 to 7% by weight of the composition.
  • a surfactant such as polyethoxylated fatty acid sorbitan esters, ethoxylated fatty acids, esters of polyethylene glycol, ethoxylates of fatty acid
  • polyethylene glycol ethers of fatty alcohols in particular polyethylene glycol ethers having from 20 to 40 ethylene oxide groups per unit.
  • suitable surfactant include the group of surfactants known as Steareth surfactants such as Steareth 30.
  • the level of non-ionic surfactant is from 0.5 to 7 wt% of the total composition, more preferably from 1 to 5 wt% of the total composition.
  • surfactants may be present it is preferred if they are limited to levels below 0.5 wt% of the total composition preferably less than 0.1 wt% of the total composition.
  • the oral care composition may also contain structurants and agents such as binders and thickening agents.
  • structurants will generally be present in an amount of from 0.1 to 1 % by weight based on the total weight of the composition.
  • Suitable binders or thickening agents include carboxyvinyl polymers (such as polyacrylic acids cross-linked with polyallyl sucrose or polyallyl pentaerythritol), hydroxyethyl cellulose, hydroxypropyl cellulose, natural gums (such as carrageenan, gum karaya, guar gum, xanthan gum, gum arabic, and gum tragacanth). Natural gum based thickeners, in particular carrageenan are particularly preferred.
  • the amount of water and/or polyhydric alcohol will generally be at least 10 percent, preferably at least 30 percent, more preferably at least 50 percent by total weight water and/or polyhydric alcohol based on the total weight of the composition.
  • the level of water and/or polyhydric alcohol will be less than 90 wt% of the total composition, more preferably less than 85 wt%.
  • a dentifrice composition according to the invention will usually contain, as the aqueous continuous phase, a mixture of water and polyhydric alcohol in various relative amounts, with the amount of water generally ranging from 10 to 50% by weight (based on the total weight of the dentifrice) and the amount of polyhydric alcohol generally ranging from 20 to 60% by weight (based on the total weight of the dentifrice).
  • Typical polyhydric alcohols for use in the oral care composition, particularly a dentifrice composition according to the invention include humectants such as glycerol, sorbitol, polyethylene glycol, polypropylene glycol, propylene glycol, xylitol (and other edible polyhydric alcohols), hydrogenated partially hydrolysed polysaccharides and mixtures thereof. Glycerol and sorbitol are preferred, sorbitol being particularly preferred.
  • the oral care composition in particular dentifrice compositions comprises abrasive materials.
  • Abrasive materials will generally be present in an amount of from 0.5 to 75%, preferably 3 to 60% by weight based on the total weight of the dentifrice.
  • Suitable abrasive cleaning agents include silica xerogels, hydrogels and aerogels and precipitated particulate silicas; calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcined alumina, sodium and potassium
  • the composition particularly a toothpaste, comprises a silica based abrasive as described above.
  • composition particularly if a toothpaste preferably comprises an inorganic or a natural or synthetic thickener or gelling agent in proportions of about 0.10 to about 15% by weight of the total composition, depending on the material chosen.
  • thickeners in the dentifrice compositions of the present invention form an extrudable, shape-retaining product which can be squeezed from a tube onto a toothbrush and will not fall between the bristles of the brush but rather, will substantially maintain its shape thereon.
  • Suitable thickeners or gelling agents useful in the practice of the present invention include finely divided silicas, hectorites, calcium carbonate, colloidal magnesium aluminium silicates and mixtures thereof.
  • inorganic thickening silicas such as amorphous silicas available from Huber Corporation under the trade designation Zeodent 165, and/or gums such as Irish moss, iota-carrageenan, gum tragacanth, and polyvinylpyrrolidone.
  • compositions of the invention may comprise a metal ion such as tin or zinc.
  • a metal ion such as tin or zinc.
  • the sources of zinc ions are zinc chloride, zinc acetate, zinc gluconate, zinc sulphate, zinc fluoride, zinc citrate, zinc lactate, zinc oxide, zinc monoglycerolate, zinc tartrate, zinc pyrophosphate zinc maleate and mixtures thereof.
  • compositions of the invention may comprise fluoride sources such as sodium fluoride, stannous fluoride, sodium monofluorophosphate, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride, cobalt ammonium fluoride and mixtures thereof.
  • fluoride sources such as sodium fluoride, stannous fluoride, sodium monofluorophosphate, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride, cobalt ammonium fluoride and mixtures thereof.
  • Compositions of the present invention may also contain further optional ingredients customary in the art such as antimicrobial agents, e.g.
  • anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.;
  • anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium
  • plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium
  • vitamins such as Vitamins A, C and E;
  • plant-derivable antioxidants such as flavonoid, catechin, polyphenol, and tannin compounds and mixtures thereof;
  • desensitising agents e.g. potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts;
  • anti-calculus agents e.g. alkali-metal pyrophosphates, hypophosphite-containing polymers, organic phosphonates and phosphocitrates etc.;
  • biomolecules e.g. bacteriocins, antibodies, enzymes, etc.
  • flavours e.g. peppermint and spearmint oils
  • proteinaceous materials such as collagen
  • amino acids such as arginine
  • pharmaceutically acceptable carriers e.g. starch, sucrose, water or water/alcohol systems etc.
  • surfactants such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants
  • humectants such as glycerol, sorbitol, propyleneglycol, xylitol, lactitol etc.;
  • binders and thickeners such as Niatrosol®), xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol®;
  • polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included;
  • buffers and salts to buffer the pH and ionic strength of the oral care composition are e.g. bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate
  • effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • composition of the glucose oxidase premix is as in Table 1 :
  • the samples were prepared following the amounts in Table 2. Powders were dispersed using a magnetic stirrer for 30 minutes at room temperature. Zeta potential was measured using dynamic light scattering using a Malvern ZetaSizer NanoSeries with a universal dip cell and a backscatter angle of 173 degrees. After diluting the samples using water to minimise turbidity. All measurements were repeated three times. The zeta potential results demonstrate a significant adsorption of enzyme, Glucose oxidase (GOx) onto silicas indicated by the large drop in surface charge of the particles.
  • GOx Glucose oxidase
  • Glucose Oxidase was incubated at 37°C with individual formula ingredients in 0.05 mM citrate- phosphate buffer, pH 7. After 10 mins Glucose oxidase activity was measured using Standard Kits and Reagents
  • Table 3 demonstrates when enzyme is adsorbed onto silica the activity increases. Zeodent 113 gives enhanced enzyme activity compared with Tixosil 43
  • An Example according to the invention is as follows:
  • composition contains 1450ppm F as NaF * Precipitated silica
  • glucose oxidase is added to the thickening silica prior to addition to the toothpaste mix.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Une composition comprenant une enzyme et de la silice, dans laquelle au moins 50% en poids d'au moins une enzyme est adsorbée sur une silice.
PCT/EP2020/064284 2019-05-28 2020-05-22 Composition de soin buccal WO2020239627A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
BR112021021541A BR112021021541A2 (pt) 2019-05-28 2020-05-22 Composição de dentifrício, composição de cuidados orais e processo de preparação de composições
CN202080039349.XA CN114585418A (zh) 2019-05-28 2020-05-22 口腔护理组合物
EP20726479.7A EP3976203A1 (fr) 2019-05-28 2020-05-22 Composition de soin buccal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19176970 2019-05-28
EP19176970.2 2019-05-28

Publications (1)

Publication Number Publication Date
WO2020239627A1 true WO2020239627A1 (fr) 2020-12-03

Family

ID=66668813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2020/064284 WO2020239627A1 (fr) 2019-05-28 2020-05-22 Composition de soin buccal

Country Status (4)

Country Link
EP (1) EP3976203A1 (fr)
CN (1) CN114585418A (fr)
BR (1) BR112021021541A2 (fr)
WO (1) WO2020239627A1 (fr)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236070A2 (fr) 1986-02-28 1987-09-09 Unilever Plc Silices
FR2732593A1 (fr) * 1995-04-04 1996-10-11 Bieurope Compositions cosmetiques a base d'enzymes proteases ou beta-glucosidases immobilisees pour favoriser l'elimination des cellules superficielles de la peau
WO1997023241A1 (fr) * 1995-12-21 1997-07-03 Quest International B.V. Compositions de particules
WO2014067933A1 (fr) * 2012-10-31 2014-05-08 C-Lecta Gmbh Préparation de support bioactif pour une sécurité améliorée dans les produits de soin et les aliments
US9540631B1 (en) * 2004-09-14 2017-01-10 Peter T. Pugliese Immobilized glucose oxidase for use in oral hygiene
EP3192564A1 (fr) 2016-01-12 2017-07-19 Unilever PLC Composition de protection orale
EP3192565A1 (fr) 2016-01-12 2017-07-19 Unilever PLC Composition de protection orale contenant un proteine pour balancer la flore bactérielle de la bouche
EP3192496A1 (fr) 2016-01-12 2017-07-19 Unilever PLC Compositions de protection orale
EP3192495A1 (fr) 2016-01-12 2017-07-19 Unilever PLC Compositions de protection orale

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE223223T1 (de) * 1997-06-17 2002-09-15 Novozymes As Zusammensetzung zur mundhygiene, die eine bakterielle pullulanase und dextranase enthält
US6379654B1 (en) * 2000-10-27 2002-04-30 Colgate Palmolive Company Oral composition providing enhanced tooth stain removal
PL205718B1 (pl) * 2001-06-25 2010-05-31 Procter & Gamble Kompozycja ścierająca do czyszczenia zębów i zastosowanie kompozycji ścierającej do czyszczenia zębów
CN102015028A (zh) * 2008-04-22 2011-04-13 丹尼斯科美国公司 含有氧化酶的口腔护理组合物

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236070A2 (fr) 1986-02-28 1987-09-09 Unilever Plc Silices
FR2732593A1 (fr) * 1995-04-04 1996-10-11 Bieurope Compositions cosmetiques a base d'enzymes proteases ou beta-glucosidases immobilisees pour favoriser l'elimination des cellules superficielles de la peau
WO1997023241A1 (fr) * 1995-12-21 1997-07-03 Quest International B.V. Compositions de particules
US9540631B1 (en) * 2004-09-14 2017-01-10 Peter T. Pugliese Immobilized glucose oxidase for use in oral hygiene
WO2014067933A1 (fr) * 2012-10-31 2014-05-08 C-Lecta Gmbh Préparation de support bioactif pour une sécurité améliorée dans les produits de soin et les aliments
EP3192564A1 (fr) 2016-01-12 2017-07-19 Unilever PLC Composition de protection orale
EP3192565A1 (fr) 2016-01-12 2017-07-19 Unilever PLC Composition de protection orale contenant un proteine pour balancer la flore bactérielle de la bouche
EP3192496A1 (fr) 2016-01-12 2017-07-19 Unilever PLC Compositions de protection orale
EP3192495A1 (fr) 2016-01-12 2017-07-19 Unilever PLC Compositions de protection orale

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE GNPD [online] MINTEL; 22 June 2015 (2015-06-22), ANONYMOUS: "Homeopathic Toothpaste", XP055640121, retrieved from www.gnpd.com Database accession no. 3239219 *

Also Published As

Publication number Publication date
CN114585418A (zh) 2022-06-03
EP3976203A1 (fr) 2022-04-06
BR112021021541A2 (pt) 2021-12-28

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