WO2023247290A1 - Composition de soin buccodentaire pour atténuer et/ou inverser l'érosion de l'émail dentaire provoquée par l'usure d'un aligneur - Google Patents

Composition de soin buccodentaire pour atténuer et/ou inverser l'érosion de l'émail dentaire provoquée par l'usure d'un aligneur Download PDF

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Publication number
WO2023247290A1
WO2023247290A1 PCT/EP2023/065987 EP2023065987W WO2023247290A1 WO 2023247290 A1 WO2023247290 A1 WO 2023247290A1 EP 2023065987 W EP2023065987 W EP 2023065987W WO 2023247290 A1 WO2023247290 A1 WO 2023247290A1
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WO
WIPO (PCT)
Prior art keywords
composition
oral care
phosphate
sodium
aligner
Prior art date
Application number
PCT/EP2023/065987
Other languages
English (en)
Inventor
Pau BARTOLI GABAS
Alison Katharine Green
Gareth Jon OWENS
Nuria Lopez ROJANO
Original Assignee
Unilever Ip Holdings B.V.
Unilever Global Ip Limited
Conopco, Inc., D/B/A Unilever
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Ip Holdings B.V., Unilever Global Ip Limited, Conopco, Inc., D/B/A Unilever filed Critical Unilever Ip Holdings B.V.
Publication of WO2023247290A1 publication Critical patent/WO2023247290A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to oral care compositions such as toothpastes, powders, gums, serums, films, mouthwashes and the like.
  • oral care compositions such as toothpastes, powders, gums, serums, films, mouthwashes and the like.
  • the present invention relates to an oral care compositions, particularly toothpastes and serums that are effective in mitigating the negative effects of wearing a retainer on the enamel.
  • Tooth aligners in particular clear aligners have become increasingly popular with consumers over recent years.
  • aligner treatment may put consumers at higher risk of enamel demineralisation as the aligner inhibits natural remineralisation by saliva creating a minienvironment around the teeth conducive to demineralization.
  • the present invention relates to an oral care composition
  • an oral care composition comprising: a) calcium silicate and; b) sodium phosphate salt. for use in a method to mitigate erosion of tooth enamel by use of a retainer/aligner
  • kit comprising a retainer for straightening the teeth and an oral care composition comprising: a) calcium silicate and b) sodium phosphate salt.
  • composition of the invention are toothpastes, films, powders, gums, serums and mouthwashes. Serums and toothpastes are particularly preferred.
  • the composition of the invention is most preferably in the form of a dentifrice.
  • dentifrice denotes an oral composition which is used to clean the surfaces of the oral cavity. Such a composition is not intentionally swallowed for purposes of systemic administration of therapeutic agents, but is applied to the oral cavity, used to treat the oral cavity and then expectorated. Typically such a composition is used in conjunction with a cleaning implement such as a toothbrush, usually by applying it to the bristles of the toothbrush and then brushing the accessible surfaces of the oral cavity.
  • the dentifrice/toothpaste is in the form of an extrudable semi-solid such as a cream, paste or gel (or mixture thereof). Toothpastes are particularly preferred.
  • composition can be by the brushing the teeth with the product, preferably without rinsing or by applying the product with an applicator.
  • the composition of the invention may be applied to the teeth prior to placement of the aligner or after removal of the aligner
  • compositions according to the invention preferably comprise mono calcium phosphate.
  • the monocalcium phosphate is present at levels from 0.1 to 10 wt% of the total composition, more preferably 1 to 6 wt%.
  • the compositions of the invention comprise from 20 to 90 wt% of the total composition of one or more organic polyols having 3 or more hydroxyl groups in the molecule.
  • the organic polyol is glycerol.
  • compositions of the invention include agents for the remineralisation of teeth.
  • remineralisation in the context of the present invention means the in-situ generation of hydroxyapatite on teeth.
  • compositions according to the invention comprise a suitable agent for the remineralisation of teeth this a mixture of a calcium silicate and a sodium phosphate salt which, when delivered to the teeth results in the in situ generation of hydroxyapatite on teeth.
  • the amount of remineralising calcium source(s) (e.g. calcium silicate) in the composition of the invention typically ranges from 1 to 30%, preferably from 5 to 20% by total weight remineralising calcium source based on the total weight of the oral care composition.
  • remineralising phosphate sources include, for example, monosodium dihydrogen phosphate, disodium hydrogen phosphate, sodium pyrophosphate, tetrasodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, potassium dihydrogenphosphate, trisodium phosphate, tripotassium phosphate and mixtures thereof.
  • the remineralising phosphate source is a mixture of trisodium phosphate and sodium dihydrogen phosphate.
  • the amount of remineralising phosphate source(s) (e.g. trisodium phosphate and sodium dihydrogen phosphate) in the composition of this invention typically ranges from 2 to 15%, preferably from 4 to 10% by total weight re-mineralising phosphate source based on the total weight of the oral care composition.
  • the level of sodium phosphate salt is from 1 to 20wt%, preferably 2 to 15 wt% of the total composition.
  • compositions according to the invention preferably further comprise xanthan gum and/or carrageenan which can be present as structurants. It is particularly preferred that carrageenan is either iota or kappa carrageenan, a mixture of the two being particularly preferred.
  • the level of xanthan gum is from 0.1 to 0.9wt% of the total composition.
  • the level of carrageenan is from is from 0.1 to 0.9wt% of the total composition.
  • the weight ratio of xanthan gum to carrageenan is from 1 :2 to 2: 1.
  • An alternative/additional structurant can include one or more solid polyethylene glycols having a melting point of 25°C or above. Preferably the melting point ranges from 35 to 65°C, more preferably from 55 to 60° C.
  • Polyethylene glycols have the general formula H(OCH2CH2) n OH, where n is the number of repeating oxyethylene units.
  • polyethylene glycols are usually not uniform chemical compounds, but instead consist of a distribution of similar polymer members of the homologous polyethylene glycol series, defined by average values of n and molecular weight.
  • the melting point generally increases with increasing average values of n and molecular weight.
  • Suitable solid polyethylene glycols have an average value of n in the above general formula ranging from about 20 to 220, preferably from about 40 to 150, more preferably from about 32 to 90, most preferably from about 60 to 75.
  • the average molecular weight suitably ranges from about 950 to 11 ,250, preferably from about 1800 to 6600, more preferably from about 1400 to 4400, most preferably from about 2700 to 3700 g/mol.
  • Suitable commercially available materials include for example Polyglykol® 3000 (ex Clariant). Mixtures of any of the above described materials may also be used.
  • the amount of solid polyethylene glycol (as defined above) if present in compositions of the invention suitably ranges from 0.1 to 5%, preferably from 0.5 to 3%, more preferably from 1 to 2.5% by total weight solid polyethylene glycol (as defined above) based on the total weight of the composition.
  • the composition comprises from 0.2 to 5wt% of the total composition of one or more surfactants, such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants.
  • a preferred surfactant is a taurate, in particular sodium methyl cocoyl taurate. Alternatively sodium lauryl sulphate may be used.
  • a composition according to the invention (such as a dentifrice/toothpaste) will generally contain further ingredients to enhance performance and/or consumer acceptability, in addition to the ingredients specified above.
  • compositions according to the invention preferably comprise particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
  • abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
  • the composition, particularly a toothpaste comprises a silica based abrasive.
  • the preferred abrasive silicas used in the present invention is a silica with
  • the low refractive index silicas, used as abrasives in the present invention are preferably silicas with an apparent refractive index (R.l.) in the range of 1.41 - 1.47, preferably 1.435 - 1.445, preferably having a weight mean particle size of between 5 and 15 mm, a BET (nitrogen) surface area of between 10 and 100 m 2 /g and an oil absorption of about 70 - 150 cm 3 /100 g, but abrasive silicas with a lower apparent refractive index may also be used.
  • R.l. apparent refractive index
  • BET nitrogen
  • Suitable low refractive index abrasive silicas are Tixosil 63 and 73 ex Rhone Poulenc; Sident 10 ex Degussa; Zeodent 113 ex Zeofinn; Zeodent 124 ex Evonik, Sorbosil AC 77 ex PQ Corporation (having an R.l. of approximately 1.440).
  • the amount of these silicas in the composition generally ranges from 5-60% by weight, usually 5-20% by weight.
  • composition particularly if a toothpaste preferably comprises an inorganic or a natural or synthetic thickener or gelling agent in proportions of about 0.10 to about 15% by weight depending on the material chosen.
  • thickeners in the dentifrice compositions of the present invention form an extrudable, shape-retaining product which can be squeezed from a tube onto a toothbrush and will not fall between the bristles of the brush but rather, will substantially maintain its shape thereon.
  • Suitable thickeners or gelling agents useful in the practice of the present invention include inorganic thickening silicas such as amorphous silicas available from Evonik under the trade designation Zeodent 165, Irish moss, iota- carrageenan, gum tragacanth, and polyvinylpyrrolidone.
  • inorganic thickening silicas such as amorphous silicas available from Evonik under the trade designation Zeodent 165, Irish moss, iota- carrageenan, gum tragacanth, and polyvinylpyrrolidone.
  • compositions according to the invention preferably comprise a polymeric deposition aid.
  • the composition comprises acid anhydride polymers, particularly preferred are copolymers of maleic anhydride with methyl vinylether, in which the anhydride moiety may be in a partially or fully hydrolysed or alcoholysed form.
  • Preferred copolymers include Gantrez(R) polymers such as:
  • Gantrez S-95 molecular weight 216,000; free acid
  • Gantrez S-96 molecular weight 700,000; free acid
  • compositions according to the invention may comprise a tooth whitening agent.
  • the whitening agent preferably comprises a green and/or a blue pigment.
  • a pigment is generally understood to be a shade/material which is insoluble in the relevant medium, at the relevant temperature. This is in contrast to dyes which are soluble.
  • the "relevant medium” is human saliva, the liquid medium in which the composition is used, at the temperature of the oral cavity during brushing of the teeth, i.e. up to 37 Degrees C.
  • the relevant medium may be considered to be water and the relevant temperature to be 25 Degrees C.
  • the blue pigment is Pigment Blue 15, more preferably Pigment Blue 15:1, 15:2, 15:3, 15:4, 15:5 or 15:6, most preferably 15:1.
  • a preferred pigment is blue pigment is Phthalocyanine Blue Pigment, Cl No. 74160, blue covarine.
  • the preferred Green pigment is Phthalocyanine Green, preferably Phthalocyanine Green CI- 74260.
  • the total level of pigment in the composition is from 0.01 wt% to 3 wt%, more preferably from 0.02 to 2 wt%.
  • composition is a toothpaste it may be a dual phase paste, with the whitening pigments present in one phase.
  • compositions according to the invention may comprise water-soluble or sparingly water-soluble sources of metal salts
  • zinc ions such as zinc chloride, zinc acetate, zinc gluconate, zinc sulphate, zinc fluoride, zinc citrate, zinc lactate, zinc oxide, zinc monoglycerolate, zinc tartrate, zinc pyrophosphate and zinc maleate
  • stannous ions such as stannous fluoride and stannous chloride.
  • compositions according to the invention may comprise oral care enzyme systems such as hydrogen peroxide producing enzyme systems (e.g. the oxidoreductase enzyme glucose oxidase), amyloglucosidase, dextranase and/or mutanase, (optionally in the presence of zinc ion providing compounds and/or 8- hydroxyquinoline derivatives), lactoperoxidase, lactoferrin, lysozyme and mixtures thereof.
  • Compositions of the invention may comprise fluoride sources such as sodium fluoride, stannous fluoride, sodium monofluorophosphate, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride, cobalt ammonium fluoride and mixtures thereof.
  • composition according to the invention will comprise further ingredients which are common in the art, such as: antimicrobial agents, e.g. chlorhexidine, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, ethyl lauroyl arginate, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis-(4-chloro-6-bromophenol); anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.; anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein; plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates; vitamins such as
  • binders and thickeners such as sodium carboxymethyl-cellulose, hydroxyethyl cellulose (Natrosol®), xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol®; polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included; buffers and salts to buffer the pH and ionic strength of the oral care composition; and other optional ingredients that may be included are e.g. bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • Examples of the invention are referred to by a number and comparative Examples by a letter.
  • Composition according to the invention was applied to the teeth prior to placement of a retainer the teeth.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Un procédé d'atténuation d'un endommagement de l'émail provoqué par le port d'un aligneur dentaire comprenant l'étape d'application sur les dents d'une composition de soin buccodentaire comprenant : a) du silicate de calcium et ; b) du sel de phosphate de sodium.
PCT/EP2023/065987 2022-06-23 2023-06-14 Composition de soin buccodentaire pour atténuer et/ou inverser l'érosion de l'émail dentaire provoquée par l'usure d'un aligneur WO2023247290A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22180655.7 2022-06-23
EP22180655 2022-06-23

Publications (1)

Publication Number Publication Date
WO2023247290A1 true WO2023247290A1 (fr) 2023-12-28

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PCT/EP2023/065987 WO2023247290A1 (fr) 2022-06-23 2023-06-14 Composition de soin buccodentaire pour atténuer et/ou inverser l'érosion de l'émail dentaire provoquée par l'usure d'un aligneur

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236070A2 (fr) 1986-02-28 1987-09-09 Unilever Plc Silices
US20120315228A1 (en) * 2010-03-09 2012-12-13 Yan Deng Stable oral care compositions
WO2019034325A1 (fr) * 2017-08-18 2019-02-21 Unilever N.V. Composition pour soins buccaux
US10406078B2 (en) * 2016-11-18 2019-09-10 Pac-Dent International, Inc. Nano-complexes for enamel remineralization
US20200093576A1 (en) * 2018-09-24 2020-03-26 3M Innovative Properties Company Dental appliance with cosmetic therapeutic aqueous solution

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236070A2 (fr) 1986-02-28 1987-09-09 Unilever Plc Silices
US20120315228A1 (en) * 2010-03-09 2012-12-13 Yan Deng Stable oral care compositions
US10406078B2 (en) * 2016-11-18 2019-09-10 Pac-Dent International, Inc. Nano-complexes for enamel remineralization
WO2019034325A1 (fr) * 2017-08-18 2019-02-21 Unilever N.V. Composition pour soins buccaux
US20200093576A1 (en) * 2018-09-24 2020-03-26 3M Innovative Properties Company Dental appliance with cosmetic therapeutic aqueous solution

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GNPD [online] MINTEL; 23 May 2022 (2022-05-23), ANONYMOUS: "Advanced Toothpaste", XP055973568, retrieved from https://www.gnpd.com/sinatra/recordpage/9605900/ Database accession no. 9605900 *
HORNBY KATE ET AL: "Enhanced enamel benefits from a novel toothpaste and dual phase gel containing calcium silicate and sodium phosphate salts", CHLORHEXIDINE AND GREEN TEA EXTRACT REDUCE DENTIN EROSION AND ABRASION IN SITU,, vol. 42 Suppl 1, 1 June 2014 (2014-06-01), pages S39 - S45, XP002795362, ISSN: 1879-176X, DOI: 10.1016/S0300-5712(14)50006-1 *
YAN DONG ET AL: "Changes in the Microbiome of the Inner Surface of Clear Aligners After Different Usage Periods", CURRENT MICROBIOLOGY, vol. 78, no. 2, 3 January 2021 (2021-01-03), pages 566 - 575, XP037357077, ISSN: 0343-8651, DOI: 10.1007/S00284-020-02308-5 *

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