WO2023186648A1 - Composition de soin buccodentaire - Google Patents

Composition de soin buccodentaire Download PDF

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Publication number
WO2023186648A1
WO2023186648A1 PCT/EP2023/057293 EP2023057293W WO2023186648A1 WO 2023186648 A1 WO2023186648 A1 WO 2023186648A1 EP 2023057293 W EP2023057293 W EP 2023057293W WO 2023186648 A1 WO2023186648 A1 WO 2023186648A1
Authority
WO
WIPO (PCT)
Prior art keywords
oral care
care composition
aqueous oral
composition according
composition
Prior art date
Application number
PCT/EP2023/057293
Other languages
English (en)
Inventor
David Thomas Littlewood
Robert George Riley
Original Assignee
Unilever Ip Holdings B.V.
Unilever Global Ip Limited
Conopco, Inc., D/B/A Unilever
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Ip Holdings B.V., Unilever Global Ip Limited, Conopco, Inc., D/B/A Unilever filed Critical Unilever Ip Holdings B.V.
Publication of WO2023186648A1 publication Critical patent/WO2023186648A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/31—Anhydrous

Definitions

  • the present invention is concerned with non-aqueous oral care compositions.
  • Oral care compositions such as dentifrices typically contain dentally acceptable abrasive, humectant, water, and water-soluble polymer which serves as a thickener and binder for the ingredients.
  • dentally acceptable abrasive, humectant, water, and water-soluble polymer which serves as a thickener and binder for the ingredients.
  • other ingredients such as flavours, sweeteners, preservatives and fluoride are also utilized at low levels.
  • Non-aqueous formulations have been suggested as a way of improving the stability of these materials.
  • W096/03108 describes a non-aqueous dentifrice composition comprising a carboxyvinyl polymer, a humectant, a polyethylene glycol and a dentally acceptable abrasive.
  • EP 2585031 discloses a non-aqueous oral care composition with a liquid continuous phase comprising a thickening agent, a humectant, and one or more liquid polyethylene glycols having a melting point below 25°C, in which the liquid continuous phase is structured with crystals of one or more solid polyethylene glycols having a melting point of 25°C or above.
  • a first aspect of the invention relates to a non-aqueous oral care composition
  • a non-aqueous oral care composition comprising: i) greater than 50 wt% of an organic polyol having 3 or more hydroxyl groups in the molecule; ii) a carrageenan; iii) an anionic surfactant comprising at least 50wt% of the total anionic surfactant of an alkyl sulphate based surfactant; iv) a mixture of a calcium silicate and a phosphate source which, when delivered to the teeth results in the in situ generation of hydroxyapatite on teeth.
  • composition of the invention is non-aqueous.
  • non-aqueous it is generally meant that water is not deliberately added to the composition in any significant quantity.
  • nonaqueous does not mean that small amounts of water cannot be present, for example as a consequence of its association with hygroscopic raw materials.
  • non-aqueous generally means that water is present in an amount no greater than 5%, more preferably no greater than 3% most preferably no greater than 1 % by weight based on the total weight of the composition.
  • Compositions according to the invention comprise carrageenan preferably at weight ratios of 1 :2 to 2:1 iota to kappa carrageenan.
  • the carrageenan present in the composition of the invention preferably consists from 33wt% to 66wt% of the total level of iota carrageenan and 33 wt% to 66 wt% of kappa carrageenan.
  • the total level of carrageenan is from 0.01 to 1 wt% of the total composition, more preferably 0.05 to 0.5 wt% most preferably 0.08 to 0.25 wt%.
  • composition of the invention comprise polyethylene glycol or polypropylene glycol having a melting point below 42°C, more preferably below 25°C.
  • melting point is greater than -20°C and ranges from -15 to 25°C, more preferably from -5 to 8°C, most preferably from 4 to 8°C.
  • Preferred liquid polyethylene glycols have an average value of n in the general formula H(OCH 2 CH 2 ) n OH (as described above) ranging from about 4 to 12, more preferably about 6 to 8, most preferably about 8.
  • the average molecular weight suitably ranges from about 190 to 630, more preferably from about 285 to 420, most preferably from about 380 to 420 g/mol.
  • Suitable commercially available materials include for example PEG 400 (ex BDH Chemicals). Mixtures of any of the above described materials may also be used.
  • the amount of polyethylene glycol of polyethylene glycol and/or polypropylene glycol iii (as defined above) in compositions of the invention suitably ranges from 0.1 to 10 wt% of the total composition, more preferably 0.5 to 7wt% most preferably 1 to 5 wt% on the total weight of the composition.
  • the preferred ratio of polyethylene glycol and/or polypropylene glycol iii) to carrageenan is from 1 :200 to 1 :4, preferably from 1 : 1 to 1 :40.
  • compositions of the invention comprise organic polyols having 3 or more hydroxyl groups in the molecule (hereinafter termed “organic polyols”).
  • organic polyols examples include glycerol, sorbitol, xylitol, mannitol, lactitol, maltitol, erythritol, and hydrogenated partially hydrolyzed polysaccharides.
  • the most preferred organic polyol is glycerol. Mixtures of any of the above described materials may also be used.
  • the level of organic polyol will depend on the particular type chosen, but generally ranges from about 20 to 90% by weight based on the total weight of the composition, the amount of organic polyol suitably ranges from 35 to 85%, more preferably from 65 to 80% by total weight organic polyol based on the total weight of the composition.
  • the composition of the invention is glycerol-based (i.e. glycerol makes up a higher portion of the composition's weight than any other compound) and contains from 55 to 80% by weight glycerol based on the total weight of the composition.
  • compositions of the invention comprise an anionic surfactants, preferably an at least 50wt% of the total anionic surfactant of an alkyl sulphate based surfactant.
  • anionic surfactant is sodium lauryl sulphate.
  • the level of anionic surfactant is from 0.1 to 5 wt%, preferably 0.5 to 3 wt% of the total composition.
  • Additional surfactants such as nonionic, cationic and zwitterionic or amphoteric surfactants are preferably present at a level below 0.5 wt of the total composition, preferably less than 0.1 wt% of the composition.
  • composition of the invention is used to preferably used to clean the surfaces of the oral cavity and is known as an oral care composition.
  • compositions of the invention are those which are suitable for brushing and/or rinsing the surfaces of the oral cavity.
  • the composition of the invention is most preferably in the form of a toothpaste.
  • a composition is not intentionally swallowed for purposes of systemic administration of therapeutic agents, but is applied to the oral cavity, used to treat the oral cavity and then expectorated.
  • a cleaning implement such as a toothbrush, usually by applying it to the bristles of the toothbrush and then brushing the accessible surfaces of the oral cavity.
  • the dentifrice/toothpaste is in the form of an extrudable semi-solid such as a cream, paste or gel (or mixture thereof).
  • compositions according to the invention will generally contain further ingredients to enhance performance and/or consumer acceptability, in addition to the ingredients specified above.
  • Compositions according to the invention particularly toothpastes, preferably comprise particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalcium phosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
  • the composition particularly a toothpaste, comprises a silica based abrasive.
  • the preferred abrasive silicas used in the present invention is a silica with a low refractive index. It may be used as the sole abrasive silica, or in conjunction with a low level of other abrasive silicas, e.g. those according to EP 236070.
  • the low refractive index silicas, used as abrasives in the present invention are preferably silicas with an apparent refractive index (R.l.) in the range of 1.41 - 1 .47, preferably 1 .435 - 1.445, preferably having a weight mean particle size of between 5 and 15 mm, a BET (nitrogen) surface area of between 10 and 100 m 2 /g and an oil absorption of about 70 - 150 cm 3 /100 g, but abrasive silicas with a lower apparent refractive index may also be used.
  • suitable low refractive index abrasive silicas e.g. having an R.l.
  • silicas of between 1.435 and 1.445 are Tixosil 63 and 73 ex Rhone Poulenc; Sident 10 ex Degussa; Zeodent 113 ex Zeofinn; Zeodent 124 ex Evonik, Sorbosil AC 77 ex PQ Corporation (having an R.l. of approximately 1 .440).
  • the amount of these silicas in the composition generally ranges from 5-60% by weight, usually 5-20% by weight.
  • composition particularly if a toothpaste preferably comprises an inorganic or a natural or synthetic thickener or gelling agent in proportions of about 0.10 to about 15% by weight depending on the material chosen.
  • thickeners in the dentifrice compositions of the present invention form an extrudable, shape-retaining product which can be squeezed from a tube onto a toothbrush and will not fall between the bristles of the brush but rather, will substantially maintain its shape thereon.
  • Suitable thickeners or gelling agents useful in the practice of the present invention include inorganic thickening silicas such as amorphous silicas available from Huber Corporation under the trade designation Zeodent 165, Irish moss, iota-carrageenan, gum tragacanth, and polyvinylpyrrolidone.
  • inorganic thickening silicas such as amorphous silicas available from Huber Corporation under the trade designation Zeodent 165, Irish moss, iota-carrageenan, gum tragacanth, and polyvinylpyrrolidone.
  • compositions according to the invention preferably comprise a polymeric deposition aid.
  • the composition comprises acid anhydride polymers, particularly preferred are co-polymers of maleic anhydride with methyl vinylether, in which the anhydride moiety may be in a partially or fully hydrolysed or alcoholysed form.
  • Preferred copolymers include Gantrez(R) polymers such as: Gantrez S-95: molecular weight 216,000; free acid;
  • Gantrez S-96 molecular weight 700,000; free acid
  • Gantrez S-97 molecular weight 1 ,500,000; free acid
  • Gantrez MS-955 molecular weight 1,060,000; calcium/sodium salt.
  • Particularly preferred co-polymers of maleic acid and methyl vinylether have a molecular weight of 1 ,000,000 or greater and an especially preferred material is Gantrez S-97.
  • compositions according to the invention may comprise a tooth whitening agent.
  • the whitening agent preferably comprises a green and/or a blue pigment.
  • a pigment is generally understood to be a shade/material which is insoluble in the relevant medium, at the relevant temperature. This is in contrast to dyes which are soluble.
  • the "relevant medium” is human saliva, the liquid medium in which the composition is used, at the temperature of the oral cavity during brushing of the teeth, i.e. up to 37 Degrees C. As a reasonable approximation, the relevant medium may be considered to be water and the relevant temperature to be 25 Degrees C.
  • the blue pigment is Pigment Blue 15, more preferably Pigment Blue 15:1, 15:2, 15:3, 15:4, 15:5 or 15:6, most preferably 15:1.
  • a preferred pigment is blue pigment is Phthalocyanine Blue Pigment, Cl No. 74160, blue covarine.
  • the preferred Green pigment is Phthalocyanine Green, preferably Phthalocyanine Green CI-74260.
  • the total level of pigment in the composition is from 0.01 wt% to 3 wt, more preferably from 0.02 to 2 wt%.
  • composition is a toothpaste it may be a dual phase paste, with the whitening pigments present in one phase.
  • compositions according to the invention may comprise water-soluble or sparingly water-soluble sources of metal salts
  • zinc ions such as zinc chloride, zinc acetate, zinc gluconate, zinc sulphate, zinc fluoride, zinc citrate, zinc lactate, zinc oxide, zinc monoglycerolate, zinc tartrate, zinc pyrophosphate and zinc maleate
  • stannous ions such as stannous fluoride and stannous chloride.
  • compositions according to the invention may comprise oral care enzyme systems such as hydrogen peroxide producing enzyme systems (e.g. the oxidoreductase enzyme glucose oxidase), amyloglucosidase, dextranase and/or mutanase, (optionally in the presence of zinc ion providing compounds and/or 8- hydroxyquinoline derivatives), lactoperoxidase, lactoferrin, lysozyme and mixtures thereof;
  • hydrogen peroxide producing enzyme systems e.g. the oxidoreductase enzyme glucose oxidase
  • amyloglucosidase e.g. the oxidoreductase enzyme glucose oxidase
  • dextranase and/or mutanase e.g. the oxidoreductase enzyme glucose oxidase
  • mutanase e.g. the mutanase
  • lactoperoxidase e.g. the
  • Compositions of the invention may comprise fluoride sources such as sodium fluoride, stannous fluoride, sodium monofluorophosphate, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride, cobalt ammonium fluoride and mixtures thereof.
  • fluoride sources such as sodium fluoride, stannous fluoride, sodium monofluorophosphate, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride, cobalt ammonium fluoride and mixtures thereof.
  • compositions of the invention includes agents for the remineralisation of teeth.
  • remineralisation in the context of the present invention means the in situ generation of hydroxyapatite on teeth.
  • Theagent for the remineralisation of teeth is calcium silicate and a phosphate source which, when delivered to the teeth results in the in situ generation of hydroxyapatite on teeth.
  • the amount of calcium silicate in the composition of the invention typically ranges from 1 to 30%, preferably from 5 to 20% by total weight of the oral care composition.
  • remineralising phosphate sources include, for example, monosodium dihydrogen phosphate, disodium hydrogen phosphate, sodium pyrophosphate, tetrasodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, potassium dihydrogenphosphate, trisodium phosphate, tripotassium phosphate and mixtures thereof.
  • the remineralising phosphate source is a mixture of trisodium phosphate and sodium dihydrogen phosphate.
  • the amount of remineralising phosphate source(s) (e.g. trisodium phosphate and sodium dihydrogen phosphate) in the composition of this invention typically ranges from 2 to 15%, preferably from 4 to 10% by total weight remineralising phosphate source based on the total weight of the oral care composition.
  • composition according to the invention will comprise further ingredients which are common in the art, such as: antimicrobial agents, e.g. chlorhexidine, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; cetylpyridium chloride clay complex bis- guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis-(4-chloro-6-bromophenol); anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.; anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein; plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates; vitamins such as Vitamins
  • Humectants such as glycerol, sorbitol, propylene glycol, xylitol, lactitol etc.; binders and thickeners such as sodium carboxymethyl-cellulose, hydroxyethyl cellulose (Natrosol®), xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol®; polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included; buffers and salts to buffer the pH and ionic strength of the oral care composition; and other optional ingredients that may be included are e.g. bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/ci
  • Viscosity was measured fresh from batch and ribbon assessments were taken at 24 hrs
  • Example according to the invention demonstrate the Example according to the invention have the most consumer acceptable ribbon height and viscosity after storage.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de soin buccodentaire non aqueuse comprenant : i) plus de 50 % en poids d'un polyol organique ayant 3 groupes hydroxyles ou plus dans la molécule ; ii) un carraghénane ; iii) un tensioactif anionique comprenant au moins 50 % en poids du tensioactif anionique total d'un tensioactif à base de sulfate d'alkyle ; iv) un mélange d'un silicate de calcium et d'une source de phosphate, qui, lorsqu'elle est administrée au niveau des dents, conduit à la génération in situ d'hydroxyapatite sur les dents.
PCT/EP2023/057293 2022-04-01 2023-03-22 Composition de soin buccodentaire WO2023186648A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22166284.4 2022-04-01
EP22166284 2022-04-01

Publications (1)

Publication Number Publication Date
WO2023186648A1 true WO2023186648A1 (fr) 2023-10-05

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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585648A (en) * 1983-08-24 1986-04-29 Lion Corporation Dentifrice composition comprising zirconium-bonded synthetic amorphous silicate
EP0236070A2 (fr) 1986-02-28 1987-09-09 Unilever Plc Silices
WO1996003108A1 (fr) 1994-07-21 1996-02-08 Smithkline Beecham Plc Composition de dentifrice
US20030124067A1 (en) * 2001-11-28 2003-07-03 Jiang Yue Dentifrice compositions comprising a stable low water, phase comprising polyphosphate and ionic active ingredients
US20120020898A1 (en) * 2009-04-01 2012-01-26 Colgate-Palmolive Company Non-aqueous dentifrice composition with bioacceptable and bioactive glass and methods of use and manufacture thereof
US20120064017A1 (en) * 2009-06-03 2012-03-15 Colgate-Palmolive Company Borinic compositions
US20120315228A1 (en) * 2010-03-09 2012-12-13 Yan Deng Stable oral care compositions
EP2585031A1 (fr) 2010-06-23 2013-05-01 Unilever PLC Compositions non aqueuses de soins oraux
CN104027260A (zh) * 2014-06-20 2014-09-10 广州薇美姿个人护理用品有限公司 一种含有桃柘酚的口腔护理用品
WO2015158639A1 (fr) * 2014-04-17 2015-10-22 Unilever Plc Compositions solides pour l'hygiène bucco-dentaire
US20150366767A1 (en) * 2012-12-21 2015-12-24 Colgate-Palmolive Company Non-staining toothpaste

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585648A (en) * 1983-08-24 1986-04-29 Lion Corporation Dentifrice composition comprising zirconium-bonded synthetic amorphous silicate
EP0236070A2 (fr) 1986-02-28 1987-09-09 Unilever Plc Silices
WO1996003108A1 (fr) 1994-07-21 1996-02-08 Smithkline Beecham Plc Composition de dentifrice
US20030124067A1 (en) * 2001-11-28 2003-07-03 Jiang Yue Dentifrice compositions comprising a stable low water, phase comprising polyphosphate and ionic active ingredients
US20120020898A1 (en) * 2009-04-01 2012-01-26 Colgate-Palmolive Company Non-aqueous dentifrice composition with bioacceptable and bioactive glass and methods of use and manufacture thereof
US20120064017A1 (en) * 2009-06-03 2012-03-15 Colgate-Palmolive Company Borinic compositions
US20120315228A1 (en) * 2010-03-09 2012-12-13 Yan Deng Stable oral care compositions
EP2585031A1 (fr) 2010-06-23 2013-05-01 Unilever PLC Compositions non aqueuses de soins oraux
US20150366767A1 (en) * 2012-12-21 2015-12-24 Colgate-Palmolive Company Non-staining toothpaste
WO2015158639A1 (fr) * 2014-04-17 2015-10-22 Unilever Plc Compositions solides pour l'hygiène bucco-dentaire
CN104027260A (zh) * 2014-06-20 2014-09-10 广州薇美姿个人护理用品有限公司 一种含有桃柘酚的口腔护理用品

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