WO2020210993A1 - Produits mélangés et séparés de résine et de baume pour dispositif d'aérosol, et leur procédé de préparation - Google Patents

Produits mélangés et séparés de résine et de baume pour dispositif d'aérosol, et leur procédé de préparation Download PDF

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Publication number
WO2020210993A1
WO2020210993A1 PCT/CN2019/082929 CN2019082929W WO2020210993A1 WO 2020210993 A1 WO2020210993 A1 WO 2020210993A1 CN 2019082929 W CN2019082929 W CN 2019082929W WO 2020210993 A1 WO2020210993 A1 WO 2020210993A1
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WO
WIPO (PCT)
Prior art keywords
acid
resin
formulation
balsam
plant
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Application number
PCT/CN2019/082929
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English (en)
Chinese (zh)
Inventor
姜兴涛
熊赞华
许静
闻一龙
Original Assignee
深圳雾芯科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 深圳雾芯科技有限公司 filed Critical 深圳雾芯科技有限公司
Priority to PCT/CN2019/082929 priority Critical patent/WO2020210993A1/fr
Publication of WO2020210993A1 publication Critical patent/WO2020210993A1/fr

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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances

Definitions

  • the invention belongs to the technical field of tobacco, and specifically relates to a resin balsam separation formulation for an aerosol device and a preparation method thereof.
  • the nicotine will cause greater irritation to the mouth and throat during inhalation, resulting in poor sensory quality and reducing consumer experience; at the same time, In the actual suction process, because of the poor experience, the proportion of nicotine that actually enters the throat is less, and more nicotine is absorbed through the nasal cavity and oral cavity, or directly exhaled, which slows down the absorption rate of nicotine and also reduces the actual intake of nicotine. , It is difficult to meet consumers' demands for satisfaction.
  • the object of the present invention is to provide a resin balsam separation formulation for aerosol devices and a preparation method thereof.
  • the separation formulation can effectively reduce the irritation of nicotine to the oral cavity and throat and improve Consumer experience: As the ratio of nicotine entering the throat increases, the absorption rate and actual intake of nicotine will also increase.
  • the isolated formulation also has the effect of aromatic resuscitation, can regulate the permeability of the blood-brain barrier, and can increase the nicotine The bioavailability of it produces greater physiological satisfaction.
  • the present invention provides a formulation that can be used in an aerosol device to produce inhalation aerosol.
  • the formulation includes plant resin balsam and its extraction and separation products and carrier; said plant resin balm includes benzoin, sage, frankincense, One or more of Myrrh, Dragon's Blood, Asafoetida, Rosin, Tulu and Peru;
  • the extraction and separation products of the plant resin balsam include, but are not limited to, extracts, tinctures, extracts, pure oils, extracts, tinctures, extracts, pure oils, extracts, tinctures, extracts, pure oils, extracts, tinctures, extracts obtained from the plant resin balsams with solvents, or distillation, dry distillation, extraction, rectification or sublimation processes Essential oils and distillates, as well as resin acids, resin salts, volatile oils and monomer components obtained from chromatography, molecular distillation, rectification, separation, hydrolysis, precipitation, filtration, crystallization or saponification.
  • the plant resin balm can well balance the alkaline stimulating effect of nicotine and improve satisfaction; the plant resin balm includes one or more of benzoin, sesame, tolu and Peru .
  • the resin acid includes, but is not limited to, benzoic acid, phenylacetic acid, cinnamic acid, ⁇ -phenylpropionic acid, threonic acid, rosin acid, boswellic acid, myrrhic acid, dehydroabietic acid and the like.
  • the resin acid salt includes, but is not limited to, benzoate, phenylacetate, cinnamate, ⁇ -phenylpropionate, thormonate, rosinate, boswellic acid salt, and Medicinal acid salts, dehydroabietic acid salts, etc.
  • the content of the plant resin balsam and its extraction and separation products in the formulation is 0.01-99.99 wt%.
  • the content of the plant resin balsam and its extraction and separation products in the formulation is 0.1-10 wt%, such as 0.5-5 wt%, 1-5 wt%, such as 1-3 wt%.
  • the content of the carrier in the formulation is 0.01-99.99 wt%.
  • the carrier includes but is not limited to propylene glycol, glycerin, water, ethanol and combinations thereof.
  • the formulation further includes nicotine, and the content of the nicotine in the formulation is 0-10% by weight, for example, 0.05% by weight, 0.1% by weight, 0.2% by weight, 0.5% by weight, 1.0% by weight, 2.0% by weight. wt%, 5.0 wt%, 8.0 wt%, or 10 wt%.
  • the formulation further includes other ingredients, including but not limited to flavors, food additives, nutritional supplements, tobacco extracts, pharmaceutical ingredients, and the like.
  • the plant includes all plant species that produce the resin balm.
  • the plants include, but are not limited to, Styrax tonkinensis (Pierre) Craib ex Hart., Styrax benzoin and Styrax paralleloneurum; Liquidambar plant Liquidumbar orientalis Mill.; Boswellia carterii Birdw. and Boswellia bhaurdajiana Birdw.; Commiphora myrrha Engl.
  • Dracaena genus Daemonorops draco Blume. Cambodian dragon tree Dracaena Cambodian Pierre and dragon blood tree Dracachy omega Pterocarpus draco L.
  • Croton croton Croton draco Schlecht. Croton hibiscifolius Kunth, and Croton gossypiifolius Vahl[C. sanguifluus HBet K.
  • the present invention also provides a method for preparing the above formulation, the method comprising:
  • the plant resin balsam and its extraction and separation product, carrier, optionally nicotine and other components are mixed to prepare the formulation.
  • the plant resin balm includes, but is not limited to, substances volatilized from plant trunks or stems, substances exuded from plant trunks or bark, substances exuded from plant fruits, cuts from plant trunks or stems The effluent material, and the dried product of the above material.
  • the extraction and separation products of the plant resin balsam include, but are not limited to, extracts obtained from extraction processes such as steam distillation, solvent extraction, supercritical extraction, ultrasonic assisted extraction, microwave assisted extraction, dry distillation, rectification, and sublimation. , Tinctures, extracts, pure oils, essential oils, distillates and other products, as well as resin acids, resinates, resin acids, resin salts, etc. obtained by separation and purification processes such as chromatography, molecular distillation, rectification, hydrolysis, saponification, precipitation, filtration, and crystallization. Volatile oil and monomer components.
  • dry distillation, hydrolysis or saponification processes are used.
  • the dry distillation includes, but is not limited to, dry distillation and pyrolysis of the plant resin balsam in a closed or semi-closed system at 100°C to 400°C under aerobic or anaerobic conditions.
  • the solvent can be a polar solvent or a non-polar solvent and a mixed solvent thereof.
  • a polar solvent or a non-polar solvent and a mixed solvent thereof.
  • Exemplary including but not limited to water, methanol, ethanol, acetone, ethyl acetate, propane, butane, n-pentane, n-hexane, cyclohexane, dichloromethane, chloroform, petroleum ether, diethyl ether, tetrahydrofuran At least one of them.
  • the hydrolysis is hydrolysis under acidic, neutral and alkaline conditions.
  • the hydrolysis includes but is not limited to plant resin balsam in a system containing water, without adding other ingredients or adding acids, alkalis, weak acid salts, weak alkali salts and other ingredients that affect the pH of the system.
  • the pH value of the system is 0-14 In between, the reaction is carried out at a temperature of 10°C to 120°C.
  • the saponification includes but is not limited to plant resin balsam in a system containing water, adding alkali, weak acid salt and other components that affect the pH of the system.
  • the pH of the system is between 7-14 and the temperature is 10°C. Reactions carried out at ⁇ 120°C.
  • acids may be used in the process of hydrolysis and saponification.
  • the acids include but are not limited to mineral acids such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, and formic acid, acetic acid, propionic acid, lactic acid, benzoic acid, Organic acids such as phenylacetic acid, malonic acid, malic acid, citric acid, salicylic acid, and tartaric acid.
  • Alkali may be used in the hydrolysis and saponification process, and the alkali includes, but is not limited to, inorganic alkalis such as sodium hydroxide, potassium hydroxide, and ammonia, and organic alkalis such as nicotine and caffeine.
  • weak acid salts may be used in the hydrolysis and saponification process.
  • the weak acid salts include but are not limited to sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium bicarbonate, phosphoric acid Disodium hydrogen, sodium dihydrogen phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate.
  • Weak alkali salts may be used in the hydrolysis and saponification process, where the weak alkali salts include but are not limited to ammonium sulfate, ammonium hydrogen sulfate, ammonium chloride, and the like.
  • the present invention also provides the use of the above formulation, which is used in an aerosol device to generate an inhalable aerosol when the formulation is heated.
  • the present invention provides a resin balsam separation formulation for an aerosol device and a preparation method thereof, which comprises benzoin resin, sage resin, frankincense, myrrh, dragon's blood, asafoetida, rosin and other resins, tolu balsam, Peru balsam, etc.
  • a resin balsam separation formulation for an aerosol device and a preparation method thereof, which comprises benzoin resin, sage resin, frankincense, myrrh, dragon's blood, asafoetida, rosin and other resins, tolu balsam, Peru balsam, etc.
  • One or more of the balsam, or the extraction and separation product derived from the above-mentioned resin balsam Compared with the prior art in which no resin balsam is added or only a small amount of resin balsam is added for the purpose of enhancing fragrance, the present invention adds resin balsam and its separated components, resin balsam and its separation
  • Figure 1 is a schematic diagram of the test results of Example 4.
  • Figure 2 is a schematic diagram of the test results of Example 5.
  • Figure 3 is a schematic diagram of the test results of Example 6.
  • Suhexiang resin derived from Liquidambar serrata tree put 100g of Suhexiang resin derived from Liquidambar serrata tree in a heating container, heat it to 150°C, and collect the sublimation at the outlet of the container to obtain 3g of Suhexiang extract.
  • benzoin extract benzoin resin acid
  • sesame extract is dissolved in propylene glycol, and then other components, glycerin, and nicotine are sequentially added to obtain a resin separation formulation.
  • Boswellia resin Add 50 g of Boswellia resin to 500 g of ethyl acetate, stir and extract for 2 hours, filter, and concentrate the filtrate in vacuum until there is no residual solvent to obtain 10 g of Boswellia extract.
  • frankincense resin myrrh resin, dragon's blood resin, ferula resin, rosin resin, frankincense extract, myrrh extract, dragon's blood absolute, ferula tincture, and rosin volatile oil are dissolved in propylene glycol, and then other ingredients are added in sequence , Glycerin and nicotine to obtain resin separation formulation.
  • the concentrated sulfuric acid aqueous solution diluted to 20% was slowly added dropwise to the continuously stirred filtrate until the pH value of the liquid reached 3. Suction filtration, precipitation and drying, to obtain 20 g of Peruvian balsam extract.
  • Example 4 The effect of adding resin separation formulations on aerosol consumer experience
  • the left column is the control example
  • the right column is the example.
  • the formulation of benzoin resin acid is added.
  • the fineness of the smoke, the consistency of the fragrance, and the taste The four dimensions of sweetness and removal of bad breath have been improved.
  • the improvement of irritation and burning sensation, and the improvement of the two dimensions of oral cleanliness after suction are more significant.
  • the throat hit feeling is reduced to a moderately acceptable level. degree.
  • Example 5 Effects of adding balsam separation formulations on aerosol consumer experience
  • the device is a honeycomb ceramic atomization, battery power 6.5W, without adding 0.5% Peru balsam distillate and 0.1% Tolu balsam (in the same proportion of propylene glycol As a control, 20 consumers were asked to rate the aerosol experience according to the dimensions in Table 1.
  • the left column is the control example
  • the right column is the example.
  • Peru balsam distillate and tolu balsam blends most of the dimensions have been improved in the consumer experience process , The improvement in irritation and burning sensation is more significant, and at the same time, it reduces the throat hit to a moderately acceptable level.
  • the device is a honeycomb ceramic atomization
  • the battery power is 6.5W
  • the formulation without 2% benzoin extract (substituting the same proportion of propylene glycol) is used as a control.
  • Ten volunteers were selected for suction (no nicotine from any source was ingested 12 hours before suction). Nicotine is a chemical stimulant. When ingested by the human body, it can increase the heart rate. Therefore, the change in heart rate can be used to reflect the amount and rate of absorption of nicotine by the human body.

Abstract

La présente invention concerne des produits mélangés et séparés de résine et de baume pour un dispositif d'aérosol, et un procédé de préparation associé, la formulation comprenant une ou plusieurs résines comprenant de la résine de benjoin, de la résine de Liquidambar orientalis Mill., de l'encens, de la myrrhe, du sang de dragon, de l'ase fétide, de la colophane et analogues, et un ou plusieurs baumes tels que le baume de Tolu, le baume du Pérou, et analogues, ou la formulation étant issue des extraits et des séparations des résines et des baumes susmentionnés. En comparaison à l'état de la technique dans lequel des résines et des baumes ne sont pas ajoutés ou ne sont ajoutés qu'en petites quantités dans le but d'améliorer l'arôme, dans la présente invention, au moyen de l'ajout de résines et de baumes et de leurs constituants séparés dans un produit mélangé pour un dispositif d'aérosol, des constituants tels que des acides résiniques dans les résines et les baumes et leurs extraits peuvent réduire l'irritation provoquée par la nicotine dans la bouche et la gorge, et des esters dans les résines et les baumes et leurs extraits et d'autres constituants qui ne sont pas précisément qualitatifs peuvent améliorer la biodisponibilité de la nicotine.
PCT/CN2019/082929 2019-04-16 2019-04-16 Produits mélangés et séparés de résine et de baume pour dispositif d'aérosol, et leur procédé de préparation WO2020210993A1 (fr)

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PCT/CN2019/082929 WO2020210993A1 (fr) 2019-04-16 2019-04-16 Produits mélangés et séparés de résine et de baume pour dispositif d'aérosol, et leur procédé de préparation

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PCT/CN2019/082929 WO2020210993A1 (fr) 2019-04-16 2019-04-16 Produits mélangés et séparés de résine et de baume pour dispositif d'aérosol, et leur procédé de préparation

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015000125A1 (fr) * 2013-07-02 2015-01-08 吉瑞高新科技股份有限公司 Cigarette électronique
WO2016171997A2 (fr) * 2015-04-21 2016-10-27 Viriyapanthu Paul Composition de tabac sans fumée, procédé et appareil de vaporisation
CN107183787A (zh) * 2017-06-30 2017-09-22 云南中烟工业有限责任公司 一种具有雾化功能的感官材料抽吸装置
CN207023244U (zh) * 2017-06-30 2018-02-23 云南中烟工业有限责任公司 一种具有雾化功能的感官材料抽吸装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015000125A1 (fr) * 2013-07-02 2015-01-08 吉瑞高新科技股份有限公司 Cigarette électronique
WO2016171997A2 (fr) * 2015-04-21 2016-10-27 Viriyapanthu Paul Composition de tabac sans fumée, procédé et appareil de vaporisation
CN107183787A (zh) * 2017-06-30 2017-09-22 云南中烟工业有限责任公司 一种具有雾化功能的感官材料抽吸装置
CN207023244U (zh) * 2017-06-30 2018-02-23 云南中烟工业有限责任公司 一种具有雾化功能的感官材料抽吸装置

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