WO2020207296A1 - Apparatus for releasing animal intraosseous foreign particle - Google Patents
Apparatus for releasing animal intraosseous foreign particle Download PDFInfo
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- WO2020207296A1 WO2020207296A1 PCT/CN2020/082448 CN2020082448W WO2020207296A1 WO 2020207296 A1 WO2020207296 A1 WO 2020207296A1 CN 2020082448 W CN2020082448 W CN 2020082448W WO 2020207296 A1 WO2020207296 A1 WO 2020207296A1
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- outer cylinder
- particles
- foreign body
- cavity
- opening
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
Definitions
- the present invention relates to a device for releasing foreign body particles in animal bones.
- Prosthesis aseptic loosening refers to the aseptic inflammation induced by various micron particles (including metal particles, polyethylene particles, ceramic particles, etc.) that appear around the prosthesis after artificial joint replacement surgery and produced by the wear of the prosthesis This in turn induces osteolysis around the prosthesis and causes the prosthesis to loosen, which is the main long-term complication after artificial joint replacement surgery, which seriously affects the life of the artificial joint and the long-term quality of life of the patient.
- a release device for foreign body particles in animal bones comprising an outer cylinder with an opening at one end and a cavity communicating with the opening in the middle, and inducing particles formed from at least one component of an artificial joint are provided in the cavity
- the cylinder wall of the outer cylinder is provided with a plurality of release holes communicating with the cavity and having a diameter not less than the inducing particles.
- the opening of the outer cylinder is sealed by a sealing member.
- the inducing particles in the cavity can release the inducing particles into the bone tissue around the device through the release hole, thereby rapidly and stably inducing aseptic inflammation, thereby inducing osteolysis, and greatly accelerating the sterility of the prosthesis The process of loosening mechanism research and drug treatment research.
- the cylinder wall of the outer cylinder is evenly covered with the release holes.
- the induced particles are metal micron particles, polyethylene micron particles, ceramic micron particles, or the like.
- the seal is a screw, and an internal thread matching the screw is provided in the opening of the outer cylinder, and the screw rotates on the outer cylinder.
- the top of the screw is provided with a regular hexagonal groove that matches with a general orthopedic hexagonal screwdriver.
- the outer wall of the outer cylinder is a rough surface. Thereby increasing the friction after implantation and facilitating the fixation between the animal bone tissue and the cylinder wall.
- the device can be implanted into the joints or bones of experimental animals, and the induced particles are released around the device during the movement of the experimental animals through the release holes on the cylinder wall, thereby quickly and stably Induces aseptic inflammation, which in turn induces osteolysis, and becomes an animal model of aseptic loosening of the prosthesis in a few weeks.
- This provides a rapid prototyping carrier for studying the mechanism of aseptic loosening of the prosthesis and subsequent medical treatment, which greatly accelerates The process of research on prosthesis aseptic loosening mechanism and drug treatment research.
- FIG. 1 is an external view of the present invention.
- FIG. 2 is a cross-sectional view of the present invention.
- FIG. 3 is a schematic diagram of the structure of the screw of the present invention.
- a device for releasing foreign body particles in animal bones includes an outer cylinder 2.
- One end of the outer cylinder 2 is open, the other end is closed, and a cavity 21 communicating with the opening is provided in the middle.
- the cavity 21 is provided with inducing particles for inducing aseptic inflammation
- the barrel wall of the outer cylinder 2 is provided with a plurality of release holes 22 communicating with the cavity and having a diameter not less than the inducing particles.
- the induced particles are metal micron particles, polyethylene micron particles or ceramic micron particles, etc.
- the opening of the outer cylinder 2 is sealed by a seal.
- the seal is a screw 1, which is used as The cover seals the opening of the outer cylinder 2.
- the outer cylinder opening is provided with an internal thread 11 matching the screw 1.
- the screw 1 rotates on the outer cylinder 2, and the cylinder wall of the outer cylinder 2
- the release holes 22 are evenly covered, and the outer wall of the outer cylinder is a rough surface. This increases the friction after implantation and facilitates the fixation between the animal tissue and the cylinder wall.
- the top of the screw 1 is provided with a regular hexagonal groove that matches with a general orthopedic hexagonal screwdriver.
- the outer cylinder 2 is implanted in the above-mentioned hole. Since the diameter of the hole is slightly smaller than the diameter of the outer cylinder 2, the outer cylinder 2 can be fastened in the hole by a press-fitting manner. Then pour loosening-inducing particles (such as metal micron particles, polyethylene micron particles or ceramic micron particles, etc.) into the cavity 22 of the outer cylinder 2, and tighten the screw 1. Reposition the patella and close the incision layer by layer. Routine postoperative care: wound disinfection, antibiotics to prevent infection, etc. After the operation, the experimental animals moved freely. The loosening-inducing particles can be released around the outer tube 2 to induce aseptic inflammation and then osteolysis. A few weeks later, a prosthetic aseptic loosening animal model will be formed.
- loosening-inducing particles such as metal micron particles, polyethylene micron particles or ceramic micron particles, etc.
Abstract
An apparatus for releasing an animal intraosseous foreign particle, comprising an outer cylinder (2) having one end open and provided in the middle with a cavity (21) communicated with the opening. An inducing particle formed by at least one component in an artificial joint is provided in the cavity (21). A plurality of releasing holes (22) communicated with the cavity (21) and having a diameter not less than that of the inducing particle is arranged on the wall of the outer cylinder (2). The opening of the outer cylinder (2) is sealed by a seal member. The present apparatus can be used for the preparation and basic research of a prosthetic aseptic loosening animal model and has the characteristics of quickness, stability, and high repeatability.
Description
一种动物骨内异物颗粒释放装置 技术领域 Device for releasing foreign body particles in animal bones Technical field
[0001] 本发明涉及一种动物骨内异物颗粒释放装置。 [0001] The present invention relates to a device for releasing foreign body particles in animal bones.
背景技术 Background technique
[0002] 因骨关节系统疾病、 创伤引起关节疼痛和 /或关节功能障碍的患者， 一般都会 考虑接受人工关节置换术， 从而改善甚至恢复关节功能， 解除病痛。 但是部分 患者在接受人工关节置换术后， 会出现人工关节假体无菌性松动， 出现人工关 节活动时疼痛等症状。 假体无菌性松动是指人工关节置换术术后假体周围出现 的、 假体磨损产生的各种微米级颗粒 （包括金属颗粒、 聚乙烯颗粒、 陶瓷颗粒 等） 诱导下发生无菌性炎症， 进而诱发假体周围骨溶解导致假体松动， 是人工 关节置换术术后的主要远期并发症， 严重影响人工关节使用寿命和患者长期生 活质量， 而现有出现假体无菌性松动的患者不得不接受翻修手术以重新获得关 节运动功能， 但是这样的治疗方法治疗费用昂贵、 手术难度大。 为进一步研究 假体无菌性松动发生的相关机制， 从而尝试在松动发生早期进行干预以推迟 /避 免接受翻修手术、 治疗假体无菌性松动， 需在动物体内进行前期研究和动物实 验， 但是由于假体无菌性松动的现象需要长时间才能出现， 如何快速、 稳定、 可重复的模拟假体无菌性松动是现在亟待解决的问题。 [0002] Patients with joint pain and/or joint dysfunction caused by bone and joint system diseases and trauma generally consider receiving artificial joint replacement surgery to improve or even restore joint function and relieve pain. However, some patients will experience aseptic loosening of the artificial joint prosthesis and pain during artificial joint movement after artificial joint replacement. Prosthesis aseptic loosening refers to the aseptic inflammation induced by various micron particles (including metal particles, polyethylene particles, ceramic particles, etc.) that appear around the prosthesis after artificial joint replacement surgery and produced by the wear of the prosthesis This in turn induces osteolysis around the prosthesis and causes the prosthesis to loosen, which is the main long-term complication after artificial joint replacement surgery, which seriously affects the life of the artificial joint and the long-term quality of life of the patient. However, the existing aseptic loosening of the prosthesis Patients have to undergo revision surgery to regain joint motor function, but such treatments are expensive and difficult to operate. In order to further study the related mechanism of aseptic loosening of prosthesis, and try to intervene in the early stage of loosening to delay/avoid undergoing revision surgery and treat aseptic loosening of prosthesis, preliminary research and animal experiments are required in animals. As the aseptic loosening of the prosthesis takes a long time to appear, how to simulate the aseptic loosening of the prosthesis quickly, stably and reproducibly is a problem that needs to be solved urgently.
技术问题 technical problem
[0003] 如何快速、 稳定、 可重复的模拟假体无菌性松动是现在亟待解决的问题。 [0003] How to simulate the aseptic loosening of the prosthesis quickly, stably and reproducibly is a problem that needs to be solved urgently.
问题的解决方案 The solution to the problem
技术解决方案 Technical solutions
[0004] 本发明的目的通过采用下述技术方案予以实现： [0004] The purpose of the present invention is achieved by adopting the following technical solutions:
[0005] 一种动物骨内异物颗粒释放装置， 包括一端开口、 中部设有与开口连通的空腔 的外筒， 所述空腔内设有由人工关节中至少一种组成成分形成的诱导颗粒， 所 述外筒的筒壁上布设有多个与空腔连通、 且直径不小于所述诱导颗粒的释放孔 ， 所述外筒的开口通过密封件密封， 本装置植入动物骨内后， 在动物活动过程
中， 空腔内的诱导颗粒可通过所述释放孔将诱导颗粒释放到装置周围的骨组织 内， 从而快速、 稳定的诱发无菌性炎症， 进而诱发骨溶解， 大大加快了假体无 菌性松动机制研究和药物治疗研究的进程。 [0005] A release device for foreign body particles in animal bones, comprising an outer cylinder with an opening at one end and a cavity communicating with the opening in the middle, and inducing particles formed from at least one component of an artificial joint are provided in the cavity The cylinder wall of the outer cylinder is provided with a plurality of release holes communicating with the cavity and having a diameter not less than the inducing particles. The opening of the outer cylinder is sealed by a sealing member. After the device is implanted in the animal bone, During the animal activity The inducing particles in the cavity can release the inducing particles into the bone tissue around the device through the release hole, thereby rapidly and stably inducing aseptic inflammation, thereby inducing osteolysis, and greatly accelerating the sterility of the prosthesis The process of loosening mechanism research and drug treatment research.
[0006] 进一步的， 所述外筒的筒壁上均匀布满所述释放孔。 [0006] Further, the cylinder wall of the outer cylinder is evenly covered with the release holes.
[0007] 进一步的， 所述诱导颗粒为金属微米级颗粒、 聚乙烯微米级颗粒或陶瓷微米级 颗粒等。 [0007] Further, the induced particles are metal micron particles, polyethylene micron particles, ceramic micron particles, or the like.
[0008] 进一步的， 所述密封件为螺钉， 所述外筒开口内设有与所述螺钉匹配的内螺纹 ， 所述螺钉旋转在所述外筒上。 [0008] Further, the seal is a screw, and an internal thread matching the screw is provided in the opening of the outer cylinder, and the screw rotates on the outer cylinder.
[0009] 进一步的， 所述螺钉的顶部设有与骨科通用六边形螺丝起子相匹配的正六边形 凹槽。 [0009] Further, the top of the screw is provided with a regular hexagonal groove that matches with a general orthopedic hexagonal screwdriver.
[0010] 进一步的， 所述外筒的外壁为粗糙面。 从而增加植入后的摩擦力， 方便动物骨 组织与筒壁之间的固定。 [0010] Further, the outer wall of the outer cylinder is a rough surface. Thereby increasing the friction after implantation and facilitating the fixation between the animal bone tissue and the cylinder wall.
发明的有益效果 The beneficial effects of the invention
有益效果 Beneficial effect
[0011] 由于采用上述结构， 通过本装置可以植入实验动物的关节或骨头内， 通过筒壁 上的释放孔在实验动物活动过程中， 将诱导颗粒释放到装置的周围， 从而快速 、 稳定的诱发无菌性炎症， 进而诱发骨溶解， 数周后即成假体无菌性松动动物 模型， 这样对于研究假体无菌性松动形成机制和后续药物治疗提供了一个快速 成型的载体， 大大加快了假体无菌性松动机制研究和药物治疗研究的进程。 对附图的简要说明 [0011] Due to the above structure, the device can be implanted into the joints or bones of experimental animals, and the induced particles are released around the device during the movement of the experimental animals through the release holes on the cylinder wall, thereby quickly and stably Induces aseptic inflammation, which in turn induces osteolysis, and becomes an animal model of aseptic loosening of the prosthesis in a few weeks. This provides a rapid prototyping carrier for studying the mechanism of aseptic loosening of the prosthesis and subsequent medical treatment, which greatly accelerates The process of research on prosthesis aseptic loosening mechanism and drug treatment research. Brief description of the drawings
附图说明 Description of the drawings
[0012] 图 1为本发明的外观图。 [0012] FIG. 1 is an external view of the present invention.
[0013] 图 2为本发明的剖视图。 [0013] FIG. 2 is a cross-sectional view of the present invention.
[0014] 图 3为本发明螺钉的结构示意。 [0014] FIG. 3 is a schematic diagram of the structure of the screw of the present invention.
[0015] 图中： 1、 螺钉， 11、 螺纹， 2、 外筒， 21、 空腔， 22、 释放孔。 [0015] In the figure: 1. Screw, 11. Thread, 2. Outer cylinder, 21, Cavity, 22, Release hole.
实施该发明的最佳实施例 The best embodiment for implementing the invention
本发明的最佳实施方式
[0016] 下面结合附图和具体实例， 来详细说明一种动物骨内异物颗粒释放装置的具体 实施方式。 The best mode of the invention [0016] The following describes in detail a specific implementation of an animal bone foreign body particle release device with reference to the drawings and specific examples.
[0017] 如图 1至 3所示， 一种动物骨内异物颗粒释放装置， 包括外筒 2, 所述外筒 2的一 端开口、 另一端封闭、 且中部设有与开口连通的空腔 21， 所述空腔 21内设有用 于诱发无菌性炎症的诱导颗粒， 所述外筒 2的筒壁上布设有多个与空腔连通、 且 直径不小于所述诱导颗粒的释放孔 22, 所述诱导颗粒为金属微米级颗粒、 聚乙 烯微米级颗粒或陶瓷微米级颗粒等， 所述外筒 2的开口通过密封件密封， 本实施 例中， 所述密封件为螺钉 1， 螺钉 1作为盖体密封外筒 2的开口， 所述外筒开口内 设有与所述螺钉 1匹配的内螺纹 11， 所述螺钉 1旋转在所述外筒 2上， 所述外筒 2 的筒壁上均匀布满所述释放孔 22, 所述外筒的外壁为粗糙面。 从而增加植入后 的摩擦力， 方便动物组织与筒壁之间的固定。 所述螺钉 1的顶部设有与骨科通用 六边形螺丝起子相匹配的正六边形凹槽。 [0017] As shown in FIGS. 1 to 3, a device for releasing foreign body particles in animal bones includes an outer cylinder 2. One end of the outer cylinder 2 is open, the other end is closed, and a cavity 21 communicating with the opening is provided in the middle. , The cavity 21 is provided with inducing particles for inducing aseptic inflammation, and the barrel wall of the outer cylinder 2 is provided with a plurality of release holes 22 communicating with the cavity and having a diameter not less than the inducing particles. The induced particles are metal micron particles, polyethylene micron particles or ceramic micron particles, etc. The opening of the outer cylinder 2 is sealed by a seal. In this embodiment, the seal is a screw 1, which is used as The cover seals the opening of the outer cylinder 2. The outer cylinder opening is provided with an internal thread 11 matching the screw 1. The screw 1 rotates on the outer cylinder 2, and the cylinder wall of the outer cylinder 2 The release holes 22 are evenly covered, and the outer wall of the outer cylinder is a rough surface. This increases the friction after implantation and facilitates the fixation between the animal tissue and the cylinder wall. The top of the screw 1 is provided with a regular hexagonal groove that matches with a general orthopedic hexagonal screwdriver.
[0018] 使用时： 以膝关节假体无菌性松动模型为例。 将实验动物 （例如鼠、 兔、 犬等 ） 麻醉、 剃毛、 消毒、 铺巾铺单后， 切开膝部正中皮肤、 分离软组织和肌肉、 暴露并切开关节囊。 脱位髌骨， 在关节面负重区钻一直径略小于外筒 2直径、 深 度等同于整个装置长度的孔洞。 [0018] In use: Take the knee joint prosthesis aseptic loosening model as an example. After the experimental animals (such as rats, rabbits, dogs, etc.) are anesthetized, shaved, disinfected, and draped, the median skin of the knee is cut, the soft tissue and muscle are separated, and the nodular sac is exposed and cut. To dislocate the patella, drill a hole in the weight-bearing area of the joint surface with a diameter slightly smaller than the diameter of the outer cylinder 2 and a depth equal to the length of the entire device.
[0019] 将外筒 2植入上述孔洞内。 由于孔洞直径略小于外筒 2的直径， 故外筒 2可以以 压配方式紧固在孔洞内。 然后将松动诱导颗粒 （如金属微米级颗粒、 聚乙烯微 米级颗粒或陶瓷微米级颗粒等） 灌入外筒 2的空腔 22中， 拧紧螺钉 1。 复位髌骨 ， 逐层闭合切口。 术后常规护理： 伤口消毒， 抗生素预防感染等。 术后实验动 物自由活动。 松动诱导颗粒可释放至外筒 2周围， 诱发无菌性炎症， 进而诱发骨 溶解， 数周后即成假体无菌性松动动物模型。 [0019] The outer cylinder 2 is implanted in the above-mentioned hole. Since the diameter of the hole is slightly smaller than the diameter of the outer cylinder 2, the outer cylinder 2 can be fastened in the hole by a press-fitting manner. Then pour loosening-inducing particles (such as metal micron particles, polyethylene micron particles or ceramic micron particles, etc.) into the cavity 22 of the outer cylinder 2, and tighten the screw 1. Reposition the patella and close the incision layer by layer. Routine postoperative care: wound disinfection, antibiotics to prevent infection, etc. After the operation, the experimental animals moved freely. The loosening-inducing particles can be released around the outer tube 2 to induce aseptic inflammation and then osteolysis. A few weeks later, a prosthetic aseptic loosening animal model will be formed.
[0020] 上述为本发明的优选实施方式， 但所属领域的技术人员应该明白， 在不脱离所 附权利要求书所限定的本发明的精神和范围内， 在形式和细节上对本发明所作 出的各种变化， 都属于本发明的保护范围。 [0020] The above are the preferred embodiments of the present invention, but those skilled in the art should understand that the present invention is made in terms of form and details without departing from the spirit and scope of the present invention as defined by the appended claims. Various changes belong to the protection scope of the present invention.
发明实施例 Invention embodiment
本发明的实施方式 Embodiments of the invention
[0021] 在此处键入本发明的实施方式描述段落。
工业实用性 [0021] Type a paragraph describing the embodiment of the present invention here. Industrial applicability
[0022] 在此处键入工业实用性描述段落。 [0022] Type a paragraph describing industrial applicability here.
序列表自由内容 Sequence Listing Free Content
[0023] 在此处键入序列表自由内容描述段落。
[0023] Type the free content description paragraph of the sequence table here.
Claims
[权利要求 1] 一种动物骨内异物颗粒释放装置， 其特征在于： 包括一端开口、 中部 设有与开口连通的空腔的外筒， 所述空腔内设有由人工关节中至少一 种组成成分形成的诱导颗粒， 所述外筒的筒壁上布设有多个与空腔连 通、 且直径不小于所述诱导颗粒的释放孔， 所述外筒的开口通过密封 件密封。 [Claim 1] An animal bone foreign body particle release device, characterized in that it comprises an outer cylinder with an opening at one end and a cavity communicating with the opening in the middle, wherein the cavity is provided with at least one of artificial joints Inducing particles formed by the composition, a plurality of release holes communicating with the cavity and having a diameter not smaller than the inducing particles are arranged on the wall of the outer cylinder, and the opening of the outer cylinder is sealed by a seal.
[权利要求 2] 根据权利要求 1所述的动物骨内异物颗粒释放装置， 其特征在于： 所 述外筒的筒壁上均匀布满所述释放孔。 [Claim 2] The device for releasing foreign body particles in animal bones according to claim 1, wherein the wall of the outer cylinder is evenly covered with the release holes.
[权利要求 3] 根据权利要求 1所述的动物骨内异物颗粒释放装置， 其特征在于： 所 述诱导颗粒为均为微米级颗粒。 [Claim 3] The animal bone foreign body particle release device according to claim 1, characterized in that: the inducing particles are all micron-sized particles.
[权利要求 4] 根据权利要求 3所述的动物骨内异物颗粒释放装置， 其特征在于： 所 述诱导颗粒为金属微米级颗粒、 聚乙烯微米级颗粒或陶瓷微米级颗粒 [Claim 4] The animal bone foreign body particle release device according to claim 3, characterized in that: the induced particles are metal micron particles, polyethylene micron particles or ceramic micron particles
[权利要求 5] 根据权利要求 1所述的动物骨内异物颗粒释放装置， 其特征在于： 所 述密封件为螺钉， 所述外筒开口内设有与所述螺钉匹配的内螺纹， 所 述螺钉旋转在所述外筒上。 [Claim 5] The animal bone foreign body particle release device according to claim 1, characterized in that: the sealing member is a screw, and an internal thread matching the screw is provided in the opening of the outer cylinder, and The screw rotates on the outer cylinder.
[权利要求 6] 根据权利要求 5所述的动物骨内异物颗粒释放装置， 其特征在于： 所 述螺钉的顶部设有与骨科通用六边形螺丝起子相匹配的正六边形凹槽 [Claim 6] The animal bone foreign body particle release device according to claim 5, characterized in that: the top of the screw is provided with a regular hexagonal groove that matches with a general orthopedic hexagonal screwdriver
[权利要求 7] 根据权利要求 1至 6任意一项所述的动物骨内异物颗粒释放装置， 其特 征在于： 所述外筒的外壁为粗糙面。
[Claim 7] The animal bone foreign body particle release device according to any one of claims 1 to 6, characterized in that: the outer wall of the outer cylinder is a rough surface.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910289575.2A CN109925087A (en) | 2019-04-11 | 2019-04-11 | Foreign particles release device in a kind of Animal Bone |
| CN201910289575.2 | 2019-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2020207296A1 true WO2020207296A1 (en) | 2020-10-15 |
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| PCT/CN2020/082448 WO2020207296A1 (en) | 2019-04-11 | 2020-03-31 | Apparatus for releasing animal intraosseous foreign particle |
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| CN (1) | CN109925087A (en) |
| WO (1) | WO2020207296A1 (en) |
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| CN109925087A (en) * | 2019-04-11 | 2019-06-25 | 中南大学湘雅医院 | Foreign particles release device in a kind of Animal Bone |
| CN114190993B (en) * | 2021-12-10 | 2023-07-14 | 中南大学 | Quick sampling device is used after animal oral cavity is planted |
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