WO2020207296A1 - Appareil pour libérer des particules étrangères intra-osseuses d'animal - Google Patents

Appareil pour libérer des particules étrangères intra-osseuses d'animal Download PDF

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Publication number
WO2020207296A1
WO2020207296A1 PCT/CN2020/082448 CN2020082448W WO2020207296A1 WO 2020207296 A1 WO2020207296 A1 WO 2020207296A1 CN 2020082448 W CN2020082448 W CN 2020082448W WO 2020207296 A1 WO2020207296 A1 WO 2020207296A1
Authority
WO
WIPO (PCT)
Prior art keywords
outer cylinder
particles
foreign body
cavity
opening
Prior art date
Application number
PCT/CN2020/082448
Other languages
English (en)
Chinese (zh)
Inventor
谢杰
胡懿郃
刘东昊
李辉
杨俊骁
陈樑
陈鹏
Original Assignee
中南大学湘雅医院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201910289575.2A external-priority patent/CN109925087B/zh
Application filed by 中南大学湘雅医院 filed Critical 中南大学湘雅医院
Publication of WO2020207296A1 publication Critical patent/WO2020207296A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00—Surgical instruments for veterinary use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals

Definitions

  • the present invention relates to a device for releasing foreign body particles in animal bones.
  • Prosthesis aseptic loosening refers to the aseptic inflammation induced by various micron particles (including metal particles, polyethylene particles, ceramic particles, etc.) that appear around the prosthesis after artificial joint replacement surgery and produced by the wear of the prosthesis This in turn induces osteolysis around the prosthesis and causes the prosthesis to loosen, which is the main long-term complication after artificial joint replacement surgery, which seriously affects the life of the artificial joint and the long-term quality of life of the patient.
  • a release device for foreign body particles in animal bones comprising an outer cylinder with an opening at one end and a cavity communicating with the opening in the middle, and inducing particles formed from at least one component of an artificial joint are provided in the cavity
  • the cylinder wall of the outer cylinder is provided with a plurality of release holes communicating with the cavity and having a diameter not less than the inducing particles.
  • the opening of the outer cylinder is sealed by a sealing member.
  • the inducing particles in the cavity can release the inducing particles into the bone tissue around the device through the release hole, thereby rapidly and stably inducing aseptic inflammation, thereby inducing osteolysis, and greatly accelerating the sterility of the prosthesis The process of loosening mechanism research and drug treatment research.
  • the cylinder wall of the outer cylinder is evenly covered with the release holes.
  • the induced particles are metal micron particles, polyethylene micron particles, ceramic micron particles, or the like.
  • the seal is a screw, and an internal thread matching the screw is provided in the opening of the outer cylinder, and the screw rotates on the outer cylinder.
  • the top of the screw is provided with a regular hexagonal groove that matches with a general orthopedic hexagonal screwdriver.
  • the outer wall of the outer cylinder is a rough surface. Thereby increasing the friction after implantation and facilitating the fixation between the animal bone tissue and the cylinder wall.
  • the device can be implanted into the joints or bones of experimental animals, and the induced particles are released around the device during the movement of the experimental animals through the release holes on the cylinder wall, thereby quickly and stably Induces aseptic inflammation, which in turn induces osteolysis, and becomes an animal model of aseptic loosening of the prosthesis in a few weeks.
  • This provides a rapid prototyping carrier for studying the mechanism of aseptic loosening of the prosthesis and subsequent medical treatment, which greatly accelerates The process of research on prosthesis aseptic loosening mechanism and drug treatment research.
  • FIG. 1 is an external view of the present invention.
  • FIG. 2 is a cross-sectional view of the present invention.
  • FIG. 3 is a schematic diagram of the structure of the screw of the present invention.
  • a device for releasing foreign body particles in animal bones includes an outer cylinder 2.
  • One end of the outer cylinder 2 is open, the other end is closed, and a cavity 21 communicating with the opening is provided in the middle.
  • the cavity 21 is provided with inducing particles for inducing aseptic inflammation
  • the barrel wall of the outer cylinder 2 is provided with a plurality of release holes 22 communicating with the cavity and having a diameter not less than the inducing particles.
  • the induced particles are metal micron particles, polyethylene micron particles or ceramic micron particles, etc.
  • the opening of the outer cylinder 2 is sealed by a seal.
  • the seal is a screw 1, which is used as The cover seals the opening of the outer cylinder 2.
  • the outer cylinder opening is provided with an internal thread 11 matching the screw 1.
  • the screw 1 rotates on the outer cylinder 2, and the cylinder wall of the outer cylinder 2
  • the release holes 22 are evenly covered, and the outer wall of the outer cylinder is a rough surface. This increases the friction after implantation and facilitates the fixation between the animal tissue and the cylinder wall.
  • the top of the screw 1 is provided with a regular hexagonal groove that matches with a general orthopedic hexagonal screwdriver.
  • the outer cylinder 2 is implanted in the above-mentioned hole. Since the diameter of the hole is slightly smaller than the diameter of the outer cylinder 2, the outer cylinder 2 can be fastened in the hole by a press-fitting manner. Then pour loosening-inducing particles (such as metal micron particles, polyethylene micron particles or ceramic micron particles, etc.) into the cavity 22 of the outer cylinder 2, and tighten the screw 1. Reposition the patella and close the incision layer by layer. Routine postoperative care: wound disinfection, antibiotics to prevent infection, etc. After the operation, the experimental animals moved freely. The loosening-inducing particles can be released around the outer tube 2 to induce aseptic inflammation and then osteolysis. A few weeks later, a prosthetic aseptic loosening animal model will be formed.
  • loosening-inducing particles such as metal micron particles, polyethylene micron particles or ceramic micron particles, etc.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un appareil pour libérer une particule étrangère intra-osseuse d'animal, comprenant un cylindre externe (2) ayant une extrémité ouverte et disposé au milieu avec une cavité (21) en communication avec l'ouverture. Une particule inductrice formée par au moins un composant dans une articulation artificielle est disposée dans la cavité (21). Une pluralité de trous de libération (22) en communication avec la cavité (21) et ayant un diamètre non inférieur à celui de la particule inductrice est disposé sur la paroi du cylindre externe (2). L'ouverture du cylindre externe (2) est scellée par un élément d'étanchéité. Le présent appareil peut être utilisé pour la préparation et la recherche de base d'un modèle animal de déscelement aseptique prothétique et présente les caractéristiques de rapidité, de stabilité et de répétabilité élevées.
PCT/CN2020/082448 2019-04-11 2020-03-31 Appareil pour libérer des particules étrangères intra-osseuses d'animal WO2020207296A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910289575.2 2019-04-11
CN201910289575.2A CN109925087B (zh) 2019-04-11 一种动物骨内异物颗粒释放装置

Publications (1)

Publication Number Publication Date
WO2020207296A1 true WO2020207296A1 (fr) 2020-10-15

Family

ID=66989763

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2020/082448 WO2020207296A1 (fr) 2019-04-11 2020-03-31 Appareil pour libérer des particules étrangères intra-osseuses d'animal

Country Status (1)

Country Link
WO (1) WO2020207296A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1463755A (zh) * 2002-06-06 2003-12-31 北京市创伤骨科研究所 一种用于骨组织转化生长因子载体的制备方法
US20060004370A1 (en) * 1998-10-27 2006-01-05 The G.W. Bagby Ii Family Trust Llc Apparatus and method for preparing a spinal implant surgical site for receiving a spinal fusion implant
CN202859389U (zh) * 2012-11-05 2013-04-10 上海浦卫医疗器械厂有限公司 一种脊柱嵌件
CN108742923A (zh) * 2018-03-23 2018-11-06 云南省第人民医院 一种骨质疏松性骨折疾病动物模型的构建方法和应用
CN109925087A (zh) * 2019-04-11 2019-06-25 中南大学湘雅医院 一种动物骨内异物颗粒释放装置
CN210009169U (zh) * 2019-04-11 2020-02-04 中南大学湘雅医院 一种动物骨内异物颗粒释放装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004370A1 (en) * 1998-10-27 2006-01-05 The G.W. Bagby Ii Family Trust Llc Apparatus and method for preparing a spinal implant surgical site for receiving a spinal fusion implant
CN1463755A (zh) * 2002-06-06 2003-12-31 北京市创伤骨科研究所 一种用于骨组织转化生长因子载体的制备方法
CN202859389U (zh) * 2012-11-05 2013-04-10 上海浦卫医疗器械厂有限公司 一种脊柱嵌件
CN108742923A (zh) * 2018-03-23 2018-11-06 云南省第人民医院 一种骨质疏松性骨折疾病动物模型的构建方法和应用
CN109925087A (zh) * 2019-04-11 2019-06-25 中南大学湘雅医院 一种动物骨内异物颗粒释放装置
CN210009169U (zh) * 2019-04-11 2020-02-04 中南大学湘雅医院 一种动物骨内异物颗粒释放装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
邓智彬 (DENG, ZHIBIN), 磨损颗粒致假体周围骨溶解量效关系及防治措施的实验研究 (EXPERIMENTAL STUDY OF THE DOES-EFFECT RELATIONS AND PREVENTION MEASURES ON THE OSTEOLYSIS AROUND IMITATIVE PROSTHESIS RESULTED FROM WEAR PARTICLES), 18 December 2009 (2009-12-18), DOI: 20200602161954Y *

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