CN210009169U - Foreign matter granule release in animal bone - Google Patents
Foreign matter granule release in animal bone Download PDFInfo
- Publication number
- CN210009169U CN210009169U CN201920486227.XU CN201920486227U CN210009169U CN 210009169 U CN210009169 U CN 210009169U CN 201920486227 U CN201920486227 U CN 201920486227U CN 210009169 U CN210009169 U CN 210009169U
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- CN
- China
- Prior art keywords
- particles
- opening
- animal bone
- cavity
- animal
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
- 241001465754 Metazoa Species 0.000 title claims abstract description 19
- 210000000988 bone and bone Anatomy 0.000 title claims description 16
- 239000008187 granular material Substances 0.000 title abstract description 6
- 238000007789 sealing Methods 0.000 claims abstract description 7
- 239000002245 particle Substances 0.000 claims description 40
- 230000001939 inductive effect Effects 0.000 claims description 12
- 239000004698 Polyethylene Substances 0.000 claims description 5
- 239000000919 ceramic Substances 0.000 claims description 5
- -1 polyethylene Polymers 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 4
- 230000000399 orthopedic effect Effects 0.000 claims description 3
- 238000010171 animal model Methods 0.000 abstract description 7
- 235000017166 Bambusa arundinacea Nutrition 0.000 abstract 1
- 235000017491 Bambusa tulda Nutrition 0.000 abstract 1
- 241001330002 Bambuseae Species 0.000 abstract 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 abstract 1
- 239000011425 bamboo Substances 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 208000003076 Osteolysis Diseases 0.000 description 3
- 208000029791 lytic metastatic bone lesion Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000004417 patella Anatomy 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000036487 Arthropathies Diseases 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000037099 Prosthesis Failure Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000281 joint capsule Anatomy 0.000 description 1
- 230000008407 joint function Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Images
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- Prostheses (AREA)
Abstract
The utility model provides an animal endosseous foreign matter granule release, includes that one end opening, middle part are equipped with the urceolus with the cavity of opening intercommunication, be equipped with the induced granule that is formed by at least one composition in the artificial joint in the cavity, laid a plurality ofly on the section of thick bamboo wall of urceolus with the cavity intercommunication, and the diameter is not less than the release hole of induced granule, the opening of urceolus passes through the sealing member and seals, and this device can be used to the not hard up animal model preparation of false body aseptic nature and basic research, has characteristics quick, stable, that repeatability is high.
Description
Technical Field
The utility model relates to a foreign matter granule release in animal bone.
Background
Patients suffering from joint pain and/or joint dysfunction due to osteoarticular system disease, trauma, or both, generally undergo artificial joint replacement to improve or even restore joint function and relieve pain. However, some patients after artificial joint replacement have aseptic loosening of artificial joint prosthesis and pain during artificial joint movement. The aseptic loosening of the prosthesis refers to the fact that various micron-sized particles (including metal particles, polyethylene particles, ceramic particles and the like) generated around the prosthesis after the artificial joint replacement operation and generated by abrasion of the prosthesis are induced to generate aseptic inflammation, so that the prosthesis loosening caused by osteolysis around the prosthesis is induced, the aseptic loosening of the prosthesis is a main long-term complication after the artificial joint replacement operation, the service life of the artificial joint and the long-term life quality of a patient are seriously affected, the existing patient with the aseptic loosening of the prosthesis has to undergo revision surgery to obtain the joint movement function again, but the treatment cost of the treatment method is high, and the operation difficulty is high. In order to further research the relevant mechanism of the aseptic loosening of the prosthesis and try to intervene in the early loosening stage so as to delay/avoid the acceptance of revision surgery and treat the aseptic loosening of the prosthesis, preliminary research and animal experiments need to be carried out in an animal body, but because the aseptic loosening of the prosthesis needs to occur for a long time, how to simulate the aseptic loosening of the prosthesis quickly, stably and repeatedly is a problem to be solved urgently.
SUMMERY OF THE UTILITY MODEL
The utility model provides a quick, stable, repeatable animal bone foreign body particle release device for simulating the aseptic loosening of prosthesis, which aims at the deficiency of the prior art.
The purpose of the utility model is realized by adopting the following technical scheme:
a release device for foreign particles in animal bones comprises an outer barrel, wherein one end of the outer barrel is provided with an opening, the middle of the outer barrel is provided with a cavity communicated with the opening, the cavity is internally provided with induced particles formed by at least one component in an artificial joint, the barrel wall of the outer barrel is provided with a plurality of release holes which are communicated with the cavity and have diameters not smaller than the induced particles, and the opening of the outer barrel is sealed by a sealing element.
Furthermore, the wall of the outer cylinder is uniformly distributed with the release holes.
Further, the inducing particles are metal micron-sized particles, polyethylene micron-sized particles or ceramic micron-sized particles and the like.
Further, the sealing element is a screw, an inner thread matched with the screw is arranged on the inner wall of the opening of the outer barrel, and the screw rotates on the outer barrel.
Furthermore, the top of the screw is provided with a regular hexagon groove matched with the universal hexagon screwdriver for orthopedics.
Further, the outer wall of the outer cylinder is a rough surface. Thereby increasing the friction force after implantation and facilitating the fixation between the animal bone tissue and the wall of the cylinder.
By adopting the structure, the device can be implanted into joints or bones of experimental animals, and the inducing particles are released to the periphery of the device through the releasing holes on the cylinder wall in the moving process of the experimental animals, so that aseptic inflammation is quickly and stably induced, osteolysis is induced, and the aseptic loosening animal model of the prosthesis is formed after weeks.
Drawings
Fig. 1 is an external view of the present invention.
Fig. 2 is a cross-sectional view of the present invention.
Fig. 3 is a structural schematic of the screw of the present invention.
In the figure: 1. screw, 11, thread, 2, outer cylinder, 21, cavity, 22, release hole.
Detailed Description
The following describes an embodiment of a device for releasing foreign particles in animal bones in detail with reference to the accompanying drawings and specific examples.
As shown in fig. 1 to 3, a device for releasing foreign particles in animal bones comprises an outer cylinder 2 having an opening at one end, a cavity 21 communicating with the opening at the middle part, and a closed end, wherein an inducing particle for inducing aseptic inflammation is arranged in the cavity 21, a plurality of releasing holes 22 communicating with the cavity and having a diameter not smaller than that of the inducing particle are distributed on the cylinder wall of the outer cylinder 2, the inducing particle is a metal micron-sized particle, a polyethylene micron-sized particle, or a ceramic micron-sized particle, and the like, the opening of the outer cylinder 2 is sealed by a sealing member, in this embodiment, the sealing member is a screw 1, an inner wall of the opening of the outer cylinder is provided with an internal thread 11 matching with the screw 1, the screw 1 rotates on the outer cylinder 2, the releasing holes 22 are uniformly distributed on the cylinder wall of the outer cylinder 2, and the outer wall of the outer cylinder. Thereby increasing the friction force after implantation and facilitating the fixation between the animal tissue and the wall of the cylinder. The top of the screw 1 is provided with a regular hexagon groove matched with the universal hexagon screwdriver for orthopedics.
When in use: take the aseptic loosening model of knee joint prosthesis as an example. After anesthetizing, shaving, disinfecting, and draping experimental animals (e.g., mice, rabbits, dogs, etc.), the median skin of the knee is incised, soft tissue and muscle are separated, and the joint capsule is exposed and incised. The patella is dislocated, and a hole with the diameter slightly smaller than that of the outer cylinder 2 and the depth equal to the length of the whole device is drilled in the joint surface loading area.
The outer cylinder 2 is implanted into the hole. Since the diameter of the hole is slightly smaller than the diameter of the outer cylinder 2, the outer cylinder 2 can be fastened in the hole in a press-fit manner. Then, loosening inducing particles (such as metal micron-sized particles, polyethylene micron-sized particles or ceramic micron-sized particles) are poured into the cavity 22 of the outer cylinder 2, and the screw 1 is screwed down. The patella is repositioned and the incision is closed layer by layer. And (3) postoperative routine care: wound disinfection, antibiotic prevention of infection, etc. The experimental animal can move freely after operation. The loosening inducing particles can be released to the periphery of the outer cylinder 2 to induce aseptic inflammation and further induce osteolysis, and the aseptic loosening animal model of the prosthesis can be formed after a plurality of weeks.
The foregoing is a preferred embodiment of the present invention, but it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (7)
1. A foreign body particle release device in animal bones is characterized in that: the outer cylinder comprises an opening at one end, a cavity communicated with the opening is formed in the middle of the outer cylinder, inducing particles formed by at least one component in the artificial joint are arranged in the cavity, a plurality of releasing holes which are communicated with the cavity and have the diameter not smaller than that of the inducing particles are distributed in the wall of the outer cylinder, and the opening of the outer cylinder is sealed through a sealing element.
2. The device for releasing foreign particles in animal bone according to claim 1, wherein: the wall of the outer barrel is evenly distributed with the release holes.
3. The device for releasing foreign particles in animal bone according to claim 1, wherein: the inducing particles are all micron-sized particles.
4. The device for releasing foreign particles in animal bone according to claim 3, wherein: the inducing particles are metal micron-sized particles, polyethylene micron-sized particles or ceramic micron-sized particles and the like.
5. The device for releasing foreign particles in animal bone according to claim 1, wherein: the sealing element is a screw, the inner wall of the opening of the outer barrel is provided with an internal thread matched with the screw, and the screw rotates on the outer barrel.
6. The device for releasing foreign particles in animal bone according to claim 5, wherein: the top of the screw is provided with a regular hexagon groove matched with the orthopedic universal hexagon screwdriver.
7. The device for releasing foreign particles in animal bone according to any one of claims 1 to 6, wherein: the outer wall of the outer barrel is a rough surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920486227.XU CN210009169U (en) | 2019-04-11 | 2019-04-11 | Foreign matter granule release in animal bone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920486227.XU CN210009169U (en) | 2019-04-11 | 2019-04-11 | Foreign matter granule release in animal bone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210009169U true CN210009169U (en) | 2020-02-04 |
Family
ID=69314898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920486227.XU Withdrawn - After Issue CN210009169U (en) | 2019-04-11 | 2019-04-11 | Foreign matter granule release in animal bone |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210009169U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925087A (en) * | 2019-04-11 | 2019-06-25 | 中南大学湘雅医院 | Foreign particles release device in a kind of Animal Bone |
| CN109925087B (en) * | 2019-04-11 | 2024-05-31 | 中南大学湘雅医院 | Foreign matter particle release device in animal bone |
-
2019
- 2019-04-11 CN CN201920486227.XU patent/CN210009169U/en not_active Withdrawn - After Issue
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925087A (en) * | 2019-04-11 | 2019-06-25 | 中南大学湘雅医院 | Foreign particles release device in a kind of Animal Bone |
| WO2020207296A1 (en) * | 2019-04-11 | 2020-10-15 | 中南大学湘雅医院 | Apparatus for releasing animal intraosseous foreign particle |
| CN109925087B (en) * | 2019-04-11 | 2024-05-31 | 中南大学湘雅医院 | Foreign matter particle release device in animal bone |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20200204 Effective date of abandoning: 20240531 |
|
| AV01 | Patent right actively abandoned |
Granted publication date: 20200204 Effective date of abandoning: 20240531 |