WO2020200048A1 - 一种液路系统及其控制方法 - Google Patents

一种液路系统及其控制方法 Download PDF

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Publication number
WO2020200048A1
WO2020200048A1 PCT/CN2020/081461 CN2020081461W WO2020200048A1 WO 2020200048 A1 WO2020200048 A1 WO 2020200048A1 CN 2020081461 W CN2020081461 W CN 2020081461W WO 2020200048 A1 WO2020200048 A1 WO 2020200048A1
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WIPO (PCT)
Prior art keywords
suction
blood
liquid path
reagent
path system
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PCT/CN2020/081461
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English (en)
French (fr)
Inventor
肖健
胡喜
陈杰年
王涛
姜峰
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赫安仕科技（苏州）有限公司
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Priority to EP20783522.4A priority Critical patent/EP3943934A4/en
Publication of WO2020200048A1 publication Critical patent/WO2020200048A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood

Definitions

  • the invention relates to a thrombus elasticity chart instrument, in particular to a liquid path system of the thrombus elasticity chart instrument and a control method thereof.
  • Thromboelastometer is a medical device used to detect whether blood can coagulate normally. It is generally necessary to test the patient's blood coagulation data through the thromboelastometer before performing the operation, and determine the patient's blood coagulation based on the detected blood coagulation data Whether the process is normal, the patient can be operated on only when the blood can clot normally. If the blood clotting process is abnormal, the patient's blood will not be able to clot normally during the operation, resulting in difficulty in hemostasis, which may endanger the patient's life.
  • the physical characteristics of blood clot detection are based on the following principle: a special static cylindrical blood cup that contains blood, rotates at a low speed at an angle of 4.75, and detects the movement of the blood sample through a detection rod immersed in the blood sample. After the fibrin platelet complex adheres the cup and the detection rod, the rotational force generated by the rotation of the cup can be transmitted to the detection rod in the blood sample.
  • the strength of the fibrin platelet complex can affect the amplitude of the movement of the detection rod, so that a strong blood clot can synchronize the movement of the needle with the movement of the cup. Therefore, the movement amplitude of the measuring rod is directly related to the strength of the formed blood clot.
  • the purpose of the present invention is to overcome the defects of the prior art and provide a liquid circuit system and a control method thereof for realizing automatic addition of blood and reagents.
  • a liquid path system including a blood sample liquid path system and a reagent liquid path system
  • the blood sample liquid path system including a blood suction component, a first suction control component and a suction
  • the first suction control element is connected with the blood suction element to control the suction and release of blood by the blood suction element
  • the suction element cleaning device includes the first suction control element Connected first liquid path valve, the first liquid path valve is switched to communicate with the water source and the gas source
  • the reagent liquid path system includes at least one reagent suction part and a second suction part connected with the reagent suction part Control parts.
  • the blood sample fluid path system further includes a suction member outer wall cleaning device
  • the suction member outer wall cleaning device includes a suction member cleaning tank connected with a water source, and the blood suction member extends into the suction member.
  • a water source inlet connected to a water source is opened on the side wall of the suction part cleaning pool, and the water source inlet is located above the blood sample on the outer wall of the blood suction part.
  • the suction element cleaning device further includes a one-way valve, and two ends of the one-way valve are respectively communicated with the first suction control element and the first liquid path valve.
  • the suction cleaning device further includes a first diaphragm pump connected to the one-way valve and the first liquid path valve.
  • the first suction control member is a first plunger pump
  • the first liquid path valve is a three-way liquid path valve
  • a second diaphragm pump is connected between the water source inlet and the water source.
  • the blood sample liquid path system further includes a sewage collection device, the sewage collection device includes a third diaphragm pump and a sewage bucket connected to the third diaphragm pump, and the third diaphragm pump is cleaned with the suction member.
  • the sewage outlet at the bottom of the tank is connected.
  • the present invention discloses another technical solution: a liquid path control method, including a blood sample liquid path control method and a reagent liquid path control method, wherein:
  • the blood sample liquid path control method includes:
  • the first suction control part controls the blood suction part to suck blood from the blood sample and release it into the detection cup;
  • the first suction control part is closed, the first liquid path valve is opened, and the water source is controlled to enter the blood suction part for cleaning;
  • the reagent liquid path control method includes:
  • the second suction control component controls the reagent suction component to suck the reagent from the reagent corresponding to the reagent suction component and release it into the detection cup.
  • the blood sample fluid path control method further includes:
  • the A4 specifically includes: extending the blood suction element into the suction element cleaning tank, and the water source enters the suction element cleaning tank through the water source inlet to clean the outer wall of the blood suction element.
  • the blood sample fluid path control method further includes:
  • A5. Collect the sewage after cleaning the blood suction part.
  • the A5 specifically includes: sewage under the control of the third diaphragm pump enters the sewage bucket from the sewage outlet at the bottom of the suction unit cleaning tank for collection.
  • the present invention realizes the complete automation of blood and reagent addition in the blood coagulation data detection process by designing the liquid path system, instead of manual operation, reduces the labor intensity of detecting blood coagulation data, and reduces the production cost; and the liquid path system Reliable operation, high repetition rate, low error rate, and improved detection accuracy.
  • Figure 1 is a structural block diagram of the fluid system of the present invention
  • FIGS. 2 and 5 to 10 are structural block diagrams of different embodiments of the blood sample liquid path system of the present invention.
  • Figure 3 is a schematic diagram of the structure of the blood suction member of the present invention.
  • Figure 4 is a schematic view of the structure of the first/second suction control member of the present invention.
  • Figure 11 is a structural block diagram of the reagent liquid path system of the present invention.
  • Figure 12 is a schematic structural view of the reagent suction member of the present invention.
  • FIG. 13 and 14 are schematic flowcharts of different embodiments of the liquid path control method of the present invention.
  • FIG. 15 is a schematic diagram of a specific structure of the blood sample liquid path system corresponding to the embodiment of FIG. 10;
  • Fig. 16 is a schematic diagram of a specific structure of the reagent liquid path system corresponding to the embodiment of Fig. 11.
  • Liquid path system 2. Blood sample liquid path system, 21, blood suction part, 22, first suction control part, 23, suction part cleaning device, 231, first liquid path valve, 232, one-way valve , 233, the first diaphragm pump, 24, the outer wall cleaning device of the suction part, 241, the suction part cleaning tank, 2411, the water source inlet, 2412, the sewage outlet, 242, the second diaphragm pump, 25, the sewage collection device, 251, The third diaphragm pump, 252, the sewage tank, 3. The reagent liquid system, 31, the reagent suction part, 32, the second suction control part, 33, the second liquid valve, 4, the water tank, 5, the air source, 6. Integrated rod, 61. Connecting port, 7. Adapter.
  • the liquid path system and its control method disclosed in the present invention realize the automation of the blood and reagent addition process in the blood coagulation data detection.
  • a fluid path system 1 disclosed in an embodiment of the present invention includes an independent blood sample fluid path system 2 and a reagent fluid path system 3, wherein the blood sample fluid path system 2 is used to detect blood coagulation data.
  • the reagent liquid path system 3 is used to realize the actual automatic addition process in the blood coagulation data detection.
  • the blood sample liquid path system 2 includes a blood suction member 21, a first suction control member 22, and a suction member cleaning device 23, wherein the blood suction member 21 is used for
  • the blood is sucked, as shown in Fig. 3, which is a hollow suction needle as a whole.
  • Fig. 3 is a hollow suction needle as a whole.
  • the first suction control member 22 is in communication with the blood suction member 21, and is specifically connected to the upper end of the blood suction member 21 through a hose (such as a PVC tube). During implementation, as shown in FIG. 4, the first suction control member 22 A plunger pump can be used. Its working principle is that when the first suction control part 22 is working, it controls the formation of negative pressure in the blood suction part 21, and sucks the blood in the blood sample tube into the blood suction part 21. When closed, the blood sucked by the blood sucking member 21 is controlled to be released into the detection cup (not shown).
  • the suction piece cleaning device 23 is connected to the blood suction piece 21 and is used to thoroughly clean the inner wall of the blood suction piece 21 after the blood suction piece 21 releases blood into the detection cup.
  • the suction member cleaning device 23 includes a first liquid path valve 231, which communicates with the blood suction member 21 through the first suction control member 22 , And the first liquid path valve 231 is also in communication with a gas source and a water source.
  • the first liquid path valve 231 can be a control valve with at least three ports, such as a two-position three-way liquid path valve, and of course, a four-way valve, a five-way valve, and the like.
  • the water source 4 can be clean water, and the clean water is stored in a water tank, that is, the three-way liquid valve is connected to the water tank; the air source 5 can be air.
  • the first liquid path valve 231 and the water source 4 can also be connected through an adapter 7.
  • the three-way liquid path valve 231 controls the interface connected to the water tank 4 to be in a connected state, and the interface connected to the air source 5 is in a closed state. Then, under the control of the first suction control member 22, pumping from the water tank 4 The suction water source enters the blood suction part 21 through each connecting hose, and cleans the inner wall of the blood suction part 21. After the cleaning is completed, in order to remove the remaining cleaning liquid on the inner wall of the blood suction part 21, the three-way liquid The road valve 231 controls the interface connected to the water tank 4 to be in a closed state, and the interface connected to the air source 5 is in a connected state.
  • the air source 5 is sucked through each connecting hose Into the blood suction member 21, the cleaning liquid remaining on the inner wall of the blood suction member 21 is blown off.
  • the deep cleaning and drying of the blood suction member 21 is realized, so that it can suck other types of blood samples, and avoid cross-contamination between different blood samples.
  • the first suction control member 22 in order to prevent blood from flowing into the water tank 4 or the air source 5 through the first suction control member 22, or to avoid the backflow of the water source 4 and the air source 5, the first suction control member 22 A one-way valve 232 can be added between the first liquid path valve 231 and the first liquid path valve 231, which restricts the water source 4 and the air source 5 from being input into the blood suction member 21 in one direction, and the reverse direction is not connected.
  • the one-way valve 232 is closed when the first suction control part 22 is opened to control the blood suction part 21 to suck blood, and is opened when the suction part cleaning device 23 is working.
  • a first diaphragm pump 233 is connected between the one-way valve 232 and the first liquid path valve 231 to cooperate with the first suction control member 22 to realize the water source 4 and the air source. 5 suction control.
  • the blood sample liquid path system 2 of the embodiment of the present invention further includes a suction piece outer wall cleaning device 24 , which specifically includes a suction part cleaning tank 241 and a second diaphragm pump 242, wherein the blood suction part 21 extends into the suction part cleaning tank 241, and the suction part cleaning tank 241 is connected to the above-mentioned through the second diaphragm pump 242
  • the water source ie, the water tank 4
  • the second diaphragm pump 242 is connected to the suction unit cleaning pool 241 and the water tank 4, and is used to control the suction of the water in the water tank 4 into the suction unit cleaning pool 241, and the suction unit
  • the outer wall of the blood suction member 21 in the washing tank 241 is washed.
  • a water source inlet 2411 is opened on the side wall of the suction cleaning pool 241 close to the top of itself, and the water source inlet 2411 is in communication with the second diaphragm pump 242.
  • the embodiment of the present invention sets the height of the water source inlet 2411 in the suction member cleaning pool 241 to be higher than The height of the blood sample on the outer wall of the blood suction part 21 in the suction part cleaning pool 241, that is, above the blood sample on the outer wall of the blood suction part 21, so as to ensure that the water entering the blood suction part 21 can completely cover and wash the blood.
  • the blood sample on the outer wall of the aspirating member 21 makes the blood sample on the outer wall of the blood aspirating member 21 clean thoroughly.
  • the blood sample liquid path system of the embodiment of the present invention may further include a sewage collection device 25, which is connected to the suction unit cleaning tank 241, and is used to clean the suction unit The sewage generated after the cleaning of the outer wall of the suction member 23 and the cleaning device 24 is collected and discharged.
  • a sewage collection device 25 which is connected to the suction unit cleaning tank 241, and is used to clean the suction unit The sewage generated after the cleaning of the outer wall of the suction member 23 and the cleaning device 24 is collected and discharged.
  • the sewage collection device 25 includes a third diaphragm pump 251 and a sewage bucket 252 connected to the third diaphragm pump 251, wherein the suction member cleans the tank 241
  • a sewage outlet 2412 is provided on the upper part, specifically at the bottom thereof; the third diaphragm pump 251 communicates with the sewage outlet 2412 and the sewage bucket 252 for controlling the discharge of cleaning sewage generated in the suction cleaning tank 241 to the sewage bucket 252.
  • the reagent liquid path system 3 specifically includes at least one reagent suction member 31 and a second suction control member 32 communicating with the reagent suction member 31, wherein the reagent pump
  • the suction member 31 is used to suck the reagents required for the test.
  • the reagent suction member 31 is generally provided in multiple during implementation, and each reagent suction member 31 sucks one kind of reagent.
  • Seven reagent suction parts 31 are provided, that is, 7 kinds of reagents are correspondingly suctioned.
  • the number of reagent suction parts 31 is not limited and can be set according to the needs of the reagents.
  • Each reagent suction member 31 is also a hollow suction needle as a whole, and its lower end penetrates into the reagent tube (not shown) when the reagent is sucked.
  • the seven reagent suction parts 31 are all connected to an integrated rod 6, and a communication port 61 is provided on the integrated rod 6 corresponding to each reagent suction part 31.
  • the second suction control member 32 is connected to the communication port 61 on the integrated rod 6 as required to realize the connection with the reagent suction member 31 corresponding to the communication port 61.
  • the second suction control member 32 may be a plunger pump. Because each reagent suction member 31 sucks a corresponding detection reagent, there is no cross-contamination between each other, so the reagent liquid path system here may not be provided with a corresponding cleaning device.
  • the embodiment of the present invention also discloses a liquid path control method, including a blood sample liquid path control method and a reagent liquid path control method, wherein:
  • the blood sample fluid path control method specifically includes:
  • the first suction control part 22 controls the blood suction part 21 to suck blood from the blood sample and release it into the detection cup.
  • the first suction control member 22 when the first suction control member 22 is working, it controls the formation of negative pressure in the blood suction member 21, sucks the blood in the blood sample tube into the blood suction member 21, and when it is closed, controls the blood suction The blood sucked by the piece 21 is released into the detection cup.
  • the first liquid path valve 231 is opened, and under the control of the first suction control member 22, the water source is controlled to enter the blood suction member 21 for cleaning.
  • the one-way valve 232 is opened, and the first liquid path valve 231 controls the interface connected to the water tank 4 to open.
  • the first suction control member 22 and the first diaphragm pump 233 water is drawn from the water tank 4 and sent into Go inside the blood suction member 21 and clean the inner wall of the blood suction member 21.
  • the one-way valve 232 is still open, and the first liquid path valve 231 controls the interface connected to the air source 5 to open, and the first suction control member 22 and the first diaphragm
  • the extraction air source 5 is sent into the blood suction part 21, and the water source remaining in the blood suction part 21 is blown off.
  • step A3 it further includes A4 to clean the outer wall of the blood suction member 21.
  • the second diaphragm pump 242 controls the water in the water tank 4 to be pumped into the suction unit washing tank 241, and cleans the outer wall of the blood suction unit 21 in the suction unit washing tank 241.
  • step A4 it further includes A5 to collect the sewage after washing the blood suction member 21.
  • the sewage enters the sewage bucket 252 from the sewage outlet 2412 at the bottom of the suction cleaning tank 241 under the control of the third diaphragm pump 251 and is collected.
  • the reagent liquid path control method includes:
  • the second suction control component 32 controls the reagent suction component 31 to suck the reagent from the reagent corresponding to the reagent suction component 31 and release it into the detection cup.
  • the second suction control component 32 sucks the reagent in the corresponding reagent suction component 31 as needed, and controls the reagent suction component 31 to release the sucked reagent into the detection cup.

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Abstract

一种液路系统（1）及其控制方法，系统（1）包括血样液路系统（2）和试剂液路系统（3），血样液路系统（2）包括血液抽吸件（21）、第一抽吸控制件（22）和抽吸件清洗装置（23），第一抽吸控制件（22）与血液抽吸件（21）相连通，控制血液抽吸件（21）对血液的抽吸和释放；抽吸件清洗装置（23）包括与第一抽吸控制件（22）相连的第一液路阀（231），第一液路阀（231）能切换为与水源（4）相连通或与气源（5）相连通；试剂液路系统（3）包括至少一个试剂抽吸件（31）和与试剂抽吸件（31）相连通的第二抽吸控制件（32）。该系统（1）能够实现对血凝数据检测中血液和试剂添加过程的自动化。

Description

一种液路系统及其控制方法 技术领域
本发明涉及一种血栓弹力图仪，尤其是涉及一种血栓弹力图仪的液路系统及其控制方法。
背景技术
血栓弹力仪是一种用于检测血液是否能够正常凝结的医疗器械，在进行手术前一般都需要通过血栓弹力仪对患者的血凝数据进行检测，根据检测出的血凝数据判断患者的血液凝结过程是否正常，只有在血液能够正常凝结的情况下才能对患者进行手术，如果血液凝结过程存在异常，手术过程中患者的血液将无法正常凝结，导致止血困难，很可能危及患者的生命。
检测血凝块的物理特性基于以下原理：一特制静止盛有血液的圆柱形盛血杯，以4.75的角度低速旋转，通过一根浸泡在血样中的检测杆来检测血样的运动。纤维蛋白血小板复合物将杯和检测杆粘在一起后，杯旋转所产生的旋转力能传递至血样中的检测杆。纤维蛋白血小板复合物的强度能影响检测杆运动的幅度，以致强硬的血凝块能使针的运动与杯的运动同步进行。因此，测量杆的运动幅度与已形成的血凝块的强度有直接关系。当血凝块回缩或溶解时，检测杆与血凝块的联结解除，杯的运动不再传递给检测杆，检测杆的旋转则由传感器检测。
目前的血栓弹力图仪，在对血凝数据进行检测时，需要通过手动的方式向检测杯中添加血液和试剂，这需要耗费检测人员大量的时间，造成检测血凝数据的劳动强度较大，检测效率低；且手动添加对人工的技术水平依赖较大，影响检测精度。
发明内容
本发明的目的在于克服现有技术的缺陷，提供一种实现血液和试剂自动添加的液路系统及其控制方法。
为实现上述目的，本发明提出如下技术方案：一种液路系统，包括血样液路系统和试剂液路系统，所述血样液路系统包括血液抽吸件、第一抽吸控制件和抽吸件清洗装置，所述第一抽吸控制件与血液抽吸件相连通，控制血液抽吸件对血液的抽吸和释放；所述抽吸件清洗装置包括与所述第一抽吸控制件相连的第一液路阀，所述第一液路阀切换与水源和气源相连通；所述试剂液路系统包括至少一个试剂抽吸件和与试剂抽吸件相连通的第二抽吸控制件。
优选地，所述血样液路系统还包括抽吸件外壁清洗装置，所述抽吸件外壁清洗装置包括与水源相连通的抽吸件清洗池，所述血液抽吸件伸入到所述抽吸件清洗池内，所述抽吸件清洗池的侧壁开设一与水源相连通的水源入口，所述水源入口位于血液抽吸件外壁上血样的上方。
优选地，所述抽吸件清洗装置还包括单向阀，所述单向阀的两端分别与第一抽吸控制件和第一液路阀相连通。
优选地，所述抽吸件清洗装置还包括接通于所述单向阀和第一液路阀的第一隔膜泵。
优选地，所述第一抽吸控制件为第一柱塞泵，所述第一液路阀为三通液路阀。
优选地，所述水源入口和水源之间还接通一第二隔膜泵。
优选地，所述血样液路系统还包括污水收集装置，所述污水收集装置包括第三隔膜泵和与第三隔膜泵相连通的污水桶，所述第三隔膜泵与设置于抽吸件清洗池底部的污水出口相连通。
本发明揭示了另外一种技术方案：一种液路控制方法，包括血样液路控制方法和试剂液路控制方法，其中，
所述血样液路控制方法包括：
A1，第一抽吸控制件控制血液抽吸件从血样中抽吸血液并释放到检测杯中；
A2，第一抽吸控制件关闭，第一液路阀打开，控制水源进入到血液抽吸件内进行清洗；
A3，清洗后再切换控制气源吹入到血液抽吸件内，吹除掉血液抽吸件内残留的水源；
所述试剂液路控制方法包括：
B1，第二抽吸控制件控制试剂抽吸件从与试剂抽吸件相对应的试剂中抽吸试剂并释放到检测杯中。
优选地，所述血样液路控制方法还包括：
A4，对血液抽吸件的外壁进行清洗。
优选地，所述A4具体包括：将血液抽吸件伸入到抽吸件清洗池内，水源经水源入口进入到抽吸件清洗池内对血液抽吸件的外壁进行清洗。
优选地，所述血样液路控制方法还包括：
A5，对血液抽吸件清洗后的污水进行收集。
优选地，所述A5具体包括：污水在第三隔膜泵的控制下从抽吸件清洗池底部的污水出口进入到污水桶内收集起来。
本发明的有益效果是：
1、本发明通过设计液路系统，实现血凝数据检测过程中血液和试剂添加的完全自动化，代替了人工操作的方法，降低了检测血凝数据的劳动强度，降低生产成本；且液路系统运行可靠，重复率高，出错率低，提高检测精度。
2、采用水源和气源配合对血样液路进行清洗，使得血液抽吸件内彻底清洗干净，且清洗血液抽吸件内壁的同时，对血液抽吸件外壁也进行清洗，进一步提高血液抽吸件的洁净度，避免不同血样的交叉污染。
3、对清洗后的污水进行回收，节能环保。
附图说明
图1是本发明液路系统的结构框图；
图2、图5～图10均是本发明血样液路系统不同实施例的结构框图；
图3是本发明血液抽吸件的结构示意图；
图4是本发明第一/第二抽吸控制件的结构示意图；
图11是本发明试剂液路系统的结构框图；
图12是本发明试剂抽吸件的结构示意图；
图13、图14是本发明液路控制方法不同实施例的流程示意图；
图15是与图10实施例相对应的血样液路系统的具体结构示意图；
图16是与图11实施例相对应的试剂液路系统的具体结构示意图。
附图标记：
1、液路系统，2、血样液路系统，21、血液抽吸件，22、第一抽吸控制件，23、抽吸件清洗装置，231、第一液路阀，232、单向阀，233、第一隔膜泵，24、抽吸件外壁清洗装置，241、抽吸件清洗池，2411、水源入口，2412、污水出口，242、第二隔膜泵，25、污水收集装置，251、第三隔膜泵，252、污水桶，3、试剂液路系统，31、试剂抽吸件，32、第二抽吸控制件，33、第二液路阀，4、水箱，5、气源，6、集成杆，61、连通口，7、转接件。
具体实施方式
下面将结合本发明的附图，对本发明实施例的技术方案进行清楚、完整的描述。
本发明所揭示的一种液路系统及其控制方法，实现对血凝数据检测中血液和试剂添加过程的自动化。
如图1所示，本发明实施例所揭示的一种液路系统1，包括独立的血样液路系统2和试剂液路系统3，其中，血样液路系统2用于实现血凝数据检测中血液的自动添加过程，试剂液路系统3则用于实现血凝数据检测中实际的自动添加过程。
具体地，本实施例中，结合图2所示，血样液路系统2包括血液抽吸件21、第一抽吸控制件22和抽吸件清洗装置23，其中，血液抽吸件21用于吸取血液，如图3所示，其整体为一中空的吸针状，其在吸取血液时，下端深入到血样试管(图未示)中。
第一抽吸控制件22与血液抽吸件21相连通，具体通过软管(如PVC管)连接血液抽吸件21的上端，实施时，如图4所示，第一抽吸控制件22可采用柱塞泵，其工作原理为，第一抽吸控制件22工作时，控制血液抽吸件21内形成负压，将血样试管中的血液抽吸进入到血液抽吸件21内，在关闭时，则控制血液抽吸件21抽吸的血液释放到检测杯(图未示)中。
抽吸件清洗装置23与血液抽吸件21相连，用于在血液抽吸件21向检测杯中释放完血液后，对血液抽吸件21的内壁进行彻底清洁。具体地，如图5所示，本实施例中，抽吸件清洗装置23包括第一液路阀231，第一液路阀231通过第一抽吸控制件22与血液抽吸件21相连通，且第一液路阀231还与气源和水源相连通。实施时，第一液路阀231可采用至少有三个接口的控制阀，如两位三通液路阀，当然也可为四通阀、五通阀等。三通液路阀的其中一接口与第一抽吸控制件22相连通，另外两个接口分别连通气源5和水源4。实施时，水源4可为清水，清水存储于一水箱内，也就是说三通液路阀与水箱相连；气源5可为空气。另外，所述第一液路阀231和水源4之间还可以通过一转接件7连接。
清洗时，首先三通液路阀231控制与水箱4相连的接口处于连通状态，与气源5相连的接口则处于关闭状态，之后在第一抽吸控制件22的控制下，从水箱4抽吸上水源经过各个连通软管进入到血液抽吸件21内，对血液抽 吸件21的内壁进行清洗，清洗结束后，为了去除掉血液抽吸件21内壁上残存的清洗液，三通液路阀231控制与水箱4相连的接口处于关闭状态，与气源5相连的接口则处于连通状态，之后在第一抽吸控制件22的控制下，将气源5经过各个连通软管抽吸到血液抽吸件21内，将血液抽吸件21的内壁残存的清洗液吹除掉。从而实现了对血液抽吸件21的深度清洁和吹干，使其可以抽吸其他类型的血样，避免不同血样之间的交叉污染。
优选地，如图6所示，为了避免血液经第一抽吸控制件22流到水箱4或气源5中，或者为了避免水源4和气源5的回流，在第一抽吸控制件22和第一液路阀231之间还可增设一单向阀232，即限制水源4和气源5只能单向输入到血液抽吸件21内，反向不连通。该单向阀232在第一抽吸控制件22开启控制血液抽吸件21抽吸血液时关闭，在抽吸件清洗装置23工作时开启。
更优选地，如图6所示，在单向阀232和第一液路阀231之间再接一第一隔膜泵233，用于与第一抽吸控制件22配合实现水源4和气源5的抽吸控制。
进一步地，为了在清洗血液抽吸件的内壁的同时，对血液抽吸件的外壁进行清洗，如图7所示，本发明实施例的血样液路系统2还包括抽吸件外壁清洗装置24，其具体包括抽吸件清洗池241和第二隔膜泵242，其中，血液抽吸件21伸入到该抽吸件清洗池241内，抽吸件清洗池241通过第二隔膜泵242与上述水源(即水箱4)相连通，即第二隔膜泵242连通抽吸件清洗池241和水箱4，用于控制将水箱4内的水抽吸到抽吸件清洗池241内，对抽吸件清洗池241内的血液抽吸件21的外壁进行清洗。
具体地，如图8所示，在抽吸件清洗池241的靠近其自身顶端的侧壁上开设一水源入口2411，该水源入口2411与第二隔膜泵242相连通。优选地，为了保证血液抽吸件21外壁在抽吸血液时沾染的血液均能被清洗干净，本发明实施例将上述水源入口2411在抽吸件清洗池241内的高度，设 置高于伸入到抽吸件清洗池241内的血液抽吸件21外壁上血样的高度，即位于血液抽吸件21外壁上血样的上方，这样能够保证进入血液抽吸件21的水能够完全覆盖清洗到血液抽吸件21外壁上的血样，使得血液抽吸件21外壁上的血样清洗彻底。
进一步地，如图9所示，本发明实施例的血样液路系统还可以包括污水收集装置25，该污水收集装置25与上述抽吸件清洗池241相连通，用于将抽吸件清洗装置23和抽吸件外壁清洗装置24清洗后产生的污水进行收集并排放。具体地，结合图10和图15所示，本实施例中，污水收集装置25包括第三隔膜泵251和与第三隔膜泵251相连通的污水桶252，其中，抽吸件清洗池241的上设置有污水出口2412，具体设置于其底部；第三隔膜泵251连通污水出口2412和污水桶252，用于控制将抽吸件清洗池241内产生的清洗污水排放收集到污水桶252内。
本实施例中，结合图11和图16所示，试剂液路系统3具体包括至少一个试剂抽吸件31和与试剂抽吸件31相连通的第二抽吸控制件32，其中，试剂抽吸件31用于吸取检测所需的试剂，试剂抽吸件31实施时一般设置为多个，每个试剂抽吸件31对应抽吸一种试剂，本实施例中，结合图12所示，设置7个试剂抽吸件31，即对应抽吸7种试剂，当然，试剂抽吸件31的设置数量不限，可以根据试剂需要进行设置。取哪种试剂可以由一第二液路阀33实现，第二液路阀33设置于试剂抽吸件31和第二抽吸控制件32之间。每个试剂抽吸件31整体也为一中空的吸针状，其在吸取试剂时，下端深入到试剂管(图未示)中。且7个试剂抽吸件31均连通到一集成杆6上，集成杆6上对应每个试剂抽吸件31的位置处设置一连通口61。
第二抽吸控制件32根据需要选择与上述集成杆6上的连通口61相连，实现与连通口61对应的试剂抽吸件31相连，第二抽吸控制件32可采用柱塞泵。因为每个试剂抽吸件31对应吸取一种检测试剂，彼此之间不会形成交叉污染，所以这里的试剂液路系统可以不设置相应的清洗装置。
基于上述液路系统，如图13所示，本发明实施例还揭示了一种液路控制方法，包括血样液路控制方法和试剂液路控制方法，其中，
血样液路控制方法具体包括：
A1，第一抽吸控制件22控制血液抽吸件21从血样中抽吸血液并释放到检测杯中。
具体地，第一抽吸控制件22工作时，控制血液抽吸件21内形成负压，将血样试管中的血液抽吸进入到血液抽吸件21内，在关闭时，则控制血液抽吸件21抽吸的血液释放到检测杯中。
A2，第一液路阀231打开，在第一抽吸控制件22的控制下，控制水源进入到血液抽吸件21内进行清洗。
具体地，单向阀232打开，第一液路阀231控制与水箱4相连的接口打开，在第一抽吸控制件22和第一隔膜泵233的配合工作下，从水箱4抽取水送入到血液抽吸件21内部，对血液抽吸件21的内壁进行清洗。
A3，清洗后再切换控制气源5吹入到血液抽吸件21内，吹除掉血液抽吸件21内残留的水源。
具体地，在血液抽吸件21的内壁清洗完成后，单向阀232仍然打开，第一液路阀231控制与气源5相连的接口打开，在第一抽吸控制件22和第一隔膜泵233的配合工作下，抽取气源5送入到血液抽吸件21内部，吹除掉血液抽吸件21内残留的水源。
如图14所示，优选地，在步骤A3后，还包括A4，对血液抽吸件21的外壁进行清洗。具体地，第二隔膜泵242控制将水箱4内的水抽吸到抽吸件清洗池241内，对抽吸件清洗池241内的血液抽吸件21的外壁进行清洗。
如图14所示，更优选地，在步骤A4后，还包括A5，对血液抽吸件21清洗后的污水进行收集。具体地，污水在第三隔膜泵251的控制下从抽吸件清洗池241底部的污水出口2412进入到污水桶252内收集起来。
所述试剂液路控制方法包括：
B1，第二抽吸控制件32控制试剂抽吸件31从与试剂抽吸件31相对应的试剂中抽吸试剂并释放到检测杯中。
具体地，第二抽吸控制件32根据需要吸取对应试剂抽吸件31中的试剂，并控制试剂抽吸件31将吸取的试剂释放到检测杯中。
本发明的技术内容及技术特征已揭示如上，然而熟悉本领域的技术人员仍可能基于本发明的教示及揭示而作种种不背离本发明精神的替换及修饰，因此，本发明保护范围应不限于实施例所揭示的内容，而应包括各种不背离本发明的替换及修饰，并为本专利申请权利要求所涵盖。

Claims (10)

  1. 一种液路系统，其特征在于，包括血样液路系统和试剂液路系统，所述血样液路系统包括血液抽吸件、第一抽吸控制件和抽吸件清洗装置，所述第一抽吸控制件与血液抽吸件相连通，控制血液抽吸件对血液的抽吸和释放；所述抽吸件清洗装置包括与所述第一抽吸控制件相连的第一液路阀，所述第一液路阀切换与水源和气源相连通；所述试剂液路系统包括至少一个试剂抽吸件和与试剂抽吸件相连通的第二抽吸控制件。
  2. 根据权利要求1所述的液路系统，其特征在于，所述血样液路系统还包括抽吸件外壁清洗装置，所述抽吸件外壁清洗装置包括与水源相连通的抽吸件清洗池，所述血液抽吸件伸入到所述抽吸件清洗池内，所述抽吸件清洗池的侧壁开设一与水源相连通的水源入口，所述水源入口位于血液抽吸件外壁上血样的上方。
  3. 根据权利要求1所述的液路系统，其特征在于，所述抽吸件清洗装置还包括单向阀，所述单向阀的两端分别与第一抽吸控制件和第一液路阀相连通。
  4. 根据权利要求3所述的液路系统，其特征在于，所述抽吸件清洗装置还包括接通于所述单向阀和第一液路阀的第一隔膜泵。
  5. 根据权利要求1所述的液路系统，其特征在于，所述第一抽吸控制件为第一柱塞泵，所述第一液路阀为三通液路阀。
  6. 根据权利要求2所述的液路系统，其特征在于，所述水源入口和水源之间还接通一第二隔膜泵。
  7. 根据权利要求2所述的液路系统，其特征在于，所述血样液路系统还包括污水收集装置，所述污水收集装置包括第三隔膜泵和与第三隔膜泵相连通的污水桶，所述第三隔膜泵与设置于抽吸件清洗池底部的污水出口相连通。
  8. 一种基于权利要求1～7任意一项所述的液路系统的液路控制方法，其特征在于，所述方法包括血样液路控制方法和试剂液路控制方法，其中，
    所述血样液路控制方法包括：
    A1，第一抽吸控制件控制血液抽吸件从血样中抽吸血液并释放到检测杯中；
    A2，第一抽吸控制件关闭，第一液路阀打开，控制水源进入到血液抽吸件内进行清洗；
    A3，清洗后再切换控制气源吹入到血液抽吸件内，吹除掉血液抽吸件内残留的水源；
    所述试剂液路控制方法包括：
    B1，第二抽吸控制件控制试剂抽吸件从与试剂抽吸件相对应的试剂中抽吸试剂并释放到检测杯中。
  9. 根据权利要求8所述的液路控制方法，其特征在于，所述血样液路控制方法还包括：
    A4，对血液抽吸件的外壁进行清洗。
  10. 根据权利要求8所述的液路控制方法，其特征在于，所述血样液路控制方法还包括：
    A5，对血液抽吸件清洗后的污水进行收集。
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