WO2020195352A1 - Instrument de dosage et système de dosage d'une solution médicamenteuse - Google Patents

Instrument de dosage et système de dosage d'une solution médicamenteuse Download PDF

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Publication number
WO2020195352A1
WO2020195352A1 PCT/JP2020/006292 JP2020006292W WO2020195352A1 WO 2020195352 A1 WO2020195352 A1 WO 2020195352A1 JP 2020006292 W JP2020006292 W JP 2020006292W WO 2020195352 A1 WO2020195352 A1 WO 2020195352A1
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WIPO (PCT)
Prior art keywords
cannula
drug solution
administration device
tip
thin
Prior art date
Application number
PCT/JP2020/006292
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English (en)
Japanese (ja)
Inventor
みなみ 前川
昭宏 高橋
陽一郎 岩瀬
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テルモ株式会社
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Publication of WO2020195352A1 publication Critical patent/WO2020195352A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body

Definitions

  • the present invention relates to an administration device and a drug solution administration system having the administration device and the drug solution administration device.
  • a syringe pump type drug solution administration device that administers a drug solution filled in a drug solution container into a living body by a pressing action of a pusher is known.
  • an administration device provided with a cannula (catheter) and connectable to the drug solution administration device may be used (see Patent Document 1).
  • the administration device described in Patent Document 1 has a puncture portion (cannula housing) that holds the cannula so as to protrude from the contact surface (bottom surface) that is brought into contact with the body surface of the user.
  • a lumen through which the introduction needle can be inserted is formed in the cannula, and the cannula is punctured into the living body with the introduction needle protruding from the tip. After puncturing the body with the cannula, the introduction needle is removed from the lumen of the cannula.
  • the drug solution administration device can easily administer the drug solution into the living body through the tip opening of the cannula.
  • the opening at the tip of the cannula may be pressed against the living body tissue to block it. If the opening at the tip of the cannula is occluded, the drug solution administration device cannot administer the drug solution in vivo.
  • the present invention has been made in view of the above problems, and is an administration device capable of administering a drug solution even when the tip opening of the cannula is occluded, and a drug solution administration having the administration device and the drug solution administration device.
  • the purpose is to provide a system.
  • the administration device is an administration device that can be connected to a drug solution administration device including a drug solution container filled with a drug solution, and is connectable to the drug solution administration device and is connected to the drug solution administration device.
  • a connection portion formed with a lumen that can communicate with the lumen of the drug solution container, a cannula having a tip opening and being punctured by a living body, a contact surface that contacts the body surface of the living body, and the cannula.
  • the puncture portion includes a cannula holding portion that holds the cannula so that the tip protrudes from the contact surface, and a communication passage that communicates with the lumen of the cannula and the lumen of the connection portion.
  • the cannula is formed in a part of the circumferential direction of the cannula on the proximal end side of the tip opening and on the distal end side of the contact surface, and has a wall thickness smaller than that of other parts excluding the tip of the cannula. It has a thin-walled portion that cleaves when it receives a pressure higher than the set pressure.
  • the drug solution administration system includes the drug solution administration device, the drug solution container, a housing for holding the drug solution container, and a pusher for pushing the drug solution in the drug solution container into the cannula. And have.
  • the drug solution can be administered even when the tip opening of the cannula is occluded.
  • FIG. 5 is an enlarged side view showing a cannula provided in the administration device of the drug solution administration system shown in FIG. 1.
  • FIG. 5 is an enlarged axial sectional view showing a cannula provided in the administration device shown in FIG. 1.
  • It is an enlarged view of the area surrounded by the broken line 6 of FIG.
  • It is an end view along the line 7-7 of FIG.
  • It is a schematic diagram which shows the state which the drug solution is administered into the living body through the tip opening of the cannula provided in the administration instrument shown in FIG.
  • FIG. 1 It is a schematic diagram which shows the state in which the thin-walled portion of the cannula provided in the administration device shown in FIG. 1 is cleaved, and the drug solution is administered into the living body from the cleaved thin-walled portion. It is a side view which shows the cannula which concerns on the modification. It is an end view along the line 10-10 of FIG.
  • FIGS. 1 to 8B are diagrams provided for explaining the drug solution administration system 10, the drug solution administration device 100, and the administration device 200 according to the embodiment of the present invention.
  • the arrow X attached to each figure indicates the "longitudinal direction" of the drug solution administration device 100 and the administration device 200, and the arrow Y indicates the “width direction (depth direction)” of the drug solution administration device 100 and the administration device 200.
  • Z indicates the "height direction (axial direction of the cannula 220)" of the drug solution administration device 100 and the administration device 200.
  • the cross-sectional view shown in FIG. 3 is a vertical cross-sectional view (cross-sectional view of the XZ cross section) of the drug solution administration device 100 and the administration instrument 200.
  • "a to b" indicating a range means “a or more and b or less”.
  • the drug solution administration system 10 is used to administer the drug solution in vivo. As shown in FIG. 1, the drug solution administration system 10 includes a drug solution administration device 100 and an administration device 200.
  • the puncture portion 230 of the drug solution administration device 100 and the administration device 200 is attached to the body surface H of the user.
  • the part of the body of the user to which the drug solution administration device 100 and the puncture portion 230 are attached is not particularly limited, and is, for example, the abdomen, the deltoid muscle, or the thigh.
  • the chemical solution (not shown) filled in the chemical solution container 110 included in the chemical solution administration device 100 is pressed by the pusher 130 for a relatively long time (for example, about several minutes to several hours). ) Can be continuously administered in vivo.
  • the drug solution administration system 10 may intermittently administer the drug solution into the living body.
  • the chemical solution administration device 100 includes a chemical solution container 110 filled with a chemical solution, a housing 120 for holding the chemical solution container 110, and a pusher 130 for pushing the chemical solution in the chemical solution container 110 into a cannula 220 described later. ,have.
  • the chemical solution container 110 is composed of a cylinder having a cavity 111 filled with the chemical solution.
  • the tip of the pusher 130 is inserted into the cavity 111 of the chemical container 110.
  • a gasket 131 is arranged at the tip of the pusher 130.
  • the gasket 131 can be made of, for example, a resin material such as a rubber material or an elastomer.
  • the outer peripheral portion of the gasket 131 is in close contact with the inner peripheral surface of the chemical liquid container 110 in a liquid-tight manner, thereby sealing the base end side of the gasket 131 in a liquid-tight manner.
  • the chemical solution container 110 is composed of a so-called prefilled chemical solution container. Therefore, the chemical solution is pre-filled in the cavity 111 of the chemical solution container 110.
  • the drug solution include protein preparations, narcotic analgesics, diuretics and the like.
  • a sealing member 112 for preventing the chemical liquid from leaking is arranged at the tip opening (discharge port) of the chemical liquid container 110.
  • the tip opening of the chemical solution container 110 is arranged so as to project to the outside of the housing 120.
  • the pusher 130 is configured to be movable forward with respect to the chemical solution container 110 toward the tip end side (left side in FIG. 3) of the chemical solution container 110 by a forward mechanism (not shown).
  • the pusher 130 pushes the chemical solution out of the cavity 111 of the chemical solution container 110 into the cannula 220 by advancing with respect to the chemical solution container 110.
  • a battery that supplies electric power required for each operation of the chemical administration device 100, a substrate on which a control unit that controls a motor is attached, a drive mechanism for driving a forward mechanism, and the like (all not shown). Is housed.
  • the drug solution administration device 100 is configured as a patch type to be used by being attached to the body surface (skin) H of the user.
  • a sheet-shaped attachment portion (not shown) that can be attached to the body surface is provided on the contact surface (bottom surface) 121 of the housing 120 of the chemical solution administration device 100.
  • a peelable protective sheet is attached to the attachment surface of the attachment portion.
  • the administration device 200 is configured to be connectable to the drug solution administration device 100. As shown in FIG. 3, the administration device 200 has a connection portion 210, a cannula 220, a puncture portion 230, and a puncture assisting tool 240. Hereinafter, each part of the administration device 200 will be described.
  • the connecting portion 210 is configured to be connectable to the drug solution administration device 100.
  • the connecting portion 210 is formed with a lumen 210a that can communicate with the lumen 111 of the chemical solution container 110 in a state of being connected to the chemical solution administration device 100.
  • the connecting portion 210 has a connector 211 that can be connected to the vicinity of the tip end portion of the chemical solution container 110, and a tube 212 that connects the connector 211 and the puncture portion 230.
  • the connector 211 is a connecting needle tube 214 having a mounting portion 213 that is externally fitted near the tip of the chemical solution container 110 projecting to the outside of the housing 120 and a needle tip capable of penetrating the sealing member 112. And a communication portion 215 that is connected to the mounting portion 213 and holds the connecting needle tube 214 and the tube 212.
  • the communication portion 215 is formed with a lumen 215a that communicates the lumen 214a of the connecting needle tube 214 and the lumen 212c of the tube 212.
  • One end 212a of the tube 212 (hereinafter referred to as the first end 212a) is held by the communication portion 215.
  • the other end portion 212b of the tube 212 (hereinafter referred to as the second end portion 212b) is held by the puncture portion 230 in a state of being inserted into the communication passage 233 of the puncture portion 230 described later.
  • the connector 211 is connected to the drug solution administration device 100 via the mounting portion 213, and the needle tip of the connecting needle tube 214 seals the drug solution administration device 100.
  • the lumen 210a of the connecting portion 210 is composed of the lumen 214a of the connecting needle tube 214, the lumen 215a of the communicating portion 215, and the lumen 212c of the tube 212.
  • the configuration of the connecting portion is not particularly limited as long as it is configured to be connectable to the drug solution administration device and a lumen that can communicate with the lumen of the drug solution container is formed while being connected to the drug solution administration device.
  • the puncture portion 230 is arranged at the lower end of the puncture portion 230, and the contact surface 231 (bottom surface) that contacts the surface of the living body and the tip (lower end) of the cannula 220 that is arranged above the contact surface 231 project from the contact surface 231.
  • it has a cannula holding portion 232 for holding the cannula 220, and a communication passage 233 communicating with the lumen 220b of the cannula 220 and the lumen 210a of the connecting portion 210.
  • the direction of protrusion of the cannula 220 from the contact surface 231 is substantially perpendicular to the contact surface 231. Therefore, the axes of the cannula 220 intersect substantially perpendicular to the contact surface 231.
  • the administration device 200 is configured as a patch type to be used by being attached to the body surface H of the user, similarly to the drug solution administration device 100.
  • the contact surface 231 is provided with a sheet-shaped attachment portion (not shown) that can be attached to the body surface.
  • a peelable protective sheet (not shown) is attached to the attachment surface of the attachment portion.
  • the communication passage 233 includes a first flow path 233a extending from the base end of the cannula 220 along the axis of the cannula 220, and a second flow path 233b that communicates the first flow path 233a with the second end portion 212b of the tube 212. ,have.
  • a sealing member 234 is arranged to prevent the chemical liquid from leaking from the base end of the communication passage 233 after the introduction needle 241 described later is removed from the communication passage 233. ing.
  • the puncture aid 240 is attached to the puncture portion 230 when the drug solution is sent to the user.
  • the puncture aid 240 holds the introduction needle (inner needle) 241.
  • the introduction needle 241 can be composed of, for example, a metal needle.
  • the puncture aid 240 can be prepared, for example, in a state of being attached to the puncture portion 230 in advance before using the drug solution administration system 10.
  • the introduction needle 241 is inserted into the communication passage 233 of the puncture portion 230 and the lumen 220b of the cannula 220 with the puncture aid 240 attached to the puncture portion 230. Further, in this state, the tip of the introduction needle 241 protrudes from the tip of the cannula 220.
  • the puncture aid 240 is removed from the puncture portion 230 after the cannula 220 is punctured into the living body.
  • the introduction needle 241 is removed from the lumen 220b of the cannula 220 when the puncture aid 240 is removed from the puncture portion 230.
  • the lumen 220b of the cannula 220 communicates with the communication passage 233 of the puncture portion 230.
  • the lumen 220b of the cannula 220 communicates with the lumen 210a of the connecting portion 210 via the communication passage 233.
  • the pusher 130 of the drug solution administration device 100 advances in the drug solution container 110, so that the drug solution filled in the cavity 111 of the drug solution container 110 is connected to the cavity 210a of the connection portion 210 and the puncture portion 230.
  • the liquid is sent to the lumen 220b of the cannula 220 via the passage 233.
  • the cannula 220 is formed with a lumen 220b that axially penetrates the cannula 220.
  • the cannula 220 is punctured into a living body with the introduction needle 241 inserted in the lumen 220b.
  • the cannula 220 may be configured so that the living body is punctured only by the cannula 220.
  • Cannula 220 is punctured on the body surface H of the user.
  • the side inserted into the living body in the axial direction of the cannula is referred to as the distal end side, and the opposite side thereof is referred to as the proximal end side.
  • a certain range in the axial direction from the tip (leading edge) is referred to as a tip portion, and a constant range in the axial direction from the proximal end (most proximal end) is referred to as a proximal end portion.
  • the opening on the tip side of the cannula is referred to as a tip opening.
  • the cannula 220 is connected to the distal end portion 221 whose outer diameter gradually decreases from the proximal end side to the distal end side and the proximal end of the distal end portion 221 and is connected to the proximal end side to the distal end side.
  • a first outer diameter constant portion 222 having a substantially constant outer diameter toward the surface, and a tapered portion 223 connected to the proximal end of the first outer diameter constant portion 222 and gradually decreasing in outer diameter from the proximal end side toward the distal end side.
  • a second outer diameter constant portion 224 which is connected to the proximal end of the tapered portion 223 and has a substantially constant outer diameter from the proximal end side to the distal end side.
  • the cannula 220 further has a proximal end portion 225 that is connected to the proximal end of the second outer diameter constant portion 224 and whose outer diameter gradually increases from the distal end side to the proximal end side.
  • the base end portion 225 is formed so that not only the outer diameter but also the inner diameter gradually increases from the tip end side toward the base end side. Therefore, the cannula 220 can efficiently flow the chemical solution from the communication passage 233 to the base end portion.
  • the cannula 220 has a thin portion 250 having a wall thickness smaller than that of other portions of the cannula 220 except the tip portion 221.
  • the thin-walled portion 250 is formed in a part of the circumferential direction ⁇ of the cannula 220 on the proximal end side of the tip opening 220a and on the distal end side of the contact surface 231.
  • the thin portion 250 is cleaved when it receives a pressure higher than a set pressure.
  • the "set pressure" means the internal pressure of the cannula 220 when the tip opening 220a is closed.
  • the set pressure is not particularly limited, but is, for example, 32 MPa to 360 MPa.
  • the thin portion 250 has an inner recess 251 formed in a part of the circumferential direction ⁇ of the inner peripheral surface of the cannula 220.
  • the inner recess 251 is formed on the inner peripheral surface of the tapered portion 223.
  • the mold clamping unit includes a mold in which a cavity corresponding to the outer shape of the cannula 220 is formed, and a core having an outer shape corresponding to the inner cavity 220b of the cannula 220 (both are not shown). That is, the core is formed with a convex portion having an outer diameter corresponding to the inner concave portion 251, and there is a step between the tip of the convex portion and the portion of the core that is axially adjacent to the tip of the convex portion.
  • the injection unit heats and melts the resin material and pours it into the mold of the molding unit.
  • the mold is then cooled and the cured molded product (cannula 220) is removed from the mold and core.
  • the core can be easily removed from the base end side of the molded product.
  • the inner concave portion 251 can be formed when the cannula 220 is injection-molded, it is not necessary to further perform processing for forming the inner concave portion 251 after the injection molding of the cannula 220.
  • the distance L1 (see FIG. 5) from the base end of the thin portion 250 (inner recess 251) to the contact surface 231 is not particularly limited and can be appropriately set according to the puncture site of the living body.
  • the distance L1 from the base end of the thin portion 250 to the contact surface 231 can be, for example, 2.0 mm to 10.5 mm.
  • the cannula 220 may puncture the blood vessel.
  • the axial dimension L2 (see FIGS. 5 and 6) of the thin portion 250 is not particularly limited, but can be, for example, 0.2 mm to 2.0 mm.
  • the dimension L3 (see FIG. 7) in the direction orthogonal to the axial direction of the thin portion 250 is not particularly limited, but may be, for example, 0.2 mm to 0.4 mm.
  • the minimum wall thickness T1 (see FIG. 6) of the thin portion 250 is not particularly limited, but can be set to, for example, 0.01 mm to 0.04 mm. By configuring the cannula 220 in this way, the thin-walled portion 250 can be easily cleaved when the tip opening 220a is closed.
  • the ratio of the minimum wall thickness T1 of the thin wall portion 250 to the wall thickness T2 of the adjacent portion adjacent to the thin wall portion 250 of the cannula 220 is not particularly limited, but can be set to, for example, 0.05 to 0.40.
  • the thin-walled portion 250 can be easily cleaved when the tip opening 220a is closed.
  • adjacent part means the part which is adjacent to the thin part in the cannula in the axial direction or the circumferential direction.
  • the adjacent portion means a portion of the tapered portion 223 excluding the thin portion 250 (inner recess 251).
  • the material constituting the cannula 220 is not particularly limited as long as it is biocompatible and breaks when subjected to a set pressure, but is not particularly limited, but is polytetrafluoroethylene, tetrafluoroethylene / ethylene copolymer resin, and polyethylene. It can be formed of a known resin material such as.
  • the puncture aid 240 is attached to the puncture portion 230 of the administration device 200, and the cannula 220 is punctured into the living body with the tip of the introduction needle 241 protruding from the tip of the cannula 220. .. Then, the contact surface 231 of the puncture portion 230 is attached to the body surface of the user.
  • the puncture aid 240 is removed, and the puncture portion 230 is left on the body surface H of the user with the cannula 220 indwelled in the living body. ..
  • the pusher 130 of the drug solution administration device 100 advances in the drug solution container 110, so that the drug solution filled in the cavity 111 of the drug solution container 110 of the drug solution administration device 100 is punctured with the cavity 210a of the connection portion 210.
  • the liquid is sent to the lumen 220b of the cannula 220 via the communication passage 233 of the portion 230.
  • the introduction needle 241 protrudes from the tip of the cannula 220. Therefore, as shown in FIG. 8A, when the introduction needle 241 is removed from the lumen 220b of the cannula 220, a space S is formed between the tip of the cannula 220 and the living tissue. Therefore, the drug solution administration device 100 can easily administer the drug solution into the living body through the tip opening 220a of the cannula 220, as shown by the arrow a1 in FIG. 8A.
  • the tip surface of the cannula 220 is strongly pressed against the living body tissue, and the tip opening 220a may be blocked.
  • the puncture portion 230 is strongly pressed against the living body, the tip surface of the cannula 220 is strongly pressed against the living body, whereas the outer peripheral surface of the cannula 220 is in contact with the living body but is strongly pressed against the living body as compared with the tip surface. Not done.
  • the cannula 220 easily cleaves the thin-walled portion 250 formed on the outer peripheral surface of the cannula 220 when the tip opening 220a of the cannula 220 is closed and the internal pressure of the cannula 220 becomes equal to or higher than the set pressure. be able to. Then, the drug solution administration device 100 can administer the drug solution to the living body through the cleaved thin-walled portion 250 as shown by the arrow a2 in FIG. 8B.
  • the tip opening 220a is cannulated not only because the puncture portion 230 is strongly pressed against the living body by an external force, but also because, for example, a thrombus or the like occludes the tip opening 220a, or the user moves the body. It can also be blocked by the 220 being bent in the living body.
  • the administration device 200 is an administration device that can be connected to the drug solution administration device 100 including the drug solution container 110 filled with the drug solution.
  • the administration device 200 has a connection portion 210, a cannula 220, and a puncture portion 230.
  • the connecting portion 210 can be connected to the chemical solution administration device 100, and a lumen 210 a that can communicate with the lumen 111 of the chemical solution container 110 is formed while being connected to the chemical solution administration device 100.
  • the cannula 220 has a tip opening 220a and is punctured by a living body.
  • the puncture portion 230 is connected to a contact surface 231 that contacts the body surface H of the living body, a cannula holding portion 232 that holds the cannula 220 so that the tip of the cannula 220 protrudes from the contact surface 231, and a lumen 220b of the cannula 220. Includes a communication passage 233 communicating with the lumen 210a of the portion 210.
  • the cannula 220 has a thin portion 250.
  • the thin-walled portion 250 is formed in a part of the circumferential direction ⁇ of the cannula 220 on the proximal end side of the tip opening 220a and on the distal end side of the contact surface 231 and is smaller than other portions except the tip portion 221 of the cannula 220. It has a wall thickness and cleaves when it receives a pressure higher than the set pressure.
  • the administration device 200 when the tip opening 220a of the cannula 220 is closed, the internal pressure of the cannula 220 becomes a pressure equal to or higher than the set pressure, so that the thin portion 250 is cleaved and the thin portion 250 is cleaved through the cleaved thin portion 250.
  • the drug solution can be administered in vivo. Therefore, according to the administration device 200, the drug solution can be administered even when the tip opening 220a of the cannula 220 is occluded.
  • the thin portion 250 has an inner recess 251 formed in a part of the circumferential direction ⁇ of the inner peripheral surface of the cannula 220. Therefore, when the tip opening 220a of the cannula 220 is closed, the inner recess 251 can be cleaved and the drug solution can be administered into the living body. Further, since the inner recess 251 is formed on the inner peripheral surface of the cannula 220, the cannula 220 can be smoothly punctured into the living body.
  • the cannula 220 has a tapered portion 223 in which the outer diameter of the cannula 220 gradually decreases from the proximal end side toward the distal end side on the proximal end side of the distal end opening 220a and on the distal end side of the contact surface 231. Is formed on the inner peripheral surface of the tapered portion 223. According to such a configuration, the cannula 220 provided with the inner recess 251 can be easily formed by injection molding. Therefore, it is not necessary to further process the inner recess 251 after injection molding of the cannula 220.
  • the minimum wall thickness T1 of the thin portion 250 is 0.1 mm to 0.4 mm. According to the cannula 220 configured in this way, the thin-walled portion 250 is easily cleaved when the tip opening 220a of the cannula 220 is closed.
  • the ratio of the minimum wall thickness T1 of the thin wall portion 250 to the minimum wall thickness of the adjacent portion adjacent to the thin wall portion 250 of the cannula 220 is 0.05 to 0.40. According to the cannula 220 configured in this way, the thin-walled portion 250 is easily cleaved when the tip opening 220a of the cannula 220 is closed.
  • the set pressure is 32 MPa to 360 MPa. According to the cannula 220 configured in this way, the thin-walled portion 250 is easily cleaved when the tip opening 220a of the cannula 220 is closed.
  • the drug solution administration system 10 includes the above-mentioned administration device 200 and the drug solution administration device 100.
  • the chemical solution administration device 100 includes a chemical solution container 110, a housing 120 for holding the chemical solution container 110, and a pusher 130 for pushing the chemical solution in the chemical solution container 110 into the cannula 220.
  • the drug solution administration device 100 can administer the drug solution into the living body through the cleaved thin-walled portion 250.
  • (Modification example) 9 and 10 are diagrams showing the cannula 320 according to the modified example.
  • the cannula 320 is formed with a lumen 320b that penetrates the cannula 320 in the axial direction of the cannula 320.
  • the portion of the cannula 320 on the distal end side of the contact surface 231 may be configured to have a constant inner diameter from the proximal end side toward the distal end side.
  • the portion of the cannula 320 on the tip end side of the contact surface 231 may have a constant outer diameter from the base end side to the tip end side, except for the thin-walled portion 350 described later.
  • the outer diameter of the cannula is not particularly limited as long as the thin portion is formed.
  • the cannula 320 has a thin portion 350 having a wall thickness smaller than that of other portions.
  • the thin-walled portion 350 is formed in a part of the circumferential direction ⁇ of the cannula 320 on the proximal end side of the tip opening 320a and on the distal end side of the contact surface 231.
  • the thin portion 350 is cleaved when it receives a pressure higher than a set pressure.
  • the thin-walled portion 350 has an outer recess 351 formed in a part of the circumferential direction ⁇ of the outer peripheral surface of the cannula 320.
  • the outer recess 351 is not particularly limited, but can be formed by laser processing or the like.
  • the outer recess 351 separates from the living tissue with the cannula 320 indwelling in the living body. Therefore, when the tip opening 320a of the cannula 320 is closed, the cannula 320 can easily open the outer recess 351.
  • the thin-walled portion 350 has an outer recess 351 formed in a part of the circumferential direction ⁇ of the outer peripheral surface of the cannula 320. Therefore, when the tip opening 320a of the cannula 320 is closed, the outer recess 351 can be cleaved and the drug solution can be administered into the living body. Further, when the tip opening 320a of the cannula 320 is closed, the outer recess 351 is separated from the living tissue with the cannula 320 indwelled in the living body. Therefore, the cannula 320 can easily cleave the outer recess 351.
  • the present invention is not limited to each of the described configurations, and may be appropriately modified based on the description of the claims. It is possible.
  • each member constituting the administration device and the drug solution administration system are not particularly limited as long as the effects of the present invention are exhibited. , Can be changed and replaced at will. Further, it is also possible to appropriately add arbitrary constituent members and the like not particularly described in the specification to the administration device and the drug solution administration system.
  • the thin-walled portion may have both an inner recess and an outer recess. Further, for example, the thin-walled portion may have a plurality of inner recesses (or outer recesses) in the circumferential direction or the axial direction.
  • Chemical administration system 100 drug solution administration device, 110 chemical container, 111 Inner cavity of chemical container, 120 housing, 130 pusher, 200 administration device, 210 connection, 210a Connection cavity, 220, 320 cannula, 220a, 320a Cannula tip opening, 220b, 320b Cannula lumen 221 Cannula tip, 223 taper part, 230 puncture site, 231 contact surface, 232 Cannula holder, 233 consecutive passages, 240 Puncture aid, 241 introduction needle, 250, 350 thin part, 251 Inner recess, 351 outer recess, H body surface, T1 Minimum wall thickness of thin part, Minimum wall thickness of T2 adjacent part, ⁇ Circumferential direction.

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  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Le problème décrit par la présente invention est de fournir un instrument de dosage capable d'administrer une solution médicamenteuse même lorsqu'une ouverture de pointe d'une canule est obstruée. La solution selon l'invention porte sur un instrument de dosage (200) qui peut être relié à un dispositif de dosage d'une solution médicamenteuse (100) pourvu d'un récipient de solution médicamenteuse (110) rempli d'une solution médicamenteuse. L'instrument de dosage (200) peut être relié au dispositif de dosage d'une solution médicamenteuse et présente : une partie de liaison (210) formée d'une cavité interne (210a) qui peut communiquer avec une cavité interne (111) du récipient de solution médicamenteuse lorsqu'elle est reliée au dispositif de dosage d'une solution médicamenteuse ; une canule (220) qui présente une ouverture de pointe (220a) et qui est perforée dans un corps vivant ; et une partie de perforation (230) qui comprend une surface de contact (231) pour entrer en contact avec une surface corporelle H, une partie de retenue de canule (232) pour retenir la canule de sorte que la pointe de la canule fait saillie depuis la surface de contact, et un passage de communication (233) qui communique avec une cavité interne (220b) de la canule et la cavité interne de la partie de liaison. La canule présente une section à paroi fine (250) qui est formée dans une partie dans le sens de la circonférence θ de la canule près d'une extrémité de base lorsque l'ouverture de pointe se trouve au niveau, et est plus proche, de la pointe que ne l'est la surface de contact, et est pourvue d'une épaisseur de paroi inférieure à celle des autres parties de la canule excepté pour une partie de pointe (231), la section à paroi fine se clivant lorsqu'elle est soumise à une pression supérieure ou égale à une pression définie.
PCT/JP2020/006292 2019-03-28 2020-02-18 Instrument de dosage et système de dosage d'une solution médicamenteuse WO2020195352A1 (fr)

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JP2019-064746 2019-03-28
JP2019064746A JP2022077535A (ja) 2019-03-28 2019-03-28 投与器具、および薬液投与システム

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WO2020195352A1 true WO2020195352A1 (fr) 2020-10-01

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009273609A (ja) * 2008-05-14 2009-11-26 Nippon Sherwood Medical Industries Ltd 弁付きカテーテル
JP2015503422A (ja) * 2012-01-05 2015-02-02 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ スプリット及びサイドポートをもつカテーテル装置
WO2016157638A1 (fr) * 2015-03-27 2016-10-06 テルモ株式会社 Dispositif d'administration de médicament liquide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009273609A (ja) * 2008-05-14 2009-11-26 Nippon Sherwood Medical Industries Ltd 弁付きカテーテル
JP2015503422A (ja) * 2012-01-05 2015-02-02 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ スプリット及びサイドポートをもつカテーテル装置
WO2016157638A1 (fr) * 2015-03-27 2016-10-06 テルモ株式会社 Dispositif d'administration de médicament liquide

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