WO2020188305A1 - Pommade pour le traitement de brûlures - Google Patents

Pommade pour le traitement de brûlures Download PDF

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Publication number
WO2020188305A1
WO2020188305A1 PCT/GR2020/000017 GR2020000017W WO2020188305A1 WO 2020188305 A1 WO2020188305 A1 WO 2020188305A1 GR 2020000017 W GR2020000017 W GR 2020000017W WO 2020188305 A1 WO2020188305 A1 WO 2020188305A1
Authority
WO
WIPO (PCT)
Prior art keywords
olive oil
burns
oil
treatment
ointment
Prior art date
Application number
PCT/GR2020/000017
Other languages
English (en)
Inventor
Helen PATSIANIDI
Original Assignee
Patsianidi Helen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Patsianidi Helen filed Critical Patsianidi Helen
Priority to EP20718759.2A priority Critical patent/EP3952837A1/fr
Publication of WO2020188305A1 publication Critical patent/WO2020188305A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Definitions

  • the invention relates to an ointment for the treatment of burns and is the product of intense mixing and mild heat treatment of the following ingredients: olive oil, petroleum jelly, goose fat, sulfanilamide powder, rapeseed oil, vitamins A, D and E.
  • This ointment has the advantage of other products which are not therapeutic but preservative.
  • This treatment can mainly heal damaged skin tissues from burns of the first (1st), second (2nd) but also equally and third (3rd) degree and as well as wounds that come from the lesions.
  • the estimated third-degree burn healing beginning is from ten (10) to twenty-one (21) days, with the most common beginning of healing at fourteen (14) days.
  • the use of this ointment reduces healing in half the time compared to other methods and products, but its main feature is that it leaves no scars after healing.
  • the precondition for this to happen, however, is its application from the first day of the burn, as well as how it is applied: a sufficient amount of ointment is applied to a cotton cloth wich is sterile, applied in order to heal to the wound so that no grid (scar tissue) appears on the wound during healing. This also helps protect the wound against exogenous contaminants. Change to this fabric is done every 48 hours, and the sterile fabric is glued to the healthy areas of the skin with paper tape the other way so as to breath the skin.
  • Exemplary other similar techniques are based on patents such as RU2452475C2, CN102349920B, US3761590, which generally refer to the use of sulfanilamide and other active compounds that belong to the group of sulfonamides, such as having sulfadiazine that are antibacterial and antibiotic action, but not in powder form with specific grains, nor in combination with the use of olive oil, petroleum jelly, goose fat, rapeseed oil and vitamins A, D and E.
  • This preparation is in the form of an ointment, resulting from intense mixing and gentle heating, for a period of twenty (20) to thirty (30) minutes, and then stored in a shady and cool place at a temperature of four (4° C) to twenty-five (25 ° C) degrees Celsius and the exact method of preparation is as follows:
  • the mixing of the ingredients takes place in a double-walled container and. at a constant temperature for a period of twenty (20) to thirty (30) first minutes of the hour with a constant mixing rate.
  • a vacuum and pressure mixer or homogenizer mixer or pressure cooker assemblies are designed to provide high quality productions of pharmaceutical preparations and cosmetics, gels, toothpaste, mascara, hair care products etc.
  • the mixing temperature should remain constant throughout the mixing as deviations adversely affect the result and the optimum temperature range is from twenty (20° C) to forty (40° C) degrees Celsius, preferably from twenty-five (25° C) to thirty-five (35° C) degrees Celsius, ideally from twenty-seven (27° C) to thirty-two (32° C) degrees Celsius.
  • the rotational speed during homogenization may be from 2800 rpm to 3100 rpm, preferably from 2850 rpm to 3050 rpm, ideally from 2900 rpm to 3000 rpm.
  • the mixing sequence is as follows: first mix the first (1st) with the second (2nd) and then add the third (3rd) to the resulting mixture and then add the fifth (5th) to the resulting mixture component and then to the resulting mixture is added the fourth component (4th).
  • goose fat should be golden in color without any foreign matter and be homogeneous, with a characteristic odor of goose.
  • the goose fat treatment should be mild and have a maximum treatment temperature of eighty (80° C) degrees Celsius.
  • Sulfanilamide should be fine-grained, if it does not have the necessary granulometry characteristics, the friction component is converted to a finer powder, in particular less than thirty (30mm) microns, preferably less than twenty two (22mm), ideally the granulometry should be from sixteen microns (16mm) to twenty two microns (22mm) .
  • Olive oil is preferably 2-3% low-acid olive oil and even better Virgin Olive Oil, which is virgin olive oil, that is olive oil produced only by natural and mechanical processes, with good organoleptic characteristics, with a free acidity of not more than 2.0%, and even better Extra Virgin Olive Oil, which is virgin olive oil, produced solely by natural and mechanical processes, with a perfect aroma and taste, with a free acidity of not more than 0.8%.
  • the final moisture content of the ointment should be from 10% to 20% by weight, preferably from 12.5% to 17.5% by weight.
  • the above product after being stored in the refrigerator, takes the form of a pale yellow aqueous ointment with a characteristic odor of goose and butter.
  • the above product after its airtight packaging, remains active, in a refrigerator of four (4° C) degrees Celsius and at a temperature of up to twenty-five (25° C) degrees Celsius, in a shady and cool place for twelve (12) months.
  • the preservative used is potassium sorbate from 0.1% to 0.3% by weight, preferably from 0.1% to 0.2% by weight.
  • the ointment is suitable for burns of all three degrees, as defined below based on the depth of the injury. In addition, it is also suitable for healing of other skin lesions such as openings in the skin caused by bedtime.
  • the ointment is suitable for:

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une pommade pour le traitement de brûlures et de lésions cutanées de manière générale et est le produit d'un mélange intense et d'un traitement thermique doux des ingrédients suivants : huile d'olive, gelée de pétrole, graisse d'oie, poudre de sulfanilamide, huile de colza, vitamines A, D et E. Cette préparation se présente sous la forme d'une pommade, résultant d'un mélange intense et d'un chauffage doux, pendant les 20 à 30 premières minutes. La séquence de mélange, la granulation du principe actif, la combinaison du principe actif et des ingrédients naturels, l'utilisation de vitamines et d'huiles, le traitement thermique doux ont des effets bénéfiques et réduisent le temps de cicatrisation. Ce produit final est utilisé pour un usage externe à étaler sur la zone brûlée de la peau pour provoquer autant que possible une cicatrisation radicale indolore et rapide. Sa caractéristique principale est une absence de cicatrices visibles.
PCT/GR2020/000017 2019-03-18 2020-03-13 Pommade pour le traitement de brûlures WO2020188305A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20718759.2A EP3952837A1 (fr) 2019-03-18 2020-03-13 Pommade pour le traitement de brûlures

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR20190100123 2019-03-18
GR20190100123A GR1009789B (el) 2019-03-18 2019-03-18 Αλοιφη για τη θεραπεια εγκαυματων

Publications (1)

Publication Number Publication Date
WO2020188305A1 true WO2020188305A1 (fr) 2020-09-24

Family

ID=70285723

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GR2020/000017 WO2020188305A1 (fr) 2019-03-18 2020-03-13 Pommade pour le traitement de brûlures

Country Status (3)

Country Link
EP (1) EP3952837A1 (fr)
GR (1) GR1009789B (fr)
WO (1) WO2020188305A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3761590A (en) 1970-05-18 1973-09-25 Research Corp Silver sulfadiazine used in the treatment of burns
US20080193552A1 (en) * 1995-10-30 2008-08-14 Curacid America Corporation Topical medicament for skin injuries and disorders
CN101642575A (zh) * 2009-09-25 2010-02-10 惠连旺 软膏状药用基质
CN102349920A (zh) 2011-08-10 2012-02-15 成都第一药物研究所有限公司 一种用于创面的磺胺类药物组合物
RU2452475C2 (ru) 2010-06-17 2012-06-10 Закрытое акционерное общество "СНС-фарма" Средство для лечения ран, ожогов и инфекционно-воспалительных заболеваний кожи, придатков кожи и слизистых оболочек
CN107929098A (zh) * 2017-12-06 2018-04-20 杨益文 一种美容护肤品以及治疗烧烫伤的药物组合物
WO2019125313A1 (fr) * 2017-12-21 2019-06-27 Caliskan Muharrem Crème de traitement de brûlures et son procédé de production

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1525285A (en) * 1922-04-24 1925-02-03 Gabbola Raffaele Composition for use as a salve or ointment
GR1004321B (el) * 2002-10-02 2003-08-28 Μιραντα Βασιλειου Μιχαλακοπουλου Αλοιφη για εγκαυματα
RU2337702C2 (ru) * 2006-12-28 2008-11-10 Лидия Ибрагимовна Гайсанова Бальзам "гайсановой", обладающий ранозаживляющим, противовоспалительным и противоожоговым действием
UA97076C2 (ru) * 2011-04-22 2011-12-26 Светлана Владимировна Бабий Мазь противовоспалительная на основе сульфаниламида
US11813284B2 (en) * 2013-08-08 2023-11-14 Novan, Inc. Topical compositions and methods of using the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3761590A (en) 1970-05-18 1973-09-25 Research Corp Silver sulfadiazine used in the treatment of burns
US20080193552A1 (en) * 1995-10-30 2008-08-14 Curacid America Corporation Topical medicament for skin injuries and disorders
CN101642575A (zh) * 2009-09-25 2010-02-10 惠连旺 软膏状药用基质
RU2452475C2 (ru) 2010-06-17 2012-06-10 Закрытое акционерное общество "СНС-фарма" Средство для лечения ран, ожогов и инфекционно-воспалительных заболеваний кожи, придатков кожи и слизистых оболочек
CN102349920A (zh) 2011-08-10 2012-02-15 成都第一药物研究所有限公司 一种用于创面的磺胺类药物组合物
CN107929098A (zh) * 2017-12-06 2018-04-20 杨益文 一种美容护肤品以及治疗烧烫伤的药物组合物
WO2019125313A1 (fr) * 2017-12-21 2019-06-27 Caliskan Muharrem Crème de traitement de brûlures et son procédé de production

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LONG VALENCIA ED - COTLIAR JONATHAN ET AL: "The Evolution of Burn Therapy-Then and Now", JAMA DERMATOLOGY, AMERICAN MEDICAL ASSOCIATION, US, vol. 153, no. 2, 1 February 2017 (2017-02-01), pages 136, XP009521275, ISSN: 2168-6084, DOI: 10.1001/JAMADERMATOL.2016.0164 *

Also Published As

Publication number Publication date
GR1009789B (el) 2020-08-03
EP3952837A1 (fr) 2022-02-16

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