WO2020185041A3 - 세로토닌 수식 히알루론산을 포함하는 하이드로젤 및 이의 용도 - Google Patents

세로토닌 수식 히알루론산을 포함하는 하이드로젤 및 이의 용도 Download PDF

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Publication number
WO2020185041A3
WO2020185041A3 PCT/KR2020/003549 KR2020003549W WO2020185041A3 WO 2020185041 A3 WO2020185041 A3 WO 2020185041A3 KR 2020003549 W KR2020003549 W KR 2020003549W WO 2020185041 A3 WO2020185041 A3 WO 2020185041A3
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WIPO (PCT)
Prior art keywords
hyaluronic acid
modified hyaluronic
hydrogel including
including serotonin
serotonin
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PCT/KR2020/003549
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English (en)
French (fr)
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WO2020185041A2 (ko
Inventor
조승우
안수환
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연세대학교 산학협력단
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Application filed by 연세대학교 산학협력단 filed Critical 연세대학교 산학협력단
Priority to EP20770858.7A priority Critical patent/EP3928804A4/en
Priority to US17/438,679 priority patent/US20220143190A1/en
Priority to CN202080021249.4A priority patent/CN113574109B/zh
Publication of WO2020185041A2 publication Critical patent/WO2020185041A2/ko
Publication of WO2020185041A3 publication Critical patent/WO2020185041A3/ko

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Abstract

본 발명은 세로토닌으로 수식된 히알루론산을 포함하는 하이드로젤, 이의 용도 및 이의 제조방법에 관한 것이다.
PCT/KR2020/003549 2019-03-14 2020-03-13 세로토닌 수식 히알루론산을 포함하는 하이드로젤 및 이의 용도 WO2020185041A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP20770858.7A EP3928804A4 (en) 2019-03-14 2020-03-13 HYDROGEL COMPRISING HYALURONIC ACID MODIFIED BY MEANS OF SEROTONIN AND THEIR USE
US17/438,679 US20220143190A1 (en) 2019-03-14 2020-03-13 Hydrogel comprising hyaluronic acid modified by serotonin and uses thereof
CN202080021249.4A CN113574109B (zh) 2019-03-14 2020-03-13 包含经血清素修饰的透明质酸的水凝胶及其用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190029214A KR102308721B1 (ko) 2019-03-14 2019-03-14 세로토닌 수식 히알루론산을 포함하는 하이드로젤 및 이의 용도
KR10-2019-0029214 2019-03-14

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Publication Number Publication Date
WO2020185041A2 WO2020185041A2 (ko) 2020-09-17
WO2020185041A3 true WO2020185041A3 (ko) 2020-11-05

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US (1) US20220143190A1 (ko)
EP (1) EP3928804A4 (ko)
KR (1) KR102308721B1 (ko)
CN (1) CN113574109B (ko)
WO (1) WO2020185041A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102655181B1 (ko) * 2021-08-26 2024-04-04 중앙대학교 산학협력단 금 나노 입자를 이용한 세로토닌 검출 방법
WO2024035145A1 (ko) * 2022-08-10 2024-02-15 연세대학교 산학협력단 알데히드와 카테콜기가 도입된 전분 하이드로젤 및 이의 용도

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140127286A (ko) * 2012-02-28 2014-11-03 콘티프로 바이오테크 에스.알.오. 하이드로겔을 형성할 수 있는 히알루론산계 유도체, 이의 제조 방법, 상기 유도체를 기재로 하는 하이드로겔, 이의 제조 방법 및 용도
KR20170136178A (ko) * 2016-06-01 2017-12-11 한양대학교 산학협력단 히알루로네이트 기반 자가치유 하이드로젤 및 이의 용도
WO2018098299A1 (en) * 2016-11-23 2018-05-31 Trustees Of Tufts College Enzymatically crosslinked compositions
WO2018143736A1 (ko) * 2017-02-02 2018-08-09 (주)앰틱스바이오 갈롤기로 수식된 히알루론산 유도체를 기재로 하는 하이드로젤 및 이의 용도
KR20180105090A (ko) * 2017-03-14 2018-09-27 울산과학기술원 하이드로젤 패치

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
KR101040561B1 (ko) 2008-12-26 2011-06-16 아주대학교산학협력단 효소촉발형 생체주입형 하이드로젤과 그 생의학적 용도

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140127286A (ko) * 2012-02-28 2014-11-03 콘티프로 바이오테크 에스.알.오. 하이드로겔을 형성할 수 있는 히알루론산계 유도체, 이의 제조 방법, 상기 유도체를 기재로 하는 하이드로겔, 이의 제조 방법 및 용도
KR20170136178A (ko) * 2016-06-01 2017-12-11 한양대학교 산학협력단 히알루로네이트 기반 자가치유 하이드로젤 및 이의 용도
WO2018098299A1 (en) * 2016-11-23 2018-05-31 Trustees Of Tufts College Enzymatically crosslinked compositions
WO2018143736A1 (ko) * 2017-02-02 2018-08-09 (주)앰틱스바이오 갈롤기로 수식된 히알루론산 유도체를 기재로 하는 하이드로젤 및 이의 용도
KR20180105090A (ko) * 2017-03-14 2018-09-27 울산과학기술원 하이드로젤 패치

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CN113574109A (zh) 2021-10-29
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