WO2021107514A3 - 리피테그라스트의 제조방법 - Google Patents

리피테그라스트의 제조방법 Download PDF

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Publication number
WO2021107514A3
WO2021107514A3 PCT/KR2020/016487 KR2020016487W WO2021107514A3 WO 2021107514 A3 WO2021107514 A3 WO 2021107514A3 KR 2020016487 W KR2020016487 W KR 2020016487W WO 2021107514 A3 WO2021107514 A3 WO 2021107514A3
Authority
WO
WIPO (PCT)
Prior art keywords
lifitegrast
preparing
preparing lifitegrast
economically
effectively
Prior art date
Application number
PCT/KR2020/016487
Other languages
English (en)
French (fr)
Other versions
WO2021107514A2 (ko
Inventor
신현익
정은임
설창헌
Original Assignee
연성정밀화학(주)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 연성정밀화학(주) filed Critical 연성정밀화학(주)
Priority to US17/780,380 priority Critical patent/US20230027871A1/en
Publication of WO2021107514A2 publication Critical patent/WO2021107514A2/ko
Publication of WO2021107514A3 publication Critical patent/WO2021107514A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 고순도의 리피테그라스트를 효율적이고 경제적으로 제조하는 방법을 제공한다.
PCT/KR2020/016487 2019-11-27 2020-11-20 리피테그라스트의 제조방법 WO2021107514A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17/780,380 US20230027871A1 (en) 2019-11-27 2020-11-20 Method for preparing lifitegrast

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190154793A KR102362551B1 (ko) 2019-11-27 2019-11-27 리피테그라스트의 제조방법
KR10-2019-0154793 2019-11-27

Publications (2)

Publication Number Publication Date
WO2021107514A2 WO2021107514A2 (ko) 2021-06-03
WO2021107514A3 true WO2021107514A3 (ko) 2021-07-22

Family

ID=76130330

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2020/016487 WO2021107514A2 (ko) 2019-11-27 2020-11-20 리피테그라스트의 제조방법

Country Status (3)

Country Link
US (1) US20230027871A1 (ko)
KR (1) KR102362551B1 (ko)
WO (1) WO2021107514A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113880819A (zh) * 2021-09-18 2022-01-04 浙江大学医学院附属第一医院 立他司特的制备方法及其中间体化合物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106995439A (zh) * 2016-01-26 2017-08-01 镇江圣安医药有限公司 氘取代3‑(甲磺酰基)‑l‑苯丙氨酸衍生物及其药物组合物、药物制剂和用途
WO2019004936A1 (en) * 2017-06-30 2019-01-03 Scinopharm Taiwan, Ltd. PROCESS FOR THE PREPARATION OF LIFITEGRAST AND INTERMEDIATES THEREOF
WO2019043724A1 (en) * 2017-08-28 2019-03-07 Msn Laboratories Private Limited, R&D Center PROCESSES FOR THE PREPARATION OF (S) -2- (2- (BENZOFURAN-6-CARBONYL) -5,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXAMIDO) -3- (3) - (METHYLSULFONYL) PHENYL) PROPANOIC AND POLYMORPHS THEREOF
WO2019097547A1 (en) * 2017-11-15 2019-05-23 Cipla Limited An improved process for the preparation of lifitegrast or salts thereof
WO2019186520A1 (en) * 2018-03-31 2019-10-03 Aurobindo Pharma Limited A process for the preparation of lifitegrast

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2383525T3 (es) 2003-11-05 2012-06-21 Sarcode Bioscience Inc. Moduladores de la adhesión celular

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106995439A (zh) * 2016-01-26 2017-08-01 镇江圣安医药有限公司 氘取代3‑(甲磺酰基)‑l‑苯丙氨酸衍生物及其药物组合物、药物制剂和用途
WO2019004936A1 (en) * 2017-06-30 2019-01-03 Scinopharm Taiwan, Ltd. PROCESS FOR THE PREPARATION OF LIFITEGRAST AND INTERMEDIATES THEREOF
WO2019043724A1 (en) * 2017-08-28 2019-03-07 Msn Laboratories Private Limited, R&D Center PROCESSES FOR THE PREPARATION OF (S) -2- (2- (BENZOFURAN-6-CARBONYL) -5,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXAMIDO) -3- (3) - (METHYLSULFONYL) PHENYL) PROPANOIC AND POLYMORPHS THEREOF
WO2019097547A1 (en) * 2017-11-15 2019-05-23 Cipla Limited An improved process for the preparation of lifitegrast or salts thereof
WO2019186520A1 (en) * 2018-03-31 2019-10-03 Aurobindo Pharma Limited A process for the preparation of lifitegrast

Also Published As

Publication number Publication date
WO2021107514A2 (ko) 2021-06-03
US20230027871A1 (en) 2023-01-26
KR20210065720A (ko) 2021-06-04
KR102362551B1 (ko) 2022-02-15

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