WO2020173511A3 - 一种佐剂生物活性的检测方法 - Google Patents
一种佐剂生物活性的检测方法 Download PDFInfo
- Publication number
- WO2020173511A3 WO2020173511A3 PCT/CN2020/087534 CN2020087534W WO2020173511A3 WO 2020173511 A3 WO2020173511 A3 WO 2020173511A3 CN 2020087534 W CN2020087534 W CN 2020087534W WO 2020173511 A3 WO2020173511 A3 WO 2020173511A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- adjuvant
- biological activity
- measuring
- present
- quality
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
一种佐剂生物活性的检测方法,包括以下步骤:将佐剂或佐剂/共刺激物混合物作用于细胞模型;检测细胞模型分泌的蛋白因子量,用以表征佐剂的生物学活性。该检测方法及相应的检测试剂能精确鉴别不同佐剂的生物学活性,从而简化了佐剂的评价手段,该检测方法易操作、实用性强、应用面广,可应用于含佐剂疫苗质量的快速评价中。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910153732.7A CN109752560A (zh) | 2019-02-28 | 2019-02-28 | 一种佐剂生物活性的检测方法 |
CN201910153732.7 | 2019-02-28 | ||
CN202010115594.6 | 2020-02-25 | ||
CN202010115594.6A CN111122878B (zh) | 2019-02-28 | 2020-02-25 | 一种佐剂生物活性的检测方法 |
Publications (2)
Publication Number | Publication Date |
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WO2020173511A2 WO2020173511A2 (zh) | 2020-09-03 |
WO2020173511A3 true WO2020173511A3 (zh) | 2020-10-22 |
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PCT/CN2020/087534 WO2020173511A2 (zh) | 2019-02-28 | 2020-04-28 | 一种佐剂生物活性的检测方法 |
Country Status (2)
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CN (2) | CN109752560A (zh) |
WO (1) | WO2020173511A2 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109752560A (zh) * | 2019-02-28 | 2019-05-14 | 艾棣维欣(苏州)生物制药有限公司 | 一种佐剂生物活性的检测方法 |
CN110456042B (zh) * | 2019-08-09 | 2022-07-05 | 臻悦生物科技江苏有限公司 | 血清学生物标志物在制备试剂盒和/或芯片中的应用、试剂盒或芯片及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120258125A1 (en) * | 2011-04-06 | 2012-10-11 | Lancell, L.L.C. | Method to identify a novel class of immunologic adjuvants |
CN103412085A (zh) * | 2013-08-27 | 2013-11-27 | 成都生物制品研究所有限责任公司 | 一种氨水制备的氢氧化铝佐剂吸附能力的检测方法 |
CN106456745A (zh) * | 2014-02-11 | 2017-02-22 | 北京艾棣维欣生物技术有限公司 | 具有白细胞介素‑17作为佐剂的疫苗 |
JP2018068177A (ja) * | 2016-10-27 | 2018-05-10 | 日清食品ホールディングス株式会社 | アジュバント作用の評価法 |
CN109752560A (zh) * | 2019-02-28 | 2019-05-14 | 艾棣维欣(苏州)生物制药有限公司 | 一种佐剂生物活性的检测方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE403867T1 (de) * | 2003-08-05 | 2008-08-15 | Alk Abello As | Evaluierung adjuvanshaltiger impfstoffe |
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2019
- 2019-02-28 CN CN201910153732.7A patent/CN109752560A/zh active Pending
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2020
- 2020-02-25 CN CN202010115594.6A patent/CN111122878B/zh active Active
- 2020-04-28 WO PCT/CN2020/087534 patent/WO2020173511A2/zh active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120258125A1 (en) * | 2011-04-06 | 2012-10-11 | Lancell, L.L.C. | Method to identify a novel class of immunologic adjuvants |
CN103412085A (zh) * | 2013-08-27 | 2013-11-27 | 成都生物制品研究所有限责任公司 | 一种氨水制备的氢氧化铝佐剂吸附能力的检测方法 |
CN106456745A (zh) * | 2014-02-11 | 2017-02-22 | 北京艾棣维欣生物技术有限公司 | 具有白细胞介素‑17作为佐剂的疫苗 |
JP2018068177A (ja) * | 2016-10-27 | 2018-05-10 | 日清食品ホールディングス株式会社 | アジュバント作用の評価法 |
CN109752560A (zh) * | 2019-02-28 | 2019-05-14 | 艾棣维欣(苏州)生物制药有限公司 | 一种佐剂生物活性的检测方法 |
Non-Patent Citations (3)
Title |
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TINCER, GIZEM ET AL.: "Immunostimulatory activity of polysaccharide-poly(I:C) nanoparticles", BIOMATERIALS, vol. 32, no. 18, 2 April 2011 (2011-04-02), XP028245762, ISSN: 0142-9612, DOI: 20200626103128Y * |
WANG, HUI: "Immunoregulation of the Polysaccharides from the Roots of Actinidia Eriantha on RAW264.7 Cell and Its Mechanisms", WANFANG DATA, 22 May 2014 (2014-05-22), DOI: 20200626102054X * |
WANG, HUI: "Immunoregulation of the Polysaccharides from the Roots of Actinidia Eriantha on RAW264.7 Cell and Its Mechanisms", WANFANG DATA, 22 May 2014 (2014-05-22), DOI: 20200626102102Y * |
Also Published As
Publication number | Publication date |
---|---|
WO2020173511A2 (zh) | 2020-09-03 |
CN111122878A (zh) | 2020-05-08 |
CN109752560A (zh) | 2019-05-14 |
CN111122878B (zh) | 2020-11-20 |
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