WO2020166744A1 - Procédé de soulèvement de peau utilisant une micro-aiguille ayant une structure déformée et un pansement cutané - Google Patents

Procédé de soulèvement de peau utilisant une micro-aiguille ayant une structure déformée et un pansement cutané Download PDF

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Publication number
WO2020166744A1
WO2020166744A1 PCT/KR2019/001858 KR2019001858W WO2020166744A1 WO 2020166744 A1 WO2020166744 A1 WO 2020166744A1 KR 2019001858 W KR2019001858 W KR 2019001858W WO 2020166744 A1 WO2020166744 A1 WO 2020166744A1
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WO
WIPO (PCT)
Prior art keywords
skin
layer
microneedle
contraction
dressing pad
Prior art date
Application number
PCT/KR2019/001858
Other languages
English (en)
Korean (ko)
Inventor
이진우
Original Assignee
주식회사 하이로닉
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 하이로닉 filed Critical 주식회사 하이로닉
Priority to PCT/KR2019/001858 priority Critical patent/WO2020166744A1/fr
Publication of WO2020166744A1 publication Critical patent/WO2020166744A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the present invention relates to a skin lifting method using a deformable structure needle, and more specifically, a skin lifting procedure that removes a part of skin tissue by perforating the skin, and a hollow type having a structure curved in a ⁇ shape inward. It relates to a method of performing using a microneedle.
  • the most effective skin lifting procedure is to remove the actual skin tissue.
  • surgical therapy may have side effects.
  • the face may become asymmetric after surgery. Inflammation may result, taking antibiotics or facial nerve palsy.
  • a procedure to meet these demands is a method of skin lifting procedure, and refers to a procedure in which unnecessary skin tissue is removed multiplexedly at once in a micro unit without scars or surgery using a microneedle.
  • a needle is penetrated into a skin target area, and the skin tissue of the pierced area is removed.
  • a drug is injected into the area where the skin tissue has been removed and then shielding it, it is a procedure that internally induces skin regeneration, thereby increasing skin elasticity.
  • the present invention provides a skin lifting method using a microneedle having a structure curved in a ⁇ -shape in order to facilitate skin perforation in a skin lifting procedure using a microneedle.
  • the present invention provides a skin lifting method using a skin dressing pad capable of helping regeneration of perforated skin in a skin lifting procedure using a microneedle.
  • the skin lifting method using the modified structure microneedle and the skin dressing pad according to the present invention includes the steps of adhering the skin dressing pad to the skin, and the skin is punctured using the microneedle to remove part of the skin tissue, and the punctured Including the step of injecting a drug for skin lifting into the skin and closing the perforated skin while the skin dressing pad is contracted, the microneedle is a hollow microneedle having a structure curved inwardly in a ⁇ shape. It can be a needle.
  • the microneedle may have a horizontal axis and a vertical axis formed in a ratio of 1 to 2, respectively.
  • the microneedles may have an inclination of 24 degrees.
  • the skin dressing pad covers the skin so as to facilitate the perforation of the skin by the microneedles to flatten the skin surface, and to close the skin perforated by the microneedles.
  • it may include a contraction layer for contracting the skin surface, and an adhesive layer for bonding the skin support layer and the contraction layer to the skin.
  • the skin dressing pad may further include a hemostatic layer for stopping bleeding that occurs when the skin is punctured by the microneedles.
  • the shrinking layer may include a stimulus sensitive material capable of shrinking according to a change in temperature or moisture content.
  • the skin support layer may be interposed between the contraction layer and the adhesive layer.
  • the skin support layer is made of an expandable material, and the contraction layer may contract in one direction or in one of a first direction and a second direction perpendicular to each other.
  • a skin lifting method using a microneedle having a structure curved inwardly in a ⁇ shape can be provided.
  • the present invention in a skin lifting procedure using a microneedle, it is possible to provide a skin lifting method using a skin dressing pad that can help regeneration of perforated skin.
  • FIG. 1 is a view showing a process of using a microneedle and a skin dressing pad according to an embodiment.
  • FIG. 2 is a view showing a microneedle according to an embodiment.
  • FIG 3 is another diagram showing a microneedle according to an embodiment.
  • FIG. 4 is another diagram showing a microneedle according to an embodiment.
  • FIG. 5 is a view showing a side of a microneedle according to an embodiment.
  • FIG. 6 is a view showing a perspective view of a skin dressing pad according to an embodiment.
  • FIG. 7 is a diagram illustrating a cross-sectional view of a skin dressing pad according to an exemplary embodiment.
  • the skin dressing pad 100 is first adhered to the skin 10, and the microneedles 20 are attached.
  • the skin 10 is punctured using the skin 10 to remove a part of the tissue, and a drug for lifting is injected.
  • the skin dressing pad 100 is contracted and the perforated skin 10 is closed.
  • the procedure of regenerating (10) may be performed, and the skin 10 of the person to be treated may be lifted through such a procedure.
  • the microneedle 20 serves to perforate the skin to remove part of the tissue of the skin 10, and the skin dressing pad 100 is used to facilitate the perforation of the skin 10 by the microneedle 20.
  • the skin 10 can be supported, bleeding of the perforated area 12 can be stopped, and regeneration of the skin 10 of the perforated area 12 can be promoted.
  • the microneedle 20 may be a hollow microneedle having a structure curved inwardly in a ⁇ shape.
  • the tip of the needle is formed in a V-shape
  • the skin tissue is removed in a V-shape, thereby forming a V-shaped perforated skin.
  • the microneedle 20 of the present invention may be a hollow microneedle having a structure curved inwardly in a ⁇ shape, as shown in FIG. 2.
  • the microneedle 20 has a structure in which the microneedle 20 is curved inwardly in a ⁇ shape as in the present invention, when the skin is punctured using the needle, the skin tissue is removed in a ⁇ shape, and the ⁇ -shaped perforated skin is Is formed.
  • the administered drug stays in the skin for a longer time.
  • the drug may flow out from the perforated skin as soon as the microneedles are removed.
  • the drug stays at the bottom of both sides. The amount of drug flowing out of the perforated skin can be significantly reduced.
  • the ⁇ -shaped microneedle 20 of the present invention When the skin is punctured by using, it may function to retain the drug after administration and improve the consistency of administration.
  • the needle part 30 of the present invention may be formed by including one or more hollow microneedles 20 having a structure curved in a ⁇ shape inward, and accordingly It is possible to apply the above effect of the present invention to a large area of skin.
  • perforating the skin using the microneedle 20 may mean incision or ablation of the skin.
  • incision means cutting, abrasion, destruction or cutting of skin tissue.
  • an incision can cut, wear, or destroy skin tissue or portions thereof, thereby creating one or more holes in the skin area.
  • ablation refers to the action of removing skin tissue from the skin area.
  • ablation may remove skin tissue to have a specific structure, thereby creating one or more holes in the skin region, that is, a sound space generated by removal of the tissue.
  • the skin region may include a plurality of cut tissue portions and/or ablated tissue portions (eg, a plurality of holes).
  • a hollow microneedle having a structure curved in a ⁇ shape inward may have a horizontal axis and a vertical axis formed in a ratio of 1 to 2, respectively.
  • the needle structure is formed in a ratio of 1 to 2 on the horizontal axis and the vertical axis as in the present invention, since the horizontal axis is narrower than the vertical axis, skin perforation can not be performed over a large area, thereby preventing the occurrence of scars on the skin epidermal layer.
  • the vertical axis is wider than the horizontal axis, there is an advantage that a perforation can be made to the dermal layer of the skin, and accordingly, a drug can be injected deep into the skin.
  • the horizontal axis and the vertical axis each have a ratio of 1 to 2, and it is obvious to include other ratios (eg, 2 to 4, 3 to 6, etc.) that maintain the ratio.
  • the inclination of the microneedle 20 is so that it can be smoothly introduced into the inside of the skin when the skin is punctured. It can be formed to be 24 degrees.
  • the skin dressing pad 100 may support the skin to facilitate skin perforation by the microneedle 20, prevent bleeding at the perforated portion, and promote skin regeneration at the perforated portion.
  • the skin support layer 110 of the skin dressing pad 100 may be interposed between the contraction layer 130 and the adhesive layer 140.
  • the skin support layer 110 may be disposed on the lower surface of the hemostatic layer 120.
  • the skin support layer 110 may cover the skin to facilitate skin perforation using the microneedles 20 to support the skin surface flat. Specifically, the skin support layer 110 may spread the skin evenly so that a predetermined position can be punctured using a plurality of microneedles 20.
  • the skin support layer 110 may be, for example, a flexible film made of synthetic resin, and has a certain degree of rigidity to maintain the basic shape of a flat sheet, so when the skin support layer 110 is adhered to the skin surface, the skin support layer ( The skin surface may be evenly spread to correspond to the planar shape of 110).
  • the hemostatic layer 120 may be disposed on the upper surface of the skin support layer 110, and react with blood to stop bleeding that occurs during skin perforation.
  • the hemostatic layer 120 may entirely cover the perforated area 12 of the skin, and contains a hemostatic agent that reacts with blood, so that the blood coagulates to stop bleeding.
  • the hemostatic action is possible through the compression of the bleeding area, and thus, some hemostatic effect can be achieved by closing the skin by the contraction layer 130 to be described later.
  • the skin support layer 110 and the hemostatic layer 120 may be integrally formed as one layer.
  • the skin support layer 110 may be made of an absorbent material capable of absorbing a hemostatic component.
  • the contraction layer 130 and the hemostatic layer 120 may be formed as one layer.
  • the contraction layer 130 may be closed by contracting the skin surface of the perforated area in order to promote regeneration of the perforated skin.
  • the contraction layer 130 may be formed of a stimulus-sensitive material in which contraction occurs in response to temperature, pH, light, moisture, chemical exposure, electricity, and magnetic fields.
  • the contraction direction of the contraction layer 130 may be adjusted as necessary.
  • contraction layer 130 contracts according to the temperature change
  • contraction may occur when the contraction layer 130 reaches a preset temperature.
  • the preset temperature is equal to the body temperature, the body temperature when adhered to the skin This can cause contraction.
  • the preset temperature at which the contraction layer 130 contracts is set lower than the body temperature, the contraction layer 130 may reach a preset temperature according to a change in external temperature due to cooling or the like, and contraction may occur.
  • the shrinkage layer 130 may shrink when moisture included in the shrinkage evaporates.
  • the volume may be reduced and shrinkage may occur.
  • the shrinking layer 130 may shrink in one direction. When contraction occurs in one direction, it is possible to provide an effect of lifting the skin in one direction in a skin lifting procedure.
  • the contraction layer 130 may contract in a first direction and a second direction perpendicular to each other on a plane. Through this, the first direction and the second direction are combined to cause contraction, thereby providing a tightening effect in all directions on a plane.
  • the shrinking layer 130 may be contracted in a direction in which the size of the punctured portion is reduced when puncturing occurs by the microneedle 20. Specifically, when a physical change occurs due to perforation of the microneedle 20, the shrinking layer 130 may shrink in a direction in which the size of the perforated portion is reduced.
  • the shrinking layer 130 may shrink only the periphery of the perforated portion 12 to close the perforated portion.
  • the contraction layer 130 may contain a collagen component to promote skin regeneration.
  • Skin regeneration such as EGF (Epidermal Growth Factor) below any one of the above-described adhesive layer 140, skin support layer 110, hemostatic layer 120, and contraction layer 130 in contact with the skin A material that assists in may be applied.
  • EGF Epidermal Growth Factor
  • the skin dressing pad 100 of the present invention may be made of a transparent material so that the skin condition can be checked without removing the pad when the skin is attached.
  • the skin dressing pad 100 includes any one of the adhesive layer 140, the skin support layer 110, the hemostatic layer 120, and the contraction layer 130 so that the treatment site is not conspicuous during skin attachment. It can be composed of.
  • a cover layer made of an opaque flesh-colored material may be further included.
  • the pad 100 for skin dressing of the present invention includes a hemostatic layer 120, a skin support layer 110, and a contraction layer 130 on the adhesive layer 140. These can be placed sequentially. That is, in the case of this embodiment, unlike the embodiment of FIG. 6, the hemostatic layer 120 may be formed below the skin support layer 110. Therefore, since the hemostatic layer 120 is disposed closer to the skin, it is possible to stably stop bleeding when bleeding occurs due to skin perforation.
  • the skin lifting method using the modified structure microneedle and the skin dressing pad according to the present invention can be used in various skin lifting methods.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne un procédé de soulèvement de la peau utilisant une micro-aiguille ayant une structure déformée et un pansement cutané et, plus particulièrement, un procédé de soulèvement de la peau comprenant les étapes consistant à : fixer le pansement cutané sur une peau ; perforer la peau à l'aide de la micro-aiguille pour retirer une partie du tissu cutané et injecter un médicament pour le soulèvement de la peau dans la peau perforée ; et fermer la peau perforée par la contraction du pansement cutané, la micro-aiguille pouvant être une micro-aiguille creuse qui a une structure incurvée vers l'intérieur pourvue d'une forme en ∩.
PCT/KR2019/001858 2019-02-15 2019-02-15 Procédé de soulèvement de peau utilisant une micro-aiguille ayant une structure déformée et un pansement cutané WO2020166744A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/KR2019/001858 WO2020166744A1 (fr) 2019-02-15 2019-02-15 Procédé de soulèvement de peau utilisant une micro-aiguille ayant une structure déformée et un pansement cutané

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2019/001858 WO2020166744A1 (fr) 2019-02-15 2019-02-15 Procédé de soulèvement de peau utilisant une micro-aiguille ayant une structure déformée et un pansement cutané

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WO2020166744A1 true WO2020166744A1 (fr) 2020-08-20

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113209001A (zh) * 2021-05-17 2021-08-06 哈尔滨医科大学 祛疤微针贴
CN115025276A (zh) * 2022-06-21 2022-09-09 武汉大学中南医院 一种含有阳离子盐的光交联微针材料及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6261795B2 (fr) * 1976-12-13 1987-12-23 Eritetsukusu Konserun Tekusuteiruniho Sutorojirensutoi
KR20110083709A (ko) * 2008-11-07 2011-07-20 케이씨아이 라이센싱 인코포레이티드 감압 상처 치료 드레싱 및 시스템
WO2013188884A1 (fr) * 2012-06-15 2013-12-19 University Of Washington Through Its Center For Commercialization Dispositifs de fermeture de plaie, basés sur une microstructure
KR20140010430A (ko) * 2011-03-03 2014-01-24 네오다인 바이오사이언시스, 인코포레이티드 피부 타이트닝을 위한 장치 및 방법
KR101386490B1 (ko) * 2012-06-14 2014-04-21 (주)지에프씨 마이크로니들 어레이 및 이를 구비하는 피부침투장치
JP6375435B1 (ja) * 2017-12-26 2018-08-15 三島光産株式会社 マイクロニードルアレイ

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6261795B2 (fr) * 1976-12-13 1987-12-23 Eritetsukusu Konserun Tekusuteiruniho Sutorojirensutoi
KR20110083709A (ko) * 2008-11-07 2011-07-20 케이씨아이 라이센싱 인코포레이티드 감압 상처 치료 드레싱 및 시스템
KR20140010430A (ko) * 2011-03-03 2014-01-24 네오다인 바이오사이언시스, 인코포레이티드 피부 타이트닝을 위한 장치 및 방법
KR101386490B1 (ko) * 2012-06-14 2014-04-21 (주)지에프씨 마이크로니들 어레이 및 이를 구비하는 피부침투장치
WO2013188884A1 (fr) * 2012-06-15 2013-12-19 University Of Washington Through Its Center For Commercialization Dispositifs de fermeture de plaie, basés sur une microstructure
JP6375435B1 (ja) * 2017-12-26 2018-08-15 三島光産株式会社 マイクロニードルアレイ

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113209001A (zh) * 2021-05-17 2021-08-06 哈尔滨医科大学 祛疤微针贴
CN113209001B (zh) * 2021-05-17 2024-04-16 哈尔滨医科大学 祛疤微针贴
CN115025276A (zh) * 2022-06-21 2022-09-09 武汉大学中南医院 一种含有阳离子盐的光交联微针材料及其制备方法和应用
CN115025276B (zh) * 2022-06-21 2023-09-19 武汉大学中南医院 一种含有阳离子盐的光交联微针材料及其制备方法和应用

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