WO2020152991A1 - Système d'analyse automatique et procédé de transport d'échantillon - Google Patents

Système d'analyse automatique et procédé de transport d'échantillon Download PDF

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Publication number
WO2020152991A1
WO2020152991A1 PCT/JP2019/047051 JP2019047051W WO2020152991A1 WO 2020152991 A1 WO2020152991 A1 WO 2020152991A1 JP 2019047051 W JP2019047051 W JP 2019047051W WO 2020152991 A1 WO2020152991 A1 WO 2020152991A1
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WO
WIPO (PCT)
Prior art keywords
sample
dispensing
sample rack
line
analysis system
Prior art date
Application number
PCT/JP2019/047051
Other languages
English (en)
Japanese (ja)
Inventor
慧 中島
晃啓 安居
武 瀬戸丸
Original Assignee
株式会社日立ハイテク
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社日立ハイテク filed Critical 株式会社日立ハイテク
Priority to JP2020567395A priority Critical patent/JP7053898B2/ja
Priority to CN201980078369.5A priority patent/CN113874730A/zh
Priority to EP19910927.3A priority patent/EP3916396B1/fr
Priority to US17/294,190 priority patent/US20220011333A1/en
Publication of WO2020152991A1 publication Critical patent/WO2020152991A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/0092—Scheduling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0412—Block or rack elements with a single row of samples
    • G01N2035/0413—Block or rack elements with a single row of samples moving in one dimension
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0441—Rotary sample carriers, i.e. carousels for samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0465—Loading or unloading the conveyor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes

Definitions

  • the present invention provides an automatic analysis system for measuring the concentration and activity value of a target component in a biological sample (hereinafter referred to as a sample) such as plasma, serum, urine, and a sample suitable for such an automatic analysis system. It depends on the transportation method.
  • a biological sample hereinafter referred to as plasma, serum, urine, and a sample suitable for such an automatic analysis system. It depends on the transportation method.
  • Patent Document 1 has a standby disk that can be rotated and stopped while a plurality of racks are on standby, and a dedicated rack reciprocating transfer line is provided between each analysis unit and the standby disk. Further, it is described that only a single rack is guided to each rack reciprocating transfer line, and the rack is returned to the standby disk after the sampling process.
  • An automatic analysis system is an apparatus for automatically analyzing such a sample.
  • Automatic analysis system uses different measurement methods depending on the item of the component to be measured. For example, an assay method (colorimetric analysis) that uses a reagent that reacts with the analyte component in the sample to change the color of the reaction solution, or a substance that binds directly or indirectly to the analyte component A function is provided for executing an analytical method (immunological analysis) for counting labeled substances using a reagent added with.
  • an assay method colorimetric analysis
  • analytical method immunological analysis
  • the automatic analysis system has a stand-alone type that operates the analysis unit that analyzes the sample as an independent device.
  • a plurality of analysis modules in different analytical fields such as biochemistry and immunity are connected by a transport line that transports a sample rack that holds sample containers that store samples and operate as one system.
  • Known module types and the like are connected by a transport line that transports a sample rack that holds sample containers that store samples and operate as one system.
  • Patent Document 1 a configuration in which a plurality of analysis modules are arranged so as to be connected to one sample rack distribution module along a transport line composed of a belt conveyor, and a plurality of sample racks are held, are different.
  • a configuration is described in which a plurality of analysis units are connected via a rotor-type sample rack distribution module that can be exchanged with an analysis module or a plurality of analysis modules in the same field.
  • a transport method of supplying a sample from a common mechanism that distributes sample racks to a plurality of different analysis units. is necessary.
  • the reagent disks in the left and right analysis modules in the figure are arranged rotationally symmetrical with respect to a line passing through the rotation center of the rack standby disk. For this reason, when accessing the reagent disk of the left analysis unit after accessing the reagent disk of the right analysis unit in the figure, it is necessary to make a half round around the system, and it can be said that the accessibility is sufficiently good for the user. No, there is room for improvement.
  • the present invention has been made in view of the above-mentioned problems, and even if the sample is supplied from a common sample rack distribution module to a plurality of analysis modules, the transport efficiency of the sample rack is improved and the accessibility of the user is improved. It is an object to provide a good automatic analysis system and a method for transporting a sample rack.
  • the present invention includes a plurality of means for solving the above problems, and if one example is given, a plurality of analysis modules for analyzing a sample by mixing it with a reagent, and a sample holding a sample container accommodating the sample A transport line for transporting the rack, and a sample rack distribution module that has a rotatable standby disk in which a plurality of holding units capable of holding the sample rack are formed and that supplies the sample rack to the analysis module.
  • the analysis module respectively draws and delivers the sample rack from the sample rack distribution module to the sample dispensing position by the sample dispensing mechanism, and a sample dispensing mechanism that dispenses the sample held in the sample rack.
  • a dispensing line for performing, the transport line, and the plurality of dispensing lines are arranged so as not to be parallel to each other, and the analysis is arranged with the sample rack distribution module sandwiched therebetween.
  • the device layout of the module is axisymmetric with respect to a straight line passing through the rotation center of the standby disk.
  • FIG. 3 is a diagram showing an outline of a sample rack suitably used in the automatic analysis system according to the first embodiment.
  • FIG. 3 is a diagram showing an outline of the structure of a transporting convex portion in the automatic analysis system according to the first embodiment. It is a figure which shows the structure which looked at the automatic analysis system shown in FIG. 1 from the XX' direction. It is a figure showing an example of arrangement of a sample rack distribution module and an analysis module in an automatic analysis system of the prior art for comparison. It is a figure which shows another example of arrangement
  • FIG. 6 is a diagram showing another example of the arrangement of the sample rack distribution module and the analysis module in the automatic analysis system according to the first embodiment. 6 is a matrix for explaining the effect of shortening the transportation time in the automatic analysis system according to the first embodiment. It is a figure which shows the example of arrangement
  • FIG. 8 is a diagram showing an example of arrangement of a sample rack distribution module and an analysis module in the automatic analysis system according to the second embodiment.
  • FIG. 8 is a diagram showing an outline of an operation range of a transporting convex portion in the automatic analysis system according to the second embodiment.
  • FIG. 9 is a diagram illustrating the operation of the transporting convex portion and the operation of the sample rack distribution module in the automatic analysis system according to the second embodiment.
  • FIG. 9 is a diagram illustrating the operation of the transporting convex portion and the operation of the sample rack distribution module in the automatic analysis system according to the second embodiment.
  • FIG. 9 is a diagram illustrating the operation of the transporting convex portion and the operation of the sample rack distribution module in the automatic analysis system according to the second embodiment.
  • 9 is a time chart explaining the effect of shortening the transportation time by the sample rack transportation method in the automatic analysis system according to the second embodiment.
  • 9 is a time chart explaining the effect of shortening the transportation time by the sample rack transportation method in the automatic analysis system according to the second embodiment.
  • 9 is a time chart explaining the effect of shortening the transportation time by the sample rack transportation method in the automatic analysis system according to the second embodiment.
  • 9 is a time chart explaining the effect of shortening the transportation time by the sample rack transportation method in the automatic analysis system according to the second embodiment.
  • Example 1 of the automatic analysis system and sample transport method of the present invention will be described with reference to FIGS. 1 to 9.
  • FIG. 1 is a diagram showing the basic configuration of the automatic analysis system according to the present embodiment.
  • the automatic analysis system 1 shown in FIG. 1 is configured to analyze a sample of plasma, serum or urine, and two different analysis modules 200, 300 are connected via one sample rack distribution module 100. An example of connection is shown. In addition, a configuration is shown in which a biochemical analysis module is connected as the analysis module 200 and an immune analysis module is connected as the analysis module 300.
  • analysis modules to be connected are not limited to these, and other analysis modules such as a blood coagulation analysis module and analysis modules that perform the same type of analysis on the left and right can be appropriately arranged according to the usage environment. Further, the number of analysis modules connected is not limited to two, but can be three or more.
  • the module-type automatic analysis system 1 of the present embodiment shown in FIG. 1 is equipped with two analysis modules 200, 300 and one or more sample containers 12 (see FIG. 2, etc.) containing a sample to be analyzed.
  • the sample rack distribution module 100 has a transport line 104 for transporting sample racks, and a control device 400 for controlling the operation of the automatic analysis system 1 as a whole.
  • a sample rack 10 handled by the automatic analysis system 1 is equipped with one or more sample containers 12 containing samples to be subjected to qualitative/quantitative analysis in the automatic analysis system 1.
  • the sample rack at least the sample rack 10 in which the sample container 12 containing the sample (normal sample) to be analyzed with the normal priority is mounted, and the urgency of the analytical measurement is higher than that of the sample rack.
  • an emergency sample rack 11 on which a sample container containing a high emergency sample is mounted.
  • the sample rack distribution module 100 is a device that supplies the sample rack 10 holding the sample container 12 containing the sample and the emergency sample rack 11 to the analysis modules 200 and 300 connected to both sides via the standby disk 106. It has a sample rack loading unit 102, an emergency sample rack loading unit 112, a sample identification device 105, a transport line 104, a standby disk 106, a sample rack unloading unit 103, and a transport module control unit 101.
  • the sample rack loading section 102 is provided on the side surface side of the transport line 104, and supplies the sample rack 10 on which a normal sample is loaded to the transport line 104.
  • the sample rack unloading unit 103 is provided on the side surface side of the transport line 104 similarly to the sample rack unloading unit 102, and stores the sample rack 10 unloaded from the transport line 104.
  • the emergency sample rack standby area 113 is provided on the transport line 104 and is an area in which the emergency sample rack 11 can be temporarily put on standby.
  • the sample identifying device 105 is a device for inquiring the analysis request information regarding the sample contained in the sample container 10 mounted on the sample rack 10 or the emergency sample rack 11 transported on the transport line 104.
  • the identification medium (not shown) such as an RFID or a barcode provided on the emergency sample rack 11 or the sample container 12 is read and identified.
  • the standby disk 106 is a disk that is arranged at one end of the transport line 104 and has a plurality of one or more slots 106A that can mount the sample rack 10 and the like on the outer circumference, and has a rotor structure that performs circular motion. ing.
  • the standby disk 106 is configured to transfer the sample rack 10 between one end of the transport line 104, one end of the dispensing line 209 of the analysis module 200, and one end of the dispensing line 309 of the analysis module 300. Has been done.
  • the transfer line 104 is connected to a certain point on the radial circumference of the standby disk 106, and the sample rack 10 is loaded and unloaded. Assuming that this one point is a position of 0° on the circumference, the analysis module is placed at a position (90° counterclockwise in FIG. 1) other than a position (180°) parallel to the position to which the transfer line 104 is connected. 200 dispensing lines 209 are connected.
  • the dispensing line 309 of the analysis module 300 is connected to a position (108° clockwise in FIG. 1) other than the position (180°) parallel to the position to which the transport line 104 is connected.
  • the dispensing line 209 and the dispensing line 309 are arranged so as not to be parallel to each other.
  • a line extending in the carrying direction of the sample rack 10 or the like of the dispensing line 209 or a line extending in the carrying direction of the sample rack 10 or the like of the dispensing line 309 is the standby disk 106. Is arranged so as to pass through the slot 106A.
  • the sample rack distribution module 100 and the two left and right analysis modules 200 and 300 are connected to each other when the dispensing lines 209 and 309 of one of the analysis modules 200 and 300 are connected to the slot 106A of the standby disk 106.
  • the dispensing lines 209 and 309 of the analysis modules 200 and 300 are also arranged so as to be connected to the slot 106A.
  • dispensing lines 209 and 309 are connected to each other in the direction that extends radially from the center of the standby disk 106 .
  • the dispensing lines 209 and 309 and the slot 106A are connected to the standby disk 106. It does not need to be arranged and formed in a direction that extends radially from the center of the.
  • the sample rack 10 accommodated in the standby disk 106 has address information for identifying which position the slot 106A holds. Therefore, the position of the slot 106A that is returned after being conveyed to the dispensing lines 209 and 309 is the same slot 106A in the standby disk 106. That is, the standby disk 106 rotates, the original slot 106A stops at the position where it is connected to the respective dispensing lines 209 and 309, and the sample rack 10 is received from the dispensing lines 209 and 309.
  • sample rack 10 newly transferred from the transfer line 104 is basically stored in the next (one next to) position after the last storage position.
  • the sample rack 10 that has been dispensed by the analysis module 200 and the analysis module 300 waits for the output of the measurement result in the standby disk 106, and can be subjected to processing such as automatic retesting if necessary. Further, when the processing is completed, the sample is carried to the sample rack unloading section 103 via the carrying line 104.
  • the transport module control unit 101 performs an operation of transporting an appropriate sample rack 10 from the standby disk 106 to the dispensing lines 209 and 309, and a transport operation of returning the sample rack 10 and the like from the dispensing lines 209 and 309 to the standby disk 106. This is a part that executes control, and controls the operation of each mechanism based on a command from the control device 400 described later.
  • the analysis modules 200 and 300 are modules that perform sampling (dispensing) on the sample contained in the sample container 12 mounted on the sample rack 10 and the like, and mix with a reagent to perform qualitative/quantitative analysis.
  • the analysis module 200 measures the dispensing line 209, the sample identifying device 210, the sample dispensing mechanism 208, the reaction disk 211, and the mixed liquid (reaction liquid) of the sample and the reagent dispensed into the reaction container to perform qualitative/quantitative determination.
  • the measuring unit 217 for analysis, the reagent dispensing mechanism 219, the reagent disc 218, the control unit 201, and the like are provided.
  • the dispensing line 209 is a transport mechanism capable of reciprocating the retracting and delivering of the sample rack 10 and the like from the standby disk 106 of the sample rack distribution module 100 to the sample dispensing position by the sample dispensing mechanism 208.
  • a transporting convex portion 220 that fits into a concave portion 13 provided on the bottom surface of the sample rack 10 as shown in FIG. 2 for transporting, and a transporting convex portion 220 for moving. It is composed of a rail 220A, a motor 220B, and the like.
  • One of the transporting protrusions 220 is provided on the dispensing line 209, and the operating range thereof is from the end of the dispensing line 209 to the inside of the slot 106A of the standby disk 106. Inside the standby disk 106, it is possible to rotate 360° while keeping the transporting convex portion 220 on the standby disk 106 side.
  • the sample rack 10 can be transported within the operation range of the transporting protrusion 220.
  • the standby disk 106 is stopped during the transfer of the sample rack 10 to and from the dispensing line 209, but when the transfer is completed, the place where the next sample rack 10 is transferred is connected to the dispensing line 209. Rotate to position.
  • dispensing line 209 the case where a configuration in which a protruding structure driven along the dispensing line 209 is fitted into a concave portion 13 provided in advance in the sample rack 10 and transported is adopted is illustrated.
  • a belt conveyor type transport mechanism can be adopted.
  • Such a mechanism is the same in the transfer line 104 and the dispensing line 309 of the analysis module 300, which will be described later, and one transfer protrusion 120 and 320 is provided.
  • the sample identifying device 210 identifies the RFID or barcode provided on the sample rack 10 and the sample container 12 for collating the analysis request information for the sample contained in the sample rack 10 drawn in by the dispensing line 209. It is a device for reading a medium (not shown).
  • the sample dispensing mechanism 208 can rotate and move up and down, and moves above the sample container 12 of the sample rack 10 transported to the dispensing position (dispensing area) on the dispensing line 209. Then, it descends and sucks a predetermined amount of the sample held in the sample container 12.
  • the sample dispensing mechanism 208 that has sucked the sample moves above the reaction disk 211 and then descends to discharge the sample into one of the reaction containers provided in the reaction disk 211. After the sample is dispensed into the reaction container, the reaction disk 211 rotates and moves to the reagent dispensing position.
  • the reagent dispensing mechanism 219 can rotate and move up and down, and after moving to the upper side of the reagent container in the temperature-controlled reagent disk 218, descends to suck a predetermined amount of the reagent in the reagent container.
  • the reagent dispensing mechanism 219 moves above the reaction disk 211 and then descends to discharge the reagent into the reaction container in which the sample was dispensed previously.
  • the reaction disk 211 from which the reagent has been discharged, rotates and moves to the stirring position, and the stirring mechanism (not shown) stirs the sample and the reagent.
  • the reaction disk 211 rotates, moves to the measurement position, and the measurement unit 217 measures the optical characteristics of the mixed liquid in the reaction container.
  • the control unit 201 is a computer that controls the operation required for the analysis processing in the analysis module 200, and controls the operation of each device in the analysis module 200 based on a command from the control device 400 described later.
  • the analysis module 300 measures the dispensing line 309, the sample identifying device 310, the sample dispensing mechanism 308, the incubator disc 311, and the mixed liquid (reaction liquid) of the sample and the reagent dispensed in the reaction container to perform qualitative and quantitative determination.
  • Measuring unit 323 for performing analysis, reagent dispensing mechanism 319, reagent disc 318, sample dispensing chip and reaction container transporting mechanism 326, reaction liquid suction nozzle 327, transfer mechanism 332, magnetic separation unit 334, sample dispensing chip and reaction container A holding member 328, a reaction container stirring mechanism 329, a sample dispensing tip and a reaction container discarding hole 330, and a control unit 301 are provided.
  • the structures of the dispensing line 309, the sample identifying device 310, the sample dispensing mechanism 308, the reagent disc 318, and the reagent dispensing mechanism 319 are respectively the dispensing line 209, the sample identifying device 210, and the sample dispensing mechanism 208 of the analysis module 200. , Reagent disk 218 and reagent dispensing mechanism 219.
  • the incubator disk 311 can be provided with a plurality of reaction vessels for holding a reaction solution obtained by mixing and reacting a sample and a reagent, and rotation for moving the reaction vessels installed in the circumferential direction to respective predetermined positions. Exercise is possible. Unlike the reaction container of the analysis module 200, the reaction container on the incubator disk 311 side is disposable.
  • the sample dispensing tip/reaction container transport mechanism 326 is movable in three directions of the X-axis, Y-axis, and Z-axis, and the sample dispensing chip/reaction container holding member 328, reaction container stirring mechanism 329, sample dispensing chip Further, the reaction container discarding hole 330, the sample dispensing tip mounting position 331, and the incubator disk 311 are moved within a predetermined range to carry the sample dispensing tip and the reaction container.
  • a plurality of unused reaction containers and sample dispensing tips are installed on the sample dispensing tip and reaction container holding member 328.
  • the sample dispensing tip and reaction container transport mechanism 326 moves and descends above the sample dispensing chip and reaction container holding member 328 to grip an unused reaction container and then rises, and further above a predetermined position of the incubator disc 311. And move down to install the reaction vessel.
  • a plurality of reagent containers are installed on the reagent disk 318.
  • a reagent disk cover is provided above the reagent disk 318, and the inside of the reagent disk 318 is kept at a predetermined temperature.
  • a reagent disc cover opening is provided in a part of the reagent disc cover.
  • the reagent dispensing mechanism 319 is rotatable and vertically movable.
  • the reagent dispensing mechanism 319 is rotated and moved above the opening of the reagent disc cover, and then lowered, so that the tip of the reagent dispensing mechanism 319 is dipped in a reagent in a predetermined reagent container. , Aspirate a predetermined amount of reagent.
  • the reagent dispensing mechanism 319 moves up and then rotationally moves above a predetermined position of the incubator disc 311 to discharge the reagent into the reaction container.
  • the sample dispensing tip and reaction container transporting mechanism 326 moves to above the sample dispensing chip and reaction container holding member 328, descends to grip an unused sample dispensing chip, and then rises to move the sample dispensing chip. It moves above the mounting position 331 and descends to install the sample dispensing tip.
  • the sample dispensing mechanism 308 can rotate and move up and down, and is rotated above the sample dispensing tip mounting position 331, then lowered, and press-fitted to mount the sample dispensing tip on the tip. ..
  • the sample dispensing mechanism 308, to which the sample dispensing tip is mounted moves above the sample container 12 placed on the sample rack 10 and then descends, and is held by the sample container 12 transported by the dispensing line 309. A predetermined amount of the sample is aspirated.
  • the sample dispensing mechanism 308 that has sucked the sample moves above the incubator disk 311 and then descends to discharge the sample into the reaction container in which the reagent has been discharged previously.
  • the sample dispensing mechanism 308 moves above the sample dispensing tip and the reaction container discarding hole 330, and the used sample dispensing tip is discarded.
  • the reaction container from which the sample and the reagent are discharged is moved to a predetermined position by the rotation of the incubator disk 311, and is transported to the reaction container stirring mechanism 329 by the sample dispensing tip and the reaction container holding member 328.
  • the reaction container stirring mechanism 329 stirs and mixes the sample and the reagent in the reaction container by applying rotational motion to the reaction container.
  • the reaction container after stirring is returned to a predetermined position of the incubator disk 311 by the sample dispensing tip and the reaction container holding member 328.
  • the transfer mechanism 332 transfers the reaction container placed on the incubator disk 311 to the magnetic separation unit 334 for a predetermined time, and the sample is magnetically separated. After the magnetic separation process is completed, the transfer mechanism 332 transfers the reaction container to the incubator disk 311 again.
  • the reaction container which has been placed on the incubator disk 311, for a predetermined time, is conveyed to directly below the reaction solution suction nozzle 327 by the transfer mechanism 332, and the reaction solution is measured by the reaction solution suction nozzle 327. It is guided to the section 323.
  • a signal from the reaction solution is detected by the measuring unit 323 and output to the control device 400.
  • the reaction container in which the reaction liquid has been sucked is returned to the incubator disc 311 by the transfer mechanism 332. Thereafter, the incubator disc 311 is rotated to move to a predetermined position, and is moved from the incubator disc 311 to above the sample dispensing tip and reaction container discarding hole 330 by the sample dispensing tip and reaction container holding member 328 and is discarded.
  • the control unit 301 is a computer that controls the operation required for the analysis processing in the analysis module 300, and controls the operation of each device in the analysis module 300 based on a command from the control device 400 described later.
  • the apparatus layout of the devices in the modules of the analysis modules 200 and 300 arranged so as to sandwich the sample rack distribution module 100, that is, the arrangement relationship between the devices is a straight line 100A passing through the rotation center of the standby disk 106. It is line symmetric with respect to.
  • the devices included in the device layout include dispensing lines 209 and 309, sample dispensing mechanisms 208 and 308, a reaction disk 211 holding a reaction container for mixing a sample and a reagent, an incubator disk 311, and a sample analysis.
  • One or more out of the consumables installation section for installing the consumables used in.
  • the dispensing lines 209 and 309 are arranged on the sample rack distribution module 100 side on the upper side in FIG. 1 in each of the analysis modules 200 and 300.
  • the sample dispensing mechanisms 208 and 308 are arranged around the respective dispensing lines 209 and 309.
  • the reaction disk 211 or the incubator disk 311 for reacting the sample with the reagent is arranged on the lower side in FIG. 1 with respect to the sample dispensing mechanisms 208 and 308.
  • the measuring units 217 and 323 are arranged around the reaction disk 211 or the incubator disk 311 in the respective analysis modules 200 and 300, and are arranged at positions easily accessible.
  • a measurement unit for measuring the electrolyte item may be further mounted on the analysis module 200 side, and this measurement unit also surrounds the reaction disk 211, particularly dispensed. It is preferably arranged between the line 209 and the reaction disk 211.
  • the reagent disks 218 and 318 are located farthest from the sample rack distribution module 100 in the respective analysis modules 200 and 300, and the other mechanism is not arranged below them in FIG. It is arranged for easy access. Note that these reagent disks 218 and 318 are devices that the user frequently accesses to replace reagents used for analysis, so-called reagent containers that store assay reagents individually prepared for each measurement target item, and the like. Included in the consumables installation section.
  • reagent bottle installation unit (not shown) for installing a bottle is included.
  • the reagent bottle installation unit is a mechanism often provided on the lower side surface of the analysis modules 200 and 300 in FIG. 1.
  • the analysis modules 200 and 300 are respectively provided with covers 200A and 300A that open in the same direction as shown in FIG. 4 so that the operability is improved, and the user can access each device from the same direction. it can.
  • FIG. 4 is a view when the analysis module 300 is viewed from the direction A-A′ in FIG. 1 and when the cover 200A is viewed when the analysis module 200 is viewed from the direction B-B′.
  • control device 400 controls the overall operation of the automatic analysis system 1, and includes a display unit 403, an input unit 404, a storage unit 402, and a control unit 401.
  • the display unit 403 is a display device such as a liquid crystal display that displays input screens for various parameters and settings required for analysis, analysis inspection data for initial inspection or reinspection, information related to the progress of analysis, measurement results, and the like. is there.
  • the input unit 404 is a device for inputting various parameters and settings, analysis request information, instructions for starting analysis, etc., and is composed of a keyboard and a mouse.
  • the storage unit 402 is a device that stores various parameters and settings, measurement results, analysis request information of the sample contained in the sample container 12 mounted on each sample rack, and a semiconductor memory such as a flash memory or an HDD. It is composed of a magnetic disk and the like.
  • the storage unit 402 also records various computer programs and the like for controlling the operation of each device in the automatic analysis system 1 and executing various display processes described later.
  • the control unit 401 is a computer including a CPU, a memory, and the like, controls various operations of the above-described members, and determines the concentration of a predetermined component in the sample from the detection results performed by the measurement units 217 and 323. Perform the required arithmetic processing.
  • the control of the operation of each device by the control unit 401 is executed based on various programs recorded in the storage unit 402.
  • control processing of the operation executed by the control unit 401 may be integrated into one program, each may be divided into a plurality of programs, or a combination thereof. Further, part or all of the program may be realized by dedicated hardware or may be modularized.
  • 5 and 6 are views showing an example of the arrangement of the sample rack distribution module and the analysis module in the conventional automatic analysis system for comparison.
  • FIG. 7 is a diagram showing an arrangement example of the sample rack distribution module and the analysis module in the automatic analysis system according to the first embodiment
  • FIG. 8 is a sample rack distribution module and the analysis module in the automatic analysis system according to the first embodiment. It is a figure which shows another example of arrangement
  • FIG. 9 is a matrix for explaining the effect of shortening the transportation time in the automatic analysis system according to the first embodiment.
  • the standby disk 106 is counterclockwise from the connection between the standby disk 106 of the sample rack distribution module 100 and the transfer line 104 to the connection between the standby disk 106 and the dispensing line 209 of the analysis module 200.
  • the angle when rotated around is ⁇ 1.
  • the angle when the standby disk 106 is rotated clockwise from the connection portion between the standby disk 106 and the transport line 104 to the connection portion between the standby disk 106 and the dispensing line 209 of the analysis module 300 is defined as ⁇ 2.
  • the arrangement configuration of the transfer line and the dispensing line is set in the four cases shown in FIGS. 5 to 8 described later from the viewpoint of the required movement angle until the rack is supplied to the analysis module with respect to the values of ⁇ 1 and ⁇ 2. Can be divided.
  • the rack transport route until the sample is supplied to the analysis module is divided into two ways.
  • One is a transport path for measuring the sample only by the analysis module 200
  • the other is a route for transporting the sample to the analysis module 300 after measuring the sample by the analysis module 200 and measuring the sample.
  • the analysis module 200 has a higher analysis request and a higher transportation frequency than the analysis module 300.
  • the route for measuring the sample only by the analysis module 300 and the route for measuring the sample by the analysis module 300 and then transporting the sample to the analysis module 200 to measure the sample are the route only for the analysis module 200 and the analysis module 200, respectively. ⁇ Since the route and the way of thinking of the analysis module 300 are substantially the same, the study is omitted.
  • FIG. 5 in which the transfer line and the dispensing line of one analysis module are arranged on a parallel line
  • FIG. 6 in which the dispensing lines of two analysis modules are arranged on a parallel line are one transfer line as a comparative example
  • FIG. 7 and FIG. 8 in which neither the transfer line nor the dispensing line of the two analysis modules are arranged on parallel lines are examples of the arrangement of this embodiment.
  • the actual movement angle of the sample rack 10 or the like on the standby disk 106 actually includes the rotation movement angle for loading/unloading another sample rack 10 or the like in addition to the required movement angle. Only the necessary movement angle that does not consider the rotational movement angle of the other sample racks 10 will be described.
  • the angle ⁇ 1 formed by the transport line 104 and the dispensing line 209 is 90.
  • the angle ⁇ 2 formed by the transport line 104 and the dispensing line 309 is greater than 90° and less than 180°.
  • the angle between the adjacent rack filling points is 180°/n.
  • the required movement angle is ⁇ 1 and is 90° as shown by the arrow (A) in FIG. 7.
  • the necessary movement angle excluding the rotation of the standby disk 106 in standby is indicated by an arrow (B) in FIG. 7. As shown, it is 360° ⁇ 2.
  • the required movement angle is 360° ⁇ 2 in both FIG. 5 and FIG. 7.
  • the required movement angle is always smaller than 270°.
  • the arrangement configuration in FIG. 7 is superior to the arrangement configurations in FIGS. 5 and 6 in terms of the required movement angle. That is, it is understood that the transport time of the sample rack 10 can be shortened by not arranging the transport line 104 and the dispensing lines 209 and 309 in parallel with each other.
  • the angle ⁇ 1 formed by the transport line 104 and the dispensing line 209A is 90°.
  • the angle ⁇ 2 formed by the transport line 104 and the dispensing line 309A is less than 90°. Also in this case, assuming that the number of sample rack filling points on the standby disk 106 is 2n (n is a natural number), the angle between the adjacent rack filling points is 180°/n.
  • the required movement angle 2 ⁇ 1+ ⁇ 2 in FIG. 8 is 90° or less or less than 90° in FIG. 8 as compared with the required movement angle 360° ⁇ 2 in FIG. 2 ⁇ 1+ ⁇ 2 never exceeds 270°.
  • ⁇ 2 is less than 90°, 360° ⁇ 2 does not become 270° or less. Therefore, the required movement angle in FIG. 8 is always smaller than that in FIG.
  • the arrangement configuration of FIG. 8 is also an advantageous arrangement configuration from the viewpoint of the required moving angle, compared to either of FIG. 5 and FIG.
  • Table 1 is a table showing the configuration of the arrangement of FIGS. 5 to 9 and the transportation conditions, and the required movement angle required under each condition.
  • FIG. 9 is a matrix for explaining the effect of shortening the transportation time by the sample rack transportation method according to the present embodiment.
  • the horizontal axis represents ⁇ 1 and the vertical axis represents ⁇ 2, and the required movement angle of the transport path (B) with respect to the values of ⁇ 1 and ⁇ 2 is shown.
  • the required movement angle of the transport path (B) is the same in FIGS. It can be seen that the transport time can be shortened because the size is smaller.
  • the above-described automatic analysis system 1 conveys a plurality of analysis modules 200 and 300 that mix and analyze a sample with a reagent, a sample rack 10 that holds a sample container 12 containing a sample, and the like.
  • a sample rack distribution module 100 that has a transport line 104 and a rotatable standby disk 106 in which a plurality of slots 106A that can hold the sample rack 10 and the like are formed, and that supplies the sample rack 10 and the like to the analysis modules 200 and 300.
  • the analysis modules 200 and 300 respectively include the sample dispensing mechanisms 208 and 308 for dispensing the samples held in the sample rack 10 and the sample dispensing mechanisms 208 and 308 from the sample rack distribution module 100.
  • Dispensing lines 209 and 309 for retracting and delivering the sample rack 10 to the pouring position are provided, and the transport line 104 and the plurality of dispensing lines 209 and 309 are arranged so as not to be parallel to each other.
  • the apparatus layout of the analysis modules 200 and 300 arranged with the sample rack distribution module 100 sandwiched is line-symmetric with respect to the straight line 100A passing through the rotation center of the standby disk 106.
  • the transport amount of the sample rack 10 can be reduced by the device layout configuration. Since it is possible to reduce the time waiting for the transportation of the sample, it is possible to prevent the apparatus from increasing in size and to reduce the transport distance of the sample rack 10 and the emergency sample rack 11 as compared with the configuration of the conventional technique. Therefore, the transport time of the entire sample rack 10 can be shortened, and the efficiency of the sample supply speed in the processing capacity of the automatic analysis system can be improved. As a result, it is possible to shorten the TAT (Turn Around Time) required from outputting the sample to outputting the measurement result as compared with the conventional system. In addition, the accessibility of the user can be improved as compared with the conventional device configuration.
  • TAT Transmission Around Time
  • dispensing lines 209 and 309 are arranged so that the lines of the plurality of dispensing lines 209 and 309 extending in the transport direction of the sample rack 10 and the like pass through the slot 106A of the standby disk 106, respectively, will be described later.
  • the device configuration can be simplified as compared with the configuration of the second embodiment.
  • the sample rack 10 and the like are pulled in from the standby disk 106 and transferred, by further including the transporting convex portions 120, 220, and 320 that fit into the concave portions 13 provided on the bottom surface of the sample rack 10 and the like, It is possible to employ a mechanism such as a transport belt that does not require consideration of wear and that can easily transport the sample rack 10 and the like, and thus it is possible to more reliably prevent an increase in size of the apparatus.
  • the dispensing line 209 is accessed as compared to the dispensing line 309.
  • the angle formed by the transfer line 104 and the dispensing line 209 is 90° or less and the angle formed by the transfer line 104 and the dispensing line 309 is greater than 90° and less than 180°.
  • the required movement angle to the side of the dispensing line 209 that is frequently accessed can be reduced, and the time required for transportation can be more reliably shortened.
  • the required movement angle is minimized by satisfying the relationship that the angle between the transfer line 104 and the dispensing line 209 is 90° or less and the angle between the transfer line 104 and the dispensing line 309 is less than 90°.
  • the configuration can be adopted, and the arrangement is particularly suitable when high processing capacity is required.
  • the dispensing lines 209 and 309 are connected in a direction that extends radially from the center of the standby disk 106, the slot 106A for holding the sample rack 10 and the like can be efficiently formed in the standby disk 106, The standby disk 106 can be downsized.
  • the devices included in the apparatus layout are used for the dispensing lines 209 and 309, the sample dispensing mechanisms 208 and 308, the reaction disk 211 that holds the reaction container for mixing the sample and the reagent, the incubator disk 311, and the sample analysis.
  • the consumables installation section for installing the consumables it is possible to arrange, on the same side in the system, devices that are greatly related to the transportation of the sample rack 10 and devices that are frequently accessed by the user. , Can greatly contribute to improving user access.
  • sample dispensing mechanisms 208, 308 are arranged between the respective dispensing lines 209, 309 and the reaction disk 211, the incubator disk 311, so that the moving distance of the sample dispensing mechanisms 208, 308 can be reduced. Therefore, the analysis cycle can be reliably shortened, and TAT can be more reliably shortened.
  • the consumables installation section includes the reagent disks 218 and 318 that hold the reagent containers that contain the reagents, so that the reagent disks 218 and 318 that the user frequently accesses for loading and unloading the assay reagents.
  • the device layout can be the same in the analysis modules 200 and 300, and the user access can be surely improved.
  • Example 2 An automatic analysis system and a sample transportation method according to Example 2 of the present invention will be described with reference to FIGS. 10 to 19.
  • the same components as those in the first embodiment are designated by the same reference numerals and the description thereof will be omitted. The same applies to the following examples.
  • the other dispensing line 209B and 309B is connected to the slot 106A of the standby disk 106. It is arranged so as to be connected to the area 106B which is not connected to the sample rack 10 and does not hold the sample rack 10.
  • the line of the dispensing line 309B extending in the transport direction does not pass through the slot 106A of the standby disk 106 and is adjacent to the slot 106A.
  • the dispensing line 309B is arranged so as to pass through the region 106B between the slot 106A and the slot 106A.
  • FIG. 10 and FIG. 11 are views showing an example in which the transport angles of the sample racks from the sample rack distribution module 100 to the two left and right dispensing lines 209B and 309B are shifted by a predetermined angle according to the second embodiment. is there.
  • a slot 106A in which the transporting projection 220 can reciprocate and a slot 106A at which the sample rack 10 can be housed are provided in the standby disk 106. It has a region 106B that is present in the middle and is in a position where the sample rack 10 cannot be accommodated and in which the transporting protrusion 220 can reciprocate.
  • FIG. 12 is a top view showing the structure of the standby disk 106 and the moving path 222 of the transporting protrusions 120, 220, 320.
  • the transporting protrusions 120, 220, 320 reciprocate in each of the regions 106B in addition to the slot 106A portion of the standby disk 106.
  • a movement path 224 is provided so that the movement can be performed.
  • 13 to 15 are diagrams for explaining the operation of the transporting convex portions 120, 220, 320 according to the present embodiment and the operation of the standby disk of the sample rack distribution module.
  • the transporting convex portion 220 moves on the dispensing line 209B toward the standby disk 106 with the sample rack 10 placed thereon, and moves to the predetermined position on the standby disk 106 at the predetermined position. Hand over.
  • the sample rack 10 can be transferred between the standby disk 106 and the dispensing line 209B, and preparation for transfer can be performed. Similarly, the sample rack 10 can be transferred to and from the dispensing line 309B of the other analysis module 300 and the transport line 104, and preparation for transfer can be performed.
  • 16 to 19 are time charts for explaining the effect of shortening the transport time by transporting the sample rack with the configuration according to the present embodiment.
  • the cycle time from when the sample rack 10 is received by the dispensing lines 209B and 309B of the analysis modules 200 and 300 to when it is returned to the standby disk 106 may be different due to the difference in the measurement principle. is there.
  • the horizontal axis represents time (sec)
  • the vertical axis represents four operating units (conveying line 104, standby disk 106, left and right dispensing lines 209B, 309B).
  • Each of the blocks includes a linear movement of the conveyance convex portion 120 of the conveyance line 104, a rotation movement of the standby disk 106, a linear movement of the conveyance convex portion 220 of the dispensing lines 209, 209A and 209B, and a dispensing line 309, 309A.
  • 309B shows the linear movement of the transporting protrusion 320.
  • the emergency sample rack 11 does not intervene, and the sample rack 10 is continuously exchanged between the left and right dispensing lines 209, 209A, 209B, 309, 309A, 309B and the standby disk 106.
  • the case (after the right) will be described.
  • the right side dispensing line 209B moves to the standby disk 106 of the sample rack 10. And the sample rack 10 to be dispensed next is transported (received).
  • the same transport is performed also on the left dispensing line 309B, and then the sample racks 10 collected from the respective dispensing lines 209B and 309B are sent from the standby disk 106 to the transport line 104, and the next unmeasured sample enters.
  • the sample rack 10 is transferred from the transport line 104 to the standby disk 106.
  • the rotation operation of the standby disk 106 occurs during each sample rack transport operation.
  • the sample rack 10 is received by one of the dispensing lines 209B and 309B also in the second embodiment.
  • the operation that only the transporting convex portion 320 moves alone does not occur.
  • the transport line 104 transfers the sample rack 10 to the sample rack unloading unit 103.
  • the time required for one cycle which is a unit of a cycle until being sent and collected, is the same.
  • the configuration of the second embodiment it is possible to move only the transporting convex portion 320 to the standby disk 106 at the same time by utilizing the time during which the sample rack 10 is acquired in the dispensing line 209B. Therefore, since the sample rack 10 can be moved from the dispensing line 309B into the standby disk 106 in the next operation cycle, the time required for one cycle described above can be shortened as compared with the first embodiment.
  • the time required for the operation can be shortened.
  • the transporting protrusion 320 is simultaneously moved from the left dispensing line 309B to the standby disc. It can be moved into 106. Therefore, the time required for one cycle can be shortened, and by repeating this cycle, the overall transport time can be shortened.
  • the analysis module with the shorter analysis cycle is the main, and the analysis module with the slower analysis cycle is the sub.
  • cycle times are as seconds and at seconds (a, s, t are natural numbers, s). If t and t are prime to each other and s ⁇ t), in the configuration of the first embodiment, the operation of simultaneously receiving or delivering the sample rack 10 is possible only at the timing of the least common multiple of s and t.
  • the timing of the least common multiple is 60 seconds. That is, in the configuration of the first embodiment in which the transporting convex portions 220 and 320 are connected only to the slot 106A corresponding to the position where the sample rack 10 can be stored, the transfer of the sample rack 10 is performed simultaneously for 60 seconds. Once every time.
  • the sample rack 10 is transferred and received on one of the dispensing lines 209B 14 times for 60 seconds, and then the other sample rack 10 is received to receive the sample rack 10.
  • the injection line 309B there is a timing at which the carrying preparation operation for housing only the carrying convex portion 320 in the standby disk 106 is simultaneously executed.
  • the simultaneous transport operation occurs every ast seconds, whereas the transport+preparation operation occurs t-1 times in total every as seconds until the ast seconds.
  • the transport+preparation operation occurs 0 times in total.
  • At least one or more of the plurality of dispensing lines 209 and 309 extending in the transport direction of the sample rack 10 or the like does not pass through the slot 106A of the standby disk 106, and is between the slot 106A and the adjacent slot 106A. Since the dispensing lines 209 and 309 are arranged so as to pass through, the dispensing line 209B of the analysis module 200 exchanges the sample rack 10 with the transporting protrusion 120 in the slot 106A of the standby disk 106, for example. While the analysis module 300 is operating, the transporting protrusion 220 can be sent to the area 106B of the standby disk 106 from the dispensing line 309B of the analysis module 300. Therefore, the sample rack 10 can be moved to the dispensing lines 209B and 309B at an earlier timing compared with the configuration of the first embodiment.
  • Sample dispensing mechanism 209, 209A, 209B Dispensing line (first dispensing line) 210, 310... Specimen identification device 211... Reaction disk 217, 323... Measuring section 218, 318... Reagent disk 219, 319... Reagent dispensing mechanism 220A... Rail 220B... Motor 222, 224... Movement path 309, 309A, 309B... Minute Note line (second dispensing line) 311... Incubator disk 326... Reaction container transport mechanism 327... Reaction liquid suction nozzle 328... Reaction container holding member 329... Reaction container stirring mechanism 330... Reaction container discarding hole 331... Specimen dispensing tip mounting position 332... Transfer mechanism 334... Magnetic separation Part 400... Control device 401... Control part 402... Storage part 403... Display part 404... Input part 1104... Conveying line 1106... Standby disk 1209A, 1209B, 1309A, 1309B... Dispensing line

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un système d'analyse automatique dans lequel une ligne de transport (104) et une pluralité de lignes de distribution (209, 309) sont disposées de façon à ne pas être parallèles, et une disposition de dispositif de modules d'analyse (200, 300) disposés avec un module de distribution de porte-échantillons (100) entre ces derniers est symétrique en ligne par rapport à une ligne droite (100A) passant par le centre de rotation d'un disque de secours (106). Ainsi, même lorsque le système d'analyse automatique présente une configuration permettant de fournir des échantillons depuis un module de distribution de porte-échantillons commun à une pluralité de modules d'analyse, l'efficacité de transport d'un porte-échantillons est augmentée et l'accessibilité de l'utilisateur est bonne.
PCT/JP2019/047051 2019-01-25 2019-12-02 Système d'analyse automatique et procédé de transport d'échantillon WO2020152991A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2020567395A JP7053898B2 (ja) 2019-01-25 2019-12-02 自動分析システムおよび検体の搬送方法
CN201980078369.5A CN113874730A (zh) 2019-01-25 2019-12-02 自动分析系统及样本的传送方法
EP19910927.3A EP3916396B1 (fr) 2019-01-25 2019-12-02 Système d'analyse automatique et procédé de transport d'échantillon
US17/294,190 US20220011333A1 (en) 2019-01-25 2019-12-02 Automatic Analysis System and Specimen Conveying Method

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JP2019011439 2019-01-25
JP2019-011439 2019-01-25

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WO2022179350A1 (fr) * 2021-02-24 2022-09-01 深圳市亚辉龙生物科技股份有限公司 Système d'inspection et d'analyse communes d'échantillon

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EP1099950A1 (fr) * 1999-11-12 2001-05-16 F. Hoffmann-La Roche Ag Appareil d'analyse avec un support rotatif de présentoir d'échantillon
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JPH10339732A (ja) * 1997-04-10 1998-12-22 Hitachi Ltd 自動分析装置およびその支援システム
JP2000105246A (ja) * 1998-09-29 2000-04-11 Hitachi Ltd 自動分析装置
JP2003262642A (ja) * 2002-03-07 2003-09-19 Hitachi High-Technologies Corp 自動分析装置
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JP2009216459A (ja) * 2008-03-07 2009-09-24 Sysmex Corp 分析装置および測定ユニット
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WO2022179350A1 (fr) * 2021-02-24 2022-09-01 深圳市亚辉龙生物科技股份有限公司 Système d'inspection et d'analyse communes d'échantillon

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EP3916396A1 (fr) 2021-12-01
US20220011333A1 (en) 2022-01-13
JPWO2020152991A1 (ja) 2021-10-21
EP3916396A4 (fr) 2022-10-19
CN113874730A (zh) 2021-12-31
EP3916396B1 (fr) 2024-03-27
JP7053898B2 (ja) 2022-04-13

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