WO2020151261A1 - Structure de fibre semblable à la fibre de coton, son procédé de préparation et son application - Google Patents

Structure de fibre semblable à la fibre de coton, son procédé de préparation et son application Download PDF

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Publication number
WO2020151261A1
WO2020151261A1 PCT/CN2019/110974 CN2019110974W WO2020151261A1 WO 2020151261 A1 WO2020151261 A1 WO 2020151261A1 CN 2019110974 W CN2019110974 W CN 2019110974W WO 2020151261 A1 WO2020151261 A1 WO 2020151261A1
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WO
WIPO (PCT)
Prior art keywords
cotton
fiber
fiber scaffold
bioglass
spinning
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PCT/CN2019/110974
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English (en)
Chinese (zh)
Inventor
李子樵
周杰
徐嘉麟
Original Assignee
蓝怡科技集团股份有限公司
浙江蓝怡医药有限公司
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Application filed by 蓝怡科技集团股份有限公司, 浙江蓝怡医药有限公司 filed Critical 蓝怡科技集团股份有限公司
Publication of WO2020151261A1 publication Critical patent/WO2020151261A1/fr

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    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
    • D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
    • D01D5/0092—Electro-spinning characterised by the electro-spinning apparatus characterised by the electrical field, e.g. combined with a magnetic fields, using biased or alternating fields
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/88—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds
    • D01F6/92—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds of polyesters
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
    • D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
    • D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
    • D04H1/76—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres otherwise than in a plane, e.g. in a tubular way
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

Abstract

La présente invention concerne une structure de fibre semblable à la fibre de coton ainsi que son procédé de préparation et son application. L'invention concerne également une structure de fibre semblable à la fibre de coton présentant un taux de compression aussi élevé que 45 %, un taux de récupération aussi élevé que 80 % et une adaptabilité assez élevée qui peut être préparée en utilisant un procédé de filage électrostatique pour mélanger et filer l'acide polylactique et des matériaux bioactifs tels que le bioverre, le phosphate bêta-tricalcique ou le sulfate de calcium. La structure préparée de fibre semblable à la fibre de coton a un diamètre de fibre plus petit, une plus grande flexibilité, une porosité plus élevée et une surface spécifique, et peut fournir davantage de points de fixation d'ostéoblastes et raccourcir le temps de rééducation. La structure présente en outre une excellente activité biologique, une excellente biocompatibilité et une excellente biodégradabilité. Une partie inorganique de la structure peut être dégradée in vivo pour générer des éléments essentiels à l'ostéogenèse. L'acide polylactique d'une partie inorganique présente une bonne biodégradabilité et une bonne biocompatibilité et peut être dégradé pour générer de l'acide lactique. L'acide lactique est ensuite converti en dioxyde de carbone et en eau sous l'action d'une enzyme. La structure de fibre semblable à la fibre de coton n'a pas d'effets secondaires toxiques sur le corps humain.
PCT/CN2019/110974 2019-01-25 2019-10-14 Structure de fibre semblable à la fibre de coton, son procédé de préparation et son application WO2020151261A1 (fr)

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Application Number Priority Date Filing Date Title
CN201910073477.5A CN109594195B (zh) 2019-01-25 2019-01-25 一种棉花状纤维支架及其制备方法和用途
CN201910073477.5 2019-01-25

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WO2020151261A1 true WO2020151261A1 (fr) 2020-07-30

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WO (1) WO2020151261A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112144176A (zh) * 2020-09-01 2020-12-29 郑州大学 一种通过酶促降解pcl/plla聚合物生产多孔三维材料的方法
CN114575037A (zh) * 2022-03-09 2022-06-03 诺一迈尔(苏州)生命科技有限公司 一种静电纺纳米纤维膜及其制备方法
CN115748239A (zh) * 2022-12-08 2023-03-07 山东大学 一种高强度和柔性羟基磷灰石包覆的二氧化硅复合纤维膜的制备方法
CN115748239B (zh) * 2022-12-08 2024-05-14 山东大学 一种高强度和柔性羟基磷灰石包覆的二氧化硅复合纤维膜的制备方法

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CN109594195B (zh) * 2019-01-25 2021-11-05 蓝怡科技集团股份有限公司 一种棉花状纤维支架及其制备方法和用途

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CN101172164A (zh) * 2006-11-03 2008-05-07 中国科学院化学研究所 可生物降解及吸收的生物高分子纳米纤维膜材料及其制法和用途
CN101387015A (zh) * 2008-10-24 2009-03-18 暨南大学 一种聚乳酸纳米纤维的制备方法
GB2484319A (en) * 2010-10-06 2012-04-11 Univ Bolton Electrospinning fibres comprising honey and biocompatible polymer
CN102499997A (zh) * 2011-12-27 2012-06-20 吉林大学 复合纳米纤维支架材料、制备方法及在骨修复方面的应用
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CN105126175A (zh) * 2015-09-10 2015-12-09 南方医科大学南方医院 一种静电纺丝纤维可载药牙周组织再生材料及其制备方法
CN108289975A (zh) * 2016-04-28 2018-07-17 国立大学法人名古屋工业大学 用静电纺丝法制造含可生物降解纤维的骨再生材料的方法
CN109594195A (zh) * 2019-01-25 2019-04-09 蓝怡科技集团股份有限公司 一种棉花状纤维支架及其制备方法和用途

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112144176A (zh) * 2020-09-01 2020-12-29 郑州大学 一种通过酶促降解pcl/plla聚合物生产多孔三维材料的方法
CN114575037A (zh) * 2022-03-09 2022-06-03 诺一迈尔(苏州)生命科技有限公司 一种静电纺纳米纤维膜及其制备方法
CN115748239A (zh) * 2022-12-08 2023-03-07 山东大学 一种高强度和柔性羟基磷灰石包覆的二氧化硅复合纤维膜的制备方法
CN115748239B (zh) * 2022-12-08 2024-05-14 山东大学 一种高强度和柔性羟基磷灰石包覆的二氧化硅复合纤维膜的制备方法

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CN109594195B (zh) 2021-11-05

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